ITGB1BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.07658881
2fusion of sperm to egg plasma membrane (GO:0007342)4.91231540
3multicellular organism reproduction (GO:0032504)4.82248347
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47670216
5proteasome assembly (GO:0043248)4.32869961
6acrosome assembly (GO:0001675)4.26076016
7DNA deamination (GO:0045006)4.25000933
8male meiosis (GO:0007140)4.22800832
9axonemal dynein complex assembly (GO:0070286)4.12728866
10respiratory electron transport chain (GO:0022904)4.12285673
11sperm-egg recognition (GO:0035036)4.10681017
12protein maturation by protein folding (GO:0022417)4.07521248
13piRNA metabolic process (GO:0034587)4.03868047
14electron transport chain (GO:0022900)4.01099028
15cilium or flagellum-dependent cell motility (GO:0001539)3.96137118
16regulation of RIG-I signaling pathway (GO:0039535)3.87208186
17negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.86366173
18cell wall macromolecule catabolic process (GO:0016998)3.86257462
19cell wall macromolecule metabolic process (GO:0044036)3.86257462
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84296148
21ATP synthesis coupled proton transport (GO:0015986)3.84296148
22protein complex biogenesis (GO:0070271)3.78825609
23protein heterotetramerization (GO:0051290)3.77849603
24reproduction (GO:0000003)3.76319265
25binding of sperm to zona pellucida (GO:0007339)3.66926085
26regulation of cilium movement (GO:0003352)3.66744838
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61065554
28cell-cell recognition (GO:0009988)3.59929931
29plasma membrane fusion (GO:0045026)3.56286400
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.55740824
31NADH dehydrogenase complex assembly (GO:0010257)3.55740824
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55740824
33protein neddylation (GO:0045116)3.55322408
34epithelial cilium movement (GO:0003351)3.55133619
35maturation of 5.8S rRNA (GO:0000460)3.53278432
36chaperone-mediated protein transport (GO:0072321)3.51826215
37termination of RNA polymerase III transcription (GO:0006386)3.50847597
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.50847597
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47558291
40protein deneddylation (GO:0000338)3.45759578
417-methylguanosine mRNA capping (GO:0006370)3.45112139
42sequestering of actin monomers (GO:0042989)3.43419870
432-deoxyribonucleotide biosynthetic process (GO:0009265)3.42912437
44sperm motility (GO:0030317)3.40952093
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37944704
46synaptonemal complex organization (GO:0070193)3.37121193
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37005906
48synaptonemal complex assembly (GO:0007130)3.36686875
497-methylguanosine RNA capping (GO:0009452)3.36042696
50RNA capping (GO:0036260)3.36042696
51GTP biosynthetic process (GO:0006183)3.34811691
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32902148
53mitochondrial respiratory chain complex assembly (GO:0033108)3.32648405
54male meiosis I (GO:0007141)3.31422348
55rRNA modification (GO:0000154)3.29998416
56monoubiquitinated protein deubiquitination (GO:0035520)3.29377963
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.28860393
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27574543
59regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.26890570
60meiosis I (GO:0007127)3.22143840
61single fertilization (GO:0007338)3.22022493
62negative regulation of nitric-oxide synthase activity (GO:0051001)3.15925236
63mitotic metaphase plate congression (GO:0007080)3.15190119
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14122988
65response to gravity (GO:0009629)3.13313398
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13194645
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11082031
68synaptic vesicle maturation (GO:0016188)3.10386802
69protein targeting to mitochondrion (GO:0006626)3.10200404
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09746778
71oxidative phosphorylation (GO:0006119)3.09644571
72lipid particle organization (GO:0034389)3.09017205
73peroxisome fission (GO:0016559)3.07915960
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07215681
75negative regulation of ligase activity (GO:0051352)3.06983435
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06983435
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05239161
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05239161
79negative regulation of response to food (GO:0032096)3.04266555
80negative regulation of appetite (GO:0032099)3.04266555
81motile cilium assembly (GO:0044458)3.03331014
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02240521
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02240521
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02240521
85positive regulation of ligase activity (GO:0051351)2.99780549
86cilium movement (GO:0003341)2.99275779
87protein K6-linked ubiquitination (GO:0085020)2.98369261
88regulation of cellular amino acid metabolic process (GO:0006521)2.96557357
89type B pancreatic cell proliferation (GO:0044342)2.95821805
90protein-cofactor linkage (GO:0018065)2.95312632
91triglyceride catabolic process (GO:0019433)2.93526305
92lipopolysaccharide biosynthetic process (GO:0009103)2.92320371
93melanin biosynthetic process (GO:0042438)2.90904346
94spermatid development (GO:0007286)2.90772819
95respiratory chain complex IV assembly (GO:0008535)2.89116129
96microtubule severing (GO:0051013)2.88935470
97transcription elongation from RNA polymerase II promoter (GO:0006368)2.88494615
98guanosine-containing compound biosynthetic process (GO:1901070)2.88261206
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.86325397
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86325397
101establishment of protein localization to mitochondrion (GO:0072655)2.84124492
102negative regulation of calcium ion transmembrane transport (GO:1903170)2.83233827
103negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.83233827
104acrosome reaction (GO:0007340)2.82830288
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.82317791
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.82264650
