JAKMIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.70406300
2central nervous system myelination (GO:0022010)5.70406300
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79844762
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74026130
5synaptic vesicle maturation (GO:0016188)4.70186529
6sodium ion export (GO:0071436)4.68698338
7neuronal action potential propagation (GO:0019227)4.58491852
8synaptic vesicle exocytosis (GO:0016079)4.56702926
9neuron cell-cell adhesion (GO:0007158)4.52919571
10positive regulation of synapse maturation (GO:0090129)4.52197334
11locomotory exploration behavior (GO:0035641)4.45025557
12glutamate secretion (GO:0014047)4.36260844
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35154616
14vocalization behavior (GO:0071625)4.25146244
15regulation of synaptic vesicle exocytosis (GO:2000300)4.17609820
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.17006977
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14155341
18protein localization to synapse (GO:0035418)4.00153527
19presynaptic membrane organization (GO:0097090)3.97663108
20presynaptic membrane assembly (GO:0097105)3.93668191
21potassium ion homeostasis (GO:0055075)3.86320940
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84179548
23glutamate receptor signaling pathway (GO:0007215)3.83913840
24L-amino acid import (GO:0043092)3.81719612
25transmission of nerve impulse (GO:0019226)3.79776781
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79535387
27regulation of glutamate receptor signaling pathway (GO:1900449)3.76447090
28regulation of neuronal synaptic plasticity (GO:0048168)3.75482606
29negative regulation of neurotransmitter transport (GO:0051589)3.74089988
30synaptic transmission, glutamatergic (GO:0035249)3.73514218
31neuron-neuron synaptic transmission (GO:0007270)3.69940117
32long-chain fatty acid biosynthetic process (GO:0042759)3.63433116
33dendritic spine morphogenesis (GO:0060997)3.61676593
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60900237
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.60884073
36regulation of synaptic vesicle transport (GO:1902803)3.59436741
37regulation of synapse maturation (GO:0090128)3.56859803
38adult walking behavior (GO:0007628)3.56257849
39neurotransmitter secretion (GO:0007269)3.56051999
40myelination (GO:0042552)3.55646612
41potassium ion import (GO:0010107)3.55547801
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.55031559
43membrane depolarization during action potential (GO:0086010)3.54968501
44gamma-aminobutyric acid transport (GO:0015812)3.52770103
45axon ensheathment (GO:0008366)3.51643906
46ensheathment of neurons (GO:0007272)3.51643906
47positive regulation of dendritic spine development (GO:0060999)3.49565692
48detection of calcium ion (GO:0005513)3.49121165
49neurotransmitter-gated ion channel clustering (GO:0072578)3.47453378
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46187876
51neuron recognition (GO:0008038)3.45628503
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43908678
53exploration behavior (GO:0035640)3.41506367
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40210546
55cell communication by electrical coupling (GO:0010644)3.39354497
56cerebellar granule cell differentiation (GO:0021707)3.38729404
57positive regulation of membrane potential (GO:0045838)3.37163876
58neuronal ion channel clustering (GO:0045161)3.36776882
59fatty acid elongation (GO:0030497)3.36623123
60long-term memory (GO:0007616)3.36225308
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34937217
62negative regulation of neurotransmitter secretion (GO:0046929)3.34050484
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33458730
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31232400
65regulation of synapse structural plasticity (GO:0051823)3.27582477
66cellular sodium ion homeostasis (GO:0006883)3.25540525
67regulation of postsynaptic membrane potential (GO:0060078)3.25272902
68regulation of ARF protein signal transduction (GO:0032012)3.24306156
69establishment of mitochondrion localization (GO:0051654)3.20373653
70neurotransmitter transport (GO:0006836)3.19173938
71acidic amino acid transport (GO:0015800)3.17624193
72positive regulation of neurotransmitter transport (GO:0051590)3.17315222
73glycine transport (GO:0015816)3.15417311
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15167925
75neuromuscular synaptic transmission (GO:0007274)3.14486240
