JUP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.39163612
2* desmosome organization (GO:0002934)7.71187888
3keratinization (GO:0031424)6.10164436
4molting cycle (GO:0042303)6.07834306
5hair cycle (GO:0042633)6.07834306
6* bundle of His cell to Purkinje myocyte communication (GO:0086069)5.99082476
7regulation of water loss via skin (GO:0033561)5.84354709
8establishment of skin barrier (GO:0061436)5.83336397
9Golgi transport vesicle coating (GO:0048200)4.39894848
10COPI coating of Golgi vesicle (GO:0048205)4.39894848
11multicellular organismal water homeostasis (GO:0050891)4.39416016
12epithelial cell differentiation involved in prostate gland development (GO:0060742)4.34248101
13positive regulation of epidermal cell differentiation (GO:0045606)4.18539948
14cell-substrate junction assembly (GO:0007044)4.16912692
15keratinocyte differentiation (GO:0030216)4.12082286
16plasma membrane repair (GO:0001778)4.08823785
17intermediate filament organization (GO:0045109)4.08541060
18peptide cross-linking (GO:0018149)4.03166158
19sarcomere organization (GO:0045214)4.01521336
20positive regulation of Cdc42 GTPase activity (GO:0043089)3.91507971
21surfactant homeostasis (GO:0043129)3.80009841
22branching involved in mammary gland duct morphogenesis (GO:0060444)3.75034535
23activation of Rac GTPase activity (GO:0032863)3.68682111
24positive regulation of epidermis development (GO:0045684)3.67495601
25semaphorin-plexin signaling pathway (GO:0071526)3.65353027
26positive regulation of keratinocyte differentiation (GO:0045618)3.64823199
27virion attachment to host cell (GO:0019062)3.61709748
28adhesion of symbiont to host cell (GO:0044650)3.61709748
29skin morphogenesis (GO:0043589)3.61527913
30water homeostasis (GO:0030104)3.57223041
31* ventricular cardiac muscle cell action potential (GO:0086005)3.39354377
32epidermal cell differentiation (GO:0009913)3.38153747
33vascular endothelial growth factor signaling pathway (GO:0038084)3.36587717
34focal adhesion assembly (GO:0048041)3.33433210
35cell-substrate adherens junction assembly (GO:0007045)3.33433210
36epidermis development (GO:0008544)3.32238883
37establishment of tissue polarity (GO:0007164)3.31561598
38establishment of planar polarity (GO:0001736)3.31561598
39* epithelial cell-cell adhesion (GO:0090136)3.22581261
40endothelial cell chemotaxis (GO:0035767)3.20221985
41chemical homeostasis within a tissue (GO:0048875)3.20023761
42adhesion of symbiont to host (GO:0044406)3.18112238
43keratinocyte proliferation (GO:0043616)3.15634553
44regulation of hippo signaling (GO:0035330)3.14589640
45regulation of keratinocyte differentiation (GO:0045616)3.13146866
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12957735
47lymph vessel development (GO:0001945)3.11935204
48basement membrane organization (GO:0071711)3.05919242
49regulation of keratinocyte proliferation (GO:0010837)3.05649047
50regulation of cholesterol homeostasis (GO:2000188)3.05298112
51renal filtration (GO:0097205)3.01747624
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00070393
53lymphangiogenesis (GO:0001946)2.99005587
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97948116
55regulation of p38MAPK cascade (GO:1900744)2.96512268
56polarized epithelial cell differentiation (GO:0030859)2.96484139
57peptidyl-tyrosine autophosphorylation (GO:0038083)2.94822387
58cardiac myofibril assembly (GO:0055003)2.92428114
59negative regulation of cell size (GO:0045792)2.91263902
60actin-myosin filament sliding (GO:0033275)2.91098682
61muscle filament sliding (GO:0030049)2.91098682
62branching involved in salivary gland morphogenesis (GO:0060445)2.90816059
63negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.90013615
64wound healing, spreading of epidermal cells (GO:0035313)2.86183396
65regulation of endothelial cell chemotaxis (GO:2001026)2.86018729
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85491653
67* ectoderm development (GO:0007398)2.81608525
68regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.81465360
69actomyosin structure organization (GO:0031032)2.80958203
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79592842
71ear development (GO:0043583)2.79519812
72regulation of skeletal muscle contraction (GO:0014819)2.78205608
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77028943
74* cell communication involved in cardiac conduction (GO:0086065)2.76777341
75protein retention in ER lumen (GO:0006621)2.76457702
76cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.76114106
77regulation of epidermis development (GO:0045682)2.74890245
78cell differentiation involved in embryonic placenta development (GO:0060706)2.72672967
79glomerular visceral epithelial cell development (GO:0072015)2.71288057
80regulation of cholesterol biosynthetic process (GO:0045540)2.71047687
81planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70006067
82negative regulation of keratinocyte proliferation (GO:0010839)2.69545420
83actin-mediated cell contraction (GO:0070252)2.68946244
84retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68915124
85calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.68294250
86ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.67364571
