JSRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)9.79057758
2skeletal muscle fiber development (GO:0048741)9.58111804
3actin filament-based movement (GO:0030048)8.21431522
4myotube cell development (GO:0014904)8.16055839
5plasma membrane repair (GO:0001778)7.95719756
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.15302415
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.84848649
8striated muscle atrophy (GO:0014891)6.69634462
9sarcomere organization (GO:0045214)6.66118897
10skeletal muscle tissue regeneration (GO:0043403)6.60836585
11* striated muscle contraction (GO:0006941)6.53378041
12response to inactivity (GO:0014854)6.34843627
13glycogen catabolic process (GO:0005980)6.13607012
14response to muscle activity (GO:0014850)5.93933203
15muscle atrophy (GO:0014889)5.89551081
16purine nucleotide salvage (GO:0032261)5.89186800
17creatine metabolic process (GO:0006600)5.87099781
18myofibril assembly (GO:0030239)5.81757440
19glucan catabolic process (GO:0009251)5.73895436
20* muscle contraction (GO:0006936)5.73317045
21muscle fiber development (GO:0048747)5.55177243
22striated muscle adaptation (GO:0014888)5.51811200
23pyrimidine ribonucleoside catabolic process (GO:0046133)5.51672070
24regulation of cell communication by electrical coupling (GO:0010649)5.49250613
25neutrophil activation involved in immune response (GO:0002283)5.38925910
26cellular polysaccharide catabolic process (GO:0044247)5.35863375
27regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.34217886
28carnitine shuttle (GO:0006853)5.30852820
29cytidine metabolic process (GO:0046087)5.14857973
30cytidine catabolic process (GO:0006216)5.14857973
31cytidine deamination (GO:0009972)5.14857973
32IMP metabolic process (GO:0046040)5.11675278
33* muscle system process (GO:0003012)5.09969275
34polysaccharide catabolic process (GO:0000272)5.09127431
35glycogen biosynthetic process (GO:0005978)4.97906195
36glucan biosynthetic process (GO:0009250)4.97906195
37actomyosin structure organization (GO:0031032)4.86103947
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.82149734
39positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.67875528
40muscle cell fate commitment (GO:0042693)4.63441592
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.61990166
42positive regulation of myotube differentiation (GO:0010831)4.60082080
43regulation of skeletal muscle cell differentiation (GO:2001014)4.57307440
44* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.51161804
45muscle adaptation (GO:0043500)4.45922896
46myotube differentiation (GO:0014902)4.41750464
47muscle organ development (GO:0007517)4.41286954
48neuromuscular synaptic transmission (GO:0007274)4.41064097
49fatty acid transmembrane transport (GO:1902001)4.39826648
50muscle cell cellular homeostasis (GO:0046716)4.38159489
51muscle structure development (GO:0061061)4.34149008
52skeletal muscle tissue development (GO:0007519)4.31092701
53myoblast fusion (GO:0007520)4.22398897
54regulation of acyl-CoA biosynthetic process (GO:0050812)4.22112776
55glycogen metabolic process (GO:0005977)4.21361751
56glucan metabolic process (GO:0044042)4.12739401
57cellular glucan metabolic process (GO:0006073)4.12739401
58striated muscle cell development (GO:0055002)4.07030638
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.02792906
60IMP biosynthetic process (GO:0006188)4.01689975
61neuronal action potential propagation (GO:0019227)3.96528185
62positive regulation of myoblast differentiation (GO:0045663)3.94455810
63response to activity (GO:0014823)3.91828276
64negative regulation of skeletal muscle tissue development (GO:0048642)3.89861147
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.88485900
66regulation of relaxation of muscle (GO:1901077)3.87954865
67carnitine transmembrane transport (GO:1902603)3.85474520
68cardiac muscle contraction (GO:0060048)3.81752753
69regulation of cofactor metabolic process (GO:0051193)3.81733120
70regulation of coenzyme metabolic process (GO:0051196)3.81733120
71syncytium formation by plasma membrane fusion (GO:0000768)3.75669445
72syncytium formation (GO:0006949)3.74095047
73negative regulation of muscle hypertrophy (GO:0014741)3.73559172
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.68898183
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60527563
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59289667
77negative regulation of cell killing (GO:0031342)3.59289667
78muscle cell development (GO:0055001)3.50865146
79neutrophil activation (GO:0042119)3.49622186
80carnitine transport (GO:0015879)3.49376356
81amino-acid betaine transport (GO:0015838)3.49376356
82regulation of myoblast differentiation (GO:0045661)3.49141380
83negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.45247547
84granulocyte activation (GO:0036230)3.44023746
85neuromuscular junction development (GO:0007528)3.43736990
86cellular carbohydrate catabolic process (GO:0044275)3.40624988
87cellular response to dexamethasone stimulus (GO:0071549)3.39728428
88negative regulation of interleukin-12 production (GO:0032695)3.37762775
89tricarboxylic acid cycle (GO:0006099)3.35386429
90regulation of striated muscle contraction (GO:0006942)3.33298181
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27580208
92protein neddylation (GO:0045116)3.25755842
93positive regulation of mast cell activation (GO:0033005)3.25555667
94skeletal muscle cell differentiation (GO:0035914)3.22842555
95cardiac myofibril assembly (GO:0055003)3.22150457
96negative regulation of cAMP-mediated signaling (GO:0043951)3.20532449
97response to dexamethasone (GO:0071548)3.14266506
98immunoglobulin mediated immune response (GO:0016064)3.11083881
99response to peptidoglycan (GO:0032494)3.08709756
100regulation of actin filament-based movement (GO:1903115)3.07992348
101regulation of sulfur metabolic process (GO:0042762)3.07896509
102regulation of chronic inflammatory response (GO:0002676)3.06744797
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05564907
104regulation of myotube differentiation (GO:0010830)3.03521169
105cellular polysaccharide biosynthetic process (GO:0033692)3.00307072
106heart process (GO:0003015)2.99595433
107regulation of mast cell degranulation (GO:0043304)2.96058675
108regulation of platelet activation (GO:0010543)2.86869236