107aggressive behavior (GO:0002118)2.81546806
108aerobic respiration (GO:0009060)2.81385999
109deoxyribonucleotide biosynthetic process (GO:0009263)2.81099586
110positive regulation of megakaryocyte differentiation (GO:0045654)2.79991498
111synaptic vesicle exocytosis (GO:0016079)2.79733912
112regulation of exit from mitosis (GO:0007096)2.79580438
113cullin deneddylation (GO:0010388)2.77774803
114regulation of ligase activity (GO:0051340)2.77179372
115protein localization to mitochondrion (GO:0070585)2.77028509
116CTP metabolic process (GO:0046036)2.76932743
117CTP biosynthetic process (GO:0006241)2.76932743
118regulation of histone phosphorylation (GO:0033127)2.75513064
119immunoglobulin mediated immune response (GO:0016064)2.74878067
120regulation of cellular amine metabolic process (GO:0033238)2.74326608
121positive regulation of mitochondrial fission (GO:0090141)2.74192930
122neutral lipid catabolic process (GO:0046461)2.74166844
123acylglycerol catabolic process (GO:0046464)2.74166844
124negative regulation of heart rate (GO:0010459)2.72934607
125extracellular fibril organization (GO:0043206)2.72787423
126positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72608761
127NADH metabolic process (GO:0006734)2.72408714
128meiotic nuclear division (GO:0007126)2.72238287
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69827910
130UTP biosynthetic process (GO:0006228)2.69606553
131rRNA methylation (GO:0031167)2.69061187
132platelet dense granule organization (GO:0060155)2.67652770
133amino acid salvage (GO:0043102)2.67574483
134L-methionine salvage (GO:0071267)2.67574483
135L-methionine biosynthetic process (GO:0071265)2.67574483
136DNA replication checkpoint (GO:0000076)2.67405857
137meiotic cell cycle (GO:0051321)2.67386711
138CENP-A containing nucleosome assembly (GO:0034080)2.66937688
139neutrophil activation involved in immune response (GO:0002283)2.63862711
140nucleoside diphosphate phosphorylation (GO:0006165)2.63296314
141negative regulation of cation channel activity (GO:2001258)2.60693893
142tricarboxylic acid cycle (GO:0006099)2.60006951
143mitochondrial calcium ion homeostasis (GO:0051560)2.59627084
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59023631
145nucleobase-containing small molecule interconversion (GO:0015949)2.58976214
146CDP-diacylglycerol biosynthetic process (GO:0016024)2.57998195
147secondary metabolite biosynthetic process (GO:0044550)2.57867829
148regulation of meiosis I (GO:0060631)2.57847923
149regulation of mononuclear cell migration (GO:0071675)2.57393727
150positive regulation of actin filament depolymerization (GO:0030836)2.57058775
151pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56857088
152regulation of mitochondrial translation (GO:0070129)2.56664672
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56001317
154cellular potassium ion homeostasis (GO:0030007)2.54854471
155negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.54828257
156positive regulation of granulocyte differentiation (GO:0030854)2.54566198
157spermatid nucleus differentiation (GO:0007289)2.54478916
158cytochrome complex assembly (GO:0017004)2.54369017
159establishment of chromosome localization (GO:0051303)2.53805843
160deoxyribose phosphate biosynthetic process (GO:0046385)2.52921822
161heart process (GO:0003015)2.52859240
162heart contraction (GO:0060047)2.52859240
163short-term memory (GO:0007614)2.48956249
164metallo-sulfur cluster assembly (GO:0031163)2.47060421
165iron-sulfur cluster assembly (GO:0016226)2.47060421
166base-excision repair, AP site formation (GO:0006285)2.45967039
167CDP-diacylglycerol metabolic process (GO:0046341)2.45288651
168nucleoside diphosphate biosynthetic process (GO:0009133)2.44816509
169response to dietary excess (GO:0002021)2.44492447
170regulation of cell communication by electrical coupling (GO:0010649)2.44277929
171layer formation in cerebral cortex (GO:0021819)2.44198710
172hydrogen ion transmembrane transport (GO:1902600)2.43862038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.91331510
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.74799288
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64968116
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60910632
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.50298793
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.46324021
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32501255
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.06667571
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.02804704
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.94929781
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.80873459
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.76047186
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66204949
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64649138
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.62256917
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42731467
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.38100303
18VDR_23849224_ChIP-Seq_CD4+_Human2.30238878
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29354003
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24016938
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23465563
22KAP1_22055183_ChIP-Seq_ESCs_Mouse2.22063684
23GBX2_23144817_ChIP-Seq_PC3_Human2.20494494
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19196565
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17033043
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.16105495
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12773842
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04755193
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03035590
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95474647
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.95149723
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88056195
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84001753
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81706202
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73400846