87maternal placenta development (GO:0001893)2.67166578
88regulation of Cdc42 GTPase activity (GO:0043088)2.67032525
89dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66636920
90proline biosynthetic process (GO:0006561)2.66318527
91mammary gland epithelial cell differentiation (GO:0060644)2.66157100
92intermediate filament cytoskeleton organization (GO:0045104)2.65581614
93regulation of establishment of planar polarity (GO:0090175)2.64980486
94cell migration involved in sprouting angiogenesis (GO:0002042)2.64728902
95apoptotic process involved in morphogenesis (GO:0060561)2.64316749
96interferon-gamma secretion (GO:0072643)2.63911421
97establishment of apical/basal cell polarity (GO:0035089)2.63387988
98intestinal epithelial cell development (GO:0060576)2.63099077
99regulation of epidermal cell differentiation (GO:0045604)2.62514158
100regulation of glomerular filtration (GO:0003093)2.61881468
101intermediate filament-based process (GO:0045103)2.61470188
102negative regulation of potassium ion transmembrane transport (GO:1901380)2.61147983
103negative regulation of catenin import into nucleus (GO:0035414)2.58956219
104myofibril assembly (GO:0030239)2.58565363
105cardiac muscle tissue morphogenesis (GO:0055008)2.58502286
106mesodermal cell differentiation (GO:0048333)2.57612840
107cardiac right ventricle morphogenesis (GO:0003215)2.57468035
108gap junction assembly (GO:0016264)2.57347045
109face development (GO:0060324)2.56644473
110regulation of tight junction assembly (GO:2000810)2.56531376
111cell-cell junction maintenance (GO:0045217)2.56164678
112* cell-cell junction assembly (GO:0007043)2.56071423
113regulation of apoptotic process involved in morphogenesis (GO:1902337)2.54932118
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54875027
115trophectodermal cell differentiation (GO:0001829)2.53509290
116glomerular basement membrane development (GO:0032836)2.52765329
117regulation of transforming growth factor beta2 production (GO:0032909)2.51910077
118* cell junction organization (GO:0034330)2.50666859
119negative regulation of chondrocyte differentiation (GO:0032331)2.49392791
120heart trabecula formation (GO:0060347)2.48482268
121* regulation of cardioblast differentiation (GO:0051890)2.48425545
122outflow tract septum morphogenesis (GO:0003148)2.47997205
123linoleic acid metabolic process (GO:0043651)2.47634995
124carnitine shuttle (GO:0006853)2.47604192
125regulation of transforming growth factor beta1 production (GO:0032908)2.46902574
126* cell junction assembly (GO:0034329)2.46499580
127renal system development (GO:0072001)2.46338739
128hippo signaling (GO:0035329)2.44635715
129glomerular epithelial cell development (GO:0072310)2.44177218
130muscle tissue morphogenesis (GO:0060415)2.42458519
131apical protein localization (GO:0045176)2.41737776
132asymmetric protein localization (GO:0008105)2.41170890
133positive regulation of p38MAPK cascade (GO:1900745)2.40160853
134adherens junction assembly (GO:0034333)2.39029530
135endothelial cell morphogenesis (GO:0001886)2.38819871
136negative regulation of viral release from host cell (GO:1902187)2.38263919
137actin filament-based movement (GO:0030048)2.38248679
138regulation of ruffle assembly (GO:1900027)2.38060325
139tight junction assembly (GO:0070830)2.37799189
140regulation of hair follicle development (GO:0051797)2.37712112
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.37428997
142establishment of monopolar cell polarity (GO:0061162)2.37428997
143glucose catabolic process (GO:0006007)2.36463782
144protein localization to endosome (GO:0036010)2.36142719
145NADH metabolic process (GO:0006734)2.35375118
146cardiac muscle cell development (GO:0055013)2.35313516
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.35300235
148amyloid precursor protein metabolic process (GO:0042982)2.35161726
149cardiac cell development (GO:0055006)2.33560023
150endodermal cell differentiation (GO:0035987)2.32578107
151vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31420808
152regulation of endothelial cell differentiation (GO:0045601)2.30684866
153blood vessel endothelial cell migration (GO:0043534)2.30423202
154cardiac muscle contraction (GO:0060048)2.30137796
155keratinocyte development (GO:0003334)2.29909762
156renal system process involved in regulation of blood volume (GO:0001977)2.29711843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51251254
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.90704226
3ZNF263_19887448_ChIP-Seq_K562_Human2.90154426
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80359606
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76392125
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.71360861
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.62843310
8* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.07917986
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06570458
10* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.00478138
11TP63_17297297_ChIP-ChIP_HaCaT_Human10.4490051
12CLOCK_20551151_ChIP-Seq_293T_Human1.99164377
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95116345
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73260970