76long-term synaptic potentiation (GO:0060291)3.14353637
77positive regulation of neurotransmitter secretion (GO:0001956)3.12191396
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11124649
79regulation of synaptic plasticity (GO:0048167)3.10660953
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.09942331
81axonal fasciculation (GO:0007413)3.07816638
82regulation of dendritic spine morphogenesis (GO:0061001)3.07316935
83membrane hyperpolarization (GO:0060081)3.06050874
84neuromuscular process controlling posture (GO:0050884)3.05646203
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.05052130
86regulation of glutamate secretion (GO:0014048)3.05038935
87positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04014254
88regulation of voltage-gated calcium channel activity (GO:1901385)3.02756128
89auditory behavior (GO:0031223)3.02640174
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00818560
91regulation of calcium ion-dependent exocytosis (GO:0017158)3.00723654
92negative regulation of dendrite morphogenesis (GO:0050774)3.00245906
93negative regulation of dendrite development (GO:2000171)2.99373574
94layer formation in cerebral cortex (GO:0021819)2.98696244
95regulation of neurotransmitter secretion (GO:0046928)2.98106160
96dendrite morphogenesis (GO:0048813)2.97329197
97chemosensory behavior (GO:0007635)2.95354609
98regulation of synaptic transmission (GO:0050804)2.94622180
99synaptic transmission (GO:0007268)2.93334325
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93038948
101regulation of neurotransmitter levels (GO:0001505)2.92648499
102postsynaptic membrane organization (GO:0001941)2.91064364
103synaptic vesicle transport (GO:0048489)2.90803864
104establishment of synaptic vesicle localization (GO:0097480)2.90803864
105cell communication involved in cardiac conduction (GO:0086065)2.89971311
106synaptic vesicle endocytosis (GO:0048488)2.89681000
107regulation of vesicle fusion (GO:0031338)2.89677666
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88640794
109membrane depolarization (GO:0051899)2.87854554
110neuromuscular process controlling balance (GO:0050885)2.87720903
111cellular potassium ion homeostasis (GO:0030007)2.86863748
112mechanosensory behavior (GO:0007638)2.84712040
113regulation of neurotransmitter transport (GO:0051588)2.82942052
114learning (GO:0007612)2.82486128
115cerebellar Purkinje cell differentiation (GO:0021702)2.82269359
116apical protein localization (GO:0045176)2.81835803
117negative regulation of amino acid transport (GO:0051956)2.81450679
118neurotransmitter uptake (GO:0001504)2.80809940
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.77357126
120regulation of collateral sprouting (GO:0048670)2.77046437
121negative regulation of axonogenesis (GO:0050771)2.76561846
122amino acid import (GO:0043090)2.76394273
123regulation of dendritic spine development (GO:0060998)2.76031411
124mating behavior (GO:0007617)2.74461006
125behavioral response to cocaine (GO:0048148)2.74102219
126response to auditory stimulus (GO:0010996)2.73647623
127startle response (GO:0001964)2.73617474
128negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73412630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.06510531
2GBX2_23144817_ChIP-Seq_PC3_Human3.95271724
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02205944
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95921759
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88721857
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57852910
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57852910
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47725431
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44160725
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.43289812
11REST_21632747_ChIP-Seq_MESCs_Mouse2.39957028
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39561261
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39278615
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36406424
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35499209
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.28122223
17TAF15_26573619_Chip-Seq_HEK293_Human2.28012115
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.25603952
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.25034210
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16001080
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14504846
