JCHAIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.95166425
2antigen processing and presentation of endogenous antigen (GO:0019883)8.67218864
3negative regulation of glucose import (GO:0046325)8.52271256
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.31159877
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.31159877
6protein activation cascade (GO:0072376)7.92733407
7negative regulation of B cell proliferation (GO:0030889)7.57713693
8immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00027.18388569
9Fc-gamma receptor signaling pathway (GO:0038094)7.18388569
10Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)7.18388569
11Fc receptor mediated stimulatory signaling pathway (GO:0002431)7.08468283
12positive regulation of respiratory burst (GO:0060267)6.93794886
13regulation of glucose import in response to insulin stimulus (GO:2001273)6.72016716
14negative regulation of glucose transport (GO:0010829)6.71539761
15humoral immune response (GO:0006959)6.40776351
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.09698968
17glomerular filtration (GO:0003094)5.90621140
18retina homeostasis (GO:0001895)5.68635420
19regulation of B cell proliferation (GO:0030888)5.43274320
20gonadal mesoderm development (GO:0007506)5.34740066
21renal filtration (GO:0097205)5.27066058
22B cell receptor signaling pathway (GO:0050853)5.24566622
23ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.21047329
24apoptotic cell clearance (GO:0043277)5.19443791
25regulation of cellular extravasation (GO:0002691)5.08167811
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.96420423
27regulation of respiratory burst (GO:0060263)4.81404216
28angiotensin maturation (GO:0002003)4.73183017
29immune response-activating cell surface receptor signaling pathway (GO:0002429)4.64011916
30immunoglobulin mediated immune response (GO:0016064)4.61137726
31fucose catabolic process (GO:0019317)4.44501016
32L-fucose metabolic process (GO:0042354)4.44501016
33L-fucose catabolic process (GO:0042355)4.44501016
34positive regulation of immunoglobulin production (GO:0002639)4.43148209
35exocrine pancreas development (GO:0031017)4.35880289
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.34937417
37antimicrobial humoral response (GO:0019730)4.29544683
38antibacterial humoral response (GO:0019731)4.26881790
39positive regulation of B cell differentiation (GO:0045579)4.24151368
40intestinal absorption (GO:0050892)4.23412265
41regulation of guanylate cyclase activity (GO:0031282)4.21065303
42positive regulation of Rho protein signal transduction (GO:0035025)4.15613316
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.13068009
44UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08844833
45regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.07105480
46regulation of B cell receptor signaling pathway (GO:0050855)4.05705060
47negative regulation of B cell activation (GO:0050869)4.01940292
48regulation of antigen processing and presentation (GO:0002577)4.00273589
49endoplasmic reticulum unfolded protein response (GO:0030968)3.99972309
50regulation of B cell differentiation (GO:0045577)3.99332134
51transcytosis (GO:0045056)3.97145155
52protein N-linked glycosylation via asparagine (GO:0018279)3.95583603
53peptidyl-asparagine modification (GO:0018196)3.90876967
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.87502925
55cellular response to antibiotic (GO:0071236)3.83145456
56interferon-gamma-mediated signaling pathway (GO:0060333)3.82846011
57cellular response to unfolded protein (GO:0034620)3.82378259
58positive regulation of Rap GTPase activity (GO:0032854)3.79268900
59positive regulation of nuclease activity (GO:0032075)3.77684936
60response to endoplasmic reticulum stress (GO:0034976)3.72749948
61sulfate transmembrane transport (GO:1902358)3.72740639
62positive regulation of antigen processing and presentation (GO:0002579)3.72670452
63regulation of B cell activation (GO:0050864)3.71118620
64regulation of nuclease activity (GO:0032069)3.66839408
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.65357761
66B cell proliferation (GO:0042100)3.64158596
67protein N-linked glycosylation (GO:0006487)3.63668279
68regulation of immunoglobulin production (GO:0002637)3.63464423
69mature B cell differentiation (GO:0002335)3.62545467
70COPI coating of Golgi vesicle (GO:0048205)3.62526089
71Golgi transport vesicle coating (GO:0048200)3.62526089
72cellular response to topologically incorrect protein (GO:0035967)3.56524055
73B cell mediated immunity (GO:0019724)3.52440696
74ER-nucleus signaling pathway (GO:0006984)3.49216358
75antigen processing and presentation via MHC class Ib (GO:0002475)3.48568746
76regulation of MHC class II biosynthetic process (GO:0045346)3.48416632
77respiratory burst (GO:0045730)3.47298309
78regulation of B cell apoptotic process (GO:0002902)3.46881302
79positive thymic T cell selection (GO:0045059)3.46069116
80mature B cell differentiation involved in immune response (GO:0002313)3.43851536
81cellular response to zinc ion (GO:0071294)3.41710287
82production of molecular mediator of immune response (GO:0002440)3.38311587
83negative regulation of cellular response to insulin stimulus (GO:1900077)3.35924679
84immune response-activating signal transduction (GO:0002757)3.32425470
85chaperone mediated protein folding requiring cofactor (GO:0051085)3.28944612
