JMJD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.09836829
2daunorubicin metabolic process (GO:0044597)9.09836829
3polyketide metabolic process (GO:0030638)9.09836829
4protein localization to kinetochore (GO:0034501)6.16856004
5aminoglycoside antibiotic metabolic process (GO:0030647)5.85515437
6negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.80251352
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.68454061
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.55722380
9maintenance of protein location in nucleus (GO:0051457)5.53278549
10somite rostral/caudal axis specification (GO:0032525)5.45008656
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.44253708
12RNA destabilization (GO:0050779)5.36816712
13negative regulation of epidermis development (GO:0045683)5.35575363
14regulation of telomere maintenance via telomerase (GO:0032210)5.29082798
15rRNA transcription (GO:0009303)5.19785369
16negative regulation of DNA-templated transcription, elongation (GO:0032785)5.16764608
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.02090184
18regulation of response to osmotic stress (GO:0047484)4.92460458
19histone H4-K5 acetylation (GO:0043981)4.90632753
20histone H4-K8 acetylation (GO:0043982)4.90632753
21negative regulation of telomerase activity (GO:0051974)4.85993382
22mitotic sister chromatid segregation (GO:0000070)4.82388931
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.75530338
24DNA replication checkpoint (GO:0000076)4.75272137
25rRNA methylation (GO:0031167)4.74581103
26histone H4-K12 acetylation (GO:0043983)4.73126222
27protein localization to chromosome, centromeric region (GO:0071459)4.69970240
28rRNA modification (GO:0000154)4.62094205
29viral transcription (GO:0019083)4.52628517
30DNA replication-dependent nucleosome organization (GO:0034723)4.49145862
31DNA replication-dependent nucleosome assembly (GO:0006335)4.49145862
32regulation of translation in response to stress (GO:0043555)4.43586694
33formation of translation preinitiation complex (GO:0001731)4.41267960
34cytidine deamination (GO:0009972)4.35019482
35cytidine metabolic process (GO:0046087)4.35019482
36cytidine catabolic process (GO:0006216)4.35019482
37muscle organ morphogenesis (GO:0048644)4.32484543
38negative regulation of telomere maintenance (GO:0032205)4.29536726
39ribosomal small subunit assembly (GO:0000028)4.28320391
40negative regulation of epidermal cell differentiation (GO:0045605)4.27211807
41heterochromatin organization (GO:0070828)4.22758217
42regulation of MHC class I biosynthetic process (GO:0045343)4.21675581
43cullin deneddylation (GO:0010388)4.16689433
44regulation of apoptotic process involved in morphogenesis (GO:1902337)4.14561454
45translational termination (GO:0006415)4.13799932
46interferon-gamma production (GO:0032609)4.06520907
47notochord development (GO:0030903)4.05694981
48cotranslational protein targeting to membrane (GO:0006613)4.00859141
49sister chromatid segregation (GO:0000819)4.00230061
50regulation of cilium movement (GO:0003352)3.99484104
51positive regulation of DNA-dependent DNA replication (GO:2000105)3.96728097
52positive regulation of gamma-delta T cell activation (GO:0046645)3.92877598
53ribosome biogenesis (GO:0042254)3.89332830
54nuclear pore complex assembly (GO:0051292)3.88546097
55nucleoside transmembrane transport (GO:1901642)3.87875569
56hypothalamus development (GO:0021854)3.87454713
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.85009201
58protein targeting to ER (GO:0045047)3.81962107
59protein deneddylation (GO:0000338)3.78051207
60translational elongation (GO:0006414)3.77915186
61regulation of chronic inflammatory response (GO:0002676)3.72811554
62quinone metabolic process (GO:1901661)3.72648082
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68999669
64DNA damage response, detection of DNA damage (GO:0042769)3.67879485
65ribosomal small subunit biogenesis (GO:0042274)3.66483134
66chromatin assembly (GO:0031497)3.66268916
67protein localization to endoplasmic reticulum (GO:0070972)3.65665061
68deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.60543539
69nuclear pore organization (GO:0006999)3.60191273
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.60159506
71histone H4-K16 acetylation (GO:0043984)3.58778059
72DNA unwinding involved in DNA replication (GO:0006268)3.56665326
73primitive streak formation (GO:0090009)3.56136722
74chaperone-mediated protein transport (GO:0072321)3.55862535
75sequestering of actin monomers (GO:0042989)3.54591729
76pseudouridine synthesis (GO:0001522)3.53511551
77phenol-containing compound catabolic process (GO:0019336)3.52491309
78nonribosomal peptide biosynthetic process (GO:0019184)3.51638016
79mitotic chromosome condensation (GO:0007076)3.51130900
80glutathione biosynthetic process (GO:0006750)3.50170966
81hormone catabolic process (GO:0042447)3.49172523
82tolerance induction (GO:0002507)3.45743113
83GDP-mannose metabolic process (GO:0019673)3.44397656
84viral life cycle (GO:0019058)3.40899030
85DNA ligation (GO:0006266)3.38479553
86transcription from mitochondrial promoter (GO:0006390)3.37225796
87positive regulation of translational initiation (GO:0045948)3.34460750
88regulation of posttranscriptional gene silencing (GO:0060147)3.34149569
89regulation of gene silencing by miRNA (GO:0060964)3.34149569
90regulation of gene silencing by RNA (GO:0060966)3.34149569
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32415605
92DNA duplex unwinding (GO:0032508)3.30795516
93valine metabolic process (GO:0006573)3.30090197
94regulation of telomerase activity (GO:0051972)3.29937788
95DNA replication initiation (GO:0006270)3.29483191
96intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.29478761
97DNA geometric change (GO:0032392)3.27297185
98ribonucleoprotein complex biogenesis (GO:0022613)3.27089853
99kinetochore assembly (GO:0051382)3.25529072
100ATP synthesis coupled proton transport (GO:0015986)3.25125626
101energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25125626
102cell fate commitment involved in formation of primary germ layer (GO:0060795)3.23421794
103regulation of gamma-delta T cell activation (GO:0046643)3.18866765
104response to dietary excess (GO:0002021)3.18711855