22AR_21572438_ChIP-Seq_LNCaP_Human2.09407816
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.03651102
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97265140
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.94592318
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83493319
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80916502
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79030222
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78181300
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74271346
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67042033
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66482346
33SMAD4_21799915_ChIP-Seq_A2780_Human1.61597201
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60716448
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60434154
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58820979
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56762317
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55784076
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52939991
40P300_19829295_ChIP-Seq_ESCs_Human1.52675390
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52478147
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51470554
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.50504722
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42180925
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.41305566
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41166705
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38107097
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.37572451
49* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36573120
50STAT3_23295773_ChIP-Seq_U87_Human1.31232180
51ER_23166858_ChIP-Seq_MCF-7_Human1.30888261
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29836773
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29681208
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28713424
55KDM2B_26808549_Chip-Seq_K562_Human1.27979747
56* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26487977
57TET1_21490601_ChIP-Seq_MESCs_Mouse1.26194474
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.25003306
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.24312576
60FUS_26573619_Chip-Seq_HEK293_Human1.22936621
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22532105
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21350287
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20200370
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19107814
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18688589
66AR_25329375_ChIP-Seq_VCAP_Human1.18186540
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17779723
68TCF4_23295773_ChIP-Seq_U87_Human1.17179711
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16988221
70RNF2_27304074_Chip-Seq_NSC_Mouse1.16322310
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16217126
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15312143
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15165999
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14822562
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12479847
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.12293889
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11651619
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10365242
79ZNF274_21170338_ChIP-Seq_K562_Hela1.10280655
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.10026396
81VDR_22108803_ChIP-Seq_LS180_Human1.08646755
82CTCF_27219007_Chip-Seq_Bcells_Human1.08481428
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07982158
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06722083
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.06297754
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.06262452
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05273610
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04946752
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04467502
90AHR_22903824_ChIP-Seq_MCF-7_Human1.04384876
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03820936
92AR_19668381_ChIP-Seq_PC3_Human1.02602357
93RUNX2_22187159_ChIP-Seq_PCA_Human1.02453852
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.01348390
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99587241
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99336003
