KANSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.39280948
2activated T cell proliferation (GO:0050798)3.82862938
3nuclear pore complex assembly (GO:0051292)3.80180873
4mitotic sister chromatid cohesion (GO:0007064)3.78510385
5regulation of RNA export from nucleus (GO:0046831)3.76512219
6cytoplasmic mRNA processing body assembly (GO:0033962)3.69530451
7dosage compensation (GO:0007549)3.61247848
8histone H3-K4 trimethylation (GO:0080182)3.57637459
9negative regulation of histone methylation (GO:0031061)3.51584244
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.50745572
11neural tube formation (GO:0001841)3.48303737
12histone H3-K4 methylation (GO:0051568)3.46381134
13nuclear pore organization (GO:0006999)3.44781689
14protein K11-linked deubiquitination (GO:0035871)3.42914839
15establishment of protein localization to Golgi (GO:0072600)3.42226063
16piRNA metabolic process (GO:0034587)3.39806750
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35126026
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.35126026
19regulation of translation, ncRNA-mediated (GO:0045974)3.35126026
20histone H3-K9 demethylation (GO:0033169)3.34600247
21protein K48-linked deubiquitination (GO:0071108)3.28051769
22NLS-bearing protein import into nucleus (GO:0006607)3.26715831
23positive regulation of CREB transcription factor activity (GO:0032793)3.24448171
24regulation of nucleobase-containing compound transport (GO:0032239)3.20516729
25positive regulation of developmental pigmentation (GO:0048087)3.19982613
26pericardium development (GO:0060039)3.18962836
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17397551
28negative regulation of cell killing (GO:0031342)3.17397551
29nucleus localization (GO:0051647)3.14979071
30histone H3-K36 demethylation (GO:0070544)3.10436726
31regulation of B cell receptor signaling pathway (GO:0050855)3.09125130
32histone lysine methylation (GO:0034968)3.09047749
33kidney morphogenesis (GO:0060993)3.08756947
34regulation of NFAT protein import into nucleus (GO:0051532)3.08389595
35peptidyl-lysine trimethylation (GO:0018023)3.07958907
36DNA methylation (GO:0006306)3.05337099
37DNA methylation involved in gamete generation (GO:0043046)3.02053707
38glucocorticoid receptor signaling pathway (GO:0042921)3.00412489
39positive thymic T cell selection (GO:0045059)2.99090393
40histone lysine demethylation (GO:0070076)2.98125892
41histone H3-K9 methylation (GO:0051567)2.96713046
42positive regulation of granulocyte differentiation (GO:0030854)2.94061137
43sister chromatid cohesion (GO:0007062)2.91703581
44pore complex assembly (GO:0046931)2.89356278
45protein targeting to Golgi (GO:0000042)2.88494204
46cellular response to ethanol (GO:0071361)2.88045365
47peptidyl-lysine dimethylation (GO:0018027)2.87695758
48negative T cell selection (GO:0043383)2.86437248
49positive regulation of gamma-delta T cell activation (GO:0046645)2.85004755
50histone demethylation (GO:0016577)2.84532143
51negative thymic T cell selection (GO:0045060)2.83384571
52establishment of nucleus localization (GO:0040023)2.82973175
53microtubule anchoring (GO:0034453)2.81687152
54regulation of sister chromatid cohesion (GO:0007063)2.80211458
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79028594
56positive T cell selection (GO:0043368)2.77838717
57rRNA catabolic process (GO:0016075)2.76627423
58mRNA stabilization (GO:0048255)2.76071266
59RNA stabilization (GO:0043489)2.76071266
60protein K63-linked deubiquitination (GO:0070536)2.76063327
61positive regulation of gene expression, epigenetic (GO:0045815)2.75754966
62positive regulation of histone deacetylation (GO:0031065)2.74705449
63regulation of histone H3-K9 methylation (GO:0051570)2.73647370
64stress granule assembly (GO:0034063)2.72758367
65histone methylation (GO:0016571)2.70760272
66genitalia morphogenesis (GO:0035112)2.67547975
67corticosteroid receptor signaling pathway (GO:0031958)2.67214932
68histone H4-K12 acetylation (GO:0043983)2.65639945
69regulation of gamma-delta T cell differentiation (GO:0045586)2.65429106
70* histone H4-K16 acetylation (GO:0043984)2.65217577
71histone deubiquitination (GO:0016578)2.63573927
72N-terminal protein amino acid acetylation (GO:0006474)2.63567033
73thymic T cell selection (GO:0045061)2.63501322
74DNA methylation or demethylation (GO:0044728)2.63298412
75protein demethylation (GO:0006482)2.62676007
76protein dealkylation (GO:0008214)2.62676007
77regulation of pigment cell differentiation (GO:0050932)2.62043987
78gene silencing by RNA (GO:0031047)2.59346939
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58987453
80regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.58492898
81histone H3-K9 modification (GO:0061647)2.57959547
82nucleosome disassembly (GO:0006337)2.57160034
83protein-DNA complex disassembly (GO:0032986)2.57160034
84positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.56702441
85peptidyl-lysine methylation (GO:0018022)2.56418982
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.56001180
87response to interleukin-15 (GO:0070672)2.55718211
88T cell selection (GO:0045058)2.55052659
89positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53482735
90regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53482735
91embryonic hemopoiesis (GO:0035162)2.52930400
92atrial cardiac muscle cell action potential (GO:0086014)2.52727519
93cerebellar Purkinje cell differentiation (GO:0021702)2.52492812
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52311380
95negative regulation of gene expression, epigenetic (GO:0045814)2.52004977
96synapsis (GO:0007129)2.51264159
97gene silencing (GO:0016458)2.49894706
98central nervous system neuron axonogenesis (GO:0021955)2.49787349
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.49323649
