JUN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)6.18509067
2regulation of chemokine secretion (GO:0090196)5.41076385
3heart valve formation (GO:0003188)5.29184187
4neuronal stem cell maintenance (GO:0097150)4.86510852
5neuron fate determination (GO:0048664)4.40510181
6negative regulation of oligodendrocyte differentiation (GO:0048715)4.31432250
7endocardial cushion morphogenesis (GO:0003203)4.29124385
8endothelial cell chemotaxis (GO:0035767)4.25358758
9negative regulation of glial cell proliferation (GO:0060253)4.07713701
10positive regulation of extracellular matrix organization (GO:1903055)3.98913435
11negative regulation of inclusion body assembly (GO:0090084)3.83956488
12neural crest cell development (GO:0014032)3.77545856
13mesenchyme morphogenesis (GO:0072132)3.71644487
14mesenchymal cell development (GO:0014031)3.65965075
15stem cell development (GO:0048864)3.65260490
16negative regulation of granulocyte differentiation (GO:0030853)3.62197691
17labyrinthine layer blood vessel development (GO:0060716)3.57669542
18ventricular septum morphogenesis (GO:0060412)3.53438815
19negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.53232178
20regulation of cell proliferation involved in kidney development (GO:1901722)3.49196381
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.47415681
22Notch signaling involved in heart development (GO:0061314)3.45378039
23regulation of inclusion body assembly (GO:0090083)3.44142682
24pattern specification involved in kidney development (GO:0061004)3.43046078
25otic vesicle formation (GO:0030916)3.39001488
26* microglial cell activation (GO:0001774)3.38811510
27germ cell migration (GO:0008354)3.36745986
28response to laminar fluid shear stress (GO:0034616)3.35284796
29response to muramyl dipeptide (GO:0032495)3.32700253
30establishment of nucleus localization (GO:0040023)3.26855614
31hemidesmosome assembly (GO:0031581)3.24264235
32regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.18958623
33positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.18958623
34cell proliferation involved in metanephros development (GO:0072203)3.17143792
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16181402
36positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.14275338
37central nervous system myelination (GO:0022010)3.12319522
38axon ensheathment in central nervous system (GO:0032291)3.12319522
39positive regulation of Notch signaling pathway (GO:0045747)3.12312350
40pathway-restricted SMAD protein phosphorylation (GO:0060389)3.10967755
41heart valve morphogenesis (GO:0003179)3.09094907
42macrophage activation involved in immune response (GO:0002281)3.07854804
43placenta blood vessel development (GO:0060674)3.06813092
44positive regulation of glomerulus development (GO:0090193)3.05646070
45regulation of mesenchymal cell apoptotic process (GO:2001053)3.03741358
46adhesion of symbiont to host cell (GO:0044650)2.99382610
47virion attachment to host cell (GO:0019062)2.99382610
48regulation of p38MAPK cascade (GO:1900744)2.98048525
49regulation of interferon-beta biosynthetic process (GO:0045357)2.95123334
50regulation of secondary heart field cardioblast proliferation (GO:0003266)2.91399744
51regulation of cardioblast proliferation (GO:0003264)2.91399744
52negative regulation of erythrocyte differentiation (GO:0045647)2.88877636
53response to progesterone (GO:0032570)2.86502025
54cell proliferation involved in kidney development (GO:0072111)2.86254396
55cell-cell signaling involved in cell fate commitment (GO:0045168)2.84057484
56limb bud formation (GO:0060174)2.83936951
57negative regulation of bone resorption (GO:0045779)2.82936550
58regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.82850846
59positive regulation by symbiont of host defense response (GO:0052509)2.82579781
60modulation by symbiont of host defense response (GO:0052031)2.82579781
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82579781
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82579781
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.82579781
64modulation by symbiont of host immune response (GO:0052553)2.82579781
65cell morphogenesis involved in neuron differentiation (GO:0048667)2.81725314
66positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.81005228
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.81005228
68astrocyte differentiation (GO:0048708)2.79856977
69nephron epithelium morphogenesis (GO:0072088)2.79616035
70nephron tubule morphogenesis (GO:0072078)2.79616035
71response to mineralocorticoid (GO:0051385)2.78285816
72interleukin-1-mediated signaling pathway (GO:0070498)2.77954267
73negative regulation of myoblast differentiation (GO:0045662)2.76813785
74positive regulation of male gonad development (GO:2000020)2.73932697
75regulation of heart morphogenesis (GO:2000826)2.71230036
76tolerance induction (GO:0002507)2.70354873
77purinergic nucleotide receptor signaling pathway (GO:0035590)2.69536941
78protein refolding (GO:0042026)2.69036408
79ventricular septum development (GO:0003281)2.68541183
80RNA destabilization (GO:0050779)2.67487245
81negative regulation of gluconeogenesis (GO:0045721)2.67391894
82skeletal muscle cell differentiation (GO:0035914)2.66891317
83dermatan sulfate metabolic process (GO:0030205)2.65316228
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64384082
85oligodendrocyte differentiation (GO:0048709)2.62534484
86cell migration involved in sprouting angiogenesis (GO:0002042)2.62530744
87response to fluid shear stress (GO:0034405)2.61480324
88regulation of extracellular matrix organization (GO:1903053)2.60462174
89cellular response to fluid shear stress (GO:0071498)2.59161275
90lymph vessel development (GO:0001945)2.58871754
91platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58552714