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79600573
110negative regulation of thymocyte apoptotic process (GO:0070244)2.79359118
111germinal center formation (GO:0002467)2.79205551
112regulation of platelet aggregation (GO:0090330)2.79145473
113regulation of mast cell activation (GO:0033003)2.78492644
114positive regulation of mast cell degranulation (GO:0043306)2.70671244
115positive regulation of mast cell activation involved in immune response (GO:0033008)2.70671244
116regulation of mast cell activation involved in immune response (GO:0033006)2.67357567
117lipoxygenase pathway (GO:0019372)2.67311705
118B cell mediated immunity (GO:0019724)2.67184877
119regulation of T-helper 1 cell differentiation (GO:0045625)2.67129064
120positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65290909
121positive regulation of B cell mediated immunity (GO:0002714)2.63782676
122positive regulation of immunoglobulin mediated immune response (GO:0002891)2.63782676
123regulation of T cell mediated cytotoxicity (GO:0001914)2.63708610
124leukocyte degranulation (GO:0043299)2.62462410
125myeloid cell activation involved in immune response (GO:0002275)2.61110421
126positive regulation of cellular amide metabolic process (GO:0034250)2.60531145
127mitochondrial calcium ion transport (GO:0006851)2.57993038
128NIK/NF-kappaB signaling (GO:0038061)2.56031366
129antigen processing and presentation via MHC class Ib (GO:0002475)2.56001158
130interferon-gamma-mediated signaling pathway (GO:0060333)2.55890439
131purinergic nucleotide receptor signaling pathway (GO:0035590)2.53411407
132mitochondrial calcium ion homeostasis (GO:0051560)2.53255647
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52268316
134leukocyte migration involved in inflammatory response (GO:0002523)2.51351144
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.49317187
136G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.48956780
137positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48948816
138regulation of inflammatory response to antigenic stimulus (GO:0002861)2.48170984
139negative regulation of cytokine production involved in immune response (GO:0002719)2.44849806
140leukocyte aggregation (GO:0070486)2.42995026
141positive regulation of macrophage differentiation (GO:0045651)2.42480034
142pyrimidine nucleoside catabolic process (GO:0046135)2.41879850
143adenosine receptor signaling pathway (GO:0001973)2.41002564
144phagosome maturation (GO:0090382)2.39318630
145purine-containing compound salvage (GO:0043101)2.38037813
146N-acetylneuraminate metabolic process (GO:0006054)2.37708407
147negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37696625
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37353444
149positive regulation of gamma-delta T cell activation (GO:0046645)2.37079100
150adenosine metabolic process (GO:0046085)2.36601787
151antigen processing and presentation of endogenous antigen (GO:0019883)2.35369251
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35348655
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34346900
154cellular response to arsenic-containing substance (GO:0071243)2.33655369
155purinergic receptor signaling pathway (GO:0035587)2.32828657
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.32607416
157glycosphingolipid catabolic process (GO:0046479)2.32155116
158regulation of vitamin D biosynthetic process (GO:0060556)2.29946743
159tolerance induction (GO:0002507)2.29809761
160autophagic vacuole fusion (GO:0000046)2.28921618
161regulation of leukocyte degranulation (GO:0043300)2.28839143
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.28729236
163polyamine biosynthetic process (GO:0006596)2.28481585
164regulation of interleukin-12 production (GO:0032655)2.26806246
165cellular response to type I interferon (GO:0071357)2.26659011
166type I interferon signaling pathway (GO:0060337)2.26659011
167regulation of myeloid leukocyte mediated immunity (GO:0002886)2.26216793
168lymphocyte chemotaxis (GO:0048247)2.25583567
169positive regulation of monocyte chemotaxis (GO:0090026)2.25178760
170positive regulation of isotype switching (GO:0045830)2.23440447
171positive regulation of interleukin-17 production (GO:0032740)2.23240240
172negative regulation of T cell apoptotic process (GO:0070233)2.22795810
173positive regulation of DNA recombination (GO:0045911)2.21990496
174cellular response to thyroid hormone stimulus (GO:0097067)2.21832450
175negative regulation of platelet activation (GO:0010544)2.21505949
176response to type I interferon (GO:0034340)2.21483752
177positive regulation of interleukin-10 production (GO:0032733)2.21041256
178muscle filament sliding (GO:0030049)13.4751766
179actin-myosin filament sliding (GO:0033275)13.4751766
180regulation of skeletal muscle contraction (GO:0014819)12.0996846
181* skeletal muscle contraction (GO:0003009)11.0997105
182actin-mediated cell contraction (GO:0070252)11.0296429
183sarcoplasmic reticulum calcium ion transport (GO:0070296)10.6224943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.45733050
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.08875071
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86044887
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85490650
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.74950262
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.60309395
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.18323556
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.12387272
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83259476
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.76335433
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72117625
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68061733
13BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.52846427
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.50114465
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.50114465
16LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.49094928
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45452973
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.43679239
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41440491
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39488715
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35855857
