ITPKC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.77130848
2regulation of water loss via skin (GO:0033561)7.60851068
3establishment of skin barrier (GO:0061436)7.49125581
4interferon-gamma secretion (GO:0072643)6.05911720
5keratinocyte proliferation (GO:0043616)5.91433867
6keratinocyte differentiation (GO:0030216)5.52949046
7keratinization (GO:0031424)5.41146087
8multicellular organismal water homeostasis (GO:0050891)5.30449162
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.84694023
10hair cycle (GO:0042633)4.59647395
11molting cycle (GO:0042303)4.59647395
12negative regulation of keratinocyte proliferation (GO:0010839)4.52522062
13epidermal cell differentiation (GO:0009913)4.42886851
14water homeostasis (GO:0030104)4.38597603
15intestinal epithelial cell development (GO:0060576)4.27957176
16regulation of chemokine secretion (GO:0090196)4.10345366
17surfactant homeostasis (GO:0043129)4.04163498
18skin morphogenesis (GO:0043589)3.92799218
19negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.83765881
20activation of MAPKKK activity (GO:0000185)3.79033139
21ectoderm development (GO:0007398)3.71546492
22keratinocyte development (GO:0003334)3.71179317
23sphingoid metabolic process (GO:0046519)3.69537740
24intermediate filament organization (GO:0045109)3.63505727
25negative regulation of stress fiber assembly (GO:0051497)3.52110640
26peptide cross-linking (GO:0018149)3.51964426
27virion attachment to host cell (GO:0019062)3.50306468
28adhesion of symbiont to host cell (GO:0044650)3.50306468
29epidermis development (GO:0008544)3.49943834
30positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.47811161
31sphingosine metabolic process (GO:0006670)3.44026546
32protein localization to endosome (GO:0036010)3.38751679
33low-density lipoprotein particle clearance (GO:0034383)3.37913470
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.34929120
35wound healing, spreading of epidermal cells (GO:0035313)3.29277880
36regulation of p38MAPK cascade (GO:1900744)3.25773818
37epithelial cell-cell adhesion (GO:0090136)3.23508736
38regulation of membrane protein ectodomain proteolysis (GO:0051043)3.19312264
39response to muramyl dipeptide (GO:0032495)3.17420690
40diol metabolic process (GO:0034311)3.16949936
41detection of bacterium (GO:0016045)3.16360207
42positive regulation of epidermis development (GO:0045684)3.15802435
43epithelial cell differentiation involved in prostate gland development (GO:0060742)3.13654800
44positive regulation of epidermal cell differentiation (GO:0045606)3.12446083
45chemical homeostasis within a tissue (GO:0048875)3.11265001
46cell-substrate junction assembly (GO:0007044)3.09845417
47regulation of ruffle assembly (GO:1900027)2.97007174
48detection of other organism (GO:0098543)2.94259489
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.92655895
50negative regulation of cell fate specification (GO:0009996)2.86158960
51atrioventricular valve morphogenesis (GO:0003181)2.85722187
52cell differentiation involved in embryonic placenta development (GO:0060706)2.83948817
53regulation of interleukin-8 secretion (GO:2000482)2.83838647
54positive regulation of interleukin-8 secretion (GO:2000484)2.83001672
55adhesion of symbiont to host (GO:0044406)2.82643389
56cyclooxygenase pathway (GO:0019371)2.80042319
57regulation of transforming growth factor beta1 production (GO:0032908)2.79839335
58regulation of keratinocyte proliferation (GO:0010837)2.76851809
59branching involved in labyrinthine layer morphogenesis (GO:0060670)2.69334990
60endothelial cell chemotaxis (GO:0035767)2.69272858
61cell adhesion mediated by integrin (GO:0033627)2.69044569
62eyelid development in camera-type eye (GO:0061029)2.67445278
63regulation of phospholipase A2 activity (GO:0032429)2.67176695
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66380458
65epithelial structure maintenance (GO:0010669)2.66331126
66regulation of epidermis development (GO:0045682)2.66043681
67intestinal cholesterol absorption (GO:0030299)2.65796251
68positive regulation of p38MAPK cascade (GO:1900745)2.61373971
69response to laminar fluid shear stress (GO:0034616)2.60643124
70positive regulation by symbiont of host defense response (GO:0052509)2.57858412
71modulation by symbiont of host defense response (GO:0052031)2.57858412
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57858412
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57858412
74positive regulation by organism of defense response of other organism involved in symbiotic interact2.57858412
75modulation by symbiont of host immune response (GO:0052553)2.57858412
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.57667175
77regulation of T-helper 2 cell differentiation (GO:0045628)2.57147144
78regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.56564399
79positive regulation of keratinocyte differentiation (GO:0045618)2.55835748
80adherens junction assembly (GO:0034333)2.53604873
81gland morphogenesis (GO:0022612)2.52879424
82regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52471183
83wound healing, spreading of cells (GO:0044319)2.51656092
84decidualization (GO:0046697)2.49661183
85intestinal absorption (GO:0050892)2.47817089
86response to peptidoglycan (GO:0032494)2.47293556
87linoleic acid metabolic process (GO:0043651)2.47163892
88negative regulation of fatty acid transport (GO:2000192)2.46613628
