KBTBD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.55700753
2cilium or flagellum-dependent cell motility (GO:0001539)6.31843660
3male meiosis (GO:0007140)6.20333571
4DNA methylation involved in gamete generation (GO:0043046)5.49531545
5synaptonemal complex organization (GO:0070193)5.30009979
6pyrimidine nucleobase catabolic process (GO:0006208)5.24020607
7synaptonemal complex assembly (GO:0007130)5.19565865
8meiotic cell cycle (GO:0051321)4.99052928
9fusion of sperm to egg plasma membrane (GO:0007342)4.97786355
10meiotic chromosome segregation (GO:0045132)4.94293723
11protein localization to chromosome, centromeric region (GO:0071459)4.87674394
12mitotic sister chromatid segregation (GO:0000070)4.85870192
13presynaptic membrane assembly (GO:0097105)4.85776203
14sperm-egg recognition (GO:0035036)4.65226384
15mitotic metaphase plate congression (GO:0007080)4.64829809
16histone exchange (GO:0043486)4.64382452
17multicellular organism reproduction (GO:0032504)4.62037229
18motile cilium assembly (GO:0044458)4.60124724
19binding of sperm to zona pellucida (GO:0007339)4.58984662
20protein K6-linked ubiquitination (GO:0085020)4.54933400
21protein localization to kinetochore (GO:0034501)4.54486444
22meiotic nuclear division (GO:0007126)4.52105595
23neuronal action potential propagation (GO:0019227)4.51935185
24chromosome organization involved in meiosis (GO:0070192)4.49704849
25nuclear pore complex assembly (GO:0051292)4.47467940
26kinetochore organization (GO:0051383)4.45559573
27axonemal dynein complex assembly (GO:0070286)4.45111549
28sister chromatid segregation (GO:0000819)4.41382374
29attachment of spindle microtubules to kinetochore (GO:0008608)4.36975555
30chromatin remodeling at centromere (GO:0031055)4.32321920
31microtubule depolymerization (GO:0007019)4.30449739
32CENP-A containing nucleosome assembly (GO:0034080)4.29255315
33mitotic chromosome condensation (GO:0007076)4.27801192
34nucleobase catabolic process (GO:0046113)4.25461638
35gene silencing by RNA (GO:0031047)4.24084768
36presynaptic membrane organization (GO:0097090)4.23114341
37metaphase plate congression (GO:0051310)4.22205473
38male meiosis I (GO:0007141)4.17471901
39cell-cell recognition (GO:0009988)4.16833589
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.12150946
41behavioral response to nicotine (GO:0035095)4.12147498
42sperm motility (GO:0030317)4.09655983
43spermatid development (GO:0007286)4.09516027
44neuron cell-cell adhesion (GO:0007158)4.09001669
45mitotic sister chromatid cohesion (GO:0007064)4.08468198
46nuclear pore organization (GO:0006999)4.05076733
47establishment of chromosome localization (GO:0051303)3.99573079
48DNA replication-independent nucleosome assembly (GO:0006336)3.99452469
49DNA replication-independent nucleosome organization (GO:0034724)3.99452469
50acrosome assembly (GO:0001675)3.97722143
51postsynaptic membrane organization (GO:0001941)3.94728152
52positive regulation of mitochondrial fission (GO:0090141)3.88498568
53gamma-aminobutyric acid transport (GO:0015812)3.86083491
54regulation of meiosis I (GO:0060631)3.85460787
55DNA replication-dependent nucleosome organization (GO:0034723)3.84774291
56DNA replication-dependent nucleosome assembly (GO:0006335)3.84774291
57DNA replication initiation (GO:0006270)3.80860104
58meiotic cell cycle process (GO:1903046)3.80808294
59translesion synthesis (GO:0019985)3.80057465
60mitotic nuclear envelope disassembly (GO:0007077)3.79669693
61kinetochore assembly (GO:0051382)3.74692111
62pore complex assembly (GO:0046931)3.74394487
63monoubiquitinated protein deubiquitination (GO:0035520)3.73897131
64meiosis I (GO:0007127)3.73682843
65acrosome reaction (GO:0007340)3.71330373
66epithelial cilium movement (GO:0003351)3.66768775
67plasma membrane fusion (GO:0045026)3.56165671
68chromosome segregation (GO:0007059)3.55128793
69vocalization behavior (GO:0071625)3.55009673
70reproduction (GO:0000003)3.51923736
71axonal fasciculation (GO:0007413)3.49570452
72chromosome condensation (GO:0030261)3.49472852
73regulation of spindle organization (GO:0090224)3.47965405
74membrane disassembly (GO:0030397)3.47535502
75nuclear envelope disassembly (GO:0051081)3.47535502
76regulation of centrosome cycle (GO:0046605)3.46971391
77DNA strand elongation involved in DNA replication (GO:0006271)3.46319107
78telomere maintenance via semi-conservative replication (GO:0032201)3.44700161
79regulation of centriole replication (GO:0046599)3.44088626
80synapse assembly (GO:0007416)3.43316627
81regulation of chromosome segregation (GO:0051983)3.42707885
82DNA packaging (GO:0006323)3.42673952
83neuron recognition (GO:0008038)3.41814303
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38406969
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38406969
86positive regulation of mitotic sister chromatid separation (GO:1901970)3.38406969
87establishment of mitochondrion localization (GO:0051654)3.37558312
88protein localization to synapse (GO:0035418)3.37033531
89protein-cofactor linkage (GO:0018065)3.35845744
90protein localization to chromosome (GO:0034502)3.35787119
91somite development (GO:0061053)3.35189890
92ATP-dependent chromatin remodeling (GO:0043044)3.32173191
93sister chromatid cohesion (GO:0007062)3.31798591
94DNA replication checkpoint (GO:0000076)3.31469939
95telomere maintenance via recombination (GO:0000722)3.30636897
96DNA synthesis involved in DNA repair (GO:0000731)3.29627755
97regulation of histone H3-K9 methylation (GO:0051570)3.27843570
98mitotic recombination (GO:0006312)3.27283464
99histone H2A monoubiquitination (GO:0035518)3.27131713
100DNA strand elongation (GO:0022616)3.27057096
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26985506
102chromatin assembly or disassembly (GO:0006333)3.26135344
103DNA alkylation (GO:0006305)3.21618896
104DNA methylation (GO:0006306)3.21618896
105DNA double-strand break processing (GO:0000729)3.18190759
106positive regulation of chromosome segregation (GO:0051984)3.16896980
107DNA unwinding involved in DNA replication (GO:0006268)3.10589923
108negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09089479
109spindle checkpoint (GO:0031577)3.08041128
110mismatch repair (GO:0006298)3.07962524
111limb bud formation (GO:0060174)3.07762825
112chromosome organization (GO:0051276)3.06280664
113gene silencing (GO:0016458)3.04548810
114fertilization (GO:0009566)3.04371694
115head development (GO:0060322)3.02732977
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02718303
117single fertilization (GO:0007338)3.02477012
118regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01971176
119spermatogenesis (GO:0007283)3.01907856
