KAAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
14-hydroxyproline metabolic process (GO:0019471)6.35131651
2peptidyl-proline hydroxylation (GO:0019511)5.41978302
3protein hydroxylation (GO:0018126)5.18872534
4intestinal cholesterol absorption (GO:0030299)5.13441013
5toxin transport (GO:1901998)4.73788666
6negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.64834625
7artery smooth muscle contraction (GO:0014824)4.61450744
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.38439954
9L-phenylalanine metabolic process (GO:0006558)4.38439954
10regulation of mesenchymal cell apoptotic process (GO:2001053)4.31637700
11labyrinthine layer development (GO:0060711)4.12210646
12xenobiotic catabolic process (GO:0042178)4.08513138
13tonic smooth muscle contraction (GO:0014820)4.01638936
14heart trabecula formation (GO:0060347)3.91655439
15succinate metabolic process (GO:0006105)3.82386399
16L-alpha-amino acid transmembrane transport (GO:1902475)3.67714515
17high-density lipoprotein particle remodeling (GO:0034375)3.67479294
18nephron tubule formation (GO:0072079)3.67298738
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.66792718
20positive regulation of digestive system process (GO:0060456)3.53856206
21positive regulation of hormone metabolic process (GO:0032352)3.53659988
22daunorubicin metabolic process (GO:0044597)3.53184438
23polyketide metabolic process (GO:0030638)3.53184438
24doxorubicin metabolic process (GO:0044598)3.53184438
25drug transmembrane transport (GO:0006855)3.50356984
26purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.50114874
273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.50114874
28nephron epithelium morphogenesis (GO:0072088)3.48417625
29nephron tubule morphogenesis (GO:0072078)3.48417625
30L-phenylalanine catabolic process (GO:0006559)3.42816687
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42816687
32reverse cholesterol transport (GO:0043691)3.42240482
33cholesterol efflux (GO:0033344)3.40325187
34response to nitric oxide (GO:0071731)3.35145237
35plasma lipoprotein particle remodeling (GO:0034369)3.32647743
36protein-lipid complex remodeling (GO:0034368)3.32647743
37macromolecular complex remodeling (GO:0034367)3.32647743
38peptidyl-arginine omega-N-methylation (GO:0035247)3.25329376
39GDP-mannose metabolic process (GO:0019673)3.24685895
40pharyngeal system development (GO:0060037)3.16657426
41ventricular septum morphogenesis (GO:0060412)3.15787093
42aminoglycoside antibiotic metabolic process (GO:0030647)3.13250479
43very-low-density lipoprotein particle assembly (GO:0034379)3.11480871
44low-density lipoprotein particle remodeling (GO:0034374)3.10951780
45plasma lipoprotein particle clearance (GO:0034381)3.09459785
46phasic smooth muscle contraction (GO:0014821)3.07369072
47carnitine transmembrane transport (GO:1902603)3.04737897
48digestion (GO:0007586)3.03580370
49regulation of cholesterol esterification (GO:0010872)3.01941147
50protein carboxylation (GO:0018214)3.00803509
51peptidyl-glutamic acid carboxylation (GO:0017187)3.00803509
52carnitine transport (GO:0015879)3.00601374
53amino-acid betaine transport (GO:0015838)3.00601374
54ribosomal small subunit assembly (GO:0000028)2.99773926
55tricarboxylic acid cycle (GO:0006099)2.97326965
56lung epithelium development (GO:0060428)2.97115478
57organic cation transport (GO:0015695)2.90427814
58negative regulation of epidermal cell differentiation (GO:0045605)2.88358634
59plasma lipoprotein particle assembly (GO:0034377)2.87577356
60negative regulation of activin receptor signaling pathway (GO:0032926)2.86159787
61vascular smooth muscle contraction (GO:0014829)2.86126762
62cellular zinc ion homeostasis (GO:0006882)2.84951407
63cholesterol transport (GO:0030301)2.78114935
64sterol transport (GO:0015918)2.78114935
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76860661
66branching involved in salivary gland morphogenesis (GO:0060445)2.76805555
67low-density lipoprotein particle clearance (GO:0034383)2.75088924
68regulation of bile acid biosynthetic process (GO:0070857)2.74957615
69regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.73939787
70positive regulation of mitochondrial fission (GO:0090141)2.71242185