15* RACK7_27058665_Chip-Seq_MCF-7_Human1.73150894
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.72561685
17* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69509601
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.66417002
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64591429
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63485493
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63485493
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62873830
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61428632
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60996497
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60067762
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.54710998
27* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52109239
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.51668028
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51573148
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.49711929
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47679449
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47335240
33TCF7_22412390_ChIP-Seq_EML_Mouse1.47328318
34* TBX20_22080862_ChIP-Seq_HEART_Mouse1.46788151
35* TBX20_22328084_ChIP-Seq_HEART_Mouse1.46788151
36ATF3_27146783_Chip-Seq_COLON_Human1.43059352
37* SOX2_20726797_ChIP-Seq_SW620_Human1.42699866
38LXR_22292898_ChIP-Seq_THP-1_Human1.42648677
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40653136
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40554288
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39941103
42SMC4_20622854_ChIP-Seq_HELA_Human1.39543413
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36448782
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35451558
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33648334
46CJUN_26792858_Chip-Seq_BT549_Human1.31090853
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29987071
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29819833
49KDM2B_26808549_Chip-Seq_K562_Human1.27504873
50* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27347354
51* GATA2_21666600_ChIP-Seq_HMVEC_Human1.26228163
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.25611227
53VDR_21846776_ChIP-Seq_THP-1_Human1.25307235
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24560768
55* KLF5_25053715_ChIP-Seq_YYC3_Human1.24121851
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23943673
57AHR_22903824_ChIP-Seq_MCF-7_Human1.23186976
58* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22334505
59* TP63_22573176_ChIP-Seq_HFKS_Human1.22039746
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21904557
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20404891
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19342060
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18804392
64* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18139210
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.15875631
66* GATA4_25053715_ChIP-Seq_YYC3_Human1.15279465
67* GATA6_25053715_ChIP-Seq_YYC3_Human1.15040307
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14167175
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13819492
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13819492
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13819492
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13773570
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.12721476
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11882485
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11335356
76MYC_22102868_ChIP-Seq_BL_Human1.10936846
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09882135
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09736466
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08602934
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07188289
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06801707
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05922643
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05618633
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.05296298
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04233903
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04107794
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.02566726
88CTCF_27219007_Chip-Seq_Bcells_Human1.02195754
89* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01962601
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01035598
91* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00846642
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99210173
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98941915
94* GATA3_24758297_ChIP-Seq_MCF-7_Human0.98854082
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98616852
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98327709
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97900461
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.97869961
99* BCOR_27268052_Chip-Seq_Bcells_Human0.97865862
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96438244
101* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95116645
102* TET1_21490601_ChIP-Seq_MESCs_Mouse0.94792428