92potassium ion export (GO:0071435)2.57610584
93positive regulation of astrocyte differentiation (GO:0048711)2.57358864
94osteoblast development (GO:0002076)2.56358079
95macrophage differentiation (GO:0030225)2.56356129
96endothelial cell differentiation (GO:0045446)2.55409582
97photoreceptor cell differentiation (GO:0046530)2.55101638
98eye photoreceptor cell differentiation (GO:0001754)2.55101638
99tongue development (GO:0043586)2.54876200
100chondroitin sulfate catabolic process (GO:0030207)2.54317276
101oligosaccharide catabolic process (GO:0009313)2.53982639
102negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.53113175
103adhesion of symbiont to host (GO:0044406)2.52849916
104dermatan sulfate biosynthetic process (GO:0030208)2.51985074
105antigen processing and presentation of endogenous antigen (GO:0019883)2.50029305
106notochord development (GO:0030903)2.49301551
107definitive hemopoiesis (GO:0060216)2.48961027
108endothelium development (GO:0003158)2.48862933
109regulation of glomerulus development (GO:0090192)2.48307088
110nephron tubule formation (GO:0072079)2.48255410
111negative regulation of bone remodeling (GO:0046851)2.48202245
112forebrain neuron differentiation (GO:0021879)2.46910287
113negative regulation of tissue remodeling (GO:0034104)2.46723574
114response to gravity (GO:0009629)2.46543238
115regulation of timing of cell differentiation (GO:0048505)2.45813515
116keratan sulfate catabolic process (GO:0042340)2.43762179
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43742659
118positive regulation of p38MAPK cascade (GO:1900745)2.43631572
119branching involved in labyrinthine layer morphogenesis (GO:0060670)2.43069505
120regulation of synapse structural plasticity (GO:0051823)2.42953311
121telencephalon development (GO:0021537)2.42207305
122regulation of astrocyte differentiation (GO:0048710)2.39440661
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38801152
124glial cell differentiation (GO:0010001)2.38054829
125positive regulation of mRNA catabolic process (GO:0061014)2.37647612
126cochlea morphogenesis (GO:0090103)2.37127990
127gland morphogenesis (GO:0022612)2.36866297
128cellular response to antibiotic (GO:0071236)2.36640570
129cochlea development (GO:0090102)2.36330425
130mRNA transcription from RNA polymerase II promoter (GO:0042789)2.36136203
131sodium-independent organic anion transport (GO:0043252)2.36038309
132embryonic process involved in female pregnancy (GO:0060136)2.35703009
133cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35222132
134positive regulation of BMP signaling pathway (GO:0030513)2.34329069
135midbrain development (GO:0030901)2.33496904
136ventricular trabecula myocardium morphogenesis (GO:0003222)2.33496836
137lung lobe morphogenesis (GO:0060463)2.32970660
138activation of MAPKKK activity (GO:0000185)2.32856504
139positive regulation of metanephros development (GO:0072216)2.32709562
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.32055270
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.31185229
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31185229
143negative regulation of glial cell differentiation (GO:0045686)2.31157448
144somatic stem cell maintenance (GO:0035019)2.30258122
145G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.30194647
146surfactant homeostasis (GO:0043129)2.29960041
147lens fiber cell development (GO:0070307)2.28998351
148heart trabecula morphogenesis (GO:0061384)2.28933390
149negative regulation of interleukin-6 production (GO:0032715)2.28594855
150epithelial tube branching involved in lung morphogenesis (GO:0060441)2.28377674
151glomerular filtration (GO:0003094)2.27005398
152glycosphingolipid catabolic process (GO:0046479)2.25841055
153regulation of glial cell proliferation (GO:0060251)2.25420384
154artery morphogenesis (GO:0048844)2.25079312
155radial glial cell differentiation (GO:0060019)2.24953987
156atrioventricular valve morphogenesis (GO:0003181)2.24369972
157mitotic cell cycle arrest (GO:0071850)2.22011419
158glycolipid catabolic process (GO:0019377)2.21297548
159* monocyte differentiation (GO:0030224)2.20761347
160regulation of somitogenesis (GO:0014807)2.20242390
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18785490
162mature B cell differentiation (GO:0002335)2.18262304
163cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.17078102
164vascular endothelial growth factor signaling pathway (GO:0038084)2.16912784
165ruffle organization (GO:0031529)2.16761646
166regulation of mRNA catabolic process (GO:0061013)2.15760307
167positive thymic T cell selection (GO:0045059)2.15410521
168regulation of bone resorption (GO:0045124)2.15387630
169ceramide catabolic process (GO:0046514)2.13222591
170regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.13014358
171negative regulation of translation, ncRNA-mediated (GO:0040033)2.12652033
172regulation of translation, ncRNA-mediated (GO:0045974)2.12652033
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12652033
174purinergic receptor signaling pathway (GO:0035587)2.10853165
175endoderm formation (GO:0001706)2.10723586
176* macrophage activation (GO:0042116)2.09973273
177outer ear morphogenesis (GO:0042473)2.09684933
178blood vessel maturation (GO:0001955)2.08904099
179response to lipoprotein particle (GO:0055094)2.08364956
180response to corticosterone (GO:0051412)2.07669058
181response to cholesterol (GO:0070723)2.07666779
182response to sterol (GO:0036314)2.07559209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.80648183
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50225089
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.75160607
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69589957
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62420608
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.47361351