71macroautophagy (GO:0016236)2.70297569
72plasma lipoprotein particle organization (GO:0071827)2.70083834
73proteasome assembly (GO:0043248)2.68698238
74nucleoside bisphosphate metabolic process (GO:0033865)2.68396591
75purine nucleoside bisphosphate metabolic process (GO:0034032)2.68396591
76ribonucleoside bisphosphate metabolic process (GO:0033875)2.68396591
77regulation of apoptotic cell clearance (GO:2000425)2.67964747
78heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.67722416
79coenzyme catabolic process (GO:0009109)2.67665948
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.67167575
81negative regulation of sterol transport (GO:0032372)2.67028353
82negative regulation of cholesterol transport (GO:0032375)2.67028353
83mannosylation (GO:0097502)2.66685819
84quaternary ammonium group transport (GO:0015697)2.66595288
85negative regulation of epidermis development (GO:0045683)2.64849801
86intestinal absorption (GO:0050892)2.63124236
87calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.63015235
88regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.62493065
89positive regulation of hormone biosynthetic process (GO:0046886)2.60989579
90cardiac septum morphogenesis (GO:0060411)2.60945804
91rRNA transcription (GO:0009303)2.59974801
92positive regulation of smoothened signaling pathway (GO:0045880)2.59641658
93positive regulation of megakaryocyte differentiation (GO:0045654)2.55692159
94regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)2.55075809
95drug transport (GO:0015893)2.54777539
96regulation of heterotypic cell-cell adhesion (GO:0034114)2.54729698
97establishment of planar polarity (GO:0001736)2.53904493
98establishment of tissue polarity (GO:0007164)2.53904493
99peristalsis (GO:0030432)2.53006265
100energy homeostasis (GO:0097009)2.52668537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.18413148
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.04059133
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.84792066
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.95854846
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.92942333
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23667093
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.19346402
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.14806918
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.94729578
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67465177
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.61328789
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.50821743
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.50434949
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30904609
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.24450784
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16445582
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.16389498
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.02528976
19GATA6_25053715_ChIP-Seq_YYC3_Human1.91189869
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90077738
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84492406
22ZNF263_19887448_ChIP-Seq_K562_Human1.82185866
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81546657
24SOX2_20726797_ChIP-Seq_SW620_Human1.73871231
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72955399
26GATA3_24758297_ChIP-Seq_MCF-7_Human1.66912549
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66820039
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65963638
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64221072
30GATA4_25053715_ChIP-Seq_YYC3_Human1.62246746
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.60762770
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56356668
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55886466
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55671072
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.52283420
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50565050
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.47517068
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.43779710
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42717880
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40098000
