ITGAE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.39409674
2antigen processing and presentation of endogenous antigen (GO:0019883)6.44781323
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.39058386
4negative T cell selection (GO:0043383)6.09736400
5negative thymic T cell selection (GO:0045060)5.95807868
6pinocytosis (GO:0006907)5.92191497
7ATP synthesis coupled proton transport (GO:0015986)5.88914404
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.88914404
9regulation of phospholipase A2 activity (GO:0032429)5.87987369
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78291062
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78291062
12positive thymic T cell selection (GO:0045059)5.53681287
13interferon-gamma production (GO:0032609)5.48398430
14intracellular pH reduction (GO:0051452)5.42225007
15protein complex biogenesis (GO:0070271)5.38944119
16establishment of protein localization to mitochondrial membrane (GO:0090151)5.31568905
17thymic T cell selection (GO:0045061)5.30507362
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.26056704
19protein neddylation (GO:0045116)5.25332323
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.23552347
21mitochondrial respiratory chain complex I assembly (GO:0032981)5.23552347
22NADH dehydrogenase complex assembly (GO:0010257)5.23552347
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.22158451
24chaperone-mediated protein transport (GO:0072321)5.14794397
25regulation of T cell tolerance induction (GO:0002664)5.11208222
26positive regulation by organism of defense response of other organism involved in symbiotic interact5.10545889
27modulation by symbiont of host immune response (GO:0052553)5.10545889
28positive regulation by symbiont of host defense response (GO:0052509)5.10545889
29modulation by symbiont of host defense response (GO:0052031)5.10545889
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10545889
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10545889
32mitochondrial respiratory chain complex assembly (GO:0033108)5.06344904
33positive regulation of gamma-delta T cell activation (GO:0046645)5.00471547
34positive T cell selection (GO:0043368)4.99970865
35membrane raft organization (GO:0031579)4.96167829
36thrombin receptor signaling pathway (GO:0070493)4.93841578
37respiratory electron transport chain (GO:0022904)4.92708874
38electron transport chain (GO:0022900)4.84515958
39sphingolipid catabolic process (GO:0030149)4.80387182
40T cell selection (GO:0045058)4.78034649
41T cell migration (GO:0072678)4.76685640
42positive regulation of megakaryocyte differentiation (GO:0045654)4.76377708
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.73925475
44ribosomal small subunit assembly (GO:0000028)4.72510378
45glycosphingolipid catabolic process (GO:0046479)4.71873940
46tolerance induction (GO:0002507)4.64225773
47viral transcription (GO:0019083)4.56440037
48regulation of alpha-beta T cell proliferation (GO:0046640)4.50326016
49translational termination (GO:0006415)4.48743740
50positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.43486781
51leukocyte aggregation (GO:0070486)4.41780108
52cellular response to exogenous dsRNA (GO:0071360)4.39145373
53membrane lipid catabolic process (GO:0046466)4.35372832
54pH reduction (GO:0045851)4.28894539
55proteasome assembly (GO:0043248)4.27179823
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26948391
57negative regulation of cell killing (GO:0031342)4.25351277
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25351277
59termination of RNA polymerase III transcription (GO:0006386)4.23591424
60transcription elongation from RNA polymerase III promoter (GO:0006385)4.23591424
61cotranslational protein targeting to membrane (GO:0006613)4.22133301
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.21926686
63T cell costimulation (GO:0031295)4.21072369
64glycolipid catabolic process (GO:0019377)4.20991471
65mast cell activation (GO:0045576)4.18971254
66protein targeting to ER (GO:0045047)4.15166136
67lymphocyte costimulation (GO:0031294)4.14098648
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12156796
69respiratory chain complex IV assembly (GO:0008535)4.10865354
70microglial cell activation (GO:0001774)4.07457042
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.06352606
72regulation of isotype switching to IgG isotypes (GO:0048302)3.96482404
73chromatin remodeling at centromere (GO:0031055)3.95324494
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95159958
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94213261
76ceramide catabolic process (GO:0046514)3.93314698
77protein localization to endoplasmic reticulum (GO:0070972)3.92719334
78maturation of SSU-rRNA (GO:0030490)3.92413692
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.90653460
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.90653460
81CENP-A containing nucleosome assembly (GO:0034080)3.87506692
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86721403
83T cell receptor signaling pathway (GO:0050852)3.86274304
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83488180
85positive regulation of antigen processing and presentation (GO:0002579)3.79902667
86translational elongation (GO:0006414)3.77657402
87cytochrome complex assembly (GO:0017004)3.76380213
88production of molecular mediator involved in inflammatory response (GO:0002532)3.76354273
89regulation of lymphocyte migration (GO:2000401)3.70541907
90regulation of T cell receptor signaling pathway (GO:0050856)3.69662632
91actin nucleation (GO:0045010)3.68245915
92regulation of tolerance induction (GO:0002643)3.66592286
93regulation of interferon-beta biosynthetic process (GO:0045357)3.65159738
94cellular extravasation (GO:0045123)3.63406562
95cellular response to interferon-beta (GO:0035458)3.63176646
96regulation of gamma-delta T cell differentiation (GO:0045586)3.61075198
97positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59316197
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59290677
99positive regulation of tolerance induction (GO:0002645)3.58027191
100regulation of gamma-delta T cell activation (GO:0046643)3.57326984
101ribosomal large subunit biogenesis (GO:0042273)3.55812166
102positive regulation of interferon-alpha production (GO:0032727)3.54993004
103negative regulation of osteoclast differentiation (GO:0045671)3.54008881
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53935870
105cellular response to interleukin-15 (GO:0071350)3.52086542
106platelet dense granule organization (GO:0060155)3.51836092
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51323529
108DNA deamination (GO:0045006)3.46777112
109regulation of interferon-alpha production (GO:0032647)3.46250651