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.44871441
90negative regulation of interleukin-8 production (GO:0032717)2.44067464
91regulation of podosome assembly (GO:0071801)2.43847804
92T-helper cell differentiation (GO:0042093)2.43470185
93CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.43470185
94positive regulation of hair follicle development (GO:0051798)2.43463465
95positive regulation of hair cycle (GO:0042635)2.43463465
96semaphorin-plexin signaling pathway (GO:0071526)2.43445364
97regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43096812
98amyloid precursor protein catabolic process (GO:0042987)2.42983272
99planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42547443
100positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.42023699
101negative regulation of viral release from host cell (GO:1902187)2.41546691
102cell-substrate adherens junction assembly (GO:0007045)2.41146495
103focal adhesion assembly (GO:0048041)2.41146495
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40772250
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40599746
106regulation of hair follicle development (GO:0051797)2.40538705
107regulation of vitamin D biosynthetic process (GO:0060556)2.40288731
108endocytic recycling (GO:0032456)2.40119073
109trophoblast giant cell differentiation (GO:0060707)2.39975495
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.39058486
111regulation of vitamin metabolic process (GO:0030656)2.38862735
112negative regulation of cell fate commitment (GO:0010454)2.38716081
113regulation of cholesterol homeostasis (GO:2000188)2.38668717
114G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36961518
115dorsal/ventral axis specification (GO:0009950)2.35309470
116Golgi transport vesicle coating (GO:0048200)2.35174453
117COPI coating of Golgi vesicle (GO:0048205)2.35174453
118barbed-end actin filament capping (GO:0051016)2.33802807
119positive regulation of cellular amide metabolic process (GO:0034250)2.33762503
120NIK/NF-kappaB signaling (GO:0038061)2.32833465
121mannose metabolic process (GO:0006013)2.32392864
122stress fiber assembly (GO:0043149)2.31892430
123regulation of cell proliferation involved in kidney development (GO:1901722)2.31713626
124vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31138845
125maintenance of gastrointestinal epithelium (GO:0030277)2.31076748
126response to progesterone (GO:0032570)2.30633726
127lipoxygenase pathway (GO:0019372)2.29898717
128face development (GO:0060324)2.29719858
129branching involved in mammary gland duct morphogenesis (GO:0060444)2.29713395
130prostaglandin metabolic process (GO:0006693)2.29652348
131prostanoid metabolic process (GO:0006692)2.29652348
132positive regulation of antigen processing and presentation (GO:0002579)2.28956620
133cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27698169
134negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26446982
135regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.25857726
136positive regulation of cholesterol efflux (GO:0010875)2.25487324
137macrophage activation involved in immune response (GO:0002281)2.24951540
138positive regulation of chemokine secretion (GO:0090197)2.24413524
139regulation of early endosome to late endosome transport (GO:2000641)2.24272906
140regulation of integrin activation (GO:0033623)2.24212430
141positive regulation of extracellular matrix organization (GO:1903055)2.24197786
142response to type I interferon (GO:0034340)2.23138355
143cellular response to type I interferon (GO:0071357)2.23084275
144type I interferon signaling pathway (GO:0060337)2.23084275
145negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.22666373
146negative regulation of interleukin-2 production (GO:0032703)2.22603395
147prostanoid biosynthetic process (GO:0046457)2.22550871
148prostaglandin biosynthetic process (GO:0001516)2.22550871
149regulation of heterotypic cell-cell adhesion (GO:0034114)2.22444314
150skin development (GO:0043588)2.22236946
151regulation of dendritic cell antigen processing and presentation (GO:0002604)2.22098886
152intermediate filament cytoskeleton organization (GO:0045104)2.21772523
153regulation of chemokine biosynthetic process (GO:0045073)2.21155137
154positive regulation of chemokine biosynthetic process (GO:0045080)2.19761610
155cell-cell junction maintenance (GO:0045217)2.18930680
156vascular endothelial growth factor signaling pathway (GO:0038084)2.16053520
157positive regulation of astrocyte differentiation (GO:0048711)2.15982750
158pinocytosis (GO:0006907)2.15766016
159negative regulation of erythrocyte differentiation (GO:0045647)2.15534502
160embryo implantation (GO:0007566)2.13880806
161regulation of viral release from host cell (GO:1902186)2.12408072
162germinal center formation (GO:0002467)2.12228294
163cellular response to virus (GO:0098586)2.11857313
164ovulation (GO:0030728)2.10443851
165basement membrane organization (GO:0071711)2.10070532
166desmosome organization (GO:0002934)10.6477088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.10258728
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.93349290
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90007806
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83455616
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.74475518
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42034252