7SCL_19346495_ChIP-Seq_HPC-7_Human2.46732203
8EZH2_22144423_ChIP-Seq_EOC_Human2.46336778
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.31758664
10* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20106603
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.15008628
12RUNX_20019798_ChIP-Seq_JUKART_Human2.12878462
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08183644
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08147033
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07846460
16* EGR1_19374776_ChIP-ChIP_THP-1_Human2.07826089
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.06834121
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.06528459
19* RNF2_27304074_Chip-Seq_ESCs_Mouse1.99510454
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98333887
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98333887
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98333887
23CLOCK_20551151_ChIP-Seq_293T_Human1.94472423
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88922207
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.87270607
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.87058850
27* WT1_19549856_ChIP-ChIP_CCG9911_Human1.86146171
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.85553129
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83977777
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83243675
31* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83075374
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.76011904
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.75889073
34* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72584811
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68057601
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67362533
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.67095340
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62080493
39* RING1B_27294783_Chip-Seq_NPCs_Mouse1.58473688
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54064188
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54026478
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53526262
43VDR_24787735_ChIP-Seq_THP-1_Human1.53400051
44* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53142228
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52960342
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50616283
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50191729
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47911190
49TCF7_22412390_ChIP-Seq_EML_Mouse1.45351861
50* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42747174
51* CJUN_26792858_Chip-Seq_BT549_Human1.42526119
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41714936
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41125208
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38696911
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38640160
56DROSHA_22980978_ChIP-Seq_HELA_Human1.38083193
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.37805366
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37479326
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36926967
60* CDX2_20551321_ChIP-Seq_CACO-2_Human1.32627494
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31731162
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.31598038
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30704938
64VDR_24763502_ChIP-Seq_THP-1_Human1.30586382
65GATA1_22025678_ChIP-Seq_K562_Human1.29218357
66AHR_22903824_ChIP-Seq_MCF-7_Human1.27724978
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25875596
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24067535
69* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22063369
70GATA1_19941826_ChIP-Seq_K562_Human1.20880117
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18460054
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18457975
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17781523
74* SOX2_20726797_ChIP-Seq_SW620_Human1.16893438
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16810008
76* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15014948
77* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12264900
78* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11669322
79TP53_16413492_ChIP-PET_HCT116_Human1.11233816
80* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09258999
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.08594202
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08339339
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08247135
84* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07943164
85* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07222367
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.06816464
87LXR_22292898_ChIP-Seq_THP-1_Human1.06718457
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05504333
89* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05425813
90* KDM2B_26808549_Chip-Seq_DND41_Human1.05142817
91* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05092799
92* GATA2_19941826_ChIP-Seq_K562_Human1.05007841
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04604558
94* KDM2B_26808549_Chip-Seq_K562_Human1.03816963
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.03665899
96RXR_22108803_ChIP-Seq_LS180_Human1.03589012
97* ISL1_27105846_Chip-Seq_CPCs_Mouse1.02372446
98* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02064379
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01930523
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01289336
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01237065
102SPI1_23127762_ChIP-Seq_K562_Human1.01124216
103* ARNT_22903824_ChIP-Seq_MCF-7_Human1.01081795
104* AR_21572438_ChIP-Seq_LNCaP_Human1.00945123