103TP53_22127205_ChIP-Seq_IMR90_Human0.94596616
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94508587
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94354564
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93963959
107* TP63_23658742_ChIP-Seq_EP156T_Human0.93142752
108CHD1_26751641_Chip-Seq_LNCaP_Human0.93022126
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.91979702
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91129070
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91118207
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.90659245
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89986054
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89571339
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89204805
116* NCOR1_26117541_ChIP-Seq_K562_Human0.88698415
117* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88155794
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88064412
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87507201
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87465662
121KDM2B_26808549_Chip-Seq_DND41_Human0.86872893
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85692047
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.84295122
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83273558
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82688317
126* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81552345
127P68_20966046_ChIP-Seq_HELA_Human0.81243764
128CREB1_26743006_Chip-Seq_LNCaP_Human0.80532500
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79977327
130* RXR_22158963_ChIP-Seq_LIVER_Mouse0.79651257
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79566372
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79537344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier4.72693297
2MP0010234_abnormal_vibrissa_follicle4.38999790
3* MP0005275_abnormal_skin_tensile3.83496315
4MP0003705_abnormal_hypodermis_morpholog3.70344175
5MP0000579_abnormal_nail_morphology3.52368166
6* MP0005501_abnormal_skin_physiology2.96853155
7MP0003941_abnormal_skin_development2.96147367
8MP0003566_abnormal_cell_adhesion2.88002731
9MP0005409_darkened_coat_color2.62952956
10MP0004272_abnormal_basement_membrane2.61002568
11MP0002060_abnormal_skin_morphology2.57237567
12MP0002098_abnormal_vibrissa_morphology2.55559974
13MP0010678_abnormal_skin_adnexa2.45539313
14MP0000383_abnormal_hair_follicle2.38118246
15MP0004084_abnormal_cardiac_muscle2.30213170
16MP0003453_abnormal_keratinocyte_physiol2.29791664
17MP0002254_reproductive_system_inflammat2.28710261
18MP0000467_abnormal_esophagus_morphology2.16204401
19* MP0001216_abnormal_epidermal_layer2.12953962
20MP0000762_abnormal_tongue_morphology1.94899489
21MP0000647_abnormal_sebaceous_gland1.93228873
22MP0002837_dystrophic_cardiac_calcinosis1.90331233
23MP0000751_myopathy1.88887522
24MP0001849_ear_inflammation1.83787422
25* MP0010771_integument_phenotype1.83750122
26MP0000377_abnormal_hair_follicle1.79194801
27MP0000678_abnormal_parathyroid_gland1.76753160
28MP0004185_abnormal_adipocyte_glucose1.75619066
29MP0010368_abnormal_lymphatic_system1.74794089
30MP0002234_abnormal_pharynx_morphology1.69716697
31MP0008438_abnormal_cutaneous_collagen1.65747274
32MP0005451_abnormal_body_composition1.58032391
33MP0000537_abnormal_urethra_morphology1.54735473
34MP0004264_abnormal_extraembryonic_tissu1.43305743
35MP0005330_cardiomyopathy1.42612014
36MP0000427_abnormal_hair_cycle1.41903734
37MP0006138_congestive_heart_failure1.41603560
38MP0004036_abnormal_muscle_relaxation1.41349662
39MP0000750_abnormal_muscle_regeneration1.39651193
40MP0010030_abnormal_orbit_morphology1.36659426
41MP0000566_synostosis1.35405295
42MP0001879_abnormal_lymphatic_vessel1.35275943
43MP0005623_abnormal_meninges_morphology1.34975950
44MP0004947_skin_inflammation1.30499892
45MP0010352_gastrointestinal_tract_polyps1.30445497
46MP0000749_muscle_degeneration1.29445145
47MP0005666_abnormal_adipose_tissue1.25923478
48MP0003828_pulmonary_edema1.24931829
49MP0005023_abnormal_wound_healing1.22884638
50* MP0004087_abnormal_muscle_fiber1.21287517
51MP0004215_abnormal_myocardial_fiber1.20327131
52MP0009780_abnormal_chondrocyte_physiolo1.19593925
53MP0005375_adipose_tissue_phenotype1.16441713
54MP0004381_abnormal_hair_follicle1.15661701
55* MP0002972_abnormal_cardiac_muscle1.15012758
56MP0005670_abnormal_white_adipose1.14184328
57MP0008260_abnormal_autophagy1.11341112
58MP0009379_abnormal_foot_pigmentation1.10219403
59MP0001544_abnormal_cardiovascular_syste1.09626719
60MP0005385_cardiovascular_system_phenoty1.09626719
61MP0002877_abnormal_melanocyte_morpholog1.08077441
62MP0008775_abnormal_heart_ventricle1.07822696
63MP0001958_emphysema1.07146982
64* MP0010630_abnormal_cardiac_muscle1.05654194
65MP0008004_abnormal_stomach_pH1.04943223
66* MP0009931_abnormal_skin_appearance1.04464938
67MP0009053_abnormal_anal_canal1.03790448
68MP0000003_abnormal_adipose_tissue1.02865790
69MP0003878_abnormal_ear_physiology1.02860346
70MP0005377_hearing/vestibular/ear_phenot1.02860346
71MP0001243_abnormal_dermal_layer1.02841380
72MP0003950_abnormal_plasma_membrane1.00374340
73MP0005620_abnormal_muscle_contractility0.99914806