105cellular response to nicotine (GO:0071316)3.15997794
106branching involved in mammary gland duct morphogenesis (GO:0060444)3.14217871
107pore complex assembly (GO:0046931)3.13311663
108iron-sulfur cluster assembly (GO:0016226)3.12334042
109metallo-sulfur cluster assembly (GO:0031163)3.12334042
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11719152
111positive regulation of monocyte chemotaxis (GO:0090026)3.11297010
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10491561
113histone H2A acetylation (GO:0043968)3.09300022
114purine nucleotide salvage (GO:0032261)3.08736382
115sulfur amino acid catabolic process (GO:0000098)3.08601272
116cellular protein complex disassembly (GO:0043624)3.08213358
117regulation of activation of Janus kinase activity (GO:0010533)3.07852975
118regulation of telomere maintenance (GO:0032204)3.07554322
119DNA deamination (GO:0045006)3.03441944
120coenzyme catabolic process (GO:0009109)3.03292786
121maintenance of protein localization in organelle (GO:0072595)3.03206218
122pre-miRNA processing (GO:0031054)3.01582182
123purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.00824810
124regulation of mononuclear cell migration (GO:0071675)3.00107972
125nucleoside transport (GO:0015858)2.98682140
126protein neddylation (GO:0045116)2.97058507
127cellular response to arsenic-containing substance (GO:0071243)2.95643068
128negative regulation by host of viral transcription (GO:0043922)2.95497053
129apoptotic DNA fragmentation (GO:0006309)2.95344390
130establishment of viral latency (GO:0019043)2.95058038
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93301931
132negative regulation of gene silencing (GO:0060969)2.91523602
133RNA stabilization (GO:0043489)2.91432163
134mRNA stabilization (GO:0048255)2.91432163
135regulation of gamma-delta T cell differentiation (GO:0045586)2.90713899
136pteridine-containing compound biosynthetic process (GO:0042559)2.89680541
137retinoic acid receptor signaling pathway (GO:0048384)2.89184093
138purine nucleobase biosynthetic process (GO:0009113)2.88041753
139chemokine-mediated signaling pathway (GO:0070098)2.86613036
140intestinal epithelial cell development (GO:0060576)2.86250501
141maternal placenta development (GO:0001893)2.86063059
142translational initiation (GO:0006413)2.85986723
143protein polyglutamylation (GO:0018095)2.85674715
144translation (GO:0006412)2.82886511
145cellular modified amino acid catabolic process (GO:0042219)2.82475680
146regulation of double-strand break repair (GO:2000779)2.82406250
147positive regulation of protein deacetylation (GO:0090312)2.82257877
148trophectodermal cell differentiation (GO:0001829)2.82208963
149purine deoxyribonucleotide catabolic process (GO:0009155)2.81691453
150negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.81678584
151mitochondrial DNA replication (GO:0006264)2.79813872
152pyrimidine ribonucleoside catabolic process (GO:0046133)2.79095439
153termination of RNA polymerase III transcription (GO:0006386)2.78934520
154transcription elongation from RNA polymerase III promoter (GO:0006385)2.78934520
155negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78858005
156positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77180441
157positive regulation of T cell apoptotic process (GO:0070234)2.75973886
158regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.73920100
159regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.71865996
160respiratory electron transport chain (GO:0022904)2.68604727
161cardiovascular system development (GO:0072358)2.68019314
162mitotic metaphase plate congression (GO:0007080)2.67402336
163histone arginine methylation (GO:0034969)2.67324622
164protein targeting to membrane (GO:0006612)2.67234717
165establishment of integrated proviral latency (GO:0075713)2.67076190
166negative regulation of interleukin-2 production (GO:0032703)2.66302104
167L-serine metabolic process (GO:0006563)2.65293366
168protein complex disassembly (GO:0043241)2.63554397
169fatty acid elongation (GO:0030497)2.63184779
170electron transport chain (GO:0022900)2.63012271
171phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.60647147
172nucleoside diphosphate catabolic process (GO:0009134)2.60572737
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.59256345
174modulation by host of symbiont transcription (GO:0052472)2.58581885
175modulation by host of viral transcription (GO:0043921)2.58581885
176nuclear-transcribed mRNA catabolic process (GO:0000956)2.51660970
177negative T cell selection (GO:0043383)2.50774460
178deoxyribose phosphate catabolic process (GO:0046386)2.49950899
179deoxyribonucleotide catabolic process (GO:0009264)2.49053037
180macromolecular complex disassembly (GO:0032984)2.48286657
181regulation of cytokine production involved in inflammatory response (GO:1900015)2.47702992
182negative thymic T cell selection (GO:0045060)2.47366935
183protein peptidyl-prolyl isomerization (GO:0000413)2.45957763
184leukocyte aggregation (GO:0070486)2.45418293
185regulation of dopamine metabolic process (GO:0042053)2.45321886
186regulation of catecholamine metabolic process (GO:0042069)2.45321886
187positive regulation of lymphocyte apoptotic process (GO:0070230)2.44523061
188response to pheromone (GO:0019236)2.44287737
189nucleobase biosynthetic process (GO:0046112)2.43071016
190regulation of chemokine-mediated signaling pathway (GO:0070099)2.41815385
191negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41811779
192regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.41594861
193nucleotide salvage (GO:0043173)2.41327566
194pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40949316
195mast cell activation (GO:0045576)2.40829542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72033618
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.82044484
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.82044484
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.82044484
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.66293040
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.24940929
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83512087
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.92484954
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.89235491