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00839374
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00839374
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99695018
108* MAF_26560356_Chip-Seq_TH1_Human0.98958100
109* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97905061
110* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97854817
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97733163
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97720430
113RNF2_27304074_Chip-Seq_NSC_Mouse0.97148549
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97020225
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96561963
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96195941
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96121737
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96008116
119VDR_21846776_ChIP-Seq_THP-1_Human0.95903605
120* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95346733
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94337561
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94134912
123SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94096691
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93822368
125* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93441704
126* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93441704
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93236054
128TP53_18474530_ChIP-ChIP_U2OS_Human0.92684035
129* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92613983
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90700324
131* EED_16625203_ChIP-ChIP_MESCs_Mouse0.90685801
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90646380
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89875189
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87317325
135* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86621628
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86037252
137* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85466948
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84715365
139* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84345117
140* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82822638
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.82738113
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82246831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.83863306
2MP0003724_increased_susceptibility_to4.42370668
3MP0002254_reproductive_system_inflammat3.26287428
4MP0002249_abnormal_larynx_morphology3.20110098
5MP0002653_abnormal_ependyma_morphology3.13814124
6MP0003303_peritoneal_inflammation2.69189718
7MP0005503_abnormal_tendon_morphology2.49771288
8MP0009278_abnormal_bone_marrow2.48344787
9MP0003300_gastrointestinal_ulcer2.37773952
10MP0003828_pulmonary_edema2.37211097
11MP0008004_abnormal_stomach_pH2.33975172
12MP0006082_CNS_inflammation2.31235062
13MP0010368_abnormal_lymphatic_system2.01740717
14MP0003191_abnormal_cellular_cholesterol2.01640404
15* MP0002928_abnormal_bile_duct2.00843546
16* MP0001851_eye_inflammation2.00433438
17MP0001502_abnormal_circadian_rhythm1.98856554
18MP0005084_abnormal_gallbladder_morpholo1.96930855
19MP0006138_congestive_heart_failure1.95018753
20MP0004272_abnormal_basement_membrane1.90862873
21MP0002282_abnormal_trachea_morphology1.85767282
22MP0003283_abnormal_digestive_organ1.85281340
23MP0005671_abnormal_response_to1.84500022
24MP0001879_abnormal_lymphatic_vessel1.78063780
25MP0003279_aneurysm1.75627429
26MP0000465_gastrointestinal_hemorrhage1.69648625
27MP0002277_abnormal_respiratory_mucosa1.65207054
28MP0002009_preneoplasia1.65006468
29MP0009053_abnormal_anal_canal1.64916335
30MP0003075_altered_response_to1.63502751
31MP0001835_abnormal_antigen_presentation1.62565422
32MP0001533_abnormal_skeleton_physiology1.60902723
33MP0000685_abnormal_immune_system1.60624937
34MP0003045_fibrosis1.58152189
35MP0001873_stomach_inflammation1.57343885
36MP0000383_abnormal_hair_follicle1.55061387
37MP0002419_abnormal_innate_immunity1.54533074
38MP0002405_respiratory_system_inflammati1.54517087
39MP0009384_cardiac_valve_regurgitation1.52975287
40MP0003566_abnormal_cell_adhesion1.51512330
41MP0003690_abnormal_glial_cell1.51405080
42MP0000767_abnormal_smooth_muscle1.47989344
43MP0002822_catalepsy1.47473289
44MP0001790_abnormal_immune_system1.46948821
45MP0005387_immune_system_phenotype1.46948821
46MP0002452_abnormal_antigen_presenting1.46089737
47MP0000534_abnormal_ureter_morphology1.45176513
48MP0000778_abnormal_nervous_system1.44041274
49MP0002998_abnormal_bone_remodeling1.42990446
50MP0001853_heart_inflammation1.42827505
51MP0002723_abnormal_immune_serum1.42261102
52MP0005000_abnormal_immune_tolerance1.41281918
53MP0010678_abnormal_skin_adnexa1.41150270
54MP0008961_abnormal_basal_metabolism1.40856636
55MP0001800_abnormal_humoral_immune1.39446332
56MP0005595_abnormal_vascular_smooth1.38316882
57MP0004947_skin_inflammation1.36298490
58MP0002166_altered_tumor_susceptibility1.35931096
59MP0000026_abnormal_inner_ear1.34650291
60MP0004883_abnormal_blood_vessel1.33408571
61MP0001958_emphysema1.33398190
62MP0000343_altered_response_to1.31758200
63MP0004510_myositis1.31284810
64MP0009250_abnormal_appendicular_skeleto1.29211512
65MP0002060_abnormal_skin_morphology1.27320517
66MP0008438_abnormal_cutaneous_collagen1.26748796
67MP0002933_joint_inflammation1.24462899
68MP0004885_abnormal_endolymph1.24058617
69MP0005390_skeleton_phenotype1.19837178
70MP0005464_abnormal_platelet_physiology1.19478198
71MP0005508_abnormal_skeleton_morphology1.18945468
72MP0002420_abnormal_adaptive_immunity1.18821316
73MP0001819_abnormal_immune_cell1.18706510
74MP0010155_abnormal_intestine_physiology1.17988697
75MP0001270_distended_abdomen1.17219519
76MP0009840_abnormal_foam_cell1.16591656
77* MP0003453_abnormal_keratinocyte_physiol1.15444111