110antigen receptor-mediated signaling pathway (GO:0050851)3.45168364
111hydrogen ion transmembrane transport (GO:1902600)3.43197797
112translation (GO:0006412)3.42824314
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42488425
114negative regulation of ligase activity (GO:0051352)3.42488425
115positive regulation of chemokine biosynthetic process (GO:0045080)3.41933343
116regulation of antigen processing and presentation (GO:0002577)3.40979381
117ribosomal small subunit biogenesis (GO:0042274)3.40009017
118Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39141050
119positive regulation of interleukin-8 secretion (GO:2000484)3.39014450
120viral life cycle (GO:0019058)3.38718912
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37406726
122inner mitochondrial membrane organization (GO:0007007)3.36537923
123positive regulation of T-helper 1 type immune response (GO:0002827)3.36276721
124cellular protein complex disassembly (GO:0043624)3.35730406
125regulation of mitochondrial translation (GO:0070129)3.32430225
126regulation of B cell differentiation (GO:0045577)3.30265666
127megakaryocyte development (GO:0035855)3.30062872
128response to interleukin-15 (GO:0070672)3.29770984
129positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29660535
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29265003
131negative regulation of T cell receptor signaling pathway (GO:0050860)3.27991372
132tyrosine phosphorylation of STAT protein (GO:0007260)3.26799673
133base-excision repair, AP site formation (GO:0006285)3.26296750
134cullin deneddylation (GO:0010388)3.24998016
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.24492474
136translational initiation (GO:0006413)3.23919332
137negative regulation of T cell mediated immunity (GO:0002710)3.23817517
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22205241
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22205241
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22205241
141ATP biosynthetic process (GO:0006754)3.21961875
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21564856
143regulation of cellular amino acid metabolic process (GO:0006521)3.21274509
144rRNA modification (GO:0000154)3.20038250
145negative regulation of B cell proliferation (GO:0030889)3.19057946
146protein deneddylation (GO:0000338)3.18795276
147signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17716566
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17716566
149positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.17697509
150protein-cofactor linkage (GO:0018065)3.14370409
151chemokine-mediated signaling pathway (GO:0070098)3.13555060
152purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13132910
153protein targeting to mitochondrion (GO:0006626)3.12741415
154proton transport (GO:0015992)3.11954176
155regulation of mitotic spindle checkpoint (GO:1903504)3.11535316
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11535316
157regulation of T cell mediated cytotoxicity (GO:0001914)3.10042555
158purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09983221
159antigen processing and presentation via MHC class Ib (GO:0002475)3.08727118
160pseudouridine synthesis (GO:0001522)3.08206234
161deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07389055
162positive regulation of interleukin-2 production (GO:0032743)3.07054794
163release of sequestered calcium ion into cytosol (GO:0051209)3.06996022
164negative regulation of sequestering of calcium ion (GO:0051283)3.06996022
165hydrogen transport (GO:0006818)3.05651710
166oligosaccharide catabolic process (GO:0009313)3.05558308
167cellular component biogenesis (GO:0044085)3.05409061
168response to host immune response (GO:0052572)3.05368880
169response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05368880
170signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05243886
171signal transduction involved in DNA damage checkpoint (GO:0072422)3.05243886
172sequestering of actin monomers (GO:0042989)3.04236601
173grooming behavior (GO:0007625)3.03906250
174positive regulation of interferon-gamma production (GO:0032729)3.03768375
175signal transduction involved in cell cycle checkpoint (GO:0072395)3.03657760
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02739765
177histone exchange (GO:0043486)3.02600934
178mannosylation (GO:0097502)3.02199225
179spliceosomal snRNP assembly (GO:0000387)3.02145423
180immunoglobulin mediated immune response (GO:0016064)3.01861962
181establishment of protein localization to mitochondrion (GO:0072655)3.01149254
182protein localization to mitochondrion (GO:0070585)3.00507952
183regulation of interleukin-2 biosynthetic process (GO:0045076)3.00452088
184negative regulation of type 2 immune response (GO:0002829)2.99331224
185pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98426935
186respiratory burst (GO:0045730)2.96491841
187intracellular protein transmembrane import (GO:0044743)2.96254195
188positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95267027
189oxidative phosphorylation (GO:0006119)2.91394512
190telomere maintenance via semi-conservative replication (GO:0032201)2.91294493
191deoxyribonucleotide catabolic process (GO:0009264)2.91159827
192transcription-coupled nucleotide-excision repair (GO:0006283)2.90831548
193DNA double-strand break processing (GO:0000729)2.90048145
194positive regulation of ligase activity (GO:0051351)2.86675799
195pyrimidine nucleotide catabolic process (GO:0006244)2.86410915
196histone mRNA metabolic process (GO:0008334)2.81850587
197deoxyribose phosphate catabolic process (GO:0046386)2.81787497
198peptidyl-histidine modification (GO:0018202)2.79742000
199replication fork processing (GO:0031297)2.74266963
200nuclear-transcribed mRNA catabolic process (GO:0000956)2.73643805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.78382545
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.41016319
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.16062627
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12137631
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.83725525
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.45015549
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.40207878
8EST1_17652178_ChIP-ChIP_JURKAT_Human4.37757523
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.03436587
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.73667548
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.72058613
12RUNX_20019798_ChIP-Seq_JUKART_Human3.61170858
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59461614
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.43116856
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38963608