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34793581
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32890763
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30470016
25ZNF263_19887448_ChIP-Seq_K562_Human2.24565215
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22096026
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17005241
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.16182372
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.16094363
30MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.14496319
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09618839
32CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09381112
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99156067
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98768905
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98449341
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.97647577
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97054073
38SPI1_23127762_ChIP-Seq_K562_Human1.94913776
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.94671971
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90340348
41* SPI1_23547873_ChIP-Seq_NB4_Human1.90165435
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84974509
43* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.84215489
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83842618
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83677008
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80757786
47CTCF_27219007_Chip-Seq_Bcells_Human1.78356868
48SCL_19346495_ChIP-Seq_HPC-7_Human1.78046821
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77155065
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76271734
51ZNF274_21170338_ChIP-Seq_K562_Hela1.70778996
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.69490894
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66839004
54MAF_26560356_Chip-Seq_TH1_Human1.65568177
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63390253
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61484419
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61088563
58RUNX_20019798_ChIP-Seq_JUKART_Human1.60813883
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60738391
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.59099408
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58712013
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58546384
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57642269
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56508653
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55596294
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52824438
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52666803
68MYB_26560356_Chip-Seq_TH2_Human1.52530419
69VDR_24763502_ChIP-Seq_THP-1_Human1.51285048
70SA1_27219007_Chip-Seq_Bcells_Human1.51100521
71KDM2B_26808549_Chip-Seq_DND41_Human1.46573062
72CTCF_21964334_Chip-Seq_Bcells_Human1.46422075
73UTX_26944678_Chip-Seq_JUKART_Human1.45497715
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44812000
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42322336
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42262876
77AR_21572438_ChIP-Seq_LNCaP_Human1.42201243
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41645402
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41097852
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40960206
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38470178
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.37981952
83CLOCK_20551151_ChIP-Seq_293T_Human1.37793502
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37511334
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.36534265
86VDR_21846776_ChIP-Seq_THP-1_Human1.36131677
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34139330
88* BCOR_27268052_Chip-Seq_Bcells_Human1.33173878
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32251208
90* FOXH1_21741376_ChIP-Seq_ESCs_Human1.31510082
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30267077
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30229823
93GATA1_19941826_ChIP-Seq_K562_Human1.29514348
94SMC3_22415368_ChIP-Seq_MEFs_Mouse1.29464483
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29404765
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29262050
97TFEB_21752829_ChIP-Seq_HELA_Human1.28373464
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.27696315
99TCF7_22412390_ChIP-Seq_EML_Mouse1.27249606
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26391626
101LXR_22292898_ChIP-Seq_THP-1_Human1.25966647
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25841804
103OCT4_20526341_ChIP-Seq_ESCs_Human1.25182424
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.24174048
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23796081
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23211303
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21345968
108EZH2_22144423_ChIP-Seq_EOC_Human1.20932199
109RACK7_27058665_Chip-Seq_MCF-7_Human1.20480155
110STAT1_20625510_ChIP-Seq_HELA_Human1.20390454
111GATA3_26560356_Chip-Seq_TH2_Human1.20001669
112* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19508146
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19479271
114GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19120229
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18765851
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18271245
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18109423
118* MAF_26560356_Chip-Seq_TH2_Human1.16827308
119TP53_20018659_ChIP-ChIP_R1E_Mouse1.15004220
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.14887615
121CREB1_26743006_Chip-Seq_LNCaP_Human1.14631032
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14620295
123MYC_22102868_ChIP-Seq_BL_Human1.12851322
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12488332
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11829792
126GATA3_27048872_Chip-Seq_THYMUS_Human1.10662840
127MYB_26560356_Chip-Seq_TH1_Human1.10476432
128DROSHA_22980978_ChIP-Seq_HELA_Human1.10268290
129PU_27001747_Chip-Seq_BMDM_Mouse1.09454967
130NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09191019
131ATF3_27146783_Chip-Seq_COLON_Human1.07889506