120male gamete generation (GO:0048232)3.01859661
121regulation of spindle checkpoint (GO:0090231)3.01052224
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00617469
123postreplication repair (GO:0006301)3.00486919
124response to pheromone (GO:0019236)2.96445747
125synaptic transmission, glutamatergic (GO:0035249)2.94594616
126retinal ganglion cell axon guidance (GO:0031290)2.91437376
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91225229
128dendritic spine morphogenesis (GO:0060997)2.90924435
129protein K11-linked deubiquitination (GO:0035871)2.89944894
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89511368
131ionotropic glutamate receptor signaling pathway (GO:0035235)2.89071105
132cullin deneddylation (GO:0010388)2.87326143
133positive regulation of oligodendrocyte differentiation (GO:0048714)2.87322495
134auditory behavior (GO:0031223)2.85275126
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83795083
136dendrite morphogenesis (GO:0048813)2.81816669
137central nervous system projection neuron axonogenesis (GO:0021952)2.80490837
138glycosphingolipid biosynthetic process (GO:0006688)2.75754320
139mechanosensory behavior (GO:0007638)2.75130415
140protein localization to cilium (GO:0061512)2.74713172
141glutamate receptor signaling pathway (GO:0007215)2.74141381
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73144145
143neurotransmitter secretion (GO:0007269)2.73026453
144behavioral response to ethanol (GO:0048149)2.72917828
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72102966
146positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71979153
147regulation of feeding behavior (GO:0060259)2.71734989
148neurotransmitter-gated ion channel clustering (GO:0072578)2.70710858
149synaptic vesicle exocytosis (GO:0016079)2.70348944
150protein polyglutamylation (GO:0018095)2.69616431
151startle response (GO:0001964)2.68924433
152negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68228780
153hippocampus development (GO:0021766)2.67180731
154protein deneddylation (GO:0000338)2.66708034
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65984605
156neuron-neuron synaptic transmission (GO:0007270)2.64935728
157nonmotile primary cilium assembly (GO:0035058)2.63557572
158membrane depolarization during action potential (GO:0086010)2.62999705
159neural tube formation (GO:0001841)2.59101366
160cerebral cortex radially oriented cell migration (GO:0021799)2.57989794
161synaptic vesicle maturation (GO:0016188)2.56687109
162transmission of nerve impulse (GO:0019226)2.55789539
163spinal cord development (GO:0021510)2.55684651
164regulation of action potential (GO:0098900)2.55020282
165regulation of mitochondrial fission (GO:0090140)2.54528719
166neuronal action potential (GO:0019228)2.53201284
167regulation of telomere maintenance (GO:0032204)2.52388776
168synapse organization (GO:0050808)2.52313535
169glutamate secretion (GO:0014047)2.51848650
170regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.51076923
171replication fork processing (GO:0031297)2.50757530
172C4-dicarboxylate transport (GO:0015740)2.50187509
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45066355
174glycerophospholipid catabolic process (GO:0046475)2.43366238
175regulation of synaptic vesicle exocytosis (GO:2000300)2.41911802
176cell migration in hindbrain (GO:0021535)2.41628828
177positive regulation of synapse assembly (GO:0051965)2.40184920
178neuromuscular synaptic transmission (GO:0007274)2.38919346
179sympathetic nervous system development (GO:0048485)2.38898084
180negative regulation of dendrite development (GO:2000171)2.38264906
181regulation of collateral sprouting (GO:0048670)2.36409039
182homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.34702976
183prostate gland growth (GO:0060736)2.34619598
184negative regulation of telomere maintenance (GO:0032205)2.34094852
185central nervous system neuron axonogenesis (GO:0021955)2.33564776
186mitochondrion transport along microtubule (GO:0047497)2.33059882
187establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33059882
188regulation of oligodendrocyte differentiation (GO:0048713)2.32463730
189olfactory bulb development (GO:0021772)2.30476703
190behavioral fear response (GO:0001662)2.30113841
191behavioral defense response (GO:0002209)2.30113841
192regulation of synaptic vesicle transport (GO:1902803)2.29979978
193negative regulation of oligodendrocyte differentiation (GO:0048715)2.27505799
194cell proliferation in forebrain (GO:0021846)2.27148790
195mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.26770235
196mitochondrial respiratory chain complex I assembly (GO:0032981)2.26770235
197NADH dehydrogenase complex assembly (GO:0010257)2.26770235
198regulation of neurotransmitter levels (GO:0001505)2.26599534
199adult behavior (GO:0030534)2.25228666
200proline transport (GO:0015824)2.24881323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.07377781
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.53884913
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34686868
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.25204622
5EZH2_22144423_ChIP-Seq_EOC_Human3.82653859
6GBX2_23144817_ChIP-Seq_PC3_Human3.65309094
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38795560
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.22420249
9ZNF274_21170338_ChIP-Seq_K562_Hela3.10766256
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.03355011
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93245332
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82346632
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61385140
14VDR_22108803_ChIP-Seq_LS180_Human2.43250416
15IGF1R_20145208_ChIP-Seq_DFB_Human2.41067501
16AR_21909140_ChIP-Seq_LNCAP_Human2.40655903
17TAF15_26573619_Chip-Seq_HEK293_Human2.35179187
18FUS_26573619_Chip-Seq_HEK293_Human2.32716778
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32534810
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28085359
21* E2F1_21310950_ChIP-Seq_MCF-7_Human2.16181688
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.10884769
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09900085
24EWS_26573619_Chip-Seq_HEK293_Human2.09101026
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07768313
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07664885
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.06688586
28E2F7_22180533_ChIP-Seq_HELA_Human10.1750590
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98740351
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96134954
31REST_21632747_ChIP-Seq_MESCs_Mouse1.93807402
32P300_19829295_ChIP-Seq_ESCs_Human1.93110392