16IRF8_27001747_Chip-Seq_BMDM_Mouse3.26596717
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25375421
18STAT4_19710469_ChIP-ChIP_TH1__Mouse3.25063224
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24138872
20MYB_26560356_Chip-Seq_TH2_Human3.13670112
21ETS1_20019798_ChIP-Seq_JURKAT_Human3.04730712
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.01115062
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99593225
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.99161511
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95556263
26ELK1_19687146_ChIP-ChIP_HELA_Human2.95530497
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88524587
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87627879
29E2F7_22180533_ChIP-Seq_HELA_Human2.86002608
30VDR_23849224_ChIP-Seq_CD4+_Human2.80562900
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73420928
32MAF_26560356_Chip-Seq_TH1_Human2.63042346
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62458402
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57229041
35FOXP3_21729870_ChIP-Seq_TREG_Human2.53005996
36MYC_18555785_ChIP-Seq_MESCs_Mouse2.52373824
37MYB_26560356_Chip-Seq_TH1_Human2.47532416
38SCL_19346495_ChIP-Seq_HPC-7_Human2.41787355
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29419057
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23848465
41SRF_21415370_ChIP-Seq_HL-1_Mouse2.20854007
42RUNX1_22412390_ChIP-Seq_EML_Mouse2.16649203
43* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16522824
44* UTX_26944678_Chip-Seq_JUKART_Human2.13545336
45VDR_22108803_ChIP-Seq_LS180_Human2.09913215
46* GATA3_27048872_Chip-Seq_THYMUS_Human2.05283577
47ZNF274_21170338_ChIP-Seq_K562_Hela2.02749502
48MYC_22102868_ChIP-Seq_BL_Human2.01101032
49* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00387103
50MYC_18940864_ChIP-ChIP_HL60_Human1.99369069
51SPI1_23547873_ChIP-Seq_NB4_Human1.95662518
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93235359
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92747539
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89416358
55* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88526601
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88426668
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86828909
58SPI1_23127762_ChIP-Seq_K562_Human1.86400437
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83809877
60* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82186556
61EWS_26573619_Chip-Seq_HEK293_Human1.79193814
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78037660
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77519429
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74896720
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73636846
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73496873
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72321222
68DCP1A_22483619_ChIP-Seq_HELA_Human1.72262753
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71507850
70TTF2_22483619_ChIP-Seq_HELA_Human1.69682280
71MAF_26560356_Chip-Seq_TH2_Human1.67593448
72TCF7_22412390_ChIP-Seq_EML_Mouse1.66268646
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66029865
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62219830
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61083762
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60862686
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.60009174
78FUS_26573619_Chip-Seq_HEK293_Human1.57146256
79* GABP_19822575_ChIP-Seq_HepG2_Human1.56364591
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48541651
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.47762250
82XRN2_22483619_ChIP-Seq_HELA_Human1.42922020
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42461524
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.40317545
85* PU_27001747_Chip-Seq_BMDM_Mouse1.38257960
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36494357
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32897457
88VDR_24763502_ChIP-Seq_THP-1_Human1.31768296
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30989397
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.30756805
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.30668911
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29669239
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28835163
94* GATA3_26560356_Chip-Seq_TH2_Human1.28823874
95IRF1_19129219_ChIP-ChIP_H3396_Human1.28101381
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27998728
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27792857
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27688283
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23381057
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22522427
101VDR_21846776_ChIP-Seq_THP-1_Human1.20565251
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20427942
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20329333
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20215779
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19448750
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18521702
107VDR_24787735_ChIP-Seq_THP-1_Human1.17711526
108TP53_22573176_ChIP-Seq_HFKS_Human1.17334925
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17150960
110* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16946179
111SMAD_19615063_ChIP-ChIP_OVARY_Human1.16378692
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15809384
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15086157
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13831356
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13028290
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13025479
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09821399
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09671277
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09066905
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07046496
121TAF15_26573619_Chip-Seq_HEK293_Human1.06485666
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06285604
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.05293026
124P300_19829295_ChIP-Seq_ESCs_Human1.05154084
125ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04838801
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04367232
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03430605
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03184424
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03122066
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02990024
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02304762
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00808229
133FOXA1_25329375_ChIP-Seq_VCAP_Human1.00808229