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49323649
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49323649
102positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.48018193
103regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.48018193
104interferon-gamma production (GO:0032609)2.47301371
105Golgi to endosome transport (GO:0006895)2.45881326
106regulation of meiosis I (GO:0060631)2.45797392
107regulation of histone H3-K27 methylation (GO:0061085)2.45266511
108lipid translocation (GO:0034204)2.43241494
109phospholipid translocation (GO:0045332)2.43241494
110negative regulation of interleukin-1 beta production (GO:0032691)2.43037592
111* histone H4 acetylation (GO:0043967)2.42244368
112regulation of chromatin silencing (GO:0031935)2.42046778
113regulation of telomere maintenance (GO:0032204)2.41891490
114histone H2A monoubiquitination (GO:0035518)2.41023279
115histone mRNA catabolic process (GO:0071044)2.39600178
116positive regulation of mRNA catabolic process (GO:0061014)2.39487463
117regulation of DNA endoreduplication (GO:0032875)2.38979221
118regulation of gamma-delta T cell activation (GO:0046643)2.38852763
119heterochromatin organization (GO:0070828)2.38084022
120negative regulation of cAMP-mediated signaling (GO:0043951)2.36556949
121intracellular estrogen receptor signaling pathway (GO:0030520)2.36540814
122embryonic foregut morphogenesis (GO:0048617)2.36033949
123regulation of MHC class I biosynthetic process (GO:0045343)2.35578535
124regulation of establishment of cell polarity (GO:2000114)2.34782302
125negative regulation of histone modification (GO:0031057)2.33691076
126reciprocal DNA recombination (GO:0035825)2.32701631
127reciprocal meiotic recombination (GO:0007131)2.32701631
128histone H2A acetylation (GO:0043968)2.32586242
129V(D)J recombination (GO:0033151)2.31818309
130DNA geometric change (GO:0032392)2.31466995
131DNA duplex unwinding (GO:0032508)2.31348336
132regulation of histone methylation (GO:0031060)2.29209973
133regulation of interleukin-12 biosynthetic process (GO:0045075)2.28921127
134interkinetic nuclear migration (GO:0022027)2.28515959
135alternative mRNA splicing, via spliceosome (GO:0000380)2.28099651
136male meiosis (GO:0007140)2.27393881
137protein alkylation (GO:0008213)2.26827923
138protein methylation (GO:0006479)2.26827923
139positive regulation of RNA splicing (GO:0033120)2.26046280
140regulation of gene expression, epigenetic (GO:0040029)2.25937367
141negative regulation of chromatin modification (GO:1903309)2.24710312
142negative regulation of RNA splicing (GO:0033119)2.24440782
143mRNA splice site selection (GO:0006376)2.24293828
144* histone acetylation (GO:0016573)2.23956064
145regulation of mRNA catabolic process (GO:0061013)2.22408520
146positive regulation by host of viral transcription (GO:0043923)2.22260110
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.20836270
148chromatin silencing (GO:0006342)2.20248829
149peptidyl-threonine phosphorylation (GO:0018107)2.19058368
150regulation of histone H3-K4 methylation (GO:0051569)2.18611880
151* internal peptidyl-lysine acetylation (GO:0018393)2.16875733
152monoubiquitinated protein deubiquitination (GO:0035520)2.15804980
153* histone H4-K5 acetylation (GO:0043981)2.15124571
154* histone H4-K8 acetylation (GO:0043982)2.15124571
155mitotic nuclear envelope disassembly (GO:0007077)2.14656372
156negative regulation of mRNA processing (GO:0050686)2.14608994
157regulation of mRNA stability (GO:0043488)2.14495195
158DNA alkylation (GO:0006305)2.14199799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51787707
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.37625464
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.95076948
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78657203
5MYC_22102868_ChIP-Seq_BL_Human3.72618560
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37600374
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26157499
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83934426
9TCF7_22412390_ChIP-Seq_EML_Mouse2.66029028
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.55898059
11KDM2B_26808549_Chip-Seq_DND41_Human2.48289139
12TAF15_26573619_Chip-Seq_HEK293_Human2.47154737
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.46217700
14GBX2_23144817_ChIP-Seq_PC3_Human2.45911669
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.42825795
16ZNF274_21170338_ChIP-Seq_K562_Hela2.37219061
17* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.33936707
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25935372
19VDR_21846776_ChIP-Seq_THP-1_Human2.21614994
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.17909066
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17830783
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15656328
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12280179
24VDR_22108803_ChIP-Seq_LS180_Human2.09063831
25ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06890734
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05313782
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04741022
28AR_21572438_ChIP-Seq_LNCaP_Human2.03459301
29IGF1R_20145208_ChIP-Seq_DFB_Human2.01609345
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95345663
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94948969
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94609766
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90306993
34CIITA_25753668_ChIP-Seq_RAJI_Human1.89702996
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89130926
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89130926
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.88070844
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86435657
