ITGAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.90006859
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.90006859
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.90006859
4modulation by symbiont of host immune response (GO:0052553)6.90006859
5positive regulation by symbiont of host defense response (GO:0052509)6.90006859
6modulation by symbiont of host defense response (GO:0052031)6.90006859
7regulation of interferon-beta biosynthetic process (GO:0045357)5.80762264
8macrophage activation involved in immune response (GO:0002281)5.46167871
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33046823
10neutrophil activation involved in immune response (GO:0002283)5.32889258
11respiratory burst (GO:0045730)5.21045241
12detection of other organism (GO:0098543)5.09621839
13response to peptidoglycan (GO:0032494)5.08572356
14production of molecular mediator involved in inflammatory response (GO:0002532)5.01601568
15regulation of B cell receptor signaling pathway (GO:0050855)4.98515186
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.85153667
17response to host immune response (GO:0052572)4.85153667
18microglial cell activation (GO:0001774)4.84784695
19detection of bacterium (GO:0016045)4.78829844
20negative regulation of cell killing (GO:0031342)4.66823180
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66823180
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.53691878
23response to host (GO:0075136)4.53691878
24response to host defenses (GO:0052200)4.53691878
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.51115136
26macrophage activation (GO:0042116)4.23082584
27leukocyte aggregation (GO:0070486)4.23057998
28positive regulation of interferon-alpha production (GO:0032727)4.22601042
29antigen processing and presentation of endogenous antigen (GO:0019883)4.18311301
30regulation of gamma-delta T cell activation (GO:0046643)4.15169180
31immunoglobulin mediated immune response (GO:0016064)4.01910432
32neutrophil activation (GO:0042119)4.00506845
33mannose metabolic process (GO:0006013)3.99584205
34regulation of interferon-alpha production (GO:0032647)3.99495608
35negative regulation of granulocyte differentiation (GO:0030853)3.99135316
36regulation of mast cell degranulation (GO:0043304)3.98644377
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97513582
38positive regulation of antigen processing and presentation (GO:0002579)3.94571999
39neutrophil mediated immunity (GO:0002446)3.93572925
40myeloid cell activation involved in immune response (GO:0002275)3.92881577
41granulocyte activation (GO:0036230)3.91866868
42positive regulation of mast cell activation (GO:0033005)3.90170713
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87802363
44detection of biotic stimulus (GO:0009595)3.87016028
45apoptotic cell clearance (GO:0043277)3.78182275
46regulation of mast cell activation involved in immune response (GO:0033006)3.77223736
47lipoxygenase pathway (GO:0019372)3.74837540
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.73231083
49negative regulation of interleukin-12 production (GO:0032695)3.72522768
50detection of molecule of bacterial origin (GO:0032490)3.71192493
51regulation of leukocyte degranulation (GO:0043300)3.70499768
52regulation of mast cell activation (GO:0033003)3.67724948
53response to muramyl dipeptide (GO:0032495)3.65416965
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61681035
55leukotriene metabolic process (GO:0006691)3.59358431
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59244596
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.58515652
58superoxide anion generation (GO:0042554)3.56926832
59regulation of gamma-delta T cell differentiation (GO:0045586)3.54287726
60regulation of integrin activation (GO:0033623)3.53595519
61response to fungus (GO:0009620)3.50907079
62germinal center formation (GO:0002467)3.50368217
63negative regulation of erythrocyte differentiation (GO:0045647)3.49657022
64positive regulation of mast cell activation involved in immune response (GO:0033008)3.48462020
65positive regulation of mast cell degranulation (GO:0043306)3.48462020
66hydrogen peroxide biosynthetic process (GO:0050665)3.46663291
67negative regulation of T cell mediated immunity (GO:0002710)3.43882991
68negative regulation of leukocyte mediated immunity (GO:0002704)3.41202784
69regulation of apoptotic cell clearance (GO:2000425)3.40961845
70negative regulation of interleukin-6 production (GO:0032715)3.39894486