134IGF1R_20145208_ChIP-Seq_DFB_Human0.99921770
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99381575
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.99243421
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98999483
138EGR1_19032775_ChIP-ChIP_M12_Human0.98652151
139* KDM2B_26808549_Chip-Seq_DND41_Human0.95814108
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95670194
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.94340824
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93116077
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93034776
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92666747
145AR_20517297_ChIP-Seq_VCAP_Human0.90632763
146TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90227958
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89825704
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89680494
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89035059
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88617122
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88607339
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88402411
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86760643
154NANOG_19829295_ChIP-Seq_ESCs_Human0.86043232
155SOX2_19829295_ChIP-Seq_ESCs_Human0.86043232
156CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85383273
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85204883
158ER_23166858_ChIP-Seq_MCF-7_Human0.84394481
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83958823
160KDM5A_27292631_Chip-Seq_BREAST_Human0.83891173
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83651296
162ERG_20517297_ChIP-Seq_VCAP_Human0.83123878
163* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82805922
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82710165
165FOXM1_23109430_ChIP-Seq_U2OS_Human0.82486463
166NANOG_16153702_ChIP-ChIP_HESCs_Human0.82312050
167RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81285906
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.81129982
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81022949
170FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80513184
171PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80207260
172TP63_19390658_ChIP-ChIP_HaCaT_Human0.79716541
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75738651
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75056246
175SMRT_27268052_Chip-Seq_Bcells_Human0.74369268
176RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73997628
177FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72715030
178GATA1_22025678_ChIP-Seq_K562_Human0.71888955
179CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.71869241
180TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69664172
181GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69282941
182SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68246712
183FOXO3_23340844_ChIP-Seq_DLD1_Human0.67167421
184NFE2_27457419_Chip-Seq_LIVER_Mouse0.66201782
185STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65431482
186* P300_27268052_Chip-Seq_Bcells_Human0.61843122
187SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61649273
188ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61127343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.19536904
2MP0005671_abnormal_response_to4.95726700
3MP0006082_CNS_inflammation4.37410587
4MP0009379_abnormal_foot_pigmentation3.58441789
5MP0003763_abnormal_thymus_physiology3.51064922
6MP0006292_abnormal_olfactory_placode3.12056620
7MP0005387_immune_system_phenotype3.06515519
8MP0001790_abnormal_immune_system3.06515519
9MP0000685_abnormal_immune_system3.05072755
10MP0002166_altered_tumor_susceptibility2.95492490
11MP0008058_abnormal_DNA_repair2.93995875
12MP0003806_abnormal_nucleotide_metabolis2.89623249
13MP0001800_abnormal_humoral_immune2.89605824
14MP0000372_irregular_coat_pigmentation2.84307224
15MP0001819_abnormal_immune_cell2.82554346
16MP0003136_yellow_coat_color2.79986907
17MP0009333_abnormal_splenocyte_physiolog2.78067411
18MP0002452_abnormal_antigen_presenting2.77932397
19MP0005000_abnormal_immune_tolerance2.71947010
20MP0002006_tumorigenesis2.70362158
21MP0009785_altered_susceptibility_to2.68379845
22MP0002420_abnormal_adaptive_immunity2.67389979
23MP0002148_abnormal_hypersensitivity_rea2.62978714
24MP0002723_abnormal_immune_serum2.58223597
25MP0002102_abnormal_ear_morphology2.55914306
26MP0005025_abnormal_response_to2.53633942
27MP0010094_abnormal_chromosome_stability2.45191901
28MP0003186_abnormal_redox_activity2.38450542
29MP0002398_abnormal_bone_marrow2.35109840
30MP0002405_respiratory_system_inflammati2.34942998
31MP0003436_decreased_susceptibility_to2.33315677
32MP0003693_abnormal_embryo_hatching2.32296476
33MP0004510_myositis2.25028220
34MP0003718_maternal_effect2.19729281
35MP0005464_abnormal_platelet_physiology2.18144573
36MP0006036_abnormal_mitochondrial_physio2.16423076
37MP0002419_abnormal_innate_immunity2.13878375
38* MP0000716_abnormal_immune_system2.08586732
39MP0001853_heart_inflammation2.08506395
40MP0002938_white_spotting2.06304151
41MP0004147_increased_porphyrin_level2.02606697
42MP0008789_abnormal_olfactory_epithelium2.02161739
43MP0001529_abnormal_vocalization1.98578670
44MP0010155_abnormal_intestine_physiology1.96802942
45MP0005084_abnormal_gallbladder_morpholo1.95395411
46MP0006072_abnormal_retinal_apoptosis1.91646134
47MP0002653_abnormal_ependyma_morphology1.89903172
48MP0002722_abnormal_immune_system1.87755761
49MP0000689_abnormal_spleen_morphology1.86889582
50MP0005410_abnormal_fertilization1.86162636
51MP0003300_gastrointestinal_ulcer1.85111283
52MP0003011_delayed_dark_adaptation1.82915834
53MP0003866_abnormal_defecation1.82434289
54MP0000703_abnormal_thymus_morphology1.80892967
55MP0002277_abnormal_respiratory_mucosa1.80422166
56MP0002638_abnormal_pupillary_reflex1.79928781
57MP0006035_abnormal_mitochondrial_morpho1.78698167
58MP0001485_abnormal_pinna_reflex1.76363845
59MP0002736_abnormal_nociception_after1.76363388
60MP0004947_skin_inflammation1.76250991
61MP0002095_abnormal_skin_pigmentation1.70739128
62MP0003786_premature_aging1.68590236
63* MP0002429_abnormal_blood_cell1.67141787
64MP0004142_abnormal_muscle_tone1.67043990
65MP0001873_stomach_inflammation1.62168300
66MP0005310_abnormal_salivary_gland1.61016908
67MP0001845_abnormal_inflammatory_respons1.57772510
68MP0003724_increased_susceptibility_to1.55941483
69MP0001293_anophthalmia1.54747628
70MP0000569_abnormal_digit_pigmentation1.52374599
71MP0005551_abnormal_eye_electrophysiolog1.44444895
72MP0003077_abnormal_cell_cycle1.44428948
73MP0002163_abnormal_gland_morphology1.42556564
74MP0004957_abnormal_blastocyst_morpholog1.42437867
75MP0002160_abnormal_reproductive_system1.36164891