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.36718545
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.34435300
9P63_26484246_Chip-Seq_KERATINOCYTES_Human2.30891395
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.30838921
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.30838921
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.29431638
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08480758
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.02546813
15TP63_17297297_ChIP-ChIP_HaCaT_Human13.8847789
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98116845
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97044855
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86344151
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.79739116
20VDR_21846776_ChIP-Seq_THP-1_Human1.75678351
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72628642
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68229179
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.68174574
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67208420
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64769107
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60964798
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57569856
28CJUN_26792858_Chip-Seq_BT549_Human1.57138524
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56050826
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.52516734
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.49271918
32KDM2B_26808549_Chip-Seq_DND41_Human1.49053612
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47154889
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46997555
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46506705
36ATF3_27146783_Chip-Seq_COLON_Human1.42955178
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42866493
38* KLF5_25053715_ChIP-Seq_YYC3_Human1.41603659
39SOX2_20726797_ChIP-Seq_SW620_Human1.38901061
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37501961
41GATA4_25053715_ChIP-Seq_YYC3_Human1.37294058
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35535272
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34596280
44* GATA6_25053715_ChIP-Seq_YYC3_Human1.33080223
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.32321833
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28943004
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.28448217
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.26099536
49* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25482977
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24381153
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21325378
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21325378
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21325378
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20869420
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20750455
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20232373
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18990775
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18832279
59VDR_24763502_ChIP-Seq_THP-1_Human1.18715669
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.18461894
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17336198
62AHR_22903824_ChIP-Seq_MCF-7_Human1.16909638
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.16751967
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14690190
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13990639
66CREB1_26743006_Chip-Seq_LNCaP_Human1.13832767
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12267111
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11520191
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11519062
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11298697
71CLOCK_20551151_ChIP-Seq_293T_Human1.11046413
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08952030
73SMC4_20622854_ChIP-Seq_HELA_Human1.08813873
74TP53_22127205_ChIP-Seq_IMR90_Human1.07071348
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.06180837
76TP53_16413492_ChIP-PET_HCT116_Human1.05753273
77TCF7_22412390_ChIP-Seq_EML_Mouse1.05339846
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.04478938
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.04478938
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03660101
81ZNF263_19887448_ChIP-Seq_K562_Human1.03592151
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.03378825
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.03271148
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03205243
85* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99779299
86GATA1_19941826_ChIP-Seq_K562_Human0.97689442
87TP63_23658742_ChIP-Seq_EP156T_Human0.97575914
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97479050
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96861847
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96059705
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95379455
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.94395973
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94230346
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93701457
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93069679
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92135072
97RXR_22108803_ChIP-Seq_LS180_Human0.91911879