71positive regulation of gamma-delta T cell activation (GO:0046645)3.39755774
72regulation of antigen processing and presentation (GO:0002577)3.35518080
73positive regulation of cellular amide metabolic process (GO:0034250)3.33762533
74regulation of mononuclear cell migration (GO:0071675)3.29681544
75positive regulation of chemokine secretion (GO:0090197)3.29073489
76* neutrophil chemotaxis (GO:0030593)3.28727820
77positive regulation of B cell differentiation (GO:0045579)3.27325933
78pinocytosis (GO:0006907)3.26707737
79regulation of macrophage chemotaxis (GO:0010758)3.24687403
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21410258
81I-kappaB phosphorylation (GO:0007252)3.19475158
82* neutrophil migration (GO:1990266)3.18895159
83regulation of T-helper 2 cell differentiation (GO:0045628)3.18777347
84regulation of phagocytosis (GO:0050764)3.17541053
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16830255
86leukocyte degranulation (GO:0043299)3.15324875
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14998765
88positive regulation of leukocyte degranulation (GO:0043302)3.12450530
89reactive oxygen species biosynthetic process (GO:1903409)3.09933623
90regulation of interleukin-8 biosynthetic process (GO:0045414)3.09108152
91regulation of regulated secretory pathway (GO:1903305)3.04719117
92regulation of tolerance induction (GO:0002643)3.01683709
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01500690
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01147427
95myeloid leukocyte activation (GO:0002274)3.00255960
96interferon-gamma-mediated signaling pathway (GO:0060333)2.97928818
97defense response to protozoan (GO:0042832)2.96169908
98regulation of T cell tolerance induction (GO:0002664)2.94341761
99B cell receptor signaling pathway (GO:0050853)2.94276316
100positive thymic T cell selection (GO:0045059)2.91932507
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90764356
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.90648642
103positive regulation of interferon-beta production (GO:0032728)2.89549521
104defense response to fungus (GO:0050832)2.89258695
105negative thymic T cell selection (GO:0045060)2.88451798
106myeloid leukocyte mediated immunity (GO:0002444)2.87134429
107* cellular extravasation (GO:0045123)2.86138341
108antigen processing and presentation via MHC class Ib (GO:0002475)2.85712975
109* leukocyte cell-cell adhesion (GO:0007159)2.85396420
110response to protozoan (GO:0001562)2.85050081
111regulation of B cell differentiation (GO:0045577)2.84338724
112positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83863895
113negative regulation of type 2 immune response (GO:0002829)2.83723924
114positive regulation of regulated secretory pathway (GO:1903307)2.82326420
115negative regulation of cytokine production involved in immune response (GO:0002719)2.82196890
116* granulocyte chemotaxis (GO:0071621)2.81724333
117T-helper 1 type immune response (GO:0042088)2.81232043
118positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81026164
119B cell mediated immunity (GO:0019724)2.79618625
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79583329
121negative regulation of mast cell activation (GO:0033004)2.78680190
122regulation of interleukin-6 biosynthetic process (GO:0045408)2.78056059
123phagosome maturation (GO:0090382)2.77747113
124detection of external biotic stimulus (GO:0098581)2.77270722
125response to interleukin-15 (GO:0070672)2.75964941
126cellular defense response (GO:0006968)2.75928110
127macrophage differentiation (GO:0030225)2.75583853
128* granulocyte migration (GO:0097530)2.75052797
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72855569
130negative T cell selection (GO:0043383)2.72748931
131negative regulation of innate immune response (GO:0045824)2.72637565
132* leukocyte migration involved in inflammatory response (GO:0002523)2.72135513
133positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72087532
134leukocyte mediated cytotoxicity (GO:0001909)2.71799543
135lymphocyte chemotaxis (GO:0048247)2.70683532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.53234292
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.52680480
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.82801841
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.65263874
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.40157471
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90431422
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.84769593
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.68486538