74MP0003315_abnormal_perineum_morphology0.99528389
75MP0002249_abnormal_larynx_morphology0.99033699
76MP0001191_abnormal_skin_condition0.98002504
77MP0005167_abnormal_blood-brain_barrier0.97292747
78MP0006054_spinal_hemorrhage0.95637314
79MP0001346_abnormal_lacrimal_gland0.94924785
80MP0000013_abnormal_adipose_tissue0.93792693
81MP0005083_abnormal_biliary_tract0.88675848
82MP0004782_abnormal_surfactant_physiolog0.87179985
83MP0005076_abnormal_cell_differentiation0.86276072
84MP0005367_renal/urinary_system_phenotyp0.85373504
85MP0000516_abnormal_urinary_system0.85373504
86MP0004858_abnormal_nervous_system0.83719784
87MP0004130_abnormal_muscle_cell0.83245290
88MP0003191_abnormal_cellular_cholesterol0.83071575
89MP0004484_altered_response_of0.82724167
90MP0000733_abnormal_muscle_development0.82703945
91MP0003279_aneurysm0.81517629
92MP0001881_abnormal_mammary_gland0.81409910
93MP0003045_fibrosis0.80815110
94MP0002106_abnormal_muscle_physiology0.80679138
95MP0005248_abnormal_Harderian_gland0.79907072
96MP0004233_abnormal_muscle_weight0.78624383
97MP0009840_abnormal_foam_cell0.78452664
98MP0000462_abnormal_digestive_system0.77908536
99MP0005165_increased_susceptibility_to0.77299101
100MP0005058_abnormal_lysosome_morphology0.77171620
101MP0005360_urolithiasis0.76628589
102MP0002896_abnormal_bone_mineralization0.76467234
103MP0000367_abnormal_coat/_hair0.76116485
104MP0000767_abnormal_smooth_muscle0.74681326
105MP0000759_abnormal_skeletal_muscle0.74347945
106MP0003385_abnormal_body_wall0.72614961
107MP0000534_abnormal_ureter_morphology0.72306380
108MP0000538_abnormal_urinary_bladder0.72111828
109MP0000627_abnormal_mammary_gland0.71781212
110MP0003091_abnormal_cell_migration0.70734133
111MP0000858_altered_metastatic_potential0.70238825
112MP0003137_abnormal_impulse_conducting0.69542162
113MP0003300_gastrointestinal_ulcer0.69508398
114MP0005257_abnormal_intraocular_pressure0.69301687
115* MP0001784_abnormal_fluid_regulation0.69276266
116MP0002089_abnormal_postnatal_growth/wei0.68748746
117MP0008961_abnormal_basal_metabolism0.67954306
118MP0002269_muscular_atrophy0.66569054
119MP0005369_muscle_phenotype0.64955679
120MP0001340_abnormal_eyelid_morphology0.64334097
121MP0005508_abnormal_skeleton_morphology0.64015893
122MP0001765_abnormal_ion_homeostasis0.62942591
123MP0004019_abnormal_vitamin_homeostasis0.62294645
124MP0000477_abnormal_intestine_morphology0.61701847
125MP0002111_abnormal_tail_morphology0.61192886
126MP0003638_abnormal_response/metabolism_0.58734312
127MP0001666_abnormal_nutrient_absorption0.57843991
128MP0001188_hyperpigmentation0.56119926
129* MP0002086_abnormal_extraembryonic_tissu0.53624186
130MP0002282_abnormal_trachea_morphology0.49608383
131MP0009672_abnormal_birth_weight0.49474611
132MP0001727_abnormal_embryo_implantation0.49376594
133MP0000470_abnormal_stomach_morphology0.49278987
134MP0004197_abnormal_fetal_growth/weight/0.47540306
135MP0003755_abnormal_palate_morphology0.47472866
136MP0001730_embryonic_growth_arrest0.46276106
137MP0003183_abnormal_peptide_metabolism0.45507267
138MP0003123_paternal_imprinting0.45111513
139MP0009643_abnormal_urine_homeostasis0.44865698
140MP0003115_abnormal_respiratory_system0.43652765
141MP0001873_stomach_inflammation0.43372588

Predicted human phenotypes

RankGene SetZ-score
1* Right ventricular cardiomyopathy (HP:0011663)6.18276731
2Onycholysis (HP:0001806)5.44586635
3Milia (HP:0001056)5.34832373
4Hypotrichosis (HP:0001006)5.28206459
5Fragile nails (HP:0001808)5.15165708
6Plantar hyperkeratosis (HP:0007556)4.95012384
7Pili torti (HP:0003777)4.63708197
8Hyporeflexia of lower limbs (HP:0002600)4.54776749
9Atrophic scars (HP:0001075)4.54246279
10* Ventricular tachycardia (HP:0004756)4.24941561
11Increased connective tissue (HP:0009025)4.17286149
12Muscle fiber splitting (HP:0003555)4.10160598
13* Woolly hair (HP:0002224)4.04544283
14Palmoplantar hyperkeratosis (HP:0000972)3.98493925
15Alopecia of scalp (HP:0002293)3.77913217
16Palmar hyperkeratosis (HP:0010765)3.72503723
17Abnormality of nail color (HP:0100643)3.71903291
18Nail dystrophy (HP:0008404)3.59685927
19Increased IgE level (HP:0003212)3.38878084
20Distal lower limb muscle weakness (HP:0009053)3.38387737
21Thick nail (HP:0001805)3.26730320
22* Sudden death (HP:0001699)3.18803686
23Fragile skin (HP:0001030)3.14070790
24Septate vagina (HP:0001153)2.94468253
25Selective tooth agenesis (HP:0001592)2.86140014
26Difficulty running (HP:0009046)2.83519090
27Conjunctival hamartoma (HP:0100780)2.82566426
28Ventricular fibrillation (HP:0001663)2.79757131
29Flat acetabular roof (HP:0003180)2.75052418
30* Abnormal blistering of the skin (HP:0008066)2.71947483
31* Palmoplantar keratoderma (HP:0000982)2.71294411
32Sparse scalp hair (HP:0002209)2.66453301
33Absent eyelashes (HP:0000561)2.63234681
34Difficulty climbing stairs (HP:0003551)2.60203306
35Oral leukoplakia (HP:0002745)2.59630185
36Abnormal hair laboratory examination (HP:0003328)2.59129825
37Broad face (HP:0000283)2.59016867
38Type 1 muscle fiber predominance (HP:0003803)2.55853250
39Exercise-induced myalgia (HP:0003738)2.51319093
40Ankyloglossia (HP:0010296)2.49246455
41Atrial fibrillation (HP:0005110)2.47729435
42Follicular hyperkeratosis (HP:0007502)2.46520134