132P300_27268052_Chip-Seq_Bcells_Human1.07856241
133EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07182913
134CBP_20019798_ChIP-Seq_JUKART_Human1.05683765
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05683765
136P68_20966046_ChIP-Seq_HELA_Human1.05545587
137BCL6_27268052_Chip-Seq_Bcells_Human1.04133599
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03972591
139RARB_27405468_Chip-Seq_BRAIN_Mouse1.03481810
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03309428
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02437982
142NANOG_20526341_ChIP-Seq_ESCs_Human1.02224627
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00548036
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00362602
145* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00227236
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.99514022
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.99349452
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.99302788
149GATA2_19941826_ChIP-Seq_K562_Human0.99036904
150P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98087289
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97327474
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.97105143
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97022833
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96880523
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96317418
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95833407
157SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95483978
158* CTCF_26484167_Chip-Seq_Bcells_Mouse0.94695907
159E2F1_20622854_ChIP-Seq_HELA_Human0.94657676
160TP63_17297297_ChIP-ChIP_HaCaT_Human0.94559665
161SPI1_20517297_ChIP-Seq_HL60_Human0.94348831
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93898051
163ELK3_25401928_ChIP-Seq_HUVEC_Human0.93896080
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92946363
165* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92747275
166HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92017507
167CEBPB_22108803_ChIP-Seq_LS180_Human0.91328077
168ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90566345
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90479313
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90065253
171PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88945447
172TP63_22573176_ChIP-Seq_HFKS_Human0.87692258
173LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85706237
174PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85178420
175CJUN_26792858_Chip-Seq_BT549_Human0.84745724
176KDM2B_26808549_Chip-Seq_K562_Human0.83926483
177* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83828596
178* RAC3_21632823_ChIP-Seq_H3396_Human0.83578491
179CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81680852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.13845477
2MP0000749_muscle_degeneration6.74122425
3MP0000751_myopathy6.02759078
4MP0003646_muscle_fatigue5.83949286
5* MP0002106_abnormal_muscle_physiology4.25800107
6* MP0000747_muscle_weakness4.14778082
7MP0000759_abnormal_skeletal_muscle4.05250416
8MP0004036_abnormal_muscle_relaxation3.82997483
9MP0000750_abnormal_muscle_regeneration3.67573315
10MP0005464_abnormal_platelet_physiology3.66467714
11MP0002269_muscular_atrophy3.65917751
12* MP0005369_muscle_phenotype3.55420606
13MP0004087_abnormal_muscle_fiber3.53909351
14MP0002837_dystrophic_cardiac_calcinosis3.39692203
15MP0003303_peritoneal_inflammation3.35664704
16MP0003724_increased_susceptibility_to3.34686642
17MP0004130_abnormal_muscle_cell3.11052542
18MP0001835_abnormal_antigen_presentation3.08630819
19MP0005620_abnormal_muscle_contractility3.05020516
20MP0000733_abnormal_muscle_development3.04125108
21MP0003436_decreased_susceptibility_to2.89198417
22MP0004233_abnormal_muscle_weight2.82054011
23MP0002148_abnormal_hypersensitivity_rea2.81176896
24MP0005058_abnormal_lysosome_morphology2.77642472
25MP0005451_abnormal_body_composition2.73064762
26MP0005671_abnormal_response_to2.63901200
27MP0000685_abnormal_immune_system2.40595929
28MP0009785_altered_susceptibility_to2.40248775
29MP0005000_abnormal_immune_tolerance2.37414647
30MP0002108_abnormal_muscle_morphology2.20008661
31MP0005387_immune_system_phenotype2.11328393
32MP0001790_abnormal_immune_system2.11328393
33MP0002332_abnormal_exercise_endurance2.09539706
34MP0002419_abnormal_innate_immunity1.98049918
35MP0002723_abnormal_immune_serum1.95051320
36MP0001800_abnormal_humoral_immune1.94854992
37MP0005025_abnormal_response_to1.91776400
38MP0004270_analgesia1.91487767
39MP0002452_abnormal_antigen_presenting1.88275492
40MP0009840_abnormal_foam_cell1.88263194
41MP0005330_cardiomyopathy1.88249562
42MP0001533_abnormal_skeleton_physiology1.86849225
43MP0009764_decreased_sensitivity_to1.86156547
44MP0008004_abnormal_stomach_pH1.83841246
45MP0006036_abnormal_mitochondrial_physio1.76072042
46MP0009333_abnormal_splenocyte_physiolog1.69139155
47MP0003075_altered_response_to1.68097221
48MP0004084_abnormal_cardiac_muscle1.67906163
49MP0006082_CNS_inflammation1.67122830
50MP0001819_abnormal_immune_cell1.63368045
51MP0002420_abnormal_adaptive_immunity1.63120480
52MP0010155_abnormal_intestine_physiology1.62740925
53MP0001845_abnormal_inflammatory_respons1.57577459
54MP0004185_abnormal_adipocyte_glucose1.51935136
55MP0002971_abnormal_brown_adipose1.49594028
56MP0004947_skin_inflammation1.46989486
57MP0003191_abnormal_cellular_cholesterol1.42275530
58MP0003300_gastrointestinal_ulcer1.38549799
59MP0004215_abnormal_myocardial_fiber1.36883959
60MP0005167_abnormal_blood-brain_barrier1.35254882
61MP0008469_abnormal_protein_level1.33357549
62MP0005666_abnormal_adipose_tissue1.26931133
63MP0000465_gastrointestinal_hemorrhage1.26822775
64MP0003172_abnormal_lysosome_physiology1.25224255
65MP0002972_abnormal_cardiac_muscle1.24931838
66MP0004484_altered_response_of1.21583617
67MP0010630_abnormal_cardiac_muscle1.20868104
68MP0002398_abnormal_bone_marrow1.19856976
69MP0000716_abnormal_immune_system1.19211621
70MP0000013_abnormal_adipose_tissue1.19104508
71MP0002139_abnormal_hepatobiliary_system1.13309028
72MP0003763_abnormal_thymus_physiology1.11736841
73MP0000858_altered_metastatic_potential1.10147180
74MP0002998_abnormal_bone_remodeling1.09643097
75MP0000689_abnormal_spleen_morphology1.08750581