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.65663014
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.25458363
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18572010
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06074972
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.04811640
14BRD4_27068464_Chip-Seq_AML-cells_Mouse2.73086286
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55919039
16SCL_19346495_ChIP-Seq_HPC-7_Human2.52240138
17* SPI1_23547873_ChIP-Seq_NB4_Human2.48166994
18SPI1_23127762_ChIP-Seq_K562_Human2.47793630
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46456357
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44869734
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38932202
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20555629
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20446594
24VDR_21846776_ChIP-Seq_THP-1_Human2.18993857
25VDR_24763502_ChIP-Seq_THP-1_Human2.13687942
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08548455
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.06299297
28RUNX_20019798_ChIP-Seq_JUKART_Human2.03295265
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.99806664
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97946122
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97725800
32PU_27001747_Chip-Seq_BMDM_Mouse1.90110994
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81652305
34* VDR_24787735_ChIP-Seq_THP-1_Human1.80706378
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79880682
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78105531
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74550756
38* MYB_26560356_Chip-Seq_TH2_Human1.72776611
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67826777
40GATA1_22025678_ChIP-Seq_K562_Human1.65144493
41MAF_26560356_Chip-Seq_TH1_Human1.64094698
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63151314
43TCF7_22412390_ChIP-Seq_EML_Mouse1.60516741
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59570962
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59221984
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53215955
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52986181
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49248779
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47214976
50MYB_26560356_Chip-Seq_TH1_Human1.42102805
51UTX_26944678_Chip-Seq_JUKART_Human1.40078758
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.33960110
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33407450
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30892865
55MYC_22102868_ChIP-Seq_BL_Human1.30315855
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28495238
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27407691
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26666753
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.25753844
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.24164641
61GATA3_27048872_Chip-Seq_THYMUS_Human1.23465954
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17436593
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16366909
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14730019
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14415141
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.13298292
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12755290
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12142326
69KDM2B_26808549_Chip-Seq_DND41_Human1.10117800
70GATA2_19941826_ChIP-Seq_K562_Human1.09312279
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06626825
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06292303
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05812709
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03983293
75* GATA3_26560356_Chip-Seq_TH2_Human1.03856318
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02788137
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02108747
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99985445
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99659471
80GATA1_19941826_ChIP-Seq_K562_Human0.98032936
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97508863
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97445161
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95738650
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95330076
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95116610
