JUNB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)7.64068395
2negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.66243288
3response to muramyl dipeptide (GO:0032495)6.19461195
4positive regulation of gamma-delta T cell activation (GO:0046645)5.57670765
5interferon-gamma production (GO:0032609)5.48124232
6regulation of gamma-delta T cell differentiation (GO:0045586)5.38685350
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35309856
8negative regulation of cell killing (GO:0031342)5.35309856
9response to interleukin-15 (GO:0070672)5.30163946
10negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.10328944
11NIK/NF-kappaB signaling (GO:0038061)5.00924737
12regulation of gamma-delta T cell activation (GO:0046643)4.97902948
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97671327
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97671327
15cellular response to interleukin-15 (GO:0071350)4.82874537
16negative regulation of bone resorption (GO:0045779)4.78821165
17positive thymic T cell selection (GO:0045059)4.74571752
18negative T cell selection (GO:0043383)4.71216919
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.68644172
20antigen processing and presentation of endogenous antigen (GO:0019883)4.67165409
21viral protein processing (GO:0019082)4.66124800
22negative thymic T cell selection (GO:0045060)4.46214746
23positive T cell selection (GO:0043368)4.39353384
24endothelial cell chemotaxis (GO:0035767)4.39090815
25regulation of interleukin-12 biosynthetic process (GO:0045075)4.35331696
26thymic T cell selection (GO:0045061)4.19977825
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.18454696
28T cell selection (GO:0045058)4.07135584
29regulation of chronic inflammatory response (GO:0002676)4.05118899
30regulation of B cell receptor signaling pathway (GO:0050855)3.97020391
31negative regulation of bone remodeling (GO:0046851)3.87498568
32response to peptidoglycan (GO:0032494)3.80669542
33negative regulation of interleukin-1 beta production (GO:0032691)3.77972434
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75940423
35regulation of isotype switching to IgG isotypes (GO:0048302)3.74018029
36negative regulation of erythrocyte differentiation (GO:0045647)3.67155008
37detection of other organism (GO:0098543)3.56992325
38mature B cell differentiation involved in immune response (GO:0002313)3.55393822
39detection of bacterium (GO:0016045)3.54071085
40negative regulation of interleukin-12 production (GO:0032695)3.49194689
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.48018355
42T-helper cell differentiation (GO:0042093)3.48018355
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47635512
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.47635512
45modulation by symbiont of host immune response (GO:0052553)3.47635512
46positive regulation by symbiont of host defense response (GO:0052509)3.47635512
47modulation by symbiont of host defense response (GO:0052031)3.47635512
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47635512
49regulation of T cell tolerance induction (GO:0002664)3.45416454
50mature B cell differentiation (GO:0002335)3.43639004
51regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.37769611
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.37518081
53neutrophil activation involved in immune response (GO:0002283)3.35983291
54negative regulation of tissue remodeling (GO:0034104)3.34723386
55regulation of response to interferon-gamma (GO:0060330)3.34101965
56negative regulation of T cell mediated immunity (GO:0002710)3.31254166
57cellular response to type I interferon (GO:0071357)3.30648152
58type I interferon signaling pathway (GO:0060337)3.30648152
59positive regulation of interleukin-2 production (GO:0032743)3.29907156
60response to type I interferon (GO:0034340)3.29123726
61virion assembly (GO:0019068)3.28963916
62T cell migration (GO:0072678)3.28250723
63negative regulation of innate immune response (GO:0045824)3.27077633
64regulation of germinal center formation (GO:0002634)3.26718899
65T cell receptor signaling pathway (GO:0050852)3.26549804
66macrophage activation involved in immune response (GO:0002281)3.26450583
67germinal center formation (GO:0002467)3.25450564
68cellular extravasation (GO:0045123)3.24949176
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22998885
70immunoglobulin mediated immune response (GO:0016064)3.19419969
71response to laminar fluid shear stress (GO:0034616)3.19112087
72alpha-beta T cell differentiation (GO:0046632)3.17893325
73negative regulation of interleukin-1 production (GO:0032692)3.16515764
74positive regulation of natural killer cell differentiation (GO:0032825)3.12993178