76MP0002405_respiratory_system_inflammati1.08228970
77MP0003950_abnormal_plasma_membrane1.08108322
78MP0009278_abnormal_bone_marrow1.06707888
79MP0002234_abnormal_pharynx_morphology1.05868139
80MP0003221_abnormal_cardiomyocyte_apopto1.03324872
81MP0005165_increased_susceptibility_to1.03160764
82MP0002429_abnormal_blood_cell1.03050747
83MP0005375_adipose_tissue_phenotype1.02615260
84MP0005266_abnormal_metabolism1.01398110
85MP0002138_abnormal_hepatobiliary_system0.98919721
86MP0001853_heart_inflammation0.97059231
87MP0001663_abnormal_digestive_system0.96552735
88MP0008260_abnormal_autophagy0.94098970
89MP0005397_hematopoietic_system_phenotyp0.91901547
90MP0001545_abnormal_hematopoietic_system0.91901547
91MP0002722_abnormal_immune_system0.91789900
92MP0004134_abnormal_chest_morphology0.91766668
93MP0006035_abnormal_mitochondrial_morpho0.90596495
94MP0003638_abnormal_response/metabolism_0.89976604
95MP0003806_abnormal_nucleotide_metabolis0.89883776
96MP0009763_increased_sensitivity_to0.89726049
97MP0005310_abnormal_salivary_gland0.84966416
98MP0009250_abnormal_appendicular_skeleto0.81956778
99MP0005385_cardiovascular_system_phenoty0.81871263
100MP0001544_abnormal_cardiovascular_syste0.81871263
101MP0001299_abnormal_eye_distance/0.80557298
102MP0003186_abnormal_redox_activity0.80513093
103MP0008961_abnormal_basal_metabolism0.77366645
104MP0002693_abnormal_pancreas_physiology0.77192631
105MP0000249_abnormal_blood_vessel0.77010833
106MP0000372_irregular_coat_pigmentation0.76070197
107MP0003448_altered_tumor_morphology0.75661402
108MP0004147_increased_porphyrin_level0.74145299
109MP0003705_abnormal_hypodermis_morpholog0.73982699
110MP0001542_abnormal_bone_strength0.72856676
111MP0001873_stomach_inflammation0.72485222
112MP0005390_skeleton_phenotype0.72379732
113MP0003137_abnormal_impulse_conducting0.71809981
114MP0003195_calcinosis0.70876417
115MP0003866_abnormal_defecation0.70464408
116MP0000762_abnormal_tongue_morphology0.67092255
117MP0003656_abnormal_erythrocyte_physiolo0.66134835
118MP0000003_abnormal_adipose_tissue0.65994766
119MP0005275_abnormal_skin_tensile0.60334451
120MP0005670_abnormal_white_adipose0.57777876
121MP0005334_abnormal_fat_pad0.54846755
122MP0000266_abnormal_heart_morphology0.53081405
123MP0002078_abnormal_glucose_homeostasis0.51309042
124MP0008569_lethality_at_weaning0.50088693
125MP0002114_abnormal_axial_skeleton0.49576375
126MP0002127_abnormal_cardiovascular_syste0.48888989
127MP0002089_abnormal_postnatal_growth/wei0.47329161
128MP0004043_abnormal_pH_regulation0.47051256
129MP0005452_abnormal_adipose_tissue0.46240019
130MP0002896_abnormal_bone_mineralization0.40484509
131MP0003959_abnormal_lean_body0.38850109
132MP0000343_altered_response_to0.38803927
133MP0006138_congestive_heart_failure0.38075928
134MP0008775_abnormal_heart_ventricle0.36356729
135MP0003948_abnormal_gas_homeostasis0.35177201
136MP0009672_abnormal_birth_weight0.34622414
137MP0003045_fibrosis0.33015849
138MP0002249_abnormal_larynx_morphology0.32681478
139MP0005584_abnormal_enzyme/coenzyme_acti0.32217574
140MP0004510_myositis0.31618668
141MP0004142_abnormal_muscle_tone0.31074448
142MP0005319_abnormal_enzyme/_coenzyme0.30855154
143MP0001849_ear_inflammation0.30507090
144MP0009115_abnormal_fat_cell0.29510901
145MP0001943_abnormal_respiration0.29113635
146MP0004085_abnormal_heartbeat0.27902407
147MP0009780_abnormal_chondrocyte_physiolo0.27595488
148MP0005503_abnormal_tendon_morphology0.27394399
149MP0010030_abnormal_orbit_morphology0.27232494
150MP0001243_abnormal_dermal_layer0.26787156
151MP0005083_abnormal_biliary_tract0.26194981
152MP0002932_abnormal_joint_morphology0.24157814
153MP0003828_pulmonary_edema0.23609600
154MP0002128_abnormal_blood_circulation0.23471618
155MP0003755_abnormal_palate_morphology0.23409206
156MP0004197_abnormal_fetal_growth/weight/0.22973023
157MP0008770_decreased_survivor_rate0.22777477
158MP0003567_abnormal_fetal_cardiomyocyte0.22367545
159MP0002734_abnormal_mechanical_nocicepti0.21745354
160MP0003385_abnormal_body_wall0.20973999
161MP0005376_homeostasis/metabolism_phenot0.19135365
162MP0000678_abnormal_parathyroid_gland0.18613691
163MP0000230_abnormal_systemic_arterial0.18108604
164MP0002109_abnormal_limb_morphology0.17505946
165MP0003879_abnormal_hair_cell0.16610886
166MP0005535_abnormal_body_temperature0.16610795
167MP0005166_decreased_susceptibility_to0.16326045

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.88485308
2Nemaline bodies (HP:0003798)9.33587322
3Exercise-induced myalgia (HP:0003738)7.91765368
4Type 1 muscle fiber predominance (HP:0003803)7.67254184
5Distal arthrogryposis (HP:0005684)7.55850681
6Exercise-induced muscle cramps (HP:0003710)7.09070922
7Myopathic facies (HP:0002058)6.72056143
8Round ear (HP:0100830)6.45071139
9Muscle hypertrophy of the lower extremities (HP:0008968)6.42413485
10Ulnar deviation of the wrist (HP:0003049)6.38909956
11Calf muscle hypertrophy (HP:0008981)5.76862476
12Calcaneovalgus deformity (HP:0001848)5.57223523
13Difficulty running (HP:0009046)5.30047092
14Deformed tarsal bones (HP:0008119)5.10389963
15Muscle fiber splitting (HP:0003555)5.06211206
16Absent phalangeal crease (HP:0006109)5.05743627
17Hyporeflexia of lower limbs (HP:0002600)4.64213391
18Myoglobinuria (HP:0002913)4.57420525
19EMG: myopathic abnormalities (HP:0003458)4.50980544
20Malignant hyperthermia (HP:0002047)4.40768359
21Muscle stiffness (HP:0003552)4.25893309
22Petechiae (HP:0000967)4.23743910
23Abnormal finger flexion creases (HP:0006143)4.23628588
24Increased connective tissue (HP:0009025)4.17858282
25Abnormality of the calf musculature (HP:0001430)4.10540083
26Abnormality of skeletal muscle fiber size (HP:0012084)4.06147150
27Myotonia (HP:0002486)3.86219894
28Rhabdomyolysis (HP:0003201)3.85098265
29Prolonged bleeding time (HP:0003010)3.83809964
30Difficulty climbing stairs (HP:0003551)3.64318394
31Neck muscle weakness (HP:0000467)3.53583434
32Increased variability in muscle fiber diameter (HP:0003557)3.53558931
33Purpura (HP:0000979)3.53089197
34Stomatitis (HP:0010280)3.46433786
35Abnormality of the neuromuscular junction (HP:0003398)3.39982096
36Fatigable weakness (HP:0003473)3.39982096
37Abnormality of the calcaneus (HP:0008364)3.38654974
38Fetal akinesia sequence (HP:0001989)3.37163891
39Abnormality of glycolipid metabolism (HP:0010969)3.35365381