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68853023
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65250195
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.64112249
39* GABP_19822575_ChIP-Seq_HepG2_Human1.63016583
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62474390
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59315269
42SPI1_23547873_ChIP-Seq_NB4_Human1.58488058
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58451659
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57017077
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56652802
46ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50760637
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.50548007
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.49008645
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48507078
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48468363
51* FOXP3_21729870_ChIP-Seq_TREG_Human1.46438432
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45739297
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45667296
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45586309
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.44586556
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44504741
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43115839
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43069662
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42974682
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41516877
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34414149
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33705878
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33230639
64ELK1_19687146_ChIP-ChIP_HELA_Human1.32964460
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31909481
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31854866
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31510926
68XRN2_22483619_ChIP-Seq_HELA_Human1.30905860
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.28660927
70VDR_22108803_ChIP-Seq_LS180_Human1.28526040
71* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27426600
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26734315
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24537193
74MYC_18940864_ChIP-ChIP_HL60_Human1.24252709
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24207021
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22939932
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.22553823
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22159345
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.21976678
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20785864
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19287740
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19266795
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19155958
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18003341
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17729724
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17604097
87TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15929530
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15844414
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15308051
90TTF2_22483619_ChIP-Seq_HELA_Human1.13072100
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12224822
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11267255
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10164072
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10122341
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10074552
96E2F7_22180533_ChIP-Seq_HELA_Human1.09676638
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09066232
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.08914950
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08594824
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.08249930
101ZNF263_19887448_ChIP-Seq_K562_Human1.07205166
102MYB_26560356_Chip-Seq_TH2_Human1.06710436
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06559605
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06310778
105* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02045017
106EOMES_21245162_ChIP-Seq_HESCs_Human1.02036228
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00533010
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00458517
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00388037
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99179732
111CJUN_26792858_Chip-Seq_BT549_Human0.99169393
112GATA3_21867929_ChIP-Seq_CD8_Mouse0.98497556
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98478608
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97499756
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97499756
116EZH2_27304074_Chip-Seq_ESCs_Mouse0.97362351
117FUS_26573619_Chip-Seq_HEK293_Human0.96839667
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96377666
119MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95832819
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95378734
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94254824
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94169766
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93908367
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92325917
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92274148
126* ELK1_22589737_ChIP-Seq_MCF10A_Human0.92248277
127JUN_21703547_ChIP-Seq_K562_Human0.92145806
128EZH2_22144423_ChIP-Seq_EOC_Human0.92134066
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91726239
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90964225
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90834114
132AR_21909140_ChIP-Seq_LNCAP_Human0.90092970
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90030211
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89935905
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89670738
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89456220
137LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88622855
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88251169