75leukocyte aggregation (GO:0070486)3.12913738
76nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.11793897
77alpha-beta T cell activation (GO:0046631)3.11704409
78myeloid dendritic cell differentiation (GO:0043011)3.09755749
79regulation of regulatory T cell differentiation (GO:0045589)3.09615689
80regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.07707778
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.06422259
82myeloid dendritic cell activation (GO:0001773)3.04603695
83positive regulation of p38MAPK cascade (GO:1900745)3.04202727
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.02904092
85alpha-beta T cell activation involved in immune response (GO:0002287)3.02904092
86T cell differentiation involved in immune response (GO:0002292)3.02904092
87regulation of alpha-beta T cell proliferation (GO:0046640)3.02701990
88negative regulation of interleukin-6 production (GO:0032715)3.02078126
89tumor necrosis factor-mediated signaling pathway (GO:0033209)3.01613077
90regulation of interleukin-2 production (GO:0032663)3.01336216
91positive regulation of isotype switching (GO:0045830)2.99836766
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.95700632
93leukocyte cell-cell adhesion (GO:0007159)2.95227712
94regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.91771939
95defense response to protozoan (GO:0042832)2.91475349
96negative regulation of inclusion body assembly (GO:0090084)2.91140547
97neutrophil activation (GO:0042119)2.90301789
98positive regulation of heat generation (GO:0031652)2.89960359
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89892865
100positive regulation of tolerance induction (GO:0002645)2.89528980
101response to protozoan (GO:0001562)2.88271586
102granulocyte activation (GO:0036230)2.87064854
103regulation of fever generation (GO:0031620)2.86851127
104B cell homeostasis (GO:0001782)2.85836266
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85706261
106detection of external biotic stimulus (GO:0098581)2.85383254
107negative regulation of cytokine production involved in immune response (GO:0002719)2.83345378
108cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.83116819
109regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82407383
110antigen receptor-mediated signaling pathway (GO:0050851)2.82018507
111T cell differentiation (GO:0030217)2.81882832
112negative regulation of leukocyte mediated immunity (GO:0002704)2.80266672
113positive regulation of B cell differentiation (GO:0045579)2.79287252
114mannose metabolic process (GO:0006013)2.78595448
115endoderm formation (GO:0001706)2.77098005
116protein K11-linked deubiquitination (GO:0035871)2.76906548
117negative regulation of toll-like receptor signaling pathway (GO:0034122)2.76845266
118regulation of p38MAPK cascade (GO:1900744)2.74894157
119T cell costimulation (GO:0031295)2.74886030
120regulation of interferon-beta biosynthetic process (GO:0045357)2.73638603
121regulation of T-helper 2 cell differentiation (GO:0045628)2.72448156
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72103298
123interferon-gamma-mediated signaling pathway (GO:0060333)2.71894354
124lymphocyte homeostasis (GO:0002260)2.70390936
125leukocyte tethering or rolling (GO:0050901)2.68668267
126lymphocyte costimulation (GO:0031294)2.68150907
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67668274
128regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.66475173
129regulation of natural killer cell mediated immunity (GO:0002715)2.66475173
130growth hormone receptor signaling pathway (GO:0060396)2.66222670
131myeloid cell activation involved in immune response (GO:0002275)2.65409725
132JAK-STAT cascade (GO:0007259)2.64832636
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.64074594
134interleukin-1-mediated signaling pathway (GO:0070498)2.63655136
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63169187
136regulation of bone resorption (GO:0045124)2.62975414
137regulation of T-helper 1 cell differentiation (GO:0045625)2.62639974
138regulation of tolerance induction (GO:0002643)2.62450757
139regulation of B cell differentiation (GO:0045577)2.61912331
140detection of biotic stimulus (GO:0009595)2.61280033
141antigen processing and presentation via MHC class Ib (GO:0002475)2.60624320
142regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60275583
143positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.56953486
144B cell receptor signaling pathway (GO:0050853)2.55064506
145regulation of alpha-beta T cell activation (GO:0046634)2.54321390
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54218351
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54036008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.44129379
