ITGAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.31850376
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.23488640
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.23488640
4negative T cell selection (GO:0043383)6.18143911
5negative thymic T cell selection (GO:0045060)5.98136380
6negative regulation of cell killing (GO:0031342)5.85788773
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.85788773
8regulation of gamma-delta T cell differentiation (GO:0045586)5.80570504
9positive thymic T cell selection (GO:0045059)5.61637681
10antigen processing and presentation of endogenous antigen (GO:0019883)5.61080642
11regulation of gamma-delta T cell activation (GO:0046643)5.49567963
12interferon-gamma production (GO:0032609)5.40623300
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.37055337
14leukocyte aggregation (GO:0070486)5.33669052
15response to interleukin-15 (GO:0070672)5.30806043
16positive T cell selection (GO:0043368)5.14873296
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.12664775
18thymic T cell selection (GO:0045061)5.05412990
19T cell migration (GO:0072678)4.97760954
20T cell selection (GO:0045058)4.88731599
21cellular response to interleukin-15 (GO:0071350)4.79446971
22regulation of isotype switching to IgG isotypes (GO:0048302)4.71701773
23regulation of B cell receptor signaling pathway (GO:0050855)4.64012938
24tolerance induction (GO:0002507)4.43784347
25neutrophil activation involved in immune response (GO:0002283)4.33944922
26detection of other organism (GO:0098543)4.26315934
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.21746158
28detection of bacterium (GO:0016045)4.19482711
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18403437
30regulation of interleukin-2 biosynthetic process (GO:0045076)4.17836875
31regulation of interleukin-12 biosynthetic process (GO:0045075)4.04153548
32macrophage activation involved in immune response (GO:0002281)4.04092283
33regulation of alpha-beta T cell proliferation (GO:0046640)3.98147102
34T cell receptor signaling pathway (GO:0050852)3.97953904
35positive regulation of isotype switching (GO:0045830)3.94897976
36T cell costimulation (GO:0031295)3.94491636
37positive regulation of interleukin-2 production (GO:0032743)3.91539663
38regulation of natural killer cell mediated immunity (GO:0002715)3.87976607
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.87976607
40lymphocyte costimulation (GO:0031294)3.87640101
41negative regulation of leukocyte mediated immunity (GO:0002704)3.84705870
42regulation of B cell differentiation (GO:0045577)3.83526174
43regulation of T cell tolerance induction (GO:0002664)3.72201884
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.69701533
45antigen receptor-mediated signaling pathway (GO:0050851)3.67863175
46negative regulation of erythrocyte differentiation (GO:0045647)3.66766884
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.66351416
48positive regulation of granulocyte differentiation (GO:0030854)3.62004772
49response to peptidoglycan (GO:0032494)3.54885170
50positive regulation of B cell mediated immunity (GO:0002714)3.51230426
51positive regulation of immunoglobulin mediated immune response (GO:0002891)3.51230426
52myeloid cell activation involved in immune response (GO:0002275)3.50855138
53positive regulation of B cell differentiation (GO:0045579)3.50194089
54negative regulation of T cell mediated immunity (GO:0002710)3.49061697
55respiratory burst (GO:0045730)3.43573422
56neutrophil activation (GO:0042119)3.43409905
57* activated T cell proliferation (GO:0050798)3.43072650
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42716559
59negative regulation of interleukin-12 production (GO:0032695)3.42356375
60positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.40750736
61positive regulation of natural killer cell mediated immunity (GO:0002717)3.40750736
62detection of external biotic stimulus (GO:0098581)3.40482687
63natural killer cell activation (GO:0030101)3.40204994
64JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.40133810
65B cell receptor signaling pathway (GO:0050853)3.38063211
66positive regulation of humoral immune response (GO:0002922)3.36770448
67regulation of T cell receptor signaling pathway (GO:0050856)3.36316934
68* leukocyte cell-cell adhesion (GO:0007159)3.35544629
69positive regulation of DNA recombination (GO:0045911)3.34320385