86cellular glucuronidation (GO:0052695)3.28333028
87maintenance of gastrointestinal epithelium (GO:0030277)3.27786079
88labyrinthine layer development (GO:0060711)3.25648485
89regulation of cytokine secretion involved in immune response (GO:0002739)3.22687812
90oligosaccharide biosynthetic process (GO:0009312)3.22570476
91glucuronate metabolic process (GO:0019585)3.20123434
92uronic acid metabolic process (GO:0006063)3.20123434
93phenylpropanoid metabolic process (GO:0009698)3.17421719
94positive regulation of response to oxidative stress (GO:1902884)3.16178567
95positive regulation of cellular response to oxidative stress (GO:1900409)3.16178567
96regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.15518634
97regulation of regulatory T cell differentiation (GO:0045589)3.13802568
98regulation of vitamin metabolic process (GO:0030656)3.13685295
99cellular response to interferon-gamma (GO:0071346)3.12785778
100regulation of Rap GTPase activity (GO:0032317)3.12039420
101NADH metabolic process (GO:0006734)3.11066653
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09980063
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09978986
104intestinal epithelial cell development (GO:0060576)3.09597635
105proline biosynthetic process (GO:0006561)3.09516337
106defense response to Gram-negative bacterium (GO:0050829)3.08248370
107regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.07957487
108endocrine process (GO:0050886)3.07957487
109regulation of systemic arterial blood pressure by hormone (GO:0001990)3.07957487
110cytidine metabolic process (GO:0046087)3.07903139
111cytidine catabolic process (GO:0006216)3.07903139
112cytidine deamination (GO:0009972)3.07903139
113detection of bacterium (GO:0016045)3.07659401
114positive regulation of guanylate cyclase activity (GO:0031284)3.06967833
115nerve growth factor signaling pathway (GO:0038180)3.05827870
116positive regulation of gamma-delta T cell activation (GO:0046645)3.05475101
117maternal placenta development (GO:0001893)3.03608544
118activation of immune response (GO:0002253)3.01949240
119sulfate transport (GO:0008272)3.01871359
120glycosphingolipid catabolic process (GO:0046479)2.98026296
121response to type I interferon (GO:0034340)2.97656164
122type I interferon signaling pathway (GO:0060337)2.94858875
123cellular response to type I interferon (GO:0071357)2.94858875
124immune response-regulating cell surface receptor signaling pathway (GO:0002768)2.93696738
125receptor guanylyl cyclase signaling pathway (GO:0007168)2.93474561
126O-glycan processing (GO:0016266)2.92951207
127Fc-epsilon receptor signaling pathway (GO:0038095)2.92580239
128interleukin-6-mediated signaling pathway (GO:0070102)2.91615176
129detection of other organism (GO:0098543)2.90390895
130response to unfolded protein (GO:0006986)2.87232774
131regulation of interferon-beta biosynthetic process (GO:0045357)2.86339528
132T cell costimulation (GO:0031295)2.86242022
133negative thymic T cell selection (GO:0045060)2.85901434
134positive regulation of production of molecular mediator of immune response (GO:0002702)2.84580110
135regulation of interleukin-12 biosynthetic process (GO:0045075)2.84095705
136glycolipid catabolic process (GO:0019377)2.82392561
137positive regulation of pseudopodium assembly (GO:0031274)2.82384294
138lymphocyte costimulation (GO:0031294)2.81811856
139antigen receptor-mediated signaling pathway (GO:0050851)2.81746051
140COPII vesicle coating (GO:0048208)2.81317948
141Fc receptor signaling pathway (GO:0038093)2.80523656
142natural killer cell mediated cytotoxicity (GO:0042267)2.79862043
143natural killer cell mediated immunity (GO:0002228)2.79862043
144response to interferon-gamma (GO:0034341)2.79088355
145calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.77495658
146peptide catabolic process (GO:0043171)2.76346974
147regulation of cGMP biosynthetic process (GO:0030826)2.74222108
148regulation of interferon-alpha production (GO:0032647)2.74175152
149cell redox homeostasis (GO:0045454)2.74037104
150establishment of endothelial barrier (GO:0061028)2.73359385
151tongue development (GO:0043586)2.72462946
152ethanol oxidation (GO:0006069)2.72021487
153regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.71841954
154response to topologically incorrect protein (GO:0035966)2.69983241
155adhesion of symbiont to host cell (GO:0044650)2.67923026
156virion attachment to host cell (GO:0019062)2.67923026
157negative regulation of cell killing (GO:0031342)2.67224754
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67224754
159renal system process involved in regulation of blood volume (GO:0001977)2.66247941
160dendritic cell chemotaxis (GO:0002407)2.66138557
161regulation of systemic arterial blood pressure (GO:0003073)2.64893036
162ceramide catabolic process (GO:0046514)2.63884280
163bile acid and bile salt transport (GO:0015721)2.62871578
164thrombin receptor signaling pathway (GO:0070493)2.62084141
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.59772954
166cellular response to reactive nitrogen species (GO:1902170)2.59391328
167eosinophil chemotaxis (GO:0048245)2.59348108
168positive T cell selection (GO:0043368)2.59163334
169NIK/NF-kappaB signaling (GO:0038061)2.56899031
170GDP-mannose metabolic process (GO:0019673)2.56838626
171defense response to protozoan (GO:0042832)2.53240253
