KANK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)4.98023012
2extracellular matrix assembly (GO:0085029)4.56930849
3plasma membrane repair (GO:0001778)3.98774643
4basement membrane organization (GO:0071711)3.97356424
5extracellular fibril organization (GO:0043206)3.95227303
6paraxial mesoderm development (GO:0048339)3.93158882
7cardiac myofibril assembly (GO:0055003)3.86514890
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.80569879
9protein heterotrimerization (GO:0070208)3.76390919
10kidney mesenchyme development (GO:0072074)3.71956353
11positive regulation of fatty acid beta-oxidation (GO:0032000)3.67937634
12metanephric mesenchyme development (GO:0072075)3.63265079
13collagen fibril organization (GO:0030199)3.53793288
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49122955
15negative regulation of fibrinolysis (GO:0051918)3.47416644
16fibril organization (GO:0097435)3.35981969
17type B pancreatic cell proliferation (GO:0044342)3.29320804
18atrioventricular valve morphogenesis (GO:0003181)3.26840668
19virion attachment to host cell (GO:0019062)3.26758552
20adhesion of symbiont to host cell (GO:0044650)3.26758552
21endocardial cushion development (GO:0003197)3.25142013
22peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.24706795
23sarcomere organization (GO:0045214)3.24496060
24epithelial cell-cell adhesion (GO:0090136)3.24076033
25epoxygenase P450 pathway (GO:0019373)3.23776278
26glomerular basement membrane development (GO:0032836)3.22604389
27endodermal cell differentiation (GO:0035987)3.21691945
28regulation of integrin-mediated signaling pathway (GO:2001044)3.19415764
29barbed-end actin filament capping (GO:0051016)3.19392555
30apoptotic cell clearance (GO:0043277)3.17945960
31regulation of hippo signaling (GO:0035330)3.15697324
32hippo signaling (GO:0035329)3.14559094
33vascular endothelial growth factor signaling pathway (GO:0038084)3.13628277
34regulation of fatty acid beta-oxidation (GO:0031998)3.12603459
35blood vessel maturation (GO:0001955)3.12066595
36bone trabecula formation (GO:0060346)3.10176140
37cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.07471465
38regulation of tight junction assembly (GO:2000810)3.07297764
39carnitine shuttle (GO:0006853)3.06993639
40venous blood vessel morphogenesis (GO:0048845)3.06842144
41cell migration involved in sprouting angiogenesis (GO:0002042)3.05085086
42mesenchymal-epithelial cell signaling (GO:0060638)3.03715900
43myofibril assembly (GO:0030239)3.03205355
44positive regulation of fatty acid oxidation (GO:0046321)3.02551650
45chondrocyte proliferation (GO:0035988)3.01920823
46fatty acid transmembrane transport (GO:1902001)3.01772735
47polarized epithelial cell differentiation (GO:0030859)3.01392311
48keratan sulfate catabolic process (GO:0042340)3.01149390
49pericardium development (GO:0060039)2.96174294
50cellular response to vitamin (GO:0071295)2.96020634
51multicellular organismal macromolecule metabolic process (GO:0044259)2.94187476
52regulation of fibrinolysis (GO:0051917)2.92653406
53regulation of SMAD protein import into nucleus (GO:0060390)2.92388294
54collagen catabolic process (GO:0030574)2.92192155
55lymphangiogenesis (GO:0001946)2.91475646
56adhesion of symbiont to host (GO:0044406)2.91293907
57adherens junction assembly (GO:0034333)2.90299865
58bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90160875
59cell-substrate junction assembly (GO:0007044)2.88568972
60positive regulation of SMAD protein import into nucleus (GO:0060391)2.88099420
61smooth muscle tissue development (GO:0048745)2.87751086
62renal filtration (GO:0097205)2.85273137
63establishment of apical/basal cell polarity (GO:0035089)2.84899216
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84161427
65planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83583540
66neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.83163207
67negative regulation of smooth muscle cell migration (GO:0014912)2.81698780
68lysine catabolic process (GO:0006554)2.80922642
69lysine metabolic process (GO:0006553)2.80922642
70multicellular organismal metabolic process (GO:0044236)2.79683966
71regulation of the force of heart contraction (GO:0002026)2.79636330
72cardiac muscle cell development (GO:0055013)2.77508039
73retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77458719
74stress fiber assembly (GO:0043149)2.76714282
75extracellular matrix disassembly (GO:0022617)2.76628351
76sequestering of extracellular ligand from receptor (GO:0035581)2.76555880
77glomerular filtration (GO:0003094)2.75178472
78negative regulation of fatty acid transport (GO:2000192)2.75162223
79negative regulation of chondrocyte differentiation (GO:0032331)2.72694405
80regulation of fatty acid oxidation (GO:0046320)2.72196894
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.71846648
82endothelial cell morphogenesis (GO:0001886)2.71148949
83regulation of cardioblast differentiation (GO:0051890)2.70959181
84negative regulation of protein localization to cell surface (GO:2000009)2.70950438
85dermatan sulfate biosynthetic process (GO:0030208)2.70411607
86blood vessel endothelial cell migration (GO:0043534)2.70270622