98P68_20966046_ChIP-Seq_HELA_Human0.89998066
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89789154
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88914876
101* TP63_22573176_ChIP-Seq_HFKS_Human0.88743439
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86619990
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86499143
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85981961
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85854279
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85468015
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.84572881
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81491842
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80928051
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80594950
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76411479
112KDM2B_26808549_Chip-Seq_K562_Human0.76368517
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76081068
114EGR1_19032775_ChIP-ChIP_M12_Human0.76072181
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75519331
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.75231326
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74475999
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74458266
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.73215299
120BP1_19119308_ChIP-ChIP_Hs578T_Human0.72717310
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72140094
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.72116852
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.71968463
124TP53_18474530_ChIP-ChIP_U2OS_Human0.71723494
125* BRD4_25478319_ChIP-Seq_HGPS_Human0.71322810
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70972277
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70712948
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.70489537
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70251231
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.69362649
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.69144144
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.68727672
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.66727376
134LXR_22292898_ChIP-Seq_THP-1_Human0.66540378
135LXR_22158963_ChIP-Seq_LIVER_Mouse0.65516909
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.65198460
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.64742404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.03022608
2MP0002796_impaired_skin_barrier4.87349508
3MP0005275_abnormal_skin_tensile3.94294608
4MP0010234_abnormal_vibrissa_follicle3.75698770
5MP0002060_abnormal_skin_morphology3.35403355
6MP0000566_synostosis3.33942001
7MP0003453_abnormal_keratinocyte_physiol3.21650014
8MP0002254_reproductive_system_inflammat3.21648714
9MP0000383_abnormal_hair_follicle3.20074940
10MP0005501_abnormal_skin_physiology3.19644013
11MP0001216_abnormal_epidermal_layer3.00886787
12MP0003705_abnormal_hypodermis_morpholog2.91199964
13MP0002098_abnormal_vibrissa_morphology2.64229939
14MP0010678_abnormal_skin_adnexa2.62968114
15MP0004381_abnormal_hair_follicle2.60983751
16MP0000467_abnormal_esophagus_morphology2.50125154
17MP0010771_integument_phenotype2.34900343
18MP0003566_abnormal_cell_adhesion2.27787666
19MP0004947_skin_inflammation2.26852346
20MP0000579_abnormal_nail_morphology2.22958012
21MP0005058_abnormal_lysosome_morphology2.12038921
22MP0010352_gastrointestinal_tract_polyps2.07397669
23MP0000377_abnormal_hair_follicle1.99474597
24MP0000647_abnormal_sebaceous_gland1.91399311
25MP0005076_abnormal_cell_differentiation1.89549633
26MP0000762_abnormal_tongue_morphology1.73892015
27MP0004510_myositis1.71784172
28MP0005409_darkened_coat_color1.59998501
29MP0000427_abnormal_hair_cycle1.59996460
30MP0001191_abnormal_skin_condition1.59642608
31MP0009931_abnormal_skin_appearance1.55692223
32MP0004264_abnormal_extraembryonic_tissu1.55271108
33MP0005451_abnormal_body_composition1.52653810
34MP0009053_abnormal_anal_canal1.52323863
35MP0001958_emphysema1.44199864
36MP0002877_abnormal_melanocyte_morpholog1.39470156
37MP0005257_abnormal_intraocular_pressure1.39066805
38MP0001243_abnormal_dermal_layer1.38892854
39MP0002234_abnormal_pharynx_morphology1.38856209
40MP0002009_preneoplasia1.38643790
41MP0005666_abnormal_adipose_tissue1.37390411
42MP0005367_renal/urinary_system_phenotyp1.35953775
43MP0000516_abnormal_urinary_system1.35953775
44MP0004858_abnormal_nervous_system1.32769022
45MP0005023_abnormal_wound_healing1.32217240
46MP0001346_abnormal_lacrimal_gland1.31607628
47MP0001849_ear_inflammation1.30836455
48MP0005375_adipose_tissue_phenotype1.30749644
49MP0008260_abnormal_autophagy1.25013343
50MP0003436_decreased_susceptibility_to1.22928843
51MP0003075_altered_response_to1.22782580
52MP0008438_abnormal_cutaneous_collagen1.21331003
53MP0000367_abnormal_coat/_hair1.19789880
54MP0006082_CNS_inflammation1.17672857
55MP0010155_abnormal_intestine_physiology1.16407154
56MP0008004_abnormal_stomach_pH1.15687612
57MP0005164_abnormal_response_to1.14762765
58MP0003300_gastrointestinal_ulcer1.14414930
59MP0004185_abnormal_adipocyte_glucose1.14008355
60MP0001851_eye_inflammation1.12942149
61MP0002332_abnormal_exercise_endurance1.11780513
62MP0000678_abnormal_parathyroid_gland1.10497938
63MP0005508_abnormal_skeleton_morphology1.06302301
64MP0002139_abnormal_hepatobiliary_system1.05838758
65MP0003279_aneurysm1.05398858
66MP0000627_abnormal_mammary_gland1.02386674