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87786601
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87439421
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87211298
142THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86804300
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86296548
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86071842
145SA1_22415368_ChIP-Seq_MEFs_Mouse0.85783376
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84459058
147CTCF_26484167_Chip-Seq_Bcells_Mouse0.83913543
148TP53_18474530_ChIP-ChIP_U2OS_Human0.83854775
149TAF15_26573619_Chip-Seq_HEK293_Human0.83449091
150STAT1_17558387_ChIP-Seq_HELA_Human0.83318727
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83214017
152BRD4_25478319_ChIP-Seq_HGPS_Human0.82930180
153REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82299782
154REST_18959480_ChIP-ChIP_MESCs_Mouse0.79732348
155MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78079174
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77451520
157CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76889075
158WT1_19549856_ChIP-ChIP_CCG9911_Human0.75921896
159SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.75593157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.05262134
2MP0005410_abnormal_fertilization3.92297821
3MP0003693_abnormal_embryo_hatching3.53971181
4MP0005451_abnormal_body_composition3.35961065
5MP0009046_muscle_twitch3.14839298
6MP0003880_abnormal_central_pattern3.03733055
7MP0005623_abnormal_meninges_morphology2.86664836
8MP0009785_altered_susceptibility_to2.75933453
9MP0002102_abnormal_ear_morphology2.71805945
10MP0008438_abnormal_cutaneous_collagen2.63090032
11MP0004859_abnormal_synaptic_plasticity2.58278969
12MP0005671_abnormal_response_to2.41772119
13MP0001835_abnormal_antigen_presentation2.36343222
14MP0001929_abnormal_gametogenesis2.15799096
15MP0003763_abnormal_thymus_physiology2.12308970
16MP0002272_abnormal_nervous_system2.11707662
17MP0003186_abnormal_redox_activity2.10898829
18MP0006082_CNS_inflammation2.10268459
19MP0003718_maternal_effect2.08790854
20MP0003806_abnormal_nucleotide_metabolis2.03111371
21MP0004957_abnormal_blastocyst_morpholog2.02786920
22MP0006035_abnormal_mitochondrial_morpho2.00783793
23MP0005000_abnormal_immune_tolerance1.98147016
24MP0003724_increased_susceptibility_to1.85872788
25MP0002148_abnormal_hypersensitivity_rea1.83787710
26MP0010094_abnormal_chromosome_stability1.79509271
27MP0001529_abnormal_vocalization1.79226416
28MP0008260_abnormal_autophagy1.79056232
29MP0009333_abnormal_splenocyte_physiolog1.76664089
30MP0001968_abnormal_touch/_nociception1.75948322
31MP0005025_abnormal_response_to1.75920111
32MP0008877_abnormal_DNA_methylation1.75893545
33MP0002419_abnormal_innate_immunity1.74616618
34MP0000343_altered_response_to1.73947724
35MP0006276_abnormal_autonomic_nervous1.72553383
36MP0002723_abnormal_immune_serum1.72218356
37MP0003077_abnormal_cell_cycle1.71690146
38MP0000858_altered_metastatic_potential1.71188670
39MP0002210_abnormal_sex_determination1.70348664
40MP0002736_abnormal_nociception_after1.70059604
41MP0003111_abnormal_nucleus_morphology1.69249614
42MP0003698_abnormal_male_reproductive1.68989466
43MP0002420_abnormal_adaptive_immunity1.68157140
44MP0002452_abnormal_antigen_presenting1.67923271
45MP0001819_abnormal_immune_cell1.66703999
46MP0003635_abnormal_synaptic_transmissio1.65103420
47MP0010368_abnormal_lymphatic_system1.64932113
48MP0004270_analgesia1.62186504
49MP0004215_abnormal_myocardial_fiber1.59491042
50MP0008007_abnormal_cellular_replicative1.58725484
51MP0001800_abnormal_humoral_immune1.55055720
52MP0002398_abnormal_bone_marrow1.51958484
53MP0002653_abnormal_ependyma_morphology1.50484791
54MP0009745_abnormal_behavioral_response1.49220801
55MP0002064_seizures1.47420143
56MP0001440_abnormal_grooming_behavior1.45855323
57MP0002405_respiratory_system_inflammati1.45636359
58MP0005171_absent_coat_pigmentation1.43874384
59MP0002638_abnormal_pupillary_reflex1.43704794
60MP0002837_dystrophic_cardiac_calcinosis1.43489988
61MP0001851_eye_inflammation1.42667057
62MP0001879_abnormal_lymphatic_vessel1.42263381
63MP0005058_abnormal_lysosome_morphology1.41114508
64MP0000685_abnormal_immune_system1.40830423
65MP0005423_abnormal_somatic_nervous1.37519478
66MP0006054_spinal_hemorrhage1.36957362
67MP0004185_abnormal_adipocyte_glucose1.32819990
68MP0000716_abnormal_immune_system1.31596546
69MP0001970_abnormal_pain_threshold1.31459515
70MP0003221_abnormal_cardiomyocyte_apopto1.31389933
71MP0000653_abnormal_sex_gland1.31315356
72MP0001984_abnormal_olfaction1.30929704
73MP0002572_abnormal_emotion/affect_behav1.30773976
74MP0005503_abnormal_tendon_morphology1.30702926
75MP0002734_abnormal_mechanical_nocicepti1.30617622
76MP0005666_abnormal_adipose_tissue1.30534704
77MP0003436_decreased_susceptibility_to1.30409242
78MP0006036_abnormal_mitochondrial_physio1.29881891
79MP0001905_abnormal_dopamine_level1.29240527
80MP0005387_immune_system_phenotype1.29048098
81MP0001790_abnormal_immune_system1.29048098
82MP0002971_abnormal_brown_adipose1.28981918
83MP0003191_abnormal_cellular_cholesterol1.28374273
84MP0001145_abnormal_male_reproductive1.27999686
85MP0009780_abnormal_chondrocyte_physiolo1.24872863
86MP0000689_abnormal_spleen_morphology1.24565243
87MP0002006_tumorigenesis1.23943607
88MP0002063_abnormal_learning/memory/cond1.22623720
89MP0001486_abnormal_startle_reflex1.21935811
90MP0003011_delayed_dark_adaptation1.21021516
91MP0003279_aneurysm1.20477964
92MP0001119_abnormal_female_reproductive1.19324709
93MP0001545_abnormal_hematopoietic_system1.19053103
94MP0005397_hematopoietic_system_phenotyp1.19053103
95MP0005310_abnormal_salivary_gland1.18592504
96MP0004510_myositis1.17815467
97MP0000751_myopathy1.17348181
98MP0008932_abnormal_embryonic_tissue1.17215109
99MP0002067_abnormal_sensory_capabilities1.17136064
100MP0000013_abnormal_adipose_tissue1.16002096
101MP0002429_abnormal_blood_cell1.15650409
102MP0005551_abnormal_eye_electrophysiolog1.15080004
103MP0008058_abnormal_DNA_repair1.14367236
104MP0002161_abnormal_fertility/fecundity1.14089131
105MP0002735_abnormal_chemical_nociception1.13545375