87negative regulation of heart growth (GO:0061117)2.68562128
88negative regulation of cardiac muscle tissue growth (GO:0055022)2.68562128
89dermatan sulfate metabolic process (GO:0030205)2.68353704
90multicellular organismal catabolic process (GO:0044243)2.66872011
91anterior/posterior axis specification, embryo (GO:0008595)2.65975734
92positive regulation of endothelial cell apoptotic process (GO:2000353)2.65599471
93extracellular matrix organization (GO:0030198)2.63976843
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63922646
95cell-substrate adherens junction assembly (GO:0007045)2.63481612
96focal adhesion assembly (GO:0048041)2.63481612
97cardiac cell development (GO:0055006)2.63325009
98extracellular structure organization (GO:0043062)2.62881419
99endothelial cell chemotaxis (GO:0035767)2.61774892
100cGMP-mediated signaling (GO:0019934)2.61082205
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59804538
102trabecula formation (GO:0060343)2.59614302
103cell adhesion mediated by integrin (GO:0033627)2.57937514
104branching involved in salivary gland morphogenesis (GO:0060445)2.57511288
105craniofacial suture morphogenesis (GO:0097094)2.57249568
106sulfur amino acid catabolic process (GO:0000098)2.57185023
107actin filament depolymerization (GO:0030042)2.56678802
108positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56551708
109vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55743488
110alpha-linolenic acid metabolic process (GO:0036109)2.55588955
111actomyosin structure organization (GO:0031032)2.54903105
112muscle cell migration (GO:0014812)2.54686918
113peptidyl-glutamic acid carboxylation (GO:0017187)2.54470594
114protein carboxylation (GO:0018214)2.54470594
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.54012905
116skin morphogenesis (GO:0043589)2.53872086
117notochord development (GO:0030903)2.53789282
118actin-mediated cell contraction (GO:0070252)2.53699759
119regulation of posttranscriptional gene silencing (GO:0060147)2.53308606
120regulation of gene silencing by miRNA (GO:0060964)2.53308606
121regulation of gene silencing by RNA (GO:0060966)2.53308606
122low-density lipoprotein particle clearance (GO:0034383)2.52499163
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.52106661
124axon extension involved in axon guidance (GO:0048846)2.52106661
125cell proliferation involved in metanephros development (GO:0072203)2.52103480
126fibroblast migration (GO:0010761)2.50986899
127regulation of protein activation cascade (GO:2000257)2.49773332
128protein localization to cell surface (GO:0034394)2.49579137
129regulation of p38MAPK cascade (GO:1900744)2.49392921
130tooth mineralization (GO:0034505)2.49238900
131cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49145174
132negative regulation of fatty acid biosynthetic process (GO:0045717)2.48060056
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.47550645
134mesenchymal cell differentiation involved in kidney development (GO:0072161)2.47383053
135mesenchymal cell differentiation involved in renal system development (GO:2001012)2.47383053
136gap junction assembly (GO:0016264)2.47017928
137muscle filament sliding (GO:0030049)2.46525658
138actin-myosin filament sliding (GO:0033275)2.46525658
139heart trabecula formation (GO:0060347)2.46323637
140embryonic placenta development (GO:0001892)2.45889136
141regulation of complement activation (GO:0030449)2.45879933
142protein hydroxylation (GO:0018126)2.45760118
143regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45573216
144endocrine hormone secretion (GO:0060986)2.45354986
145anatomical structure regression (GO:0060033)2.45207386
146lung vasculature development (GO:0060426)2.44894465
147outflow tract septum morphogenesis (GO:0003148)2.44485978
148negative regulation of catenin import into nucleus (GO:0035414)2.43996720
1494-hydroxyproline metabolic process (GO:0019471)2.43862660
150collagen metabolic process (GO:0032963)2.43791126
151substrate adhesion-dependent cell spreading (GO:0034446)2.41731788
1522-oxoglutarate metabolic process (GO:0006103)2.41532113
153midgut development (GO:0007494)2.40931597
154regulation of cholesterol homeostasis (GO:2000188)2.39513104
155glyoxylate metabolic process (GO:0046487)2.36981258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31688355
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19595333
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.55105436
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.29259931
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.18326194
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.16829527
7CLOCK_20551151_ChIP-Seq_293T_Human3.06962712
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91675690
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.74305649
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.64141153
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.52141224
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51118750
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44238824
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41471026
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41471026
