ITGAV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.66652190
2positive regulation by symbiont of host defense response (GO:0052509)4.44475660
3modulation by symbiont of host defense response (GO:0052031)4.44475660
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44475660
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44475660
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.44475660
7modulation by symbiont of host immune response (GO:0052553)4.44475660
8wound healing, spreading of epidermal cells (GO:0035313)4.16898128
9desmosome organization (GO:0002934)3.49349703
10collagen fibril organization (GO:0030199)3.46617940
11negative regulation of chondrocyte differentiation (GO:0032331)3.46530196
12positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.46360904
13regulation of transforming growth factor beta2 production (GO:0032909)3.45908854
14chondrocyte proliferation (GO:0035988)3.43871789
15positive regulation of p38MAPK cascade (GO:1900745)3.43092454
16positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.42065183
17wound healing, spreading of cells (GO:0044319)3.32469443
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.31474999
19regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.25972299
20cellular response to vitamin D (GO:0071305)3.24099029
21substrate-dependent cell migration (GO:0006929)3.20921699
22regulation of membrane protein ectodomain proteolysis (GO:0051043)3.17085319
23epithelial cell-cell adhesion (GO:0090136)3.16350273
24cellular response to vitamin (GO:0071295)3.13863972
25* endodermal cell differentiation (GO:0035987)3.09182482
26* apoptotic cell clearance (GO:0043277)3.07551965
27glomerular visceral epithelial cell development (GO:0072015)3.04417858
28bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03965793
29neuron projection extension involved in neuron projection guidance (GO:1902284)2.99823571
30axon extension involved in axon guidance (GO:0048846)2.99823571
31skin morphogenesis (GO:0043589)2.99322930
32macrophage activation involved in immune response (GO:0002281)2.98847546
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.98141415
34regulation of interferon-beta biosynthetic process (GO:0045357)2.97268213
35protein localization to endosome (GO:0036010)2.94091285
36gap junction assembly (GO:0016264)2.91790872
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90931408
38negative regulation of fatty acid transport (GO:2000192)2.89965047
39platelet-derived growth factor receptor signaling pathway (GO:0048008)2.89370431
40positive regulation of endothelial cell apoptotic process (GO:2000353)2.88621855
41cellular response to interferon-alpha (GO:0035457)2.88186825
42regulation of cardioblast differentiation (GO:0051890)2.87111938
43I-kappaB phosphorylation (GO:0007252)2.86885235
44virion attachment to host cell (GO:0019062)2.86073270
45adhesion of symbiont to host cell (GO:0044650)2.86073270
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85290365
47response to host immune response (GO:0052572)2.85290365
48regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.81307454
49response to host (GO:0075136)2.77771358
50response to host defenses (GO:0052200)2.77771358
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77771358
52regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77499300
53positive regulation of macrophage cytokine production (GO:0060907)2.72322500
54regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69389806
55microglial cell activation (GO:0001774)2.65527701
56protein heterotrimerization (GO:0070208)2.64472980
57regulation of macrophage cytokine production (GO:0010935)2.63749777
58glomerular epithelial cell development (GO:0072310)2.62919292
59adherens junction assembly (GO:0034333)2.62379483
60response to lipoprotein particle (GO:0055094)2.62193910
61stress fiber assembly (GO:0043149)2.59616665
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59210869
63positive regulation of extracellular matrix organization (GO:1903055)2.58507890
64collagen metabolic process (GO:0032963)2.58479272
65protein hydroxylation (GO:0018126)2.57936220
66* substrate adhesion-dependent cell spreading (GO:0034446)2.57730041
67collagen catabolic process (GO:0030574)2.56644038
68mesodermal cell differentiation (GO:0048333)2.55158888
69vascular endothelial growth factor signaling pathway (GO:0038084)2.55094608
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52709434
71hemidesmosome assembly (GO:0031581)2.52612041
72COPII vesicle coating (GO:0048208)2.52386432
73protein retention in ER lumen (GO:0006621)2.52282532
74retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52038284
75cell-substrate adherens junction assembly (GO:0007045)2.51036387
76focal adhesion assembly (GO:0048041)2.51036387
77COPI coating of Golgi vesicle (GO:0048205)2.49984407
78Golgi transport vesicle coating (GO:0048200)2.49984407
79surfactant homeostasis (GO:0043129)2.49149806
80regulation of transforming growth factor beta1 production (GO:0032908)2.47977535
81regulation of extracellular matrix disassembly (GO:0010715)2.47931349
82renal filtration (GO:0097205)2.47682893
83pathway-restricted SMAD protein phosphorylation (GO:0060389)2.46337298