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83770079
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82023328
35CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77883549
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75933691
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.75515279
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73628217
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72831665
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71583580
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.66320185
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65742737
43RNF2_27304074_Chip-Seq_NSC_Mouse1.64853263
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62056698
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60985029
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60533448
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60297185
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60133581
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.59727101
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59354097
51VDR_23849224_ChIP-Seq_CD4+_Human1.59179390
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58848158
53SMAD4_21799915_ChIP-Seq_A2780_Human1.58705706
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56839859
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54456526
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.52811558
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51947464
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49478669
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49057081
60* EST1_17652178_ChIP-ChIP_JURKAT_Human1.48539282
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48289000
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46255550
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45337700
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44816673
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.44257592
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43483841
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43432580
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41382992
69* FOXP3_21729870_ChIP-Seq_TREG_Human1.39048383
70ER_23166858_ChIP-Seq_MCF-7_Human1.38173539
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37258437
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37186164
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36878873
74CIITA_25753668_ChIP-Seq_RAJI_Human1.36807734
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.35939418
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.35814969
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35801538
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34837230
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33734281
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33732783
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.33150858
82XRN2_22483619_ChIP-Seq_HELA_Human1.33061484
83AR_25329375_ChIP-Seq_VCAP_Human1.31705968
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30389363
85CBP_20019798_ChIP-Seq_JUKART_Human1.30389363
86STAT3_23295773_ChIP-Seq_U87_Human1.28913196
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28706118
88* DCP1A_22483619_ChIP-Seq_HELA_Human1.28219605
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27586775
90GABP_19822575_ChIP-Seq_HepG2_Human1.26019096
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24951512
92* ETS1_20019798_ChIP-Seq_JURKAT_Human1.24762348
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23410907
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22801262
95BCAT_22108803_ChIP-Seq_LS180_Human1.20409059
96TCF4_23295773_ChIP-Seq_U87_Human1.20238043
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19958689
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18797543
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17822470
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17475670
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17069414
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16191720
103IRF1_19129219_ChIP-ChIP_H3396_Human1.16185615
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15995164
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14932341
106TTF2_22483619_ChIP-Seq_HELA_Human1.14565944
107KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14110761
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.12823689
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12482763
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12482763
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12131598
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10714699
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10599258
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10423166
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.10245414
116JUN_21703547_ChIP-Seq_K562_Human1.09856076
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.09713468
118TP53_22573176_ChIP-Seq_HFKS_Human1.09594469
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09182673
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.08098700
121RUNX2_22187159_ChIP-Seq_PCA_Human1.06465780
122AR_21572438_ChIP-Seq_LNCaP_Human1.05350707
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.03810896
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.03794167
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.03613410
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03392345
127SOX9_26525672_Chip-Seq_HEART_Mouse1.01463876
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01415794
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01382455
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00161580
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99953236
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.99835366
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99600803
134MYC_22102868_ChIP-Seq_BL_Human0.98567090
135EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98438740
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98438740
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.98347975
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97372324
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97102215
140KDM5A_27292631_Chip-Seq_BREAST_Human0.97053217
141IRF8_21731497_ChIP-ChIP_J774_Mouse0.96028611
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95857250
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95801073
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95599464
145ELK1_19687146_ChIP-ChIP_HELA_Human0.94685855