172regulation of T cell mediated cytotoxicity (GO:0001914)2.51999237
173bicarbonate transport (GO:0015701)2.49179211
174positive regulation of Cdc42 GTPase activity (GO:0043089)2.48328086
175regulation of pseudopodium assembly (GO:0031272)2.46822734
176positive regulation of type 2 immune response (GO:0002830)2.45290400
177response to nitric oxide (GO:0071731)2.44901479
178positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44603983
179complement activation, classical pathway (GO:0006958)15.9131498
180complement activation (GO:0006956)12.1951840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.67230512
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.79506366
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.13177844
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.60624833
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.26829910
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.12100571
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00494660
8MYC_22102868_ChIP-Seq_BL_Human3.67561862
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.39288577
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.38091797
11CDX2_20551321_ChIP-Seq_CACO-2_Human3.34476616
12RUNX_20019798_ChIP-Seq_JUKART_Human2.98378232
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.92634942
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91381035
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.70024633
16MYB_26560356_Chip-Seq_TH2_Human2.59123157
17MAF_26560356_Chip-Seq_TH1_Human2.57478513
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51626651
19VDR_21846776_ChIP-Seq_THP-1_Human2.49635712
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48809741
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.36383369
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33761119
23MYB_26560356_Chip-Seq_TH1_Human2.32129727
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29581808
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26887225
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26619729
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24802513
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21441693
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09994961
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09757281
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99062807
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95686489
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.93135641
34GATA4_25053715_ChIP-Seq_YYC3_Human1.89847463
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84499050
36GATA1_22025678_ChIP-Seq_K562_Human1.84131394
37SCL_19346495_ChIP-Seq_HPC-7_Human1.81657766
38UTX_26944678_Chip-Seq_JUKART_Human1.79461469
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75583633
40VDR_24763502_ChIP-Seq_THP-1_Human1.74269500
41SPI1_23547873_ChIP-Seq_NB4_Human1.73459183
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69507180
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.67141710
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66250463
45GATA3_27048872_Chip-Seq_THYMUS_Human1.65377547
46GATA6_25053715_ChIP-Seq_YYC3_Human1.63556860
47PU.1_20513432_ChIP-Seq_Bcells_Mouse1.62893018
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.62578855
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58821435
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56664256
51SOX2_20726797_ChIP-Seq_SW620_Human1.55729576
52TCF7_22412390_ChIP-Seq_EML_Mouse1.51561500
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51341251
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50766027
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.47674504
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46782481
57GATA3_26560356_Chip-Seq_TH2_Human1.45219381
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43355988
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42823884
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42620692
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40052498
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36097667
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33791965
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32146808
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31120400
66MAF_26560356_Chip-Seq_TH2_Human1.29626549
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26113680
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24112090
69SPI1_23127762_ChIP-Seq_K562_Human1.22476317
70E2F7_22180533_ChIP-Seq_HELA_Human1.17322106
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14131782
72CEBPB_22108803_ChIP-Seq_LS180_Human1.13045067
73KDM2B_26808549_Chip-Seq_DND41_Human1.12845062
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12524406
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12171808
76VDR_24787735_ChIP-Seq_THP-1_Human1.11401835
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11042392
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10889285
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09594819
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.08888418
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08602746
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06765895
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.06313498
84LXR_22292898_ChIP-Seq_THP-1_Human1.04748189