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.98725993
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98685254
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95592177
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95193216
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.94882696
102IGF1R_20145208_ChIP-Seq_DFB_Human0.94370343
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93856363
104TP53_16413492_ChIP-PET_HCT116_Human0.93194725
105JUN_21703547_ChIP-Seq_K562_Human0.92706901
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92701054
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.90744736
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89584516
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.89116353
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.89048428
111* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87565327
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87310254
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86837364
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86803293
115KDM2B_26808549_Chip-Seq_REH_Human0.86730975
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.85629031
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85526643
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85402132
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85402132
120OCT4_19829295_ChIP-Seq_ESCs_Human0.84633053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.41943552
2MP0003880_abnormal_central_pattern5.22669217
3MP0004270_analgesia3.88088075
4MP0003635_abnormal_synaptic_transmissio3.69573375
5MP0009745_abnormal_behavioral_response3.29949325
6MP0002064_seizures3.19635132
7MP0009046_muscle_twitch3.03535730
8MP0002272_abnormal_nervous_system2.95525548
9MP0002063_abnormal_learning/memory/cond2.94104578
10MP0002822_catalepsy2.76108039
11MP0005423_abnormal_somatic_nervous2.75829391
12MP0001486_abnormal_startle_reflex2.75809913
13MP0001968_abnormal_touch/_nociception2.70189971
14MP0002572_abnormal_emotion/affect_behav2.65407220
15MP0002734_abnormal_mechanical_nocicepti2.63648464
16MP0000920_abnormal_myelination2.46535864
17MP0002735_abnormal_chemical_nociception2.23639755
18MP0001440_abnormal_grooming_behavior2.21144710
19MP0001529_abnormal_vocalization2.19248054
20MP0002736_abnormal_nociception_after2.12005517
21MP0003329_amyloid_beta_deposits2.10539847
22MP0001501_abnormal_sleep_pattern2.10061579
23MP0000778_abnormal_nervous_system2.03547436
24MP0001970_abnormal_pain_threshold2.02524240
25MP0002067_abnormal_sensory_capabilities1.96258069
26MP0004142_abnormal_muscle_tone1.96079058
27MP0002733_abnormal_thermal_nociception1.94125374
28MP0001905_abnormal_dopamine_level1.93922932
29MP0004885_abnormal_endolymph1.88030488
30MP0008569_lethality_at_weaning1.78953874
31MP0004924_abnormal_behavior1.74514599
32MP0005386_behavior/neurological_phenoty1.74514599
33MP0003690_abnormal_glial_cell1.73162959
34MP0000955_abnormal_spinal_cord1.63819209
35MP0002184_abnormal_innervation1.59659427
36MP0004742_abnormal_vestibular_system1.58985702
37MP0003123_paternal_imprinting1.55358812
38MP0002557_abnormal_social/conspecific_i1.51474398
39MP0002066_abnormal_motor_capabilities/c1.50442854
40MP0002882_abnormal_neuron_morphology1.50247349
41MP0005646_abnormal_pituitary_gland1.45599150
42MP0003633_abnormal_nervous_system1.45105104
43MP0004811_abnormal_neuron_physiology1.44195213
44MP0006276_abnormal_autonomic_nervous1.42981795
45MP0003634_abnormal_glial_cell1.39865429
46MP0002229_neurodegeneration1.37425959
47MP0003631_nervous_system_phenotype1.35620017
48MP0001984_abnormal_olfaction1.35281878
49MP0003787_abnormal_imprinting1.33226664
50MP0005409_darkened_coat_color1.28734480
51MP0001485_abnormal_pinna_reflex1.28296446
52MP0009780_abnormal_chondrocyte_physiolo1.26657259
53MP0005645_abnormal_hypothalamus_physiol1.25539196
54MP0005171_absent_coat_pigmentation1.23158905
55MP0005551_abnormal_eye_electrophysiolog1.20770625
56MP0003632_abnormal_nervous_system1.20495440
57MP0004145_abnormal_muscle_electrophysio1.18406630
58MP0003879_abnormal_hair_cell1.11216315
59MP0001188_hyperpigmentation1.10987761
60MP0001502_abnormal_circadian_rhythm1.10676240
61MP0003122_maternal_imprinting1.09965765
62MP0004858_abnormal_nervous_system1.09051263
63MP0002152_abnormal_brain_morphology1.05904152
64MP0001963_abnormal_hearing_physiology1.00452063
65MP0001177_atelectasis0.98870141
66MP0004043_abnormal_pH_regulation0.98781901