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93283780
147* NOTCH1_21737748_ChIP-Seq_TLL_Human0.93148906
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92778392
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91894961
150* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90892093
151* MYC_18940864_ChIP-ChIP_HL60_Human0.90815436
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90479607
153SPI1_23547873_ChIP-Seq_NB4_Human0.89392733
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89096491
155* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87815593
156MYB_26560356_Chip-Seq_TH2_Human0.86935601
157MYB_26560356_Chip-Seq_TH1_Human0.85864179
158PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83620978
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83612822
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81303684
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81110035
162HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.80987239
163ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80965317
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80754882
165NFE2_27457419_Chip-Seq_LIVER_Mouse0.79743149
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.79484970
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78635327
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78184222
169VDR_21846776_ChIP-Seq_THP-1_Human0.77483059
170GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76348016
171ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73821400
172TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73625237
173RUNX1_22412390_ChIP-Seq_EML_Mouse0.73260917
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70303842
175STAT1_17558387_ChIP-Seq_HELA_Human0.69207766
176THAP11_20581084_ChIP-Seq_MESCs_Mouse0.66518984
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64709868
178SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64678778
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.63746511
180TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63283136
181MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.62522161
182CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.60316168
183PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.60098429
184PCGF2_27294783_Chip-Seq_NPCs_Mouse0.59958863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.05201439
2MP0008877_abnormal_DNA_methylation4.92493789
3MP0010094_abnormal_chromosome_stability4.82533266
4MP0003693_abnormal_embryo_hatching4.49475138
5MP0008057_abnormal_DNA_replication4.41507303
6MP0003111_abnormal_nucleus_morphology4.23239131
7MP0003077_abnormal_cell_cycle3.68952166
8MP0001929_abnormal_gametogenesis3.29507118
9MP0008058_abnormal_DNA_repair3.03780387
10MP0003880_abnormal_central_pattern3.03258371
11MP0004957_abnormal_blastocyst_morpholog2.95845322
12MP0002210_abnormal_sex_determination2.95363917
13MP0008007_abnormal_cellular_replicative2.76740668
14MP0003698_abnormal_male_reproductive2.75259937
15MP0002736_abnormal_nociception_after2.58820450
16MP0004859_abnormal_synaptic_plasticity2.56121343
17MP0002102_abnormal_ear_morphology2.49901182
18MP0001968_abnormal_touch/_nociception2.47503681
19MP0001145_abnormal_male_reproductive2.43944694
20MP0010307_abnormal_tumor_latency2.38332943
21MP0003646_muscle_fatigue2.33078636
22MP0000778_abnormal_nervous_system2.32405807
23MP0003635_abnormal_synaptic_transmissio2.31840170
24MP0004270_analgesia2.27855619
25MP0000653_abnormal_sex_gland2.24668260
26MP0002822_catalepsy2.24121620
27MP0003718_maternal_effect2.21465756
28MP0002272_abnormal_nervous_system2.15493608
29MP0001529_abnormal_vocalization2.14689009
30MP0005423_abnormal_somatic_nervous2.13682171
31MP0009745_abnormal_behavioral_response2.10362048
32MP0009046_muscle_twitch2.07855059
33MP0003122_maternal_imprinting2.02886119
34MP0002735_abnormal_chemical_nociception2.02841741
35MP0002063_abnormal_learning/memory/cond1.99914348
36MP0002572_abnormal_emotion/affect_behav1.86489811
37MP0003786_premature_aging1.86271965
38MP0000350_abnormal_cell_proliferation1.85996412
39MP0002234_abnormal_pharynx_morphology1.79515577
40MP0006276_abnormal_autonomic_nervous1.77895991
41MP0002161_abnormal_fertility/fecundity1.77864548
42MP0000569_abnormal_digit_pigmentation1.77072947
43MP0002064_seizures1.75681803
44MP0006072_abnormal_retinal_apoptosis1.69227355
45MP0008995_early_reproductive_senescence1.68120838
46MP0004808_abnormal_hematopoietic_stem1.66317128
47MP0003763_abnormal_thymus_physiology1.64774587
48MP0000631_abnormal_neuroendocrine_gland1.62863585
49MP0000049_abnormal_middle_ear1.62540922
50MP0002734_abnormal_mechanical_nocicepti1.60717375
51MP0001486_abnormal_startle_reflex1.58498720
52MP0008932_abnormal_embryonic_tissue1.56700186
53MP0000490_abnormal_crypts_of1.55148019
54MP0002184_abnormal_innervation1.54550365
55MP0005386_behavior/neurological_phenoty1.53070820
56MP0004924_abnormal_behavior1.53070820
57MP0001984_abnormal_olfaction1.52119660
58MP0002653_abnormal_ependyma_morphology1.51611123
59MP0001730_embryonic_growth_arrest1.50142818
60MP0002638_abnormal_pupillary_reflex1.49929101
61MP0001119_abnormal_female_reproductive1.47632587
62MP0002396_abnormal_hematopoietic_system1.47144103
63MP0000516_abnormal_urinary_system1.44844079
64MP0005367_renal/urinary_system_phenotyp1.44844079
65MP0004142_abnormal_muscle_tone1.43636930
66MP0005646_abnormal_pituitary_gland1.43172406
67MP0004885_abnormal_endolymph1.42996397
68MP0001188_hyperpigmentation1.42927601
69MP0005551_abnormal_eye_electrophysiolog1.41253695
70MP0002557_abnormal_social/conspecific_i1.40713106
71MP0005253_abnormal_eye_physiology1.37392455
72MP0002751_abnormal_autonomic_nervous1.37255152
73MP0002019_abnormal_tumor_incidence1.36225343
74MP0000955_abnormal_spinal_cord1.35253604
75MP0000313_abnormal_cell_death1.33673645
76MP0004133_heterotaxia1.33584414
77MP0005394_taste/olfaction_phenotype1.33352635
78MP0005499_abnormal_olfactory_system1.33352635
79MP0003283_abnormal_digestive_organ1.32423510
80MP0002067_abnormal_sensory_capabilities1.31753481
81MP0004811_abnormal_neuron_physiology1.31103779
82MP0005380_embryogenesis_phenotype1.28599070
83MP0001672_abnormal_embryogenesis/_devel1.28599070
84MP0002160_abnormal_reproductive_system1.28531173
85MP0008789_abnormal_olfactory_epithelium1.27612445
86MP0002733_abnormal_thermal_nociception1.24349373
87MP0005076_abnormal_cell_differentiation1.22994757
88MP0001545_abnormal_hematopoietic_system1.21829348
89MP0005397_hematopoietic_system_phenotyp1.21829348
90MP0002882_abnormal_neuron_morphology1.21261379
91MP0002837_dystrophic_cardiac_calcinosis1.20892303