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41471026
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31315264
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28776671
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.08280745
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03565986
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.02747998
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.00992642
23* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00314472
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95100665
25TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92786979
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89758546
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.87265714
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86693141
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.85660768
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.85660768
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83594554
32ZNF263_19887448_ChIP-Seq_K562_Human1.81766197
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79616427
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77859364
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.77326483
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.75334012
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74531430
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.73947361
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73108575
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73108575
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69365313
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69116093
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67669585
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66458703
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64435541
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63226065
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62086953
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60368391
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58015515
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57710871
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56777398
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55540112
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52602761
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52518371
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.49338926
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47182900
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46330700
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45337715
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44673476
60SMC3_22415368_ChIP-Seq_MEFs_Mouse1.43867210
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41601186
62RACK7_27058665_Chip-Seq_MCF-7_Human1.41495706
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41416476
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41092034
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40240493
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39667847
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.38594679
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38336175
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34553619
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33342246
71ATF3_27146783_Chip-Seq_COLON_Human1.33201399
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33030194
73* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32526816
74ISL1_27105846_Chip-Seq_CPCs_Mouse1.32318994
75CJUN_26792858_Chip-Seq_BT549_Human1.32028169
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30118891
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29545362
78BRD4_25478319_ChIP-Seq_HGPS_Human1.28780482
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28597257
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28461234
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28461234
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26315287
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25990335
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25784454
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.25207731
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24603091
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.24549920
88TP53_16413492_ChIP-PET_HCT116_Human1.23614479
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23071659
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.22458743
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21947918
92* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21629487
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.21067063
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20340859
95SA1_22415368_ChIP-Seq_MEFs_Mouse1.19541376
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18704141
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18406915
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18068133
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.16861213