85PU_27001747_Chip-Seq_BMDM_Mouse1.03565066
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02971339
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02633995
88CLOCK_20551151_ChIP-Seq_293T_Human1.01013135
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99574289
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.99555312
91CIITA_25753668_ChIP-Seq_RAJI_Human0.98044648
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97480341
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96742176
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96710567
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96113764
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96073668
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95696008
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95322115
99KDM5A_27292631_Chip-Seq_BREAST_Human0.95106334
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.95040737
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94971530
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94846220
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94733785
104CDX2_22108803_ChIP-Seq_LS180_Human0.93939830
105GATA2_19941826_ChIP-Seq_K562_Human0.93134843
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92787264
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92030443
108RXR_22108803_ChIP-Seq_LS180_Human0.90442261
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90174033
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89923963
111BCL6_27268052_Chip-Seq_Bcells_Human0.89033243
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88945082
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88632569
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87670151
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87087789
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.86640665
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86491484
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85893907
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85529221
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.85401154
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83629262
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.83536032
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82993475
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.82283789
125STAT1_20625510_ChIP-Seq_HELA_Human0.82258615
126P300_27268052_Chip-Seq_Bcells_Human0.81596101
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.81093771
128CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81008697
129LXR_22158963_ChIP-Seq_LIVER_Mouse0.79866696
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79510437
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79234468
132SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78070928
133EGR1_19032775_ChIP-ChIP_M12_Human0.77685716
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.76688720
135GATA1_19941826_ChIP-Seq_K562_Human0.75889901
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75777279
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75735074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.86639123
2MP0003303_peritoneal_inflammation4.81907343
3MP0001800_abnormal_humoral_immune4.24259184
4MP0001790_abnormal_immune_system3.93448320
5MP0005387_immune_system_phenotype3.93448320
6MP0005671_abnormal_response_to3.78427424
7MP0002138_abnormal_hepatobiliary_system3.56378045
8MP0004264_abnormal_extraembryonic_tissu3.51224120
9MP0003300_gastrointestinal_ulcer3.45925438
10MP0010234_abnormal_vibrissa_follicle3.44823232
11MP0002139_abnormal_hepatobiliary_system3.25658794
12MP0002452_abnormal_antigen_presenting3.22875769
13MP0002723_abnormal_immune_serum2.76080694
14MP0005000_abnormal_immune_tolerance2.69473918
15MP0002420_abnormal_adaptive_immunity2.63179709
16MP0001819_abnormal_immune_cell2.59257311
17MP0001879_abnormal_lymphatic_vessel2.57232316
18MP0005025_abnormal_response_to2.47717606
19MP0001873_stomach_inflammation2.41019840
20MP0005085_abnormal_gallbladder_physiolo2.35232780
21MP0002398_abnormal_bone_marrow2.33724265
22MP0000716_abnormal_immune_system2.29323711
23MP0010155_abnormal_intestine_physiology2.27125923
24MP0004782_abnormal_surfactant_physiolog2.25870414
25MP0000685_abnormal_immune_system2.25706913
26MP0002148_abnormal_hypersensitivity_rea2.22191432
27MP0002166_altered_tumor_susceptibility2.17884364
28MP0000689_abnormal_spleen_morphology2.08721348
29MP0003763_abnormal_thymus_physiology2.07275772
30MP0009785_altered_susceptibility_to2.00628290
31MP0003436_decreased_susceptibility_to1.94486407
32MP0005310_abnormal_salivary_gland1.93763159
33MP0004043_abnormal_pH_regulation1.89523365
34MP0002429_abnormal_blood_cell1.89315201
35MP0001845_abnormal_inflammatory_respons1.87562709
36MP0002419_abnormal_innate_immunity1.84020904
37MP0006054_spinal_hemorrhage1.83856837
38MP0001853_heart_inflammation1.78664971
39MP0003866_abnormal_defecation1.75052917
40MP0002722_abnormal_immune_system1.74015573
41MP0005166_decreased_susceptibility_to1.70585732
42MP0001664_abnormal_digestion1.69482484
43MP0005365_abnormal_bile_salt1.69351849
44MP0000490_abnormal_crypts_of1.66857014
45MP0002933_joint_inflammation1.66507212
46MP0004947_skin_inflammation1.64820201
47MP0009333_abnormal_splenocyte_physiolog1.63453055
48MP0002006_tumorigenesis1.61615775
49MP0003868_abnormal_feces_composition1.53010370