43Aplasia cutis congenita (HP:0001057)2.45429260
44Broad metatarsal (HP:0001783)2.44756611
45Mildly elevated creatine phosphokinase (HP:0008180)2.41962036
46Pterygium (HP:0001059)2.41607233
47Abnormality of secondary sexual hair (HP:0009888)2.40891655
48Abnormality of the axillary hair (HP:0100134)2.40891655
49Congenital ichthyosiform erythroderma (HP:0007431)2.40559257
50Ventricular arrhythmia (HP:0004308)2.40149799
51Amelogenesis imperfecta (HP:0000705)2.39485502
52Primary atrial arrhythmia (HP:0001692)2.35326403
53Cerebral aneurysm (HP:0004944)2.33964962
54Premature rupture of membranes (HP:0001788)2.33686395
55Abnormality of the distal phalanges of the toes (HP:0010182)2.33244582
56Abnormality of the calf musculature (HP:0001430)2.32827880
57Supraventricular arrhythmia (HP:0005115)2.28248569
58Exercise-induced muscle cramps (HP:0003710)2.28010752
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27888154
60Lipoatrophy (HP:0100578)2.26054855
61Palpitations (HP:0001962)2.23845140
62Ridged nail (HP:0001807)2.23841106
63Hamartoma of the eye (HP:0010568)2.22010373
64Supraventricular tachycardia (HP:0004755)2.22000231
65Calf muscle hypertrophy (HP:0008981)2.20549451
66Thin bony cortex (HP:0002753)2.19732773
67Shallow orbits (HP:0000586)2.19349030
68Abnormality of the dental root (HP:0006486)2.16512551
69Taurodontia (HP:0000679)2.16512551
70Abnormality of permanent molar morphology (HP:0011071)2.16512551
71Trismus (HP:0000211)2.15479792
72EMG: myopathic abnormalities (HP:0003458)2.14256856
73Spinal rigidity (HP:0003306)2.13850249
74Blepharitis (HP:0000498)2.12102489
75Natal tooth (HP:0000695)2.10574596
76Increased variability in muscle fiber diameter (HP:0003557)2.09134567
77Bronchomalacia (HP:0002780)2.08194280
78Hypoplasia of dental enamel (HP:0006297)2.06100357
79Hyperacusis (HP:0010780)2.05573941
80Scapular winging (HP:0003691)2.04666332
81Fatigable weakness (HP:0003473)2.04475670
82Abnormality of the neuromuscular junction (HP:0003398)2.04475670
83Oligodontia (HP:0000677)2.02923025
84Lip pit (HP:0100267)2.01275054
85Neonatal death (HP:0003811)1.98448314
86Erythema (HP:0010783)1.98065346
87Cervical subluxation (HP:0003308)1.98063816
88Corneal erosion (HP:0200020)1.97362835
89Abnormality of molar (HP:0011077)1.96829430
90Abnormality of molar morphology (HP:0011070)1.96829430
91Hypoplastic labia majora (HP:0000059)1.96783784
92Abnormality of oral frenula (HP:0000190)1.96694984
93Axonal loss (HP:0003447)1.93231816
94Rectal prolapse (HP:0002035)1.92764008
95Abnormality of skeletal muscle fiber size (HP:0012084)1.92745604
96Sparse eyelashes (HP:0000653)1.91706306
97Protrusio acetabuli (HP:0003179)1.89944481
98Muscle hypertrophy of the lower extremities (HP:0008968)1.89928156
99Upper limb amyotrophy (HP:0009129)1.89911797
100Distal upper limb amyotrophy (HP:0007149)1.89911797
101Short nail (HP:0001799)1.89570435
102Lymphangioma (HP:0100764)1.89215704
103Malnutrition (HP:0004395)1.88833883
104Round ear (HP:0100830)1.88751559
105* Acanthosis nigricans (HP:0000956)1.87611383
106Distal lower limb amyotrophy (HP:0008944)1.87063476
107Myoglobinuria (HP:0002913)1.86673467
108Parakeratosis (HP:0001036)1.86441675
109Erythroderma (HP:0001019)1.86351642
110* Syncope (HP:0001279)1.85761050
111* Anonychia (HP:0001798)1.85087522
112Abnormal atrioventricular conduction (HP:0005150)1.84122241
113Abnormality of the dental pulp (HP:0006479)1.83773751
114Bundle branch block (HP:0011710)1.81968567
115Nasolacrimal duct obstruction (HP:0000579)1.81655546
116Neck muscle weakness (HP:0000467)1.81604271
117Germ cell neoplasia (HP:0100728)1.81313292
118Areflexia of lower limbs (HP:0002522)1.78741033
119Down-sloping shoulders (HP:0200021)1.78260576
120Mesangial abnormality (HP:0001966)1.77970285
121Esophageal varix (HP:0002040)1.76908165
122Laryngomalacia (HP:0001601)1.76849502
123Prolonged QT interval (HP:0001657)1.76540249
124Abnormality of the salivary glands (HP:0010286)1.75297228
125* Advanced eruption of teeth (HP:0006288)1.75163739
126Ankle contracture (HP:0006466)1.74852031
127Carious teeth (HP:0000670)1.73067236
128Esophageal atresia (HP:0002032)1.72866799
129* Dilated cardiomyopathy (HP:0001644)1.72745498
130Abnormality of the labia majora (HP:0012881)1.72687759
131Deviation of the thumb (HP:0009603)1.72593273
132Unilateral renal agenesis (HP:0000122)1.70420911
133Popliteal pterygium (HP:0009756)1.69584632
134Achilles tendon contracture (HP:0001771)1.68436098
135Myotonia (HP:0002486)1.66825030
136Focal segmental glomerulosclerosis (HP:0000097)1.65929388
137Ectropion (HP:0000656)1.65499118
138Hyperparathyroidism (HP:0000843)1.64161090
139Hyperactive renin-angiotensin system (HP:0000841)1.63908982
140Dehydration (HP:0001944)1.63611235
141Obstructive sleep apnea (HP:0002870)1.63345127
142Hypohidrosis (HP:0000966)1.62963754
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.62456667
144Seborrheic dermatitis (HP:0001051)1.62148457
145Abdominal distention (HP:0003270)1.60150651
146Sparse lateral eyebrow (HP:0005338)1.57125022
147Easy fatigability (HP:0003388)1.53042418
148Dry hair (HP:0011359)1.50400096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.07241937
2MAPKAPK33.30954295
3TIE13.07138000