67MP0000003_abnormal_adipose_tissue0.99939433
68MP0005166_decreased_susceptibility_to0.98191896
69MP0010030_abnormal_orbit_morphology0.96802154
70MP0002006_tumorigenesis0.95338730
71MP0003303_peritoneal_inflammation0.94552271
72MP0005025_abnormal_response_to0.92301447
73MP0003329_amyloid_beta_deposits0.91572399
74MP0000767_abnormal_smooth_muscle0.90780709
75MP0005083_abnormal_biliary_tract0.88596232
76MP0002896_abnormal_bone_mineralization0.88048306
77MP0000343_altered_response_to0.86684217
78MP0002166_altered_tumor_susceptibility0.85774944
79MP0000537_abnormal_urethra_morphology0.85080075
80MP0000465_gastrointestinal_hemorrhage0.84967997
81MP0002419_abnormal_innate_immunity0.84552082
82MP0001542_abnormal_bone_strength0.84058352
83MP0002132_abnormal_respiratory_system0.83685766
84MP0000604_amyloidosis0.83297358
85MP0005165_increased_susceptibility_to0.82648891
86MP0003315_abnormal_perineum_morphology0.82276762
87MP0005390_skeleton_phenotype0.81505934
88MP0004019_abnormal_vitamin_homeostasis0.81118416
89MP0010368_abnormal_lymphatic_system0.80457014
90MP0002277_abnormal_respiratory_mucosa0.80012715
91MP0003950_abnormal_plasma_membrane0.79127579
92MP0000858_altered_metastatic_potential0.78730904
93MP0004782_abnormal_surfactant_physiolog0.78589601
94MP0003763_abnormal_thymus_physiology0.77970745
95MP0002111_abnormal_tail_morphology0.77445622
96MP0001666_abnormal_nutrient_absorption0.76621919
97MP0001340_abnormal_eyelid_morphology0.74505542
98MP0005503_abnormal_tendon_morphology0.74131071
99MP0003191_abnormal_cellular_cholesterol0.72511566
100MP0000490_abnormal_crypts_of0.71751053
101MP0002089_abnormal_postnatal_growth/wei0.71723797
102MP0002148_abnormal_hypersensitivity_rea0.71718279
103MP0003828_pulmonary_edema0.71405371
104MP0009764_decreased_sensitivity_to0.71399263
105MP0000477_abnormal_intestine_morphology0.70718458
106MP0003866_abnormal_defecation0.69826393
107MP0002933_joint_inflammation0.68386292
108MP0000249_abnormal_blood_vessel0.68240081
109MP0004272_abnormal_basement_membrane0.67587952
110MP0000750_abnormal_muscle_regeneration0.67488216
111MP0009333_abnormal_splenocyte_physiolog0.67032824
112MP0004883_abnormal_blood_vessel0.66566820
113MP0009278_abnormal_bone_marrow0.66486489
114MP0001545_abnormal_hematopoietic_system0.65888815
115MP0005397_hematopoietic_system_phenotyp0.65888815
116MP0003045_fibrosis0.65349885
117MP0005595_abnormal_vascular_smooth0.65164792
118MP0003448_altered_tumor_morphology0.64488901
119MP0003091_abnormal_cell_migration0.62470563
120MP0000470_abnormal_stomach_morphology0.62356478
121MP0001533_abnormal_skeleton_physiology0.59465683
122MP0000733_abnormal_muscle_development0.59355166
123MP0000538_abnormal_urinary_bladder0.59243836
124MP0002998_abnormal_bone_remodeling0.59047260
125MP0005387_immune_system_phenotype0.58404361
126MP0001790_abnormal_immune_system0.58404361
127MP0002697_abnormal_eye_size0.58395761
128MP0003724_increased_susceptibility_to0.57918769
129MP0003755_abnormal_palate_morphology0.57311644
130MP0002177_abnormal_outer_ear0.57239510
131MP0000432_abnormal_head_morphology0.56775770
132MP0009840_abnormal_foam_cell0.56562820
133MP0006054_spinal_hemorrhage0.53442282
134MP0008789_abnormal_olfactory_epithelium0.52814880
135MP0000613_abnormal_salivary_gland0.50824799
136MP0009785_altered_susceptibility_to0.45369421
137MP0005000_abnormal_immune_tolerance0.44193659
138MP0001800_abnormal_humoral_immune0.44093253
139MP0002452_abnormal_antigen_presenting0.43451242

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)6.19820527
2Lip pit (HP:0100267)5.96036578
3Plantar hyperkeratosis (HP:0007556)5.41843973
4Thick nail (HP:0001805)4.95593823
5Right ventricular cardiomyopathy (HP:0011663)4.78396222
6Hypotrichosis (HP:0001006)4.73377840
7Palmoplantar hyperkeratosis (HP:0000972)4.61658598
8Fragile nails (HP:0001808)4.58193036
9Palmar hyperkeratosis (HP:0010765)4.38935642
10Alopecia of scalp (HP:0002293)4.30464255
11Onycholysis (HP:0001806)4.19967219
12Atrophic scars (HP:0001075)4.19185880
13Popliteal pterygium (HP:0009756)4.02221985
14Woolly hair (HP:0002224)3.87109777
15Parakeratosis (HP:0001036)3.57033211
16Nail dystrophy (HP:0008404)3.47929863
17Hypoplastic labia majora (HP:0000059)3.43851453
18Abnormal blistering of the skin (HP:0008066)3.37810175
19Pili torti (HP:0003777)3.23721277
20Pustule (HP:0200039)3.19559823
21Interstitial pulmonary disease (HP:0006530)3.18027370
22Ectropion (HP:0000656)3.13851504
23Abnormality of the labia majora (HP:0012881)3.12177965
24Fatigable weakness (HP:0003473)3.10681886
25Abnormality of the neuromuscular junction (HP:0003398)3.10681886
26Congenital ichthyosiform erythroderma (HP:0007431)3.09827800
27Distal lower limb muscle weakness (HP:0009053)3.04931779
28Thin bony cortex (HP:0002753)2.91828619
29Increased IgE level (HP:0003212)2.88947570
30Abnormality of nail color (HP:0100643)2.83343041
31Hypohidrosis (HP:0000966)2.82290312
32Oligodontia (HP:0000677)2.81927929
33Malnutrition (HP:0004395)2.80027259
34Natal tooth (HP:0000695)2.72462121
35Protrusio acetabuli (HP:0003179)2.71873883
36Increased connective tissue (HP:0009025)2.69386926
37Axonal loss (HP:0003447)2.68028139
38Erythema (HP:0010783)2.66771805
39Systemic lupus erythematosus (HP:0002725)2.66514071
40Abnormality of the salivary glands (HP:0010286)2.66250518
41Pterygium (HP:0001059)2.64998306
42Abnormality of glycolipid metabolism (HP:0010969)2.62039338