70mast cell activation (GO:0045576)3.33970950
71NIK/NF-kappaB signaling (GO:0038061)3.30806656
72regulation of T cell mediated cytotoxicity (GO:0001914)3.29589694
73regulation of isotype switching (GO:0045191)3.24698985
74microglial cell activation (GO:0001774)3.22875906
75regulation of interferon-beta biosynthetic process (GO:0045357)3.22135042
76regulation of type I interferon-mediated signaling pathway (GO:0060338)3.20984793
77leukocyte degranulation (GO:0043299)3.19797518
78positive regulation of tolerance induction (GO:0002645)3.19530097
79regulation of response to interferon-gamma (GO:0060330)3.17233486
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16082778
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14638080
82regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14531874
83negative regulation of phagocytosis (GO:0050765)3.13878997
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13507491
85response to type I interferon (GO:0034340)3.11699894
86granulocyte activation (GO:0036230)3.11590794
87regulation of immunoglobulin mediated immune response (GO:0002889)3.10461145
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.10350577
89regulation of interleukin-2 production (GO:0032663)3.08734746
90T cell homeostasis (GO:0043029)3.08669914
91myeloid dendritic cell activation (GO:0001773)3.08181383
92defense response to protozoan (GO:0042832)3.07971593
93regulation of B cell mediated immunity (GO:0002712)3.07565877
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06818426
95response to host immune response (GO:0052572)3.06818426
96cellular response to type I interferon (GO:0071357)3.06401070
97type I interferon signaling pathway (GO:0060337)3.06401070
98regulation of mast cell degranulation (GO:0043304)3.06227017
99alpha-beta T cell activation (GO:0046631)3.04101534
100detection of biotic stimulus (GO:0009595)3.02848503
101interferon-gamma-mediated signaling pathway (GO:0060333)3.02450142
102cellular extravasation (GO:0045123)3.02406814
103cellular defense response (GO:0006968)3.01135781
104response to protozoan (GO:0001562)2.99917002
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98813020
106regulation of regulatory T cell differentiation (GO:0045589)2.98779948
107positive regulation of immunoglobulin production (GO:0002639)2.98295118
108regulation of cell killing (GO:0031341)2.96930809
109positive regulation of mast cell activation (GO:0033005)2.96250919
110negative regulation of lymphocyte mediated immunity (GO:0002707)2.96141422
111negative regulation of innate immune response (GO:0045824)2.96069825
112regulation of tolerance induction (GO:0002643)2.93852174
113response to muramyl dipeptide (GO:0032495)2.92963309
114negative regulation of T-helper cell differentiation (GO:0045623)2.92337244
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92337244
116positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.91790645
117negative regulation of adaptive immune response (GO:0002820)2.91559544
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91006506
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.91006506
120modulation by symbiont of host immune response (GO:0052553)2.91006506
121positive regulation by symbiont of host defense response (GO:0052509)2.91006506
122modulation by symbiont of host defense response (GO:0052031)2.91006506
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91006506
124antigen processing and presentation via MHC class Ib (GO:0002475)2.90400541
125lymphocyte homeostasis (GO:0002260)2.90015110
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89899597
127detection of molecule of bacterial origin (GO:0032490)2.89838109
128immunoglobulin mediated immune response (GO:0016064)2.89767796
129immune response-activating cell surface receptor signaling pathway (GO:0002429)2.88754437
130lymphocyte migration (GO:0072676)2.87663862
131negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.86146740
132myeloid dendritic cell differentiation (GO:0043011)2.84527843
133natural killer cell differentiation (GO:0001779)2.84128220
134alpha-beta T cell differentiation (GO:0046632)2.84035753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.18939312
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.31004259
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.53418884
4E2F7_22180533_ChIP-Seq_HELA_Human4.18237375