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88577428
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.84307206
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80603250
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57727070
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55685774
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.53607028
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.45097696
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.39231306
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27412494
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25347413
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.24438009
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16195695
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15340040
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.14628987
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14143443
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11011238
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08790537
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07181181
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.06623935
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00735924
30TCF3_18692474_ChIP-Seq_MESCs_Mouse1.94417615
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92862458
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.91277302
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86776297
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85415254
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82864950
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81403769
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80215586
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79150824
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75478282
40NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74163505
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72877006
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71920767
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70840826
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69646446
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.69399064
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66172272
47MYC_22102868_ChIP-Seq_BL_Human1.65753599
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62028270
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.61765165
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59007711
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58919754
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57406884
53IRF1_19129219_ChIP-ChIP_H3396_Human1.55498729
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54978766
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54868874
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.52105505
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49700505
58XRN2_22483619_ChIP-Seq_HELA_Human1.49629471
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47841700
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46545798
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45646860
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45522366
63MAF_26560356_Chip-Seq_TH2_Human1.45417687
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39375179
65FOXP3_21729870_ChIP-Seq_TREG_Human1.38932156
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37948288
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36829819
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.32614560
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32325273
70VDR_21846776_ChIP-Seq_THP-1_Human1.31668851
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30200059
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29887772
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29414004
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29008358
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28871475
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27034709
77MAF_26560356_Chip-Seq_TH1_Human1.26907593
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26534459
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25458456
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24245904
81NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23325768
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22740905
83UTX_26944678_Chip-Seq_JUKART_Human1.22160016
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19981983
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17861313
86VDR_23849224_ChIP-Seq_CD4+_Human1.17336436
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15027004
88BCL6_27268052_Chip-Seq_Bcells_Human1.14468021
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14064696
90GABP_19822575_ChIP-Seq_HepG2_Human1.13720759
91TTF2_22483619_ChIP-Seq_HELA_Human1.13278131
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13199501
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12261192
94ELK1_19687146_ChIP-ChIP_HELA_Human1.11266967
95TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10921908
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09092254
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08924193
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.08227551
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08115265
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08080768
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07580079
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07492649
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07233468
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06338813
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06237295
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.05291769
107E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04105684
108CIITA_25753668_ChIP-Seq_RAJI_Human1.04027372
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03982249
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03942100
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.03599073
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02940111
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.02922842