78MP0005397_hematopoietic_system_phenotyp1.15179457
79MP0001545_abnormal_hematopoietic_system1.15179457
80MP0002148_abnormal_hypersensitivity_rea1.14817204
81MP0003705_abnormal_hypodermis_morpholog1.14746989
82MP0003091_abnormal_cell_migration1.13146001
83MP0001542_abnormal_bone_strength1.12300339
84MP0000537_abnormal_urethra_morphology1.11656176
85MP0005388_respiratory_system_phenotype1.10231649
86MP0005409_darkened_coat_color1.10018002
87MP0001346_abnormal_lacrimal_gland1.09871895
88MP0005623_abnormal_meninges_morphology1.09400980
89MP0000631_abnormal_neuroendocrine_gland1.08799365
90MP0003172_abnormal_lysosome_physiology1.08269867
91MP0005058_abnormal_lysosome_morphology1.08218261
92MP0002116_abnormal_craniofacial_bone1.05002801
93MP0004808_abnormal_hematopoietic_stem1.04279432
94MP0000467_abnormal_esophagus_morphology1.03718998
95MP0005167_abnormal_blood-brain_barrier1.03088227
96MP0005165_increased_susceptibility_to1.02574471
97MP0001485_abnormal_pinna_reflex1.01124178
98MP0005164_abnormal_response_to0.99663502
99MP0005666_abnormal_adipose_tissue0.98970575
100MP0003634_abnormal_glial_cell0.98924771
101MP0001845_abnormal_inflammatory_respons0.98132621
102MP0008007_abnormal_cellular_replicative0.97754631
103MP0004185_abnormal_adipocyte_glucose0.97651314
104MP0009379_abnormal_foot_pigmentation0.97441526
105MP0005025_abnormal_response_to0.95908391
106MP0003866_abnormal_defecation0.95642272
107MP0002638_abnormal_pupillary_reflex0.93748295
108MP0003436_decreased_susceptibility_to0.93029248
109MP0005171_absent_coat_pigmentation0.92805663
110MP0000733_abnormal_muscle_development0.92759417
111MP0005377_hearing/vestibular/ear_phenot0.92628110
112MP0003878_abnormal_ear_physiology0.92628110
113MP0004381_abnormal_hair_follicle0.92326951
114MP0008995_early_reproductive_senescence0.92290637
115MP0000516_abnormal_urinary_system0.92209009
116MP0005367_renal/urinary_system_phenotyp0.92209009
117MP0003183_abnormal_peptide_metabolism0.91612939
118MP0004742_abnormal_vestibular_system0.90933640
119MP0005166_decreased_susceptibility_to0.90120299
120MP0003795_abnormal_bone_structure0.90102190
121MP0002138_abnormal_hepatobiliary_system0.90007456
122* MP0000249_abnormal_blood_vessel0.89673457
123MP0002896_abnormal_bone_mineralization0.89565642
124MP0006054_spinal_hemorrhage0.89348447
125MP0000049_abnormal_middle_ear0.89153547
126MP0002098_abnormal_vibrissa_morphology0.88086985
127MP0001501_abnormal_sleep_pattern0.87271465
128MP0003763_abnormal_thymus_physiology0.87024094
129MP0005076_abnormal_cell_differentiation0.85943052
130MP0002396_abnormal_hematopoietic_system0.85831903
131MP0005275_abnormal_skin_tensile0.85801382
132MP0000762_abnormal_tongue_morphology0.83630886
133MP0003638_abnormal_response/metabolism_0.83395954
134MP0000920_abnormal_myelination0.83212260
135* MP0002925_abnormal_cardiovascular_devel0.81244591
136MP0004782_abnormal_surfactant_physiolog0.81156150
137MP0005646_abnormal_pituitary_gland0.81075241
138MP0005423_abnormal_somatic_nervous0.80806952
139* MP0001216_abnormal_epidermal_layer0.80593320
140MP0000716_abnormal_immune_system0.80408952
141MP0000566_synostosis0.80308028
142MP0002295_abnormal_pulmonary_circulatio0.80304488
143* MP0001614_abnormal_blood_vessel0.79573187
144MP0002133_abnormal_respiratory_system0.79466346
145MP0002108_abnormal_muscle_morphology0.79308779
146MP0005187_abnormal_penis_morphology0.77988803
147MP0003115_abnormal_respiratory_system0.77631351
148MP0000163_abnormal_cartilage_morphology0.76359213
149MP0003755_abnormal_palate_morphology0.75192008
150MP0005375_adipose_tissue_phenotype0.72611297
151MP0000428_abnormal_craniofacial_morphol0.72210445
152MP0002572_abnormal_emotion/affect_behav0.68029523

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)4.88516688
2Glomerulonephritis (HP:0000099)4.65524166
3Cerebral aneurysm (HP:0004944)4.63648470
4Systemic lupus erythematosus (HP:0002725)4.62806156
5Neonatal short-limb short stature (HP:0008921)4.45874540
6Vascular tortuosity (HP:0004948)4.45710269
7Bronchomalacia (HP:0002780)4.00251964
8Broad face (HP:0000283)3.97048534
9Hematochezia (HP:0002573)3.78113401
10Aortic aneurysm (HP:0004942)3.74777582
11Abnormality of liposaccharide metabolism (HP:0010968)3.73632729
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.73632729
13Abnormality of glycolipid metabolism (HP:0010969)3.73632729
14Supernumerary ribs (HP:0005815)3.53160613
15Aortic dissection (HP:0002647)3.38452654
16Milia (HP:0001056)3.35115411
1711 pairs of ribs (HP:0000878)3.32742880
18Atrophic scars (HP:0001075)3.23285157
19Disproportionate tall stature (HP:0001519)3.20276716
20Supernumerary bones of the axial skeleton (HP:0009144)3.17647235
21Mutism (HP:0002300)3.12036191
22Colitis (HP:0002583)3.10042094
23Abnormality of the 4th metacarpal (HP:0010012)3.04517976
24Bone cyst (HP:0012062)3.02670714
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02231302
26Short 4th metacarpal (HP:0010044)3.02231302
27Interstitial pulmonary disease (HP:0006530)2.96413089
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.96385144
29Missing ribs (HP:0000921)2.90547875
30Vertebral hypoplasia (HP:0008417)2.85568031
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85568031
32Neoplasm of the heart (HP:0100544)2.84867627
33Stomach cancer (HP:0012126)2.76340821
34Fibular hypoplasia (HP:0003038)2.73410632
35Dysostosis multiplex (HP:0000943)2.72802984
36Thin ribs (HP:0000883)2.67106262
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.66662103
38Sex reversal (HP:0012245)2.63675734
39Abnormal sex determination (HP:0012244)2.63675734
40Inflammation of the large intestine (HP:0002037)2.63672603
41Increased cerebral lipofuscin (HP:0011813)2.62690832
42Nephritis (HP:0000123)2.59789622
43Arnold-Chiari malformation (HP:0002308)2.54503837
44Abnormality of the diencephalon (HP:0010662)2.53103237