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67648864
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.61107462
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.41908678
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35779883
9MYC_22102868_ChIP-Seq_BL_Human3.32112266
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31914714
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.25070214
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.19562376
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.15001937
14RUNX_20019798_ChIP-Seq_JUKART_Human3.10683607
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.00694447
16* MYB_26560356_Chip-Seq_TH2_Human2.96534069
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74561441
18* MAF_26560356_Chip-Seq_TH1_Human2.73071331
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65324635
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64929695
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.61309224
22VDR_21846776_ChIP-Seq_THP-1_Human2.59527423
23MYB_26560356_Chip-Seq_TH1_Human2.58557820
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56714564
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53119643
26UTX_26944678_Chip-Seq_JUKART_Human2.43898915
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21282571
28* SPI1_23547873_ChIP-Seq_NB4_Human2.13380453
29SCL_19346495_ChIP-Seq_HPC-7_Human2.11152525
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07170067
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.05209492
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04162273
33VDR_24763502_ChIP-Seq_THP-1_Human2.02556639
34TCF7_22412390_ChIP-Seq_EML_Mouse1.98597480
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97193539
36* MAF_26560356_Chip-Seq_TH2_Human1.84904594
37GATA3_27048872_Chip-Seq_THYMUS_Human1.84799440
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83775267
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82456108
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79358990
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65249463
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.63886460
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.63345284
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62688007
45SPI1_23127762_ChIP-Seq_K562_Human1.62011320
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58956920
47KDM2B_26808549_Chip-Seq_DND41_Human1.57413996
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57243151
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56826089
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56346183
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55929303
52PU_27001747_Chip-Seq_BMDM_Mouse1.44048259
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42940895
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38697874
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35222361
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35014653
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33743838
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33252374
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32996472
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31383128
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30826994
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29007975
63GATA3_26560356_Chip-Seq_TH2_Human1.23045784
64CIITA_25753668_ChIP-Seq_RAJI_Human1.21072304
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.20205562
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17934971
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17496846
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14542125
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12481657
70* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12204765
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11529747
72GATA1_19941826_ChIP-Seq_K562_Human1.11509141
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10531279
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09540397
75* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09207377
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08025209
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05234784
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04060565
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01469099