76MP0005253_abnormal_eye_physiology1.34560853
77MP0000858_altered_metastatic_potential1.33438886
78MP0008932_abnormal_embryonic_tissue1.31868573
79MP0005499_abnormal_olfactory_system1.31118096
80MP0005394_taste/olfaction_phenotype1.31118096
81MP0001968_abnormal_touch/_nociception1.29819196
82MP0002234_abnormal_pharynx_morphology1.29149856
83MP0002396_abnormal_hematopoietic_system1.28137805
84MP0003880_abnormal_central_pattern1.24771359
85MP0003195_calcinosis1.24198719
86MP0005389_reproductive_system_phenotype1.22752337
87MP0005379_endocrine/exocrine_gland_phen1.19905671
88MP0000490_abnormal_crypts_of1.19337118
89MP0004808_abnormal_hematopoietic_stem1.18507329
90MP0005075_abnormal_melanosome_morpholog1.17487443
91MP0000343_altered_response_to1.17436253
92MP0001905_abnormal_dopamine_level1.15485582
93MP0003448_altered_tumor_morphology1.14489091
94MP0009697_abnormal_copulation1.14235230
95MP0003111_abnormal_nucleus_morphology1.14071489
96MP0001984_abnormal_olfaction1.13607337
97MP0003566_abnormal_cell_adhesion1.13576813
98MP0010352_gastrointestinal_tract_polyps1.13553315
99MP0005408_hypopigmentation1.13102641
100MP0008469_abnormal_protein_level1.13081710
101MP0001986_abnormal_taste_sensitivity1.12772729
102MP0000465_gastrointestinal_hemorrhage1.11799313
103MP0005397_hematopoietic_system_phenotyp1.11633665
104MP0001545_abnormal_hematopoietic_system1.11633665
105MP0008057_abnormal_DNA_replication1.11380467
106MP0000631_abnormal_neuroendocrine_gland1.09999022
107MP0008872_abnormal_physiological_respon1.09412619
108MP0002933_joint_inflammation1.08228139
109MP0003303_peritoneal_inflammation1.07241242
110MP0008875_abnormal_xenobiotic_pharmacok1.05458530
111MP0002210_abnormal_sex_determination1.05160026
112MP0000516_abnormal_urinary_system1.04162365
113MP0005367_renal/urinary_system_phenotyp1.04162365
114MP0008007_abnormal_cellular_replicative1.03504927
115MP0002876_abnormal_thyroid_physiology1.03462012
116MP0002877_abnormal_melanocyte_morpholog1.02944022
117MP0005646_abnormal_pituitary_gland1.02494160
118MP0003172_abnormal_lysosome_physiology1.02061857
119MP0001764_abnormal_homeostasis1.00846810
120MP0009764_decreased_sensitivity_to1.00165776
121MP0008995_early_reproductive_senescence0.99522857
122MP0002090_abnormal_vision0.97562151
123MP0000049_abnormal_middle_ear0.97085579
124MP0005076_abnormal_cell_differentiation0.96979356
125MP0000015_abnormal_ear_pigmentation0.94151153
126MP0002009_preneoplasia0.92826313
127MP0001533_abnormal_skeleton_physiology0.91243850
128MP0010234_abnormal_vibrissa_follicle0.90448241
129MP0001919_abnormal_reproductive_system0.89562236
130MP0002837_dystrophic_cardiac_calcinosis0.87204136
131MP0002751_abnormal_autonomic_nervous0.86985026
132MP0000653_abnormal_sex_gland0.85797590
133MP0001145_abnormal_male_reproductive0.85369946
134MP0000383_abnormal_hair_follicle0.84763865
135MP0001119_abnormal_female_reproductive0.84705175
136MP0003646_muscle_fatigue0.83340813
137MP0006276_abnormal_autonomic_nervous0.82112927
138MP0003045_fibrosis0.80621673
139MP0002998_abnormal_bone_remodeling0.80465018
140MP0001324_abnormal_eye_pigmentation0.79265805
141MP0003787_abnormal_imprinting0.79226880
142MP0005670_abnormal_white_adipose0.79191553
143MP0005195_abnormal_posterior_eye0.77702838
144MP0004742_abnormal_vestibular_system0.76693191
145MP0005058_abnormal_lysosome_morphology0.76146275
146MP0001286_abnormal_eye_development0.75833017
147MP0009763_increased_sensitivity_to0.75616216
148MP0001851_eye_inflammation0.75427409
149MP0003315_abnormal_perineum_morphology0.75120336
150MP0003878_abnormal_ear_physiology0.74670148
151MP0005377_hearing/vestibular/ear_phenot0.74670148
152MP0000358_abnormal_cell_content/0.74558582
153MP0004145_abnormal_muscle_electrophysio0.73987218
154MP0004381_abnormal_hair_follicle0.73851997
155MP0003183_abnormal_peptide_metabolism0.73437185
156MP0002282_abnormal_trachea_morphology0.69254600
157MP0000026_abnormal_inner_ear0.69097590
158MP0002928_abnormal_bile_duct0.68794497
159MP0005266_abnormal_metabolism0.67867078
160MP0003943_abnormal_hepatobiliary_system0.67568272
161MP0005391_vision/eye_phenotype0.67484094
162MP0002233_abnormal_nose_morphology0.67044993
163MP0008877_abnormal_DNA_methylation0.66984527
164MP0009765_abnormal_xenobiotic_induced0.66252206
165MP0002019_abnormal_tumor_incidence0.65897793
166MP0000249_abnormal_blood_vessel0.65462318
167MP0003638_abnormal_response/metabolism_0.56366733
168MP0005174_abnormal_tail_pigmentation0.56088409
169MP0001216_abnormal_epidermal_layer0.54904647
170MP0001929_abnormal_gametogenesis0.53386100
171MP0010678_abnormal_skin_adnexa0.53132434
172MP0000477_abnormal_intestine_morphology0.49332326
173MP0003941_abnormal_skin_development0.49211588
174MP0002136_abnormal_kidney_physiology0.48863365
175MP0000371_diluted_coat_color0.48678704
176MP0000609_abnormal_liver_physiology0.47226502
177MP0000367_abnormal_coat/_hair0.45607393
178MP0005166_decreased_susceptibility_to0.44113191
179MP0009046_muscle_twitch0.43279441
180MP0005623_abnormal_meninges_morphology0.43199942
181MP0003795_abnormal_bone_structure0.42406121
182MP0008770_decreased_survivor_rate0.42156948
183MP0000598_abnormal_liver_morphology0.41952857
184MP0003453_abnormal_keratinocyte_physiol0.38345188
185MP0005023_abnormal_wound_healing0.37088196

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)8.07707121
2Increased cerebral lipofuscin (HP:0011813)7.25096108
3Loss of speech (HP:0002371)5.82813309
4Acute necrotizing encephalopathy (HP:0006965)5.37762368
5Nasal polyposis (HP:0100582)5.11708556
6Mitochondrial inheritance (HP:0001427)4.96079496
7Chronic otitis media (HP:0000389)4.92546393
8Abnormal mitochondria in muscle tissue (HP:0008316)4.84334201
9Acute encephalopathy (HP:0006846)4.71400331
10Obstructive lung disease (HP:0006536)4.70083783
11Chronic obstructive pulmonary disease (HP:0006510)4.70083783
12Recurrent bronchitis (HP:0002837)4.54271785
13Progressive macrocephaly (HP:0004481)4.49920865
14T lymphocytopenia (HP:0005403)4.48802564
15IgM deficiency (HP:0002850)4.46955215
16Increased CSF lactate (HP:0002490)4.33722601
17Abnormality of T cell number (HP:0011839)4.29551592
18Hepatocellular necrosis (HP:0001404)4.23561746
19Abnormality of the nasal mucosa (HP:0000433)4.19027978
20Increased hepatocellular lipid droplets (HP:0006565)4.05347910
21Abolished electroretinogram (ERG) (HP:0000550)4.03246322
22Abnormality of liposaccharide metabolism (HP:0010968)3.90660184
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.90660184
24Abnormality of glycolipid metabolism (HP:0010969)3.90660184
25Hepatic necrosis (HP:0002605)3.88022441
26Lipid accumulation in hepatocytes (HP:0006561)3.82992534
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.78301123