92MP0005187_abnormal_penis_morphology1.18983123
93MP0005645_abnormal_hypothalamus_physiol1.17737619
94MP0001970_abnormal_pain_threshold1.15900694
95MP0002233_abnormal_nose_morphology1.15811176
96MP0001485_abnormal_pinna_reflex1.15182859
97MP0002398_abnormal_bone_marrow1.15120420
98MP0001697_abnormal_embryo_size1.13847862
99MP0000703_abnormal_thymus_morphology1.13607736
100MP0003699_abnormal_female_reproductive1.11557152
101MP0003303_peritoneal_inflammation1.09870402
102MP0001835_abnormal_antigen_presentation1.09507922
103MP0002085_abnormal_embryonic_tissue1.09127732
104MP0006292_abnormal_olfactory_placode1.08818686
105MP0004145_abnormal_muscle_electrophysio1.08769877
106MP0000015_abnormal_ear_pigmentation1.08495698
107MP0003119_abnormal_digestive_system1.08455899
108MP0002152_abnormal_brain_morphology1.07802678
109MP0001502_abnormal_circadian_rhythm1.06599998
110MP0004742_abnormal_vestibular_system1.04818103
111MP0009278_abnormal_bone_marrow1.04745865
112MP0003984_embryonic_growth_retardation1.02674156
113MP0003315_abnormal_perineum_morphology1.01944921
114MP0003787_abnormal_imprinting1.01822065
115MP0000689_abnormal_spleen_morphology1.01688446
116MP0002752_abnormal_somatic_nervous1.01467218
117MP0009333_abnormal_splenocyte_physiolog1.01066621
118MP0005389_reproductive_system_phenotype1.01008523
119MP0001177_atelectasis0.99144709
120MP0002080_prenatal_lethality0.98799503
121MP0002088_abnormal_embryonic_growth/wei0.97493657
122MP0001501_abnormal_sleep_pattern0.97285841
123MP0008872_abnormal_physiological_respon0.96543640
124MP0002066_abnormal_motor_capabilities/c0.95925746
125MP0001905_abnormal_dopamine_level0.95703850
126MP0002722_abnormal_immune_system0.94881616
127MP0002938_white_spotting0.93432015
128MP0002084_abnormal_developmental_patter0.92816451
129MP0003861_abnormal_nervous_system0.91773783
130MP0010352_gastrointestinal_tract_polyps0.91667631
131MP0001986_abnormal_taste_sensitivity0.89349684
132MP0002405_respiratory_system_inflammati0.89257707
133MP0000026_abnormal_inner_ear0.89233467
134MP0003755_abnormal_palate_morphology0.87777328
135MP0000716_abnormal_immune_system0.87673771
136MP0002876_abnormal_thyroid_physiology0.85541803
137MP0002429_abnormal_blood_cell0.84651411
138MP0001440_abnormal_grooming_behavior0.84561115
139MP0001963_abnormal_hearing_physiology0.82331880
140MP0002086_abnormal_extraembryonic_tissu0.81708555
141MP0003121_genomic_imprinting0.81334458
142MP0003123_paternal_imprinting0.81330698
143MP0000685_abnormal_immune_system0.80745431
144MP0002909_abnormal_adrenal_gland0.80011809
145MP0003011_delayed_dark_adaptation0.79518266
146MP0002452_abnormal_antigen_presenting0.79170127
147MP0005195_abnormal_posterior_eye0.77987169
148MP0001270_distended_abdomen0.77028201
149MP0002420_abnormal_adaptive_immunity0.76731786
150MP0005174_abnormal_tail_pigmentation0.75848108
151MP0001819_abnormal_immune_cell0.75783034
152MP0001800_abnormal_humoral_immune0.75543652
153MP0004215_abnormal_myocardial_fiber0.75004409
154MP0004043_abnormal_pH_regulation0.74985066
155MP0003567_abnormal_fetal_cardiomyocyte0.73919860
156MP0000858_altered_metastatic_potential0.70311864
157MP0004197_abnormal_fetal_growth/weight/0.68232322
158MP0002006_tumorigenesis0.67251173
159MP0009785_altered_susceptibility_to0.66612669
160MP0002282_abnormal_trachea_morphology0.65410195
161MP0002163_abnormal_gland_morphology0.65201733
162MP0003890_abnormal_embryonic-extraembry0.64885324
163MP0002723_abnormal_immune_serum0.63913517
164MP0002132_abnormal_respiratory_system0.63168985
165MP0001293_anophthalmia0.63117391
166MP0005395_other_phenotype0.61275699
167MP0005621_abnormal_cell_physiology0.61058856
168MP0002095_abnormal_skin_pigmentation0.60956781
169MP0002419_abnormal_innate_immunity0.58407010
170MP0003115_abnormal_respiratory_system0.57109432
171MP0000579_abnormal_nail_morphology0.57083564
172MP0003937_abnormal_limbs/digits/tail_de0.56107148
173MP0003938_abnormal_ear_development0.55742547
174MP0005000_abnormal_immune_tolerance0.55644415
175MP0001919_abnormal_reproductive_system0.54631701
176MP0000462_abnormal_digestive_system0.54602424
177MP0005384_cellular_phenotype0.52628886
178MP0001849_ear_inflammation0.51282625
179MP0001915_intracranial_hemorrhage0.50963788
180MP0002092_abnormal_eye_morphology0.50383564
181MP0005671_abnormal_response_to0.49192988
182MP0000383_abnormal_hair_follicle0.48842493

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.48381631
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.06593308
3Absent/shortened dynein arms (HP:0200106)6.06593308
4Abnormal respiratory motile cilium physiology (HP:0012261)4.69990494
5Chromsome breakage (HP:0040012)4.57703658
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.52727887
7Nasal polyposis (HP:0100582)4.43177118
8Chronic bronchitis (HP:0004469)4.31147713
9Rhinitis (HP:0012384)4.28507484
10Abnormal respiratory epithelium morphology (HP:0012253)4.23517613
11Abnormal respiratory motile cilium morphology (HP:0005938)4.23517613
12Infertility (HP:0000789)3.77626216
13Hyperventilation (HP:0002883)3.59206641
14Abnormality of chromosome stability (HP:0003220)3.57209737
15Impulsivity (HP:0100710)3.54877766
16Male infertility (HP:0003251)3.48331667
17Focal motor seizures (HP:0011153)3.42144717
18Nephronophthisis (HP:0000090)3.37779028
19Abnormal ciliary motility (HP:0012262)3.34810454
20Abnormality of the nasal mucosa (HP:0000433)3.31887770
2111 pairs of ribs (HP:0000878)3.22386032
22Meckel diverticulum (HP:0002245)3.14390238
23Pendular nystagmus (HP:0012043)3.13924731
24Bronchiectasis (HP:0002110)3.13141673
25Abnormality of the labia minora (HP:0012880)3.11738622
26Abnormal spermatogenesis (HP:0008669)3.09547908
27Retinal dysplasia (HP:0007973)3.09381852
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.01986969
29Bronchitis (HP:0012387)2.98457479
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.98057589
31Abnormality of the ileum (HP:0001549)2.96593945
32Abnormality of the preputium (HP:0100587)2.96206888
33Progressive cerebellar ataxia (HP:0002073)2.93366490
34Broad-based gait (HP:0002136)2.92802918
35Gonadotropin excess (HP:0000837)2.92629874
36Drooling (HP:0002307)2.90439941
37Genetic anticipation (HP:0003743)2.88100667
38Limb dystonia (HP:0002451)2.85700274
39Lissencephaly (HP:0001339)2.83608719
40Selective tooth agenesis (HP:0001592)2.83013554
41Degeneration of anterior horn cells (HP:0002398)2.79313413
42Abnormality of the anterior horn cell (HP:0006802)2.79313413
43Duodenal stenosis (HP:0100867)2.78953184
44Small intestinal stenosis (HP:0012848)2.78953184
45Type II lissencephaly (HP:0007260)2.77027803
46Focal seizures (HP:0007359)2.73662010