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15378682
101AHR_22903824_ChIP-Seq_MCF-7_Human1.14121494
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13734186
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13252789
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.12573012
105TP53_18474530_ChIP-ChIP_U2OS_Human1.11747805
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11693464
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11647973
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11610096
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.11256060
110LXR_22292898_ChIP-Seq_THP-1_Human1.10383566
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09759487
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09074520
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08487714
114KDM2B_26808549_Chip-Seq_K562_Human1.07621340
115TP53_22127205_ChIP-Seq_IMR90_Human1.07566370
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07412783
117FOXM1_23109430_ChIP-Seq_U2OS_Human1.07206487
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06558875
119* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05778492
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.05607397
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05481376
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05354123
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03772264
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03606417
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03370021
126WT1_19549856_ChIP-ChIP_CCG9911_Human1.02353832
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.01383152
128* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99983630
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99783084
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99783084
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98696594
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98659413
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98275936
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97927864
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.97549089
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97306595
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.96984056
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96569267
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96065661
140NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95410027
141* TP53_23651856_ChIP-Seq_MEFs_Mouse0.94485579
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94168427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.02684396
2MP0003705_abnormal_hypodermis_morpholog4.02253217
3MP0005275_abnormal_skin_tensile3.16637159
4MP0005503_abnormal_tendon_morphology2.91819768
5MP0004084_abnormal_cardiac_muscle2.69334599
6MP0002837_dystrophic_cardiac_calcinosis2.66511602
7MP0004272_abnormal_basement_membrane2.58673568
8MP0003279_aneurysm2.57548571
9MP0005623_abnormal_meninges_morphology2.34672550
10MP0000751_myopathy2.33835586
11MP0010368_abnormal_lymphatic_system2.22724304
12MP0003566_abnormal_cell_adhesion2.11353511
13MP0001958_emphysema1.98512595
14MP0001542_abnormal_bone_strength1.94580218
15MP0000013_abnormal_adipose_tissue1.94027803
16MP0010030_abnormal_orbit_morphology1.91830133
17MP0000750_abnormal_muscle_regeneration1.80358654
18MP0005330_cardiomyopathy1.75100152
19MP0002139_abnormal_hepatobiliary_system1.69991136
20MP0004087_abnormal_muscle_fiber1.68010580
21MP0004036_abnormal_muscle_relaxation1.61081028
22MP0009384_cardiac_valve_regurgitation1.60972901
23MP0006138_congestive_heart_failure1.58961647
24MP0005595_abnormal_vascular_smooth1.58745399
25MP0009053_abnormal_anal_canal1.58718706
26MP0010352_gastrointestinal_tract_polyps1.56278423
27MP0000733_abnormal_muscle_development1.53540913
28MP0010630_abnormal_cardiac_muscle1.53214152
29MP0009780_abnormal_chondrocyte_physiolo1.51301318
30MP0002108_abnormal_muscle_morphology1.49456119
31MP0005085_abnormal_gallbladder_physiolo1.47871112
32MP0005023_abnormal_wound_healing1.47266951
33MP0000749_muscle_degeneration1.43815832
34MP0003252_abnormal_bile_duct1.41772046
35MP0005365_abnormal_bile_salt1.40276657
36MP0008775_abnormal_heart_ventricle1.39755388
37MP0004215_abnormal_myocardial_fiber1.39461559
38MP0000767_abnormal_smooth_muscle1.38588260
39MP0005360_urolithiasis1.37127845
40MP0004233_abnormal_muscle_weight1.37026705
41MP0002269_muscular_atrophy1.36084615
42MP0005508_abnormal_skeleton_morphology1.36078405
43MP0003806_abnormal_nucleotide_metabolis1.33285541
44MP0003385_abnormal_body_wall1.31072156
45MP0005670_abnormal_white_adipose1.30128278
46MP0004185_abnormal_adipocyte_glucose1.26888909
47MP0001299_abnormal_eye_distance/1.26150505
48MP0005666_abnormal_adipose_tissue1.25427304
49MP0001544_abnormal_cardiovascular_syste1.25368319
50MP0005385_cardiovascular_system_phenoty1.25368319
51MP0005171_absent_coat_pigmentation1.22155313
52MP0003950_abnormal_plasma_membrane1.20313089
53MP0002060_abnormal_skin_morphology1.19496388
54MP0003091_abnormal_cell_migration1.19112405
55MP0004858_abnormal_nervous_system1.18899870
56MP0001661_extended_life_span1.18428611