4TTN3.02991318
5EPHB23.01134957
6TRIB32.91243296
7RIPK12.56886729
8SMG12.42525491
9ERN12.33429839
10EPHB12.14779558
11LMTK22.13676247
12LATS12.05607301
13MST1R1.97432009
14MAP3K31.95531697
15TGFBR21.88568005
16KDR1.81685145
17MST41.80917370
18SIK11.78231164
19PTK61.75698674
20IRAK31.71221422
21PKN21.67897393
22PDGFRA1.64382156
23FGFR41.62933560
24RPS6KB21.60360207
25MET1.59377790
26DMPK1.52945759
27PTK21.47548984
28MYLK1.42376626
29MAP3K61.40179702
30MAP2K21.37405115
31PHKG11.36116388
32PHKG21.36116388
33NME21.30450986
34PAK41.25722372
35LRRK21.23264508
36* FER1.18876851
37LATS21.18244545
38MAP3K21.16507342
39STK38L1.16429757
40TRPM71.15834816
41TESK11.14990679
42EPHA31.13069508
43OBSCN1.12807605
44EEF2K1.12267466
45NME11.12078573
46FGFR21.11149576
47BCR1.08783585
48MAPK151.07424090
49WNK41.05257416
50PRKD11.03864977
51DDR21.03725353
52MAP3K111.01999852
53PAK30.92610377
54PRPF4B0.92156313
55NTRK10.88507789
56RPS6KA20.88474983
57PRKG20.85688988
58MAP3K10.85505720
59PRKD20.84733519
60FGFR10.82344610
61ARAF0.81864857
62ICK0.80653602
63MUSK0.79495027
64TESK20.79419530
65LIMK10.77898295
66STK100.76038335
67ROCK10.75392474
68PDK20.74929334
69PIK3CA0.74823445
70MAP2K10.74156085
71STK240.72605513
72ILK0.72432376
73FGFR30.71458639
74PDK40.70994279
75PDK30.70994279
76MTOR0.70574617
77MAP3K70.68978213
78MARK20.67665143
79SCYL20.67146189
80NEK10.67133064
81DYRK1B0.66623720
82MAP2K30.66195445
83TAOK10.66133694
84BMX0.65282362
85CDK70.64851833
86TGFBR10.64601091
87BCKDK0.63538586
88MAP3K100.60779679
89MAPKAPK20.57145596
90RET0.55649151
91PDGFRB0.54927425
92MATK0.54605457
93PRKCI0.54592428
94ERBB20.54501618
95CDC42BPA0.53371122
96NEK60.53202327
97PRKD30.52675035
98PAK20.51628450
99ROCK20.50725140
100TYRO30.50574272
101CDK120.50065951
102KSR20.49815011
103STK380.47221916
104CAMK1D0.46902668
105PIM20.46543234
106RPS6KL10.44316525
107RPS6KC10.44316525
108GRK60.42929671
109GSK3A0.40998279
110SIK30.40731687
111MAP2K60.40527865
112HIPK20.40359063
113CDK60.40042407
114CHUK0.39535700
115STK390.38449827
116AKT20.37570068
117PIK3CG0.36870116
118DAPK30.36550001
119PRKAA20.35915713
120MAP3K90.35767509
121INSRR0.35695983
122RPS6KA10.35675699
123CAMK2D0.34224317
124PBK0.33600998
125MAP3K80.33598971
126WNK10.33294570
127PDPK10.33004409
128FLT30.30509497
129TBK10.30330149
130CDK90.27739069
131RPS6KA60.26103361
132CAMK2G0.24309745
133EIF2AK10.22505048
134RPS6KA40.21179062
135IRAK20.20248132

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.70916715
2* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.70227098
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.65381825
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.45900219
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42336406
6Dilated cardiomyopathy_Homo sapiens_hsa054142.37779647
7Adherens junction_Homo sapiens_hsa045202.32443355
8Tight junction_Homo sapiens_hsa045302.21665584
9Focal adhesion_Homo sapiens_hsa045101.92629354
10Fructose and mannose metabolism_Homo sapiens_hsa000511.91213019
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88799254
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79421486
13Basal cell carcinoma_Homo sapiens_hsa052171.78501678
14Hippo signaling pathway_Homo sapiens_hsa043901.75228997
15Galactose metabolism_Homo sapiens_hsa000521.62483054
16Fatty acid degradation_Homo sapiens_hsa000711.61089982
17Amoebiasis_Homo sapiens_hsa051461.58085982
18Proteoglycans in cancer_Homo sapiens_hsa052051.58006832
19Pentose phosphate pathway_Homo sapiens_hsa000301.55575638
20Fat digestion and absorption_Homo sapiens_hsa049751.54732803
21Bladder cancer_Homo sapiens_hsa052191.51479828
22Protein digestion and absorption_Homo sapiens_hsa049741.51106877
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.51072322
24Other glycan degradation_Homo sapiens_hsa005111.45167967
25Small cell lung cancer_Homo sapiens_hsa052221.39630175
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27067007
27Hedgehog signaling pathway_Homo sapiens_hsa043401.26446911
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23327180
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22338649
30PPAR signaling pathway_Homo sapiens_hsa033201.19490590
31ErbB signaling pathway_Homo sapiens_hsa040121.18199322
32Insulin resistance_Homo sapiens_hsa049311.17537080
33Notch signaling pathway_Homo sapiens_hsa043301.17062652
34Fatty acid metabolism_Homo sapiens_hsa012121.16710729
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16238136
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15443147
37Linoleic acid metabolism_Homo sapiens_hsa005911.14313897
38Cardiac muscle contraction_Homo sapiens_hsa042601.10534769
39Mineral absorption_Homo sapiens_hsa049781.09314300
40Pancreatic cancer_Homo sapiens_hsa052121.08994445
41Biosynthesis of amino acids_Homo sapiens_hsa012301.08796698
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08655031
43Axon guidance_Homo sapiens_hsa043601.06889836
44VEGF signaling pathway_Homo sapiens_hsa043701.05834875
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04671773
46* Acute myeloid leukemia_Homo sapiens_hsa052211.03929169
47Viral myocarditis_Homo sapiens_hsa054161.03471782
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97812192