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02801149
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01180053
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01037691
117AR_21909140_ChIP-Seq_LNCAP_Human1.00788107
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99990985
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99799616
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99663996
121SPI1_23547873_ChIP-Seq_NB4_Human0.99090074
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98732313
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98533373
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.98244716
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97995247
126* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97309485
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.96606867
128KDM5A_27292631_Chip-Seq_BREAST_Human0.95912592
129FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95340577
130MYC_18940864_ChIP-ChIP_HL60_Human0.95038121
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94006853
132DCP1A_22483619_ChIP-Seq_HELA_Human0.93008692
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92531163
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91532822
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91088807
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.90881940
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90222738
138EGR1_19374776_ChIP-ChIP_THP-1_Human0.90208020
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85269333
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84592143
141ELK1_22589737_ChIP-Seq_MCF10A_Human0.84146936
142NANOG_16518401_ChIP-PET_MESCs_Mouse0.82958175
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82447867
144SCL_19346495_ChIP-Seq_HPC-7_Human0.82375399
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81807268
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.81601453
147NCOR1_26117541_ChIP-Seq_K562_Human0.81222185
148TP53_22127205_ChIP-Seq_IMR90_Human0.80968039
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80551157
150* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79264807
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78096151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.02300556
2MP0003011_delayed_dark_adaptation3.97806004
3MP0002254_reproductive_system_inflammat3.73428601
4MP0005671_abnormal_response_to3.71641785
5MP0004264_abnormal_extraembryonic_tissu3.62357684
6MP0004957_abnormal_blastocyst_morpholog3.45764113
7MP0008057_abnormal_DNA_replication3.41580556
8MP0003890_abnormal_embryonic-extraembry3.34250077
9MP0005075_abnormal_melanosome_morpholog3.20910347
10MP0005499_abnormal_olfactory_system3.13342629
11MP0005394_taste/olfaction_phenotype3.13342629
12MP0010352_gastrointestinal_tract_polyps2.47260413
13MP0003122_maternal_imprinting2.39125538
14MP0003077_abnormal_cell_cycle2.36169762
15MP0003763_abnormal_thymus_physiology2.35410433
16MP0004858_abnormal_nervous_system2.24602053
17MP0006035_abnormal_mitochondrial_morpho2.19639448
18MP0002332_abnormal_exercise_endurance2.17002613
19MP0003111_abnormal_nucleus_morphology2.07075432
20MP0002653_abnormal_ependyma_morphology2.02667257
21MP0009697_abnormal_copulation2.01163044
22MP0003121_genomic_imprinting1.99531611
23MP0002148_abnormal_hypersensitivity_rea1.98992581
24MP0010030_abnormal_orbit_morphology1.97693178
25MP0010094_abnormal_chromosome_stability1.94942207
26MP0005380_embryogenesis_phenotype1.91653379
27MP0001672_abnormal_embryogenesis/_devel1.91653379
28MP0003705_abnormal_hypodermis_morpholog1.90917636
29MP0000015_abnormal_ear_pigmentation1.88206569
30MP0005257_abnormal_intraocular_pressure1.87537742
31MP0000678_abnormal_parathyroid_gland1.86553373
32MP0002277_abnormal_respiratory_mucosa1.83768435
33MP0002396_abnormal_hematopoietic_system1.83556567
34MP0005000_abnormal_immune_tolerance1.83329259
35MP0003693_abnormal_embryo_hatching1.76515361
36MP0002088_abnormal_embryonic_growth/wei1.75906808
37MP0003984_embryonic_growth_retardation1.74735149
38MP0000350_abnormal_cell_proliferation1.73104724
39MP0003878_abnormal_ear_physiology1.68748859
40MP0005377_hearing/vestibular/ear_phenot1.68748859
41MP0006072_abnormal_retinal_apoptosis1.67689738
42MP0002723_abnormal_immune_serum1.64641937
43MP0003880_abnormal_central_pattern1.63289685
44MP0003123_paternal_imprinting1.63266573
45MP0002405_respiratory_system_inflammati1.62463672
46MP0005451_abnormal_body_composition1.62351187
47MP0002132_abnormal_respiratory_system1.61766075
48MP0001293_anophthalmia1.58320710
49MP0003938_abnormal_ear_development1.57549942
50MP0008789_abnormal_olfactory_epithelium1.56706908
51MP0002095_abnormal_skin_pigmentation1.56552185
52MP0001800_abnormal_humoral_immune1.56424593
53MP0002127_abnormal_cardiovascular_syste1.55491004
54MP0005379_endocrine/exocrine_gland_phen1.51636513
55MP0005058_abnormal_lysosome_morphology1.51309644
56MP0001819_abnormal_immune_cell1.51264188
57MP0001790_abnormal_immune_system1.50969925
58MP0005387_immune_system_phenotype1.50969925
59MP0002452_abnormal_antigen_presenting1.49705599
60MP0008007_abnormal_cellular_replicative1.48125712
61MP0002420_abnormal_adaptive_immunity1.47737084
62MP0003436_decreased_susceptibility_to1.46333336
63MP0000685_abnormal_immune_system1.46190278
64MP0005253_abnormal_eye_physiology1.46004301
65MP0001849_ear_inflammation1.45642296
66MP0003136_yellow_coat_color1.43287266
67MP0004147_increased_porphyrin_level1.43233667
68MP0008932_abnormal_embryonic_tissue1.43160322
69MP0002932_abnormal_joint_morphology1.42103260
70MP0000490_abnormal_crypts_of1.40610380
71MP0009840_abnormal_foam_cell1.37664084
72MP0002085_abnormal_embryonic_tissue1.37124002
73MP0004133_heterotaxia1.34442721
74MP0002086_abnormal_extraembryonic_tissu1.33684472
75MP0001727_abnormal_embryo_implantation1.33587206
76MP0002163_abnormal_gland_morphology1.33566601
77MP0006082_CNS_inflammation1.33181620
78MP0002092_abnormal_eye_morphology1.29925686
79MP0001730_embryonic_growth_arrest1.29566916
80MP0001661_extended_life_span1.29209937
81MP0002398_abnormal_bone_marrow1.28334254
82MP0001873_stomach_inflammation1.26207765
83MP0005266_abnormal_metabolism1.25845598
84MP0000465_gastrointestinal_hemorrhage1.25086077
85MP0000716_abnormal_immune_system1.24845754