106MP0008569_lethality_at_weaning1.13131833
107MP0005375_adipose_tissue_phenotype1.12527133
108MP0000003_abnormal_adipose_tissue1.11186446
109MP0002090_abnormal_vision1.10533450
110MP0002722_abnormal_immune_system1.09937080
111MP0001727_abnormal_embryo_implantation1.08137962
112MP0001845_abnormal_inflammatory_respons1.07463967
113MP0005275_abnormal_skin_tensile1.07203561
114MP0001958_emphysema1.04883776
115MP0004130_abnormal_muscle_cell1.04731514
116MP0005379_endocrine/exocrine_gland_phen1.04487853
117MP0009053_abnormal_anal_canal1.04390880
118MP0005165_increased_susceptibility_to1.03581581
119MP0003656_abnormal_erythrocyte_physiolo1.03330094
120MP0003786_premature_aging1.02858125
121MP0004924_abnormal_behavior1.02461406
122MP0005386_behavior/neurological_phenoty1.02461406
123MP0002295_abnormal_pulmonary_circulatio1.02158814
124MP0002163_abnormal_gland_morphology1.00106817
125MP0003448_altered_tumor_morphology0.99924104
126MP0003137_abnormal_impulse_conducting0.99653075
127MP0005084_abnormal_gallbladder_morpholo0.98282937
128MP0002876_abnormal_thyroid_physiology0.96544273
129MP0005595_abnormal_vascular_smooth0.96247614
130MP0002019_abnormal_tumor_incidence0.95850687
131MP0005670_abnormal_white_adipose0.95819332
132MP0000372_irregular_coat_pigmentation0.95416465
133MP0003950_abnormal_plasma_membrane0.95090179
134MP0004147_increased_porphyrin_level0.94283346
135MP0008469_abnormal_protein_level0.93964464
136MP0009697_abnormal_copulation0.93478126
137MP0008874_decreased_physiological_sensi0.93403728
138MP0004142_abnormal_muscle_tone0.93381944
139MP0003699_abnormal_female_reproductive0.93346462
140MP0010386_abnormal_urinary_bladder0.91700126
141MP0004036_abnormal_muscle_relaxation0.90964992
142MP0008789_abnormal_olfactory_epithelium0.90698618
143MP0002733_abnormal_thermal_nociception0.90428720
144MP0002970_abnormal_white_adipose0.90106645
145MP0003633_abnormal_nervous_system0.89544684
146MP0005395_other_phenotype0.88657564
147MP0002184_abnormal_innervation0.87917370
148MP0000358_abnormal_cell_content/0.87807303
149MP0001853_heart_inflammation0.87774371
150MP0005408_hypopigmentation0.86756497
151MP0000015_abnormal_ear_pigmentation0.86491460
152MP0005452_abnormal_adipose_tissue0.85719068
153MP0000490_abnormal_crypts_of0.83516059
154MP0001542_abnormal_bone_strength0.83352957
155MP0003123_paternal_imprinting0.83194157
156MP0003385_abnormal_body_wall0.82783284
157MP0002234_abnormal_pharynx_morphology0.82426794
158MP0003136_yellow_coat_color0.82189836
159MP0005464_abnormal_platelet_physiology0.81853508
160MP0002160_abnormal_reproductive_system0.81750445
161MP0008057_abnormal_DNA_replication0.81119868
162MP0004484_altered_response_of0.81092436
163MP0000639_abnormal_adrenal_gland0.80355005
164MP0000703_abnormal_thymus_morphology0.80246835
165MP0000230_abnormal_systemic_arterial0.80197912
166MP0002066_abnormal_motor_capabilities/c0.79025088
167MP0002972_abnormal_cardiac_muscle0.78302629
168MP0000750_abnormal_muscle_regeneration0.78229142
169MP0004811_abnormal_neuron_physiology0.77725619
170MP0005620_abnormal_muscle_contractility0.77155801
171MP0001533_abnormal_skeleton_physiology0.76739696
172MP0002132_abnormal_respiratory_system0.76218044
173MP0005535_abnormal_body_temperature0.75744220
174MP0002095_abnormal_skin_pigmentation0.75637106
175MP0005584_abnormal_enzyme/coenzyme_acti0.75212425
176MP0000759_abnormal_skeletal_muscle0.74537709
177MP0000749_muscle_degeneration0.73711009
178MP0008775_abnormal_heart_ventricle0.73432244
179MP0000313_abnormal_cell_death0.73108124
180MP0005389_reproductive_system_phenotype0.67912383
181MP0001919_abnormal_reproductive_system0.66151128

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.83793155
2Abnormal respiratory motile cilium physiology (HP:0012261)4.34966942
3Myokymia (HP:0002411)4.28525978
4Absent/shortened dynein arms (HP:0200106)3.87752497
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.87752497
6Action tremor (HP:0002345)3.85848909
7Rhinitis (HP:0012384)3.73281225
8Male infertility (HP:0003251)3.71783385
9Recurrent abscess formation (HP:0002722)3.44412230
10Abnormal ciliary motility (HP:0012262)3.35710831
11Abnormal respiratory motile cilium morphology (HP:0005938)3.35419422
12Abnormal respiratory epithelium morphology (HP:0012253)3.35419422
13Cerebral edema (HP:0002181)3.32223131
14Nasal polyposis (HP:0100582)3.28715963
15Exertional dyspnea (HP:0002875)3.23320999
16Birth length less than 3rd percentile (HP:0003561)3.23081169
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13661202
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13661202
19Metaphyseal dysplasia (HP:0100255)3.12853468
20Elevated erythrocyte sedimentation rate (HP:0003565)3.04626667
21Increased hepatocellular lipid droplets (HP:0006565)3.04470020
22Chronic bronchitis (HP:0004469)3.04401806
23Retrobulbar optic neuritis (HP:0100654)3.02269355
24Optic neuritis (HP:0100653)3.02269355
25Acute necrotizing encephalopathy (HP:0006965)3.02034575
26Renal Fanconi syndrome (HP:0001994)2.99108716
27Retinal dysplasia (HP:0007973)2.93394414
28Myositis (HP:0100614)2.91044697
29Focal motor seizures (HP:0011153)2.89295980
30Respiratory failure (HP:0002878)2.87500525
31Breast hypoplasia (HP:0003187)2.85981386
32Abnormality of the nasal mucosa (HP:0000433)2.83470996
33Bronchitis (HP:0012387)2.82189349
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77859221
35CNS demyelination (HP:0007305)2.75713081
36Infertility (HP:0000789)2.74641932
37Mitochondrial inheritance (HP:0001427)2.73144329
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73080720
39Abnormality of alanine metabolism (HP:0010916)2.73080720
40Hyperalaninemia (HP:0003348)2.73080720
41Reduced subcutaneous adipose tissue (HP:0003758)2.71745318
42Orchitis (HP:0100796)2.69619522
43Recurrent bacterial skin infections (HP:0005406)2.69330418
44Lipid accumulation in hepatocytes (HP:0006561)2.68216787
45Recurrent bronchitis (HP:0002837)2.67381044
46Secondary amenorrhea (HP:0000869)2.67277905
47Focal dystonia (HP:0004373)2.62590370
48Abnormal mitochondria in muscle tissue (HP:0008316)2.61764937
49Abnormal spermatogenesis (HP:0008669)2.59068496