40Abnormality of liposaccharide metabolism (HP:0010968)3.35365381
41Abnormality of glycosphingolipid metabolism (HP:0004343)3.35365381
42Subaortic stenosis (HP:0001682)3.20325996
43Abnormality of the left ventricular outflow tract (HP:0011103)3.20325996
44Frequent falls (HP:0002359)3.19548085
45Rimmed vacuoles (HP:0003805)3.19021556
46Shoulder girdle muscle weakness (HP:0003547)3.17390185
47Pelvic girdle muscle weakness (HP:0003749)3.15112658
48Abnormality of macrophages (HP:0004311)3.11672061
49Abnormality of the musculature of the pelvis (HP:0001469)3.05079011
50Abnormality of the hip-girdle musculature (HP:0001445)3.05079011
51Areflexia of lower limbs (HP:0002522)2.96535796
52Menorrhagia (HP:0000132)2.86301862
53Vacuolated lymphocytes (HP:0001922)2.82714417
54Epistaxis (HP:0000421)2.80072682
55Weak cry (HP:0001612)2.79001585
56Slender build (HP:0001533)2.78451513
57Bulbar palsy (HP:0001283)2.76715530
58Mildly elevated creatine phosphokinase (HP:0008180)2.64485184
59Hyperkalemia (HP:0002153)2.64275658
60Abnormal platelet volume (HP:0011876)2.60370971
61Increased serum ferritin (HP:0003281)2.58256577
62Gowers sign (HP:0003391)2.57537381
63Eczematoid dermatitis (HP:0000976)2.54569938
64Asymmetric septal hypertrophy (HP:0001670)2.54558386
65Increased mean platelet volume (HP:0011877)2.53422506
66Generalized muscle weakness (HP:0003324)2.52294270
67Recurrent abscess formation (HP:0002722)2.51076076
68EMG: neuropathic changes (HP:0003445)2.49397567
69Type 2 muscle fiber atrophy (HP:0003554)2.47183910
70Recurrent bacterial skin infections (HP:0005406)2.46957668
71Dysostosis multiplex (HP:0000943)2.45057400
72Distal lower limb muscle weakness (HP:0009053)2.43454151
73Abnormality of lateral ventricle (HP:0030047)2.42821817
74Abnormality of iron homeostasis (HP:0011031)2.38770592
75Increased cerebral lipofuscin (HP:0011813)2.37497476
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.35158890
77Myositis (HP:0100614)2.33539282
78Nonprogressive disorder (HP:0003680)2.33516620
79Sudden death (HP:0001699)2.32269076
80Elevated erythrocyte sedimentation rate (HP:0003565)2.26509512
81Muscular dystrophy (HP:0003560)2.23418603
82Optic neuritis (HP:0100653)2.23293520
83Retrobulbar optic neuritis (HP:0100654)2.23293520
84Paralysis (HP:0003470)2.22254054
85Muscle fiber atrophy (HP:0100295)2.22238434
86Spinal rigidity (HP:0003306)2.21287457
87Distal lower limb amyotrophy (HP:0008944)2.20027785
88Orchitis (HP:0100796)2.19102874
89Facial diplegia (HP:0001349)2.18632774
90Increased intramyocellular lipid droplets (HP:0012240)2.18397975
91Limb-girdle muscle weakness (HP:0003325)2.17078438
92Scapular winging (HP:0003691)2.15833821
93Metatarsus adductus (HP:0001840)2.15652397
94Chronic obstructive pulmonary disease (HP:0006510)2.14209594
95Obstructive lung disease (HP:0006536)2.14209594
96Proximal amyotrophy (HP:0007126)2.13548907
97Hypoplastic ischia (HP:0003175)2.13090792
98Popliteal pterygium (HP:0009756)2.13081117
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.12918524
100Ulnar deviation of finger (HP:0009465)2.12849563
101Hepatosplenomegaly (HP:0001433)2.12027749
102Limb-girdle muscle atrophy (HP:0003797)2.10722805
1033-Methylglutaconic aciduria (HP:0003535)2.10422542
104Abnormality of transition element cation homeostasis (HP:0011030)2.10119505
105Abnormality of the shoulder girdle musculature (HP:0001435)2.10074898
106Hyperlipoproteinemia (HP:0010980)2.09418274
107Nausea (HP:0002018)2.07702569
108Increased muscle lipid content (HP:0009058)2.06414147
109Muscle fibrillation (HP:0010546)2.05665101
110Generalized aminoaciduria (HP:0002909)2.04185386
111Gingival bleeding (HP:0000225)2.00246197
112Hip contracture (HP:0003273)2.00241782
113Muscle fiber inclusion bodies (HP:0100299)10.2091950
114Mediastinal lymphadenopathy (HP:0100721)1.97232715
115Tongue fasciculations (HP:0001308)1.96517885
116Increased IgM level (HP:0003496)1.96159192
117Encephalitis (HP:0002383)1.96044093
118Long clavicles (HP:0000890)1.92739993
119Progressive muscle weakness (HP:0003323)1.89794244
120Abnormal platelet function (HP:0011869)1.88849039
121Impaired platelet aggregation (HP:0003540)1.88849039
122Abnormal pupillary function (HP:0007686)1.88610107
123Waddling gait (HP:0002515)1.88499344
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87045232
125Spontaneous hematomas (HP:0007420)1.86145584
126Respiratory insufficiency due to muscle weakness (HP:0002747)1.84205285
127Abnormality of the ischium (HP:0003174)1.84024945
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82792653
129Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82792653
130Easy fatigability (HP:0003388)1.79352447
131Polyneuropathy (HP:0001271)1.78509539
132Amniotic constriction ring (HP:0009775)1.78081584
133Abnormality of placental membranes (HP:0011409)1.78081584
134Ragged-red muscle fibers (HP:0003200)1.78072860
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76553892
136Exercise intolerance (HP:0003546)1.76203885
137Hepatic necrosis (HP:0002605)1.75019747
138Loss of speech (HP:0002371)1.73984042
139Tarsal synostosis (HP:0008368)1.70864930
140Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.70666634
141Achilles tendon contracture (HP:0001771)1.69300368
142Lower limb amyotrophy (HP:0007210)1.66451662
143Increased density of long bones (HP:0006392)1.65571438
144Short palpebral fissure (HP:0012745)1.57691490
145Synostosis involving bones of the feet (HP:0009140)1.54211679
146Synostosis involving bones of the lower limbs (HP:0009138)1.54211679
147Adducted thumb (HP:0001181)1.54102045
148Abnormality of the Achilles tendon (HP:0005109)1.52174927
149Congenital hip dislocation (HP:0001374)1.51091210
150Aplasia of the musculature (HP:0100854)1.49223769
151Cholelithiasis (HP:0001081)1.43944694
152Webbed neck (HP:0000465)1.43682118
153Breech presentation (HP:0001623)1.42092869
154Stridor (HP:0010307)1.41918572
155Ventricular tachycardia (HP:0004756)1.39991310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.64078406
2TTN6.19781022
3PHKG15.11746439
4PHKG25.11746439
5NME14.27532022
6PIK3CG4.26477792
7RIPK43.43771435
8MAP2K32.89694533
9MUSK2.60469049
10IRAK32.53923496
11TLK12.45145991
12TAOK32.35248061
13TRIB32.31775015
14NEK12.27853093
15PINK12.22899184
16MAP3K72.10491071
17IKBKB2.04472381
18TBK11.92068407
19MST41.90443155
