ITPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72514228
2ATP synthesis coupled proton transport (GO:0015986)5.26773841
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.26773841
4proteasome assembly (GO:0043248)4.64809800
5ribosomal small subunit biogenesis (GO:0042274)4.58598608
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.49190335
7maturation of SSU-rRNA (GO:0030490)4.35420880
8viral transcription (GO:0019083)4.33411284
9translational termination (GO:0006415)4.30228311
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.29019712
11protein maturation by protein folding (GO:0022417)4.28981754
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.21496856
13DNA strand elongation involved in DNA replication (GO:0006271)4.18083696
14cullin deneddylation (GO:0010388)4.16701732
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.14778578
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.14634334
17DNA replication initiation (GO:0006270)4.13767026
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.13563027
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11359762
20negative regulation of ligase activity (GO:0051352)4.11359762
21spliceosomal snRNP assembly (GO:0000387)4.10761424
22establishment of integrated proviral latency (GO:0075713)4.09592737
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.04647572
24termination of RNA polymerase III transcription (GO:0006386)4.04647572
25ribosomal small subunit assembly (GO:0000028)4.04126889
26DNA strand elongation (GO:0022616)3.98415731
27DNA deamination (GO:0045006)3.96678696
28nucleobase biosynthetic process (GO:0046112)3.94412202
29ribosomal large subunit biogenesis (GO:0042273)3.91422492
30formation of translation preinitiation complex (GO:0001731)3.90384203
31protein deneddylation (GO:0000338)3.89203915
32telomere maintenance via semi-conservative replication (GO:0032201)3.87787308
33purine nucleobase biosynthetic process (GO:0009113)3.85884432
34cotranslational protein targeting to membrane (GO:0006613)3.85848267
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.85594465
36translational elongation (GO:0006414)3.85558417
37regulation of cellular amino acid metabolic process (GO:0006521)3.82916652
38base-excision repair, AP site formation (GO:0006285)3.80312868
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.80016808
40protein targeting to ER (GO:0045047)3.78369520
41spliceosomal complex assembly (GO:0000245)3.76293966
42translational initiation (GO:0006413)3.76070800
43mitochondrial respiratory chain complex assembly (GO:0033108)3.72961225
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.70843336
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69933574
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.69571206
47chaperone-mediated protein transport (GO:0072321)3.66883895
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.63706471
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.63706471
50ribonucleoprotein complex biogenesis (GO:0022613)3.63597336
517-methylguanosine mRNA capping (GO:0006370)3.63176511
52translation (GO:0006412)3.61269986
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60684197
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60684197
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60684197
567-methylguanosine RNA capping (GO:0009452)3.60476630
57RNA capping (GO:0036260)3.60476630
58protein localization to endoplasmic reticulum (GO:0070972)3.60079577
59DNA replication checkpoint (GO:0000076)3.59879600
60cellular protein complex disassembly (GO:0043624)3.58916869
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58818221
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57668931
63oxidative phosphorylation (GO:0006119)3.57313548
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.56242820
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56242820
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.53335282
67positive regulation of ligase activity (GO:0051351)3.52669943
68protein localization to mitochondrion (GO:0070585)3.52167281
69pyrimidine nucleotide catabolic process (GO:0006244)3.51631240
70guanosine-containing compound biosynthetic process (GO:1901070)3.49214679
71GDP-mannose metabolic process (GO:0019673)3.49054427
72GTP biosynthetic process (GO:0006183)3.48486571
73CENP-A containing nucleosome assembly (GO:0034080)3.48375061
74DNA unwinding involved in DNA replication (GO:0006268)3.47907222
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47706507
76respiratory electron transport chain (GO:0022904)3.46526903
77viral life cycle (GO:0019058)3.45474169
78deoxyribonucleotide catabolic process (GO:0009264)3.45090770
79protein neddylation (GO:0045116)3.44968495
80DNA replication-dependent nucleosome assembly (GO:0006335)3.44693983
81DNA replication-dependent nucleosome organization (GO:0034723)3.44693983
82regulation of mitochondrial translation (GO:0070129)3.41477782
83deoxyribose phosphate catabolic process (GO:0046386)3.41341679