47Gait imbalance (HP:0002141)2.71975306
48Sloping forehead (HP:0000340)2.70256165
49True hermaphroditism (HP:0010459)2.69965516
50Hemiparesis (HP:0001269)2.65335449
51Supernumerary spleens (HP:0009799)2.65219928
52Abnormality of the carotid arteries (HP:0005344)2.62020341
53Excessive salivation (HP:0003781)2.61199056
54Chronic hepatic failure (HP:0100626)2.59503875
55Absent speech (HP:0001344)2.58615914
56Medial flaring of the eyebrow (HP:0010747)2.56793753
57Abnormality of the renal medulla (HP:0100957)2.54944942
58Febrile seizures (HP:0002373)2.51631358
59Ectopic kidney (HP:0000086)2.50613969
60Pachygyria (HP:0001302)2.50273270
61Azoospermia (HP:0000027)2.49879734
62Patellar aplasia (HP:0006443)2.46244746
63Congenital primary aphakia (HP:0007707)2.39914076
64Volvulus (HP:0002580)2.36209712
65Inability to walk (HP:0002540)2.35799438
66Abnormality of chromosome segregation (HP:0002916)2.34878467
67Stenosis of the external auditory canal (HP:0000402)2.30922432
68Atonic seizures (HP:0010819)2.29909045
69Clubbing of toes (HP:0100760)2.29531579
70Hypsarrhythmia (HP:0002521)2.29153675
71Epileptic encephalopathy (HP:0200134)2.28116822
72Recurrent otitis media (HP:0000403)2.27325579
73Heterotopia (HP:0002282)2.27234378
74Myelodysplasia (HP:0002863)2.25007327
75Esotropia (HP:0000565)2.24698087
76Nephrogenic diabetes insipidus (HP:0009806)2.23937053
77Birth length less than 3rd percentile (HP:0003561)2.22653138
78EEG with generalized epileptiform discharges (HP:0011198)2.21600864
79Aplasia/Hypoplasia of the patella (HP:0006498)2.21349487
80Polyphagia (HP:0002591)2.20923959
81Epileptiform EEG discharges (HP:0011182)2.20841733
82Recurrent sinusitis (HP:0011108)2.19410268
83Breast carcinoma (HP:0003002)2.17597813
84Fibular hypoplasia (HP:0003038)2.16983288
85Abnormality of the corticospinal tract (HP:0002492)2.16341987
86Abnormal lung lobation (HP:0002101)2.15153014
87Agnosia (HP:0010524)2.14102674
88Morphological abnormality of the pyramidal tract (HP:0002062)2.12926380
89Tubular atrophy (HP:0000092)2.12612729
90Absent epiphyses (HP:0010577)2.12457315
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12457315
92Genital tract atresia (HP:0001827)2.12172566
93Pulmonary fibrosis (HP:0002206)2.12115588
94Bone marrow hypocellularity (HP:0005528)2.10418059
95Prominent nose (HP:0000448)2.10035029
96Recurrent bronchitis (HP:0002837)2.09997324
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09724223
98Short 1st metacarpal (HP:0010034)2.09724223
99Postaxial foot polydactyly (HP:0001830)2.09306464
100Poor suck (HP:0002033)2.08215845
101Spastic tetraplegia (HP:0002510)2.07509370
102Gaze-evoked nystagmus (HP:0000640)2.07494171
103Specific learning disability (HP:0001328)2.07493366
104Premature ovarian failure (HP:0008209)2.07023675
105Abnormality of the duodenum (HP:0002246)2.06503292
106Vaginal atresia (HP:0000148)2.04036537
107Breast hypoplasia (HP:0003187)2.03399434
108Aplasia/Hypoplasia of the tibia (HP:0005772)2.00449777
109J-shaped sella turcica (HP:0002680)1.99642266
110Papillary thyroid carcinoma (HP:0002895)1.99161969
111Urinary bladder sphincter dysfunction (HP:0002839)1.96833148
112Increased nuchal translucency (HP:0010880)1.94506285
113Nephroblastoma (Wilms tumor) (HP:0002667)1.94359953
114Abnormality of the fingertips (HP:0001211)1.94106444
115Optic nerve hypoplasia (HP:0000609)1.93559161
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93095117
117Methylmalonic acidemia (HP:0002912)1.92051580
118High pitched voice (HP:0001620)1.92011727
119Myokymia (HP:0002411)1.91848455
120Short tibia (HP:0005736)1.90899520
121Occipital encephalocele (HP:0002085)1.90165258
122Abnormality of midbrain morphology (HP:0002418)1.90087814
123Molar tooth sign on MRI (HP:0002419)1.90087814
124Renal cortical cysts (HP:0000803)1.90013330
125Cerebellar dysplasia (HP:0007033)1.89952310
126Medulloblastoma (HP:0002885)1.88685113
127Impaired proprioception (HP:0010831)1.88562317
128Dialeptic seizures (HP:0011146)1.88416076
129Narrow forehead (HP:0000341)1.86481813
130Facial cleft (HP:0002006)1.86102659
131Amyotrophic lateral sclerosis (HP:0007354)1.86047747
132Abolished electroretinogram (ERG) (HP:0000550)1.85576802
133Congenital stationary night blindness (HP:0007642)1.85452968
134Facial hemangioma (HP:0000329)1.84739782
135Absent thumb (HP:0009777)1.83889694
136Hyperglycinemia (HP:0002154)1.83588696
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.83183220
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83183220
139Tracheoesophageal fistula (HP:0002575)1.82604788
140Cystic liver disease (HP:0006706)1.80674043
141Embryonal renal neoplasm (HP:0011794)1.80640572
142Optic nerve coloboma (HP:0000588)1.80150813
143Deformed sella turcica (HP:0002681)1.79757184
144Postaxial hand polydactyly (HP:0001162)1.78984488
145Abnormality of the 1st metacarpal (HP:0010009)1.78956204
146Duplicated collecting system (HP:0000081)1.78939580
147Poor coordination (HP:0002370)1.77704863
148Pancreatic fibrosis (HP:0100732)1.76777829
149Abnormality of DNA repair (HP:0003254)1.76290268
150Thyroiditis (HP:0100646)1.75988787
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.75381545
152Recurrent abscess formation (HP:0002722)1.75156415
153Abnormality of the renal cortex (HP:0011035)1.74705677
154Overlapping toe (HP:0001845)1.74392244
155Hyperacusis (HP:0010780)1.73865863
156Renovascular hypertension (HP:0100817)1.73621953
157Intestinal atresia (HP:0011100)1.73604650
158Recurrent bacterial skin infections (HP:0005406)1.71893327
159Sclerocornea (HP:0000647)1.71179641
160Generalized tonic-clonic seizures (HP:0002069)1.70057936
161Dyskinesia (HP:0100660)1.69636314
162Short thumb (HP:0009778)1.69594498
163Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68901399
164Hypoplasia of the brainstem (HP:0002365)1.68901399
165Thyroid-stimulating hormone excess (HP:0002925)1.68475000
166Agitation (HP:0000713)1.68245724
167Cortical dysplasia (HP:0002539)1.66399049
168Disinhibition (HP:0000734)1.65846833
169Severe muscular hypotonia (HP:0006829)1.65761099
170Aplastic anemia (HP:0001915)1.64396317
171Action tremor (HP:0002345)1.64177580
172Colon cancer (HP:0003003)1.64162469
173Chorioretinal atrophy (HP:0000533)1.63257110
174Impaired vibration sensation in the lower limbs (HP:0002166)1.62065960
175Abnormality of alanine metabolism (HP:0010916)1.62044974
176Hyperalaninemia (HP:0003348)1.62044974
177Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62044974
178Urinary urgency (HP:0000012)1.61933005
179Polymicrogyria (HP:0002126)1.61716507
180Oral leukoplakia (HP:0002745)1.61674467
181Megalencephaly (HP:0001355)1.61561821
182Pancreatic cysts (HP:0001737)1.60102942