20MAP3K141.77997292
21PDK41.75974156
22PDK31.75974156
23MAP4K11.73807626
24MAPK121.71249312
25TXK1.69038440
26ZAP701.68421168
27TESK21.64699524
28DMPK1.62144243
29NME21.57830641
30MAP2K61.53305064
31MAP2K41.53059972
32PIK3CA1.52312868
33IRAK41.47124170
34GRK61.45877258
35BMPR21.43844305
36CSF1R1.42787489
37BCKDK1.39673664
38SYK1.39672122
39BLK1.35487736
40MOS1.34485924
41BTK1.33527563
42IKBKE1.32450941
43MYLK1.28317952
44MAP3K121.24886279
45ADRBK21.19206509
46PDK21.09822029
47MAPKAPK31.04341704
48ARAF1.03089309
49VRK21.00375316
50TYK20.99893536
51MATK0.99644892
52GRK70.97658150
53MARK30.96900287
54TNK20.96637529
55SIK30.95327736
56LYN0.92880204
57FGR0.92321334
58HCK0.91073809
59ERN10.90435542
60TEC0.90208859
61DAPK20.90135982
62CSK0.89059590
63FES0.86498706
64MAP3K30.85947258
65MAP4K20.85795009
66TESK10.85620809
67NEK90.84795822
68PKN20.82229997
69PRKAA20.76376084
70DAPK10.75368240
71MAP2K20.74491201
72JAK30.73869996
73AKT20.73205856
74TAOK20.72845168
75PRKAA10.72400259
76ABL20.72346537
77TRPM70.72278191
78ERBB30.71405689
79DAPK30.70767499
80EEF2K0.69042542
81KIT0.64968563
82CDK80.64870141
83MAPK110.64680752
84ILK0.63100955
85TAOK10.60206164
86STK240.56948543
87PAK10.56114622
88ZAK0.55194194
89LCK0.55081535
90CAMK2G0.54665949
91EIF2AK10.53157089
92PRPF4B0.52028548
93MAP3K110.51922968
94MAP2K10.51809677
95GRK50.51455652
96CHUK0.49980222
97ITK0.49761517
98JAK10.49585729
99EPHB10.46793403
100ACVR1B0.46526555
101MAP3K130.44186297
102RIPK10.43925278
103LIMK10.42936531
104HIPK20.40511290
105IRAK10.40211598
106MAP3K100.38442614
107IRAK20.38006380
108PTK60.35296097
109STK160.34794725
110KSR20.34570588
111SIK20.32282812
112JAK20.30344906
113MAP3K10.29478574
114SGK10.29453043
115MAP3K50.28965270
116SIK10.28384924
117RPS6KA30.28036161
118PRKG10.27542194
119PRKACB0.27329931
120MAPK70.27082861
121DYRK1B0.25283108
122MAP3K60.22003462
123MAPK40.21822815
124TGFBR20.21372989
125ROCK10.20538355
126PDPK10.18725815
127PDK10.18081307
128PKN10.17516252
129PRKACA0.16455761
130LATS10.15250616
131LRRK20.14521728
132TIE10.13908500
133CCNB10.12079002
134CAMK1G0.10910550
135PAK60.10668226
136PTK2B0.09930041
137ICK0.09894455
138KSR10.09684719
139MTOR0.09446853
140RPS6KB20.08263866
141MAPK100.07836073
142PRKD10.07426992
143PIM20.07159618
144RPS6KA10.06864402
145MAP3K90.06757767
146ROCK20.06513261
147FGFR10.06451619
148BMX0.05810519
149CDK190.05245046
150CAMK2D0.04689586
151MAPK80.03939088
152CDK60.03914296
153PAK40.03435650
154CDK140.01901993
155CDK150.01201369
156LATS20.01171591
157MAPK90.00893104
158CDK11A0.00746170
159PRKACG0.00368022
160RPS6KA20.00019322
161CDK18-0.0116815
162CAMK2A-0.0089907
163SGK3-0.0077187
164CSNK1D-0.0065341
165STK11-0.0030809

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.71078348
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.17895841
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.15794312
4Dilated cardiomyopathy_Homo sapiens_hsa054143.85993331
5Cardiac muscle contraction_Homo sapiens_hsa042603.79793213
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.20427702
7Asthma_Homo sapiens_hsa053103.10537730
8Allograft rejection_Homo sapiens_hsa053303.02120367
9Starch and sucrose metabolism_Homo sapiens_hsa005002.88608311
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.88396994
11Graft-versus-host disease_Homo sapiens_hsa053322.68403429
12Autoimmune thyroid disease_Homo sapiens_hsa053202.62931750
13Oxytocin signaling pathway_Homo sapiens_hsa049212.51850722
14Rheumatoid arthritis_Homo sapiens_hsa053232.50548025
15Glucagon signaling pathway_Homo sapiens_hsa049222.42723355
16Circadian rhythm_Homo sapiens_hsa047102.38774165
17Insulin signaling pathway_Homo sapiens_hsa049102.32596744
18Type I diabetes mellitus_Homo sapiens_hsa049402.30254052
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27103862
20Other glycan degradation_Homo sapiens_hsa005112.17104250
21Leishmaniasis_Homo sapiens_hsa051402.12956150
22Carbon metabolism_Homo sapiens_hsa012002.06597892
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.04142581
24Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01087617
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.99720627
26Insulin resistance_Homo sapiens_hsa049311.97605263
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.96388275
28Osteoclast differentiation_Homo sapiens_hsa043801.95912944
29Staphylococcus aureus infection_Homo sapiens_hsa051501.95373488
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94741331
31Propanoate metabolism_Homo sapiens_hsa006401.94491453
32Lysosome_Homo sapiens_hsa041421.94357775
33Calcium signaling pathway_Homo sapiens_hsa040201.81662299
34Hematopoietic cell lineage_Homo sapiens_hsa046401.80274948
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78805878
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77219801
37Legionellosis_Homo sapiens_hsa051341.74693483
38Antigen processing and presentation_Homo sapiens_hsa046121.74301215
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71355670
40Sulfur metabolism_Homo sapiens_hsa009201.70313593
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70256290
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.69606900
43Galactose metabolism_Homo sapiens_hsa000521.69589517
44AMPK signaling pathway_Homo sapiens_hsa041521.68940535
45Collecting duct acid secretion_Homo sapiens_hsa049661.68239517
46Tuberculosis_Homo sapiens_hsa051521.64842463
47Parkinsons disease_Homo sapiens_hsa050121.63302884
48Fructose and mannose metabolism_Homo sapiens_hsa000511.55180967
49Alzheimers disease_Homo sapiens_hsa050101.53098215
50Tight junction_Homo sapiens_hsa045301.51832754
51Primary immunodeficiency_Homo sapiens_hsa053401.51511539
52Biosynthesis of amino acids_Homo sapiens_hsa012301.49202967
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44692138
54Viral myocarditis_Homo sapiens_hsa054161.42174901
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40994137
56Malaria_Homo sapiens_hsa051441.39657800
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34099306
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32853187
59TNF signaling pathway_Homo sapiens_hsa046681.32285270
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26658697
61Toxoplasmosis_Homo sapiens_hsa051451.25994678
62Oxidative phosphorylation_Homo sapiens_hsa001901.25070973