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94849801
87LXR_22292898_ChIP-Seq_THP-1_Human0.91469981
88* SPI1_20517297_ChIP-Seq_HL60_Human0.91416790
89BCL6_27268052_Chip-Seq_Bcells_Human0.89276971
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86814045
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86139938
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86130484
93BCOR_27268052_Chip-Seq_Bcells_Human0.85586009
94* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85233139
95MAF_26560356_Chip-Seq_TH2_Human0.85174642
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82546441
97EGR1_19032775_ChIP-ChIP_M12_Human0.82020326
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78270453
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77083840
100KDM2B_26808549_Chip-Seq_K562_Human0.76213734
101FOXM1_23109430_ChIP-Seq_U2OS_Human0.75263197
102SMRT_27268052_Chip-Seq_Bcells_Human0.68596035
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68482171
104TFEB_21752829_ChIP-Seq_HELA_Human0.66765735
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.66495325
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62628109
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62582406
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61644217
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.61110541
110* NCOR1_26117541_ChIP-Seq_K562_Human0.61013646
111P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60702472
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.57611678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.41050649
2MP0003436_decreased_susceptibility_to4.20371568
3MP0005058_abnormal_lysosome_morphology4.14753732
4MP0001835_abnormal_antigen_presentation3.57766674
5* MP0002419_abnormal_innate_immunity3.40969342
6MP0006082_CNS_inflammation3.08442224
7MP0003172_abnormal_lysosome_physiology3.00720502
8MP0005000_abnormal_immune_tolerance2.84922263
9MP0002148_abnormal_hypersensitivity_rea2.77551105
10MP0005464_abnormal_platelet_physiology2.72440702
11* MP0005025_abnormal_response_to2.70611145
12MP0001790_abnormal_immune_system2.61042681
13MP0005387_immune_system_phenotype2.61042681
14MP0009785_altered_susceptibility_to2.59184718
15MP0001533_abnormal_skeleton_physiology2.54022944
16* MP0002452_abnormal_antigen_presenting2.53099254
17MP0003724_increased_susceptibility_to2.50550348
18MP0003183_abnormal_peptide_metabolism2.43016705
19MP0003191_abnormal_cellular_cholesterol2.41305445
20MP0001800_abnormal_humoral_immune2.41002274
21MP0000569_abnormal_digit_pigmentation2.32228651
22MP0000685_abnormal_immune_system2.28816912
23MP0002723_abnormal_immune_serum2.24579632
24* MP0001819_abnormal_immune_cell2.16108504
25* MP0002420_abnormal_adaptive_immunity2.15435042
26MP0009278_abnormal_bone_marrow2.14336889
27MP0005671_abnormal_response_to2.11592554
28MP0003300_gastrointestinal_ulcer2.04408551
29MP0004510_myositis1.96956695
30MP0001851_eye_inflammation1.95390131
31MP0002405_respiratory_system_inflammati1.95363249
32MP0009840_abnormal_foam_cell1.90884260
33MP0000343_altered_response_to1.90220952
34MP0004947_skin_inflammation1.87512446
35* MP0001845_abnormal_inflammatory_respons1.79481422
36MP0003690_abnormal_glial_cell1.77614244
37MP0005451_abnormal_body_composition1.75587521
38* MP0003075_altered_response_to1.62448897
39MP0001853_heart_inflammation1.60187985
40MP0003448_altered_tumor_morphology1.57650711
41* MP0000716_abnormal_immune_system1.57472192
42MP0000604_amyloidosis1.54686881
43MP0003763_abnormal_thymus_physiology1.53810319
44MP0000465_gastrointestinal_hemorrhage1.52243145
45MP0008469_abnormal_protein_level1.49558261
46MP0009333_abnormal_splenocyte_physiolog1.47451447
47MP0005310_abnormal_salivary_gland1.45878638
48* MP0002398_abnormal_bone_marrow1.43718258
49MP0000689_abnormal_spleen_morphology1.41609720
50MP0002396_abnormal_hematopoietic_system1.40252016
51MP0002933_joint_inflammation1.35955725
52MP0005397_hematopoietic_system_phenotyp1.33939514
53MP0001545_abnormal_hematopoietic_system1.33939514
54MP0010155_abnormal_intestine_physiology1.33901776
55MP0005174_abnormal_tail_pigmentation1.32112634
56MP0008004_abnormal_stomach_pH1.31081264
57MP0002998_abnormal_bone_remodeling1.29324848
58MP0002132_abnormal_respiratory_system1.29236157
59* MP0002429_abnormal_blood_cell1.27882067
60MP0002722_abnormal_immune_system1.23816791
61MP0002166_altered_tumor_susceptibility1.23587741
62MP0003828_pulmonary_edema1.22120568
63MP0005390_skeleton_phenotype1.20836525
64MP0000858_altered_metastatic_potential1.15354094