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39487706
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38080838
43ELF5_23300383_ChIP-Seq_T47D_Human1.37735452
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36960957
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36106699
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.34657218
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33774699
48GABP_19822575_ChIP-Seq_HepG2_Human1.32069491
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31479897
50DCP1A_22483619_ChIP-Seq_HELA_Human1.27944616
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26682528
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24254193
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23245072
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22518610
55TP53_22127205_ChIP-Seq_IMR90_Human1.21578417
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.17868919
57ATF3_27146783_Chip-Seq_COLON_Human1.17545244
58KDM5A_27292631_Chip-Seq_BREAST_Human1.16457464
59XRN2_22483619_ChIP-Seq_HELA_Human1.16129777
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15237983
61TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14691445
62FOXP3_21729870_ChIP-Seq_TREG_Human1.13948111
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.09609972
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08958776
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07543981
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07329200
67AHR_22903824_ChIP-Seq_MCF-7_Human1.06970887
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05615252
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.04681550
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00846428
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00702535
72MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99994704
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96715992
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95221537
75BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95195500
76GBX2_23144817_ChIP-Seq_PC3_Human0.93072556
77CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92781504
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92573502
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91416683
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90649382
81MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88633594
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88521039
83TRIM28_21343339_ChIP-Seq_HEK293_Human0.88189264
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.87601409
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87601409
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.86914282
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85947498
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.85242318
89* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85171895
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84820109
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.84160657
92TTF2_22483619_ChIP-Seq_HELA_Human0.81991307
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81736637
94* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81638564
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81542896
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81493427
97CJUN_26792858_Chip-Seq_BT549_Human0.80320928
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80120446
99EOMES_21245162_ChIP-Seq_HESCs_Human0.79962226
100MYC_18940864_ChIP-ChIP_HL60_Human0.79237830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.46691632
2MP0005083_abnormal_biliary_tract4.12887896
3MP0005365_abnormal_bile_salt3.70914595
4MP0003195_calcinosis3.56631477
5MP0009780_abnormal_chondrocyte_physiolo3.46883112
6MP0005084_abnormal_gallbladder_morpholo3.26896445
7MP0001666_abnormal_nutrient_absorption3.19278506
8MP0002139_abnormal_hepatobiliary_system3.01022253
9MP0009840_abnormal_foam_cell2.89403813
10MP0000569_abnormal_digit_pigmentation2.81114494
11MP0005085_abnormal_gallbladder_physiolo2.77939495
12MP0010386_abnormal_urinary_bladder2.66479413
13MP0003283_abnormal_digestive_organ2.50800583
14MP0000383_abnormal_hair_follicle2.34602563