43Abnormality of liposaccharide metabolism (HP:0010968)2.62039338
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.62039338
45Corneal erosion (HP:0200020)2.60208548
46Fragile skin (HP:0001030)2.60133804
47Gangrene (HP:0100758)2.59197522
48Ridged nail (HP:0001807)2.57190576
49Aplasia cutis congenita (HP:0001057)2.55260038
50Premature rupture of membranes (HP:0001788)2.54880754
51Cervical subluxation (HP:0003308)2.54602970
52Hypoplasia of dental enamel (HP:0006297)2.53211489
53Abnormality of the distal phalanges of the toes (HP:0010182)2.52922755
54Neurofibrillary tangles (HP:0002185)2.50532356
55Erythroderma (HP:0001019)2.48840583
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45524370
57Sparse eyelashes (HP:0000653)2.43924125
58Dysostosis multiplex (HP:0000943)2.34518141
59Sparse scalp hair (HP:0002209)2.34281257
60Short nail (HP:0001799)2.30828893
61Advanced eruption of teeth (HP:0006288)2.25487611
62Distal lower limb amyotrophy (HP:0008944)2.22982862
63Abnormality of complement system (HP:0005339)2.21575347
64Curly hair (HP:0002212)2.20554289
65Orchitis (HP:0100796)2.20149942
66Upper limb muscle weakness (HP:0003484)2.19028881
67Vertebral compression fractures (HP:0002953)2.16925724
68Pruritus (HP:0000989)2.11014989
69Abnormality of the gastric mucosa (HP:0004295)2.09388875
70Cerebral inclusion bodies (HP:0100314)2.09121740
71Broad face (HP:0000283)2.08562744
72Complement deficiency (HP:0004431)2.06987719
73Flat acetabular roof (HP:0003180)2.06892844
74Anhidrosis (HP:0000970)2.05701820
75Glomerulonephritis (HP:0000099)2.05628644
76Hyperparathyroidism (HP:0000843)2.04781917
77Blepharitis (HP:0000498)2.03600412
78Urethral obstruction (HP:0000796)2.02749042
79Acanthosis nigricans (HP:0000956)2.02717411
80Skin pits (HP:0100276)2.02456228
81Hemorrhage of the eye (HP:0011885)2.00856661
82Loss of speech (HP:0002371)2.00349911
83Premature loss of primary teeth (HP:0006323)1.98432768
84Ulnar bowing (HP:0003031)1.98310632
85Peritonitis (HP:0002586)1.97110317
86Labial hypoplasia (HP:0000066)1.95330833
87Segmental peripheral demyelination/remyelination (HP:0003481)1.94651898
88Achilles tendon contracture (HP:0001771)1.93714164
89Abnormality of the nasal mucosa (HP:0000433)1.93628117
90Nuclear cataract (HP:0100018)1.93505676
91Mucopolysacchariduria (HP:0008155)1.91382798
92Urinary glycosaminoglycan excretion (HP:0003541)1.91382798
93Abnormal hair laboratory examination (HP:0003328)1.90406601
94Abnormality of the labia (HP:0000058)1.90355137
95Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90163242
96Abnormality of polysaccharide metabolism (HP:0011012)1.90163242
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90163242
98Amyloidosis (HP:0011034)1.90051112
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89417646
100Ureteral duplication (HP:0000073)1.89134979
101Dehydration (HP:0001944)1.88370335
102Ventricular tachycardia (HP:0004756)1.88133990
103Myocardial infarction (HP:0001658)1.86013656
104Follicular hyperkeratosis (HP:0007502)1.84496563
105Deep venous thrombosis (HP:0002625)1.84357997
106Aneurysm (HP:0002617)1.82487432
107Upper limb amyotrophy (HP:0009129)1.82273241
108Distal upper limb amyotrophy (HP:0007149)1.82273241
109Abnormality of the Achilles tendon (HP:0005109)1.81253181
110Hypoplastic female external genitalia (HP:0012815)1.80989413
111Skin ulcer (HP:0200042)1.78594161
112Vacuolated lymphocytes (HP:0001922)1.78117201
113Optic neuritis (HP:0100653)1.77722851
114Retrobulbar optic neuritis (HP:0100654)1.77722851
115Abnormality of macrophages (HP:0004311)1.77240494
116Obstructive sleep apnea (HP:0002870)1.76874622
117Vascular tortuosity (HP:0004948)1.76210047
118Palmoplantar keratoderma (HP:0000982)1.75403866
119Nephritis (HP:0000123)1.74944698
120Increased cerebral lipofuscin (HP:0011813)1.73615782
121Asymmetric septal hypertrophy (HP:0001670)1.73181018
122Down-sloping shoulders (HP:0200021)1.72567985
123Arterial tortuosity (HP:0005116)1.71961185
124Oral leukoplakia (HP:0002745)1.71383979
125Blue sclerae (HP:0000592)1.70123090
126Elevated erythrocyte sedimentation rate (HP:0003565)1.69426171
127Nasal polyposis (HP:0100582)1.69386571
128Myositis (HP:0100614)1.68079679
129Absent eyebrow (HP:0002223)1.67065476
130Mitral regurgitation (HP:0001653)1.66861698
131Osteolytic defects of the hand bones (HP:0009699)1.66786543
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.66786543
133Cheilitis (HP:0100825)1.66262818
134Difficulty climbing stairs (HP:0003551)1.65819548
135Aortic aneurysm (HP:0004942)1.65499070
136Aortic dissection (HP:0002647)1.65300374
137Mildly elevated creatine phosphokinase (HP:0008180)1.61422593
138Conjunctival hamartoma (HP:0100780)1.61228645
139Hypodontia (HP:0000668)1.59362054
140Trismus (HP:0000211)1.59280532
141Ureteral obstruction (HP:0006000)1.57866855
142Dry skin (HP:0000958)1.56785195
143Eczematoid dermatitis (HP:0000976)1.56607806
144Abnormality of the nasal septum (HP:0000419)1.56257595
145Submucous cleft hard palate (HP:0000176)1.55943712
146Entropion (HP:0000621)1.55083779
147Cerebral aneurysm (HP:0004944)1.51775263
148Soft skin (HP:0000977)1.51495026
149Polygenic inheritance (HP:0010982)1.49827781
150Rectal prolapse (HP:0002035)1.49421059
151Prostate neoplasm (HP:0100787)1.49204859
152Shallow orbits (HP:0000586)1.48707865
153Periodontitis (HP:0000704)1.48452879