183Cleft eyelid (HP:0000625)1.59897761
184Overriding aorta (HP:0002623)1.59342120
185Acute myeloid leukemia (HP:0004808)1.59315650
186Triphalangeal thumb (HP:0001199)1.58127788
187Missing ribs (HP:0000921)1.57264369
188Aplasia/Hypoplasia of the tongue (HP:0010295)1.56130349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.00180253
2PDK34.95396415
3PDK44.95396415
4MARK14.53742178
5NEK23.80755680
6MAP3K43.43166910
7TRIM283.13629743
8WEE13.09775895
9BUB12.99066455
10MAP2K72.98878495
11EPHA32.98255054
12PDK22.88373757
13WNK32.85475015
14CASK2.83629646
15TTK2.60668633
16PLK42.53182430
17MAPK132.50288143
18EIF2AK12.45715392
19BCR2.43590177
20TESK12.31010929
21FRK2.28735662
22PINK12.21886995
23DYRK22.08130431
24CHEK22.02958137
25STK102.00086303
26CDK121.98863464
27BRSK21.91634012
28PLK11.89265059
29CCNB11.84738021
30MKNK21.76667406
31MAP4K21.75418712
32ATR1.73024794
33EPHA41.72758500
34DYRK31.62979869
35NTRK21.62651472
36CSNK1G21.61728015
37STK31.61530789
38TNIK1.59828917
39NUAK11.54107075
40CSNK1G31.51631586
41PASK1.51273568
42AURKB1.49431069
43SRPK11.47811544
44STK41.44569862
45CSNK1A1L1.44217962
46MAP2K41.43330000
47BRAF1.43226496
48CSNK1G11.41319444
49SIK21.41217972
50MAP3K61.40827839
51PAK31.39851757
52CHEK11.37590542
53ACVR1B1.37202070
54CDK191.35334306
55EEF2K1.31930285
56MKNK11.29927985
57VRK11.28945149
58CDK71.27729309
59MINK11.22819020
60TLK11.21627378
61ZAK1.20926042
62ADRBK21.20361967
63PRKCG1.19677988
64PRKD31.16603758
65PLK31.15343530
66MAP3K81.14293655
67BRSK11.13457726
68GRK11.12301265
69CDK81.11742770
70PAK61.08422331
71NTRK31.05888926
72ATM1.04814532
73SGK21.03701874
74UHMK11.01205012
75OXSR11.00082349
76PLK20.98770439
77SGK2230.97977716
78SGK4940.97977716
79PRKCE0.94639886
80AURKA0.94166640
81CAMKK20.93508992
82CDK40.93414221
83AKT30.91182877
84CDK50.90160649
85ICK0.88330197
86PHKG20.86821489
87PHKG10.86821489
88MAP4K10.86599071
89YES10.85254073
90CLK10.83071731
91PIM10.82393161
92RPS6KA40.81376082
93EIF2AK20.81310136
94TAOK30.80545913
95EIF2AK30.79289548
96DAPK20.77658267
97RPS6KA50.72502015
98CDK90.72490785
99CAMK2A0.71488839
100IRAK10.69977001
101TESK20.67956131
102INSRR0.65995520
103MELK0.65172750
104PRKCZ0.64908812
105LATS10.64608261
106CDK20.64493260
107KSR10.63148739
108CDK10.58961685
109CAMK2B0.58908955
110TSSK60.58655106
111PKN10.57314227
112STK390.57230948
113NEK10.56852088
114CAMK40.54030709
115PTK2B0.53691453
116BCKDK0.53686865
117CSNK1A10.53375162
118ERBB40.52978383
119MOS0.52850103
120CSNK1D0.52091225
121DYRK1A0.51879265
122RPS6KB20.50493820
123PBK0.50439776
124FER0.49201398
125WNK40.48829658
126JAK30.48584034
127CDK140.46996425
128PAK40.43430109
129CDK180.43369746
130PRKACA0.41972319
131STK160.41642705
132PAK10.41506354
133TYK20.41347375
134TEC0.41172392
135RPS6KB10.39930322
136SGK30.39565636
137SIK30.37919580
138MAP3K100.37811757
139FGFR20.37774212
140PNCK0.37472283
141CSNK1E0.37230995
142CDK150.35664051
143CSNK2A10.35650805
144CAMK10.35318270
145TRPM70.35271386
146BRD40.33763616
147MAP3K140.33206132
148BMPR20.32918401
149ZAP700.32443032
150STK110.32351112
151CDK11A0.31848319
152BMPR1B0.31357710
153PRKACB0.30886103
154MARK30.29882314
155CHUK0.29309214
156IRAK40.28605504
157CDK60.28602767
158CDK30.23840909
159MAP3K50.22859293
160PRKDC0.21489098
161BTK0.21290838
162NLK0.21205625
163STK38L0.20510812
164RPS6KC10.19514429
165RPS6KL10.19514429
166SYK0.19399237
167SCYL20.18015028
168CSNK2A20.17506756
169RPS6KA60.17000932
170ERBB30.16354569
171LYN0.15983412
172MAPK140.15722826
173AKT10.15438631

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.55249228
2Nicotine addiction_Homo sapiens_hsa050334.05096267
3Mismatch repair_Homo sapiens_hsa034303.77898500
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.69604191
5Homologous recombination_Homo sapiens_hsa034403.61615136
6Cell cycle_Homo sapiens_hsa041103.50576476
7Fanconi anemia pathway_Homo sapiens_hsa034603.43628559
8Base excision repair_Homo sapiens_hsa034103.13354705
9RNA transport_Homo sapiens_hsa030133.01738727
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76000653
11Basal transcription factors_Homo sapiens_hsa030222.74488382
12Nucleotide excision repair_Homo sapiens_hsa034202.60673697
13GABAergic synapse_Homo sapiens_hsa047272.49346713
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26760182
15Spliceosome_Homo sapiens_hsa030402.24618212
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24530537
17p53 signaling pathway_Homo sapiens_hsa041152.18720454
18Morphine addiction_Homo sapiens_hsa050322.12832815
19Taste transduction_Homo sapiens_hsa047422.08642436
20Phototransduction_Homo sapiens_hsa047442.07327894
21Non-homologous end-joining_Homo sapiens_hsa034502.07287808
22Systemic lupus erythematosus_Homo sapiens_hsa053222.03170452
23RNA degradation_Homo sapiens_hsa030181.96406276
24Butanoate metabolism_Homo sapiens_hsa006501.89619709
25Synaptic vesicle cycle_Homo sapiens_hsa047211.89163589
26mRNA surveillance pathway_Homo sapiens_hsa030151.84400528
27Pyrimidine metabolism_Homo sapiens_hsa002401.81420146
28Glutamatergic synapse_Homo sapiens_hsa047241.79959822
29Dopaminergic synapse_Homo sapiens_hsa047281.79388041
30Circadian entrainment_Homo sapiens_hsa047131.78316781
31Vitamin B6 metabolism_Homo sapiens_hsa007501.76200807
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72038065
33Protein export_Homo sapiens_hsa030601.68081318
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64039501
35RNA polymerase_Homo sapiens_hsa030201.57243800
36One carbon pool by folate_Homo sapiens_hsa006701.56212696
37Amphetamine addiction_Homo sapiens_hsa050311.53909131
38Collecting duct acid secretion_Homo sapiens_hsa049661.46644954
39Oocyte meiosis_Homo sapiens_hsa041141.43985670
40Pentose phosphate pathway_Homo sapiens_hsa000301.40850462
41Cocaine addiction_Homo sapiens_hsa050301.39327274
42Insulin secretion_Homo sapiens_hsa049111.38073410
43Steroid biosynthesis_Homo sapiens_hsa001001.37900165
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36057737
45Oxidative phosphorylation_Homo sapiens_hsa001901.32728734
46Viral carcinogenesis_Homo sapiens_hsa052031.29291198
47Herpes simplex infection_Homo sapiens_hsa051681.27155541
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25343325
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23177478
50Dorso-ventral axis formation_Homo sapiens_hsa043201.22375352
51Antigen processing and presentation_Homo sapiens_hsa046121.20530699
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19027438
53Olfactory transduction_Homo sapiens_hsa047401.17134064
54Purine metabolism_Homo sapiens_hsa002301.13021232
55Axon guidance_Homo sapiens_hsa043601.12040326
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.11486663