67MP0005410_abnormal_fertilization0.98727994
68MP0000604_amyloidosis0.95747583
69MP0003283_abnormal_digestive_organ0.95489367
70MP0002752_abnormal_somatic_nervous0.94964909
71MP0002638_abnormal_pupillary_reflex0.93120368
72MP0002909_abnormal_adrenal_gland0.88347342
73MP0000751_myopathy0.87288656
74MP0002069_abnormal_eating/drinking_beha0.84083910
75MP0008877_abnormal_DNA_methylation0.82370726
76MP0003121_genomic_imprinting0.82327352
77MP0003183_abnormal_peptide_metabolism0.81785528
78MP0001299_abnormal_eye_distance/0.81766485
79MP0008874_decreased_physiological_sensi0.81244998
80MP0008872_abnormal_physiological_respon0.81122614
81MP0004130_abnormal_muscle_cell0.80339475
82MP0004085_abnormal_heartbeat0.78113420
83MP0001986_abnormal_taste_sensitivity0.77116890
84MP0000631_abnormal_neuroendocrine_gland0.73850922
85MP0000747_muscle_weakness0.72928122
86MP0005623_abnormal_meninges_morphology0.72857331
87MP0002090_abnormal_vision0.70515549
88MP0003137_abnormal_impulse_conducting0.66516789
89MP0010386_abnormal_urinary_bladder0.65631495
90MP0005167_abnormal_blood-brain_barrier0.63010082
91MP0003950_abnormal_plasma_membrane0.62755064
92MP0005535_abnormal_body_temperature0.59990460
93MP0001664_abnormal_digestion0.58787432
94MP0001943_abnormal_respiration0.58290059
95MP0004215_abnormal_myocardial_fiber0.57254278
96MP0001346_abnormal_lacrimal_gland0.56972546
97MP0000026_abnormal_inner_ear0.56456085
98MP0000566_synostosis0.56446799
99MP0010768_mortality/aging0.55343882
100MP0003075_altered_response_to0.53636770
101MP0000579_abnormal_nail_morphology0.53126391
102MP0001348_abnormal_lacrimal_gland0.52395669
103MP0004147_increased_porphyrin_level0.52132474
104MP0005394_taste/olfaction_phenotype0.52129741
105MP0005499_abnormal_olfactory_system0.52129741
106MP0000462_abnormal_digestive_system0.52021880
107MP0003956_abnormal_body_size0.51902596
108MP0008260_abnormal_autophagy0.51645195
109MP0000013_abnormal_adipose_tissue0.50871692
110MP0002837_dystrophic_cardiac_calcinosis0.50264125
111MP0003861_abnormal_nervous_system0.49267635
112MP0010769_abnormal_survival0.48782767
113MP0005195_abnormal_posterior_eye0.48327165
114MP0010770_preweaning_lethality0.48145906
115MP0002082_postnatal_lethality0.48145906
116MP0006072_abnormal_retinal_apoptosis0.48030640
117MP0001731_abnormal_postnatal_growth0.48009897
118MP0003136_yellow_coat_color0.47116524

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51695155
2Myokymia (HP:0002411)6.30494452
3Focal seizures (HP:0007359)4.77648262
4Atonic seizures (HP:0010819)4.34983271
5Epileptic encephalopathy (HP:0200134)4.32299185
6Neurofibrillary tangles (HP:0002185)4.26925392
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.19639248
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.19639248
9Supranuclear gaze palsy (HP:0000605)4.08788160
10Abnormality of the corticospinal tract (HP:0002492)3.91748181
11Dysmetria (HP:0001310)3.68376231
12Visual hallucinations (HP:0002367)3.64825704
13Progressive cerebellar ataxia (HP:0002073)3.55849505
14Ankle clonus (HP:0011448)3.55524703
15Action tremor (HP:0002345)3.52176213
16Cerebral inclusion bodies (HP:0100314)3.49104184
17Broad-based gait (HP:0002136)3.38676135
18Spastic gait (HP:0002064)3.37861231
19Scanning speech (HP:0002168)3.34787869
20Absence seizures (HP:0002121)3.31813661
21Dialeptic seizures (HP:0011146)3.30016223
22Sensory axonal neuropathy (HP:0003390)3.26867643
23Peripheral hypomyelination (HP:0007182)3.24732420
24Febrile seizures (HP:0002373)3.20431217
25Intention tremor (HP:0002080)3.18343126
26Generalized tonic-clonic seizures (HP:0002069)3.18318744
27Hyperventilation (HP:0002883)3.07482814
28Gaze-evoked nystagmus (HP:0000640)3.05637927
29Dysdiadochokinesis (HP:0002075)3.03032622
30Obstructive sleep apnea (HP:0002870)3.00840398
31Pheochromocytoma (HP:0002666)3.00310425
32Termporal pattern (HP:0011008)2.92037605
33Insidious onset (HP:0003587)2.92037605
34Papilledema (HP:0001085)2.91832613
35Progressive inability to walk (HP:0002505)2.70702588
36Onion bulb formation (HP:0003383)2.67886633
37Anxiety (HP:0000739)2.63083244
38Status epilepticus (HP:0002133)2.62517892
39Truncal ataxia (HP:0002078)2.62478233
40Akinesia (HP:0002304)2.61568762
41Urinary bladder sphincter dysfunction (HP:0002839)2.60331381
42Tetraplegia (HP:0002445)2.58679832
43Neuroendocrine neoplasm (HP:0100634)2.58200223
44Abnormal eating behavior (HP:0100738)2.57417792
45Urinary urgency (HP:0000012)2.55606593