503-Methylglutaconic aciduria (HP:0003535)2.58169662
51Type II lissencephaly (HP:0007260)2.56726369
52Increased IgM level (HP:0003496)2.56415421
53Delusions (HP:0000746)2.55303630
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54683977
55Opisthotonus (HP:0002179)2.54570554
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.53477936
57Increased serum lactate (HP:0002151)2.50615070
58Increased CSF lactate (HP:0002490)2.49305179
59Bronchiectasis (HP:0002110)2.46943850
60Atonic seizures (HP:0010819)2.45359981
61Recurrent gram-negative bacterial infections (HP:0005420)2.44153267
62Hepatocellular necrosis (HP:0001404)2.42467872
63Acute encephalopathy (HP:0006846)2.41556225
64Recurrent sinusitis (HP:0011108)2.39539158
65X-linked dominant inheritance (HP:0001423)2.38681659
66Delayed gross motor development (HP:0002194)2.37538949
67Leukodystrophy (HP:0002415)2.35296117
68Limb dystonia (HP:0002451)2.33839674
69Aplastic anemia (HP:0001915)2.31183294
70Autoimmune thrombocytopenia (HP:0001973)2.31126316
71Progressive macrocephaly (HP:0004481)2.30821059
72Emotional lability (HP:0000712)2.29121762
73Eczematoid dermatitis (HP:0000976)2.28129599
74Muscle fiber atrophy (HP:0100295)2.26891909
75Febrile seizures (HP:0002373)2.26392756
76Abnormal eating behavior (HP:0100738)2.24840185
77Multiple enchondromatosis (HP:0005701)2.24174210
78Axonal loss (HP:0003447)2.21121574
79Autoamputation (HP:0001218)2.20691330
80Personality changes (HP:0000751)2.20164256
81Craniofacial dystonia (HP:0012179)2.19642593
82Retinal atrophy (HP:0001105)2.19462160
83Abnormality of macrophages (HP:0004311)2.19008649
84Respiratory difficulties (HP:0002880)2.18969928
85Hepatic necrosis (HP:0002605)2.18681958
86Mutism (HP:0002300)2.16778922
87Pancreatic cysts (HP:0001737)2.16524830
88Abnormality of renal resorption (HP:0011038)2.16379863
89Polyphagia (HP:0002591)2.16081524
90Nausea (HP:0002018)2.15243436
91Increased intramyocellular lipid droplets (HP:0012240)2.14577714
92Type 2 muscle fiber atrophy (HP:0003554)2.14246075
93Cerebellar dysplasia (HP:0007033)2.10598259
94IgG deficiency (HP:0004315)2.09884820
95Increased muscle lipid content (HP:0009058)2.09539215
96Petechiae (HP:0000967)2.09036522
97Oligomenorrhea (HP:0000876)2.08613297
98Poor head control (HP:0002421)2.07383643
99Pancreatic fibrosis (HP:0100732)2.07024174
100Keratoconjunctivitis sicca (HP:0001097)2.06013853
101Optic disc pallor (HP:0000543)2.05907963
102Postural tremor (HP:0002174)2.05789879
103Cleft eyelid (HP:0000625)2.05646959
104Focal seizures (HP:0007359)2.04684107
105Exercise intolerance (HP:0003546)2.03746988
106Flat capital femoral epiphysis (HP:0003370)2.02740547
107Pulmonary fibrosis (HP:0002206)2.02135614
108Absence seizures (HP:0002121)2.01403429
109Chronic sinusitis (HP:0011109)1.98382837
110Amniotic constriction ring (HP:0009775)1.97387148
111Abnormality of placental membranes (HP:0011409)1.97387148
112Cerebral hypomyelination (HP:0006808)1.97037672
113Vertebral compression fractures (HP:0002953)1.96074207
114Type I transferrin isoform profile (HP:0003642)1.95185495
115Vacuolated lymphocytes (HP:0001922)1.94820301
116Pancytopenia (HP:0001876)1.94228927
117Horizontal nystagmus (HP:0000666)1.94131007
118Medial flaring of the eyebrow (HP:0010747)1.92237306
119Combined immunodeficiency (HP:0005387)1.92204212
120Stomatitis (HP:0010280)1.88602180
121CNS hypomyelination (HP:0003429)1.87705012
122Adrenal hypoplasia (HP:0000835)1.87172763
123Intention tremor (HP:0002080)1.86153679
124Recurrent skin infections (HP:0001581)1.84414479
125Delayed CNS myelination (HP:0002188)1.83808077
126Keratoconjunctivitis (HP:0001096)1.83422907
127Severe combined immunodeficiency (HP:0004430)1.83299236
128Premature ovarian failure (HP:0008209)1.83296236
129Chronic otitis media (HP:0000389)1.83258297
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82997807
131Abnormality of glycolysis (HP:0004366)1.82228806
132Increased serum pyruvate (HP:0003542)1.82228806
133Obstructive lung disease (HP:0006536)1.82210871
134Chronic obstructive pulmonary disease (HP:0006510)1.82210871
135Recurrent otitis media (HP:0000403)1.82076431
136Premature rupture of membranes (HP:0001788)1.81881693
137Protrusio acetabuli (HP:0003179)1.81851575
138Torticollis (HP:0000473)1.81687723
139Patellar aplasia (HP:0006443)1.81671388
140Generalized aminoaciduria (HP:0002909)1.81286774
141Mediastinal lymphadenopathy (HP:0100721)1.79842858
142Hepatosplenomegaly (HP:0001433)1.79764367
143Reduced antithrombin III activity (HP:0001976)1.77886500
144Upper limb muscle weakness (HP:0003484)1.77842460
145Abnormal protein glycosylation (HP:0012346)1.77434855
146Abnormal glycosylation (HP:0012345)1.77434855
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77434855
148Abnormal protein N-linked glycosylation (HP:0012347)1.77434855
149Capillary hemangiomas (HP:0005306)1.77247816
150Chronic mucocutaneous candidiasis (HP:0002728)1.77227274
151Recurrent cutaneous fungal infections (HP:0011370)1.77227274
152Microglossia (HP:0000171)1.77136953
153Lactic acidosis (HP:0003128)1.77017315
154Poor speech (HP:0002465)1.76840846
155Acanthosis nigricans (HP:0000956)1.76697363
156Patchy hypopigmentation of hair (HP:0011365)1.76387512
157Microretrognathia (HP:0000308)1.76171858
158Asymmetric septal hypertrophy (HP:0001670)1.75178551
159Tongue fasciculations (HP:0001308)1.75060782
160Lethargy (HP:0001254)1.74040976
161Hypokinesia (HP:0002375)1.72490179
162Epileptic encephalopathy (HP:0200134)1.71729332
163Choreoathetosis (HP:0001266)1.71162211
164Hyperlipoproteinemia (HP:0010980)1.69160178
165Gait imbalance (HP:0002141)1.67372164
166Dialeptic seizures (HP:0011146)1.64990100
167Brushfield spots (HP:0001088)1.63627716
168Supranuclear gaze palsy (HP:0000605)1.62385099
169Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60395859
170Sensory axonal neuropathy (HP:0003390)1.59112774
171Myotonia (HP:0002486)1.58223298
172Neoplasm of the peripheral nervous system (HP:0100007)1.57377091
173Gliosis (HP:0002171)1.55569853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.08208773
2ARAF2.95503517
3PLK42.81699521
4EIF2AK12.70734836
5PDK42.64033539
6PDK32.64033539
7BUB12.32419484