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.80101452
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.49888938
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.08960757
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.60796467
6RUNX_20019798_ChIP-Seq_JUKART_Human3.32623012
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.25929170
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.12211702
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.08390621
10* MYC_22102868_ChIP-Seq_BL_Human2.94496509
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57808029
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.55476345
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54743720
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52684276
15SCL_19346495_ChIP-Seq_HPC-7_Human2.46812480
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42816007
17* MYB_26560356_Chip-Seq_TH2_Human2.40059424
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.38896314
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36082554
20* MAF_26560356_Chip-Seq_TH1_Human2.31815378
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31073988
22CLOCK_20551151_ChIP-Seq_293T_Human2.29319890
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.29312473
24* IRF8_27001747_Chip-Seq_BMDM_Mouse2.20283964
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.15888670
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10575577
27* MYB_26560356_Chip-Seq_TH1_Human2.07950955
28* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05862600
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00525660
30* KDM2B_26808549_Chip-Seq_DND41_Human1.96044934
31* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94528117
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92049023
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90490730
34* VDR_21846776_ChIP-Seq_THP-1_Human1.89284763
35* UTX_26944678_Chip-Seq_JUKART_Human1.89236573
36VDR_24763502_ChIP-Seq_THP-1_Human1.85529631
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.82995508
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81820079
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.78088998
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77202754
41* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71692944
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68847113
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66441429
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64879323
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64675288
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60422724
47* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55388516
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53012290
49* KDM2B_26808549_Chip-Seq_JURKAT_Human1.50454950
50GATA3_27048872_Chip-Seq_THYMUS_Human1.50050835
51MAF_26560356_Chip-Seq_TH2_Human1.43809036
52VDR_24787735_ChIP-Seq_THP-1_Human1.43691123
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.40387642
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38427998
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37931228
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33921117
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32368848
58SPI1_23127762_ChIP-Seq_K562_Human1.26418146
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24836060
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24707686
61ZNF263_19887448_ChIP-Seq_K562_Human1.21661938
62* ESR2_21235772_ChIP-Seq_MCF-7_Human1.21508773
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20383528
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17274355
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15365971
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15124977
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14555665
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13420079
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13263282
70* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13170540
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12749648
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12648501
73* GATA1_19941826_ChIP-Seq_K562_Human1.12407562
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08652486
75PU_27001747_Chip-Seq_BMDM_Mouse1.08457216
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08204893
77* SPI1_23547873_ChIP-Seq_NB4_Human1.06634374
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05660413
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.05379576
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.04979142
81* GATA2_19941826_ChIP-Seq_K562_Human1.04319539
82KDM2B_26808549_Chip-Seq_K562_Human1.03819695