28Hemoptysis (HP:0002105)3.78035785
293-Methylglutaconic aciduria (HP:0003535)3.76793194
30Elevated erythrocyte sedimentation rate (HP:0003565)3.71080546
31Acrocyanosis (HP:0001063)3.64644821
32Myositis (HP:0100614)3.63136560
33Optic neuritis (HP:0100653)3.62867675
34Retrobulbar optic neuritis (HP:0100654)3.62867675
35Cerebral palsy (HP:0100021)3.60947203
36Vasculitis (HP:0002633)3.57468878
37Renal Fanconi syndrome (HP:0001994)3.53812975
38Testicular atrophy (HP:0000029)3.49601546
39Abnormal number of erythroid precursors (HP:0012131)3.46933924
40Recurrent sinusitis (HP:0011108)3.44577429
41IgG deficiency (HP:0004315)3.41842215
42Reticulocytopenia (HP:0001896)3.39296058
43Abnormality of cells of the erythroid lineage (HP:0012130)3.37631640
44Abnormality of the pleura (HP:0002103)3.36487149
45Pancreatic cysts (HP:0001737)3.36361037
46Recurrent abscess formation (HP:0002722)3.30666639
47Cerebral edema (HP:0002181)3.28445414
48Autoimmune hemolytic anemia (HP:0001890)3.25276470
49Meningitis (HP:0001287)3.24253676
50Eczematoid dermatitis (HP:0000976)3.20490464
51Recurrent viral infections (HP:0004429)3.19816531
52Molar tooth sign on MRI (HP:0002419)3.16585113
53Abnormality of midbrain morphology (HP:0002418)3.16585113
54Recurrent fungal infections (HP:0002841)3.14894505
55Abnormality of T cells (HP:0002843)3.13465032
56Pancreatic fibrosis (HP:0100732)3.12308802
57Orchitis (HP:0100796)3.09152437
58Bronchitis (HP:0012387)3.05821168
59Pulmonary infiltrates (HP:0002113)3.04492469
60True hermaphroditism (HP:0010459)3.00338264
61Macular degeneration (HP:0000608)2.99441073
62Stomatitis (HP:0010280)2.95410830
63Combined immunodeficiency (HP:0005387)2.95320254
64Abnormality of the pericardium (HP:0001697)2.92888687
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91810524
66Exertional dyspnea (HP:0002875)2.89416261
67Increased intramyocellular lipid droplets (HP:0012240)2.89234774
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88962585
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88962585
70Lactic acidosis (HP:0003128)2.87431171
71Severe combined immunodeficiency (HP:0004430)2.85324640
72Congenital, generalized hypertrichosis (HP:0004540)2.83454243
73Macrocytic anemia (HP:0001972)2.81800707
74Increased serum lactate (HP:0002151)2.79588126
75Abnormality of eosinophils (HP:0001879)2.76713477
76Optic disc pallor (HP:0000543)2.74325225
77Type I transferrin isoform profile (HP:0003642)2.71806069
78IgA deficiency (HP:0002720)2.68810460
79Arterial thrombosis (HP:0004420)2.68767182
80Abnormality of the fingertips (HP:0001211)2.66972262
81Progressive microcephaly (HP:0000253)2.66072068
82Respiratory failure (HP:0002878)2.65845428
83Emphysema (HP:0002097)2.64335023
84Glomerulopathy (HP:0100820)2.60357255
85Recurrent bacterial skin infections (HP:0005406)2.59039047
86Abnormality of the prostate (HP:0008775)2.59003306
87Abnormal platelet volume (HP:0011876)2.58759700
88Pulmonary fibrosis (HP:0002206)2.56898380
89Aplastic anemia (HP:0001915)2.56565498
90Absent thumb (HP:0009777)2.53393258
91Azoospermia (HP:0000027)2.52530505
92Keratoconjunctivitis sicca (HP:0001097)2.50646837
93Chronic sinusitis (HP:0011109)2.49397928
94Joint swelling (HP:0001386)2.47389729
95Lymphoma (HP:0002665)2.46550848
96Bronchiectasis (HP:0002110)2.44357130
97Exercise intolerance (HP:0003546)2.42555840
98Chronic diarrhea (HP:0002028)2.42178563
99Pustule (HP:0200039)2.42115263
100Anorexia (HP:0002039)2.42081534
101Increased mean platelet volume (HP:0011877)2.41953819
102Abnormal spermatogenesis (HP:0008669)2.41936617
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.41891611
104Increased muscle lipid content (HP:0009058)2.41822818
105Methylmalonic acidemia (HP:0002912)2.41441478
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40043075
107Recurrent otitis media (HP:0000403)2.39565789
108Lymphopenia (HP:0001888)2.39003217
109Eosinophilia (HP:0001880)2.38057248
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38008949
111Abnormal protein glycosylation (HP:0012346)2.37383666
112Abnormal glycosylation (HP:0012345)2.37383666
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37383666
114Abnormal protein N-linked glycosylation (HP:0012347)2.37383666
115Gingival bleeding (HP:0000225)2.36030626
116Thyroiditis (HP:0100646)2.35058260
117Gastrointestinal infarctions (HP:0005244)2.34655739
118Leukodystrophy (HP:0002415)2.34527943
119Respiratory difficulties (HP:0002880)2.34444813
120Increased IgE level (HP:0003212)2.34033287
121Petechiae (HP:0000967)2.33938465
122Meckel diverticulum (HP:0002245)2.33015403
123Skin rash (HP:0000988)2.31854238
124Mediastinal lymphadenopathy (HP:0100721)2.29828741
125Abnormality of the ileum (HP:0001549)2.27196951
126Abnormality of complement system (HP:0005339)2.26937355
127Restrictive lung disease (HP:0002091)2.25962679
128Abnormality of cells of the lymphoid lineage (HP:0012140)2.25879558
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25629532
130Abnormality of alanine metabolism (HP:0010916)2.25629532
131Hyperalaninemia (HP:0003348)2.25629532
132Recurrent cutaneous fungal infections (HP:0011370)2.25455192
133Chronic mucocutaneous candidiasis (HP:0002728)2.25455192
134Methylmalonic aciduria (HP:0012120)2.25282408
135Abnormality of renal resorption (HP:0011038)2.24975746
136Medial flaring of the eyebrow (HP:0010747)2.24369757
137Encephalitis (HP:0002383)2.23672750
138Sclerocornea (HP:0000647)2.21600881
139Keratoconjunctivitis (HP:0001096)2.21437248
140Poor head control (HP:0002421)2.20325036
141Increased IgM level (HP:0003496)2.20254033
142Leukocytosis (HP:0001974)2.18017886
143Colon cancer (HP:0003003)2.18001662
144Gangrene (HP:0100758)2.13570315
145Lethargy (HP:0001254)2.13478436
146Progressive visual loss (HP:0000529)2.13346446
147Congenital stationary night blindness (HP:0007642)2.13133978
148Nephronophthisis (HP:0000090)2.12809247
149Thrombocytosis (HP:0001894)2.12012221
150Trigonocephaly (HP:0000243)2.09734763
151Pulmonary embolism (HP:0002204)2.09228517
152Prolonged bleeding time (HP:0003010)2.05172925
153Granulocytopenia (HP:0001913)2.04218277
154Abnormality of B cell number (HP:0010975)2.03921538
155B lymphocytopenia (HP:0010976)2.03921538
156Glycosuria (HP:0003076)2.03715945
157Abnormality of urine glucose concentration (HP:0011016)2.03715945
158Inflammation of the large intestine (HP:0002037)2.03226120
159CNS demyelination (HP:0007305)2.03050677
160Polyneuropathy (HP:0001271)2.02554688
161Recurrent skin infections (HP:0001581)2.02328527
162Pancytopenia (HP:0001876)2.01452799
163Generalized aminoaciduria (HP:0002909)2.00448009
164Pallor (HP:0000980)1.99327725
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98068701
166Septo-optic dysplasia (HP:0100842)1.93854131