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10970990
58Parkinsons disease_Homo sapiens_hsa050121.10814805
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08630034
60Propanoate metabolism_Homo sapiens_hsa006401.07518186
61Epstein-Barr virus infection_Homo sapiens_hsa051691.05634348
62Serotonergic synapse_Homo sapiens_hsa047261.05386706
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04443664
64Proteasome_Homo sapiens_hsa030501.00569181
65HTLV-I infection_Homo sapiens_hsa051660.99965065
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98989249
67Caffeine metabolism_Homo sapiens_hsa002320.96834267
68Legionellosis_Homo sapiens_hsa051340.95964171
69Long-term depression_Homo sapiens_hsa047300.94514195
70Cholinergic synapse_Homo sapiens_hsa047250.94267443
71Small cell lung cancer_Homo sapiens_hsa052220.93970011
72Primary immunodeficiency_Homo sapiens_hsa053400.88246892
73Measles_Homo sapiens_hsa051620.86827096
74Alcoholism_Homo sapiens_hsa050340.86799390
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85090524
76Nitrogen metabolism_Homo sapiens_hsa009100.84981502
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83949091
78Regulation of autophagy_Homo sapiens_hsa041400.82726187
79Hepatitis B_Homo sapiens_hsa051610.81858066
80Chronic myeloid leukemia_Homo sapiens_hsa052200.81649323
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80677640
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.78833349
83Pancreatic cancer_Homo sapiens_hsa052120.78756319
84Circadian rhythm_Homo sapiens_hsa047100.78630377
85Cardiac muscle contraction_Homo sapiens_hsa042600.78244721
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75938968
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.75748636
88MicroRNAs in cancer_Homo sapiens_hsa052060.75486333
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75377757
90Selenocompound metabolism_Homo sapiens_hsa004500.74967222
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73172006
92Salivary secretion_Homo sapiens_hsa049700.72921046
93Ether lipid metabolism_Homo sapiens_hsa005650.72429214
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72386955
95Influenza A_Homo sapiens_hsa051640.71708799
96cAMP signaling pathway_Homo sapiens_hsa040240.70606428
97Hippo signaling pathway_Homo sapiens_hsa043900.70402358
98Renin secretion_Homo sapiens_hsa049240.66567309
99Alzheimers disease_Homo sapiens_hsa050100.66161010
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.65386447
101N-Glycan biosynthesis_Homo sapiens_hsa005100.65364648
102Leishmaniasis_Homo sapiens_hsa051400.62595442
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62559005
104Peroxisome_Homo sapiens_hsa041460.61187079
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61109337
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60943450
107Apoptosis_Homo sapiens_hsa042100.60220415
108Gastric acid secretion_Homo sapiens_hsa049710.59894325
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59360109
110B cell receptor signaling pathway_Homo sapiens_hsa046620.58887004
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58729847
112beta-Alanine metabolism_Homo sapiens_hsa004100.57236468
113Linoleic acid metabolism_Homo sapiens_hsa005910.56522255
114Oxytocin signaling pathway_Homo sapiens_hsa049210.56475006
115Calcium signaling pathway_Homo sapiens_hsa040200.55991784
116Type II diabetes mellitus_Homo sapiens_hsa049300.53796179
117Toxoplasmosis_Homo sapiens_hsa051450.52471386
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50999108
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50378107
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50009835
121Colorectal cancer_Homo sapiens_hsa052100.49922444
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49578942
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49506543
124Gap junction_Homo sapiens_hsa045400.49239609
125Other glycan degradation_Homo sapiens_hsa005110.48192422
126Hematopoietic cell lineage_Homo sapiens_hsa046400.46878744
127Thyroid cancer_Homo sapiens_hsa052160.46215967
128Fatty acid biosynthesis_Homo sapiens_hsa000610.45099300
129ABC transporters_Homo sapiens_hsa020100.43589197
130Asthma_Homo sapiens_hsa053100.43290325
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.43181888
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43153914
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42934385
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.42680286
135TGF-beta signaling pathway_Homo sapiens_hsa043500.41929562
136Ribosome_Homo sapiens_hsa030100.41280411
137T cell receptor signaling pathway_Homo sapiens_hsa046600.40932300
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40350080
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39569130
140Non-small cell lung cancer_Homo sapiens_hsa052230.38681201
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38507838
142Vibrio cholerae infection_Homo sapiens_hsa051100.38395420
143Prostate cancer_Homo sapiens_hsa052150.36202311
144Arginine and proline metabolism_Homo sapiens_hsa003300.36191067
145Shigellosis_Homo sapiens_hsa051310.35694569
146FoxO signaling pathway_Homo sapiens_hsa040680.35474012
147Wnt signaling pathway_Homo sapiens_hsa043100.34627023
148Long-term potentiation_Homo sapiens_hsa047200.34505263
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34183712
150Metabolic pathways_Homo sapiens_hsa011000.33601181
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32340081
152Viral myocarditis_Homo sapiens_hsa054160.32337263
153Pathways in cancer_Homo sapiens_hsa052000.31297523
154Notch signaling pathway_Homo sapiens_hsa043300.30985499
155Allograft rejection_Homo sapiens_hsa053300.30166341
156Osteoclast differentiation_Homo sapiens_hsa043800.29546972
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28706564
158Tuberculosis_Homo sapiens_hsa051520.26599307
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26089657
160Basal cell carcinoma_Homo sapiens_hsa052170.26056293
161TNF signaling pathway_Homo sapiens_hsa046680.24729008
162Glucagon signaling pathway_Homo sapiens_hsa049220.24574970
163Malaria_Homo sapiens_hsa051440.23192206
164Biosynthesis of amino acids_Homo sapiens_hsa012300.21461018
165HIF-1 signaling pathway_Homo sapiens_hsa040660.21025864
166Huntingtons disease_Homo sapiens_hsa050160.20515621
167Acute myeloid leukemia_Homo sapiens_hsa052210.19241671
168Glycerophospholipid metabolism_Homo sapiens_hsa005640.19008847
169Hedgehog signaling pathway_Homo sapiens_hsa043400.18592710
170Graft-versus-host disease_Homo sapiens_hsa053320.18418651

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