86MP0003315_abnormal_perineum_morphology1.22871045
87MP0008961_abnormal_basal_metabolism1.22330559
88MP0000313_abnormal_cell_death1.21514054
89MP0005310_abnormal_salivary_gland1.20996093
90MP0004947_skin_inflammation1.20909618
91MP0008995_early_reproductive_senescence1.19593129
92MP0002084_abnormal_developmental_patter1.19332405
93MP0000049_abnormal_middle_ear1.18066146
94MP0003786_premature_aging1.17928353
95MP0003183_abnormal_peptide_metabolism1.17294342
96MP0005501_abnormal_skin_physiology1.13510910
97MP0001697_abnormal_embryo_size1.12561548
98MP0000762_abnormal_tongue_morphology1.11984438
99MP0008872_abnormal_physiological_respon1.09672539
100MP0008058_abnormal_DNA_repair1.08623360
101MP0004197_abnormal_fetal_growth/weight/1.08010260
102MP0001853_heart_inflammation1.07095410
103MP0005025_abnormal_response_to1.06644190
104MP0009785_altered_susceptibility_to1.05467256
105MP0002080_prenatal_lethality1.05236228
106MP0002638_abnormal_pupillary_reflex1.04066194
107MP0004381_abnormal_hair_follicle1.02638739
108MP0002233_abnormal_nose_morphology1.01675487
109MP0010155_abnormal_intestine_physiology1.01254178
110MP0004883_abnormal_blood_vessel1.00488717
111MP0001764_abnormal_homeostasis1.00442634
112MP0002114_abnormal_axial_skeleton1.00137055
113MP0001348_abnormal_lacrimal_gland0.99354824
114MP0008875_abnormal_xenobiotic_pharmacok0.98568001
115MP0002090_abnormal_vision0.97689113
116MP0003119_abnormal_digestive_system0.96551970
117MP0002419_abnormal_innate_immunity0.95235118
118MP0009765_abnormal_xenobiotic_induced0.93521756
119MP0002736_abnormal_nociception_after0.92725128
120MP0009379_abnormal_foot_pigmentation0.92506042
121MP0000428_abnormal_craniofacial_morphol0.92198667
122MP0004043_abnormal_pH_regulation0.91465806
123MP0002970_abnormal_white_adipose0.90972904
124MP0001919_abnormal_reproductive_system0.90262335
125MP0003806_abnormal_nucleotide_metabolis0.89276929
126MP0001986_abnormal_taste_sensitivity0.85139536
127MP0001845_abnormal_inflammatory_respons0.84693015
128MP0008770_decreased_survivor_rate0.84681670
129MP0003453_abnormal_keratinocyte_physiol0.84240275
130MP0002751_abnormal_autonomic_nervous0.83966575
131MP0005023_abnormal_wound_healing0.83752596
132MP0000432_abnormal_head_morphology0.83298641
133MP0000358_abnormal_cell_content/0.83053404
134MP0003935_abnormal_craniofacial_develop0.82934145
135MP0002019_abnormal_tumor_incidence0.82503027
136MP0003186_abnormal_redox_activity0.81240171
137MP0003724_increased_susceptibility_to0.79420125
138MP0000566_synostosis0.78601620
139MP0002837_dystrophic_cardiac_calcinosis0.77795848
140MP0009764_decreased_sensitivity_to0.76798320
141MP0005391_vision/eye_phenotype0.76443964
142MP0002722_abnormal_immune_system0.76292142
143MP0008469_abnormal_protein_level0.76059460
144MP0001346_abnormal_lacrimal_gland0.74192120
145MP0002938_white_spotting0.73955515
146MP0004782_abnormal_surfactant_physiolog0.73736318
147MP0005167_abnormal_blood-brain_barrier0.73119864
148MP0002925_abnormal_cardiovascular_devel0.72994442
149MP0000689_abnormal_spleen_morphology0.72483887
150MP0006036_abnormal_mitochondrial_physio0.71580924
151MP0003137_abnormal_impulse_conducting0.71330147
152MP0005508_abnormal_skeleton_morphology0.71284674
153MP0000750_abnormal_muscle_regeneration0.70513987
154MP0001286_abnormal_eye_development0.69895569
155MP0000858_altered_metastatic_potential0.68932994
156MP0003755_abnormal_palate_morphology0.68800169
157MP0002098_abnormal_vibrissa_morphology0.63821966
158MP0002111_abnormal_tail_morphology0.61552696
159MP0000703_abnormal_thymus_morphology0.60491203
160MP0003937_abnormal_limbs/digits/tail_de0.59599914
161MP0005384_cellular_phenotype0.58955256
162MP0000372_irregular_coat_pigmentation0.57035441
163MP0002429_abnormal_blood_cell0.55742258
164MP0009333_abnormal_splenocyte_physiolog0.55669677
165MP0005197_abnormal_uvea_morphology0.55539197
166MP0002116_abnormal_craniofacial_bone0.55404868

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.09577087
2Multiple enchondromatosis (HP:0005701)5.81407731
3Hypochromic microcytic anemia (HP:0004840)5.10267099
4Hepatoblastoma (HP:0002884)5.00871694
5Severe combined immunodeficiency (HP:0004430)4.97738186
6Rib fusion (HP:0000902)4.55557262
7Ependymoma (HP:0002888)4.38064649
8Abnormality of the lower motor neuron (HP:0002366)4.20273713
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19549812
10B lymphocytopenia (HP:0010976)3.91173036
11Oral leukoplakia (HP:0002745)3.82270366
12Chromsome breakage (HP:0040012)3.68239408
13Nephroblastoma (Wilms tumor) (HP:0002667)3.65257669
14Partial duplication of thumb phalanx (HP:0009944)3.59826332
15Rhabdomyosarcoma (HP:0002859)3.53238064
16Neoplasm of striated muscle (HP:0009728)3.53130778
17Rectal fistula (HP:0100590)3.50461979
18Rectovaginal fistula (HP:0000143)3.50461979
19Reticulocytopenia (HP:0001896)3.46834902
20Recurrent abscess formation (HP:0002722)3.40630969
21Embryonal renal neoplasm (HP:0011794)3.39954425
22Panhypogammaglobulinemia (HP:0003139)3.34755324
23Abnormal lung lobation (HP:0002101)3.33183916
24Trismus (HP:0000211)3.30186078
25Ragged-red muscle fibers (HP:0003200)3.28407807
26Abnormality of B cell number (HP:0010975)3.25941521
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23825864
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23825864
29Fused cervical vertebrae (HP:0002949)3.14679994
30Aplasia/hypoplasia of the humerus (HP:0006507)3.14406172
31Partial duplication of the phalanx of hand (HP:0009999)3.12890534
32Intestinal fistula (HP:0100819)3.11177677
33Vaginal fistula (HP:0004320)3.10987635
34Bifid tongue (HP:0010297)3.09911556
35Anomalous pulmonary venous return (HP:0010772)2.99971882
36Acute necrotizing encephalopathy (HP:0006965)2.98019334
37Short humerus (HP:0005792)2.97973620
38Hypoplasia of the fovea (HP:0007750)2.97361108
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.97361108
40Testicular atrophy (HP:0000029)2.93467309
41Abnormality of the astrocytes (HP:0100707)2.90302644
42Astrocytoma (HP:0009592)2.90302644
43Mitochondrial inheritance (HP:0001427)2.89443477
44Abnormal mitochondria in muscle tissue (HP:0008316)2.87904743
45Abnormal cartilage morphology (HP:0002763)2.85149361
46Reduced antithrombin III activity (HP:0001976)2.81786875