45Complement deficiency (HP:0004431)2.51519094
46Difficulty climbing stairs (HP:0003551)2.50533781
47Retinal atrophy (HP:0001105)2.47482784
48Wide anterior fontanel (HP:0000260)2.44579368
49Abnormality of the nasal mucosa (HP:0000433)2.44246186
50Ulnar claw (HP:0001178)2.42572506
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40522505
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.38612857
53Urethral obstruction (HP:0000796)2.37923039
54Striae distensae (HP:0001065)2.37706686
55Rhinitis (HP:0012384)2.35670845
56Tracheomalacia (HP:0002779)2.34840301
57Gastrointestinal inflammation (HP:0004386)2.33612218
58Premature skin wrinkling (HP:0100678)2.31732769
59Abnormality of the parietal bone (HP:0002696)2.31068344
60Broad metatarsal (HP:0001783)2.29690448
61Eczematoid dermatitis (HP:0000976)2.27581517
62Spontaneous hematomas (HP:0007420)2.27456190
63Aplasia/Hypoplasia of the fibula (HP:0006492)2.27391700
64Aplasia cutis congenita (HP:0001057)2.25314079
65Laryngomalacia (HP:0001601)2.25248205
66Aplasia of the phalanges of the hand (HP:0009802)2.24503195
67Aplasia involving bones of the extremities (HP:0009825)2.24503195
68Aplasia involving bones of the upper limbs (HP:0009823)2.24503195
69Chronic otitis media (HP:0000389)2.23983299
70Recurrent abscess formation (HP:0002722)2.21601024
71Hemiparesis (HP:0001269)2.21584574
72Onycholysis (HP:0001806)2.21250680
73Mitral valve prolapse (HP:0001634)2.20593036
74Large for gestational age (HP:0001520)2.19210791
75Spondylolisthesis (HP:0003302)2.19191438
76Mitral regurgitation (HP:0001653)2.18990222
77Hypoplastic iliac wings (HP:0002866)2.17421487
78Partial duplication of thumb phalanx (HP:0009944)2.12667923
79Muscle fiber splitting (HP:0003555)2.08821317
80Sleep apnea (HP:0010535)2.08242942
81Myositis (HP:0100614)2.06865775
82Shallow orbits (HP:0000586)2.04882826
83Abnormality of the ischium (HP:0003174)2.04804015
84Tibial bowing (HP:0002982)2.04032938
85Abnormal respiratory motile cilium physiology (HP:0012261)2.02985294
86Chronic diarrhea (HP:0002028)2.01512110
87Recurrent bacterial skin infections (HP:0005406)2.01237409
88Thick nail (HP:0001805)1.97816843
89Progressive neurologic deterioration (HP:0002344)1.96963137
90Premature rupture of membranes (HP:0001788)1.96893434
91Accelerated skeletal maturation (HP:0005616)1.96785474
92Nasal polyposis (HP:0100582)1.95899201
93Hemiplegia (HP:0002301)1.95629323
94Partial duplication of the phalanx of hand (HP:0009999)1.95519362
95Narrow palate (HP:0000189)1.95420531
96Pulmonary artery stenosis (HP:0004415)1.94560131
97Fragile skin (HP:0001030)1.92407563
98Obstructive sleep apnea (HP:0002870)1.91351261
99Gastrointestinal atresia (HP:0002589)1.89951747
100Abnormal vertebral ossification (HP:0100569)1.88814265
101Abnormal ciliary motility (HP:0012262)1.87960343
102Hypoplastic ilia (HP:0000946)1.87452426
103Abnormality of the radial head (HP:0003995)1.87111836
104Lip pit (HP:0100267)1.85463427
105Abnormality of the fingertips (HP:0001211)1.84374918
106Persistence of primary teeth (HP:0006335)1.84013748
107Trigonocephaly (HP:0000243)1.83951897
108Abnormality of binocular vision (HP:0011514)1.83392290
109Diplopia (HP:0000651)1.83392290
110Exotropia (HP:0000577)1.82882516
111Abnormality of the anterior chamber (HP:0000593)1.82020120
112Fragile nails (HP:0001808)1.80376063
113Abnormality of the humeroradial joint (HP:0100744)1.80181643
114Urinary glycosaminoglycan excretion (HP:0003541)1.80171388
115Mucopolysacchariduria (HP:0008155)1.80171388
116Narrow nasal bridge (HP:0000446)1.79840895
117Depressed nasal tip (HP:0000437)1.79648684
118Soft skin (HP:0000977)1.79634586
119Prominent supraorbital ridges (HP:0000336)1.79603137
120Abnormality of complement system (HP:0005339)1.79117493
121Prostate neoplasm (HP:0100787)1.78923375
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.78884372
123Osteolytic defects of the hand bones (HP:0009699)1.78884372
124Cardiomegaly (HP:0001640)1.78532209
125Alacrima (HP:0000522)1.77172331
126Type II lissencephaly (HP:0007260)1.76770609
127Bicuspid aortic valve (HP:0001647)1.76220345
128Camptodactyly of toe (HP:0001836)1.73974291
129Round ear (HP:0100830)1.73430633
130Broad hallux (HP:0010055)1.72851487
131Tubulointerstitial fibrosis (HP:0005576)1.72188173
132Orchitis (HP:0100796)1.72131106
133Growth hormone excess (HP:0000845)1.71039479
134Axonal loss (HP:0003447)1.71003560
135Hypoplastic ischia (HP:0003175)1.70800378
136Periauricular skin pits (HP:0100277)1.70468977
137Preauricular pit (HP:0004467)1.70468977
138Hypoplastic scapulae (HP:0000882)1.69077554
139Aplasia/Hypoplasia of the scapulae (HP:0006713)1.69077554
140Plantar hyperkeratosis (HP:0007556)1.68915317
141Abnormality of the fibula (HP:0002991)1.68855201
142Scapular winging (HP:0003691)1.68841003
143Prolonged bleeding time (HP:0003010)1.68598347
144Abnormality of the nasal septum (HP:0000419)1.67847993
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67389615
146Abnormality of polysaccharide metabolism (HP:0011012)1.67389615
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67389615
148Bronchiectasis (HP:0002110)1.67014047
149Abnormality of the incisor (HP:0000676)1.66165700
150Segmental peripheral demyelination/remyelination (HP:0003481)1.65698084
151Chin dimple (HP:0010751)1.65636150
152Cellulitis (HP:0100658)1.65487906
153Oligodactyly (hands) (HP:0001180)1.65052388
154Synostosis involving the elbow (HP:0003938)1.64542910
155Humeroradial synostosis (HP:0003041)1.64542910
156Calf muscle hypertrophy (HP:0008981)1.64038676
157Hamartoma (HP:0010566)1.63472774
158Concave nail (HP:0001598)1.63333266
159Hepatosplenomegaly (HP:0001433)1.63194327
160Dislocated radial head (HP:0003083)1.62932534
161Elevated erythrocyte sedimentation rate (HP:0003565)1.62812388
162Hypoventilation (HP:0002791)1.62765469