154Dilatation of the ascending aorta (HP:0005111)1.48439849
155Hypoplasia of the uterus (HP:0000013)1.47632029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.98972857
2MAP3K34.56472928
3MST1R3.51949136
4LATS12.80770615
5MAPKAPK32.49029815
6MAP3K142.47141286
7PRPF4B2.41805288
8SIK12.37644774
9ERN12.35628668
10MST42.35280441
11EPHB22.02527440
12RPS6KA42.00315266
13RPS6KB21.98645497
14FRK1.96692136
15FGFR41.90370257
16EEF2K1.85229597
17TGFBR21.84700089
18MAP3K21.77075232
19SMG11.76067400
20NME21.73645213
21CDK121.64388182
22FER1.60287338
23STK101.56983365
24ICK1.52941529
25TBK11.52915382
26EPHA31.52697650
27CDC42BPA1.51118937
28CHUK1.48169538
29IKBKE1.47803365
30TRPM71.47268949
31PIM21.44580064
32IKBKB1.43405714
33MAP2K31.36037952
34TAOK11.35503892
35TYK21.31729339
36IRAK31.27040698
37DMPK1.25401674
38PTK61.25303054
39PAK41.23925177
40MAP3K61.19310010
41PKN21.19037649
42RIPK11.16913032
43MET1.16705131
44MAP3K71.15615002
45TESK11.14863139
46NUAK11.14823159
47MAPK151.14127991
48EIF2AK21.03909579
49FGFR31.02146435
50TAOK21.01835378
51STK38L1.00413823
52PRKD20.99108684
53MAP3K100.97739084
54STK30.97392870
55ERBB30.96712796
56LMTK20.94893829
57STK380.88721307
58RPS6KA20.87854723
59MAP2K20.87667877
60MARK20.87311984
61PIM10.87161826
62NLK0.85200493
63JAK30.84676903
64MAP3K110.84119783
65ABL20.82007763
66BLK0.80325660
67MAPKAPK20.79053235
68EPHB10.79012520
69PTK20.77494355
70MAP3K130.77235436
71CDK30.75865185
72CDK60.75436200
73ARAF0.74143006
74ZAK0.71256303
75ZAP700.70403444
76MATK0.69661940
77PDGFRB0.69386301
78PRKCI0.68860457
79MAP3K90.68291091
80TSSK60.66939869
81TRIB30.66597512
82NTRK10.66555596
83LATS20.66290416
84PDPK10.66188783
85IRAK10.66082122
86JAK10.65950990
87IRAK20.65308524
88FGFR20.64990667
89RPS6KC10.64507497
90RPS6KL10.64507497
91GRK70.63847927
92IRAK40.62981128
93STK240.62738927
94MYLK0.60085319
95GSK3A0.59176432
96BMX0.58263649
97CDK90.57513818
98ERBB20.57436711
99ERBB40.56689956
100CAMK1D0.56477220
101PDGFRA0.55183077
102BMPR1B0.54878753
103LRRK20.54365832
104GRK10.54169572
105TTN0.53999065
106ITK0.53150509
107AKT30.52275229
108DAPK30.51146920
109MTOR0.50592928
110RIPK40.50380699
111NME10.49606516
112MAP3K10.49400467
113MAP4K10.49022993
114FGR0.47968013
115KSR20.45737668
116RPS6KA60.44390894
117MAPK40.42652621
118AURKB0.42551725
119HIPK20.42037449
120DDR20.41475736
121MAPKAPK50.41026459
122MARK30.40830156
123RPS6KA10.40613390
124CSK0.39621613
125JAK20.39321927
126MAPK70.39248220
127MAP3K50.39202571
128HCK0.39121471
129MAP3K80.38531407
130PIK3CG0.38178390
131PAK20.37611452
132RET0.37314828
133TXK0.36424303
134ABL10.35550928
135MAP2K60.35496271
136PRKAA20.34558617
137MOS0.34549060
138MAP2K10.34517547
139SGK30.33665273
140SIK30.33249876

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.34793942
2NF-kappa B signaling pathway_Homo sapiens_hsa040641.93474241
3Arachidonic acid metabolism_Homo sapiens_hsa005901.91624882
4Vitamin digestion and absorption_Homo sapiens_hsa049771.87288723
5TNF signaling pathway_Homo sapiens_hsa046681.84884318
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79441441
7Cyanoamino acid metabolism_Homo sapiens_hsa004601.79306614
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77768887
9ECM-receptor interaction_Homo sapiens_hsa045121.77089753
10Sphingolipid metabolism_Homo sapiens_hsa006001.70972265
11Toxoplasmosis_Homo sapiens_hsa051451.70688714
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67866132
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.66450926
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64732880
15Small cell lung cancer_Homo sapiens_hsa052221.62670260
16Prion diseases_Homo sapiens_hsa050201.62215988
17Fat digestion and absorption_Homo sapiens_hsa049751.61173070
18Legionellosis_Homo sapiens_hsa051341.56438781
19p53 signaling pathway_Homo sapiens_hsa041151.53016042
20Amoebiasis_Homo sapiens_hsa051461.52130044
21Adherens junction_Homo sapiens_hsa045201.49997598
22Leishmaniasis_Homo sapiens_hsa051401.49291250
23Malaria_Homo sapiens_hsa051441.48419246
24Linoleic acid metabolism_Homo sapiens_hsa005911.45817807
25MicroRNAs in cancer_Homo sapiens_hsa052061.45100040
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44917139
27Osteoclast differentiation_Homo sapiens_hsa043801.44702449
28Mineral absorption_Homo sapiens_hsa049781.40902498
29Basal cell carcinoma_Homo sapiens_hsa052171.34723287
30Lysosome_Homo sapiens_hsa041421.32606812
31Staphylococcus aureus infection_Homo sapiens_hsa051501.32525622
32Hippo signaling pathway_Homo sapiens_hsa043901.30270195
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27146128
34Hepatitis C_Homo sapiens_hsa051601.26967802
35Influenza A_Homo sapiens_hsa051641.24992935
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24426200
37Bladder cancer_Homo sapiens_hsa052191.23940184
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23875560
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21697808
40Complement and coagulation cascades_Homo sapiens_hsa046101.18632805
41Apoptosis_Homo sapiens_hsa042101.18380808
42Proteoglycans in cancer_Homo sapiens_hsa052051.17048924
43Pertussis_Homo sapiens_hsa051331.15903341
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14710753
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.13756322
46ABC transporters_Homo sapiens_hsa020101.12049931
47Protein digestion and absorption_Homo sapiens_hsa049741.08378969