15MP0002837_dystrophic_cardiac_calcinosis2.29812607
16MP0005408_hypopigmentation2.29491864
17MP0010678_abnormal_skin_adnexa2.19133729
18MP0003252_abnormal_bile_duct2.18954269
19MP0003806_abnormal_nucleotide_metabolis2.12141293
20MP0003122_maternal_imprinting2.02113832
21MP0003868_abnormal_feces_composition1.97213799
22MP0002938_white_spotting1.96688208
23MP0010329_abnormal_lipoprotein_level1.85256840
24MP0000613_abnormal_salivary_gland1.82801725
25MP0003942_abnormal_urinary_system1.77336689
26MP0005379_endocrine/exocrine_gland_phen1.75768753
27MP0002132_abnormal_respiratory_system1.73698506
28MP0005332_abnormal_amino_acid1.72615703
29MP0002254_reproductive_system_inflammat1.69534828
30MP0000462_abnormal_digestive_system1.68143339
31MP0002138_abnormal_hepatobiliary_system1.67561527
32MP0005058_abnormal_lysosome_morphology1.58453812
33MP0001944_abnormal_pancreas_morphology1.54019946
34MP0008875_abnormal_xenobiotic_pharmacok1.52974493
35MP0002160_abnormal_reproductive_system1.44518968
36MP0008995_early_reproductive_senescence1.40112281
37MP0000538_abnormal_urinary_bladder1.35280097
38MP0004264_abnormal_extraembryonic_tissu1.31047093
39MP0005360_urolithiasis1.24192962
40MP0002876_abnormal_thyroid_physiology1.23777570
41MP0005220_abnormal_exocrine_pancreas1.22960850
42MP0000678_abnormal_parathyroid_gland1.22432964
43MP0001756_abnormal_urination1.21209566
44MP0003121_genomic_imprinting1.18070070
45MP0003941_abnormal_skin_development1.16975467
46MP0002234_abnormal_pharynx_morphology1.15602026
47MP0002282_abnormal_trachea_morphology1.10454944
48MP0000534_abnormal_ureter_morphology1.08419142
49MP0000639_abnormal_adrenal_gland1.08068759
50MP0002928_abnormal_bile_duct1.06012114
51MP0003123_paternal_imprinting1.05014658
52MP0009053_abnormal_anal_canal1.00133648
53MP0004019_abnormal_vitamin_homeostasis0.96649842
54MP0008961_abnormal_basal_metabolism0.94166288
55MP0000013_abnormal_adipose_tissue0.93824502
56MP0002909_abnormal_adrenal_gland0.91676547
57MP0003950_abnormal_plasma_membrane0.91562860
58MP0005636_abnormal_mineral_homeostasis0.89541864
59MP0002089_abnormal_postnatal_growth/wei0.87961304
60MP0003755_abnormal_palate_morphology0.87234207
61MP0002118_abnormal_lipid_homeostasis0.85160306
62MP0004233_abnormal_muscle_weight0.84527097
63MP0009046_muscle_twitch0.84347657
64MP0004272_abnormal_basement_membrane0.83301108
65MP0004484_altered_response_of0.81461503
66MP0010234_abnormal_vibrissa_follicle0.79372599
67MP0000681_abnormal_thyroid_gland0.78915945
68MP0008007_abnormal_cellular_replicative0.77413705
69MP0003718_maternal_effect0.77352074
70MP0001661_extended_life_span0.75065247
71MP0000598_abnormal_liver_morphology0.74018727
72MP0001873_stomach_inflammation0.73858005
73MP0005187_abnormal_penis_morphology0.73152204
74MP0002078_abnormal_glucose_homeostasis0.72319420
75MP0002751_abnormal_autonomic_nervous0.72279910
76MP0000371_diluted_coat_color0.71553875
77MP0005646_abnormal_pituitary_gland0.70032852
78MP0005389_reproductive_system_phenotype0.69407989
79MP0004134_abnormal_chest_morphology0.69115993
80MP0005330_cardiomyopathy0.68853543
81MP0003943_abnormal_hepatobiliary_system0.66565826
82MP0003115_abnormal_respiratory_system0.66284135
83MP0003786_premature_aging0.66078669
84MP0003953_abnormal_hormone_level0.66037124
85MP0000003_abnormal_adipose_tissue0.65880556
86MP0003959_abnormal_lean_body0.65785955
87MP0000049_abnormal_middle_ear0.64165613
88MP0000631_abnormal_neuroendocrine_gland0.63836333
89MP0006035_abnormal_mitochondrial_morpho0.63219252
90MP0009643_abnormal_urine_homeostasis0.62913653
91MP0005448_abnormal_energy_balance0.62801626
92MP0001145_abnormal_male_reproductive0.62479495
93MP0005174_abnormal_tail_pigmentation0.62090414
94MP0003315_abnormal_perineum_morphology0.61995567
95MP0005670_abnormal_white_adipose0.61183793
96MP0000467_abnormal_esophagus_morphology0.60920327
97MP0000609_abnormal_liver_physiology0.60438950
98MP0003567_abnormal_fetal_cardiomyocyte0.59438632
99MP0000920_abnormal_myelination0.56896975
100MP0002163_abnormal_gland_morphology0.56631700

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.82204117
2Methylmalonic aciduria (HP:0012120)4.55904569
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.42962322