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40448821
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.40448821
86NADH dehydrogenase complex assembly (GO:0010257)3.40448821
87electron transport chain (GO:0022900)3.40056467
88chromatin remodeling at centromere (GO:0031055)3.38376899
89rRNA processing (GO:0006364)3.37479141
90ribosome assembly (GO:0042255)3.37454081
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37365064
92transcription-coupled nucleotide-excision repair (GO:0006283)3.37224822
93UTP biosynthetic process (GO:0006228)3.35321322
94establishment of protein localization to mitochondrion (GO:0072655)3.34651786
95metallo-sulfur cluster assembly (GO:0031163)3.33823872
96iron-sulfur cluster assembly (GO:0016226)3.33823872
97deoxyribonucleotide biosynthetic process (GO:0009263)3.33393716
98regulation of ubiquitin-protein transferase activity (GO:0051438)3.32873492
99cellular component biogenesis (GO:0044085)3.31900115
100cytochrome complex assembly (GO:0017004)3.31236986
101telomere maintenance via recombination (GO:0000722)3.27741911
102protein targeting to mitochondrion (GO:0006626)3.27319263
103establishment of viral latency (GO:0019043)3.26682036
104rRNA metabolic process (GO:0016072)3.25149716
105rRNA modification (GO:0000154)3.24710123
106RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24262430
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24262430
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22340056
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21487431
110respiratory chain complex IV assembly (GO:0008535)3.20676533
111pseudouridine synthesis (GO:0001522)3.19369517
112regulation of ligase activity (GO:0051340)3.19234283
113G1/S transition of mitotic cell cycle (GO:0000082)3.18525938
114cell cycle G1/S phase transition (GO:0044843)3.18525938
115protein complex biogenesis (GO:0070271)3.17796255
116ribosome biogenesis (GO:0042254)3.17760171
117nucleobase-containing small molecule interconversion (GO:0015949)3.17674296
118pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14991194
119DNA damage response, detection of DNA damage (GO:0042769)3.13517818
1202-deoxyribonucleotide biosynthetic process (GO:0009265)3.10510728
121deoxyribose phosphate biosynthetic process (GO:0046385)3.10510728
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07425231
123* deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.06762620
124transcription from mitochondrial promoter (GO:0006390)3.02744075
125positive regulation of cell cycle arrest (GO:0071158)2.98235533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72909447
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.64670079
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60039835
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.98753339
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85881655
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82860212
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82747956
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.64616379
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.40513335
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36653108
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27210075
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21160878
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20945046
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15114585
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06674160
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99234347
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95695551
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.94558011
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92498568
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81019615
21XRN2_22483619_ChIP-Seq_HELA_Human2.64487624
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54652032
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.49109352
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49017770
25VDR_23849224_ChIP-Seq_CD4+_Human2.45990051
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35554901
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34981056
28DCP1A_22483619_ChIP-Seq_HELA_Human2.32624091
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31291968
30* GABP_19822575_ChIP-Seq_HepG2_Human2.15836364
31FOXP3_21729870_ChIP-Seq_TREG_Human2.14171626
32TTF2_22483619_ChIP-Seq_HELA_Human2.13010535
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12931162
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.09767815
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.05721899
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99024958
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96151109
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94521057
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91833851
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.90441632
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84181758