84* extracellular matrix organization (GO:0030198)2.45285847
85response to fluid shear stress (GO:0034405)2.44630625
86hypotonic response (GO:0006971)2.44536574
87lymphangiogenesis (GO:0001946)2.44388932
88* extracellular structure organization (GO:0043062)2.44254897
89positive regulation of cellular amide metabolic process (GO:0034250)2.44191999
90membrane protein ectodomain proteolysis (GO:0006509)2.43994164
91peptidyl-proline hydroxylation (GO:0019511)2.42433846
92multicellular organismal macromolecule metabolic process (GO:0044259)2.42338617
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41525645
94cortical actin cytoskeleton organization (GO:0030866)2.41145983
95barbed-end actin filament capping (GO:0051016)2.40909655
96growth hormone receptor signaling pathway (GO:0060396)2.38501355
97glomerular basement membrane development (GO:0032836)2.37932935
98positive regulation of receptor recycling (GO:0001921)2.37766532
99paraxial mesoderm development (GO:0048339)2.37488754
100mesenchymal-epithelial cell signaling (GO:0060638)2.37328463
101positive regulation of interferon-alpha production (GO:0032727)2.37207056
102negative regulation of cartilage development (GO:0061037)2.36519016
103multicellular organismal catabolic process (GO:0044243)2.35922881
104extracellular matrix disassembly (GO:0022617)2.34762801
105endothelial cell morphogenesis (GO:0001886)2.34162736
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33844578
107dermatan sulfate biosynthetic process (GO:0030208)2.32111982
108protein localization to cell surface (GO:0034394)2.31771821
109regulation of interferon-alpha production (GO:0032647)2.31039112
110chemical homeostasis within a tissue (GO:0048875)2.30289000
111adhesion of symbiont to host (GO:0044406)2.30185247
112response to peptidoglycan (GO:0032494)2.29687039
113multicellular organismal metabolic process (GO:0044236)2.29546156
114positive regulation of epithelial cell migration (GO:0010634)2.29423480
115smooth muscle tissue development (GO:0048745)2.28158452
116* cell-matrix adhesion (GO:0007160)2.27950251
117negative regulation of protein localization to plasma membrane (GO:1903077)2.27585600
118branching involved in salivary gland morphogenesis (GO:0060445)2.26796495
119extracellular fibril organization (GO:0043206)2.25988131
120sequestering of extracellular ligand from receptor (GO:0035581)2.25794700
121regulation of early endosome to late endosome transport (GO:2000641)2.25775794
122diterpenoid biosynthetic process (GO:0016102)2.25286939
123* cell-substrate adhesion (GO:0031589)2.25023021
124semaphorin-plexin signaling pathway (GO:0071526)2.24721333
125cell migration involved in sprouting angiogenesis (GO:0002042)2.24148319
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.23670328
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.23660772
128positive regulation of endothelial cell migration (GO:0010595)2.23581314
129negative regulation of anoikis (GO:2000811)2.23489971
130regulation of glomerular filtration (GO:0003093)2.23448440
131regulation of p38MAPK cascade (GO:1900744)2.23313567
132hippo signaling (GO:0035329)2.22715157
133cell junction assembly (GO:0034329)2.22053176
134plasma membrane repair (GO:0001778)2.21227386
135positive regulation of heat generation (GO:0031652)2.20839630
136ganglion development (GO:0061548)2.20183267
137keratan sulfate catabolic process (GO:0042340)2.20097672
138dermatan sulfate metabolic process (GO:0030205)2.19732325
139regulation of steroid hormone biosynthetic process (GO:0090030)2.19153767
140regulation of integrin activation (GO:0033623)2.18473956
141negative regulation of keratinocyte proliferation (GO:0010839)2.18373025
142positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.17319869
143response to laminar fluid shear stress (GO:0034616)2.17269426
144positive regulation of bone remodeling (GO:0046852)2.17103043
145positive regulation of bone resorption (GO:0045780)2.17103043
146cell-substrate junction assembly (GO:0007044)2.16635959
147iron ion import (GO:0097286)2.15725921
148cortical cytoskeleton organization (GO:0030865)2.14419438
149neutrophil activation involved in immune response (GO:0002283)2.12290150
150basement membrane organization (GO:0071711)2.11839373
151chondrocyte development (GO:0002063)2.11820666
152positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.11369538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.70460278
2* TRIM28_21343339_ChIP-Seq_HEK293_Human3.68349109
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32397381
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90995854
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53834015
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39792815
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25445077
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16591322
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.16042278
10* CJUN_26792858_Chip-Seq_BT549_Human2.10544762
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.09186367
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05691167
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.04708945
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.02536819
15NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.02056570
16NRF2_20460467_ChIP-Seq_MEFs_Mouse2.02056570
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01216264
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.97887093
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.95505587
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94972537
21CLOCK_20551151_ChIP-Seq_293T_Human1.91508733
22* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89664677
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89522746
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.89070402
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87295369
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86528067
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.85158032
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.81577950
29* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80561679
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76296437
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75206031
32BRD4_25478319_ChIP-Seq_HGPS_Human1.75023671
33* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74635282
34* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74635282
35* GATA2_21666600_ChIP-Seq_HMVEC_Human1.74524326
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.74371412
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.72366692
38TP53_16413492_ChIP-PET_HCT116_Human1.71281066
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66746553
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65731596
41* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61889994
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56200381
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.55763089
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55649409
45VDR_24787735_ChIP-Seq_THP-1_Human1.51407690
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49131018
47TP53_18474530_ChIP-ChIP_U2OS_Human1.48222785
48* SOX2_20726797_ChIP-Seq_SW620_Human1.46632734
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46129458
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44702121
51* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41458884
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39504367
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38262213
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37545157
55RXR_22108803_ChIP-Seq_LS180_Human1.36657536
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35862172
57* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33415709
58PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30771074
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28594395
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25590616
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.25517558
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.25364810
63AHR_22903824_ChIP-Seq_MCF-7_Human1.24008379
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23938611
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20952135
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20942880
67TP63_23658742_ChIP-Seq_EP156T_Human1.19455983
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.18625532
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16808757
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16663448
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15996671
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15328610
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14577310
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13467304
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13260310
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.11242914
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11187694
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.10742945
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09282164
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.08312376
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08210299
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07974681
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06463314
84ZNF263_19887448_ChIP-Seq_K562_Human1.04884930
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.04159399
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03641068
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01948518
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01161524
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00135189
90* ISL1_27105846_Chip-Seq_CPCs_Mouse1.00062756
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99129391
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98489626
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98227785
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98131959
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97882217
96RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97882217
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97355421
98KLF5_25053715_ChIP-Seq_YYC3_Human0.96339436
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96251206
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96208287