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98450448
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.95633426
82* BCL6_27268052_Chip-Seq_Bcells_Human0.95387042
83KDM2B_26808549_Chip-Seq_JURKAT_Human0.94881256
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93601550
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.93293470
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92992428
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92599772
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92472758
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90857053
90* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90807664
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90774357
92NCOR1_26117541_ChIP-Seq_K562_Human0.88805230
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87924883
94* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86716269
95* BCOR_27268052_Chip-Seq_Bcells_Human0.84794157
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84509529
97VDR_24787735_ChIP-Seq_THP-1_Human0.84121081
98SPI1_20517297_ChIP-Seq_HL60_Human0.82548332
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81540768
100* VDR_23849224_ChIP-Seq_CD4+_Human0.79604146
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78985007
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78933153
103* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78464755
104FOXP3_21729870_ChIP-Seq_TREG_Human0.78126424
105* ELF1_20517297_ChIP-Seq_JURKAT_Human0.78086384
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77286058
107GATA1_22025678_ChIP-Seq_K562_Human0.72281810
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71259596
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70641562
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68953839
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.68372358
112GATA2_19941826_ChIP-Seq_K562_Human0.68005204
113* LXR_22292898_ChIP-Seq_THP-1_Human0.66793243
114TFEB_21752829_ChIP-Seq_HELA_Human0.65867545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.96387485
2MP0003763_abnormal_thymus_physiology3.92426669
3MP0001835_abnormal_antigen_presentation3.89076411
4MP0000685_abnormal_immune_system3.39994896
5* MP0001800_abnormal_humoral_immune3.24472691
6MP0001790_abnormal_immune_system3.23227511
7MP0005387_immune_system_phenotype3.23227511
8MP0003436_decreased_susceptibility_to3.14530982
9MP0009785_altered_susceptibility_to3.11926914
10MP0005000_abnormal_immune_tolerance3.11317554
11* MP0002723_abnormal_immune_serum2.84716330
12MP0003303_peritoneal_inflammation2.82622289
13MP0002452_abnormal_antigen_presenting2.80528453
14* MP0002420_abnormal_adaptive_immunity2.79134239
15MP0005025_abnormal_response_to2.78372815
16* MP0001819_abnormal_immune_cell2.76327772
17MP0006082_CNS_inflammation2.72283531
18* MP0002398_abnormal_bone_marrow2.58267667
19MP0002405_respiratory_system_inflammati2.45733935
20MP0002166_altered_tumor_susceptibility2.41179217
21* MP0002419_abnormal_innate_immunity2.40320443
22MP0009333_abnormal_splenocyte_physiolog2.39003602
23MP0002148_abnormal_hypersensitivity_rea2.37705371
24* MP0000716_abnormal_immune_system2.32430368
25MP0003300_gastrointestinal_ulcer2.27791091
26MP0002006_tumorigenesis2.26190865
27MP0010155_abnormal_intestine_physiology2.22239391
28MP0002396_abnormal_hematopoietic_system2.21406262
29MP0001873_stomach_inflammation2.20989561
30MP0003724_increased_susceptibility_to2.20822740
31MP0000703_abnormal_thymus_morphology2.11908339
32MP0004947_skin_inflammation2.10070147
33* MP0002722_abnormal_immune_system2.07554118
34* MP0000689_abnormal_spleen_morphology2.06805395
35MP0005464_abnormal_platelet_physiology1.98262301
36MP0004510_myositis1.91972860
37* MP0002429_abnormal_blood_cell1.91523150
38MP0003866_abnormal_defecation1.86854340
39* MP0001845_abnormal_inflammatory_respons1.85119737
40MP0001853_heart_inflammation1.76971410
41MP0002933_joint_inflammation1.70237642
42MP0009278_abnormal_bone_marrow1.62915527
43MP0003448_altered_tumor_morphology1.60850981
44MP0004808_abnormal_hematopoietic_stem1.59405702
45MP0001545_abnormal_hematopoietic_system1.49539615
46MP0005397_hematopoietic_system_phenotyp1.49539615
47MP0008260_abnormal_autophagy1.46223060
48MP0001533_abnormal_skeleton_physiology1.45299655
49MP0005310_abnormal_salivary_gland1.34366880
50MP0005451_abnormal_body_composition1.34058287
51* MP0008469_abnormal_protein_level1.33692265