47Abnormality of the salivary glands (HP:0010286)2.79803188
48Preauricular skin tag (HP:0000384)2.75912162
49Meckel diverticulum (HP:0002245)2.75261864
50Autoimmune hemolytic anemia (HP:0001890)2.71520753
51Microretrognathia (HP:0000308)2.68103936
52Acute encephalopathy (HP:0006846)2.64446908
53Amyotrophic lateral sclerosis (HP:0007354)2.63109982
54Thyroiditis (HP:0100646)2.62865840
55Absent septum pellucidum (HP:0001331)2.62775611
56Progressive muscle weakness (HP:0003323)2.62745021
57Abnormality of cells of the erythroid lineage (HP:0012130)2.61555218
58Hypochromic anemia (HP:0001931)2.60982366
59Diastasis recti (HP:0001540)2.60963943
60Hyperinsulinemic hypoglycemia (HP:0000825)2.60088374
61Abnormal number of erythroid precursors (HP:0012131)2.59671882
62Maternal diabetes (HP:0009800)2.59644315
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59323361
64Hepatocellular necrosis (HP:0001404)2.58212721
65Abnormality of the ileum (HP:0001549)2.57756517
66Abnormality of lateral ventricle (HP:0030047)2.56727097
67Hypoplasia of the thymus (HP:0000778)2.55836688
68Abnormality of eosinophils (HP:0001879)2.54883610
69Rough bone trabeculation (HP:0100670)2.54661628
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.53765809
71Stomatitis (HP:0010280)2.52922064
72Myokymia (HP:0002411)2.51951398
73Abnormality of the pulmonary veins (HP:0011718)2.51149880
74Prominent metopic ridge (HP:0005487)2.50874050
75Abnormality of the metopic suture (HP:0005556)2.50098630
76Increased IgE level (HP:0003212)2.48690153
77Increased intramyocellular lipid droplets (HP:0012240)2.42585000
78Glossoptosis (HP:0000162)2.41693153
79Entropion (HP:0000621)2.40657730
80Duplication of thumb phalanx (HP:0009942)2.39982546
81Erythroderma (HP:0001019)2.39691297
82Skin tags (HP:0010609)2.39268015
83Impulsivity (HP:0100710)2.38665141
84Increased hepatocellular lipid droplets (HP:0006565)2.37334509
85Supernumerary spleens (HP:0009799)2.36083296
86Recurrent bacterial skin infections (HP:0005406)2.36071240
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.35855785
88Septo-optic dysplasia (HP:0100842)2.35517410
89Aplastic anemia (HP:0001915)2.34963163
90Increased CSF lactate (HP:0002490)2.34873294
91Combined immunodeficiency (HP:0005387)2.33483603
923-Methylglutaconic aciduria (HP:0003535)2.30562419
93Pendular nystagmus (HP:0012043)2.29958622
94Abnormality of the phalanges of the hallux (HP:0010057)2.28103484
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27893296
96Aplasia/Hypoplasia of the sternum (HP:0006714)2.27878148
97Recurrent fungal infections (HP:0002841)2.27790121
98Eczematoid dermatitis (HP:0000976)2.26210768
99Horizontal nystagmus (HP:0000666)2.25977705
100Basal cell carcinoma (HP:0002671)2.25423115
101Abnormal umbilical cord blood vessels (HP:0011403)2.22143309
102Single umbilical artery (HP:0001195)2.22143309
103Abnormality of the fetal cardiovascular system (HP:0010948)2.22143309
104Periauricular skin pits (HP:0100277)2.21619663
105Preauricular pit (HP:0004467)2.21619663
106Granulocytopenia (HP:0001913)2.21295543
107Short 5th finger (HP:0009237)2.21232253
108Aplasia/Hypoplasia of the thymus (HP:0010515)2.19758006
109Missing ribs (HP:0000921)2.19536247
110Tetraplegia (HP:0002445)2.19202325
111Lactic acidosis (HP:0003128)2.17511435
112Small intestinal stenosis (HP:0012848)2.17367885
113Duodenal stenosis (HP:0100867)2.17367885
114Recurrent viral infections (HP:0004429)2.17363989
115Congenital ichthyosiform erythroderma (HP:0007431)2.16806449
116Facial cleft (HP:0002006)2.16795175
117Chronic obstructive pulmonary disease (HP:0006510)2.16649395
118Obstructive lung disease (HP:0006536)2.16649395
119Abnormality of the fovea (HP:0000493)2.15978715
120Tongue fasciculations (HP:0001308)2.15933673
121Hemivertebrae (HP:0002937)2.15882046
122Glioma (HP:0009733)2.15451603
123T lymphocytopenia (HP:0005403)2.14903195
124Increased serum pyruvate (HP:0003542)2.13646496
125Abnormality of glycolysis (HP:0004366)2.13646496
126Nasolacrimal duct obstruction (HP:0000579)2.13633055
127Microvesicular hepatic steatosis (HP:0001414)2.13284141
128Shawl scrotum (HP:0000049)2.12812592
129Generalized hypotonia (HP:0001290)2.10626555
130Villous atrophy (HP:0011473)2.10394178
131Abnormality of small intestinal villus morphology (HP:0011472)2.10394178
132Type I transferrin isoform profile (HP:0003642)2.10189592
133Atresia of the external auditory canal (HP:0000413)2.10094020
134Hepatic necrosis (HP:0002605)2.09652115
135Severe visual impairment (HP:0001141)2.09097344
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09037401
137Renal Fanconi syndrome (HP:0001994)2.09014537
138Abnormality of the umbilical cord (HP:0010881)2.08937160
139Stenosis of the external auditory canal (HP:0000402)2.08630188
140Overlapping toe (HP:0001845)2.08473679
141Eosinophilia (HP:0001880)2.08138924
142Parakeratosis (HP:0001036)2.07883873
143Large earlobe (HP:0009748)2.06636535
144IgM deficiency (HP:0002850)2.06023882
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05111725
146Spinal muscular atrophy (HP:0007269)2.04921706
147Abnormality of chromosome segregation (HP:0002916)2.04667574
148Renal duplication (HP:0000075)2.04298650
149Colitis (HP:0002583)2.04261548
150Medulloblastoma (HP:0002885)2.04166417
151Abnormal trabecular bone morphology (HP:0100671)2.03428763
152Premature ovarian failure (HP:0008209)2.02678285
153Progressive macrocephaly (HP:0004481)2.02436370
154Abnormality of the septum pellucidum (HP:0007375)2.01324962
155Hypoproteinemia (HP:0003075)2.00476307
156Abnormality of the distal phalanx of the thumb (HP:0009617)2.00421049
157Autoimmune thrombocytopenia (HP:0001973)1.99884464
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99700380
159Pustule (HP:0200039)1.99105110
160Pallor (HP:0000980)1.98865217
161Neutropenia (HP:0001875)1.98214399
162Vertebral fusion (HP:0002948)1.97423810
163Pancytopenia (HP:0001876)1.97374104
164Muscle fibrillation (HP:0010546)1.97039579
165Sparse eyelashes (HP:0000653)1.96535800
166Lipid accumulation in hepatocytes (HP:0006561)1.95386838
167Squamous cell carcinoma (HP:0002860)1.95308083
168Seborrheic dermatitis (HP:0001051)1.94613894
169Increased muscle lipid content (HP:0009058)1.93640051
170Poikiloderma (HP:0001029)1.93130136