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.97020681
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96972360
51Phenylalanine metabolism_Homo sapiens_hsa003600.96734550
52Toxoplasmosis_Homo sapiens_hsa051450.96724459
53Propanoate metabolism_Homo sapiens_hsa006400.92438031
54Vitamin digestion and absorption_Homo sapiens_hsa049770.92373434
55Fatty acid elongation_Homo sapiens_hsa000620.91796532
56Choline metabolism in cancer_Homo sapiens_hsa052310.91702478
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91617523
58Inositol phosphate metabolism_Homo sapiens_hsa005620.91240516
59Fatty acid biosynthesis_Homo sapiens_hsa000610.89885336
60Rap1 signaling pathway_Homo sapiens_hsa040150.89568786
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.89098534
62TGF-beta signaling pathway_Homo sapiens_hsa043500.88062520
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.84906656
64Arachidonic acid metabolism_Homo sapiens_hsa005900.84589993
65Dorso-ventral axis formation_Homo sapiens_hsa043200.84270556
66Thyroid cancer_Homo sapiens_hsa052160.83617447
67Caffeine metabolism_Homo sapiens_hsa002320.83611141
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82919529
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81932607
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81664528
71Vibrio cholerae infection_Homo sapiens_hsa051100.81050807
72MicroRNAs in cancer_Homo sapiens_hsa052060.80624304
73Endometrial cancer_Homo sapiens_hsa052130.80570636
74Melanogenesis_Homo sapiens_hsa049160.78586136
75Non-small cell lung cancer_Homo sapiens_hsa052230.78074084
76Renal cell carcinoma_Homo sapiens_hsa052110.77306396
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76642610
78* Pathways in cancer_Homo sapiens_hsa052000.74662821
79Tyrosine metabolism_Homo sapiens_hsa003500.74032895
80Pancreatic secretion_Homo sapiens_hsa049720.73562461
81Arginine and proline metabolism_Homo sapiens_hsa003300.73218522
82Bile secretion_Homo sapiens_hsa049760.72369007
83Glioma_Homo sapiens_hsa052140.71928181
84mTOR signaling pathway_Homo sapiens_hsa041500.69970617
85AMPK signaling pathway_Homo sapiens_hsa041520.68161965
86Histidine metabolism_Homo sapiens_hsa003400.66514397
87N-Glycan biosynthesis_Homo sapiens_hsa005100.66173225
88Insulin signaling pathway_Homo sapiens_hsa049100.66073136
89Renin-angiotensin system_Homo sapiens_hsa046140.65926140
90Ovarian steroidogenesis_Homo sapiens_hsa049130.64518129
91Gastric acid secretion_Homo sapiens_hsa049710.64419011
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64105061
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64031376
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63609528
95Steroid biosynthesis_Homo sapiens_hsa001000.63519368
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63512501
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.63332548
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63110020
99Prion diseases_Homo sapiens_hsa050200.62372652
100Melanoma_Homo sapiens_hsa052180.62256767
101Tryptophan metabolism_Homo sapiens_hsa003800.61963101
102Sulfur metabolism_Homo sapiens_hsa009200.60737905
103Prostate cancer_Homo sapiens_hsa052150.60255222
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.59626732
105Carbon metabolism_Homo sapiens_hsa012000.59060295
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57941442
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57469384
108Prolactin signaling pathway_Homo sapiens_hsa049170.56042038
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55610417
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54773334
111Wnt signaling pathway_Homo sapiens_hsa043100.54628205
112GnRH signaling pathway_Homo sapiens_hsa049120.54406433
113Endocytosis_Homo sapiens_hsa041440.53730187
114Sulfur relay system_Homo sapiens_hsa041220.53341060
115Arginine biosynthesis_Homo sapiens_hsa002200.52215703
116Ras signaling pathway_Homo sapiens_hsa040140.51512111
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51439025
118Estrogen signaling pathway_Homo sapiens_hsa049150.51353330
119beta-Alanine metabolism_Homo sapiens_hsa004100.50959710
120Starch and sucrose metabolism_Homo sapiens_hsa005000.50669761
121Chronic myeloid leukemia_Homo sapiens_hsa052200.49477784
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49336659
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49322144
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.48985264
125HIF-1 signaling pathway_Homo sapiens_hsa040660.48846270
126Sphingolipid metabolism_Homo sapiens_hsa006000.48239148
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47687777
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47630922
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.47418285
130ABC transporters_Homo sapiens_hsa020100.46997096
131Glucagon signaling pathway_Homo sapiens_hsa049220.46811575
132Hepatitis C_Homo sapiens_hsa051600.46599532
133Chemical carcinogenesis_Homo sapiens_hsa052040.46589273
134Lysine degradation_Homo sapiens_hsa003100.45890075
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45477759
136Gap junction_Homo sapiens_hsa045400.45061845

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