63Phagosome_Homo sapiens_hsa041451.24888509
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24533871
65Pyruvate metabolism_Homo sapiens_hsa006201.24525823
66Pertussis_Homo sapiens_hsa051331.23527733
67Focal adhesion_Homo sapiens_hsa045101.21759050
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.18690879
69Vascular smooth muscle contraction_Homo sapiens_hsa042701.17052091
70Proteasome_Homo sapiens_hsa030501.11647369
71B cell receptor signaling pathway_Homo sapiens_hsa046621.10909776
72GnRH signaling pathway_Homo sapiens_hsa049121.08153815
73Arginine and proline metabolism_Homo sapiens_hsa003301.07553583
74Fatty acid degradation_Homo sapiens_hsa000711.04682964
75Shigellosis_Homo sapiens_hsa051311.01672782
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01320682
77Chemokine signaling pathway_Homo sapiens_hsa040621.00393334
78FoxO signaling pathway_Homo sapiens_hsa040681.00215048
79Influenza A_Homo sapiens_hsa051640.99449863
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.98172982
81Gastric acid secretion_Homo sapiens_hsa049710.97987154
82T cell receptor signaling pathway_Homo sapiens_hsa046600.97691660
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97527505
84Herpes simplex infection_Homo sapiens_hsa051680.96820247
85Pentose phosphate pathway_Homo sapiens_hsa000300.96562848
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91308977
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90716445
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89333477
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88663522
90HIF-1 signaling pathway_Homo sapiens_hsa040660.88601410
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84198170
92Arachidonic acid metabolism_Homo sapiens_hsa005900.83852642
93MAPK signaling pathway_Homo sapiens_hsa040100.80656194
94Fatty acid elongation_Homo sapiens_hsa000620.79079550
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78531301
96mTOR signaling pathway_Homo sapiens_hsa041500.77175510
97Renin secretion_Homo sapiens_hsa049240.76205245
98Apoptosis_Homo sapiens_hsa042100.75736604
99Glutathione metabolism_Homo sapiens_hsa004800.75591412
100VEGF signaling pathway_Homo sapiens_hsa043700.75370136
101Regulation of autophagy_Homo sapiens_hsa041400.74472041
102Measles_Homo sapiens_hsa051620.73687248
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.72270250
104Fatty acid metabolism_Homo sapiens_hsa012120.70047622
105Platelet activation_Homo sapiens_hsa046110.64709642
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61800466
107Huntingtons disease_Homo sapiens_hsa050160.60981913
108Epstein-Barr virus infection_Homo sapiens_hsa051690.60831950
109Insulin secretion_Homo sapiens_hsa049110.55937257
110Arginine biosynthesis_Homo sapiens_hsa002200.53976394
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53710235
112African trypanosomiasis_Homo sapiens_hsa051430.53333764
113Proteoglycans in cancer_Homo sapiens_hsa052050.51846136
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.48152788
115Vibrio cholerae infection_Homo sapiens_hsa051100.47293760
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46464317
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44903948
118Amoebiasis_Homo sapiens_hsa051460.44662675
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42997541
120Endocytosis_Homo sapiens_hsa041440.42590974
121Systemic lupus erythematosus_Homo sapiens_hsa053220.42470144
122Nitrogen metabolism_Homo sapiens_hsa009100.42142449
123Long-term depression_Homo sapiens_hsa047300.41223133
124Cholinergic synapse_Homo sapiens_hsa047250.36916170
125Mineral absorption_Homo sapiens_hsa049780.35410201
126Renal cell carcinoma_Homo sapiens_hsa052110.33762634
127Adherens junction_Homo sapiens_hsa045200.33701683
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33650885
129Fatty acid biosynthesis_Homo sapiens_hsa000610.33543939
130Type II diabetes mellitus_Homo sapiens_hsa049300.32738488
131Hepatitis C_Homo sapiens_hsa051600.32402425
132Sphingolipid metabolism_Homo sapiens_hsa006000.32286875
133Hepatitis B_Homo sapiens_hsa051610.31918814
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30523754
135Circadian entrainment_Homo sapiens_hsa047130.29013217
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28530774
137PPAR signaling pathway_Homo sapiens_hsa033200.26608372
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25217236
139Prolactin signaling pathway_Homo sapiens_hsa049170.25013390
140Long-term potentiation_Homo sapiens_hsa047200.23790015
141Renin-angiotensin system_Homo sapiens_hsa046140.23258221
142ECM-receptor interaction_Homo sapiens_hsa045120.23177819
143Tryptophan metabolism_Homo sapiens_hsa003800.22058514
144beta-Alanine metabolism_Homo sapiens_hsa004100.19902482
145Melanogenesis_Homo sapiens_hsa049160.19661580
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19181046
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.18220291
148Olfactory transduction_Homo sapiens_hsa047400.17952873
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16715474
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16693780
151Purine metabolism_Homo sapiens_hsa002300.14393306
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14308618
153Glioma_Homo sapiens_hsa052140.13594478
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12743534
155Chronic myeloid leukemia_Homo sapiens_hsa052200.12697663
156Salivary secretion_Homo sapiens_hsa049700.11388163
157Acute myeloid leukemia_Homo sapiens_hsa052210.11127238
158Butanoate metabolism_Homo sapiens_hsa006500.11031543
159Sulfur relay system_Homo sapiens_hsa041220.09353950
160Gap junction_Homo sapiens_hsa045400.07619728
161Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06801540
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06500349
163Phenylalanine metabolism_Homo sapiens_hsa003600.06388076
164Bladder cancer_Homo sapiens_hsa052190.06017813
165Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04856044
166cAMP signaling pathway_Homo sapiens_hsa040240.04082848
167Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.03803249
168Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03328646
169Salmonella infection_Homo sapiens_hsa051320.03241805

Most similar genes based on co-expression Upload to Enrichr

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