52MP0000465_gastrointestinal_hemorrhage1.30933926
53* MP0000858_altered_metastatic_potential1.29393840
54MP0000490_abnormal_crypts_of1.24371937
55MP0004883_abnormal_blood_vessel1.21669455
56MP0010352_gastrointestinal_tract_polyps1.13522200
57MP0005076_abnormal_cell_differentiation1.13359618
58MP0003690_abnormal_glial_cell1.07818353
59MP0005174_abnormal_tail_pigmentation1.05525210
60MP0002019_abnormal_tumor_incidence1.03212591
61MP0002132_abnormal_respiratory_system1.03021982
62MP0001851_eye_inflammation1.01259603
63MP0003172_abnormal_lysosome_physiology1.00652827
64MP0009764_decreased_sensitivity_to0.99469722
65MP0010307_abnormal_tumor_latency0.97618042
66MP0008057_abnormal_DNA_replication0.97009558
67MP0002998_abnormal_bone_remodeling0.96244735
68MP0001986_abnormal_taste_sensitivity0.92426790
69MP0002277_abnormal_respiratory_mucosa0.88453106
70MP0009763_increased_sensitivity_to0.85340190
71MP0005058_abnormal_lysosome_morphology0.84745778
72MP0000343_altered_response_to0.79730944
73MP0000569_abnormal_digit_pigmentation0.77897668
74MP0004381_abnormal_hair_follicle0.75986283
75MP0005023_abnormal_wound_healing0.75858386
76MP0005164_abnormal_response_to0.71918495
77MP0005166_decreased_susceptibility_to0.71673782
78MP0002138_abnormal_hepatobiliary_system0.70908188
79MP0008961_abnormal_basal_metabolism0.70464915
80MP0001663_abnormal_digestive_system0.68859331
81MP0005075_abnormal_melanosome_morpholog0.68737732
82MP0003077_abnormal_cell_cycle0.67204137
83MP0003183_abnormal_peptide_metabolism0.66526624
84MP0004130_abnormal_muscle_cell0.65946418
85MP0000609_abnormal_liver_physiology0.63240085
86MP0000604_amyloidosis0.62862234
87MP0003566_abnormal_cell_adhesion0.62803734
88MP0009765_abnormal_xenobiotic_induced0.62017626
89MP0003453_abnormal_keratinocyte_physiol0.61037958
90MP0000015_abnormal_ear_pigmentation0.60575212
91MP0003191_abnormal_cellular_cholesterol0.60548346
92MP0003693_abnormal_embryo_hatching0.60071182
93MP0010094_abnormal_chromosome_stability0.58138717
94MP0003795_abnormal_bone_structure0.56910246
95MP0003828_pulmonary_edema0.55972695
96MP0002136_abnormal_kidney_physiology0.55299107
97MP0003045_fibrosis0.55013409
98MP0003091_abnormal_cell_migration0.54779215
99MP0003656_abnormal_erythrocyte_physiolo0.53751179
100MP0000249_abnormal_blood_vessel0.53637090
101MP0008004_abnormal_stomach_pH0.53315226
102MP0002693_abnormal_pancreas_physiology0.53287102
103MP0005390_skeleton_phenotype0.52969051
104MP0008873_increased_physiological_sensi0.51503341
105MP0008874_decreased_physiological_sensi0.50813748
106MP0000371_diluted_coat_color0.50295071
107MP0000313_abnormal_cell_death0.49534979
108MP0003075_altered_response_to0.49133899
109MP0000477_abnormal_intestine_morphology0.48844346
110MP0009840_abnormal_foam_cell0.47779694
111MP0002009_preneoplasia0.46889281
112MP0005381_digestive/alimentary_phenotyp0.46777038
113MP0001191_abnormal_skin_condition0.45665467
114MP0009115_abnormal_fat_cell0.45123694
115MP0002928_abnormal_bile_duct0.40740741

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.83040725
2Abnormality of T cell number (HP:0011839)5.61355017
3Eczematoid dermatitis (HP:0000976)5.23360938
4Elevated erythrocyte sedimentation rate (HP:0003565)5.02653417
5Recurrent fungal infections (HP:0002841)4.85148075
6Recurrent viral infections (HP:0004429)4.84703768
7Recurrent abscess formation (HP:0002722)4.76165888
8Myositis (HP:0100614)4.65958063
9Stomatitis (HP:0010280)4.55077101
10Abnormality of T cells (HP:0002843)4.44664817
11Chronic otitis media (HP:0000389)4.29793407
12Nasal polyposis (HP:0100582)4.27861659
13IgM deficiency (HP:0002850)4.24808775
14Panhypogammaglobulinemia (HP:0003139)4.23495351
15Recurrent bronchitis (HP:0002837)4.14882731
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.98834906
17Recurrent bacterial skin infections (HP:0005406)3.98670319
18Retrobulbar optic neuritis (HP:0100654)3.93443330
19Optic neuritis (HP:0100653)3.93443330
20Chronic mucocutaneous candidiasis (HP:0002728)3.87207494
21Recurrent cutaneous fungal infections (HP:0011370)3.87207494
22Pustule (HP:0200039)3.76364901
23Mediastinal lymphadenopathy (HP:0100721)3.75369827
24Meningitis (HP:0001287)3.73978081
25Severe combined immunodeficiency (HP:0004430)3.73243778
26Orchitis (HP:0100796)3.69345739
27Combined immunodeficiency (HP:0005387)3.66140636
28Abnormality of the nasal mucosa (HP:0000433)3.61126040