42ELK1_19687146_ChIP-ChIP_HELA_Human1.78607147
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73887146
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69036051
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68814645
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67895936
47AR_21909140_ChIP-Seq_LNCAP_Human1.66323475
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65215005
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63257703
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55780843
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54331420
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51295859
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40561596
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.40443799
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40320396
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35947217
57CIITA_25753668_ChIP-Seq_RAJI_Human1.35748189
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.35718248
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.33097599
60ZNF263_19887448_ChIP-Seq_K562_Human1.31693297
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28894518
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28452760
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26632616
64MYC_18940864_ChIP-ChIP_HL60_Human1.24917066
65VDR_21846776_ChIP-Seq_THP-1_Human1.22645296
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21981525
67KDM5A_27292631_Chip-Seq_BREAST_Human1.21263572
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20442171
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16492169
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16398204
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15934985
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14224605
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13818040
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13593147
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12635753
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12501592
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11951505
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11671904
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09822919
80IRF1_19129219_ChIP-ChIP_H3396_Human1.08457375
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07325930
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05856831
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.04922417
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04591002
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01217909
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00927589
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99960742
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97155272
89* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95380149
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.95209764
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94859230
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.94761401
93* SPI1_23547873_ChIP-Seq_NB4_Human0.93370889
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.92409504
95MYC_22102868_ChIP-Seq_BL_Human0.91633419
96* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91293412
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90852253
98* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90304266
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89698274
100BCL6_27268052_Chip-Seq_Bcells_Human0.88485352
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88300680
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88155464
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87295634
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86770557
105* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86667765
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86569358
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.86300801
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85570103
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.85152329
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84954037
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84467040
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84299229
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83982946
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82007771
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80398212
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79709035
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.79628955
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78303644
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77950041
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76444289
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.76163115
122TFEB_21752829_ChIP-Seq_HELA_Human0.75540812
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.73732425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78796866