39STAT3_23295773_ChIP-Seq_U87_Human1.84418358
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.84095710
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83696743
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.83210372
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82957393
44EWS_26573619_Chip-Seq_HEK293_Human1.81741324
45FUS_26573619_Chip-Seq_HEK293_Human1.81320563
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80934559
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80111271
48MAF_26560356_Chip-Seq_TH1_Human1.79215356
49UTX_26944678_Chip-Seq_JUKART_Human1.78461960
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78318001
51EZH2_22144423_ChIP-Seq_EOC_Human1.72570413
52GATA1_22025678_ChIP-Seq_K562_Human1.72089616
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69560677
54RUNX_20019798_ChIP-Seq_JUKART_Human1.69275981
55TCF4_23295773_ChIP-Seq_U87_Human1.67829641
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67529902
57ER_23166858_ChIP-Seq_MCF-7_Human1.66888723
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65858082
59SCL_19346495_ChIP-Seq_HPC-7_Human1.65572447
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64710205
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64179584
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64066955
63SMAD4_21799915_ChIP-Seq_A2780_Human1.63031979
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60271207
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.59843335
66P300_19829295_ChIP-Seq_ESCs_Human1.57164074
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56596586
68MYB_26560356_Chip-Seq_TH1_Human1.55480127
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.53742712
70MYB_26560356_Chip-Seq_TH2_Human1.52909320
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52457581
72BCAT_22108803_ChIP-Seq_LS180_Human1.52168476
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49764852
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.46184337
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45882730
76KDM2B_26808549_Chip-Seq_K562_Human1.45630279
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45563258
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45490557
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45328698
80TP53_16413492_ChIP-PET_HCT116_Human1.43522889
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43086876
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40252691
83SPI1_23127762_ChIP-Seq_K562_Human1.39391434
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39387724
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.39002429
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.38511454
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37854059
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37722553
89VDR_24763502_ChIP-Seq_THP-1_Human1.37048710
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.35734053
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32366820
92AR_25329375_ChIP-Seq_VCAP_Human1.30162687
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.29403468
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.29399412
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29297088
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28072799
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.26897240
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25080546
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24371337
100RUNX2_22187159_ChIP-Seq_PCA_Human1.24343891
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23208965
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23053103
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22461260
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.21785696
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21130380
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20736165
107AHR_22903824_ChIP-Seq_MCF-7_Human1.19504954
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.18766153
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18470439
110CBP_20019798_ChIP-Seq_JUKART_Human1.18470439
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16439063
112NCOR1_26117541_ChIP-Seq_K562_Human1.15489087
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14421025
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13287589
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12518409
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11569662
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11261078
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11145252
119TCF4_22108803_ChIP-Seq_LS180_Human1.11072650
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09501960
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09118862
122RXR_22108803_ChIP-Seq_LS180_Human1.08449832
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08177342
124KDM2B_26808549_Chip-Seq_REH_Human1.07805209
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07754180
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07743887
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07700207
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.07245947
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.06918395
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.06676609
131RNF2_27304074_Chip-Seq_NSC_Mouse1.05900399
132BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04734756
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03139044
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02975413
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02430223
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00465812
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00078560
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.99040921