48Hematopoietic cell lineage_Homo sapiens_hsa046401.07983517
49Fructose and mannose metabolism_Homo sapiens_hsa000511.07527501
50Acute myeloid leukemia_Homo sapiens_hsa052211.05976492
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04875645
52TGF-beta signaling pathway_Homo sapiens_hsa043501.03676162
53Galactose metabolism_Homo sapiens_hsa000521.02801884
54Antigen processing and presentation_Homo sapiens_hsa046120.99374861
55Renal cell carcinoma_Homo sapiens_hsa052110.98484473
56PPAR signaling pathway_Homo sapiens_hsa033200.98083045
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96544207
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96467495
59Chronic myeloid leukemia_Homo sapiens_hsa052200.94810948
60Notch signaling pathway_Homo sapiens_hsa043300.92721368
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92232063
62Insulin resistance_Homo sapiens_hsa049310.91331012
63Herpes simplex infection_Homo sapiens_hsa051680.90638537
64Tight junction_Homo sapiens_hsa045300.90106048
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89293832
66Tuberculosis_Homo sapiens_hsa051520.88884446
67African trypanosomiasis_Homo sapiens_hsa051430.88856635
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86475919
69HTLV-I infection_Homo sapiens_hsa051660.86269332
70Measles_Homo sapiens_hsa051620.84859417
71Prolactin signaling pathway_Homo sapiens_hsa049170.84755604
72ErbB signaling pathway_Homo sapiens_hsa040120.83641582
73Shigellosis_Homo sapiens_hsa051310.82258177
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81372424
75Graft-versus-host disease_Homo sapiens_hsa053320.80975544
76Primary immunodeficiency_Homo sapiens_hsa053400.80547859
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80054178
78Histidine metabolism_Homo sapiens_hsa003400.79829188
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.79417647
80Insulin signaling pathway_Homo sapiens_hsa049100.78956399
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.78893497
82Salmonella infection_Homo sapiens_hsa051320.78512175
83GnRH signaling pathway_Homo sapiens_hsa049120.77885085
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.77688283
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.77615324
86Focal adhesion_Homo sapiens_hsa045100.77469589
87Renin-angiotensin system_Homo sapiens_hsa046140.77095334
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76573737
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76273741
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76254769
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75847512
92FoxO signaling pathway_Homo sapiens_hsa040680.75381798
93Prostate cancer_Homo sapiens_hsa052150.71892513
94Chemical carcinogenesis_Homo sapiens_hsa052040.71777070
95Hepatitis B_Homo sapiens_hsa051610.71322087
96Endocytosis_Homo sapiens_hsa041440.69274090
97Hedgehog signaling pathway_Homo sapiens_hsa043400.68898563
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67615799
99Phenylalanine metabolism_Homo sapiens_hsa003600.66988185
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66001147
101Circadian rhythm_Homo sapiens_hsa047100.65603309
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65559035
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64926963
104Pathways in cancer_Homo sapiens_hsa052000.64044852
105Endometrial cancer_Homo sapiens_hsa052130.63418581
106Pancreatic cancer_Homo sapiens_hsa052120.62853483
107HIF-1 signaling pathway_Homo sapiens_hsa040660.61082443
108VEGF signaling pathway_Homo sapiens_hsa043700.60735744
109Retinol metabolism_Homo sapiens_hsa008300.60319506
110T cell receptor signaling pathway_Homo sapiens_hsa046600.59200421
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59031809
112Rheumatoid arthritis_Homo sapiens_hsa053230.58858215
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58623602
114mTOR signaling pathway_Homo sapiens_hsa041500.58038334
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.57856217
116Choline metabolism in cancer_Homo sapiens_hsa052310.57182472
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56742736
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53427209
119AMPK signaling pathway_Homo sapiens_hsa041520.53161411
120Viral carcinogenesis_Homo sapiens_hsa052030.51565147
121Non-small cell lung cancer_Homo sapiens_hsa052230.50394726
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50176339
123Vibrio cholerae infection_Homo sapiens_hsa051100.49342562
124MAPK signaling pathway_Homo sapiens_hsa040100.48980636
125Thyroid cancer_Homo sapiens_hsa052160.48660935
126Chemokine signaling pathway_Homo sapiens_hsa040620.48501366
127Glioma_Homo sapiens_hsa052140.48259839
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47910734
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46821101
130B cell receptor signaling pathway_Homo sapiens_hsa046620.46428477
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.45856051
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45416048
133Type II diabetes mellitus_Homo sapiens_hsa049300.45309663
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44943616
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44942385
136Ether lipid metabolism_Homo sapiens_hsa005650.44582755
137Platelet activation_Homo sapiens_hsa046110.44157110
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43443480

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