101GBX2_23144817_ChIP-Seq_PC3_Human0.95996757
102PU_27001747_Chip-Seq_BMDM_Mouse0.95762445
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95589212
104* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94593119
105FOXA2_19822575_ChIP-Seq_HepG2_Human0.93988996
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93503121
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93259100
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92847160
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92534671
110* AR_21909140_ChIP-Seq_LNCAP_Human0.92415953
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92341082
112* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92208970
113BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92076962
114* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91942991
115RUNX_20019798_ChIP-Seq_JUKART_Human0.91427905
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90938082
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90869489
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89336261
119AR_21572438_ChIP-Seq_LNCaP_Human0.89136517
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88306677
121SPI1_23127762_ChIP-Seq_K562_Human0.88077812
122* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87607718
123* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87607718
124RXR_22158963_ChIP-Seq_LIVER_Mouse0.86993212
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86870595
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86234102
127GATA4_25053715_ChIP-Seq_YYC3_Human0.86118592
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.85944261
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.85709184
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84222134
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84055741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.95523135
2MP0005275_abnormal_skin_tensile3.40114005
3MP0003705_abnormal_hypodermis_morpholog3.15103037
4MP0000569_abnormal_digit_pigmentation2.92783556
5MP0005503_abnormal_tendon_morphology2.79568753
6MP0001958_emphysema2.76856617
7MP0010368_abnormal_lymphatic_system2.75753226
8MP0003566_abnormal_cell_adhesion2.63366226
9MP0005257_abnormal_intraocular_pressure2.62498919
10MP0003279_aneurysm2.56695472
11MP0004272_abnormal_basement_membrane2.48225462
12MP0005623_abnormal_meninges_morphology2.40611441
13MP0003091_abnormal_cell_migration2.39950283
14MP0002877_abnormal_melanocyte_morpholog2.31736865
15MP0010352_gastrointestinal_tract_polyps2.24000610
16MP0009384_cardiac_valve_regurgitation2.23860715
17MP0005058_abnormal_lysosome_morphology2.20065706
18* MP0003300_gastrointestinal_ulcer2.10813291
19MP0005171_absent_coat_pigmentation2.02206961
20MP0003303_peritoneal_inflammation1.94723972
21MP0004084_abnormal_cardiac_muscle1.86786755
22MP0003045_fibrosis1.83932085
23MP0003172_abnormal_lysosome_physiology1.83795999
24MP0005023_abnormal_wound_healing1.83036548
25MP0006054_spinal_hemorrhage1.70045313
26MP0005076_abnormal_cell_differentiation1.69273588
27MP0002896_abnormal_bone_mineralization1.63198209
28MP0002060_abnormal_skin_morphology1.63086335
29MP0000733_abnormal_muscle_development1.62169694
30MP0001299_abnormal_eye_distance/1.60465472
31MP0005508_abnormal_skeleton_morphology1.56314870
32MP0002998_abnormal_bone_remodeling1.55122285
33MP0004233_abnormal_muscle_weight1.51220003
34MP0001533_abnormal_skeleton_physiology1.45316149
35MP0002295_abnormal_pulmonary_circulatio1.44507333
36MP0005409_darkened_coat_color1.42919707
37MP0002168_other_aberrant_phenotype1.41095610
38MP0000767_abnormal_smooth_muscle1.38846773
39MP0003283_abnormal_digestive_organ1.38807682
40MP0009278_abnormal_bone_marrow1.36338994
41MP0003448_altered_tumor_morphology1.33749515
42MP0003436_decreased_susceptibility_to1.33341495
43MP0003453_abnormal_keratinocyte_physiol1.33298158
44MP0000762_abnormal_tongue_morphology1.33265998
45MP0005390_skeleton_phenotype1.31347702
46MP0009780_abnormal_chondrocyte_physiolo1.31218599
47MP0004947_skin_inflammation1.24613197
48MP0000751_myopathy1.24283821
49MP0009840_abnormal_foam_cell1.24053901
50MP0004036_abnormal_muscle_relaxation1.20761259
51MP0003868_abnormal_feces_composition1.19796113
52MP0002254_reproductive_system_inflammat1.19530333
53MP0005165_increased_susceptibility_to1.18522970
54MP0003011_delayed_dark_adaptation1.18466882
55MP0003828_pulmonary_edema1.16426754
56MP0000462_abnormal_digestive_system1.16034843
57MP0000579_abnormal_nail_morphology1.13707053
58MP0001243_abnormal_dermal_layer1.11759423
59MP0005197_abnormal_uvea_morphology1.11003685
60MP0010234_abnormal_vibrissa_follicle1.10180638
61MP0006138_congestive_heart_failure1.09898475
62MP0010678_abnormal_skin_adnexa1.09542273
63MP0005595_abnormal_vascular_smooth1.05062492
64MP0005164_abnormal_response_to1.04444600
65MP0002115_abnormal_skeleton_extremities1.04017424
66MP0003191_abnormal_cellular_cholesterol1.03531129
67MP0004858_abnormal_nervous_system1.03176543
68MP0003795_abnormal_bone_structure1.02418480
69MP0002933_joint_inflammation1.00995030
70MP0000013_abnormal_adipose_tissue1.00607520
71MP0000428_abnormal_craniofacial_morphol1.00080057
72MP0000604_amyloidosis0.99132388
73MP0010030_abnormal_orbit_morphology0.97793276