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02490712
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01548286
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01012535
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.00514691
87LXR_22292898_ChIP-Seq_THP-1_Human1.00354185
88ATF3_27146783_Chip-Seq_COLON_Human0.99852006
89* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99599943
90* RACK7_27058665_Chip-Seq_MCF-7_Human0.99389304
91* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99120880
92BCOR_27268052_Chip-Seq_Bcells_Human0.98957473
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98210587
94* ESR1_21235772_ChIP-Seq_MCF-7_Human0.98020246
95* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97401164
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97222845
97* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97185186
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96633977
99* BCL6_27268052_Chip-Seq_Bcells_Human0.96515060
100* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95588488
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95073362
102* NCOR1_26117541_ChIP-Seq_K562_Human0.94842839
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93915817
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92655583
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92460416
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92222694
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.92182568
108* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90527103
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89956974
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88323799
111* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86732327
112* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86732327
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86408865
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85503948
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85004572
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.84013947
117* ELF1_20517297_ChIP-Seq_JURKAT_Human0.83271097
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83134399
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82651254
120* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81280102
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81234228
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81212102
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81196450
124GATA3_26560356_Chip-Seq_TH2_Human0.80128526
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.79906256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.97582468
2MP0003763_abnormal_thymus_physiology3.76344788
3MP0003724_increased_susceptibility_to3.54516659
4MP0004510_myositis3.16678292
5MP0003303_peritoneal_inflammation3.09525549
6MP0005671_abnormal_response_to3.03527335
7MP0005387_immune_system_phenotype3.01439011
8MP0001790_abnormal_immune_system3.01439011
9* MP0005000_abnormal_immune_tolerance2.79195342
10MP0003436_decreased_susceptibility_to2.71773582
11* MP0001800_abnormal_humoral_immune2.69126016
12MP0003300_gastrointestinal_ulcer2.61666116
13MP0002138_abnormal_hepatobiliary_system2.55215431
14MP0001835_abnormal_antigen_presentation2.51424922
15* MP0002723_abnormal_immune_serum2.51276431
16MP0002405_respiratory_system_inflammati2.46715390
17MP0006082_CNS_inflammation2.39308867
18* MP0002452_abnormal_antigen_presenting2.34205631
19* MP0002420_abnormal_adaptive_immunity2.25328669
20* MP0004947_skin_inflammation2.23193316
21* MP0001819_abnormal_immune_cell2.23176631
22MP0002933_joint_inflammation2.22020723
23MP0009785_altered_susceptibility_to2.21438615
24MP0010155_abnormal_intestine_physiology2.18095519
25MP0001851_eye_inflammation2.11794921
26MP0009278_abnormal_bone_marrow2.10910214
27MP0002166_altered_tumor_susceptibility2.08696499
28MP0002419_abnormal_innate_immunity2.02667601
29MP0002148_abnormal_hypersensitivity_rea1.98973738
30MP0005025_abnormal_response_to1.94755763
31MP0002398_abnormal_bone_marrow1.94631772
32MP0001873_stomach_inflammation1.92228820
33* MP0000716_abnormal_immune_system1.83165073
34MP0002254_reproductive_system_inflammat1.78988882
35MP0001853_heart_inflammation1.78461709
36MP0005058_abnormal_lysosome_morphology1.76793240
37MP0009333_abnormal_splenocyte_physiolog1.76365205
38* MP0001845_abnormal_inflammatory_respons1.70898823
39MP0000703_abnormal_thymus_morphology1.70088026
40MP0003866_abnormal_defecation1.63864817
41MP0002006_tumorigenesis1.62866288
42* MP0001533_abnormal_skeleton_physiology1.60364897
43MP0000858_altered_metastatic_potential1.60115853
44MP0002722_abnormal_immune_system1.59956291
45MP0000465_gastrointestinal_hemorrhage1.57365768