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98924277
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98753155
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.98686564
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98549912
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97905954
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96916742
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96902130
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.95534299
147MAF_26560356_Chip-Seq_TH2_Human0.95438159
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95301495
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94479807
150NANOG_21062744_ChIP-ChIP_HESCs_Human0.94341404
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93599754
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.93057355
153REST_21632747_ChIP-Seq_MESCs_Mouse0.92863697
154GATA3_27048872_Chip-Seq_THYMUS_Human0.91646161
155RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91338724
156CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91136436
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.91013105
158AR_19668381_ChIP-Seq_PC3_Human0.90380832
159TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90364572
160EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89884448
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89570811
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88491340
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87492798
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86297236
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85941702
166CREB1_26743006_Chip-Seq_LNCaP_Human0.85170847
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84600775
168* BRD4_25478319_ChIP-Seq_HGPS_Human0.84311147
169CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84193473
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83640513
171RARB_27405468_Chip-Seq_BRAIN_Mouse0.83598865
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82999490
173IRF8_27001747_Chip-Seq_BMDM_Mouse0.82885374
174DROSHA_22980978_ChIP-Seq_HELA_Human0.82327551
175GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82060798
176SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81385569
177RUNX1_27514584_Chip-Seq_MCF-7_Human0.80842796
178KDM5A_27292631_Chip-Seq_BREAST_Human0.80478621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.54613843
2MP0005076_abnormal_cell_differentiation2.99093674
3MP0009278_abnormal_bone_marrow2.65798276
4MP0008057_abnormal_DNA_replication2.46899687
5MP0008877_abnormal_DNA_methylation2.34412741
6MP0003787_abnormal_imprinting2.32357179
7MP0010352_gastrointestinal_tract_polyps2.20013633
8MP0004808_abnormal_hematopoietic_stem2.13290865
9MP0008961_abnormal_basal_metabolism2.05318621
10MP0002396_abnormal_hematopoietic_system2.03810164
11MP0010307_abnormal_tumor_latency2.03043294
12MP0003300_gastrointestinal_ulcer2.01318018
13MP0004381_abnormal_hair_follicle1.91727194
14MP0002009_preneoplasia1.89965497
15MP0003121_genomic_imprinting1.88099557
16MP0002166_altered_tumor_susceptibility1.85508209
17MP0003111_abnormal_nucleus_morphology1.83849777
18MP0010094_abnormal_chromosome_stability1.79087516
19MP0002928_abnormal_bile_duct1.78750036
20MP0002102_abnormal_ear_morphology1.74473637
21MP0000427_abnormal_hair_cycle1.71670847
22MP0005645_abnormal_hypothalamus_physiol1.67766401
23MP0003077_abnormal_cell_cycle1.66073376
24MP0003763_abnormal_thymus_physiology1.64648526
25MP0005075_abnormal_melanosome_morpholog1.60098443
26MP0002735_abnormal_chemical_nociception1.54915873
27MP0000703_abnormal_thymus_morphology1.54157504
28MP0003303_peritoneal_inflammation1.53135132
29MP0003646_muscle_fatigue1.51964588
30MP0000383_abnormal_hair_follicle1.51500124
31MP0000350_abnormal_cell_proliferation1.50249728
32MP0000733_abnormal_muscle_development1.48308523
33MP0002084_abnormal_developmental_patter1.47011121
34MP0005397_hematopoietic_system_phenotyp1.46223753
35MP0001545_abnormal_hematopoietic_system1.46223753
36MP0001486_abnormal_startle_reflex1.45529514
37MP0003890_abnormal_embryonic-extraembry1.44524439
38MP0002877_abnormal_melanocyte_morpholog1.44471058
39MP0002638_abnormal_pupillary_reflex1.41748028
40MP0008007_abnormal_cellular_replicative1.41508901
41MP0004043_abnormal_pH_regulation1.40151483
42MP0002398_abnormal_bone_marrow1.39474660
43MP0004197_abnormal_fetal_growth/weight/1.38362986
44MP0001188_hyperpigmentation1.38151109
45MP0005380_embryogenesis_phenotype1.37150507
46MP0001672_abnormal_embryogenesis/_devel1.37150507
47MP0002006_tumorigenesis1.36754792
48MP0005174_abnormal_tail_pigmentation1.36101671
49MP0003984_embryonic_growth_retardation1.35457744
50MP0005310_abnormal_salivary_gland1.34947859
51MP0002088_abnormal_embryonic_growth/wei1.34604116
52MP0002086_abnormal_extraembryonic_tissu1.32275368
53MP0000428_abnormal_craniofacial_morphol1.30692075
54MP0009703_decreased_birth_body1.28995593
55MP0003122_maternal_imprinting1.28458074
56MP0000631_abnormal_neuroendocrine_gland1.27121840
57MP0002085_abnormal_embryonic_tissue1.26516322
58MP0001501_abnormal_sleep_pattern1.22796303
59MP0001730_embryonic_growth_arrest1.22030451
60MP0003705_abnormal_hypodermis_morpholog1.21055813
61MP0004510_myositis1.20383315
62MP0003172_abnormal_lysosome_physiology1.19173752
63MP0003045_fibrosis1.15559499
64MP0001697_abnormal_embryo_size1.15409587
65MP0001800_abnormal_humoral_immune1.13300389
66MP0002925_abnormal_cardiovascular_devel1.13260378
67MP0005551_abnormal_eye_electrophysiolog1.13116376
68MP0000537_abnormal_urethra_morphology1.12987657
69MP0001915_intracranial_hemorrhage1.10853876
70MP0003935_abnormal_craniofacial_develop1.10334688
71MP0008995_early_reproductive_senescence1.09899228
72MP0003091_abnormal_cell_migration1.09440709