74MP0000163_abnormal_cartilage_morphology0.97317626
75MP0003075_altered_response_to0.95123206
76* MP0002419_abnormal_innate_immunity0.94883703
77MP0001542_abnormal_bone_strength0.94818030
78MP0002108_abnormal_muscle_morphology0.94020903
79MP0000383_abnormal_hair_follicle0.93612003
80MP0010307_abnormal_tumor_latency0.93554677
81MP0006082_CNS_inflammation0.93200233
82MP0000537_abnormal_urethra_morphology0.93176484
83MP0002928_abnormal_bile_duct0.92626294
84MP0004134_abnormal_chest_morphology0.91773377
85MP0005193_abnormal_anterior_eye0.90954163
86MP0005408_hypopigmentation0.90540312
87MP0000858_altered_metastatic_potential0.90288091
88MP0002113_abnormal_skeleton_development0.89190104
89MP0002972_abnormal_cardiac_muscle0.88210050
90MP0000534_abnormal_ureter_morphology0.86838709
91MP0003950_abnormal_plasma_membrane0.85930184
92MP0008004_abnormal_stomach_pH0.85533154
93MP0000371_diluted_coat_color0.84052278
94MP0002166_altered_tumor_susceptibility0.83624360
95MP0008775_abnormal_heart_ventricle0.83179011
96MP0005167_abnormal_blood-brain_barrier0.81849845
97MP0009250_abnormal_appendicular_skeleto0.81567491
98MP0003690_abnormal_glial_cell0.81422843
99MP0005330_cardiomyopathy0.80671434
100MP0000343_altered_response_to0.80642537
101MP0004087_abnormal_muscle_fiber0.79284987
102MP0003941_abnormal_skin_development0.78603039
103MP0001879_abnormal_lymphatic_vessel0.77188552
104MP0004215_abnormal_myocardial_fiber0.75602298
105MP0003195_calcinosis0.75591411
106MP0003115_abnormal_respiratory_system0.75335735
107MP0000003_abnormal_adipose_tissue0.75285573
108MP0003329_amyloid_beta_deposits0.75072199
109MP0000467_abnormal_esophagus_morphology0.74929468
110MP0005187_abnormal_penis_morphology0.74224646
111MP0002006_tumorigenesis0.74208019
112MP0005248_abnormal_Harderian_gland0.74189663
113MP0000627_abnormal_mammary_gland0.74142538
114MP0005388_respiratory_system_phenotype0.73849232
115MP0002133_abnormal_respiratory_system0.73849232
116* MP0001915_intracranial_hemorrhage0.73550430
117* MP0000432_abnormal_head_morphology0.72251399
118MP0004484_altered_response_of0.71335511
119MP0002282_abnormal_trachea_morphology0.70806824
120MP0004510_myositis0.69571492
121MP0000749_muscle_degeneration0.69559170
122MP0002697_abnormal_eye_size0.69346741
123* MP0001614_abnormal_blood_vessel0.69284677
124MP0002796_impaired_skin_barrier0.68999719
125* MP0003935_abnormal_craniofacial_develop0.68982257
126MP0005620_abnormal_muscle_contractility0.68828362
127MP0001661_extended_life_span0.68551670
128MP0004185_abnormal_adipocyte_glucose0.68167564
129MP0001849_ear_inflammation0.67341236
130MP0001191_abnormal_skin_condition0.67097415
131MP0003634_abnormal_glial_cell0.66674508
132MP0000750_abnormal_muscle_regeneration0.66531601
133MP0003183_abnormal_peptide_metabolism0.66383164
134MP0000249_abnormal_blood_vessel0.66152525
135* MP0002128_abnormal_blood_circulation0.65882031
136MP0003385_abnormal_body_wall0.65801855
137MP0009053_abnormal_anal_canal0.65793014
138* MP0002925_abnormal_cardiovascular_devel0.65762062
139MP0000516_abnormal_urinary_system0.64035694

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.77977440
2Protrusio acetabuli (HP:0003179)4.63950910
3Aortic dissection (HP:0002647)3.93843917
4Cervical subluxation (HP:0003308)3.92232924
5Atrophic scars (HP:0001075)3.65545758
6Cerebral aneurysm (HP:0004944)3.61783496
7Shallow orbits (HP:0000586)3.48824013
8Aortic aneurysm (HP:0004942)3.44782508
9Peritonitis (HP:0002586)3.27805882
10Ankle contracture (HP:0006466)3.14424117
11Dilatation of the ascending aorta (HP:0005111)3.10075042
12Osteolytic defects of the hand bones (HP:0009699)3.04816267
13Osteolytic defects of the phalanges of the hand (HP:0009771)3.04816267
14Mitral stenosis (HP:0001718)2.97908864
15Vascular tortuosity (HP:0004948)2.90892405
16Soft skin (HP:0000977)2.90137417
17Mitral valve prolapse (HP:0001634)2.88655884
18Right ventricular cardiomyopathy (HP:0011663)2.84460528
19Arterial tortuosity (HP:0005116)2.80343315
20Fragile skin (HP:0001030)2.69125817
21Increased cerebral lipofuscin (HP:0011813)2.59435513
22Short nail (HP:0001799)2.55628405
23Wormian bones (HP:0002645)2.55375327
24Vertebral compression fractures (HP:0002953)2.54037226
25Spondylolisthesis (HP:0003302)2.50816454
26Hematochezia (HP:0002573)2.50613567
27Neurofibrillary tangles (HP:0002185)2.49600826
28Genu recurvatum (HP:0002816)2.45795719
29Blue sclerae (HP:0000592)2.42980905
30Bladder diverticulum (HP:0000015)2.37263127
31Absent frontal sinuses (HP:0002688)2.36672495
32Persistence of primary teeth (HP:0006335)2.32553865
33Cardiovascular calcification (HP:0011915)2.29973755
34Thin bony cortex (HP:0002753)2.29620302
35Mucopolysacchariduria (HP:0008155)2.28880240
36Urinary glycosaminoglycan excretion (HP:0003541)2.28880240
37Dysostosis multiplex (HP:0000943)2.28383222
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.27184991
39Broad metatarsal (HP:0001783)2.26357801
40Tibial bowing (HP:0002982)2.25691066
41Abnormality of dentin (HP:0010299)2.21530647
42Myocardial infarction (HP:0001658)2.21224358
43Ulnar bowing (HP:0003031)2.20232247
44Broad face (HP:0000283)2.17775164
45Subacute progressive viral hepatitis (HP:0006572)2.16633860