2MP0004957_abnormal_blastocyst_morpholog3.84141906
3MP0000372_irregular_coat_pigmentation3.47218299
4MP0003111_abnormal_nucleus_morphology3.42584447
5MP0010094_abnormal_chromosome_stability3.41188215
6MP0009379_abnormal_foot_pigmentation3.37321906
7MP0001529_abnormal_vocalization3.22851598
8MP0003077_abnormal_cell_cycle3.02200662
9MP0008058_abnormal_DNA_repair2.82206224
10MP0003123_paternal_imprinting2.80558072
11MP0008932_abnormal_embryonic_tissue2.79869354
12MP0009333_abnormal_splenocyte_physiolog2.76591905
13MP0003880_abnormal_central_pattern2.64411390
14MP0008057_abnormal_DNA_replication2.54304651
15MP0005075_abnormal_melanosome_morpholog2.41629743
16MP0005408_hypopigmentation2.33682887
17MP0002102_abnormal_ear_morphology2.33379257
18MP0003806_abnormal_nucleotide_metabolis2.30995607
19MP0005058_abnormal_lysosome_morphology2.24208700
20MP0001853_heart_inflammation2.01051433
21MP0003718_maternal_effect1.92649469
22MP0001764_abnormal_homeostasis1.92456408
23MP0008007_abnormal_cellular_replicative1.89336706
24MP0003315_abnormal_perineum_morphology1.88768903
25MP0001730_embryonic_growth_arrest1.82839321
26MP0006035_abnormal_mitochondrial_morpho1.80337061
27MP0004133_heterotaxia1.77163106
28MP0003786_premature_aging1.75771242
29MP0000015_abnormal_ear_pigmentation1.74087876
30MP0000537_abnormal_urethra_morphology1.72466306
31MP0000566_synostosis1.68598953
32MP0008877_abnormal_DNA_methylation1.66136311
33MP0009840_abnormal_foam_cell1.62714126
34MP0001905_abnormal_dopamine_level1.61755099
35MP0002653_abnormal_ependyma_morphology1.61552844
36MP0005671_abnormal_response_to1.57653744
37MP0003122_maternal_imprinting1.57629586
38MP0002160_abnormal_reproductive_system1.54364726
39MP0006036_abnormal_mitochondrial_physio1.53959391
40MP0002095_abnormal_skin_pigmentation1.53353660
41MP0005423_abnormal_somatic_nervous1.52289253
42MP0006276_abnormal_autonomic_nervous1.51678656
43MP0003121_genomic_imprinting1.50974497
44MP0005257_abnormal_intraocular_pressure1.50272854
45MP0000350_abnormal_cell_proliferation1.47907545
46MP0002751_abnormal_autonomic_nervous1.47584200
47MP0006292_abnormal_olfactory_placode1.46905649
48MP0002148_abnormal_hypersensitivity_rea1.42648477
49MP0010030_abnormal_orbit_morphology1.40620503
50MP0002938_white_spotting1.39649116
51MP0003119_abnormal_digestive_system1.36610890
52MP0008789_abnormal_olfactory_epithelium1.33783828
53MP0005451_abnormal_body_composition1.30902850
54MP0003938_abnormal_ear_development1.25126837
55MP0001188_hyperpigmentation1.25126078
56MP0002019_abnormal_tumor_incidence1.24172878
57MP0002638_abnormal_pupillary_reflex1.22563881
58MP0001697_abnormal_embryo_size1.20422064
59MP0003186_abnormal_redox_activity1.19466387
60MP0000358_abnormal_cell_content/1.19051839
61MP0005464_abnormal_platelet_physiology1.18886354
62MP0000049_abnormal_middle_ear1.18159990
63MP0009785_altered_susceptibility_to1.17574572
64MP0001727_abnormal_embryo_implantation1.17305643
65MP0005360_urolithiasis1.16978253
66MP0002080_prenatal_lethality1.14515493
67MP0003283_abnormal_digestive_organ1.11846322
68MP0003890_abnormal_embryonic-extraembry1.11799033
69MP0002085_abnormal_embryonic_tissue1.10534108
70MP0005389_reproductive_system_phenotype1.08652404
71MP0002210_abnormal_sex_determination1.07646704
72MP0000778_abnormal_nervous_system1.07403410
73MP0001485_abnormal_pinna_reflex1.05569718
74MP0001835_abnormal_antigen_presentation1.04410375
75MP0000343_altered_response_to1.04354458
76MP0005025_abnormal_response_to1.04104491
77MP0000371_diluted_coat_color1.03778798
78MP0003191_abnormal_cellular_cholesterol1.03311977
79MP0005499_abnormal_olfactory_system1.03128303
80MP0005394_taste/olfaction_phenotype1.03128303
81MP0002163_abnormal_gland_morphology1.02701422
82MP0002736_abnormal_nociception_after1.02112064
83MP0001293_anophthalmia1.01074694
84MP0003937_abnormal_limbs/digits/tail_de1.00346783
85MP0003436_decreased_susceptibility_to1.00027653
86MP0002429_abnormal_blood_cell0.99990166
87MP0002877_abnormal_melanocyte_morpholog0.99564053
88MP0001145_abnormal_male_reproductive0.97963517
89MP0000689_abnormal_spleen_morphology0.97222954
90MP0005171_absent_coat_pigmentation0.96919519
91MP0001661_extended_life_span0.95966603
92MP0001672_abnormal_embryogenesis/_devel0.95942871
93MP0005380_embryogenesis_phenotype0.95942871
94MP0002722_abnormal_immune_system0.95892393
95MP0001545_abnormal_hematopoietic_system0.95281544
96MP0005397_hematopoietic_system_phenotyp0.95281544
97MP0001819_abnormal_immune_cell0.94988627
98MP0002420_abnormal_adaptive_immunity0.94577250
99MP0003136_yellow_coat_color0.94190580
100MP0000858_altered_metastatic_potential0.93389545
101MP0000313_abnormal_cell_death0.93363650
102MP0003763_abnormal_thymus_physiology0.93336168
103MP0005165_increased_susceptibility_to0.93123827
104MP0002723_abnormal_immune_serum0.93035069
105MP0009053_abnormal_anal_canal0.92459195
106MP0003861_abnormal_nervous_system0.91872158
107MP0002398_abnormal_bone_marrow0.91722791