50MP0001663_abnormal_digestive_system1.52768755
51MP0003252_abnormal_bile_duct1.45326860
52MP0002009_preneoplasia1.44351104
53MP0002405_respiratory_system_inflammati1.42628622
54MP0009379_abnormal_foot_pigmentation1.41674798
55MP0001765_abnormal_ion_homeostasis1.39960430
56MP0006082_CNS_inflammation1.39855891
57MP0004147_increased_porphyrin_level1.39175037
58MP0000465_gastrointestinal_hemorrhage1.23982866
59MP0000703_abnormal_thymus_morphology1.12540790
60MP0009840_abnormal_foam_cell1.09921801
61MP0005464_abnormal_platelet_physiology1.09451425
62MP0005381_digestive/alimentary_phenotyp1.07618421
63MP0002876_abnormal_thyroid_physiology1.07238944
64MP0003195_calcinosis1.05709475
65MP0008004_abnormal_stomach_pH1.04077616
66MP0003693_abnormal_embryo_hatching1.01957368
67MP0004510_myositis1.00859925
68MP0001533_abnormal_skeleton_physiology1.00759990
69MP0001666_abnormal_nutrient_absorption1.00355787
70MP0002136_abnormal_kidney_physiology0.99103439
71MP0003191_abnormal_cellular_cholesterol0.96623846
72MP0000477_abnormal_intestine_morphology0.96483415
73MP0001919_abnormal_reproductive_system0.95839263
74MP0008469_abnormal_protein_level0.94328762
75MP0002693_abnormal_pancreas_physiology0.93428841
76MP0003806_abnormal_nucleotide_metabolis0.92144340
77MP0001191_abnormal_skin_condition0.90427254
78MP0002019_abnormal_tumor_incidence0.90369025
79MP0004019_abnormal_vitamin_homeostasis0.90351070
80MP0000003_abnormal_adipose_tissue0.88900257
81MP0005360_urolithiasis0.85505282
82MP0001764_abnormal_homeostasis0.85058348
83MP0003075_altered_response_to0.84544350
84MP0005332_abnormal_amino_acid0.83108949
85MP0005397_hematopoietic_system_phenotyp0.81535640
86MP0001545_abnormal_hematopoietic_system0.81535640
87MP0005584_abnormal_enzyme/coenzyme_acti0.80977636
88MP0003724_increased_susceptibility_to0.78246434
89MP0003045_fibrosis0.78129228
90MP0000609_abnormal_liver_physiology0.77376620
91MP0005076_abnormal_cell_differentiation0.76307276
92MP0005319_abnormal_enzyme/_coenzyme0.74597955
93MP0001756_abnormal_urination0.74561775
94MP0005023_abnormal_wound_healing0.74553027
95MP0003656_abnormal_erythrocyte_physiolo0.74457284
96MP0010352_gastrointestinal_tract_polyps0.74165222
97MP0004858_abnormal_nervous_system0.73970237
98MP0002396_abnormal_hematopoietic_system0.72984317
99MP0000613_abnormal_salivary_gland0.72534644
100MP0003943_abnormal_hepatobiliary_system0.72503053
101MP0000678_abnormal_parathyroid_gland0.69676845
102MP0000470_abnormal_stomach_morphology0.69162951
103MP0003183_abnormal_peptide_metabolism0.69126760
104MP0005451_abnormal_body_composition0.68455331
105MP0005058_abnormal_lysosome_morphology0.67740008
106MP0009643_abnormal_urine_homeostasis0.67594623
107MP0002796_impaired_skin_barrier0.67479374
108MP0005165_increased_susceptibility_to0.66827482
109MP0000604_amyloidosis0.66253952
110MP0002168_other_aberrant_phenotype0.65240163
111MP0009764_decreased_sensitivity_to0.64637839
112MP0001944_abnormal_pancreas_morphology0.63911842
113MP0004808_abnormal_hematopoietic_stem0.63870255
114MP0000858_altered_metastatic_potential0.61841445
115MP0010329_abnormal_lipoprotein_level0.61180293
116MP0010307_abnormal_tumor_latency0.60759951
117MP0000013_abnormal_adipose_tissue0.60320951
118MP0008872_abnormal_physiological_respon0.59447030
119MP0002998_abnormal_bone_remodeling0.57971085
120MP0005388_respiratory_system_phenotype0.57148934
121MP0002133_abnormal_respiratory_system0.57148934
122MP0003795_abnormal_bone_structure0.54249903
123MP0009931_abnormal_skin_appearance0.51319586
124MP0002083_premature_death0.49049480
125MP0001881_abnormal_mammary_gland0.48721736
126MP0005636_abnormal_mineral_homeostasis0.47849360
127MP0003566_abnormal_cell_adhesion0.47717342
128MP0001542_abnormal_bone_strength0.46870859
129MP0003828_pulmonary_edema0.46340455
130MP0009763_increased_sensitivity_to0.46241946
131MP0000249_abnormal_blood_vessel0.45760239
132MP0003448_altered_tumor_morphology0.45120318
133MP0000681_abnormal_thyroid_gland0.45046587
134MP0009765_abnormal_xenobiotic_induced0.43403643

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.03619279
2B lymphocytopenia (HP:0010976)8.46959273
3Abnormality of B cell number (HP:0010975)8.46959273
4Colitis (HP:0002583)7.30014211
5Recurrent sinusitis (HP:0011108)6.65169948
6Recurrent bronchitis (HP:0002837)6.55923589
7Hyperactive renin-angiotensin system (HP:0000841)6.42584478
8Cellulitis (HP:0100658)6.06031236
9Inflammation of the large intestine (HP:0002037)5.67649626
10Papilloma (HP:0012740)5.40025564
11Verrucae (HP:0200043)5.40025564
12Gastrointestinal inflammation (HP:0004386)5.35899494
13Decreased circulating renin level (HP:0003351)5.32611584
14Recurrent viral infections (HP:0004429)5.28267557
15IgM deficiency (HP:0002850)5.26067276
16Meningitis (HP:0001287)5.07311609
17Gastrointestinal stroma tumor (HP:0100723)5.07212143
18Recurrent pneumonia (HP:0006532)4.95845214
19Chronic otitis media (HP:0000389)4.64748937
20Metabolic alkalosis (HP:0200114)4.47882916
21Abnormality of renin-angiotensin system (HP:0000847)4.40464077
22Chronic sinusitis (HP:0011109)4.29221196
23Onycholysis (HP:0001806)4.17607037
24Recurrent lower respiratory tract infections (HP:0002783)4.09257183
25Interstitial pulmonary disease (HP:0006530)4.00358539
26Systemic lupus erythematosus (HP:0002725)3.97038044
27Myositis (HP:0100614)3.96981695
28Chronic diarrhea (HP:0002028)3.94714223