73MP0000371_diluted_coat_color1.08673787
74MP0000778_abnormal_nervous_system1.07966484
75MP0004924_abnormal_behavior1.07159703
76MP0005386_behavior/neurological_phenoty1.07159703
77MP0009115_abnormal_fat_cell1.02851055
78MP0001849_ear_inflammation1.01937546
79MP0001293_anophthalmia1.01884447
80MP0001986_abnormal_taste_sensitivity1.01675716
81MP0004142_abnormal_muscle_tone1.01548764
82MP0003566_abnormal_cell_adhesion1.01199183
83MP0003943_abnormal_hepatobiliary_system0.99400027
84MP0008058_abnormal_DNA_repair0.99351743
85MP0003115_abnormal_respiratory_system0.99263737
86MP0003698_abnormal_male_reproductive0.98423700
87MP0001929_abnormal_gametogenesis0.98382806
88MP0000716_abnormal_immune_system0.97878427
89MP0003195_calcinosis0.97796075
90MP0002210_abnormal_sex_determination0.97446573
91MP0004264_abnormal_extraembryonic_tissu0.95895557
92MP0005253_abnormal_eye_physiology0.95772229
93MP0002722_abnormal_immune_system0.95147218
94MP0005167_abnormal_blood-brain_barrier0.94265913
95MP0004130_abnormal_muscle_cell0.93191804
96MP0001346_abnormal_lacrimal_gland0.92215377
97MP0002080_prenatal_lethality0.92146502
98MP0005671_abnormal_response_to0.92143960
99MP0003567_abnormal_fetal_cardiomyocyte0.91536233
100MP0002420_abnormal_adaptive_immunity0.90397635
101MP0000689_abnormal_spleen_morphology0.90176817
102MP0002653_abnormal_ependyma_morphology0.89068030
103MP0003119_abnormal_digestive_system0.88997864
104MP0000685_abnormal_immune_system0.88491313
105MP0001819_abnormal_immune_cell0.88426809
106MP0009053_abnormal_anal_canal0.87850835
107MP0002067_abnormal_sensory_capabilities0.87562747
108MP0002452_abnormal_antigen_presenting0.87527093
109MP0002092_abnormal_eye_morphology0.87334857
110MP0000015_abnormal_ear_pigmentation0.87302271
111MP0005367_renal/urinary_system_phenotyp0.86478285
112MP0000516_abnormal_urinary_system0.86478285
113MP0010678_abnormal_skin_adnexa0.85959534
114MP0002095_abnormal_skin_pigmentation0.85600985
115MP0000432_abnormal_head_morphology0.84151088
116MP0005623_abnormal_meninges_morphology0.83825879
117MP0004885_abnormal_endolymph0.83005898
118MP0004957_abnormal_blastocyst_morpholog0.82879620
119MP0003693_abnormal_embryo_hatching0.82336201
120MP0003861_abnormal_nervous_system0.81773441
121MP0000372_irregular_coat_pigmentation0.80892952
122MP0010234_abnormal_vibrissa_follicle0.80853091
123MP0001784_abnormal_fluid_regulation0.80803102
124MP0010030_abnormal_orbit_morphology0.79762275
125MP0001145_abnormal_male_reproductive0.79550406
126MP0001286_abnormal_eye_development0.79106334
127MP0002429_abnormal_blood_cell0.79058675
128MP0003385_abnormal_body_wall0.78887873
129MP0001873_stomach_inflammation0.77611867
130MP0000313_abnormal_cell_death0.77565752
131MP0005621_abnormal_cell_physiology0.77279534
132MP0000266_abnormal_heart_morphology0.77207456
133MP0002557_abnormal_social/conspecific_i0.77101798
134MP0002019_abnormal_tumor_incidence0.77084551
135MP0002723_abnormal_immune_serum0.77075815
136MP0005387_immune_system_phenotype0.76957832
137MP0001790_abnormal_immune_system0.76957832
138MP0000653_abnormal_sex_gland0.76780839
139MP0009672_abnormal_birth_weight0.76666094
140MP0002405_respiratory_system_inflammati0.76481535
141MP0004185_abnormal_adipocyte_glucose0.76284895
142MP0006292_abnormal_olfactory_placode0.75683297
143MP0003123_paternal_imprinting0.74707723
144MP0001984_abnormal_olfaction0.72631218
145MP0002063_abnormal_learning/memory/cond0.71400390
146MP0003937_abnormal_limbs/digits/tail_de0.70302262
147MP0003880_abnormal_central_pattern0.70096831
148MP0002733_abnormal_thermal_nociception0.67981298
149MP0005448_abnormal_energy_balance0.67698049
150MP0001440_abnormal_grooming_behavior0.66916001
151MP0008872_abnormal_physiological_respon0.65267482
152MP0004742_abnormal_vestibular_system0.65242586
153MP0001270_distended_abdomen0.64714993
154MP0001970_abnormal_pain_threshold0.64597656
155MP0003136_yellow_coat_color0.63360192
156MP0001119_abnormal_female_reproductive0.62266138
157MP0004133_heterotaxia0.61912179
158MP0003635_abnormal_synaptic_transmissio0.61718661
159MP0002064_seizures0.61406142
160MP0004147_increased_porphyrin_level0.59789975

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of the fingertips (HP:0001211)3.74917739
2Hyperventilation (HP:0002883)3.69236068
3Volvulus (HP:0002580)3.24045024
4Birth length less than 3rd percentile (HP:0003561)3.09573641
5Oligodactyly (hands) (HP:0001180)3.07277574
6Hyperacusis (HP:0010780)3.07085497
7Long eyelashes (HP:0000527)3.00116723
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99023314
9Short 4th metacarpal (HP:0010044)2.99023314
10Protruding tongue (HP:0010808)2.95989845
11Progressive cerebellar ataxia (HP:0002073)2.85218745
12Hypoplastic iliac wings (HP:0002866)2.76360976
13Macroorchidism (HP:0000053)2.68898678
14Fair hair (HP:0002286)2.66122089
15Aplasia/Hypoplasia of the sternum (HP:0006714)2.62691484
16Trigonocephaly (HP:0000243)2.61596304
17Panhypogammaglobulinemia (HP:0003139)2.58044827
18Urethral obstruction (HP:0000796)2.49603371
19Intestinal atresia (HP:0011100)2.46925495
20Heterotopia (HP:0002282)2.43214367
21Pancreatic cysts (HP:0001737)2.37663358
22Renal duplication (HP:0000075)2.33768947
23Increased nuchal translucency (HP:0010880)2.33587139
24Gaze-evoked nystagmus (HP:0000640)2.32660619
25Febrile seizures (HP:0002373)2.30671747
26Diastasis recti (HP:0001540)2.30499776
27Clumsiness (HP:0002312)2.29801480
28Abnormality of the renal medulla (HP:0100957)2.27420265
29Cerebral aneurysm (HP:0004944)2.23717445
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.20653927
31Abnormality of the nasal septum (HP:0000419)2.20457578
32* Narrow palate (HP:0000189)2.18651360
33Truncal obesity (HP:0001956)2.16809593
34Cupped ear (HP:0000378)2.15984454
35Absent speech (HP:0001344)2.14582770