65MP0005076_abnormal_cell_differentiation1.14070964
66MP0003866_abnormal_defecation1.09829197
67MP0004808_abnormal_hematopoietic_stem1.07560556
68MP0010307_abnormal_tumor_latency1.05761275
69MP0002006_tumorigenesis1.05753140
70MP0009764_decreased_sensitivity_to1.04934028
71* MP0005166_decreased_susceptibility_to1.03659030
72MP0005167_abnormal_blood-brain_barrier1.00004847
73MP0002138_abnormal_hepatobiliary_system0.95737355
74MP0003656_abnormal_erythrocyte_physiolo0.95175340
75MP0000249_abnormal_blood_vessel0.93791649
76MP0005023_abnormal_wound_healing0.93432090
77MP0002277_abnormal_respiratory_mucosa0.92727526
78MP0004883_abnormal_blood_vessel0.92590199
79MP0004381_abnormal_hair_follicle0.92231287
80MP0000015_abnormal_ear_pigmentation0.90070502
81MP0009763_increased_sensitivity_to0.87737369
82MP0003705_abnormal_hypodermis_morpholog0.86685606
83MP0005164_abnormal_response_to0.83837912
84MP0000767_abnormal_smooth_muscle0.82428317
85MP0003329_amyloid_beta_deposits0.81667175
86MP0001873_stomach_inflammation0.81211540
87MP0000490_abnormal_crypts_of0.80815031
88MP0003806_abnormal_nucleotide_metabolis0.80206028
89* MP0003566_abnormal_cell_adhesion0.79433852
90MP0008438_abnormal_cutaneous_collagen0.77064795
91MP0000920_abnormal_myelination0.76521828
92MP0001986_abnormal_taste_sensitivity0.76015323
93MP0003795_abnormal_bone_structure0.74716866
94MP0003045_fibrosis0.72573543
95MP0009765_abnormal_xenobiotic_induced0.69150614
96MP0008874_decreased_physiological_sensi0.68052489
97MP0001915_intracranial_hemorrhage0.67972471
98MP0003091_abnormal_cell_migration0.66819144
99MP0000371_diluted_coat_color0.66496588
100MP0003453_abnormal_keratinocyte_physiol0.66024322
101MP0001663_abnormal_digestive_system0.63967415
102MP0004130_abnormal_muscle_cell0.63955328
103MP0002928_abnormal_bile_duct0.62675400
104MP0008260_abnormal_autophagy0.60951319
105MP0005257_abnormal_intraocular_pressure0.60453606
106MP0000703_abnormal_thymus_morphology0.59832478
107MP0003279_aneurysm0.59489411
108MP0009115_abnormal_fat_cell0.58300986
109MP0002136_abnormal_kidney_physiology0.56466739
110MP0002332_abnormal_exercise_endurance0.55518575
111MP0005319_abnormal_enzyme/_coenzyme0.53578302
112MP0008873_increased_physiological_sensi0.52929671
113MP0002133_abnormal_respiratory_system0.52918161
114MP0005388_respiratory_system_phenotype0.52918161
115MP0001958_emphysema0.51977792
116MP0004185_abnormal_adipocyte_glucose0.49661720

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.64782686
2Eczematoid dermatitis (HP:0000976)7.09763121
3Recurrent gram-negative bacterial infections (HP:0005420)6.71199038
4Recurrent bacterial skin infections (HP:0005406)6.62867771
5* Systemic lupus erythematosus (HP:0002725)6.00641227
6Glomerulonephritis (HP:0000099)5.51030565
7Vacuolated lymphocytes (HP:0001922)4.99722936
8Abnormality of macrophages (HP:0004311)4.96541752
9Increased cerebral lipofuscin (HP:0011813)4.81237370
10Dysostosis multiplex (HP:0000943)4.63188062
11Abnormality of glycolipid metabolism (HP:0010969)4.25213615
12Abnormality of liposaccharide metabolism (HP:0010968)4.25213615
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.25213615
14Increased neuronal autofluorescent lipopigment (HP:0002074)4.18916848
15Gingivitis (HP:0000230)4.11739476
16Obstructive lung disease (HP:0006536)4.06963496
17Chronic obstructive pulmonary disease (HP:0006510)4.06963496
18Mediastinal lymphadenopathy (HP:0100721)3.98961929
19Recurrent skin infections (HP:0001581)3.93964010
20Urinary glycosaminoglycan excretion (HP:0003541)3.72705006
21Mucopolysacchariduria (HP:0008155)3.72705006
22Abnormality of complement system (HP:0005339)3.72545556
23Complement deficiency (HP:0004431)3.67231052
24Disinhibition (HP:0000734)3.60108629
25Recurrent fungal infections (HP:0002841)3.59258252
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.56233063
27Abnormality of polysaccharide metabolism (HP:0011012)3.56233063
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.56233063
29Myositis (HP:0100614)3.40556511
30Gastrointestinal infarctions (HP:0005244)3.31271183
31Nephritis (HP:0000123)3.23828319
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.19997644
33Cellulitis (HP:0100658)3.19042008
34Axonal loss (HP:0003447)3.16255163
35Keratoconjunctivitis sicca (HP:0001097)3.09836681
36Pustule (HP:0200039)3.09791490
37Encephalitis (HP:0002383)3.05520501
38Periodontitis (HP:0000704)3.05446742
39Amyloidosis (HP:0011034)3.02691026
40Orchitis (HP:0100796)2.96304385
41Loss of speech (HP:0002371)2.87658324