8WEE12.18692436
9NEK12.15272486
10BRAF2.12154340
11TESK22.09504413
12MINK12.06792294
13CDK81.99121651
14PAK61.98469026
15GRK51.98377996
16MAP3K131.97705226
17MAP3K61.95794994
18MUSK1.93139496
19IRAK31.91920752
20STK38L1.91423753
21CAMKK21.88320647
22ACVR1B1.86511904
23BMPR21.85688795
24MOS1.78643204
25KSR21.77956670
26CCNB11.77513582
27CSNK1G21.73329890
28RAF11.73222407
29WNK31.71812978
30PDK21.69892496
31TRIM281.69132059
32ABL21.66482935
33STK161.65780855
34CSNK1G31.65633210
35MAP4K11.65431748
36RIPK41.65198767
37BCR1.65040130
38PLK21.64146026
39TBK11.60784606
40EPHB21.58220863
41TXK1.57686279
42RIPK11.57318496
43TESK11.51793551
44EPHA41.51697511
45ZAP701.48706862
46DYRK21.44246268
47KDR1.43435776
48MAPKAPK31.43163966
49BCKDK1.42270432
50IKBKE1.39721922
51EIF2AK31.39168288
52LATS21.38596574
53MAP3K111.38255204
54PIM21.37340890
55VRK21.34887004
56MARK11.31904662
57IRAK41.31355374
58NEK91.28704355
59SIK31.25524722
60JAK31.25251113
61PTK2B1.23528081
62MAP4K21.22982691
63MAP3K121.21324066
64PRKD31.19248731
65TAOK11.18319175
66BRSK21.17392825
67ERBB31.17054043
68CSNK1A1L1.15187627
69DAPK11.14536483
70KIT1.11462556
71SCYL21.10845293
72TYK21.10512419
73TGFBR21.09698565
74CSNK1G11.08053120
75MST41.07651005
76NLK1.07619889
77TEC1.07467901
78BLK1.06312927
79TLK11.05240096
80ERBB41.03084058
81VRK11.00990907
82RPS6KA40.99952283
83BMPR1B0.97097957
84PRKCG0.95591060
85NTRK20.91363999
86CDK140.87694768
87MAP3K50.86972798
88PLK10.83794998
89PBK0.83614909
90NTRK30.83410342
91STK240.80031257
92TIE10.79874157
93NEK20.78425582
94CHEK20.78205197
95CAMK2G0.76622633
96CDC70.76292326
97CDK180.75664788
98PAK40.74054095
99PKN10.70366572
100BRSK10.70178918
101MAPK130.69821658
102MAPKAPK50.69456093
103CAMK2D0.67287260
104TTK0.67245740
105CDK150.66766657
106PINK10.66365222
107LMTK20.64890611
108DAPK30.64495062
109SRPK10.64416289
110* CAMK2A0.62848871
111CDK11A0.62101850
112CAMK2B0.60305278
113STK100.60276265
114PLK30.60008262
115CAMK10.58462687
116AURKA0.58393165
117CDK90.57414549
118IKBKB0.56613906
119CASK0.55351359
120SYK0.54854360
121ADRBK10.54603603
122MAP3K140.54253546
123PRKCE0.53284933
124IRAK10.53253585
125ILK0.53137678
126PAK10.52984448
127NUAK10.49884766
128ADRBK20.48773616
129FES0.47553616
130PAK20.46517082
131DDR20.46027081
132MARK30.45952496
133LIMK10.44790891
134EIF2AK20.43522817
135DYRK30.43427508
136CAMKK10.42979018
137MAP2K70.42697016
138LATS10.42234289
139LYN0.41540839
140CDK50.39901991
141MAPK110.39128914
142PTK20.38500989
143PHKG20.38153709
144PHKG10.38153709
145LCK0.38105373
146PAK30.37948358
147MYLK0.37943672
148ROCK10.37691909
149MAP3K40.37342776
150TNIK0.36523953
151NME10.36056464
152TRPM70.34547804
153STK30.34184436
154AURKB0.33344520
155DMPK0.32518411
156GRK70.31027895
157CSNK2A10.29400304
158PDK10.29072928
159KSR10.28203856
160RPS6KA50.26766970
161MAP3K10.26040199

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.17238318
2RNA polymerase_Homo sapiens_hsa030203.93253725
3Vitamin B6 metabolism_Homo sapiens_hsa007503.04968563
4Basal transcription factors_Homo sapiens_hsa030222.71736211
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60203550
6Fatty acid elongation_Homo sapiens_hsa000622.53201344
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37893948
8Protein export_Homo sapiens_hsa030602.35725984
9DNA replication_Homo sapiens_hsa030302.28585538
10Pyrimidine metabolism_Homo sapiens_hsa002402.18728115
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16698984
12Ribosome_Homo sapiens_hsa030102.13895923
13Pyruvate metabolism_Homo sapiens_hsa006202.03214910
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98671413
15Oxidative phosphorylation_Homo sapiens_hsa001901.97348362
16Huntingtons disease_Homo sapiens_hsa050161.93092014
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89908505
18Synaptic vesicle cycle_Homo sapiens_hsa047211.80237917
19Cell cycle_Homo sapiens_hsa041101.79040115
20Homologous recombination_Homo sapiens_hsa034401.76219350
21Nucleotide excision repair_Homo sapiens_hsa034201.74300786
22Propanoate metabolism_Homo sapiens_hsa006401.71472313
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71152517
24Primary immunodeficiency_Homo sapiens_hsa053401.67870822
25Graft-versus-host disease_Homo sapiens_hsa053321.67807957
26Parkinsons disease_Homo sapiens_hsa050121.65566974
27RNA degradation_Homo sapiens_hsa030181.64530788
28Nicotine addiction_Homo sapiens_hsa050331.55229203
29Mismatch repair_Homo sapiens_hsa034301.45814296
30Base excision repair_Homo sapiens_hsa034101.45784149
31RNA transport_Homo sapiens_hsa030131.44502322
32Purine metabolism_Homo sapiens_hsa002301.41505774
33GABAergic synapse_Homo sapiens_hsa047271.37545848
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35088649
35Other glycan degradation_Homo sapiens_hsa005111.31014631
36Vibrio cholerae infection_Homo sapiens_hsa051101.30114272
37Morphine addiction_Homo sapiens_hsa050321.29819034
38Shigellosis_Homo sapiens_hsa051311.28984792
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26797914
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25337386
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24166901
42Epstein-Barr virus infection_Homo sapiens_hsa051691.21848102
43Alzheimers disease_Homo sapiens_hsa050101.20459055
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16382770
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15621064
46Rheumatoid arthritis_Homo sapiens_hsa053231.14205843
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13910752
48p53 signaling pathway_Homo sapiens_hsa041151.13897239
49Leishmaniasis_Homo sapiens_hsa051401.12915635
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.12003330
51Pentose phosphate pathway_Homo sapiens_hsa000301.11823401
52Carbon metabolism_Homo sapiens_hsa012001.11687967
53Fanconi anemia pathway_Homo sapiens_hsa034601.11369811
54Herpes simplex infection_Homo sapiens_hsa051681.10179999
55Linoleic acid metabolism_Homo sapiens_hsa005911.09708578
56Sulfur metabolism_Homo sapiens_hsa009201.09009544
57Regulation of autophagy_Homo sapiens_hsa041401.06324668
58Measles_Homo sapiens_hsa051621.06031302
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05951688