4Humeroradial synostosis (HP:0003041)3.74601127
5Synostosis involving the elbow (HP:0003938)3.74601127
6Prolonged partial thromboplastin time (HP:0003645)3.65107103
7Cerebellar dysplasia (HP:0007033)3.59175287
8Vascular calcification (HP:0004934)3.38161023
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33485869
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.24716399
11Short 1st metacarpal (HP:0010034)3.24716399
12Deep venous thrombosis (HP:0002625)3.13950143
13Onycholysis (HP:0001806)2.98601198
14Abnormality of the 1st metacarpal (HP:0010009)2.98490018
15Cardiovascular calcification (HP:0011915)2.89558785
16Steatorrhea (HP:0002570)2.86142791
17Hypobetalipoproteinemia (HP:0003563)2.85544241
18Loss of speech (HP:0002371)2.82267273
19Reduced antithrombin III activity (HP:0001976)2.81088219
20Abnormality of the pons (HP:0007361)2.68996857
21Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.67069031
22Vertebral hypoplasia (HP:0008417)2.67069031
23Type I transferrin isoform profile (HP:0003642)2.64954770
24Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63924721
25Dicarboxylic aciduria (HP:0003215)2.63924721
26Abnormality of urine glucose concentration (HP:0011016)2.63687225
27Glycosuria (HP:0003076)2.63687225
28Fat malabsorption (HP:0002630)2.62590332
29Amblyopia (HP:0000646)2.60567953
30Microretrognathia (HP:0000308)2.59804066
31Hypoplasia of the pons (HP:0012110)2.59645180
32Confusion (HP:0001289)2.53333751
33Abnormal glycosylation (HP:0012345)2.51933051
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51933051
35Abnormal protein N-linked glycosylation (HP:0012347)2.51933051
36Abnormal protein glycosylation (HP:0012346)2.51933051
37Cortical visual impairment (HP:0100704)2.51133250
38Enlarged kidneys (HP:0000105)2.43944637
39Right ventricular cardiomyopathy (HP:0011663)2.43790502
40Abnormality of glycolysis (HP:0004366)2.43375268
41Vacuolated lymphocytes (HP:0001922)2.41592058
42Mucopolysacchariduria (HP:0008155)2.39702148
43Urinary glycosaminoglycan excretion (HP:0003541)2.39702148
44Potter facies (HP:0002009)2.39553565
45Facial shape deformation (HP:0011334)2.39553565
46Xanthomatosis (HP:0000991)2.36739849
47Hyperammonemia (HP:0001987)2.35242108
48Hypomagnesemia (HP:0002917)2.29979412
49Hyperglycinemia (HP:0002154)2.26860445
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26408055
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26408055
52Abnormality of polysaccharide metabolism (HP:0011012)2.26408055
53Respiratory failure (HP:0002878)2.25384494
54Increased serum pyruvate (HP:0003542)2.24097997
55Epidermoid cyst (HP:0200040)2.15599006
56Polycythemia (HP:0001901)2.15456563
57Abnormality of fatty-acid metabolism (HP:0004359)2.12056762
58Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.11404729
59Hypoplasia of the uterus (HP:0000013)2.09806345
60Joint hemorrhage (HP:0005261)2.06106162
61Short phalanx of the thumb (HP:0009660)2.02283450
62Acute encephalopathy (HP:0006846)2.00798976
63Absent eyebrow (HP:0002223)1.99343694
64Abnormal tarsal ossification (HP:0008369)1.98008735
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97996646
66Hypoglycemic coma (HP:0001325)1.97368303
67Unilateral renal agenesis (HP:0000122)1.93343564
68Abnormality of renal resorption (HP:0011038)1.92670385
69Aplasia/hypoplasia of the uterus (HP:0008684)1.92557297
70Abnormality of the middle phalanges of the toes (HP:0010183)1.88868491
71Sex reversal (HP:0012245)1.88027279
72Abnormal sex determination (HP:0012244)1.88027279
73Hepatic necrosis (HP:0002605)1.88016151
74Type II lissencephaly (HP:0007260)1.87154236
75Increased neuronal autofluorescent lipopigment (HP:0002074)1.86955578
76Gonadal dysgenesis (HP:0000133)1.85676385
77Pancreatic cysts (HP:0001737)1.84159299
78Abnormality of renal excretion (HP:0011036)1.83737125
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82988730
80Abnormality of alanine metabolism (HP:0010916)1.82988730
81Hyperalaninemia (HP:0003348)1.82988730
82Abnormality of the renal medulla (HP:0100957)1.81639240
83Respiratory distress (HP:0002098)1.81147071
84Prolonged neonatal jaundice (HP:0006579)1.80315690
85Symphalangism affecting the phalanges of the hand (HP:0009773)1.80059807
86Bicornuate uterus (HP:0000813)1.79229934