171Abnormality of the preputium (HP:0100587)1.92947991
172Macrocytic anemia (HP:0001972)1.92719322
173Myelodysplasia (HP:0002863)1.92558981
174Malignant neoplasm of the central nervous system (HP:0100836)1.91304820
175Lymphopenia (HP:0001888)1.91212872
176Aplasia/Hypoplasia of the macula (HP:0008059)1.87671988
177Hypoplastic pelvis (HP:0008839)1.87302037
178Renal dysplasia (HP:0000110)1.86984035
179Selective tooth agenesis (HP:0001592)1.86092751
180IgG deficiency (HP:0004315)1.84586278
181Abnormality of T cell number (HP:0011839)1.83886597
182Angiofibromas (HP:0010615)1.83680220
183Adenoma sebaceum (HP:0009720)1.83680220
184Abnormalities of placenta or umbilical cord (HP:0001194)1.83275174
185Abnormality of the duodenum (HP:0002246)1.82221137
186Upper motor neuron abnormality (HP:0002127)1.81805027
187Myelomeningocele (HP:0002475)1.81166929
188Vacuolated lymphocytes (HP:0001922)1.79099177
189Loss of speech (HP:0002371)1.78646961
190Optic disc pallor (HP:0000543)1.78600307
191Ectropion (HP:0000656)1.77802094
192Abnormality of macrophages (HP:0004311)1.74361751
193Paralysis (HP:0003470)1.71246871
194Aplasia/Hypoplasia of the spleen (HP:0010451)1.70713120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.93988734
2GRK54.79446946
3GRK64.25324590
4ERN14.01901506
5CAMK1D4.01413272
6MAP3K113.65984226
7ADRBK23.18958387
8GRK13.04995640
9MAP4K22.94094625
10CCNB12.90679287
11CSF1R2.87709736
12CAMK1G2.85275128
13TTK2.71095609
14STK102.69368187
15VRK22.56562738
16TGFBR22.52854710
17PRKD32.33073978
18MAPK72.28860224
19GRK72.28561544
20TXK2.28518664
21TYRO32.27261261
22EPHB22.24996064
23CAMKK22.22821861
24PNCK2.15691174
25MATK2.07533449
26EPHA41.99204408
27MAP3K121.98991545
28MOS1.90169173
29CDK71.87062177
30BUB11.75089285
31PASK1.69924237
32STK161.62594439
33PAK41.57660302
34WNK11.55006943
35TEC1.45883755
36EPHA21.44445348
37TAOK11.39327463
38PRKG21.39098705
39PLK11.38040545
40MAP3K101.36119899
41SRPK11.33451342
42MARK31.27092972
43BTK1.26408138
44CHEK21.26159982
45WEE11.24895424
46ARAF1.24005139
47MUSK1.23751894
48IRAK31.21934216
49CAMK41.21453868
50NUAK11.17852600
51CDC71.09890363
52ZAK1.08865141
53AKT31.06858592
54HIPK21.05260429
55NEK20.99936199
56ADRBK10.95425934
57DYRK30.93249927
58MAP2K60.91596503
59MARK20.88026270
60CHEK10.87987957
61IRAK40.87895794
62AKT20.87089091
63CAMKK10.86520002
64TYK20.86076070
65LRRK20.85391143
66MAPK150.84144033
67IKBKE0.84040451
68TESK10.83979839
69EIF2AK20.82535782
70FGFR30.81367246
71NLK0.80922843
72NTRK10.79423197
73AURKA0.78040598
74LCK0.74538958
75ILK0.74479253
76ACVR1B0.74119870
77NME20.73491934
78IRAK20.72906087
79TESK20.72532299
80TBK10.71996145
81AURKB0.69905699
82MAPK120.68753031
83PRKD20.67757912
84CAMK10.67437416
85PRKCI0.67417588
86RPS6KB20.66802382
87NME10.65687340
88STK240.62490477
89FGR0.61642275
90ALK0.60985813
91CDK40.60699340
92SYK0.60023048
93ITK0.59723768
94CSK0.59368048
95PRKCQ0.59237942
96HCK0.58029647
97NEK10.57545536
98PAK10.54625700
99CDK20.54205567
100DAPK30.54142851
101FES0.53938096
102MYLK0.53497355
103TLK10.53224247
104IRAK10.52728005
105MAP2K40.51985529
106SMG10.51543088
107IKBKB0.49393561
108CLK10.49265314
109LATS20.47617214
110SIK20.47549789
111RPS6KA10.44837727
112ATR0.44825276
113DYRK20.43376798
114MTOR0.43238249
115BLK0.42824681
116MAP4K10.40517288
117ATM0.40148239
118MAP2K20.38231636
119STK40.35926429
120BRD40.35771132
121PRKCD0.35056340
122IGF1R0.33305646
123MST40.32106174
124EIF2AK10.31908168
125PRKCH0.31459715
126CDK10.31234721
127PIM20.30663743
128MAP3K70.29466528
129FLT30.29421578
130TNK20.28274872
131MAP3K80.28164775
132ERBB20.27690185
133FGFR10.26971136
134SIK10.26581093
135MAPK40.25806714
136VRK10.25642194
137CDK80.25461784
138MAPKAPK30.25017384
139KIT0.24980330
140PDK20.24478275
141MAP3K60.24385851
142PLK30.24178240
143EPHB10.24159440
144ZAP700.22722257
145ERBB30.21273292
146LYN0.21147955
147CSNK1E0.20897263
148PIM10.20038743
149BRSK10.19783319
150MAPKAPK20.19372650
151BRSK20.19257737
152STK38L0.18019832
153MELK0.17877343
154INSR0.17810388
155STK30.16056133
156CSNK2A10.15390194
157CHUK0.14682559
158BCKDK0.13204666
159CDK11A0.13066593
160MAPK10.12660756
161MAPK140.12227730
162GSK3B0.11476617
163CDK150.11281148

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.21111470
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.37611547
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.03374879
4Oxidative phosphorylation_Homo sapiens_hsa001903.45630702
5Ribosome_Homo sapiens_hsa030103.26570601
6DNA replication_Homo sapiens_hsa030303.24204102
7Fructose and mannose metabolism_Homo sapiens_hsa000512.99643860
8Parkinsons disease_Homo sapiens_hsa050122.97561170
9Protein export_Homo sapiens_hsa030602.94628283
10Mismatch repair_Homo sapiens_hsa034302.76371614
11RNA transport_Homo sapiens_hsa030132.53086197
12Huntingtons disease_Homo sapiens_hsa050162.36906048
13Galactose metabolism_Homo sapiens_hsa000522.27232525
14RNA polymerase_Homo sapiens_hsa030202.08879081
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06004012
16Homologous recombination_Homo sapiens_hsa034402.04699401
17Spliceosome_Homo sapiens_hsa030402.02361486
18Caffeine metabolism_Homo sapiens_hsa002322.01484880
19Base excision repair_Homo sapiens_hsa034101.98268342
20Fanconi anemia pathway_Homo sapiens_hsa034601.96716695
21Cell cycle_Homo sapiens_hsa041101.96594000
22Arachidonic acid metabolism_Homo sapiens_hsa005901.94793590
23One carbon pool by folate_Homo sapiens_hsa006701.92509040
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92408570
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88724375
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88277909
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83578963
28Alzheimers disease_Homo sapiens_hsa050101.82061371
29Fatty acid elongation_Homo sapiens_hsa000621.78544762
30Proteasome_Homo sapiens_hsa030501.69691771
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64750460
32Non-homologous end-joining_Homo sapiens_hsa034501.60973712
33mRNA surveillance pathway_Homo sapiens_hsa030151.58599927
34RNA degradation_Homo sapiens_hsa030181.55066985
35Pyrimidine metabolism_Homo sapiens_hsa002401.52723462
36Thyroid cancer_Homo sapiens_hsa052161.47561803
37Steroid biosynthesis_Homo sapiens_hsa001001.47443617
38Nucleotide excision repair_Homo sapiens_hsa034201.39330042