46MP0001545_abnormal_hematopoietic_system1.57054941
47MP0005397_hematopoietic_system_phenotyp1.57054941
48MP0000689_abnormal_spleen_morphology1.56545011
49MP0008007_abnormal_cellular_replicative1.52057374
50MP0010352_gastrointestinal_tract_polyps1.50714516
51MP0005076_abnormal_cell_differentiation1.48210322
52MP0008004_abnormal_stomach_pH1.46784587
53MP0008961_abnormal_basal_metabolism1.46111110
54* MP0002429_abnormal_blood_cell1.45577174
55MP0003172_abnormal_lysosome_physiology1.44206008
56MP0005464_abnormal_platelet_physiology1.44127499
57MP0004808_abnormal_hematopoietic_stem1.43557224
58MP0003075_altered_response_to1.43148659
59MP0003453_abnormal_keratinocyte_physiol1.38710926
60MP0002877_abnormal_melanocyte_morpholog1.33651442
61MP0003448_altered_tumor_morphology1.31567955
62MP0005451_abnormal_body_composition1.30193860
63MP0008260_abnormal_autophagy1.21069001
64* MP0002998_abnormal_bone_remodeling1.20846908
65MP0000343_altered_response_to1.17950685
66MP0003045_fibrosis1.16828567
67MP0003828_pulmonary_edema1.16138997
68MP0005310_abnormal_salivary_gland1.14916901
69MP0003566_abnormal_cell_adhesion1.13892075
70MP0002277_abnormal_respiratory_mucosa1.13755399
71MP0003091_abnormal_cell_migration1.11292031
72MP0005023_abnormal_wound_healing1.09884654
73* MP0008469_abnormal_protein_level1.09742022
74MP0001243_abnormal_dermal_layer1.07581194
75MP0004381_abnormal_hair_follicle1.04798709
76MP0000249_abnormal_blood_vessel1.04522452
77MP0002928_abnormal_bile_duct1.03270449
78MP0005164_abnormal_response_to1.02879435
79MP0004883_abnormal_blood_vessel0.99883148
80MP0002396_abnormal_hematopoietic_system0.98236228
81MP0010368_abnormal_lymphatic_system0.93485711
82MP0000604_amyloidosis0.91940049
83MP0003279_aneurysm0.90170615
84MP0005166_decreased_susceptibility_to0.89790087
85MP0001216_abnormal_epidermal_layer0.88384456
86MP0000609_abnormal_liver_physiology0.87827586
87* MP0005390_skeleton_phenotype0.87333793
88MP0001881_abnormal_mammary_gland0.83412027
89* MP0003795_abnormal_bone_structure0.80443337
90MP0001348_abnormal_lacrimal_gland0.80068694
91MP0001663_abnormal_digestive_system0.79651365
92MP0009840_abnormal_foam_cell0.78500248
93MP0003690_abnormal_glial_cell0.77476110
94MP0005165_increased_susceptibility_to0.75723982
95MP0003656_abnormal_erythrocyte_physiolo0.75492459
96MP0009763_increased_sensitivity_to0.74458633
97MP0003191_abnormal_cellular_cholesterol0.74156330
98MP0002332_abnormal_exercise_endurance0.73455929
99MP0003638_abnormal_response/metabolism_0.72920503
100MP0009764_decreased_sensitivity_to0.72487923
101MP0001501_abnormal_sleep_pattern0.68693948
102* MP0001191_abnormal_skin_condition0.67408073
103* MP0002136_abnormal_kidney_physiology0.66635265
104MP0010234_abnormal_vibrissa_follicle0.65821129
105MP0001879_abnormal_lymphatic_vessel0.65098739
106MP0003183_abnormal_peptide_metabolism0.64795467
107MP0003705_abnormal_hypodermis_morpholog0.63891275
108MP0005666_abnormal_adipose_tissue0.60968979
109MP0000490_abnormal_crypts_of0.60933879
110MP0002796_impaired_skin_barrier0.60460402
111MP0001958_emphysema0.59489744
112MP0004130_abnormal_muscle_cell0.59318054
113MP0001502_abnormal_circadian_rhythm0.58712114
114MP0009765_abnormal_xenobiotic_induced0.57751081
115MP0002009_preneoplasia0.57369730
116MP0002132_abnormal_respiratory_system0.57155000
117MP0008873_increased_physiological_sensi0.57131240
118MP0008874_decreased_physiological_sensi0.53958852

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.95627993
2Elevated erythrocyte sedimentation rate (HP:0003565)5.95796500
3Increased density of long bones (HP:0006392)5.18211591
4Myositis (HP:0100614)5.12396930
5Orchitis (HP:0100796)4.87320095
6Retrobulbar optic neuritis (HP:0100654)4.78782574
7Optic neuritis (HP:0100653)4.78782574
8Persistence of primary teeth (HP:0006335)4.48180786
9Abnormality of macrophages (HP:0004311)4.20758181
10Eczematoid dermatitis (HP:0000976)4.07195383
11Nasal polyposis (HP:0100582)3.96515978
12IgM deficiency (HP:0002850)3.93034708
13Abnormality of the nasal mucosa (HP:0000433)3.83443978
14Arterial thrombosis (HP:0004420)3.66775858
15Recurrent fungal infections (HP:0002841)3.48787296
16Keratoconjunctivitis sicca (HP:0001097)3.46440040
17Pulmonary infiltrates (HP:0002113)3.38991327
18Recurrent gram-negative bacterial infections (HP:0005420)3.37994277
19Chronic otitis media (HP:0000389)3.36709873
20Recurrent bronchitis (HP:0002837)3.30629106
21Keratoconjunctivitis (HP:0001096)3.27108995
22Cerebral aneurysm (HP:0004944)3.27017245
23T lymphocytopenia (HP:0005403)3.26507532
24Hemoptysis (HP:0002105)3.17600516
25Abnormality of T cell number (HP:0011839)3.17105692
26Mediastinal lymphadenopathy (HP:0100721)3.14064044