108MP0002452_abnormal_antigen_presenting0.91695900
109MP0006082_CNS_inflammation0.91592813
110MP0005000_abnormal_immune_tolerance0.91108238
111MP0005084_abnormal_gallbladder_morpholo0.90821274
112MP0008260_abnormal_autophagy0.90739668
113MP0000631_abnormal_neuroendocrine_gland0.90678595
114MP0002084_abnormal_developmental_patter0.90578941
115MP0002184_abnormal_innervation0.89578058
116MP0004142_abnormal_muscle_tone0.88463984
117MP0008469_abnormal_protein_level0.88097594
118MP0002734_abnormal_mechanical_nocicepti0.87759948
119MP0001881_abnormal_mammary_gland0.86141543
120MP0001929_abnormal_gametogenesis0.85330729
121MP0001968_abnormal_touch/_nociception0.84388970
122MP0001986_abnormal_taste_sensitivity0.83922965
123MP0005319_abnormal_enzyme/_coenzyme0.82915924
124MP0000716_abnormal_immune_system0.82841430
125MP0005330_cardiomyopathy0.82265840
126MP0005379_endocrine/exocrine_gland_phen0.81652546
127MP0001186_pigmentation_phenotype0.81502053
128MP0002419_abnormal_innate_immunity0.81458039
129MP0001845_abnormal_inflammatory_respons0.80981970
130MP0002396_abnormal_hematopoietic_system0.80225241
131MP0002405_respiratory_system_inflammati0.80221083
132MP0008875_abnormal_xenobiotic_pharmacok0.79961746
133MP0002254_reproductive_system_inflammat0.79346456
134MP0003075_altered_response_to0.79255274
135MP0004147_increased_porphyrin_level0.79110263
136MP0000685_abnormal_immune_system0.78201485
137MP0001324_abnormal_eye_pigmentation0.78065307
138MP0000653_abnormal_sex_gland0.77574640
139MP0001440_abnormal_grooming_behavior0.77420441
140MP0005501_abnormal_skin_physiology0.77254142
141MP0000462_abnormal_digestive_system0.75766093
142MP0002234_abnormal_pharynx_morphology0.75501421
143MP0002075_abnormal_coat/hair_pigmentati0.75456754
144MP0005332_abnormal_amino_acid0.75454598
145MP0003984_embryonic_growth_retardation0.75294864
146MP0006072_abnormal_retinal_apoptosis0.74377304
147MP0002272_abnormal_nervous_system0.74107770
148MP0000026_abnormal_inner_ear0.73732007
149MP0002132_abnormal_respiratory_system0.73304739
150MP0001286_abnormal_eye_development0.71464656
151MP0002088_abnormal_embryonic_growth/wei0.71299888
152MP0002752_abnormal_somatic_nervous0.69495468
153MP0003942_abnormal_urinary_system0.67784373
154MP0002152_abnormal_brain_morphology0.66808801
155MP0003698_abnormal_male_reproductive0.66628645
156MP0003567_abnormal_fetal_cardiomyocyte0.65831679
157MP0001984_abnormal_olfaction0.65639463
158MP0004924_abnormal_behavior0.64303780
159MP0005386_behavior/neurological_phenoty0.64303780
160MP0000490_abnormal_crypts_of0.64116834
161MP0002111_abnormal_tail_morphology0.62895190

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.40955715
2Abnormal mitochondria in muscle tissue (HP:0008316)4.89373433
3Mitochondrial inheritance (HP:0001427)4.59786592
4Progressive macrocephaly (HP:0004481)4.32289706
5Acute encephalopathy (HP:0006846)4.23793302
6Increased hepatocellular lipid droplets (HP:0006565)4.14393057
7Increased serum pyruvate (HP:0003542)4.13455174
8Abnormality of glycolysis (HP:0004366)4.13455174
9Increased CSF lactate (HP:0002490)4.10493749
10Abnormality of cells of the erythroid lineage (HP:0012130)4.09519910
11Birth length less than 3rd percentile (HP:0003561)3.99905273
12Cerebral hypomyelination (HP:0006808)3.87695714
13Abnormal number of erythroid precursors (HP:0012131)3.72727914
14Hepatocellular necrosis (HP:0001404)3.70591253
15Breast hypoplasia (HP:0003187)3.66222268
16Reticulocytopenia (HP:0001896)3.60407749
17Lipid accumulation in hepatocytes (HP:0006561)3.59315129
183-Methylglutaconic aciduria (HP:0003535)3.57889433
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.55966440
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34498104
21Increased serum lactate (HP:0002151)3.32019064
22Macrocytic anemia (HP:0001972)3.25277706
23Exercise intolerance (HP:0003546)3.13846537
24Hepatic necrosis (HP:0002605)3.09552748
25Renal Fanconi syndrome (HP:0001994)3.04694154
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00804387
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00804387
28Oral leukoplakia (HP:0002745)2.93221208
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92824038
30Abnormal protein N-linked glycosylation (HP:0012347)2.92824038
31Abnormal protein glycosylation (HP:0012346)2.92824038
32Abnormal glycosylation (HP:0012345)2.92824038
33Cerebral edema (HP:0002181)2.91065533
34Exertional dyspnea (HP:0002875)2.84051380
35Pancytopenia (HP:0001876)2.82236213
36Lactic acidosis (HP:0003128)2.80267650
37Reduced antithrombin III activity (HP:0001976)2.80080823
38Leukodystrophy (HP:0002415)2.78891319
39Increased intramyocellular lipid droplets (HP:0012240)2.73338261
40Hyperglycinemia (HP:0002154)2.69069803
41Respiratory failure (HP:0002878)2.63498629
42Patellar aplasia (HP:0006443)2.60488459
43Lethargy (HP:0001254)2.54941067
44Pallor (HP:0000980)2.52236772
45Microvesicular hepatic steatosis (HP:0001414)2.52081402
46Rough bone trabeculation (HP:0100670)2.51975666
47CNS hypomyelination (HP:0003429)2.51409984