57MP0002972_abnormal_cardiac_muscle1.16470494
58MP0004130_abnormal_muscle_cell1.14669916
59MP0002249_abnormal_larynx_morphology1.14384954
60MP0003567_abnormal_fetal_cardiomyocyte1.14076642
61MP0002295_abnormal_pulmonary_circulatio1.13424241
62MP0000759_abnormal_skeletal_muscle1.13085581
63MP0003941_abnormal_skin_development1.12804950
64MP0000462_abnormal_digestive_system1.10657523
65MP0005257_abnormal_intraocular_pressure1.10608205
66MP0003115_abnormal_respiratory_system1.10596454
67MP0003283_abnormal_digestive_organ1.09590289
68MP0005083_abnormal_biliary_tract1.07233660
69MP0005369_muscle_phenotype1.06464788
70MP0002128_abnormal_blood_circulation1.06458657
71MP0000534_abnormal_ureter_morphology1.05525344
72MP0003646_muscle_fatigue1.05444663
73MP0003828_pulmonary_edema1.05323965
74MP0005620_abnormal_muscle_contractility1.05312106
75MP0002106_abnormal_muscle_physiology1.04538537
76MP0010386_abnormal_urinary_bladder1.03171885
77MP0001243_abnormal_dermal_layer1.00573222
78MP0002168_other_aberrant_phenotype1.00400848
79MP0005076_abnormal_cell_differentiation1.00244929
80MP0003137_abnormal_impulse_conducting1.00166849
81MP0009250_abnormal_appendicular_skeleto0.99434141
82MP0006054_spinal_hemorrhage0.99093257
83MP0003942_abnormal_urinary_system0.98041924
84MP0000266_abnormal_heart_morphology0.97599913
85MP0003045_fibrosis0.97276234
86MP0000537_abnormal_urethra_morphology0.97169814
87MP0005375_adipose_tissue_phenotype0.96672342
88MP0002925_abnormal_cardiovascular_devel0.96214504
89MP0003935_abnormal_craniofacial_develop0.96160681
90MP0002896_abnormal_bone_mineralization0.95291521
91MP0000428_abnormal_craniofacial_morphol0.95193206
92MP0001348_abnormal_lacrimal_gland0.93026948
93MP0010329_abnormal_lipoprotein_level0.91488430
94MP0002877_abnormal_melanocyte_morpholog0.91135289
95MP0002282_abnormal_trachea_morphology0.91092324
96MP0004197_abnormal_fetal_growth/weight/0.90940480
97MP0001614_abnormal_blood_vessel0.88921179
98MP0001879_abnormal_lymphatic_vessel0.88885253
99MP0000163_abnormal_cartilage_morphology0.87525668
100MP0002933_joint_inflammation0.87437497
101MP0009840_abnormal_foam_cell0.86837440
102MP0001849_ear_inflammation0.86807015
103MP0000747_muscle_weakness0.85781337
104MP0005390_skeleton_phenotype0.85155764
105MP0002932_abnormal_joint_morphology0.84495599
106MP0002127_abnormal_cardiovascular_syste0.83756559
107MP0005165_increased_susceptibility_to0.82692208
108MP0000049_abnormal_middle_ear0.82412864
109MP0005164_abnormal_response_to0.82009997
110MP0004145_abnormal_muscle_electrophysio0.81098594
111MP0000003_abnormal_adipose_tissue0.80650286
112MP0008875_abnormal_xenobiotic_pharmacok0.80482306
113MP0002088_abnormal_embryonic_growth/wei0.80289381
114MP0003984_embryonic_growth_retardation0.79939476
115MP0005248_abnormal_Harderian_gland0.79882836
116MP0000762_abnormal_tongue_morphology0.79551177
117MP0003755_abnormal_palate_morphology0.77930055
118MP0000516_abnormal_urinary_system0.75729273
119MP0002115_abnormal_skeleton_extremities0.74331246
120MP0005409_darkened_coat_color0.73303706
121MP0000230_abnormal_systemic_arterial0.70270497
122MP0004510_myositis0.69883326
123MP0004085_abnormal_heartbeat0.68415833
124MP0005388_respiratory_system_phenotype0.66930521
125MP0002133_abnormal_respiratory_system0.66930521
126MP0000538_abnormal_urinary_bladder0.62039252

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.76600436
2Premature rupture of membranes (HP:0001788)5.10477054
3Broad metatarsal (HP:0001783)4.20396487
4Shallow orbits (HP:0000586)4.15331413
5Increased connective tissue (HP:0009025)4.14770859
6Ankle contracture (HP:0006466)4.14750736
7Vascular tortuosity (HP:0004948)4.12286339
8Right ventricular cardiomyopathy (HP:0011663)3.63973056
9Cerebral aneurysm (HP:0004944)3.60912311
10Arterial tortuosity (HP:0005116)3.58450113
11Aortic dissection (HP:0002647)3.34712794
12Type 1 muscle fiber predominance (HP:0003803)3.11403700
13Aortic regurgitation (HP:0001659)3.07717363
14Muscle fiber splitting (HP:0003555)3.06589456
15Ventricular tachycardia (HP:0004756)3.05927469
16Hyporeflexia of lower limbs (HP:0002600)3.02087721
17Sudden death (HP:0001699)2.98869041
18Vertebral compression fractures (HP:0002953)2.95260262
19Deep venous thrombosis (HP:0002625)2.95188599
20Atrophic scars (HP:0001075)2.89658068
21Peritonitis (HP:0002586)2.87767303
22Aortic aneurysm (HP:0004942)2.81576905
23Spinal rigidity (HP:0003306)2.78130236
24Slender build (HP:0001533)2.76720230
25Mitral valve prolapse (HP:0001634)2.71894205
26Aneurysm (HP:0002617)2.67664925
27Bladder diverticulum (HP:0000015)2.67540567
28Mildly elevated creatine phosphokinase (HP:0008180)2.62624811
29Increased variability in muscle fiber diameter (HP:0003557)2.58990688
30Lymphangioma (HP:0100764)2.57508985
31Fragile skin (HP:0001030)2.55986870
32Blue sclerae (HP:0000592)2.55126548
33Joint laxity (HP:0001388)2.54588003
34Ulnar bowing (HP:0003031)2.52354315
35Wrist flexion contracture (HP:0001239)2.50711033
36Soft skin (HP:0000977)2.50650203
37Lipoatrophy (HP:0100578)2.46527050
38Overgrowth (HP:0001548)2.45950332
39Mitral regurgitation (HP:0001653)2.42228124
40Difficulty climbing stairs (HP:0003551)2.40945438