29Vasculitis (HP:0002633)3.55506056
30Abnormality of B cell number (HP:0010975)3.39178242
31B lymphocytopenia (HP:0010976)3.39178242
32Chronic obstructive pulmonary disease (HP:0006510)3.38761013
33Obstructive lung disease (HP:0006536)3.38761013
34Recurrent skin infections (HP:0001581)3.35071664
35Autoimmune thrombocytopenia (HP:0001973)3.33507297
36Inflammation of the large intestine (HP:0002037)3.32951095
37Recurrent gram-negative bacterial infections (HP:0005420)3.26830484
38Abnormality of T cell physiology (HP:0011840)3.24492385
39Gastrointestinal inflammation (HP:0004386)3.24235969
40Eosinophilia (HP:0001880)3.22406231
41Abnormality of the fingertips (HP:0001211)3.21795833
42IgG deficiency (HP:0004315)3.18828390
43Leukocytosis (HP:0001974)3.18783585
44Abnormality of macrophages (HP:0004311)3.14326790
45Spontaneous hematomas (HP:0007420)3.05881445
46Encephalitis (HP:0002383)3.04872076
47Pulmonary infiltrates (HP:0002113)3.03696483
48Lymphopenia (HP:0001888)3.01378190
49Hemoptysis (HP:0002105)2.98248907
50Abnormality of eosinophils (HP:0001879)2.97115604
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.93016320
52Thyroiditis (HP:0100646)2.91358329
53Joint swelling (HP:0001386)2.90584829
54Chronic diarrhea (HP:0002028)2.85970251
55Granulocytopenia (HP:0001913)2.82732784
56Arterial thrombosis (HP:0004420)2.76958081
57Gastrointestinal infarctions (HP:0005244)2.75979362
58Keratoconjunctivitis sicca (HP:0001097)2.73652625
59Increased IgE level (HP:0003212)2.73158785
60Periodontitis (HP:0000704)2.69471237
61IgA deficiency (HP:0002720)2.68721755
62Colitis (HP:0002583)2.66243522
63Gingivitis (HP:0000230)2.64073940
64Agammaglobulinemia (HP:0004432)2.62892561
65Recurrent sinusitis (HP:0011108)2.62794800
66Cellulitis (HP:0100658)2.60001246
67Hypochromic anemia (HP:0001931)2.53850707
68Keratoconjunctivitis (HP:0001096)2.47963389
69Chest pain (HP:0100749)2.46729004
70Increased IgM level (HP:0003496)2.46605801
71Thrombocytosis (HP:0001894)2.46272572
72Lymphoma (HP:0002665)2.45676864
73Prolonged bleeding time (HP:0003010)2.42499341
74Autoimmune hemolytic anemia (HP:0001890)2.42213484
75Papilledema (HP:0001085)2.41889317
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41233080
77Gingival bleeding (HP:0000225)2.40127999
78Epistaxis (HP:0000421)2.39884587
79Verrucae (HP:0200043)2.33547289
80Papilloma (HP:0012740)2.33547289
81Hypergammaglobulinemia (HP:0010702)2.31662818
82Pulmonary embolism (HP:0002204)2.29658693
83Gastrointestinal stroma tumor (HP:0100723)2.29167886
84Bronchitis (HP:0012387)2.28023602
85Chronic sinusitis (HP:0011109)2.27340905
86Episodic fever (HP:0001954)2.26359942
87Interstitial pulmonary disease (HP:0006530)2.20202348
88Sepsis (HP:0100806)2.19839696
89Viral hepatitis (HP:0006562)2.18882596
90Cheilitis (HP:0100825)2.17303057
91Increased density of long bones (HP:0006392)2.17223325
92Abnormality of the prostate (HP:0008775)2.16064234
93Hypochromic microcytic anemia (HP:0004840)2.14566617
94Emphysema (HP:0002097)2.14378085
95Petechiae (HP:0000967)2.13729504
96Slow saccadic eye movements (HP:0000514)2.13062455
97Hypoplasia of the thymus (HP:0000778)2.12189659
98Hemiplegia (HP:0002301)2.10981047
99Abnormal platelet volume (HP:0011876)2.10423865
100Skin ulcer (HP:0200042)2.08451080
101Microcytic anemia (HP:0001935)2.02388329
102Increased serum ferritin (HP:0003281)1.97645651
103Arthralgia (HP:0002829)1.97606493
104Glomerulopathy (HP:0100820)1.96883888
105Amaurosis fugax (HP:0100576)1.94956507
106Urticaria (HP:0001025)1.94359577
107Acute hepatic failure (HP:0006554)1.94185850
108Osteomyelitis (HP:0002754)1.93885739
109Gangrene (HP:0100758)1.92074799
110Restrictive lung disease (HP:0002091)1.91034311
111Purpura (HP:0000979)1.90028594
112Keratitis (HP:0000491)1.87829236
113Basal cell carcinoma (HP:0002671)1.87626887
114Anorexia (HP:0002039)1.84460315
115Abnormality of the endocardium (HP:0004306)1.80185184
116Abnormality of the pleura (HP:0002103)1.79786858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.68237599
2TXK4.71145227
3JAK33.54077551
4PRPF4B3.14882984
5TYK22.87075147
6ITK2.79000694
7ZAP702.73907485
8MAP3K142.63836979
9STK102.52640985
10IKBKE2.25316856
11FGFR42.20740910
12JAK12.16441054
13BLK2.05129332
14GRK61.99217893
15TBK11.95737114
16CSK1.87844950
17EEF2K1.87032337
18LCK1.76946830
19IRAK41.74442532
20BTK1.72155379
21SYK1.66838233
22MAP3K101.66103703
23FGFR31.60814307