42Keratoconjunctivitis (HP:0001096)2.83825801
43Hemoptysis (HP:0002105)2.83648024
44Stomatitis (HP:0010280)2.80644411
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.80642197
46T lymphocytopenia (HP:0005403)2.78307104
47Increased IgE level (HP:0003212)2.74832874
48Prostate neoplasm (HP:0100787)2.72688478
49J-shaped sella turcica (HP:0002680)2.71785106
50Elevated erythrocyte sedimentation rate (HP:0003565)2.67605566
51Urticaria (HP:0001025)2.66130662
52Agnosia (HP:0010524)2.65387552
53Abnormality of T cell number (HP:0011839)2.63712637
54Thoracic kyphosis (HP:0002942)2.62865934
55Hematochezia (HP:0002573)2.61514746
56Chest pain (HP:0100749)2.60926107
57Recurrent viral infections (HP:0004429)2.60229005
58Spondylolisthesis (HP:0003302)2.59944865
59Purpura (HP:0000979)2.55115017
60Spontaneous hematomas (HP:0007420)2.52764426
61Meningitis (HP:0001287)2.51753000
62Retrobulbar optic neuritis (HP:0100654)2.50436827
63Optic neuritis (HP:0100653)2.50436827
64Abnormality of the lumbar spine (HP:0100712)2.48067449
65Mutism (HP:0002300)2.48047855
66Hepatosplenomegaly (HP:0001433)2.44766121
67Recurrent cutaneous fungal infections (HP:0011370)2.44543160
68Chronic mucocutaneous candidiasis (HP:0002728)2.44543160
69Episodic fever (HP:0001954)2.43909848
70Arterial tortuosity (HP:0005116)2.39682271
71Interstitial pulmonary disease (HP:0006530)2.39204125
72Cerebral aneurysm (HP:0004944)2.38229808
73Osteomyelitis (HP:0002754)2.33141110
74Increased serum ferritin (HP:0003281)2.32747072
75Prolonged bleeding time (HP:0003010)2.31216074
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31158384
77Myocardial infarction (HP:0001658)2.29422430
78Pulmonary embolism (HP:0002204)2.29419211
79Anorexia (HP:0002039)2.28935085
80Recurrent pneumonia (HP:0006532)2.27846842
81Arterial thrombosis (HP:0004420)2.26012759
82Leukocytosis (HP:0001974)2.25739222
83Pathologic fracture (HP:0002756)2.22487566
84Thick nail (HP:0001805)2.22330915
85Autoimmune thrombocytopenia (HP:0001973)2.19850865
86Vasculitis (HP:0002633)2.18557273
87Panhypogammaglobulinemia (HP:0003139)2.16628986
88Colitis (HP:0002583)2.16076518
89Asymmetric septal hypertrophy (HP:0001670)2.15903941
90Inflammation of the large intestine (HP:0002037)2.15311534
91Increased IgM level (HP:0003496)2.13439720
92Granulocytopenia (HP:0001913)2.11766514
93Osteolytic defects of the hand bones (HP:0009699)2.11542903
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.11542903
95Abnormality of T cells (HP:0002843)2.10739428
96Abnormality of iron homeostasis (HP:0011031)2.10724715
97Basal ganglia calcification (HP:0002135)2.06569496
98Deformed sella turcica (HP:0002681)2.06011248
99Petechiae (HP:0000967)2.05066752
100Vascular tortuosity (HP:0004948)2.03297498
101Upper motor neuron abnormality (HP:0002127)2.03247699
102Abnormality of the thoracic spine (HP:0100711)2.02667203
103Gangrene (HP:0100758)2.02332729
104Hypochromic microcytic anemia (HP:0004840)2.01149953
105Chronic otitis media (HP:0000389)1.98960084
106Premature loss of primary teeth (HP:0006323)1.98740340
107Vertigo (HP:0002321)1.98323907
108Gastrointestinal inflammation (HP:0004386)1.97428815
109Hypochromic anemia (HP:0001931)1.97344136
110Peritonitis (HP:0002586)1.96720702
111Polyneuropathy (HP:0001271)1.96620824
112IgM deficiency (HP:0002850)1.95871767
113Abnormality of the pleura (HP:0002103)1.95550977
114Apathy (HP:0000741)1.94257984
115Abnormality of the endocardium (HP:0004306)1.93685813
116Diminished motivation (HP:0000745)1.92246041
117Amaurosis fugax (HP:0100576)1.91964619
118Inappropriate behavior (HP:0000719)1.91958461
119Epistaxis (HP:0000421)1.91804330
120Thickened calvaria (HP:0002684)1.91502300
121Neuronal loss in central nervous system (HP:0002529)1.91391800
122Abnormal platelet volume (HP:0011876)1.91189913
123Gingival bleeding (HP:0000225)1.91055888
124Cheilitis (HP:0100825)1.88877754
125Hypergammaglobulinemia (HP:0010702)1.88666879
126Pulmonary infiltrates (HP:0002113)1.88504089
127Slow saccadic eye movements (HP:0000514)1.87085111
128Sepsis (HP:0100806)1.86638657
129Menorrhagia (HP:0000132)1.86570276
130Glomerulopathy (HP:0100820)1.86553510
131Increased CSF protein (HP:0002922)1.84813929
132Progressive visual loss (HP:0000529)1.83598955
133Abnormality of the peritoneum (HP:0002585)1.83571002
134Progressive neurologic deterioration (HP:0002344)1.83413296
135Recurrent lower respiratory tract infections (HP:0002783)1.83095261
136Joint hemorrhage (HP:0005261)1.82167284
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81481170