41Cervical subluxation (HP:0003308)2.38860685
42Aortic valve stenosis (HP:0001650)2.35866538
43Atrial fibrillation (HP:0005110)2.32487056
44Natal tooth (HP:0000695)2.32256743
45Joint stiffness (HP:0001387)2.31149706
46Spondylolisthesis (HP:0003302)2.31123183
47Hypoplastic ischia (HP:0003175)2.28253097
48Exercise-induced muscle cramps (HP:0003710)2.27490926
49Genu recurvatum (HP:0002816)2.26658493
50Hypoventilation (HP:0002791)2.26567505
51Abnormality of skeletal muscle fiber size (HP:0012084)2.22998101
52Abnormality of the calf musculature (HP:0001430)2.21898580
53Dilatation of the ascending aorta (HP:0005111)2.19585565
54Pulmonary artery stenosis (HP:0004415)2.19300687
55Hypoalphalipoproteinemia (HP:0003233)2.16944903
56Turricephaly (HP:0000262)2.16941794
57Difficulty running (HP:0009046)2.16002723
58Abnormality of the 4th metacarpal (HP:0010012)2.12426091
59Coronal craniosynostosis (HP:0004440)2.11776949
60Primary atrial arrhythmia (HP:0001692)2.11219002
61Persistence of primary teeth (HP:0006335)2.10916508
62Wide anterior fontanel (HP:0000260)2.09601304
63Follicular hyperkeratosis (HP:0007502)2.09417132
64Mitral stenosis (HP:0001718)2.06740018
65Supraventricular arrhythmia (HP:0005115)2.04229567
66Abnormality of the ischium (HP:0003174)2.03376970
67Wormian bones (HP:0002645)2.01336511
68Xanthomatosis (HP:0000991)1.99473731
69Abnormal delivery (HP:0001787)1.97878805
70Camptodactyly of toe (HP:0001836)1.97635757
71Bradycardia (HP:0001662)1.97363389
72Broad ribs (HP:0000885)1.97147368
73Supraventricular tachycardia (HP:0004755)1.96946183
74Skin nodule (HP:0200036)1.96264570
75Scapular winging (HP:0003691)1.94952699
76Bundle branch block (HP:0011710)1.94716434
77Short nail (HP:0001799)1.93716136
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92912413
79Short 4th metacarpal (HP:0010044)1.92912413
80Neonatal short-limb short stature (HP:0008921)1.92849838
81Hypoplasia of the iris (HP:0007676)1.92408467
82Hyperextensible skin (HP:0000974)1.92220882
83Upper limb amyotrophy (HP:0009129)1.92202205
84Distal upper limb amyotrophy (HP:0007149)1.92202205
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92072570
86Abnormal cartilage morphology (HP:0002763)1.91847471
87Abnormality of dentin (HP:0010299)1.91027503
88Delayed closure of the anterior fontanelle (HP:0001476)1.90376274
89Mesangial abnormality (HP:0001966)1.89849440
90Delayed cranial suture closure (HP:0000270)1.89296654
91Ectopia lentis (HP:0001083)1.87686567
92Rectal prolapse (HP:0002035)1.86972376
93Striae distensae (HP:0001065)1.86866597
94Limited hip movement (HP:0008800)1.86668309
95Flat cornea (HP:0007720)1.86608638
96Intrahepatic cholestasis (HP:0001406)1.85653054
97Disproportionate tall stature (HP:0001519)1.85112337
98Hip contracture (HP:0003273)1.85049421
99Distal lower limb amyotrophy (HP:0008944)1.84706954
100Hyperacusis (HP:0010780)1.84160085
101Bowing of the arm (HP:0006488)1.83325260
102Bowed forearm bones (HP:0003956)1.83325260
103Knee flexion contracture (HP:0006380)1.83236062
104Round ear (HP:0100830)1.83090979
105Alopecia of scalp (HP:0002293)1.80624252
106Atrioventricular block (HP:0001678)1.80248318
107Elbow flexion contracture (HP:0002987)1.80216653
108Myoglobinuria (HP:0002913)1.78672849
109Asymmetric septal hypertrophy (HP:0001670)1.78465475
110Biconcave vertebral bodies (HP:0004586)1.77785439
111EMG: myopathic abnormalities (HP:0003458)1.77260903
112Mesomelia (HP:0003027)1.76965621
113Infantile muscular hypotonia (HP:0008947)1.76764745
114Generalized amyotrophy (HP:0003700)1.76139384
115Abnormality of the Achilles tendon (HP:0005109)1.75672347
116Dilated cardiomyopathy (HP:0001644)1.74110729
117Osteolytic defects of the hand bones (HP:0009699)1.71969722
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.71969722
119Asymmetry of the thorax (HP:0001555)1.71194932
120Subaortic stenosis (HP:0001682)1.70861145
121Abnormality of the left ventricular outflow tract (HP:0011103)1.70861145
122Abnormality of the acetabulum (HP:0003170)1.69761666
123Distal lower limb muscle weakness (HP:0009053)1.69728845
124Abnormal atrioventricular conduction (HP:0005150)1.69658518
125Protruding ear (HP:0000411)1.69412812
126Ulnar deviation of the wrist (HP:0003049)1.68927379
127Achilles tendon contracture (HP:0001771)1.68307196
128Bell-shaped thorax (HP:0001591)1.68283572
129Joint contractures involving the joints of the feet (HP:0100492)1.68013818
130Flexion contracture of toe (HP:0005830)1.68013818
131Limb-girdle muscle weakness (HP:0003325)1.67550535
132Long toe (HP:0010511)1.67193372
133Bowel diverticulosis (HP:0005222)1.66203263
134Radial bowing (HP:0002986)1.66142930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.32965380
2TRIB33.84936223
3LATS13.39890235
4PKN23.00321799
5PDGFRA2.79953338
6DDR22.73755480
7SIK12.70045311
8RIPK12.66692954
9CDK122.59399524
10LATS22.35340146
11ERN12.01804335
12LIMK11.94108252
13DMPK1.87608899
14EPHB21.84071022
15EPHA21.82041178
16MYLK1.74627589
17STK38L1.57872604
18BCKDK1.56108153
19TESK11.53201172
20PTK61.52156696
21ICK1.50612572
22NTRK11.49864792
23EEF2K1.48110784
24TGFBR21.47952471
25LMTK21.47892685
26MUSK1.45128105
27BMX1.44729295