87Abnormality of the vitreous humor (HP:0004327)1.79085811
88Occipital encephalocele (HP:0002085)1.77671876
89Facial cleft (HP:0002006)1.77603563
90Increased CSF protein (HP:0002922)1.77176299
91Hypophosphatemia (HP:0002148)1.76807722
92Abnormality of magnesium homeostasis (HP:0004921)1.74985140
93Short hallux (HP:0010109)1.74618335
94Acute necrotizing encephalopathy (HP:0006965)1.73623101
95Abnormal mitochondria in muscle tissue (HP:0008316)1.73120139
96Cystic liver disease (HP:0006706)1.73051373
97Hypolipoproteinemia (HP:0010981)1.73044290
98Broad distal phalanx of finger (HP:0009836)1.71155485
99Cardiomegaly (HP:0001640)1.71101189
100Unsteady gait (HP:0002317)1.68434462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.12107494
2SCYL23.48242819
3TAOK33.00011923
4CDK82.96647061
5PNCK2.83124410
6FGFR42.64358446
7PDK22.48575496
8TAF12.33093898
9EPHA22.25558810
10STK392.25552544
11CASK2.08730152
12TGFBR22.07506045
13FGFR22.04689114
14TSSK61.99803048
15GRK71.94515718
16VRK21.94263454
17GRK11.85468794
18MAP3K121.83106185
19STK38L1.73846165
20MAP3K41.68774622
21ZAK1.55588870
22MUSK1.52724822
23CSNK1G31.50379110
24BCKDK1.47069334
25MAPK71.42122063
26CSNK1A1L1.38486844
27MAP2K31.37439313
28OXSR11.36705561
29NME21.33560208
30FGFR31.31659400
31CSNK1G11.26867133
32RPS6KB21.26498610
33MAP3K31.24489751
34MAP2K61.21389955
35SMG11.19130504
36FRK1.16552180
37MST41.11707544
38WNK41.06934197
39PIK3CA1.05382908
40VRK11.01546942
41FGFR10.99219679
42CSNK1G20.98536286
43LIMK10.97233491
44TLK10.96844825
45TRIB30.94228182
46MAP3K60.94082272
47IRAK30.90590645
48STK160.84389917
49RET0.83221775
50PLK40.74213981
51CHUK0.73750524
52DAPK30.71885249
53MYLK0.68593556
54WEE10.65252454
55PDPK10.64768611
56AKT20.64663127
57MAP2K40.64502868
58RPS6KB10.63022094
59BRSK10.62912297
60PTK20.62344906
61STK40.62304968
62MAPKAPK30.62167045
63SIK10.60615125
64MAPK150.60240422
65NEK60.59639608
66ADRBK10.58704304
67DYRK1B0.55747324
68DAPK10.55439341
69ERBB20.55115842
70PRKCE0.55111898
71CAMK2D0.53663967
72ICK0.52692271
73PLK20.51641966
74ILK0.50763818
75GRK50.49764347
76PRKCI0.49210410
77AKT30.48763432
78CAMK1G0.48593140
79CSNK1D0.47915075
80LRRK20.45601845
81BRSK20.45481136
82NUAK10.45160403
83MAP3K20.44369160
84STK100.43731734
85PIM20.42901488
86PLK30.42867355
87PDK10.40543644
88AURKA0.38465605
89CSNK2A10.37560116
90TRIM280.37403446
91BRD40.37248866
92CSNK2A20.36878586
93CDC42BPA0.36118010
94PRKCG0.34481429
95SGK30.34193114
96MELK0.33316632
97PASK0.32502471
98MAP3K10.29615275
99CSNK1E0.29598288
100FER0.29337673

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.58831220
2Propanoate metabolism_Homo sapiens_hsa006403.08826527
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.04787874
4Fat digestion and absorption_Homo sapiens_hsa049752.53545847
5Sulfur metabolism_Homo sapiens_hsa009202.50072679
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28170018
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27060668
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.09808111
9Oxidative phosphorylation_Homo sapiens_hsa001901.94779714
10Proteasome_Homo sapiens_hsa030501.94580236
11Ribosome_Homo sapiens_hsa030101.86698008
12Folate biosynthesis_Homo sapiens_hsa007901.83219894
13N-Glycan biosynthesis_Homo sapiens_hsa005101.83135644
14Fatty acid elongation_Homo sapiens_hsa000621.83022994
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80502740
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80285964
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78439943
18Galactose metabolism_Homo sapiens_hsa000521.73457757
19Peroxisome_Homo sapiens_hsa041461.71881655
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69215873
21Complement and coagulation cascades_Homo sapiens_hsa046101.63339656
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53087872
23Arginine and proline metabolism_Homo sapiens_hsa003301.46504920
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45929704
25Retinol metabolism_Homo sapiens_hsa008301.41879373
26Vitamin digestion and absorption_Homo sapiens_hsa049771.40202258
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.39715321
28Fructose and mannose metabolism_Homo sapiens_hsa000511.37535610