46Retinal dysplasia (HP:0007973)2.54962663
47Sleep apnea (HP:0010535)2.54633222
48Impaired vibration sensation in the lower limbs (HP:0002166)2.47525867
49Poor eye contact (HP:0000817)2.45582705
50Limb dystonia (HP:0002451)2.45388673
51Lower limb muscle weakness (HP:0007340)2.45339653
52Cerebral hypomyelination (HP:0006808)2.44352388
53Postural instability (HP:0002172)2.43224621
54Impaired smooth pursuit (HP:0007772)2.41982314
55Depression (HP:0000716)2.36454740
56Torticollis (HP:0000473)2.33293194
57Apathy (HP:0000741)2.32675832
58Amblyopia (HP:0000646)2.32257715
59Excessive salivation (HP:0003781)2.31115739
60Drooling (HP:0002307)2.31115739
61Bundle branch block (HP:0011710)2.29950350
62Abnormality of the lower motor neuron (HP:0002366)2.29742592
63Impaired vibratory sensation (HP:0002495)2.28723199
64Delusions (HP:0000746)2.28679364
65Generalized myoclonic seizures (HP:0002123)2.26473477
66Megalencephaly (HP:0001355)2.26079667
67Hemiplegia (HP:0002301)2.25203178
68Insomnia (HP:0100785)2.20049849
69Genetic anticipation (HP:0003743)2.19927242
70Hemiparesis (HP:0001269)2.19609243
71Impaired social interactions (HP:0000735)2.19270036
72Abnormal social behavior (HP:0012433)2.19270036
73Mutism (HP:0002300)2.17801047
74Annular pancreas (HP:0001734)2.16583365
75Clumsiness (HP:0002312)2.15117198
76Abnormality of binocular vision (HP:0011514)2.14162266
77Diplopia (HP:0000651)2.14162266
78Clonus (HP:0002169)2.12560362
79Choreoathetosis (HP:0001266)2.11282372
80Focal dystonia (HP:0004373)2.11180843
81Abnormality of ocular smooth pursuit (HP:0000617)2.09977883
82Fetal akinesia sequence (HP:0001989)2.08552697
83Diminished motivation (HP:0000745)2.07225071
84Blue irides (HP:0000635)2.07003540
85Epileptiform EEG discharges (HP:0011182)2.06751395
86Thickened helices (HP:0000391)1.99468396
87Leukodystrophy (HP:0002415)1.99430272
88Absent speech (HP:0001344)1.99326991
89Craniofacial dystonia (HP:0012179)1.98633032
90Gait imbalance (HP:0002141)1.98579355
91Metabolic alkalosis (HP:0200114)1.98129341
92Aplasia involving bones of the extremities (HP:0009825)1.96414752
93Aplasia involving bones of the upper limbs (HP:0009823)1.96414752
94Aplasia of the phalanges of the hand (HP:0009802)1.96414752
95Alacrima (HP:0000522)1.95514874
96EEG with generalized epileptiform discharges (HP:0011198)1.94758717
97Slow saccadic eye movements (HP:0000514)1.94734314
98Bradykinesia (HP:0002067)1.94671043
99Parakeratosis (HP:0001036)1.93779751
100Abnormality of saccadic eye movements (HP:0000570)1.92728971
101Rapidly progressive (HP:0003678)1.92689377
102Increased circulating renin level (HP:0000848)1.92268511
103Abnormal auditory evoked potentials (HP:0006958)1.90557405
104Vaginal atresia (HP:0000148)1.90268274
105Psychosis (HP:0000709)1.89952926
106Poor speech (HP:0002465)1.87938514
107Genital tract atresia (HP:0001827)1.87880958
108Type II lissencephaly (HP:0007260)1.87427456
109Specific learning disability (HP:0001328)1.87348316
110Spastic tetraparesis (HP:0001285)1.87224489
111Incomplete penetrance (HP:0003829)1.86058355
112Rigidity (HP:0002063)1.86011206
113Paraplegia (HP:0010550)1.85331671
114Neuronal loss in central nervous system (HP:0002529)1.85007325
115Hypsarrhythmia (HP:0002521)1.84897416
116Diminished movement (HP:0002374)1.84237743
117CNS hypomyelination (HP:0003429)1.84076237
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83813799
119Hand muscle atrophy (HP:0009130)1.82101079
120Inability to walk (HP:0002540)1.81465277
121Amyotrophic lateral sclerosis (HP:0007354)1.81047383
122Polyphagia (HP:0002591)1.80923849
123Hammertoe (HP:0001765)1.80721748
124Morphological abnormality of the pyramidal tract (HP:0002062)1.80698553
125Bowel incontinence (HP:0002607)1.80274595
126Stereotypic behavior (HP:0000733)1.76249010
127Dysmetric saccades (HP:0000641)1.74606079
128Muscular hypotonia of the trunk (HP:0008936)1.73357577
129Spastic paraplegia (HP:0001258)1.71463509
130Postural tremor (HP:0002174)1.70041170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.73961250
2NTRK33.65835264
3STK393.17649089
4OXSR12.89840343
5MAP3K92.69237674
6CASK2.58497421
7MAP3K42.46307125
8CDK192.40220239
9MARK12.31259302
10PRPF4B2.29941022
11TNIK2.26527490
12MAP2K72.22255077
13DAPK22.09131108
14PAK62.05649583
15NTRK11.98388376
16PINK11.97210620
17MINK11.94737632
18PNCK1.90327523
19KSR21.67609098
20NTRK21.58312284
21UHMK11.57248568
22BCR1.54575626
23CDK51.46579661
24MAPK131.43655783
25PKN11.42998014