46Neonatal short-limb short stature (HP:0008921)2.15342212
47Thick nail (HP:0001805)2.12249925
48Abnormality of polysaccharide metabolism (HP:0011012)2.12243393
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12243393
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12243393
51Increased density of long bones (HP:0006392)2.12073604
52Aneurysm (HP:0002617)2.11059975
53Follicular hyperkeratosis (HP:0007502)2.09504165
54Spinal cord lesions (HP:0100561)2.09416921
55Syringomyelia (HP:0003396)2.09416921
56Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08717084
57Coxa vara (HP:0002812)2.05408257
58Radial bowing (HP:0002986)2.04836670
59Cerebral inclusion bodies (HP:0100314)2.04204709
60Hypoplasia of the iris (HP:0007676)2.02988299
61Femoral bowing (HP:0002980)2.02756241
62Aortic regurgitation (HP:0001659)2.01715347
63Abnormality of the distal phalanges of the toes (HP:0010182)2.01447662
64Turricephaly (HP:0000262)2.01195998
65Natal tooth (HP:0000695)2.01178197
66Abnormality of the nasal septum (HP:0000419)2.00970932
67Hyperextensible skin (HP:0000974)1.97706083
68Bilateral sensorineural hearing impairment (HP:0008619)1.97488448
69Asymmetric septal hypertrophy (HP:0001670)1.96974201
70Axonal loss (HP:0003447)1.96145206
71Alopecia of scalp (HP:0002293)1.95830819
72Vertebral arch anomaly (HP:0008438)1.95745898
73Flat acetabular roof (HP:0003180)1.94981178
74Cupped ribs (HP:0000887)1.94947644
75Spinal rigidity (HP:0003306)1.93511025
76Increased connective tissue (HP:0009025)1.92257539
77Scapular winging (HP:0003691)1.91210629
78Onycholysis (HP:0001806)1.89685266
79Abnormality of carpal bone ossification (HP:0006257)1.89219552
80Broad ribs (HP:0000885)1.89209986
81Abnormality of the frontal sinuses (HP:0002687)1.86298590
82Overgrowth (HP:0001548)1.85182167
83Ectopia lentis (HP:0001083)1.84128388
84Ankyloglossia (HP:0010296)1.83006073
85Ovoid vertebral bodies (HP:0003300)1.82008803
86Hyporeflexia of lower limbs (HP:0002600)1.81343433
87Abnormal ossification of hand bones (HP:0005921)1.80836642
88Joint laxity (HP:0001388)1.79365121
89Camptodactyly of toe (HP:0001836)1.79187354
90Abnormality of the odontoid process (HP:0003310)1.79166162
91Type 1 muscle fiber predominance (HP:0003803)1.78699096
92Ventricular tachycardia (HP:0004756)1.76618560
93Abnormality of oral frenula (HP:0000190)1.76146068
94Abnormal delivery (HP:0001787)1.75861301
95Bowing of the arm (HP:0006488)1.75333352
96Bowed forearm bones (HP:0003956)1.75333352
97Bell-shaped thorax (HP:0001591)1.75307520
98Striae distensae (HP:0001065)1.75112811
99Tetraparesis (HP:0002273)1.75077442
100Knee flexion contracture (HP:0006380)1.75011208
101Mildly elevated creatine phosphokinase (HP:0008180)1.74755320
102Vacuolated lymphocytes (HP:0001922)1.74485274
103Choroideremia (HP:0001139)1.73469265
104Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73193273
105Aplasia involving bones of the upper limbs (HP:0009823)1.73075715
106Aplasia of the phalanges of the hand (HP:0009802)1.73075715
107Aplasia involving bones of the extremities (HP:0009825)1.73075715
108Distal lower limb amyotrophy (HP:0008944)1.72836121
109Focal segmental glomerulosclerosis (HP:0000097)1.72426878
110Hypoplastic ischia (HP:0003175)1.71537665
111Submucous cleft hard palate (HP:0000176)1.71214276
112Wide anterior fontanel (HP:0000260)1.71181943
113Urethral obstruction (HP:0000796)1.71129685
114Back pain (HP:0003418)1.70681955
115Fused cervical vertebrae (HP:0002949)1.70513033
116Abnormality of the acetabulum (HP:0003170)1.70261333
117Buphthalmos (HP:0000557)1.70175535
118Infantile muscular hypotonia (HP:0008947)1.69888311
119Frequent falls (HP:0002359)1.69530185
120Distal upper limb amyotrophy (HP:0007149)1.69338240
121Upper limb amyotrophy (HP:0009129)1.69338240
122Bowel diverticulosis (HP:0005222)1.68994042
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68747880
124Advanced eruption of teeth (HP:0006288)1.68514523
125Asymmetry of the thorax (HP:0001555)1.68512943
126Pulmonic stenosis (HP:0001642)1.68382387
127Disproportionate tall stature (HP:0001519)1.68161989
128Limited hip movement (HP:0008800)1.68114200
129Esophageal varix (HP:0002040)1.67139760
130Mitral regurgitation (HP:0001653)1.66786994
131Hypoplasia of the odontoid process (HP:0003311)1.66662331
132Biconcave vertebral bodies (HP:0004586)1.66526712
133Increased variability in muscle fiber diameter (HP:0003557)1.65899950
134Hypopigmentation of the fundus (HP:0007894)1.65726269
135Vascular calcification (HP:0004934)1.64359114
136Elbow flexion contracture (HP:0002987)1.62068245
137Milia (HP:0001056)1.60697418
138Papillary thyroid carcinoma (HP:0002895)1.60316799
139Broad long bones (HP:0005622)1.59781901
140Wrist flexion contracture (HP:0001239)1.58991667
141Macroorchidism (HP:0000053)1.58771782
142Aortic valve stenosis (HP:0001650)1.58722650
143Osteoarthritis (HP:0002758)1.56738535
144Spinal cord compression (HP:0002176)1.56446225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.38157072
2DDR23.30071445
3LATS12.99067759
4RIPK12.83971761
5LATS22.81294323
6PDGFRA2.73124857
7MYLK2.61637629
8TRIB32.26522204
9FRK2.12881477
10TIE12.10978637
11EPHA22.05630309
12EPHB11.88409963
13MAP3K141.87592250
14PTK61.87015961