48Aplasia/Hypoplasia of the patella (HP:0006498)2.49121295
49Cholecystitis (HP:0001082)2.44315099
50Abnormal gallbladder physiology (HP:0012438)2.44315099
51Respiratory difficulties (HP:0002880)2.39333621
52Postnatal microcephaly (HP:0005484)2.35049578
53Secondary amenorrhea (HP:0000869)2.33880570
54Optic disc pallor (HP:0000543)2.32766564
55CNS demyelination (HP:0007305)2.32423981
56Carpal bone hypoplasia (HP:0001498)2.32057989
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31628041
58Dicarboxylic aciduria (HP:0003215)2.31628041
59Emotional lability (HP:0000712)2.30373124
60Ragged-red muscle fibers (HP:0003200)2.28214644
61Spastic paraparesis (HP:0002313)2.24982345
62Opisthotonus (HP:0002179)2.21111225
63Abnormality of the anterior horn cell (HP:0006802)2.20096317
64Degeneration of anterior horn cells (HP:0002398)2.20096317
65Absent radius (HP:0003974)2.18905293
66Abnormality of alanine metabolism (HP:0010916)2.17389958
67Hyperalaninemia (HP:0003348)2.17389958
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17389958
69Abnormality of the labia minora (HP:0012880)2.15982859
7011 pairs of ribs (HP:0000878)2.15772126
71Absent forearm bone (HP:0003953)2.15755486
72Aplasia involving forearm bones (HP:0009822)2.15755486
73Delusions (HP:0000746)2.15657591
74Petechiae (HP:0000967)2.14995881
75Aplastic anemia (HP:0001915)2.12700684
76Increased muscle lipid content (HP:0009058)2.10730518
77Cerebral palsy (HP:0100021)2.10579815
78Methylmalonic aciduria (HP:0012120)2.07811779
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06959234
80Colon cancer (HP:0003003)2.06602791
81Nausea (HP:0002018)2.06416699
82Aplasia/hypoplasia of the uterus (HP:0008684)2.04773652
83Generalized aminoaciduria (HP:0002909)2.04112768
84Absent thumb (HP:0009777)2.03267396
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01783629
86Testicular atrophy (HP:0000029)2.01327298
87Triphalangeal thumb (HP:0001199)1.99309826
88Supernumerary spleens (HP:0009799)1.98877121
89Abnormal number of incisors (HP:0011064)1.97743291
90Horseshoe kidney (HP:0000085)1.96745175
91Unsteady gait (HP:0002317)1.95372010
92Trismus (HP:0000211)1.95170722
93Progressive external ophthalmoplegia (HP:0000590)1.94155315
94Abnormality of the umbilical cord (HP:0010881)1.94101011
95Muscle fiber atrophy (HP:0100295)1.94005303
96Abnormality of the heme biosynthetic pathway (HP:0010472)1.93239381
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90864085
98Increased IgM level (HP:0003496)1.90662976
99Type I transferrin isoform profile (HP:0003642)1.90507940
100Sparse eyelashes (HP:0000653)1.89853610
101Microretrognathia (HP:0000308)1.88519057
102Meckel diverticulum (HP:0002245)1.88279695
103Premature graying of hair (HP:0002216)1.88159671
104Progressive muscle weakness (HP:0003323)1.85241560
105Progressive microcephaly (HP:0000253)1.84057461
106Dysphonia (HP:0001618)1.83917640
107Thrombocytosis (HP:0001894)1.82990220
108Abnormality of serum amino acid levels (HP:0003112)1.82807890
109Abnormality of the preputium (HP:0100587)1.82411239
110Cleft eyelid (HP:0000625)1.80825627
111Facial cleft (HP:0002006)1.79178245
112Megaloblastic anemia (HP:0001889)1.78191008
113Neutropenia (HP:0001875)1.77733521
114Abnormality of the ileum (HP:0001549)1.75649847
115Hyperammonemia (HP:0001987)1.75225368
116Premature ovarian failure (HP:0008209)1.74894127
117Hepatosplenomegaly (HP:0001433)1.73737972
118Abnormal umbilical cord blood vessels (HP:0011403)1.73090380
119Single umbilical artery (HP:0001195)1.73090380
120Abnormality of the fetal cardiovascular system (HP:0010948)1.73090380
121Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72716989
122Cellular immunodeficiency (HP:0005374)1.72353213
123Prolonged neonatal jaundice (HP:0006579)1.72351894
124Medulloblastoma (HP:0002885)1.72260734
125Death in infancy (HP:0001522)1.72101163
126Abnormal trabecular bone morphology (HP:0100671)1.72017505
127Hypoplasia of the radius (HP:0002984)1.71219310
128Abnormality of liposaccharide metabolism (HP:0010968)1.70083729
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.70083729
130Abnormality of glycolipid metabolism (HP:0010969)1.70083729
131Hypoplastic pelvis (HP:0008839)1.69694631
132Abnormalities of placenta or umbilical cord (HP:0001194)1.69373915
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69209772
134Hypergonadotropic hypogonadism (HP:0000815)1.68953914
135Vomiting (HP:0002013)1.68859201
136Selective tooth agenesis (HP:0001592)1.67563197
137Abnormality of renal resorption (HP:0011038)1.67128923
138Multiple enchondromatosis (HP:0005701)1.66821377
139Hypokinesia (HP:0002375)1.66595630
140Amniotic constriction ring (HP:0009775)1.65601825
141Abnormality of placental membranes (HP:0011409)1.65601825
142Type 2 muscle fiber atrophy (HP:0003554)1.64978741
143Pancreatic cysts (HP:0001737)1.64943327
144Small intestinal stenosis (HP:0012848)1.64813862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.12476027
2VRK24.74116939
3STK164.41826078
4WEE13.98375173