24TEC1.59535415
25HCK1.55249451
26RIPK41.46554439
27KIT1.41858846
28MAP3K131.39993544
29IKBKB1.35693574
30CDK121.35382280
31EPHB11.34252718
32IRAK31.30755644
33FES1.30567671
34TRIB31.29009200
35NLK1.20704350
36MARK31.19538470
37PIM11.19395137
38SIK21.18987432
39MST41.17588785
40LRRK21.16405103
41CLK11.14708457
42PRKCQ1.12033169
43RPS6KA41.11339988
44MAP3K31.10247496
45CSF1R1.09993886
46JAK21.07560296
47PKN21.03730174
48PRKCH1.01523304
49TAOK30.99238303
50MAP3K10.98531646
51ERN10.96930994
52NME20.96497931
53CHUK0.96222160
54LYN0.94479575
55MAP2K30.87997620
56MAPK120.87104654
57BMPR20.86982034
58CDK40.84497988
59SMG10.83024282
60YES10.82079205
61KDR0.78810830
62TTN0.77166693
63TNK20.76325599
64ALK0.75913901
65MAP3K70.75444649
66KSR20.74033637
67PIK3CG0.73078740
68EPHA30.71654764
69CAMKK20.71415384
70TGFBR20.69775678
71SIK30.69375817
72TESK20.68701108
73PTK60.65947796
74CDC42BPA0.65571348
75PTK2B0.64328545
76PRKD20.60529367
77CAMKK10.60314866
78STK40.56987501
79PDGFRB0.56088973
80PDPK10.55916545
81NEK20.54371500
82PDK10.50529289
83CDK60.49975410
84TAOK10.49509912
85STK110.45712095
86PASK0.45695058
87MATK0.45606698
88RET0.45035955
89TAOK20.44890564
90GRK70.44800112
91HIPK20.44233849
92TRPM70.44230426
93MELK0.43574820
94FLT30.43236670
95BRD40.39207136
96EGFR0.39030608
97STK240.38248686
98FGR0.37783352
99CDK90.37296609
100MAP3K80.37235499
101RPS6KL10.37119673
102RPS6KC10.37119673
103PIM20.35617747
104NEK90.35199188
105FYN0.34796905
106MAPK40.34757522
107STK380.32961746
108SGK20.32487780
109ABL10.32174867
110DYRK1B0.31792500
111RPS6KA60.31153784
112DMPK0.30920314
113IRAK10.30211939
114MAP3K60.30095034
115INSR0.29594217
116MAP3K20.29553555
117MAP3K110.29122603
118MAPK110.27662749
119MAPKAPK20.27507027
120MAP2K60.26483552
121IRAK20.26257915
122TYRO30.25257874
123MARK20.24838691
124IGF1R0.24715904
125SIK10.24642341
126CDC70.24118027
127MAPK30.22700064
128SGK30.20751056
129MAPK70.20482571
130RAF10.19871682

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.34068050
2Graft-versus-host disease_Homo sapiens_hsa053323.24344197
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.20362321
4T cell receptor signaling pathway_Homo sapiens_hsa046603.02414931
5Leishmaniasis_Homo sapiens_hsa051402.75395880
6* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.74727774
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.69506451
8Measles_Homo sapiens_hsa051622.68485239
9Allograft rejection_Homo sapiens_hsa053302.63007126
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.59009858
11Antigen processing and presentation_Homo sapiens_hsa046122.46033452
12B cell receptor signaling pathway_Homo sapiens_hsa046622.30377283
13Osteoclast differentiation_Homo sapiens_hsa043802.29741175
14Hematopoietic cell lineage_Homo sapiens_hsa046402.07655536
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78873194
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.78591498
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78191833
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71900167
19Autoimmune thyroid disease_Homo sapiens_hsa053201.69240610
20Herpes simplex infection_Homo sapiens_hsa051681.66586610
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63848913
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59905856
23Toxoplasmosis_Homo sapiens_hsa051451.53408478
24Chemokine signaling pathway_Homo sapiens_hsa040621.51821595
25Legionellosis_Homo sapiens_hsa051341.51639377
26Type I diabetes mellitus_Homo sapiens_hsa049401.51242683
27Influenza A_Homo sapiens_hsa051641.46217516
28TNF signaling pathway_Homo sapiens_hsa046681.43122433
29Acute myeloid leukemia_Homo sapiens_hsa052211.43096785
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42892252
31Hepatitis B_Homo sapiens_hsa051611.39786360
32Tuberculosis_Homo sapiens_hsa051521.38336574
33Shigellosis_Homo sapiens_hsa051311.34858874
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34112682
35* Viral myocarditis_Homo sapiens_hsa054161.33639989
36Asthma_Homo sapiens_hsa053101.31818293
37Pertussis_Homo sapiens_hsa051331.28446570
38* Leukocyte transendothelial migration_Homo sapiens_hsa046701.25644113
39Apoptosis_Homo sapiens_hsa042101.23482969
40Chronic myeloid leukemia_Homo sapiens_hsa052201.19487926
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16751960
42* Staphylococcus aureus infection_Homo sapiens_hsa051501.13793620