27Vasculitis (HP:0002633)3.10222206
28Gastrointestinal infarctions (HP:0005244)3.05039691
29Dysostosis multiplex (HP:0000943)2.98566451
30Interstitial pulmonary disease (HP:0006530)2.95734473
31Aortic aneurysm (HP:0004942)2.95394976
32Chronic diarrhea (HP:0002028)2.95257554
33IgG deficiency (HP:0004315)2.90982463
34Abnormality of liposaccharide metabolism (HP:0010968)2.90924283
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.90924283
36Abnormality of glycolipid metabolism (HP:0010969)2.90924283
37Abnormality of T cells (HP:0002843)2.89954637
38Chronic obstructive pulmonary disease (HP:0006510)2.87906999
39Obstructive lung disease (HP:0006536)2.87906999
40Spontaneous hematomas (HP:0007420)2.80383694
41Autoimmune hemolytic anemia (HP:0001890)2.78384700
42Hematochezia (HP:0002573)2.77516242
43Increased IgE level (HP:0003212)2.77209437
44Leukocytosis (HP:0001974)2.73327441
45Recurrent abscess formation (HP:0002722)2.72533661
46Aortic dissection (HP:0002647)2.72167458
47Recurrent cutaneous fungal infections (HP:0011370)2.65685899
48Chronic mucocutaneous candidiasis (HP:0002728)2.65685899
49Abnormality of eosinophils (HP:0001879)2.65625286
50Severe combined immunodeficiency (HP:0004430)2.64597883
51Pulmonary embolism (HP:0002204)2.60169854
52Arterial tortuosity (HP:0005116)2.59311474
53Abnormality of T cell physiology (HP:0011840)2.56257606
54Recurrent bacterial skin infections (HP:0005406)2.55631558
55Autoimmune thrombocytopenia (HP:0001973)2.55569333
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.53550174
57Thyroiditis (HP:0100646)2.52838418
58Increased IgM level (HP:0003496)2.52245029
59Inflammation of the large intestine (HP:0002037)2.51656278
60Recurrent viral infections (HP:0004429)2.49611456
61Vascular tortuosity (HP:0004948)2.46190625
62Prolonged bleeding time (HP:0003010)2.45228588
63Amyloidosis (HP:0011034)2.44372461
64IgA deficiency (HP:0002720)2.42760765
65Papilloma (HP:0012740)2.42502284
66Verrucae (HP:0200043)2.42502284
67Joint swelling (HP:0001386)2.40574706
68Urticaria (HP:0001025)2.40391270
69Emphysema (HP:0002097)2.40273662
70Loss of speech (HP:0002371)2.38929207
71Colitis (HP:0002583)2.38806689
72Gastrointestinal inflammation (HP:0004386)2.38052698
73Pustule (HP:0200039)2.36547812
74Granulocytopenia (HP:0001913)2.34321248
75Increased cerebral lipofuscin (HP:0011813)2.30982309
76Combined immunodeficiency (HP:0005387)2.27168196
77Myocardial infarction (HP:0001658)2.26978612
78Dilatation of the ascending aorta (HP:0005111)2.25590210
79Recurrent skin infections (HP:0001581)2.24444897
80Abnormality of polysaccharide metabolism (HP:0011012)2.24168556
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24168556
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24168556
83Gastrointestinal stroma tumor (HP:0100723)2.23890045
84Gingivitis (HP:0000230)2.21922716
85Chest pain (HP:0100749)2.21585788
86Meningitis (HP:0001287)2.20903948
87Striae distensae (HP:0001065)2.20757277
88Increased serum ferritin (HP:0003281)2.20637162
89Episodic fever (HP:0001954)2.18500839
90Mitral valve prolapse (HP:0001634)2.18233829
91Urinary glycosaminoglycan excretion (HP:0003541)2.17634607
92Mucopolysacchariduria (HP:0008155)2.17634607
93Depressed nasal tip (HP:0000437)2.16902607
94Agammaglobulinemia (HP:0004432)2.14541350
95Hypergammaglobulinemia (HP:0010702)2.12851991
96Systemic lupus erythematosus (HP:0002725)2.12392893
97Restrictive lung disease (HP:0002091)2.11060362
98Eosinophilia (HP:0001880)2.10698007
99Premature loss of primary teeth (HP:0006323)2.08514531
100Slow saccadic eye movements (HP:0000514)2.05711119
101Abnormality of the pericardium (HP:0001697)2.05518726
102Malnutrition (HP:0004395)2.05479656
103Epistaxis (HP:0000421)2.05146139
104Gangrene (HP:0100758)2.05109613
105Segmental peripheral demyelination/remyelination (HP:0003481)2.04693917
106Fatigue (HP:0012378)2.04263702
107Abnormality of the pleura (HP:0002103)2.01729989
108Anorexia (HP:0002039)2.01546994
109Vacuolated lymphocytes (HP:0001922)2.00658448
110Osteomyelitis (HP:0002754)1.99967033
111Glomerulopathy (HP:0100820)1.97945079
112Lymphopenia (HP:0001888)1.97352458
113Polycythemia (HP:0001901)1.97131709
114Peritonitis (HP:0002586)1.96695881
115Abnormality of the prostate (HP:0008775)1.96492262
116Panhypogammaglobulinemia (HP:0003139)1.96007957
117Cellulitis (HP:0100658)1.95606479
118Thrombocytosis (HP:0001894)1.95413036
119Obstructive sleep apnea (HP:0002870)1.95045896
120Thrombophlebitis (HP:0004418)1.94289410
121Increased neuronal autofluorescent lipopigment (HP:0002074)1.90751433
122Disproportionate tall stature (HP:0001519)1.90091075
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.88986106
124Arthralgia (HP:0002829)1.86969197