5EIF2AK13.06495962
6CDC72.67341231
7SRPK12.55188884
8VRK12.52180840
9TESK22.49836894
10NME22.40434398
11EIF2AK32.29808055
12TSSK62.18592544
13MAP3K112.15195120
14DYRK31.93858955
15NME11.91106705
16PNCK1.90520176
17PDK21.89786647
18CCNB11.82587061
19NUAK11.73699330
20TLK11.69465130
21PLK41.69291724
22PLK31.58572523
23BRSK21.56380588
24PLK11.54701186
25AURKA1.54067863
26IRAK31.51948753
27LIMK11.48560665
28CASK1.46421267
29DYRK21.40978448
30ACVR1B1.40817249
31PASK1.39861292
32NEK11.36142302
33TTK1.34636263
34BCR1.34384870
35BRSK11.28557629
36PBK1.27391619
37TAOK21.25410703
38MAP4K21.20835967
39MKNK11.20574138
40ARAF1.17615642
41BRAF1.15935978
42NEK21.15785615
43AURKB1.14458591
44SMG11.08407155
45DAPK11.08159811
46MAP3K31.06076885
47BCKDK1.05210165
48CDK191.03723402
49TESK11.02528082
50MARK10.99387450
51TRIM280.98069694
52UHMK10.97593208
53EPHA20.96676690
54CDK70.91385669
55CHEK20.89784548
56CSNK1G30.89494073
57ERN10.89264155
58MST40.88976700
59PIM20.87732632
60CDK80.82471709
61LRRK20.80994567
62ATR0.79766759
63MAP3K120.76872363
64PAK10.76392354
65RPS6KB20.74003630
66CSNK2A20.73611406
67PRKCI0.72355547
68MAP4K10.70591025
69CDK180.69451405
70CHEK10.69163798
71CSNK2A10.68159944
72IKBKB0.67426875
73MAPK130.66352720
74MAPKAPK30.64733442
75CDK140.64726467
76STK100.64579992
77PAK40.64025454
78CDK150.63526299
79PLK20.62744500
80WNK30.62132280
81TBK10.61691587
82CDK11A0.59884965
83CSNK1G10.58481670
84MKNK20.57817673
85SCYL20.54158389
86MAP2K70.54020316
87TAF10.53588601
88LMTK20.52979150
89MINK10.52389660
90AKT30.51751985
91CDK40.50933020
92TXK0.50280897
93OXSR10.48825256
94EIF2AK20.48415652
95MAP2K30.47905180
96TNIK0.47364196
97MATK0.47257442
98CSNK1G20.46386384
99ZAK0.45687203
100CSNK1A1L0.44949210
101CDK20.44140367
102PRKCG0.44119430
103CDK10.43174096
104STK40.42346750
105KSR10.42035632
106KDR0.41711693
107GRK60.41693329
108ERBB40.39412116
109MST1R0.39258273
110DAPK30.39023670
111CSNK1E0.38939041
112MOS0.38685136
113ILK0.38368906
114IRAK40.38140263
115MARK30.36369974
116TYK20.36142054
117MAP3K40.35383271
118CAMK2B0.35101286
119TGFBR10.35015410
120GRK70.34856557
121ABL20.34650972
122PIM10.34558019
123SIK30.33624217
124RPS6KA50.32182453
125MAP3K80.31560615
126PDK30.29945159
127PDK40.29945159
128RAF10.29908494
129ATM0.29704674
130RPS6KA40.29467723
131MUSK0.28720876
132LYN0.28372532
133MAPKAPK20.27894645
134YES10.26468878
135GRK50.26418850
136MAPK110.25256689
137AKT20.25077348

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.95501346
2Ribosome_Homo sapiens_hsa030104.38295025
3DNA replication_Homo sapiens_hsa030303.93163741
4RNA polymerase_Homo sapiens_hsa030203.89393602
5Oxidative phosphorylation_Homo sapiens_hsa001903.50368750
6Mismatch repair_Homo sapiens_hsa034303.43401688
7Parkinsons disease_Homo sapiens_hsa050123.17494238
8Spliceosome_Homo sapiens_hsa030403.06460339
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86446706
10* Pyrimidine metabolism_Homo sapiens_hsa002402.65408741
11Nucleotide excision repair_Homo sapiens_hsa034202.55334493
12Huntingtons disease_Homo sapiens_hsa050162.51598491
13RNA transport_Homo sapiens_hsa030132.49064311
14Homologous recombination_Homo sapiens_hsa034402.26389826
15Base excision repair_Homo sapiens_hsa034102.25049753
16Alzheimers disease_Homo sapiens_hsa050102.14869973
17Protein export_Homo sapiens_hsa030602.06306109
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06205913
19Cell cycle_Homo sapiens_hsa041101.86782161
20Basal transcription factors_Homo sapiens_hsa030221.70509729
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65065378
22Fanconi anemia pathway_Homo sapiens_hsa034601.57578225
23* Purine metabolism_Homo sapiens_hsa002301.56347089
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52003204
25One carbon pool by folate_Homo sapiens_hsa006701.47976804
26RNA degradation_Homo sapiens_hsa030181.45155838
27Primary immunodeficiency_Homo sapiens_hsa053401.28893185
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25782221
29Non-homologous end-joining_Homo sapiens_hsa034501.23945556
30mRNA surveillance pathway_Homo sapiens_hsa030151.13583384
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11721882
32Cardiac muscle contraction_Homo sapiens_hsa042601.10988854
33Oocyte meiosis_Homo sapiens_hsa041141.06252814
34Vitamin B6 metabolism_Homo sapiens_hsa007501.05543321
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.02983442
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00495469
37Galactose metabolism_Homo sapiens_hsa000520.97996923
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94957726
39Epstein-Barr virus infection_Homo sapiens_hsa051690.90437466
40Systemic lupus erythematosus_Homo sapiens_hsa053220.89367650
41Folate biosynthesis_Homo sapiens_hsa007900.83977360
42Collecting duct acid secretion_Homo sapiens_hsa049660.83140977
43Glutathione metabolism_Homo sapiens_hsa004800.78529337
44Biosynthesis of amino acids_Homo sapiens_hsa012300.76890436
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76479398