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30989285
40Linoleic acid metabolism_Homo sapiens_hsa005911.28876728
41Basal transcription factors_Homo sapiens_hsa030221.20833923
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18235682
43p53 signaling pathway_Homo sapiens_hsa041151.14236496
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11305201
45Collecting duct acid secretion_Homo sapiens_hsa049661.10797772
46Folate biosynthesis_Homo sapiens_hsa007901.02965133
47Sulfur relay system_Homo sapiens_hsa041221.01959997
48Pentose phosphate pathway_Homo sapiens_hsa000300.99184160
49Cardiac muscle contraction_Homo sapiens_hsa042600.99017589
50Primary immunodeficiency_Homo sapiens_hsa053400.98554592
51Peroxisome_Homo sapiens_hsa041460.94128004
52Other glycan degradation_Homo sapiens_hsa005110.90657206
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89979745
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89466883
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87389285
56mTOR signaling pathway_Homo sapiens_hsa041500.86890346
57Chemical carcinogenesis_Homo sapiens_hsa052040.86173446
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85105369
59Sulfur metabolism_Homo sapiens_hsa009200.81570497
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80516515
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79571774
62Basal cell carcinoma_Homo sapiens_hsa052170.79146566
63Lysosome_Homo sapiens_hsa041420.78952854
64Herpes simplex infection_Homo sapiens_hsa051680.78876061
65Rheumatoid arthritis_Homo sapiens_hsa053230.78854972
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78296983
67Biosynthesis of amino acids_Homo sapiens_hsa012300.70729266
68Fatty acid metabolism_Homo sapiens_hsa012120.70708030
69Legionellosis_Homo sapiens_hsa051340.69740122
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68180238
71Carbon metabolism_Homo sapiens_hsa012000.67388153
72Osteoclast differentiation_Homo sapiens_hsa043800.66689341
73Selenocompound metabolism_Homo sapiens_hsa004500.65434746
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.65207032
75Propanoate metabolism_Homo sapiens_hsa006400.63439068
76Pathways in cancer_Homo sapiens_hsa052000.58533802
77MicroRNAs in cancer_Homo sapiens_hsa052060.54926911
78Acute myeloid leukemia_Homo sapiens_hsa052210.54722265
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.53737364
80VEGF signaling pathway_Homo sapiens_hsa043700.53570437
81Notch signaling pathway_Homo sapiens_hsa043300.52875102
82Purine metabolism_Homo sapiens_hsa002300.51833550
83Antigen processing and presentation_Homo sapiens_hsa046120.51782454
84Pyruvate metabolism_Homo sapiens_hsa006200.51759234
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.51663054
86Hedgehog signaling pathway_Homo sapiens_hsa043400.51368961
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51310328
88Hippo signaling pathway_Homo sapiens_hsa043900.51299197
89Allograft rejection_Homo sapiens_hsa053300.51260242
90Glutathione metabolism_Homo sapiens_hsa004800.50495549
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48052150
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47148892
93Apoptosis_Homo sapiens_hsa042100.46460854
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.45835695
95HTLV-I infection_Homo sapiens_hsa051660.45777337
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.45385842
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42966481
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42234868
99Non-small cell lung cancer_Homo sapiens_hsa052230.41863646
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41358896
101Salmonella infection_Homo sapiens_hsa051320.39622313
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.37658540
103Viral carcinogenesis_Homo sapiens_hsa052030.36997402
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36912256
105Bladder cancer_Homo sapiens_hsa052190.36861001
106Tryptophan metabolism_Homo sapiens_hsa003800.36519902
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36040277
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34521797
109Epstein-Barr virus infection_Homo sapiens_hsa051690.34028318
110Metabolic pathways_Homo sapiens_hsa011000.33864287
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33632564
112Small cell lung cancer_Homo sapiens_hsa052220.31979815
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31635385
114Tuberculosis_Homo sapiens_hsa051520.31267716
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.30493888
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30273643
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29848034
118Measles_Homo sapiens_hsa051620.29375077
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.28417337
120Autoimmune thyroid disease_Homo sapiens_hsa053200.28292237
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.27948197
122Systemic lupus erythematosus_Homo sapiens_hsa053220.26836771
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26763424
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26501964
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26301498
126Graft-versus-host disease_Homo sapiens_hsa053320.25644461
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25312640
128Regulation of autophagy_Homo sapiens_hsa041400.24610463
129Inositol phosphate metabolism_Homo sapiens_hsa005620.23143175
130TNF signaling pathway_Homo sapiens_hsa046680.22698772
131Ether lipid metabolism_Homo sapiens_hsa005650.22651931
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22476777
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21560939
134Colorectal cancer_Homo sapiens_hsa052100.20989166
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19227693
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.16822522
137Hematopoietic cell lineage_Homo sapiens_hsa046400.15353418
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15083734
139AMPK signaling pathway_Homo sapiens_hsa041520.12036219
140Tight junction_Homo sapiens_hsa045300.11740770
141T cell receptor signaling pathway_Homo sapiens_hsa046600.11730157
142Oocyte meiosis_Homo sapiens_hsa041140.10769038
143Rap1 signaling pathway_Homo sapiens_hsa040150.10692243

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