36Neoplasm of the oral cavity (HP:0100649)2.12864167
37Chronic hepatic failure (HP:0100626)2.12781102
38Neoplasm of the adrenal cortex (HP:0100641)2.11976267
39Patellar aplasia (HP:0006443)2.11689953
40Abnormality of the 4th metacarpal (HP:0010012)2.10585671
41Stomach cancer (HP:0012126)2.10499227
42Broad thumb (HP:0011304)2.09930510
43Abnormality of the renal cortex (HP:0011035)2.08669748
44Acute lymphatic leukemia (HP:0006721)2.08347797
45Transitional cell carcinoma of the bladder (HP:0006740)2.07645899
46Progressive inability to walk (HP:0002505)2.07541457
47Broad palm (HP:0001169)2.06840967
48Elfin facies (HP:0004428)2.06602913
49* Widely spaced teeth (HP:0000687)2.05993879
50Astrocytoma (HP:0009592)2.05907326
51Abnormality of the astrocytes (HP:0100707)2.05907326
52Congenital stationary night blindness (HP:0007642)2.05818280
53Chin dimple (HP:0010751)2.04919952
54Obsessive-compulsive behavior (HP:0000722)2.04727710
55Leiomyosarcoma (HP:0100243)2.03932692
56Uterine leiomyosarcoma (HP:0002891)2.03932692
57Generalized hypopigmentation of hair (HP:0011358)2.03619282
58Hepatoblastoma (HP:0002884)2.01485940
59Breast hypoplasia (HP:0003187)2.00924849
60Abnormality of the labia majora (HP:0012881)2.00880665
61Prominent nose (HP:0000448)2.00626678
62Highly arched eyebrow (HP:0002553)2.00408564
63Absent frontal sinuses (HP:0002688)2.00399260
64Cutis marmorata (HP:0000965)1.99533247
65Nephronophthisis (HP:0000090)1.99329303
66Renovascular hypertension (HP:0100817)1.99299617
67Papillary thyroid carcinoma (HP:0002895)1.98785705
68Molar tooth sign on MRI (HP:0002419)1.98093394
69Abnormality of midbrain morphology (HP:0002418)1.98093394
70Vertebral arch anomaly (HP:0008438)1.98009163
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97475766
72Pointed chin (HP:0000307)1.96850787
73Microtia (HP:0008551)1.96202164
74Supernumerary ribs (HP:0005815)1.96043313
75Hypoplastic nipples (HP:0002557)1.95627616
76Poor coordination (HP:0002370)1.92985453
77Broad-based gait (HP:0002136)1.92593563
78Abnormality of the columella (HP:0009929)1.91697754
79Malignant gastrointestinal tract tumors (HP:0006749)1.90469445
80Gastrointestinal carcinoma (HP:0002672)1.90469445
81Bladder neoplasm (HP:0009725)1.90300511
82Bladder carcinoma (HP:0002862)1.90300511
83True hermaphroditism (HP:0010459)1.90183869
84Blue irides (HP:0000635)1.89638101
85Severe combined immunodeficiency (HP:0004430)1.89534555
86Ependymoma (HP:0002888)1.89076734
87Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88748860
88Anal stenosis (HP:0002025)1.88051660
89Shallow orbits (HP:0000586)1.88004749
90Subacute progressive viral hepatitis (HP:0006572)1.87769522
91Aqueductal stenosis (HP:0002410)1.86851027
92Medulloblastoma (HP:0002885)1.86837909
93Dysmetric saccades (HP:0000641)1.85678641
94Gastroesophageal reflux (HP:0002020)1.84847024
95Abnormality of the labia minora (HP:0012880)1.84518091
96Neoplasm of the heart (HP:0100544)1.83499883
97Ectopic kidney (HP:0000086)1.83394238
98Depressed nasal tip (HP:0000437)1.82824554
99Thick eyebrow (HP:0000574)1.82505745
100Hypoplastic ischia (HP:0003175)1.81778566
101Oligodactyly (HP:0012165)1.81741335
102Dislocated radial head (HP:0003083)1.81445489
103Genetic anticipation (HP:0003743)1.80690829
104Abnormality of the pubic bones (HP:0003172)1.80564315
105Abnormal hair whorl (HP:0010721)1.80109563
106Lip pit (HP:0100267)1.79667328
107Drooling (HP:0002307)1.79411244
108Hematochezia (HP:0002573)1.79332699
109Abnormality of incisor morphology (HP:0011063)1.78883979
110Excessive salivation (HP:0003781)1.78745398
111Skin tags (HP:0010609)1.78579481
112Hyperkalemia (HP:0002153)1.78418124
113Glioma (HP:0009733)1.77281083
114Labial hypoplasia (HP:0000066)1.76792746
115Aplasia/Hypoplasia of the patella (HP:0006498)1.76053001
116Syringomyelia (HP:0003396)1.76012962
117Spinal cord lesions (HP:0100561)1.76012962
118Abnormality of the radial head (HP:0003995)1.75739450
119Atonic seizures (HP:0010819)1.74449639
120Abnormality of the aortic arch (HP:0012303)1.74192403
121Hypochromic microcytic anemia (HP:0004840)1.74129874
122Hypoplasia of the maxilla (HP:0000327)1.74008437
123Deep philtrum (HP:0002002)1.73763336
124Abnormality of the ischium (HP:0003174)1.73165301
125Pancreatic fibrosis (HP:0100732)1.73132340
126Urinary bladder sphincter dysfunction (HP:0002839)1.71701844
127Hypoplastic female external genitalia (HP:0012815)1.71117325
128Overriding aorta (HP:0002623)1.68533920
129Flat cornea (HP:0007720)1.67648112
130Broad phalanges of the hand (HP:0009768)1.67093038
131Midline defect of the nose (HP:0004122)1.67002865
132T lymphocytopenia (HP:0005403)1.66925891
133Impulsivity (HP:0100710)1.66198464
134Acute myeloid leukemia (HP:0004808)1.66151294
135Abnormality of the diencephalon (HP:0010662)1.65559819
136Abnormality of chromosome stability (HP:0003220)1.64008234
137Bowel diverticulosis (HP:0005222)1.63702658
138Tapered finger (HP:0001182)1.63473273
139Long palpebral fissure (HP:0000637)1.63236535
140Supernumerary bones of the axial skeleton (HP:0009144)1.62990741
141Intestinal fistula (HP:0100819)1.62908236
142Skull defect (HP:0001362)1.62669166
143Abnormality of chromosome segregation (HP:0002916)1.62154127
144Lissencephaly (HP:0001339)1.61783660
145Recurrent cutaneous fungal infections (HP:0011370)1.61343317
146Chronic mucocutaneous candidiasis (HP:0002728)1.61343317
147Low anterior hairline (HP:0000294)1.59408038
148Deep palmar crease (HP:0006191)1.59231274
149Recurrent viral infections (HP:0004429)1.58917128
150Aortic aneurysm (HP:0004942)1.58442323
151Neonatal hypoglycemia (HP:0001998)1.58266242
152Proximal placement of thumb (HP:0009623)1.57806556
153Sandal gap (HP:0001852)1.57328386
154Limited elbow extension (HP:0001377)1.57124484