125Recurrent sinusitis (HP:0011108)1.85051040
126Sepsis (HP:0100806)1.84948282
127Abnormality of the fingertips (HP:0001211)1.84878487
128Hepatitis (HP:0012115)1.84136124
129Impaired platelet aggregation (HP:0003540)1.83917908
130Abnormal platelet function (HP:0011869)1.83917908
131Abnormality of B cell number (HP:0010975)1.82654315
132B lymphocytopenia (HP:0010976)1.82654315
133Spondylolisthesis (HP:0003302)1.82131526
134Encephalitis (HP:0002383)1.81869127
135Acrocyanosis (HP:0001063)1.80510429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.77602415
2MAPK153.56771831
3TXK3.56593665
4MAP3K143.52849646
5PRPF4B3.31941293
6ITK3.29077783
7TGFBR22.81324334
8TSSK62.68656375
9TBK12.53467207
10IRAK32.52773303
11JAK32.47119065
12TYK22.45498863
13EPHB12.31552322
14JAK12.28664863
15TAOK32.22961260
16IKBKE2.20173550
17STK102.18517797
18IKBKB2.17040108
19EPHA32.11227205
20FGFR42.00059017
21TEC1.92378047
22GRK61.76297588
23MAP3K131.73784935
24CHUK1.71427805
25ZAP701.67629803
26ERN11.66581373
27NLK1.63365281
28BTK1.50622061
29MAP2K21.48746376
30MAP3K101.44915117
31TAOK21.43453639
32HCK1.39061186
33TNK21.28407031
34JAK21.28126801
35PTK61.27490101
36CSK1.26975455
37LCK1.22197090
38TRIB31.16021829
39MAP2K31.15511918
40MST41.13796436
41FGFR31.13591468
42RPS6KA41.12417197
43PIM11.06598993
44TESK21.03680760
45MARK30.97666876
46CDC42BPA0.96373781
47MARK20.93683722
48MAP3K30.92864949
49BMPR20.92831617
50KDR0.91241159
51PKN20.91219012
52EEF2K0.90021215
53FES0.88187179
54RIPK10.87271181
55IRAK20.86310129
56CAMKK10.82428730
57IRAK40.82037157
58MAPK70.81887062
59IRAK10.81587427
60GSK3A0.80331732
61SYK0.80246427
62RPS6KC10.79618656
63RPS6KL10.79618656
64LRRK20.75662592
65PRKD20.74874358
66FGR0.74131201
67GRK70.72756402
68BLK0.71785111
69KIT0.71411035
70PRKCH0.70881723
71HIPK20.70239037
72SIK30.68374283
73CAMKK20.66195363
74MOS0.65360776
75CSF1R0.60998121
76TTN0.60508952
77PDGFRB0.58529774
78MATK0.58518313
79PASK0.58217526
80SMG10.58075839
81RPS6KA50.57713061
82RPS6KA20.56849095
83MAPKAPK50.54136652
84MAP3K10.53473165
85RPS6KA10.53451255
86PRKCQ0.53004396
87PDPK10.52885756
88MAPK40.52087207
89MAPK110.52037995
90RIPK40.50927095
91PKN10.49053484
92TAOK10.48996455
93PIM20.48442706
94MAP3K70.48184582
95CLK10.48184006
96SIK10.48049166
97MAP3K60.47364938
98SIK20.43552770
99MELK0.43466930
100TYRO30.41925313
101MAPKAPK20.41855184
102RPS6KA60.41726289
103RET0.41019856
104LYN0.40903409
105ICK0.40355582
106PTK20.38767560
107FYN0.38380768
108INSR0.38137237
109CDK40.37460257
110MAPK120.37325299
111TRPM70.37215375
112IGF1R0.36987286
113DYRK1B0.36745544
114PTK2B0.35937531
115PAK20.35458223
116MAP3K110.34805571
117MAP3K20.34590877
118VRK10.33904354
119TIE10.32835052
120DMPK0.32459848
121CDK120.32017990
122MAP2K60.32008607
123TGFBR10.31686143
124PAK40.31383515
125ALK0.30790454
126CDK60.30102753
127PDK10.29071170
128STK110.28632548
129* MAPK30.26889116

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.40210643
2* Osteoclast differentiation_Homo sapiens_hsa043803.02010813
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.93985396
4T cell receptor signaling pathway_Homo sapiens_hsa046602.80717113
5Primary immunodeficiency_Homo sapiens_hsa053402.72619644
6Leishmaniasis_Homo sapiens_hsa051402.64763295
7Measles_Homo sapiens_hsa051622.36871551
8B cell receptor signaling pathway_Homo sapiens_hsa046622.26064139
9* TNF signaling pathway_Homo sapiens_hsa046682.21515294
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.21408149
11Antigen processing and presentation_Homo sapiens_hsa046122.17623765
12Toxoplasmosis_Homo sapiens_hsa051452.05946392
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89588190
14Legionellosis_Homo sapiens_hsa051341.75433026
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.70677111
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65884624
17Acute myeloid leukemia_Homo sapiens_hsa052211.57433787
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54945342
19Allograft rejection_Homo sapiens_hsa053301.54115656
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50144382
21Prolactin signaling pathway_Homo sapiens_hsa049171.47552147
22Influenza A_Homo sapiens_hsa051641.45606454
23Hepatitis B_Homo sapiens_hsa051611.44214289
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42326294
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.40023385
26Chronic myeloid leukemia_Homo sapiens_hsa052201.37999314
27Apoptosis_Homo sapiens_hsa042101.37335501
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34745291
29Chemokine signaling pathway_Homo sapiens_hsa040621.32889178
30Malaria_Homo sapiens_hsa051441.28501713
31Staphylococcus aureus infection_Homo sapiens_hsa051501.25596264
32Pertussis_Homo sapiens_hsa051331.25278841