60Peroxisome_Homo sapiens_hsa041461.05134532
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03899508
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03751534
63Antigen processing and presentation_Homo sapiens_hsa046121.03665741
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.02198671
65Glycerolipid metabolism_Homo sapiens_hsa005611.01532044
66Ether lipid metabolism_Homo sapiens_hsa005651.00159744
67Oocyte meiosis_Homo sapiens_hsa041140.98652629
68Malaria_Homo sapiens_hsa051440.98314273
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96320476
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94153093
71Allograft rejection_Homo sapiens_hsa053300.94027735
72Dopaminergic synapse_Homo sapiens_hsa047280.93938993
73Legionellosis_Homo sapiens_hsa051340.89780025
74Arachidonic acid metabolism_Homo sapiens_hsa005900.87584370
75beta-Alanine metabolism_Homo sapiens_hsa004100.87001897
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85188124
77Hematopoietic cell lineage_Homo sapiens_hsa046400.84097530
78Sphingolipid metabolism_Homo sapiens_hsa006000.79228231
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77655000
80Circadian entrainment_Homo sapiens_hsa047130.76782244
81Tuberculosis_Homo sapiens_hsa051520.76780206
82Glutamatergic synapse_Homo sapiens_hsa047240.76623189
83Non-homologous end-joining_Homo sapiens_hsa034500.76606226
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75171479
85B cell receptor signaling pathway_Homo sapiens_hsa046620.74946164
86Fatty acid metabolism_Homo sapiens_hsa012120.74945975
87Salmonella infection_Homo sapiens_hsa051320.74679498
88Spliceosome_Homo sapiens_hsa030400.74353706
89Folate biosynthesis_Homo sapiens_hsa007900.73918231
90N-Glycan biosynthesis_Homo sapiens_hsa005100.73877474
91Lysosome_Homo sapiens_hsa041420.73170157
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.72670177
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72536254
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71628841
95PPAR signaling pathway_Homo sapiens_hsa033200.69701300
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69493373
97Fatty acid degradation_Homo sapiens_hsa000710.68897716
98Hepatitis B_Homo sapiens_hsa051610.68696223
99Asthma_Homo sapiens_hsa053100.68687493
100Amphetamine addiction_Homo sapiens_hsa050310.68536700
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68154173
102Osteoclast differentiation_Homo sapiens_hsa043800.67870631
103Salivary secretion_Homo sapiens_hsa049700.67793241
104Biosynthesis of amino acids_Homo sapiens_hsa012300.65022948
105Phagosome_Homo sapiens_hsa041450.64659169
106T cell receptor signaling pathway_Homo sapiens_hsa046600.61656925
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60954262
108VEGF signaling pathway_Homo sapiens_hsa043700.60511241
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60252319
110Long-term potentiation_Homo sapiens_hsa047200.60092551
111Apoptosis_Homo sapiens_hsa042100.59328772
112Circadian rhythm_Homo sapiens_hsa047100.58911932
113Glutathione metabolism_Homo sapiens_hsa004800.58189026
114Nitrogen metabolism_Homo sapiens_hsa009100.58075174
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57984847
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57764994
117Cardiac muscle contraction_Homo sapiens_hsa042600.56381869
118Influenza A_Homo sapiens_hsa051640.54804434
119Autoimmune thyroid disease_Homo sapiens_hsa053200.54736392
120Long-term depression_Homo sapiens_hsa047300.54346240
121Tyrosine metabolism_Homo sapiens_hsa003500.54020537
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53217976
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51017635
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.50900105
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.50535020
126Collecting duct acid secretion_Homo sapiens_hsa049660.49817485
127Gastric acid secretion_Homo sapiens_hsa049710.49543266
128Phototransduction_Homo sapiens_hsa047440.49255161
129Type I diabetes mellitus_Homo sapiens_hsa049400.48730117
130Steroid biosynthesis_Homo sapiens_hsa001000.48702787
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47824115
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47411304
133Butanoate metabolism_Homo sapiens_hsa006500.47272825
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46904004
135TNF signaling pathway_Homo sapiens_hsa046680.46783023
136Fructose and mannose metabolism_Homo sapiens_hsa000510.46467464
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45418167
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.45407673
139Pertussis_Homo sapiens_hsa051330.44456844
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44351976
141Cocaine addiction_Homo sapiens_hsa050300.44210629
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43413386
143Renin secretion_Homo sapiens_hsa049240.42483020
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40592676
145Pancreatic cancer_Homo sapiens_hsa052120.38216351
146Serotonergic synapse_Homo sapiens_hsa047260.37196811
147Calcium signaling pathway_Homo sapiens_hsa040200.37024531
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35587459
149Toxoplasmosis_Homo sapiens_hsa051450.35489106
150Arginine and proline metabolism_Homo sapiens_hsa003300.34732082
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34709893
152Tryptophan metabolism_Homo sapiens_hsa003800.34541487
153Phenylalanine metabolism_Homo sapiens_hsa003600.34428006
154Oxytocin signaling pathway_Homo sapiens_hsa049210.32705296
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32345990
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32228312
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32205538
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.30084341
159Sulfur relay system_Homo sapiens_hsa041220.28876042
160Endocytosis_Homo sapiens_hsa041440.27922451
161Viral carcinogenesis_Homo sapiens_hsa052030.27127019
162HTLV-I infection_Homo sapiens_hsa051660.26514264
163Metabolic pathways_Homo sapiens_hsa011000.25337575
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24546877

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