29Osteomyelitis (HP:0002754)3.93034344
30Bronchitis (HP:0012387)3.92079251
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91946856
32Malnutrition (HP:0004395)3.79628920
33Elevated erythrocyte sedimentation rate (HP:0003565)3.77090272
34Alkalosis (HP:0001948)3.68805356
35Flat acetabular roof (HP:0003180)3.65171693
36Skin rash (HP:0000988)3.63192603
37Recurrent otitis media (HP:0000403)3.47271230
38Abnormality of chloride homeostasis (HP:0011422)3.45100128
39Emphysema (HP:0002097)3.43961910
40Vasculitis (HP:0002633)3.32083670
41Abnormality of small intestinal villus morphology (HP:0011472)3.27128093
42Villous atrophy (HP:0011473)3.27128093
43Hyperaldosteronism (HP:0000859)3.23143132
44IgA deficiency (HP:0002720)3.22816678
45Abnormality of T cell physiology (HP:0011840)3.18108257
46Optic neuritis (HP:0100653)3.15755348
47Retrobulbar optic neuritis (HP:0100654)3.15755348
48Sepsis (HP:0100806)3.13896082
49Dry hair (HP:0011359)3.01011385
50Nasal polyposis (HP:0100582)2.97444811
51Erythema (HP:0010783)2.92063865
52Restrictive lung disease (HP:0002091)2.89206010
53Pulmonary infiltrates (HP:0002113)2.88250171
54Basal cell carcinoma (HP:0002671)2.84630637
55Ileus (HP:0002595)2.84248455
56Conical tooth (HP:0000698)2.81091617
57Orchitis (HP:0100796)2.79041815
58Spontaneous hematomas (HP:0007420)2.75572889
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73251100
60Recurrent abscess formation (HP:0002722)2.73119751
61IgG deficiency (HP:0004315)2.72233632
62Eczematoid dermatitis (HP:0000976)2.70661474
63Urticaria (HP:0001025)2.65434745
64Abnormality of the nasal mucosa (HP:0000433)2.64325516
65Bronchiectasis (HP:0002110)2.63804392
66Lymphopenia (HP:0001888)2.63141375
67Abnormality of the prostate (HP:0008775)2.54977597
68Autoimmune hemolytic anemia (HP:0001890)2.54020926
69Abdominal distention (HP:0003270)2.53230536
70Abnormality of T cells (HP:0002843)2.52373428
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.50900407
72Thyroiditis (HP:0100646)2.50435438
73Recurrent fungal infections (HP:0002841)2.42661809
74Nephritis (HP:0000123)2.40715983
75Abnormality of proline metabolism (HP:0010907)2.39862494
76Hydroxyprolinuria (HP:0003080)2.39862494
77Keratoconjunctivitis sicca (HP:0001097)2.39536052
78Abnormality of complement system (HP:0005339)2.37665662
79Abnormality of the vitamin B12 metabolism (HP:0004341)2.37315191
80Premature loss of primary teeth (HP:0006323)2.35233531
81Pustule (HP:0200039)2.35050101
82Prostate neoplasm (HP:0100787)2.34534045
83Obstructive lung disease (HP:0006536)2.34389554
84Chronic obstructive pulmonary disease (HP:0006510)2.34389554
85Recurrent bacterial skin infections (HP:0005406)2.32903347
86Glomerulonephritis (HP:0000099)2.32119283
87Vacuolated lymphocytes (HP:0001922)2.31325775
88Abnormal delayed hypersensitivity skin test (HP:0002963)2.30666342
89Hyponatremia (HP:0002902)2.29950622
90Skin ulcer (HP:0200042)2.29915975
91Squamous cell carcinoma (HP:0002860)2.29663271
92Panhypogammaglobulinemia (HP:0003139)2.29543841
93Hypokalemia (HP:0002900)2.29370744
94Thrombocytosis (HP:0001894)2.28551926
95Fat malabsorption (HP:0002630)2.28321942
96Ridged nail (HP:0001807)2.27233884
97Abnormal tarsal ossification (HP:0008369)2.26949020
98Hyperkalemia (HP:0002153)2.23626733
99Keratoconjunctivitis (HP:0001096)2.21303651
100Complement deficiency (HP:0004431)2.21209242
101Neutropenia (HP:0001875)2.20437310
102Autoimmune thrombocytopenia (HP:0001973)2.17512869
103Right ventricular cardiomyopathy (HP:0011663)2.17166263
104Amelogenesis imperfecta (HP:0000705)2.15526266
105Gastrointestinal infarctions (HP:0005244)2.14674373
106Abnormality of vitamin B metabolism (HP:0004340)2.14075371
107Segmental peripheral demyelination/remyelination (HP:0003481)2.12805021
108Hemorrhage of the eye (HP:0011885)2.11761865
109Abnormality of incisor morphology (HP:0011063)2.11705705
110Flattened epiphyses (HP:0003071)2.11480620
111Abnormality of macrophages (HP:0004311)2.10631338
112Conjugated hyperbilirubinemia (HP:0002908)2.10486872
113Increased IgE level (HP:0003212)2.09778309
114Abnormality of potassium homeostasis (HP:0011042)2.07736885
115Flat capital femoral epiphysis (HP:0003370)2.07292357
116Recurrent gram-negative bacterial infections (HP:0005420)2.04292495
117Dehydration (HP:0001944)2.02537289
118Mediastinal lymphadenopathy (HP:0100721)1.99882175
119Congenital, generalized hypertrichosis (HP:0004540)1.96154554
120Hypergammaglobulinemia (HP:0010702)1.95416282
121Recurrent skin infections (HP:0001581)1.94356159
122Adrenal overactivity (HP:0002717)1.93909678
123Neonatal short-limb short stature (HP:0008921)1.93903867
124Hemoptysis (HP:0002105)1.93458960
125Encephalitis (HP:0002383)1.93366172
126Gingivitis (HP:0000230)1.93294791
127Arterial thrombosis (HP:0004420)1.93009552
128Pulmonary embolism (HP:0002204)1.90141657
129Abnormality of T cell number (HP:0011839)1.89966442
130Petechiae (HP:0000967)1.86577239
131Teleangiectasia of the skin (HP:0100585)1.86246123
132Arthralgia (HP:0002829)1.85515534
133T lymphocytopenia (HP:0005403)1.83128044
134Myocardial infarction (HP:0001658)1.79778701
135Leukopenia (HP:0001882)1.77967067
136Vascular calcification (HP:0004934)1.74370958
137Blepharitis (HP:0000498)1.72715374
138Gangrene (HP:0100758)1.67831050
139Mitral stenosis (HP:0001718)1.61741470
140Recurrent cutaneous fungal infections (HP:0011370)1.61390862