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.35740978
30Steroid biosynthesis_Homo sapiens_hsa001001.34770525
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34587086
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33164419
33Sphingolipid metabolism_Homo sapiens_hsa006001.31305930
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29458962
35One carbon pool by folate_Homo sapiens_hsa006701.28026439
36Parkinsons disease_Homo sapiens_hsa050121.22962157
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22674175
38Starch and sucrose metabolism_Homo sapiens_hsa005001.19520630
39Carbon metabolism_Homo sapiens_hsa012001.19218412
40Fatty acid degradation_Homo sapiens_hsa000711.18676121
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16859021
42Chemical carcinogenesis_Homo sapiens_hsa052041.14862996
43Other glycan degradation_Homo sapiens_hsa005111.13714914
44Sulfur relay system_Homo sapiens_hsa041221.13464277
45Arginine biosynthesis_Homo sapiens_hsa002201.12850959
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.10003055
47ABC transporters_Homo sapiens_hsa020101.06965099
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06153631
49Fatty acid metabolism_Homo sapiens_hsa012121.05682760
50Glutathione metabolism_Homo sapiens_hsa004801.04791671
51Pancreatic secretion_Homo sapiens_hsa049721.01852058
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00385310
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97874176
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97621321
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95091868
56Metabolic pathways_Homo sapiens_hsa011000.93979486
57Selenocompound metabolism_Homo sapiens_hsa004500.93404522
58RNA polymerase_Homo sapiens_hsa030200.93163431
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92774013
60Alzheimers disease_Homo sapiens_hsa050100.92669993
61beta-Alanine metabolism_Homo sapiens_hsa004100.90465356
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88245635
63Vitamin B6 metabolism_Homo sapiens_hsa007500.87493375
64Fanconi anemia pathway_Homo sapiens_hsa034600.87333399
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86315158
66Tryptophan metabolism_Homo sapiens_hsa003800.84843473
67Huntingtons disease_Homo sapiens_hsa050160.84503372
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79732525
69Butanoate metabolism_Homo sapiens_hsa006500.78002195
70Pyrimidine metabolism_Homo sapiens_hsa002400.76145116
71Vibrio cholerae infection_Homo sapiens_hsa051100.76041195
72PPAR signaling pathway_Homo sapiens_hsa033200.74850537
73Collecting duct acid secretion_Homo sapiens_hsa049660.71615633
74RNA degradation_Homo sapiens_hsa030180.68965155
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.67003182
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.66958176
77Protein export_Homo sapiens_hsa030600.65310679
78Tight junction_Homo sapiens_hsa045300.65005469
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63555352
80Mineral absorption_Homo sapiens_hsa049780.59741363
81Ether lipid metabolism_Homo sapiens_hsa005650.57043280
82Protein digestion and absorption_Homo sapiens_hsa049740.56832554
83Tyrosine metabolism_Homo sapiens_hsa003500.55760796
84Biosynthesis of amino acids_Homo sapiens_hsa012300.53373927
85Basal cell carcinoma_Homo sapiens_hsa052170.52767945
86Phenylalanine metabolism_Homo sapiens_hsa003600.49244732
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48479095
88Arachidonic acid metabolism_Homo sapiens_hsa005900.47341912
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45941289
90TGF-beta signaling pathway_Homo sapiens_hsa043500.44595200
91Nitrogen metabolism_Homo sapiens_hsa009100.41793505
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41492306
93Purine metabolism_Homo sapiens_hsa002300.40474381
94Lysosome_Homo sapiens_hsa041420.38634093
95DNA replication_Homo sapiens_hsa030300.38178589
96Linoleic acid metabolism_Homo sapiens_hsa005910.37572282
97Fatty acid biosynthesis_Homo sapiens_hsa000610.35511418
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35475254
99Pentose phosphate pathway_Homo sapiens_hsa000300.34678646
100Lysine degradation_Homo sapiens_hsa003100.34608183

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