155Deviation of the thumb (HP:0009603)1.57050851
156Basal cell carcinoma (HP:0002671)1.56945468
157Hypoplastic labia majora (HP:0000059)1.55964317
158Tented upper lip vermilion (HP:0010804)1.55579136
159Abnormal number of incisors (HP:0011064)1.54438384
160Abnormality of T cell number (HP:0011839)1.53688923
161Neoplasm of striated muscle (HP:0009728)1.53497855
162Large earlobe (HP:0009748)1.53486110
163Abnormality of the intervertebral disk (HP:0005108)1.52710167
164Broad finger (HP:0001500)1.51960022
165Smooth philtrum (HP:0000319)1.50027830
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49960826
167Rib fusion (HP:0000902)1.46520695
168Spina bifida occulta (HP:0003298)1.46024333
169Somatic mutation (HP:0001428)1.45631310
170Thyroiditis (HP:0100646)1.45586805
171Dental malocclusion (HP:0000689)1.45579611
172Short 5th finger (HP:0009237)1.44597015
173Short philtrum (HP:0000322)1.44172316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.66708827
2FRK4.66176776
3AKT33.64302718
4ACVR1B3.58073477
5MAP3K103.35922473
6BRD43.34772170
7PNCK2.31502276
8BMPR1B2.31224964
9NLK2.29524373
10CASK2.21875223
11CAMK1G2.18510738
12CAMK1D2.09804462
13MAP4K11.98822960
14EEF2K1.96746288
15CDC71.87544909
16ICK1.83193735
17LATS11.71903945
18FGFR31.64658149
19SIK21.61338048
20MAPK131.60076522
21TNIK1.58755762
22RIPK11.49046518
23MTOR1.45745033
24TYRO31.41447087
25DMPK1.39984224
26PDGFRA1.38293565
27NEK21.37712427
28TRIB31.36215138
29CDK61.35895216
30SGK31.35572015
31SGK2231.34967016
32SGK4941.34967016
33STK101.33208459
34WNK31.30968750
35ALK1.30880939
36PTK61.30038577
37CDK91.29501166
38MAP3K41.25534696
39CHUK1.21204251
40TXK1.19350111
41ATR1.14246388
42PDGFRB1.07158515
43TAOK11.04669305
44HIPK21.00329295
45PRKD31.00146085
46SGK20.99092073
47CDK40.98319966
48STK30.97981604
49SCYL20.97574169
50JAK10.97280415
51MELK0.96348873
52TNK20.95072883
53TGFBR10.95030069
54PIM10.93699646
55FGFR20.92734066
56PKN20.91941007
57STK38L0.91494653
58DAPK20.89191048
59INSRR0.88880310
60MARK10.88514554
61WNK10.88363816
62NTRK20.85449809
63OXSR10.84618632
64DYRK30.83479836
65CHEK10.83400007
66JAK30.82421399
67ITK0.80367134
68ATM0.79679675
69TRPM70.78862467
70CDK20.78491270
71CAMKK20.78055100
72MKNK10.75679194
73RPS6KA40.74437838
74CSK0.74147060
75ZAK0.74009220
76KSR10.73976572
77CAMKK10.73834318
78PRKCH0.73208711
79MAP3K70.73151015
80PTK2B0.71786212
81CDC42BPA0.71563193
82ZAP700.70605955
83CDK70.68964943
84HCK0.68906107
85MARK30.68698945
86TYK20.68633079
87STK40.68585651
88TEC0.68528120
89FGFR10.68436971
90BMX0.68232988
91MARK20.67985813
92IRAK10.67476904
93PAK30.64019679
94MAPK100.63860150
95CAMK40.63741907
96MAP3K60.63161741
97SIK30.62604745
98MAPK140.62458837
99PRKD20.61186154
100STK110.60996222
101CAMK10.60252726
102MAPK80.58120014
103CDK30.57288077
104MAP3K20.56936637
105RET0.56013115
106PAK20.55788339
107GSK3B0.55654179
108BTK0.55080654
109CDK10.54828501
110PRKAA20.54523900
111TTN0.54413149
112MAPK10.54028855
113MAP3K140.53395591
114SGK10.53154405
115GRK60.52844045
116CHEK20.52714565
117NUAK10.52382451
118MAP3K130.51939718
119MAP2K40.51144947
120PAK60.50772804
121LCK0.50439237
122CSNK1D0.50438570
123UHMK10.50155410
124STK380.49740477
125ERBB20.49234616
126PRKDC0.49189242
127NTRK30.47975500
128MKNK20.47766165
129EPHA30.46953156
130AKT10.46820564
131SIK10.46484358
132TAOK30.46083938
133JAK20.46028051
134YES10.46003617
135RPS6KA20.45914929
136PASK0.45867564
137DYRK1A0.45643132
138PRKCZ0.44836369
139RPS6KB10.44115313
140MAPK70.44023787
141PRKAA10.43954874
142CSF1R0.43869606
143BLK0.43437047
144FGR0.41689995
145CDK190.41005706
146STK390.39400177
147NEK60.37527001
148SYK0.36956470
149FES0.36785933
150PIK3CA0.34565060

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.16727576
2Chronic myeloid leukemia_Homo sapiens_hsa052201.64374269
3B cell receptor signaling pathway_Homo sapiens_hsa046621.51761870
4mTOR signaling pathway_Homo sapiens_hsa041501.46718281
5Colorectal cancer_Homo sapiens_hsa052101.43760288
6T cell receptor signaling pathway_Homo sapiens_hsa046601.42315106
7mRNA surveillance pathway_Homo sapiens_hsa030151.41331143
8Lysine degradation_Homo sapiens_hsa003101.41282794
9ABC transporters_Homo sapiens_hsa020101.39883948
10Notch signaling pathway_Homo sapiens_hsa043301.38475762
11Primary immunodeficiency_Homo sapiens_hsa053401.36502504
12MicroRNAs in cancer_Homo sapiens_hsa052061.35785758
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33528879
14Endometrial cancer_Homo sapiens_hsa052131.32335462
15Neurotrophin signaling pathway_Homo sapiens_hsa047221.32245805
16Dorso-ventral axis formation_Homo sapiens_hsa043201.29751997
17Nicotine addiction_Homo sapiens_hsa050331.26853917
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26011593
19Type II diabetes mellitus_Homo sapiens_hsa049301.23695021
20Acute myeloid leukemia_Homo sapiens_hsa052211.21090756
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19324125
22Non-small cell lung cancer_Homo sapiens_hsa052231.19235183
23Osteoclast differentiation_Homo sapiens_hsa043801.19046124
24Adherens junction_Homo sapiens_hsa045201.18266850
25Pancreatic cancer_Homo sapiens_hsa052121.17900600
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17227780
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.16234495
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16130858
29Small cell lung cancer_Homo sapiens_hsa052221.13833318
30Long-term depression_Homo sapiens_hsa047301.11780025
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11007041
32Glioma_Homo sapiens_hsa052141.10741204
33Regulation of autophagy_Homo sapiens_hsa041401.10577299
34Basal transcription factors_Homo sapiens_hsa030221.10244849
35HTLV-I infection_Homo sapiens_hsa051661.08609819
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08103345
37Cell cycle_Homo sapiens_hsa041101.07243052