46p53 signaling pathway_Homo sapiens_hsa041150.76108466
47Antigen processing and presentation_Homo sapiens_hsa046120.74616401
48Vibrio cholerae infection_Homo sapiens_hsa051100.74233798
49Propanoate metabolism_Homo sapiens_hsa006400.74121906
50Regulation of autophagy_Homo sapiens_hsa041400.72319183
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70867917
52Alcoholism_Homo sapiens_hsa050340.69707396
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68033957
54* Metabolic pathways_Homo sapiens_hsa011000.67955511
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66482863
56Carbon metabolism_Homo sapiens_hsa012000.65381704
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63743836
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62859641
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62323224
60Pentose phosphate pathway_Homo sapiens_hsa000300.61299398
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61149998
62Peroxisome_Homo sapiens_hsa041460.60313336
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60062440
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59916709
65Sulfur relay system_Homo sapiens_hsa041220.59749074
66Other glycan degradation_Homo sapiens_hsa005110.58539023
67Pyruvate metabolism_Homo sapiens_hsa006200.56844495
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53752186
69Shigellosis_Homo sapiens_hsa051310.53607737
70Fatty acid metabolism_Homo sapiens_hsa012120.53401441
71Autoimmune thyroid disease_Homo sapiens_hsa053200.49681344
72Lysosome_Homo sapiens_hsa041420.49614766
73Arginine and proline metabolism_Homo sapiens_hsa003300.48168658
74Asthma_Homo sapiens_hsa053100.47433675
75Allograft rejection_Homo sapiens_hsa053300.47305587
76Phenylalanine metabolism_Homo sapiens_hsa003600.46480372
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46126011
78N-Glycan biosynthesis_Homo sapiens_hsa005100.45834334
79Graft-versus-host disease_Homo sapiens_hsa053320.45097938
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44665159
81Rheumatoid arthritis_Homo sapiens_hsa053230.43010758
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42735651
83Hedgehog signaling pathway_Homo sapiens_hsa043400.42153889
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.40934109
85Herpes simplex infection_Homo sapiens_hsa051680.40519132
86Fructose and mannose metabolism_Homo sapiens_hsa000510.40169611
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34569472
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33179325
89* Drug metabolism - other enzymes_Homo sapiens_hsa009830.32883941
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31589993
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31232716
92Nicotine addiction_Homo sapiens_hsa050330.31160993
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.30805416
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30718459
95Viral carcinogenesis_Homo sapiens_hsa052030.30133535
96Fatty acid degradation_Homo sapiens_hsa000710.29021263
97Steroid biosynthesis_Homo sapiens_hsa001000.28843513
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28102511
99Basal cell carcinoma_Homo sapiens_hsa052170.26662469
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25706548
101Fatty acid elongation_Homo sapiens_hsa000620.25014153
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24806544
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24416299
104Synaptic vesicle cycle_Homo sapiens_hsa047210.24398978
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.23930823
106Phototransduction_Homo sapiens_hsa047440.23125165
107Viral myocarditis_Homo sapiens_hsa054160.23123335
108Salmonella infection_Homo sapiens_hsa051320.22888396
109Amphetamine addiction_Homo sapiens_hsa050310.17961666
110Arachidonic acid metabolism_Homo sapiens_hsa005900.15609200
111Selenocompound metabolism_Homo sapiens_hsa004500.12252522
112Sulfur metabolism_Homo sapiens_hsa009200.12226497
113Hippo signaling pathway_Homo sapiens_hsa043900.08222319
114Tyrosine metabolism_Homo sapiens_hsa003500.06525626
115Ether lipid metabolism_Homo sapiens_hsa005650.06385006
116Linoleic acid metabolism_Homo sapiens_hsa005910.05818772
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05461510
118Dopaminergic synapse_Homo sapiens_hsa047280.04738145
119Renin-angiotensin system_Homo sapiens_hsa046140.04609307
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.04330284
121Phagosome_Homo sapiens_hsa041450.04079868
122HTLV-I infection_Homo sapiens_hsa051660.03846892
123Taste transduction_Homo sapiens_hsa047420.03080294
124Serotonergic synapse_Homo sapiens_hsa047260.02950944
125Wnt signaling pathway_Homo sapiens_hsa043100.01416260
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.00712210
127Gap junction_Homo sapiens_hsa04540-0.0392996
128Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0322065
129Butanoate metabolism_Homo sapiens_hsa00650-0.0195881
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0060047

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