15BMX1.83593249
16MET1.78222013
17TGFBR21.78162830
18TRPM71.78155047
19STK241.72271866
20EPHA31.72203782
21SIK11.71115993
22JAK11.70387452
23STK31.65807531
24PTK21.60466666
25PDGFRB1.60050405
26PAK21.53255402
27ERN11.45707429
28IRAK31.45419575
29SCYL21.43236992
30CAMK1D1.40443670
31NEK91.37194551
32TBK11.35458788
33FER1.35273040
34MST1R1.35239224
35DMPK1.33623010
36NUAK11.27102255
37PIK3CA1.23938380
38LMTK21.23464604
39JAK31.22233126
40CAMK1G1.20638654
41MAP3K21.19701582
42MAP3K121.18552097
43TAOK31.16633178
44LIMK11.15533554
45INSRR1.14317582
46CHUK1.11746992
47FGFR31.09924375
48ICK1.08982164
49PAK31.08654351
50TYK21.07086686
51ROCK21.04885370
52STK381.03424460
53PKN21.03303068
54MAP3K31.00449294
55NTRK10.99100532
56LRRK20.99079199
57GSK3A0.97861507
58CDK60.94659739
59ERBB40.93698053
60PIK3CG0.93494716
61CDC42BPA0.92433290
62RPS6KA40.89262569
63PLK20.89246273
64STK100.84697237
65CDK120.84685085
66EEF2K0.84382325
67MTOR0.84053377
68ERBB30.83753163
69MOS0.83163289
70FLT30.82026795
71INSR0.81247531
72IKBKB0.80668141
73WNK10.79930611
74CAMKK20.76086805
75IKBKE0.74719167
76PRKCH0.73652318
77PAK40.73008302
78KSR20.71258892
79FGFR10.68603390
80HCK0.68118077
81AKT30.67035596
82FGR0.65609740
83DYRK1B0.65374797
84FGFR20.64318083
85PRKCE0.64161006
86ABL20.63572264
87CSK0.63215983
88KIT0.62419416
89MAP3K60.61803539
90IGF1R0.61148016
91EGFR0.61144229
92PRKG20.61076249
93ROCK10.59876825
94MAP3K90.59676563
95WNK40.59675011
96MARK30.59477478
97IRAK40.59259506
98MAP3K130.58862638
99ABL10.58771491
100PRKD10.57224247
101KSR10.56518560
102RPS6KA20.56214268
103RET0.56083073
104PRKD30.55664691
105ARAF0.54846321
106CAMK2G0.53852907
107FGFR40.53744288
108STK390.53429514
109HIPK20.52460364
110PRKAA20.51276734
111CAMK2D0.50703741
112JAK20.50210896
113EPHB20.49601481
114SGK30.49277539
115TGFBR10.48597963
116ILK0.47852666
117SRC0.47515951
118MAP2K10.46144085
119CAMKK10.45786090
120CAMK2B0.45328159
121PRKD20.44572057
122MELK0.43116891
123SGK10.42560219
124TESK10.41863437
125CSF1R0.41772852
126MAPK70.41658876
127STK38L0.41298431
128PTK2B0.41121578
129IRAK10.41116066
130MAPKAPK30.41030550
131PIM20.40962260
132NEK60.40300288
133PBK0.36777628
134PDPK10.32206891
135PAK60.32107402
136BCR0.29489348
137PDK20.28714446
138OBSCN0.28688076
139DAPK30.25947391
140TYRO30.24923264
141MAP3K10.24179744

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045122.31496218
2Malaria_Homo sapiens_hsa051442.04746706
3* Focal adhesion_Homo sapiens_hsa045101.94237431
4Amoebiasis_Homo sapiens_hsa051461.75966557
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75409884
6* Proteoglycans in cancer_Homo sapiens_hsa052051.70552923
7Lysosome_Homo sapiens_hsa041421.68730962
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.64598860
9Leishmaniasis_Homo sapiens_hsa051401.63757470
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56011624
11Complement and coagulation cascades_Homo sapiens_hsa046101.55462380
12TNF signaling pathway_Homo sapiens_hsa046681.53626877
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53062280
14* Small cell lung cancer_Homo sapiens_hsa052221.50655619
15Adherens junction_Homo sapiens_hsa045201.50247991
16Osteoclast differentiation_Homo sapiens_hsa043801.47732800
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44128009
18Chronic myeloid leukemia_Homo sapiens_hsa052201.41156913
19MicroRNAs in cancer_Homo sapiens_hsa052061.41038614
20Toxoplasmosis_Homo sapiens_hsa051451.39522044
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.30380366
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.29431345
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24438965
24Prion diseases_Homo sapiens_hsa050201.24265735
25Pertussis_Homo sapiens_hsa051331.20959354
26* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19680810
27Bladder cancer_Homo sapiens_hsa052191.19257126
28Pancreatic cancer_Homo sapiens_hsa052121.17842525
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16464470
30Rheumatoid arthritis_Homo sapiens_hsa053231.16048806
31Tuberculosis_Homo sapiens_hsa051521.15278746
32* Phagosome_Homo sapiens_hsa041451.15199704
33Shigellosis_Homo sapiens_hsa051311.14517333
34Prostate cancer_Homo sapiens_hsa052151.12802816
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.11175573
36Glioma_Homo sapiens_hsa052141.10481999
37Melanoma_Homo sapiens_hsa052181.09695040
38* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05924686
39Protein digestion and absorption_Homo sapiens_hsa049741.04950003
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04216199
41Salmonella infection_Homo sapiens_hsa051321.03874710
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03484954
43TGF-beta signaling pathway_Homo sapiens_hsa043501.01740850
44Nitrogen metabolism_Homo sapiens_hsa009101.01411741
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00785147
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00067522
47Renal cell carcinoma_Homo sapiens_hsa052110.98534768
48* Dilated cardiomyopathy_Homo sapiens_hsa054140.98213104
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97181942
50* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96928327
51* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95437178