38Viral myocarditis_Homo sapiens_hsa054161.06540978
39Measles_Homo sapiens_hsa051621.05574257
40Prostate cancer_Homo sapiens_hsa052151.05078236
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03762426
42Basal cell carcinoma_Homo sapiens_hsa052171.03355932
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02549013
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02244436
45Hepatitis B_Homo sapiens_hsa051611.00915547
46Proteoglycans in cancer_Homo sapiens_hsa052050.99050405
47Linoleic acid metabolism_Homo sapiens_hsa005910.99021732
48Cholinergic synapse_Homo sapiens_hsa047250.97664074
49Herpes simplex infection_Homo sapiens_hsa051680.97646249
50Toxoplasmosis_Homo sapiens_hsa051450.97301044
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97273698
52FoxO signaling pathway_Homo sapiens_hsa040680.96829022
53Renal cell carcinoma_Homo sapiens_hsa052110.95534833
54Prolactin signaling pathway_Homo sapiens_hsa049170.94978048
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94606135
56ErbB signaling pathway_Homo sapiens_hsa040120.94329509
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94171450
58Hippo signaling pathway_Homo sapiens_hsa043900.93801259
59Leishmaniasis_Homo sapiens_hsa051400.92151192
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92086592
61Wnt signaling pathway_Homo sapiens_hsa043100.91045540
62Viral carcinogenesis_Homo sapiens_hsa052030.90663626
63Phototransduction_Homo sapiens_hsa047440.90593009
64VEGF signaling pathway_Homo sapiens_hsa043700.90475664
65Estrogen signaling pathway_Homo sapiens_hsa049150.89790884
66Taste transduction_Homo sapiens_hsa047420.88536426
67MAPK signaling pathway_Homo sapiens_hsa040100.88482002
68Chemokine signaling pathway_Homo sapiens_hsa040620.86829997
69Antigen processing and presentation_Homo sapiens_hsa046120.85984525
70Morphine addiction_Homo sapiens_hsa050320.85320891
71Hedgehog signaling pathway_Homo sapiens_hsa043400.84578337
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84567745
73TNF signaling pathway_Homo sapiens_hsa046680.84408546
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83724234
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.82739956
76Serotonergic synapse_Homo sapiens_hsa047260.82471506
77Choline metabolism in cancer_Homo sapiens_hsa052310.81716255
78Glutamatergic synapse_Homo sapiens_hsa047240.81199939
79Pathways in cancer_Homo sapiens_hsa052000.80350598
80Platelet activation_Homo sapiens_hsa046110.79700444
81Circadian entrainment_Homo sapiens_hsa047130.79382084
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.79381438
83Long-term potentiation_Homo sapiens_hsa047200.79188574
84Influenza A_Homo sapiens_hsa051640.79065700
85Inositol phosphate metabolism_Homo sapiens_hsa005620.78877417
86Insulin resistance_Homo sapiens_hsa049310.78073286
87Ether lipid metabolism_Homo sapiens_hsa005650.77975378
88RNA transport_Homo sapiens_hsa030130.76847961
89Amphetamine addiction_Homo sapiens_hsa050310.76789213
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.76342504
91Focal adhesion_Homo sapiens_hsa045100.76193269
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76149472
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.75733033
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75149950
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75097833
96Glycerolipid metabolism_Homo sapiens_hsa005610.75007474
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74596364
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74422308
99p53 signaling pathway_Homo sapiens_hsa041150.74227655
100Apoptosis_Homo sapiens_hsa042100.73783884
101Oocyte meiosis_Homo sapiens_hsa041140.73663974
102TGF-beta signaling pathway_Homo sapiens_hsa043500.73091535
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.71696541
104RNA degradation_Homo sapiens_hsa030180.71312013
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71249094
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70213904
107Dopaminergic synapse_Homo sapiens_hsa047280.70045675
108Calcium signaling pathway_Homo sapiens_hsa040200.69984969
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69943305
110Thyroid cancer_Homo sapiens_hsa052160.69780629
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69559287
112Epstein-Barr virus infection_Homo sapiens_hsa051690.69361705
113Rap1 signaling pathway_Homo sapiens_hsa040150.68543905
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.68175984
115Olfactory transduction_Homo sapiens_hsa047400.67951244
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66076769
117Spliceosome_Homo sapiens_hsa030400.65419539
118Melanogenesis_Homo sapiens_hsa049160.65340317
119Base excision repair_Homo sapiens_hsa034100.65141102
120Insulin secretion_Homo sapiens_hsa049110.65118387
121Circadian rhythm_Homo sapiens_hsa047100.64769842
122Cocaine addiction_Homo sapiens_hsa050300.64029390
123Oxytocin signaling pathway_Homo sapiens_hsa049210.63552806
124Insulin signaling pathway_Homo sapiens_hsa049100.63302668
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.63035609
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.62932660
127Endocytosis_Homo sapiens_hsa041440.62887079
128Fanconi anemia pathway_Homo sapiens_hsa034600.61599350
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61391262
130cAMP signaling pathway_Homo sapiens_hsa040240.60109883
131Axon guidance_Homo sapiens_hsa043600.60067668
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59144325
133Ras signaling pathway_Homo sapiens_hsa040140.58466262
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58457801
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58204387
136Butanoate metabolism_Homo sapiens_hsa006500.56880313

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