167Reduced antithrombin III activity (HP:0001976)1.92992749
168Triphalangeal thumb (HP:0001199)1.91094400
169Male pseudohermaphroditism (HP:0000037)1.90636027
170Oral leukoplakia (HP:0002745)1.89086548
171Abnormality of chromosome stability (HP:0003220)1.88452094
172Abnormality of the preputium (HP:0100587)1.87785954
173Pendular nystagmus (HP:0012043)1.87417505
174Renal cortical cysts (HP:0000803)1.85567427
175Bile duct proliferation (HP:0001408)1.83517188
176Abnormal biliary tract physiology (HP:0012439)1.83517188
177Abnormality of the pons (HP:0007361)1.81051897
178Type II lissencephaly (HP:0007260)1.80341330
179Anencephaly (HP:0002323)1.77602799
180Aplasia/Hypoplasia of the tongue (HP:0010295)1.76447134
181Stenosis of the external auditory canal (HP:0000402)1.75947049
182Abnormality of the renal cortex (HP:0011035)1.75158625
183Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74628481
184Cleft eyelid (HP:0000625)1.71994740
185X-linked dominant inheritance (HP:0001423)1.70853208
186Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70794275
187Abnormality of the renal medulla (HP:0100957)1.70090262
188Hypoplasia of the pons (HP:0012110)1.69860627
189Hyperglycinemia (HP:0002154)1.68347795
190Congenital primary aphakia (HP:0007707)1.66492865
191Small intestinal stenosis (HP:0012848)1.66333750
192Duodenal stenosis (HP:0100867)1.66333750
193Abnormality of serum amino acid levels (HP:0003112)1.62463724
194Dicarboxylic aciduria (HP:0003215)1.61371219
195Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61371219
196Postaxial foot polydactyly (HP:0001830)1.58533714
197Blindness (HP:0000618)1.58209459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.63351303
2TXK6.21634533
3VRK24.87325969
4ITK3.83159127
5ZAK3.62204011
6BUB13.03591633
7TYK22.88851775
8STK162.78987624
9FGFR42.77968854
10KIT2.73406686
11MAP3K122.61601028
12JAK12.32492538
13ZAP702.31610622
14MAP4K22.21928650
15TLK12.20436978
16STK102.05894349
17SYK2.05005413
18BMPR1B2.04704592
19FGFR32.01712547
20WNK32.00428172
21CDC72.00161533
22JAK31.99675934
23TBK11.98289278
24CSF1R1.97338870
25IKBKE1.93118427
26ADRBK21.91667683
27NEK11.85032552
28MAP3K141.81648891
29IRAK41.73664879
30WEE11.71924931
31EIF2AK31.68351301
32BCKDK1.65266985
33PLK41.63546779
34CSK1.62014335
35SRPK11.53726150
36EEF2K1.53435358
37TEC1.51874147
38TRIM281.51503327
39LCK1.48472373
40PLK31.47604939
41NUAK11.45489339
42NME11.44203266
43TSSK61.42815831
44PBK1.35834334
45TAF11.33648345
46DYRK21.29641703
47PRKCQ1.29062422
48IKBKB1.28568173
49INSRR1.27532623
50MST41.26648827
51HCK1.25920096
52TAOK31.25568766
53LYN1.20824148
54BLK1.10308288
55MUSK1.05398437
56CCNB11.05367063
57CHEK21.00828629
58BTK1.00743807
59PIM11.00050018
60BRSK20.98711174
61CSNK1G30.98278535
62GRK60.95701614
63PLK10.95627741
64GRK10.95356362
65TTK0.95154384
66MKNK20.92924470
67MKNK10.90216593
68CDK80.89875568
69PDK10.88848217
70CSNK1G20.86658214
71OXSR10.86105570
72MARK30.84132881
73ATR0.83520471
74RPS6KA50.82764746
75STK240.81554084
76EPHB10.81342862
77JAK20.80467355
78NLK0.79330174
79MAP2K60.78342842
80TRPM70.78042289
81PINK10.77665822
82TAOK20.77185964
83EIF2AK20.76835704
84ACVR1B0.76763003
85LRRK20.75581513
86AURKB0.72497990
87TGFBR20.71791078
88ERBB30.71633695
89MAPK130.70879757
90DYRK30.70869066
91PDK30.70416388
92PDK40.70416388
93MAPK150.69986973
94GRK70.69521105
95PRKCH0.68970307
96MYLK0.68946733
97CSNK1A1L0.67475820
98FLT30.67167524
99TNIK0.66346750
100ABL20.64863960
101NEK20.63846212
102NEK90.63249323
103TESK20.61760681
104CSNK2A10.61483194
105FGFR20.61259158
106CAMKK20.61216836
107PLK20.60518435
108LIMK10.60174509
109MAP2K70.57586161
110MAP3K40.55987388
111TESK10.54194974
112KDR0.53460925
113MELK0.53129787
114ADRBK10.52784772
115IRAK30.52603069
116MAPK110.52057189
117STK30.51775420
118GRK50.51511524
119CDK120.50298874
120DAPK30.49935872
121AURKA0.49495864
122CSNK2A20.48830922
123CHUK0.47844112
124FES0.47632621
125CDK30.47582226
126EIF2AK10.47412123
127PRKCG0.46463225
128CLK10.45462243
129PIK3CG0.45388205
130BRSK10.45111415
131PRKCD0.43689526
132RPS6KB20.42757220
133MATK0.42211704
134TIE10.42127354
135CDK40.41918335
136PNCK0.41197276
137DYRK1B0.39471011
138MAPKAPK20.39152611
139RPS6KA40.38270258
140PRKD20.38023791
141STK110.37872627
142IGF1R0.37704427
143TGFBR10.37484302
144PASK0.37292344
145CSNK1A10.35226480
146WNK40.35179843
147STK390.34237536
148SCYL20.33379548
149PRKCE0.33185128
150MAP3K80.32789524
151CDK60.32598864
152EPHA30.32554917
153CSNK1G10.31041807
154OBSCN0.30344142
155BCR0.29926642
156NTRK20.28667252
157PDK20.27983782
158FYN0.26829532
159MAPKAPK50.26824947
160MAP3K70.26061970
161ALK0.24968885
162SIK30.24919799
163CDK190.24353913
164TAOK10.24238803
165RIPK40.22030955
166MAP3K50.20806855
167MAPK70.20269251
168TNK20.19904084
169NME20.19423694
170PAK40.19366305
171INSR0.17388191
172MAP3K130.17349839
173STK40.16802017
174VRK10.15888741
175MAPK30.15578600
176FRK0.15352609

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.63572050
2Oxidative phosphorylation_Homo sapiens_hsa001904.50334731
3Ribosome_Homo sapiens_hsa030104.29089775
4Parkinsons disease_Homo sapiens_hsa050123.81293082
5Graft-versus-host disease_Homo sapiens_hsa053323.70482756
6Antigen processing and presentation_Homo sapiens_hsa046123.41113246
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.37570026
8T cell receptor signaling pathway_Homo sapiens_hsa046603.27247797
9RNA polymerase_Homo sapiens_hsa030203.21635885
10Protein export_Homo sapiens_hsa030602.95653980
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.89598909
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.84062068
13Homologous recombination_Homo sapiens_hsa034402.78928466
14Huntingtons disease_Homo sapiens_hsa050162.73181454
15Fatty acid elongation_Homo sapiens_hsa000622.61952827
16Measles_Homo sapiens_hsa051622.60086826
17Mismatch repair_Homo sapiens_hsa034302.55185286
18Allograft rejection_Homo sapiens_hsa053302.52551674
19Alzheimers disease_Homo sapiens_hsa050102.51092464
20Hematopoietic cell lineage_Homo sapiens_hsa046402.34129109
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26704942
22Leishmaniasis_Homo sapiens_hsa051401.96341840
23Fanconi anemia pathway_Homo sapiens_hsa034601.95427057
24Autoimmune thyroid disease_Homo sapiens_hsa053201.91497086
25Osteoclast differentiation_Homo sapiens_hsa043801.88505913
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.87514196
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84586882
28B cell receptor signaling pathway_Homo sapiens_hsa046621.84327556
29Nucleotide excision repair_Homo sapiens_hsa034201.82221150
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77185802
31Viral myocarditis_Homo sapiens_hsa054161.76873117
32Pyrimidine metabolism_Homo sapiens_hsa002401.75408454