52Staphylococcus aureus infection_Homo sapiens_hsa051500.94066256
53Other glycan degradation_Homo sapiens_hsa005110.92795972
54Legionellosis_Homo sapiens_hsa051340.91140223
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90674025
56Viral myocarditis_Homo sapiens_hsa054160.89587111
57Platelet activation_Homo sapiens_hsa046110.88847452
58Type II diabetes mellitus_Homo sapiens_hsa049300.87284157
59* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86950373
60Measles_Homo sapiens_hsa051620.86839530
61Apoptosis_Homo sapiens_hsa042100.86801173
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86647939
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86540470
64Dorso-ventral axis formation_Homo sapiens_hsa043200.84277883
65Hepatitis B_Homo sapiens_hsa051610.83651004
66mTOR signaling pathway_Homo sapiens_hsa041500.82221160
67Rap1 signaling pathway_Homo sapiens_hsa040150.81631224
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81484907
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80819466
70PPAR signaling pathway_Homo sapiens_hsa033200.80422089
71Phenylalanine metabolism_Homo sapiens_hsa003600.79124206
72Hippo signaling pathway_Homo sapiens_hsa043900.78941267
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.78715774
74Thyroid cancer_Homo sapiens_hsa052160.78521826
75Gap junction_Homo sapiens_hsa045400.78436744
76Axon guidance_Homo sapiens_hsa043600.77495009
77Inositol phosphate metabolism_Homo sapiens_hsa005620.77487225
78Vibrio cholerae infection_Homo sapiens_hsa051100.76606604
79Influenza A_Homo sapiens_hsa051640.76451666
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76240464
81Histidine metabolism_Homo sapiens_hsa003400.75837300
82Prolactin signaling pathway_Homo sapiens_hsa049170.75411708
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74790008
84Hepatitis C_Homo sapiens_hsa051600.74541786
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71284323
86Insulin resistance_Homo sapiens_hsa049310.70568119
87Endocytosis_Homo sapiens_hsa041440.70282296
88Sphingolipid metabolism_Homo sapiens_hsa006000.70105233
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69961637
90Chemokine signaling pathway_Homo sapiens_hsa040620.69765639
91Melanogenesis_Homo sapiens_hsa049160.67989843
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.67791461
93Mineral absorption_Homo sapiens_hsa049780.67351440
94B cell receptor signaling pathway_Homo sapiens_hsa046620.67347322
95Circadian rhythm_Homo sapiens_hsa047100.66591445
96Hematopoietic cell lineage_Homo sapiens_hsa046400.66499107
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66317627
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.66232428
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.65789226
100Bile secretion_Homo sapiens_hsa049760.64292070
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63462552
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63291045
103N-Glycan biosynthesis_Homo sapiens_hsa005100.61555079
104Basal cell carcinoma_Homo sapiens_hsa052170.61499083
105Fatty acid biosynthesis_Homo sapiens_hsa000610.61130713
106* Pathways in cancer_Homo sapiens_hsa052000.59706933
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.59589119
108Graft-versus-host disease_Homo sapiens_hsa053320.59396842
109Renin secretion_Homo sapiens_hsa049240.58849301
110Tight junction_Homo sapiens_hsa045300.58429432
111Endometrial cancer_Homo sapiens_hsa052130.58191696
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57603525
113ErbB signaling pathway_Homo sapiens_hsa040120.57541555
114HIF-1 signaling pathway_Homo sapiens_hsa040660.57529743
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57351689
116Tyrosine metabolism_Homo sapiens_hsa003500.57202425
117FoxO signaling pathway_Homo sapiens_hsa040680.56237602
118Galactose metabolism_Homo sapiens_hsa000520.56058208
119Insulin signaling pathway_Homo sapiens_hsa049100.55935247
120VEGF signaling pathway_Homo sapiens_hsa043700.55334508
121Ras signaling pathway_Homo sapiens_hsa040140.55286669
122Ovarian steroidogenesis_Homo sapiens_hsa049130.55085681
123Choline metabolism in cancer_Homo sapiens_hsa052310.54484324
124Renin-angiotensin system_Homo sapiens_hsa046140.54092001
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53879017
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53539050
127GnRH signaling pathway_Homo sapiens_hsa049120.53394212
128African trypanosomiasis_Homo sapiens_hsa051430.53165710
129p53 signaling pathway_Homo sapiens_hsa041150.52058353
130Thyroid hormone synthesis_Homo sapiens_hsa049180.50934776
131Estrogen signaling pathway_Homo sapiens_hsa049150.50889868
132Type I diabetes mellitus_Homo sapiens_hsa049400.49876367
133MAPK signaling pathway_Homo sapiens_hsa040100.49580419
134Allograft rejection_Homo sapiens_hsa053300.48844807
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48030510
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47461738
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47338444
138Wnt signaling pathway_Homo sapiens_hsa043100.45897027
139Sulfur metabolism_Homo sapiens_hsa009200.45648122
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.45041231

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