28PAK21.42889815
29CAMK1D1.40825958
30NEK11.40488240
31PAK41.39931577
32MTOR1.38803187
33PTK21.32905114
34MET1.31710550
35MAP3K61.27430874
36TIE11.25396790
37RPS6KA21.22175623
38FER1.21425716
39STK31.16000550
40PDK31.13180707
41PDK41.13180707
42MAP3K101.11888214
43SMG11.08927571
44FLT31.07682149
45PAK31.02923040
46FGFR41.02224403
47MAPK71.01744792
48ABL20.97686821
49CDK60.95630615
50MELK0.95049760
51FGFR10.93640510
52PDGFRB0.91936573
53PHKG10.90127957
54PHKG20.90127957
55PIK3CA0.84543579
56ADRBK10.83954277
57EPHB10.83071874
58CAMK1G0.82726384
59FGFR20.82383880
60PRKD10.81897907
61ROCK10.81718280
62TRPM70.81717622
63STK380.81089066
64LRRK20.80477118
65KIT0.80470210
66PDK20.79417708
67CDC42BPA0.77380941
68ILK0.76327697
69MAPKAPK30.76321470
70WNK10.74807913
71CDK80.73650664
72TYRO30.72946787
73RPS6KA60.71142065
74EPHA30.70556580
75NEK90.68892886
76MAP2K30.67165174
77OBSCN0.66042741
78TTK0.64329236
79PRKAA20.63917851
80RPS6KB20.63668092
81MARK20.63335431
82MAP3K30.62890195
83MAP3K70.62050851
84CDK40.60489082
85GRK50.60381916
86HIPK20.60297118
87MOS0.58313261
88KDR0.57888561
89CDK70.57499064
90MAPK40.55589821
91CAMK2D0.54133316
92PTK2B0.53922963
93AKT20.52763568
94CAMK2G0.52403774
95DYRK1B0.50730528
96MAPK120.50409293
97CAMK40.50339940
98GSK3A0.50284445
99STK40.49545892
100ROCK20.49528864
101PRKAA10.48397323
102PRKD20.46900020
103TGFBR10.45559047
104AKT30.45504649
105DAPK30.44980549
106MST1R0.44757613
107CAMK10.44648737
108MAP2K10.43867247
109GRK70.43273531
110STK100.43258037
111ERBB40.42645256
112MAPKAPK50.41757716
113PDPK10.41742259
114PRPF4B0.41400667
115CLK10.40767752
116MAPK10.38832286
117MAPKAPK20.38615834
118RPS6KL10.36473394
119RPS6KC10.36473394
120INSR0.35433479
121PAK10.35257681
122MAP3K80.35136439
123MAPK110.35065749
124GRK10.34930240
125NEK20.34232972
126PRKG20.33355565
127PIK3CG0.33259626
128PAK60.32887770
129CDK90.32874932
130RET0.30960416
131RPS6KA40.30584006

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88273289
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76068987
3Fatty acid degradation_Homo sapiens_hsa000712.60309857
4Nitrogen metabolism_Homo sapiens_hsa009102.56071731
5ECM-receptor interaction_Homo sapiens_hsa045122.48342584
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22333350
7Arginine biosynthesis_Homo sapiens_hsa002202.18644537
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16789247
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11371812
10Fatty acid metabolism_Homo sapiens_hsa012122.08034399
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.07330541
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04770223
13Dilated cardiomyopathy_Homo sapiens_hsa054142.03392719
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.01500474
15Propanoate metabolism_Homo sapiens_hsa006402.00973506
16Tryptophan metabolism_Homo sapiens_hsa003801.98662776
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.96935266
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94836062
19Complement and coagulation cascades_Homo sapiens_hsa046101.93626112
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.90114447
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89837895
22PPAR signaling pathway_Homo sapiens_hsa033201.89710083
23Focal adhesion_Homo sapiens_hsa045101.82185844
24Lysine degradation_Homo sapiens_hsa003101.73818447
25Adherens junction_Homo sapiens_hsa045201.61468717
26Carbon metabolism_Homo sapiens_hsa012001.55739524
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.49527002
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41887023
29Fatty acid biosynthesis_Homo sapiens_hsa000611.35300046
30Biosynthesis of amino acids_Homo sapiens_hsa012301.34924096
31Proteoglycans in cancer_Homo sapiens_hsa052051.31833515
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30451057
33Basal cell carcinoma_Homo sapiens_hsa052171.27121518
34Pyruvate metabolism_Homo sapiens_hsa006201.24104851
35Hippo signaling pathway_Homo sapiens_hsa043901.22838873
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22638967
37Amoebiasis_Homo sapiens_hsa051461.18688243
38Chemical carcinogenesis_Homo sapiens_hsa052041.16405617
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16355111
40Bile secretion_Homo sapiens_hsa049761.16248524
41Butanoate metabolism_Homo sapiens_hsa006501.15099121
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14942899
43Small cell lung cancer_Homo sapiens_hsa052221.14885097
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12763929
45Prion diseases_Homo sapiens_hsa050201.11070329
46TGF-beta signaling pathway_Homo sapiens_hsa043501.09864993
47Starch and sucrose metabolism_Homo sapiens_hsa005001.09589020
48Selenocompound metabolism_Homo sapiens_hsa004501.08304157
49Protein digestion and absorption_Homo sapiens_hsa049741.07956183
50Caffeine metabolism_Homo sapiens_hsa002321.07664902
51Arginine and proline metabolism_Homo sapiens_hsa003301.03521231
52beta-Alanine metabolism_Homo sapiens_hsa004101.03168547
53Gap junction_Homo sapiens_hsa045401.02458685
54Bladder cancer_Homo sapiens_hsa052191.01751999
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.00326817