163Abnormality of incisor morphology (HP:0011063)1.62183432
164Septo-optic dysplasia (HP:0100842)1.62086224
165Deformed sella turcica (HP:0002681)1.61449602
166Nasolacrimal duct obstruction (HP:0000579)1.60658672
167Maternal diabetes (HP:0009800)1.60484965
168Limb-girdle muscle atrophy (HP:0003797)1.60139046
169Aortic regurgitation (HP:0001659)1.60116652
170Vertebral fusion (HP:0002948)1.59547046
171Abnormal number of incisors (HP:0011064)1.59339700
172Down-sloping shoulders (HP:0200021)1.58971471
173Abnormality of the pubic bones (HP:0003172)1.58200824
174Increased density of long bones (HP:0006392)1.58073957
175Split foot (HP:0001839)1.57966468
176Hypoplasia of the iris (HP:0007676)1.56897758
177Esophageal atresia (HP:0002032)1.56649972
178Hypoplasia of dental enamel (HP:0006297)1.56485603
179Joint stiffness (HP:0001387)1.56025203
180Recurrent skin infections (HP:0001581)1.55903152
181Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.55413026
182Aneurysm (HP:0002617)1.54589700
183Impaired platelet aggregation (HP:0003540)1.54476416
184Abnormal platelet function (HP:0011869)1.54476416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.80310560
2MAP2K23.19876627
3TSSK63.13390681
4EPHB12.88100577
5GRK72.87277753
6WEE12.59073446
7MAPKAPK52.49758124
8CSF1R2.30165322
9TRIB32.09961778
10TIE11.98263381
11CDK121.84469596
12TYK21.84104668
13STK101.73391624
14DMPK1.71087879
15NTRK21.61595197
16IRAK31.61205438
17MAP3K141.55054389
18TBK11.50824857
19IKBKB1.49422878
20EPHA31.37988791
21JAK11.36484964
22CLK11.36214937
23TYRO31.34713061
24ITK1.30658502
25NLK1.23384861
26MAP4K11.23304577
27IRAK21.22323669
28PAK41.21210175
29PRPF4B1.19655760
30HIPK21.18277682
31MAP3K31.17280397
32SIK21.16339941
33EPHA21.14937526
34MAPK71.13789552
35MAP3K71.13572241
36MKNK21.13537606
37IRAK41.13154783
38MAPKAPK21.12758466
39PTK61.12388697
40TAOK31.11798941
41CAMK1G1.09418426
42MOS1.09410487
43IRAK11.09262597
44CAMK1D1.07793541
45IKBKE1.06649655
46ERN11.05396364
47MATK1.03424297
48CSK0.99302284
49MST40.99193255
50CHUK0.98744374
51KDR0.96975809
52BTK0.94086334
53MAPKAPK30.91109001
54EEF2K0.90222022
55TRPM70.89694805
56FGFR40.88132221
57PIK3CG0.87905707
58KIT0.85594686
59TTN0.85246760
60BLK0.84447683
61CASK0.82152550
62FGFR20.82027030
63HCK0.80814617
64RIPK10.77898040
65RPS6KA20.77271373
66RPS6KA10.76265563
67GRK10.75633918
68TGFBR10.75037091
69TEC0.74783255
70ADRBK20.74386021
71DYRK1B0.74300235
72DDR20.74228778
73PDGFRA0.74092616
74PDGFRB0.73540681
75UHMK10.73405876
76STK390.71977237
77MAPK120.70710691
78FES0.70404797
79MAP2K30.70200856
80MAPK40.70053894
81RPS6KB20.69527709
82JAK20.69072216
83SIK10.68843607
84FER0.67549464
85EPHB20.67346606
86ZAP700.66696704
87MAP3K20.66370796
88CDK90.65661820
89PRKD20.65584797
90NTRK30.64878215
91LCK0.63966894
92* GSK3A0.63308574
93RPS6KA60.63174213
94TXK0.61972981
95CDC42BPA0.61521004
96PASK0.58440101
97JAK30.58232507
98RPS6KC10.57686040
99RPS6KL10.57686040
100* MTOR0.56721661
101RET0.56687786
102CDK60.55934207
103FGFR30.55575915
104IGF1R0.54260778
105RPS6KA50.54193996
106MAP3K100.53401607
107STK110.52045500
108PKN10.51158808
109ROCK10.50712633
110PRKAA20.49249534
111PTK2B0.49006818
112CAMKK10.48722389
113PNCK0.48302790
114BMPR1B0.48004330
115INSR0.46895523
116SGK20.45938634
117MAP2K10.44854626
118CAMK40.44809286
119RPS6KA40.44672708
120MARK20.44131290
121MAP3K10.42986851
122NEK60.42208324
123* MAPK150.42035275
124TAOK10.41811032
125PTK20.41107385
126* PAK20.41021966
127ICK0.39816533
128* MAPK30.39761398
129* MAPK10.37855046
130NEK90.37058344
131PRKG20.36939149
132SGK2230.36643934
133SGK4940.36643934
134ERBB20.36568402
135YES10.35334802
136DYRK1A0.35273005
137MAP3K60.34259725
138MARK30.33405483
139PIK3CA0.33071363
140AKT30.32925185
141PIM10.30796005

Predicted pathways (KEGG)

RankGene SetZ-score
1* Osteoclast differentiation_Homo sapiens_hsa043802.56994747
2Other glycan degradation_Homo sapiens_hsa005112.41877259
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.40172300
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03793758
5Antigen processing and presentation_Homo sapiens_hsa046121.94747541
6Toxoplasmosis_Homo sapiens_hsa051451.82950803
7Prion diseases_Homo sapiens_hsa050201.74609148
8* B cell receptor signaling pathway_Homo sapiens_hsa046621.73237153
9ECM-receptor interaction_Homo sapiens_hsa045121.66732173
10Staphylococcus aureus infection_Homo sapiens_hsa051501.66499761
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64335314
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.60330546
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57223921
14* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56605773
15Notch signaling pathway_Homo sapiens_hsa043301.55294414
16* Leishmaniasis_Homo sapiens_hsa051401.54795541
17* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52410865
18* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49467597
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.43802532
20Hematopoietic cell lineage_Homo sapiens_hsa046401.35081580
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.33583072
22* TNF signaling pathway_Homo sapiens_hsa046681.32279287
23Malaria_Homo sapiens_hsa051441.29597446
24Lysosome_Homo sapiens_hsa041421.29088647
25* Pertussis_Homo sapiens_hsa051331.28120429
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27874746
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24353816
28* Cocaine addiction_Homo sapiens_hsa050301.22372571
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20083721
30* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13522473
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13029505
32Chronic myeloid leukemia_Homo sapiens_hsa052201.12923748
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.12358298
34Measles_Homo sapiens_hsa051621.11562370