141Chronic mucocutaneous candidiasis (HP:0002728)1.61390862
142Lymphoma (HP:0002665)1.61271160
143Microcytic anemia (HP:0001935)1.60865737
144Fatigue (HP:0012378)1.57324206
145Cardiovascular calcification (HP:0011915)1.56547734
146Viral hepatitis (HP:0006562)1.56173190
147Chest pain (HP:0100749)1.53928902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.69983117
2ACVR1B4.65408453
3MAP4K14.56056883
4NME24.31532676
5TBK13.00499007
6MAP3K142.93471450
7MST1R2.87176675
8TYK22.82045973
9TXK2.80799514
10MAP3K132.70076348
11GRK62.55462540
12IKBKE2.42590281
13TAOK32.39174171
14IRAK32.34349378
15CSF1R2.27988656
16SYK2.27848868
17PIK3CA2.25094895
18STK392.18412115
19BMPR1B2.07232543
20MET2.04348423
21KIT1.96558957
22IRAK41.92391518
23RIPK41.86119876
24EPHA21.84293766
25OXSR11.78120154
26STK241.72132649
27JAK31.57631154
28FRK1.51357233
29EIF2AK31.45362511
30RIPK11.45224120
31BTK1.43997293
32JAK11.43394977
33BLK1.39857973
34IKBKB1.38628660
35MAP3K91.35840752
36LMTK21.35203254
37LYN1.29708843
38BCKDK1.28998875
39ITK1.28018956
40ARAF1.21984118
41TGFBR11.19796849
42BMPR21.18339532
43MAP3K101.17356148
44TEC1.13491594
45TGFBR21.13287270
46MST41.10024444
47MATK1.06475063
48HCK1.05669119
49PKN21.05412693
50SMG11.03174930
51PRKCH1.00686316
52SCYL20.99654756
53EPHA30.99283705
54LCK0.99172668
55HIPK20.94686494
56PIK3CG0.92784822
57MAP3K10.92565534
58CDK80.92355135
59KSR20.91288265
60FGFR30.91215343
61FGFR40.90965972
62NEK90.90801620
63STK100.90711970
64LRRK20.85875969
65ZAP700.83853931
66CSK0.83110282
67PRKCQ0.80465342
68TLK10.79962387
69CHUK0.78913282
70FES0.77919875
71EPHB10.76982326
72CDC42BPA0.76694725
73PRKG20.76201544
74SIK20.75515172
75EEF2K0.69871699
76PIM10.69027248
77WNK40.68739537
78PDPK10.66575476
79GRK10.65847708
80CAMKK20.60452003
81JAK20.59165610
82RAF10.57496610
83MAP2K30.57118921
84MAP3K20.56597597
85FLT30.55639159
86MAPK120.54298360
87PDK10.54109712
88MAP3K120.53843853
89RPS6KB20.53476907
90CDK190.51138722
91MAP2K20.49560826
92PRPF4B0.49136617
93FER0.48017978
94STK160.47250994
95CDK60.45702541
96FYN0.45370078
97NEK20.45100945
98PRKCI0.44064516
99RPS6KA40.42300138
100SIK10.42220202
101MAPK110.41956829
102PRKAA20.40589615
103MYLK0.40406138
104CLK10.37733113
105CAMKK10.37570117
106MAP3K70.35937993
107DDR20.35001262
108CDK90.34996844
109ABL10.34701529
110IRAK20.33689594
111TTN0.33484727
112PRKCD0.32031676
113EIF2AK10.31551953
114YES10.31412707
115MAPKAPK50.30215761
116TESK20.28569338
117RET0.28264808
118PDK20.27807666
119MOS0.27420423
120INSR0.25730886
121MAPK40.25214891
122NLK0.24932420
123MAPK70.24303941
124MAP3K80.23211566
125TNIK0.23063816
126ALK0.22661326
127EGFR0.21733110
128MAPKAPK20.20974278
129PRKD10.20511176
130IRAK10.20369143
131PTK60.18904583
132SIK30.17720682
133IGF1R0.16639964
134PRKD20.15022699
135MAP2K60.14514497
136CCNB10.14287056
137MAPK30.12852961
138MAPKAPK30.11901764

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046727.49880442
2Protein export_Homo sapiens_hsa030605.57590995
3Primary immunodeficiency_Homo sapiens_hsa053404.70009499
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.70536550
5B cell receptor signaling pathway_Homo sapiens_hsa046623.41202884
6Type I diabetes mellitus_Homo sapiens_hsa049403.07048888
7Cyanoamino acid metabolism_Homo sapiens_hsa004603.06829026
8N-Glycan biosynthesis_Homo sapiens_hsa005102.88633071
9Asthma_Homo sapiens_hsa053102.86762008
10Sulfur metabolism_Homo sapiens_hsa009202.35938348
11Autoimmune thyroid disease_Homo sapiens_hsa053202.21079377
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20899040
13Antigen processing and presentation_Homo sapiens_hsa046122.17824635
14Nitrogen metabolism_Homo sapiens_hsa009102.12952000
15Leishmaniasis_Homo sapiens_hsa051402.09692742
16Allograft rejection_Homo sapiens_hsa053302.00325820
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.83420538
18Mineral absorption_Homo sapiens_hsa049781.58823187
19T cell receptor signaling pathway_Homo sapiens_hsa046601.55348585
20Hematopoietic cell lineage_Homo sapiens_hsa046401.51262862
21Osteoclast differentiation_Homo sapiens_hsa043801.49363051
22Other glycan degradation_Homo sapiens_hsa005111.39636123
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34945487
24Malaria_Homo sapiens_hsa051441.34818190
25Arginine biosynthesis_Homo sapiens_hsa002201.33002313
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32860004
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31553819
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29519339
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19647869
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.19436722
31Folate biosynthesis_Homo sapiens_hsa007901.13620225
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13009739
33Staphylococcus aureus infection_Homo sapiens_hsa051501.12761539
34Measles_Homo sapiens_hsa051621.11004474
35Systemic lupus erythematosus_Homo sapiens_hsa053221.09821086
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.09194249
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06001227
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02182559
39Pertussis_Homo sapiens_hsa051331.01934246
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99825077
41Toxoplasmosis_Homo sapiens_hsa051450.98671190
42Tuberculosis_Homo sapiens_hsa051520.97030922
43African trypanosomiasis_Homo sapiens_hsa051430.96490988
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95948874