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00014860
57Melanogenesis_Homo sapiens_hsa049160.99428693
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97865958
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96221009
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95199280
61Renin secretion_Homo sapiens_hsa049240.94775333
62Insulin resistance_Homo sapiens_hsa049310.93307879
63Tight junction_Homo sapiens_hsa045300.93210867
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.92910784
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90358785
66Viral myocarditis_Homo sapiens_hsa054160.89715626
67Hedgehog signaling pathway_Homo sapiens_hsa043400.88363327
68One carbon pool by folate_Homo sapiens_hsa006700.88305086
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.86463450
70MicroRNAs in cancer_Homo sapiens_hsa052060.86424106
71Phenylalanine metabolism_Homo sapiens_hsa003600.86333746
72Peroxisome_Homo sapiens_hsa041460.85340664
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83176761
74Malaria_Homo sapiens_hsa051440.81493366
75AMPK signaling pathway_Homo sapiens_hsa041520.80446382
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78339540
77Notch signaling pathway_Homo sapiens_hsa043300.78273814
78Axon guidance_Homo sapiens_hsa043600.78179936
79Oxytocin signaling pathway_Homo sapiens_hsa049210.76771471
80Fat digestion and absorption_Homo sapiens_hsa049750.76593812
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.75885703
82Staphylococcus aureus infection_Homo sapiens_hsa051500.75475302
83Retinol metabolism_Homo sapiens_hsa008300.75418402
84Platelet activation_Homo sapiens_hsa046110.75107033
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74777362
86Other glycan degradation_Homo sapiens_hsa005110.73686052
87Tyrosine metabolism_Homo sapiens_hsa003500.73089625
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72015392
89GnRH signaling pathway_Homo sapiens_hsa049120.69576880
90Glioma_Homo sapiens_hsa052140.69299273
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68158659
92Sulfur relay system_Homo sapiens_hsa041220.67771529
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66438116
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66099110
95Renal cell carcinoma_Homo sapiens_hsa052110.65803666
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.64495468
97Calcium signaling pathway_Homo sapiens_hsa040200.64380199
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64319773
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63409388
100Melanoma_Homo sapiens_hsa052180.63182910
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61773937
102Estrogen signaling pathway_Homo sapiens_hsa049150.61659334
103Glucagon signaling pathway_Homo sapiens_hsa049220.59490164
104cAMP signaling pathway_Homo sapiens_hsa040240.57497413
105mTOR signaling pathway_Homo sapiens_hsa041500.57478863
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56336974
107Insulin signaling pathway_Homo sapiens_hsa049100.54184187
108Histidine metabolism_Homo sapiens_hsa003400.53898300
109Ovarian steroidogenesis_Homo sapiens_hsa049130.53332238
110Thyroid hormone synthesis_Homo sapiens_hsa049180.52974368
111Pathways in cancer_Homo sapiens_hsa052000.51456003
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51054742
113Pancreatic cancer_Homo sapiens_hsa052120.50995319
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.49578571
115Gastric acid secretion_Homo sapiens_hsa049710.48984650
116Renin-angiotensin system_Homo sapiens_hsa046140.48694990
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48389208
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47604455
119Dorso-ventral axis formation_Homo sapiens_hsa043200.47073881
120Circadian rhythm_Homo sapiens_hsa047100.46855192
121Ras signaling pathway_Homo sapiens_hsa040140.45710907
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45483461
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44689166
124MAPK signaling pathway_Homo sapiens_hsa040100.44348496
125ABC transporters_Homo sapiens_hsa020100.44288105
126Chronic myeloid leukemia_Homo sapiens_hsa052200.44169031
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43351000
128Fatty acid elongation_Homo sapiens_hsa000620.43151447
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43125172
130Glycerolipid metabolism_Homo sapiens_hsa005610.42653297
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.41279768
132Cardiac muscle contraction_Homo sapiens_hsa042600.39841393
133Salivary secretion_Homo sapiens_hsa049700.39655771
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.38046573
135Rap1 signaling pathway_Homo sapiens_hsa040150.37925353
136HTLV-I infection_Homo sapiens_hsa051660.37919818
137Galactose metabolism_Homo sapiens_hsa000520.37592991
138Insulin secretion_Homo sapiens_hsa049110.36166725
139HIF-1 signaling pathway_Homo sapiens_hsa040660.35990899
140Endometrial cancer_Homo sapiens_hsa052130.33988746
141Wnt signaling pathway_Homo sapiens_hsa043100.33304373
142Prostate cancer_Homo sapiens_hsa052150.33106297
143Fructose and mannose metabolism_Homo sapiens_hsa000510.31147145

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