35* Focal adhesion_Homo sapiens_hsa045101.11299288
36Platelet activation_Homo sapiens_hsa046111.11291275
37Hedgehog signaling pathway_Homo sapiens_hsa043401.11133095
38Amoebiasis_Homo sapiens_hsa051461.07978365
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06951502
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06374276
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03217772
42Adherens junction_Homo sapiens_hsa045201.02474264
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01641437
44Pancreatic cancer_Homo sapiens_hsa052121.00146984
45Small cell lung cancer_Homo sapiens_hsa052220.99619163
46Circadian rhythm_Homo sapiens_hsa047100.97133671
47Chemokine signaling pathway_Homo sapiens_hsa040620.96742494
48* Amphetamine addiction_Homo sapiens_hsa050310.96652480
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96398927
50* GnRH signaling pathway_Homo sapiens_hsa049120.96211098
51Protein digestion and absorption_Homo sapiens_hsa049740.95875247
52* MAPK signaling pathway_Homo sapiens_hsa040100.94168533
53* Estrogen signaling pathway_Homo sapiens_hsa049150.92498879
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92254702
55Ether lipid metabolism_Homo sapiens_hsa005650.92224109
56* Choline metabolism in cancer_Homo sapiens_hsa052310.90118125
57* T cell receptor signaling pathway_Homo sapiens_hsa046600.90024616
58* Influenza A_Homo sapiens_hsa051640.90001406
59* cAMP signaling pathway_Homo sapiens_hsa040240.89555383
60Dorso-ventral axis formation_Homo sapiens_hsa043200.89266163
61Legionellosis_Homo sapiens_hsa051340.88620439
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87862181
63Acute myeloid leukemia_Homo sapiens_hsa052210.87272179
64Rap1 signaling pathway_Homo sapiens_hsa040150.86637671
65Endocytosis_Homo sapiens_hsa041440.84889380
66Prolactin signaling pathway_Homo sapiens_hsa049170.84795124
67* Pathways in cancer_Homo sapiens_hsa052000.84350885
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.84131889
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.82887831
70Sphingolipid metabolism_Homo sapiens_hsa006000.82688235
71TGF-beta signaling pathway_Homo sapiens_hsa043500.81269875
72Tuberculosis_Homo sapiens_hsa051520.81217228
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80311349
74* Apoptosis_Homo sapiens_hsa042100.80242063
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79953080
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79937146
77Melanogenesis_Homo sapiens_hsa049160.79651051
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79230552
79Axon guidance_Homo sapiens_hsa043600.79190078
80Proteoglycans in cancer_Homo sapiens_hsa052050.78681869
81Prostate cancer_Homo sapiens_hsa052150.78656761
82ABC transporters_Homo sapiens_hsa020100.77383719
83* ErbB signaling pathway_Homo sapiens_hsa040120.76683232
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76120122
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76055158
86* Hepatitis B_Homo sapiens_hsa051610.75758057
87Cholinergic synapse_Homo sapiens_hsa047250.74736948
88African trypanosomiasis_Homo sapiens_hsa051430.74108635
89Gastric acid secretion_Homo sapiens_hsa049710.73811314
90Circadian entrainment_Homo sapiens_hsa047130.73801093
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73586997
92Bladder cancer_Homo sapiens_hsa052190.72020458
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70337706
94Ras signaling pathway_Homo sapiens_hsa040140.69334337
95* HTLV-I infection_Homo sapiens_hsa051660.69216413
96Hepatitis C_Homo sapiens_hsa051600.68273315
97Gap junction_Homo sapiens_hsa045400.68165078
98* Colorectal cancer_Homo sapiens_hsa052100.67836537
99* Renal cell carcinoma_Homo sapiens_hsa052110.66654555
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.65868996
101* Salmonella infection_Homo sapiens_hsa051320.65052892
102Nitrogen metabolism_Homo sapiens_hsa009100.64892198
103Bile secretion_Homo sapiens_hsa049760.64192725
104* Rheumatoid arthritis_Homo sapiens_hsa053230.63711732
105* Oxytocin signaling pathway_Homo sapiens_hsa049210.63472581
106Glutamatergic synapse_Homo sapiens_hsa047240.63225611
107Salivary secretion_Homo sapiens_hsa049700.63170679
108VEGF signaling pathway_Homo sapiens_hsa043700.62862782
109Insulin secretion_Homo sapiens_hsa049110.62105270
110FoxO signaling pathway_Homo sapiens_hsa040680.61841842
111Renin secretion_Homo sapiens_hsa049240.61819072
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.61092313
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.60449134
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60267163
115Basal cell carcinoma_Homo sapiens_hsa052170.60186041
116Type II diabetes mellitus_Homo sapiens_hsa049300.59824712
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59134260
118MicroRNAs in cancer_Homo sapiens_hsa052060.59009786
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58935794
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58680049
121Dilated cardiomyopathy_Homo sapiens_hsa054140.57808922
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57807437
123Primary immunodeficiency_Homo sapiens_hsa053400.56729777
124* Neurotrophin signaling pathway_Homo sapiens_hsa047220.56140431
125Hippo signaling pathway_Homo sapiens_hsa043900.55540132
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55519972
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55407818
128Endometrial cancer_Homo sapiens_hsa052130.55247563
129Pancreatic secretion_Homo sapiens_hsa049720.53644609
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52910395
131Insulin resistance_Homo sapiens_hsa049310.52718034
132* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52371008
133Shigellosis_Homo sapiens_hsa051310.49944847
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48433668

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