26SGK2231.41057058
27SGK4941.41057058
28MAP2K41.38759085
29CAMK2B1.36879199
30ARAF1.28416397
31GRK51.27921334
32MAP3K121.27227283
33PLK21.24052008
34EPHB11.22327377
35WNK11.21575683
36FGFR21.19157939
37PRKD31.18618778
38CAMK2A1.18039455
39WNK41.17233922
40TYRO31.16139534
41MAPKAPK51.15628291
42NEK61.07730483
43CDK141.05863194
44CDK181.05571587
45RIPK41.04752438
46CDK151.04596595
47CSNK1G21.03755774
48FES1.02713815
49MAP3K20.98349458
50CAMK2D0.97608063
51PRKCG0.96946224
52MAP3K130.96792249
53CDK11A0.91957774
54CAMKK10.91481100
55RIPK10.91341788
56PHKG10.90122523
57PHKG20.90122523
58KSR10.89578039
59ROCK20.88330152
60CSNK1G30.86376172
61DAPK10.86373088
62PAK30.85947575
63MAPK100.83683835
64FGR0.83119306
65PTK2B0.82201877
66CAMK2G0.81970899
67CAMKK20.80253962
68LIMK10.78066203
69MARK20.77601516
70MAPK120.76210102
71CSNK1A1L0.75612198
72PRKCH0.72755463
73PRKCE0.72706487
74STK110.72447521
75PDPK10.70178517
76CAMK40.65930703
77AKT30.63926447
78CAMK10.63829783
79BMPR20.62833226
80SGK10.62313222
81ALK0.60800095
82CAMK1D0.60034363
83DYRK1A0.57580612
84LMTK20.57265871
85TESK10.56730279
86RET0.56468151
87SIK20.56407923
88IRAK20.55242321
89PDK10.55006341
90FYN0.55001706
91GRK70.54234091
92NME10.54218492
93CSNK1G10.53561357
94SGK20.53359359
95BRSK10.49658354
96STK380.48051142
97MET0.46315656
98CDK30.45330548
99MUSK0.44666356
100PRKAA10.44567959
101ADRBK20.44061499
102SGK30.42830360
103DAPK30.42187426
104PRKCQ0.40626218
105CAMK1G0.40516896
106MAP3K10.40359946
107TNK20.39828701
108PRKG10.39606384
109ICK0.39469810
110RPS6KA30.39435677
111LATS20.38093362
112GSK3B0.37213208
113CSNK1E0.36677983
114CSNK1D0.36068553
115CSNK1A10.35795311
116PRKACA0.35615813
117PRKCZ0.34632862
118MAPK80.34540873
119MAP2K10.33957031
120PRKD10.33049052
121WNK30.31954410

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42032586
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09810166
3GABAergic synapse_Homo sapiens_hsa047272.68224766
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62433296
5Glutamatergic synapse_Homo sapiens_hsa047242.61388743
6Circadian entrainment_Homo sapiens_hsa047132.50532067
7Morphine addiction_Homo sapiens_hsa050322.44274865
8Long-term potentiation_Homo sapiens_hsa047202.26874405
9Olfactory transduction_Homo sapiens_hsa047402.23906529
10Amphetamine addiction_Homo sapiens_hsa050312.19128577
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16473189
12Dopaminergic synapse_Homo sapiens_hsa047282.03156224
13Salivary secretion_Homo sapiens_hsa049701.97973388
14Collecting duct acid secretion_Homo sapiens_hsa049661.95335947
15Serotonergic synapse_Homo sapiens_hsa047261.87432350
16Long-term depression_Homo sapiens_hsa047301.82905675
17Cholinergic synapse_Homo sapiens_hsa047251.76533700
18Cocaine addiction_Homo sapiens_hsa050301.67542053
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66976055
20Insulin secretion_Homo sapiens_hsa049111.64331200
21Gastric acid secretion_Homo sapiens_hsa049711.63191756
22Taste transduction_Homo sapiens_hsa047421.60876013
23Renin secretion_Homo sapiens_hsa049241.59332743
24Axon guidance_Homo sapiens_hsa043601.57393336
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56527273
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45028957
27Calcium signaling pathway_Homo sapiens_hsa040201.39456629
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37895699
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37027969
30Oxytocin signaling pathway_Homo sapiens_hsa049211.35865125
31Vibrio cholerae infection_Homo sapiens_hsa051101.32354523
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31490611
33Steroid biosynthesis_Homo sapiens_hsa001001.30491440
34Oxidative phosphorylation_Homo sapiens_hsa001901.28494522
35Gap junction_Homo sapiens_hsa045401.23333346
36Fatty acid elongation_Homo sapiens_hsa000621.21685300
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20149471
38GnRH signaling pathway_Homo sapiens_hsa049121.16768780
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16360181
40Cardiac muscle contraction_Homo sapiens_hsa042601.15293234
41Ether lipid metabolism_Homo sapiens_hsa005651.15244242
42cAMP signaling pathway_Homo sapiens_hsa040241.11817253
43Alzheimers disease_Homo sapiens_hsa050101.08613705
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08066280
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02833700
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97202279