138Retinal atrophy (HP:0001105)1.81012438
139Absent frontal sinuses (HP:0002688)1.78548505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.51288669
2RIPK43.91555398
3IRAK43.68994455
4TGFBR23.44784793
5MAP4K12.93197320
6PRPF4B2.76320930
7TYK22.61015260
8CSF1R2.44344970
9CAMK1D2.39092510
10ERN12.36387024
11FES2.29301838
12EPHB12.15034726
13TBK12.15022206
14KIT2.12304811
15STK101.96677516
16GRK71.95772439
17FGR1.93320818
18CSK1.90984228
19TAOK31.87591724
20CAMK1G1.86925283
21MAP3K141.80815912
22HCK1.79910023
23IRAK31.71008166
24ZAP701.69209175
25TAOK11.65052667
26TXK1.58386015
27SIK21.56836625
28MST1R1.55902527
29BTK1.54195899
30MAP2K31.52518043
31TRIB31.51829496
32JAK11.44266403
33RIPK11.42479315
34TTN1.41929009
35CLK11.38138066
36SYK1.33384930
37PKN21.32058387
38MAP3K131.31168331
39MARK31.27819318
40LYN1.26665687
41KSR21.22473617
42LCK1.21021596
43IKBKB1.17812259
44PAK41.15146364
45TEC1.15068731
46MATK1.11384216
47IKBKE1.07989374
48TAOK21.07395569
49GRK61.04681568
50TRPM71.03776755
51JAK31.00023012
52PTK60.98931856
53BMPR20.97882164
54ITK0.97734645
55JAK20.94981974
56BMX0.92803875
57CAMKK20.92228982
58IRAK20.91161708
59CDC42BPA0.90715571
60IRAK10.89076436
61MARK20.88682486
62LRRK20.81449121
63RPS6KA40.81049559
64NEK90.80803515
65MAPK70.76850007
66CAMKK10.76014274
67EGFR0.75017592
68MAP3K50.74181668
69MAP3K20.70954340
70MAP3K110.68403378
71MAPKAPK20.60431452
72PIM10.59948392
73FYN0.59860761
74SIK30.58669355
75PRKD20.58332028
76PRKCH0.57145241
77MAP2K40.57143115
78MAP3K30.57006548
79ADRBK20.56738959
80FGFR30.55440194
81SCYL20.55313983
82PRKCD0.54991328
83YES10.52982484
84PRKCQ0.51951062
85DAPK20.48945212
86RET0.48391344
87SGK20.47798299
88IGF1R0.47716874
89RPS6KA60.47647565
90EPHA30.47291269
91ABL10.46695642
92MAPK150.46550907
93PDPK10.46484390
94PDK10.45654273
95MOS0.44350238
96RPS6KC10.44272057
97RPS6KL10.44272057
98MAP2K60.43913109
99RPS6KA20.43686441
100KSR10.43469559
101STK40.42609016
102CDK120.42154561
103CDK60.42152129
104CHUK0.41087869
105PIM20.40986544
106HIPK20.40195999
107DMPK0.40170288
108ALK0.39600141
109STK110.39344192
110MAP3K70.39222584
111RAF10.39158321
112MAP3K90.39074254
113MAPK40.35427917
114DYRK1B0.35155873
115MAP3K60.34868882
116PIK3CG0.31520402
117TESK20.29829656
118SGK30.29003371
119CAMK40.28855537
120MAPK120.27088975
121SRC0.25485843
122PTK2B0.23348051
123MAP3K10.22832748
124TNK20.22446779
125MAP3K80.20339540

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051504.67015840
2Other glycan degradation_Homo sapiens_hsa005113.56470922
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.52807636
4* Leishmaniasis_Homo sapiens_hsa051403.04610611
5Lysosome_Homo sapiens_hsa041422.75416086
6Osteoclast differentiation_Homo sapiens_hsa043802.71505008
7* Pertussis_Homo sapiens_hsa051332.45871944
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18502593
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08558990
10* Tuberculosis_Homo sapiens_hsa051522.06391027
11B cell receptor signaling pathway_Homo sapiens_hsa046621.99466077
12Autoimmune thyroid disease_Homo sapiens_hsa053201.98936086
13Malaria_Homo sapiens_hsa051441.87447885
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.78767318
15* Phagosome_Homo sapiens_hsa041451.76749894
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73616990
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57748564
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.56575815
19Type I diabetes mellitus_Homo sapiens_hsa049401.55854331
20Chemokine signaling pathway_Homo sapiens_hsa040621.54972869
21* Legionellosis_Homo sapiens_hsa051341.53440448
22Salmonella infection_Homo sapiens_hsa051321.51153432
23Toxoplasmosis_Homo sapiens_hsa051451.49053651
24* Complement and coagulation cascades_Homo sapiens_hsa046101.48006844
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45270553
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42449252
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41552000
28Measles_Homo sapiens_hsa051621.39434362
29Antigen processing and presentation_Homo sapiens_hsa046121.38672798
30Rheumatoid arthritis_Homo sapiens_hsa053231.38545631
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37218209
32* Leukocyte transendothelial migration_Homo sapiens_hsa046701.36286825
33Shigellosis_Homo sapiens_hsa051311.34854170
34Caffeine metabolism_Homo sapiens_hsa002321.33660342
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28029773
36* Hematopoietic cell lineage_Homo sapiens_hsa046401.24977355