45Vitamin digestion and absorption_Homo sapiens_hsa049770.93392834
46Linoleic acid metabolism_Homo sapiens_hsa005910.93195268
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92626168
48Fructose and mannose metabolism_Homo sapiens_hsa000510.91037055
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.89098442
50Arachidonic acid metabolism_Homo sapiens_hsa005900.86985995
51Legionellosis_Homo sapiens_hsa051340.86004431
52Vibrio cholerae infection_Homo sapiens_hsa051100.81406336
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80973120
54Chemokine signaling pathway_Homo sapiens_hsa040620.78853834
55Hepatitis B_Homo sapiens_hsa051610.78067390
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77312200
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75795394
58Phagosome_Homo sapiens_hsa041450.75779071
59Thyroid hormone synthesis_Homo sapiens_hsa049180.74913536
60Fatty acid degradation_Homo sapiens_hsa000710.74559607
61Herpes simplex infection_Homo sapiens_hsa051680.73120408
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73112483
63Retinol metabolism_Homo sapiens_hsa008300.72862397
64Viral myocarditis_Homo sapiens_hsa054160.72379248
65Ether lipid metabolism_Homo sapiens_hsa005650.67502702
66Influenza A_Homo sapiens_hsa051640.66870945
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.66333467
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66210131
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64759952
70Apoptosis_Homo sapiens_hsa042100.64403336
71PPAR signaling pathway_Homo sapiens_hsa033200.63906379
72Caffeine metabolism_Homo sapiens_hsa002320.63171671
73Bile secretion_Homo sapiens_hsa049760.61967146
74Base excision repair_Homo sapiens_hsa034100.60408167
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58467496
76Chemical carcinogenesis_Homo sapiens_hsa052040.58230461
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56522023
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56291959
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56001194
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.53124273
81TNF signaling pathway_Homo sapiens_hsa046680.52263423
82Hepatitis C_Homo sapiens_hsa051600.50448175
83Platelet activation_Homo sapiens_hsa046110.47837812
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47761442
85Arginine and proline metabolism_Homo sapiens_hsa003300.47063969
86HTLV-I infection_Homo sapiens_hsa051660.47034772
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45777715
88Acute myeloid leukemia_Homo sapiens_hsa052210.42985552
89Non-homologous end-joining_Homo sapiens_hsa034500.41695648
90Shigellosis_Homo sapiens_hsa051310.40660870
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40590539
92Tryptophan metabolism_Homo sapiens_hsa003800.39187037
93Histidine metabolism_Homo sapiens_hsa003400.38556408
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37360323
95Glycerolipid metabolism_Homo sapiens_hsa005610.35754710
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35460966
97VEGF signaling pathway_Homo sapiens_hsa043700.35320865
98Long-term potentiation_Homo sapiens_hsa047200.34625993
99Epstein-Barr virus infection_Homo sapiens_hsa051690.33710721
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31789714
101Pancreatic cancer_Homo sapiens_hsa052120.30217857
102Sphingolipid metabolism_Homo sapiens_hsa006000.28360956
103Non-small cell lung cancer_Homo sapiens_hsa052230.27844668
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27559471
105Lysosome_Homo sapiens_hsa041420.27556464
106Renin-angiotensin system_Homo sapiens_hsa046140.26596842
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25572954
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25239770
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25178687
110Chronic myeloid leukemia_Homo sapiens_hsa052200.20920878
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.20290547
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19592134
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19318082
114Small cell lung cancer_Homo sapiens_hsa052220.18568924
115Viral carcinogenesis_Homo sapiens_hsa052030.18548586
116Fat digestion and absorption_Homo sapiens_hsa049750.16337106
117Renin secretion_Homo sapiens_hsa049240.15707182
118Pancreatic secretion_Homo sapiens_hsa049720.14618535
119Rheumatoid arthritis_Homo sapiens_hsa053230.14530946
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.14456797
121DNA replication_Homo sapiens_hsa030300.14377824
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14086566
123Protein digestion and absorption_Homo sapiens_hsa049740.13634286
124Insulin resistance_Homo sapiens_hsa049310.13307471
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12491725
126Ribosome_Homo sapiens_hsa030100.11798543
127Prostate cancer_Homo sapiens_hsa052150.09631608
128Proteoglycans in cancer_Homo sapiens_hsa052050.08973001
129Graft-versus-host disease_Homo sapiens_hsa053320.08331723
130Pentose phosphate pathway_Homo sapiens_hsa000300.08272716
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08125379
132ABC transporters_Homo sapiens_hsa020100.07884768
133Starch and sucrose metabolism_Homo sapiens_hsa005000.07671191
134Galactose metabolism_Homo sapiens_hsa000520.07291654
135Sulfur relay system_Homo sapiens_hsa041220.06817835

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