47ErbB signaling pathway_Homo sapiens_hsa040120.96942638
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96564044
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.95205980
50Histidine metabolism_Homo sapiens_hsa003400.93598876
51Phototransduction_Homo sapiens_hsa047440.91560165
52Parkinsons disease_Homo sapiens_hsa050120.89980005
53Type II diabetes mellitus_Homo sapiens_hsa049300.88102481
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.87939403
55Dorso-ventral axis formation_Homo sapiens_hsa043200.86152551
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85982280
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84979670
58Pancreatic secretion_Homo sapiens_hsa049720.84578899
59Estrogen signaling pathway_Homo sapiens_hsa049150.82299240
60Arginine and proline metabolism_Homo sapiens_hsa003300.81991400
61Melanogenesis_Homo sapiens_hsa049160.81092658
62Circadian rhythm_Homo sapiens_hsa047100.80867173
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80817912
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80267567
65Nitrogen metabolism_Homo sapiens_hsa009100.79236981
66Glucagon signaling pathway_Homo sapiens_hsa049220.76191016
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74763387
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73783075
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73378110
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73296125
71beta-Alanine metabolism_Homo sapiens_hsa004100.71657303
72Glioma_Homo sapiens_hsa052140.71144074
73Ras signaling pathway_Homo sapiens_hsa040140.70756426
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.70046196
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69979436
76Renal cell carcinoma_Homo sapiens_hsa052110.67752291
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63374000
78Choline metabolism in cancer_Homo sapiens_hsa052310.63362431
79MAPK signaling pathway_Homo sapiens_hsa040100.63350849
80Butanoate metabolism_Homo sapiens_hsa006500.62042901
81Arginine biosynthesis_Homo sapiens_hsa002200.60726654
82Ovarian steroidogenesis_Homo sapiens_hsa049130.58865713
83Endocytosis_Homo sapiens_hsa041440.58587161
84ABC transporters_Homo sapiens_hsa020100.57548942
85Thyroid hormone synthesis_Homo sapiens_hsa049180.55929077
86Dilated cardiomyopathy_Homo sapiens_hsa054140.55057985
87Rheumatoid arthritis_Homo sapiens_hsa053230.54748573
88AMPK signaling pathway_Homo sapiens_hsa041520.53369427
89Oocyte meiosis_Homo sapiens_hsa041140.51819025
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50314593
91Fatty acid biosynthesis_Homo sapiens_hsa000610.49248098
92mTOR signaling pathway_Homo sapiens_hsa041500.49223964
93Sphingolipid metabolism_Homo sapiens_hsa006000.48516713
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48323190
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.47372526
96Alcoholism_Homo sapiens_hsa050340.47310911
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.47145226
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46847496
99Huntingtons disease_Homo sapiens_hsa050160.45886996
100Rap1 signaling pathway_Homo sapiens_hsa040150.44401719
101Sulfur metabolism_Homo sapiens_hsa009200.42498005
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40391093
103Inositol phosphate metabolism_Homo sapiens_hsa005620.39750471
104Tight junction_Homo sapiens_hsa045300.39562938
105Vitamin B6 metabolism_Homo sapiens_hsa007500.39317184
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38382955
107Phenylalanine metabolism_Homo sapiens_hsa003600.37993003
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36085850
109Regulation of autophagy_Homo sapiens_hsa041400.35549452
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35276349
111Prion diseases_Homo sapiens_hsa050200.34704011
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34594780
113Insulin signaling pathway_Homo sapiens_hsa049100.33986965
114VEGF signaling pathway_Homo sapiens_hsa043700.32933775
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32827057
116Phagosome_Homo sapiens_hsa041450.32626220
117Mineral absorption_Homo sapiens_hsa049780.32305807
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32207441
119Bile secretion_Homo sapiens_hsa049760.31826124
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31662716
121Wnt signaling pathway_Homo sapiens_hsa043100.31509590
122Endometrial cancer_Homo sapiens_hsa052130.25701077

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