37Influenza A_Homo sapiens_hsa051641.24254006
38Platelet activation_Homo sapiens_hsa046111.15375305
39TNF signaling pathway_Homo sapiens_hsa046681.14867127
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.14501944
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10606195
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10276040
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09188703
44Asthma_Homo sapiens_hsa053101.05066723
45Apoptosis_Homo sapiens_hsa042101.04838694
46Prion diseases_Homo sapiens_hsa050201.02321975
47Graft-versus-host disease_Homo sapiens_hsa053321.00678630
48Pancreatic cancer_Homo sapiens_hsa052121.00677224
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.99493426
50Hepatitis B_Homo sapiens_hsa051610.98939554
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95930091
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95096276
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93739094
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88807066
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86464049
56Acute myeloid leukemia_Homo sapiens_hsa052210.85135653
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85130295
58Herpes simplex infection_Homo sapiens_hsa051680.84204334
59* Amoebiasis_Homo sapiens_hsa051460.84122665
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.82872433
61Viral myocarditis_Homo sapiens_hsa054160.81654751
62Endocytosis_Homo sapiens_hsa041440.80442501
63Hepatitis C_Homo sapiens_hsa051600.71956708
64T cell receptor signaling pathway_Homo sapiens_hsa046600.71081428
65* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70723640
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.67836484
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65459949
68VEGF signaling pathway_Homo sapiens_hsa043700.64402141
69GnRH signaling pathway_Homo sapiens_hsa049120.63620047
70* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60912765
71Collecting duct acid secretion_Homo sapiens_hsa049660.60524834
72African trypanosomiasis_Homo sapiens_hsa051430.59335877
73Allograft rejection_Homo sapiens_hsa053300.58947283
74Renal cell carcinoma_Homo sapiens_hsa052110.57492109
75Sphingolipid metabolism_Homo sapiens_hsa006000.57465539
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55811645
77Arachidonic acid metabolism_Homo sapiens_hsa005900.54410417
78Proteoglycans in cancer_Homo sapiens_hsa052050.51310365
79HIF-1 signaling pathway_Homo sapiens_hsa040660.51225959
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49937434
81Type II diabetes mellitus_Homo sapiens_hsa049300.49536190
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49149520
83Endometrial cancer_Homo sapiens_hsa052130.48622939
84Non-small cell lung cancer_Homo sapiens_hsa052230.47889565
85Choline metabolism in cancer_Homo sapiens_hsa052310.47335564
86Notch signaling pathway_Homo sapiens_hsa043300.47277650
87mTOR signaling pathway_Homo sapiens_hsa041500.47142525
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45960563
89Colorectal cancer_Homo sapiens_hsa052100.43356876
90* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42070217
91Prolactin signaling pathway_Homo sapiens_hsa049170.40887680
92Primary immunodeficiency_Homo sapiens_hsa053400.40260066
93Galactose metabolism_Homo sapiens_hsa000520.39950091
94ABC transporters_Homo sapiens_hsa020100.39595029
95Estrogen signaling pathway_Homo sapiens_hsa049150.38208189
96Insulin resistance_Homo sapiens_hsa049310.38129869
97Adherens junction_Homo sapiens_hsa045200.37099971
98* Rap1 signaling pathway_Homo sapiens_hsa040150.36415598
99Epstein-Barr virus infection_Homo sapiens_hsa051690.35996538
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35794192
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.34106974
102MAPK signaling pathway_Homo sapiens_hsa040100.33085128
103Small cell lung cancer_Homo sapiens_hsa052220.32971472
104Dorso-ventral axis formation_Homo sapiens_hsa043200.31972274
105Focal adhesion_Homo sapiens_hsa045100.31841055
106Viral carcinogenesis_Homo sapiens_hsa052030.31284538
107Mineral absorption_Homo sapiens_hsa049780.27712908
108Glioma_Homo sapiens_hsa052140.27697203
109HTLV-I infection_Homo sapiens_hsa051660.26425806
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.25778951
111FoxO signaling pathway_Homo sapiens_hsa040680.24907522
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23320360
113Inositol phosphate metabolism_Homo sapiens_hsa005620.23283140

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