43Pancreatic cancer_Homo sapiens_hsa052121.06297953
44* Malaria_Homo sapiens_hsa051440.99062592
45Salmonella infection_Homo sapiens_hsa051320.96045218
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95908318
47Hepatitis C_Homo sapiens_hsa051600.93656802
48Platelet activation_Homo sapiens_hsa046110.92732700
49* HTLV-I infection_Homo sapiens_hsa051660.90653327
50* Epstein-Barr virus infection_Homo sapiens_hsa051690.89930753
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88853269
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86266521
53Prolactin signaling pathway_Homo sapiens_hsa049170.84174578
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.80949030
55Viral carcinogenesis_Homo sapiens_hsa052030.80511228
56Choline metabolism in cancer_Homo sapiens_hsa052310.75842233
57VEGF signaling pathway_Homo sapiens_hsa043700.75626640
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75038241
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68991083
60Non-small cell lung cancer_Homo sapiens_hsa052230.68423787
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.68250915
62Colorectal cancer_Homo sapiens_hsa052100.67414257
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66162854
64Small cell lung cancer_Homo sapiens_hsa052220.63178367
65DNA replication_Homo sapiens_hsa030300.60055070
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59008444
67GnRH signaling pathway_Homo sapiens_hsa049120.57976041
68Non-homologous end-joining_Homo sapiens_hsa034500.57908285
69African trypanosomiasis_Homo sapiens_hsa051430.57622791
70* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57481130
71* Rheumatoid arthritis_Homo sapiens_hsa053230.56300960
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55323746
73Base excision repair_Homo sapiens_hsa034100.51666398
74Notch signaling pathway_Homo sapiens_hsa043300.50024904
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49595120
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.45155711
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44322419
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42660888
79Renal cell carcinoma_Homo sapiens_hsa052110.42428548
80* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42058427
81p53 signaling pathway_Homo sapiens_hsa041150.41853003
82Insulin resistance_Homo sapiens_hsa049310.41808780
83FoxO signaling pathway_Homo sapiens_hsa040680.41432054
84HIF-1 signaling pathway_Homo sapiens_hsa040660.41081225
85Type II diabetes mellitus_Homo sapiens_hsa049300.40869345
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.40613608
87ErbB signaling pathway_Homo sapiens_hsa040120.39906984
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.39377841
89Other glycan degradation_Homo sapiens_hsa005110.37997404
90Endocytosis_Homo sapiens_hsa041440.37341195
91mTOR signaling pathway_Homo sapiens_hsa041500.35885471
92Glioma_Homo sapiens_hsa052140.35315150
93Prostate cancer_Homo sapiens_hsa052150.34789493
94MAPK signaling pathway_Homo sapiens_hsa040100.33811696
95MicroRNAs in cancer_Homo sapiens_hsa052060.33649357
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33594367
97Long-term potentiation_Homo sapiens_hsa047200.33372112
98Ras signaling pathway_Homo sapiens_hsa040140.33273203
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32163976
100Lysosome_Homo sapiens_hsa041420.31900774
101Estrogen signaling pathway_Homo sapiens_hsa049150.31680880
102Caffeine metabolism_Homo sapiens_hsa002320.31077760
103* Rap1 signaling pathway_Homo sapiens_hsa040150.29805599
104Spliceosome_Homo sapiens_hsa030400.29617384
105Phagosome_Homo sapiens_hsa041450.28350555
106Regulation of autophagy_Homo sapiens_hsa041400.26323930
107Endometrial cancer_Homo sapiens_hsa052130.26123504
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25698049
109One carbon pool by folate_Homo sapiens_hsa006700.25280125
110Amoebiasis_Homo sapiens_hsa051460.24900031
111Inositol phosphate metabolism_Homo sapiens_hsa005620.22455627
112Proteoglycans in cancer_Homo sapiens_hsa052050.22334645
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21798318
114Dorso-ventral axis formation_Homo sapiens_hsa043200.21631513
115Ribosome_Homo sapiens_hsa030100.20200126
116Mismatch repair_Homo sapiens_hsa034300.19662093
117Pathways in cancer_Homo sapiens_hsa052000.18725501
118Lysine degradation_Homo sapiens_hsa003100.17313370

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