33Herpes simplex infection_Homo sapiens_hsa051681.25261142
34Shigellosis_Homo sapiens_hsa051311.23743218
35Graft-versus-host disease_Homo sapiens_hsa053321.21089483
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19440619
37Rheumatoid arthritis_Homo sapiens_hsa053231.18139981
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17181207
39Hematopoietic cell lineage_Homo sapiens_hsa046401.14306533
40Viral myocarditis_Homo sapiens_hsa054161.11269716
41Pancreatic cancer_Homo sapiens_hsa052121.06203953
42HTLV-I infection_Homo sapiens_hsa051661.05147615
43MAPK signaling pathway_Homo sapiens_hsa040101.04637041
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.03935925
45Salmonella infection_Homo sapiens_hsa051321.03478440
46Circadian rhythm_Homo sapiens_hsa047101.01818004
47Colorectal cancer_Homo sapiens_hsa052101.01326551
48Prion diseases_Homo sapiens_hsa050201.00818656
49Tuberculosis_Homo sapiens_hsa051521.00013108
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99266586
51Small cell lung cancer_Homo sapiens_hsa052220.98047401
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.97935960
53VEGF signaling pathway_Homo sapiens_hsa043700.97317967
54Epstein-Barr virus infection_Homo sapiens_hsa051690.97195001
55Platelet activation_Homo sapiens_hsa046110.96776797
56Hepatitis C_Homo sapiens_hsa051600.88573004
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88286795
58Autoimmune thyroid disease_Homo sapiens_hsa053200.87855406
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86133490
60Renal cell carcinoma_Homo sapiens_hsa052110.81205907
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80394205
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78035750
63Estrogen signaling pathway_Homo sapiens_hsa049150.77741931
64Dorso-ventral axis formation_Homo sapiens_hsa043200.76968543
65Endocytosis_Homo sapiens_hsa041440.76704191
66Phagosome_Homo sapiens_hsa041450.75906447
67Asthma_Homo sapiens_hsa053100.74476303
68Notch signaling pathway_Homo sapiens_hsa043300.72386937
69Insulin resistance_Homo sapiens_hsa049310.72228613
70Viral carcinogenesis_Homo sapiens_hsa052030.70507440
71FoxO signaling pathway_Homo sapiens_hsa040680.68962345
72Type II diabetes mellitus_Homo sapiens_hsa049300.66442537
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65356794
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64280717
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64087866
76GnRH signaling pathway_Homo sapiens_hsa049120.62621913
77Amoebiasis_Homo sapiens_hsa051460.62042728
78Focal adhesion_Homo sapiens_hsa045100.60729661
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57131480
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56690987
81mTOR signaling pathway_Homo sapiens_hsa041500.56520280
82Type I diabetes mellitus_Homo sapiens_hsa049400.54098438
83Proteoglycans in cancer_Homo sapiens_hsa052050.52180860
84HIF-1 signaling pathway_Homo sapiens_hsa040660.51326914
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49908623
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.49762171
87Pathways in cancer_Homo sapiens_hsa052000.48619597
88Prostate cancer_Homo sapiens_hsa052150.48161370
89African trypanosomiasis_Homo sapiens_hsa051430.48087959
90Bladder cancer_Homo sapiens_hsa052190.47940731
91Other glycan degradation_Homo sapiens_hsa005110.47841462
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47242312
93Lysosome_Homo sapiens_hsa041420.46966669
94Inositol phosphate metabolism_Homo sapiens_hsa005620.46449613
95Endometrial cancer_Homo sapiens_hsa052130.46127045
96Systemic lupus erythematosus_Homo sapiens_hsa053220.45967880
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.45426291
98Non-small cell lung cancer_Homo sapiens_hsa052230.45216556
99ErbB signaling pathway_Homo sapiens_hsa040120.43662280
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42270495
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42009240
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39722488
103Choline metabolism in cancer_Homo sapiens_hsa052310.38922653
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38174902
105Rap1 signaling pathway_Homo sapiens_hsa040150.37767060
106MicroRNAs in cancer_Homo sapiens_hsa052060.37451144
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37151861
108Adherens junction_Homo sapiens_hsa045200.37054405
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36717729
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35560226
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.34392378
112Complement and coagulation cascades_Homo sapiens_hsa046100.33804464
113Insulin signaling pathway_Homo sapiens_hsa049100.31068587

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