33Chemokine signaling pathway_Homo sapiens_hsa040621.71777341
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70573075
35Toxoplasmosis_Homo sapiens_hsa051451.69854939
36Cardiac muscle contraction_Homo sapiens_hsa042601.65705815
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64976632
38Herpes simplex infection_Homo sapiens_hsa051681.64762544
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57954812
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.56771243
41Fatty acid metabolism_Homo sapiens_hsa012121.49554611
42Influenza A_Homo sapiens_hsa051641.48884848
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45325303
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.42487899
45Lysosome_Homo sapiens_hsa041421.42473135
46One carbon pool by folate_Homo sapiens_hsa006701.42344782
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41938150
48Shigellosis_Homo sapiens_hsa051311.40837605
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33336699
50Sulfur metabolism_Homo sapiens_hsa009201.28830954
51Purine metabolism_Homo sapiens_hsa002301.27815898
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24712200
53Platelet activation_Homo sapiens_hsa046111.21647997
54Salmonella infection_Homo sapiens_hsa051321.20030346
55Renin-angiotensin system_Homo sapiens_hsa046141.17887770
56Non-homologous end-joining_Homo sapiens_hsa034501.15470260
57Propanoate metabolism_Homo sapiens_hsa006401.13951825
58Hepatitis B_Homo sapiens_hsa051611.11075421
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10503694
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08252397
61RNA transport_Homo sapiens_hsa030131.08210657
62Legionellosis_Homo sapiens_hsa051341.02480082
63Folate biosynthesis_Homo sapiens_hsa007901.02472438
64Staphylococcus aureus infection_Homo sapiens_hsa051501.01738542
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00091266
66Apoptosis_Homo sapiens_hsa042100.99638574
67Phototransduction_Homo sapiens_hsa047440.99053101
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98960307
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.98637499
70Epstein-Barr virus infection_Homo sapiens_hsa051690.96676909
71Type I diabetes mellitus_Homo sapiens_hsa049400.95507914
72Glutathione metabolism_Homo sapiens_hsa004800.95406957
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94807233
74Butanoate metabolism_Homo sapiens_hsa006500.93082453
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89704734
76Collecting duct acid secretion_Homo sapiens_hsa049660.87700926
77Nitrogen metabolism_Homo sapiens_hsa009100.86739187
78Tuberculosis_Homo sapiens_hsa051520.86720516
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85132995
80TNF signaling pathway_Homo sapiens_hsa046680.82661136
81Sulfur relay system_Homo sapiens_hsa041220.82366223
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.81665403
83Vitamin B6 metabolism_Homo sapiens_hsa007500.80396477
84* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79357869
85Peroxisome_Homo sapiens_hsa041460.79094697
86Metabolic pathways_Homo sapiens_hsa011000.78986421
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.78571685
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77320302
89Inositol phosphate metabolism_Homo sapiens_hsa005620.75957287
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75866440
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75615518
92Selenocompound metabolism_Homo sapiens_hsa004500.74829008
93Malaria_Homo sapiens_hsa051440.74052633
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71402939
95Systemic lupus erythematosus_Homo sapiens_hsa053220.71272018
96HTLV-I infection_Homo sapiens_hsa051660.71248592
97Viral carcinogenesis_Homo sapiens_hsa052030.70856204
98Caffeine metabolism_Homo sapiens_hsa002320.69261546
99Tryptophan metabolism_Homo sapiens_hsa003800.69259840
100Hepatitis C_Homo sapiens_hsa051600.68332201
101Chemical carcinogenesis_Homo sapiens_hsa052040.67760585
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67495104
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64857048
104Pyruvate metabolism_Homo sapiens_hsa006200.64705949
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61506292
106p53 signaling pathway_Homo sapiens_hsa041150.60838318
107Linoleic acid metabolism_Homo sapiens_hsa005910.60030410
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59265058
109Acute myeloid leukemia_Homo sapiens_hsa052210.58977595
110VEGF signaling pathway_Homo sapiens_hsa043700.58899017
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58300162
112Endocytosis_Homo sapiens_hsa041440.58247996
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58107901
114Vitamin digestion and absorption_Homo sapiens_hsa049770.56039620
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55452179
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54124656
117Pancreatic cancer_Homo sapiens_hsa052120.52355219
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51298556
119DNA replication_Homo sapiens_hsa030300.51156378
120Regulation of autophagy_Homo sapiens_hsa041400.46753383
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46225353
122Adherens junction_Homo sapiens_hsa045200.45035012
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44648335
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44391259
125Pentose phosphate pathway_Homo sapiens_hsa000300.42673716
126Notch signaling pathway_Homo sapiens_hsa043300.42327575
127Pertussis_Homo sapiens_hsa051330.39241787
128Olfactory transduction_Homo sapiens_hsa047400.38674568
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.38348652
130Steroid biosynthesis_Homo sapiens_hsa001000.37295559
131Ether lipid metabolism_Homo sapiens_hsa005650.36175080
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36012606
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.35865839
134Prolactin signaling pathway_Homo sapiens_hsa049170.34477451
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33665392
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33620864
137Other glycan degradation_Homo sapiens_hsa005110.32961760
138Arachidonic acid metabolism_Homo sapiens_hsa005900.32757138
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32693692
140African trypanosomiasis_Homo sapiens_hsa051430.32332155
141Retinol metabolism_Homo sapiens_hsa008300.31587675
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31258690
143Rap1 signaling pathway_Homo sapiens_hsa040150.30972851
144N-Glycan biosynthesis_Homo sapiens_hsa005100.30640208
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.29944676
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29359915
147Oocyte meiosis_Homo sapiens_hsa041140.28506523
148ABC transporters_Homo sapiens_hsa020100.28280850
149Asthma_Homo sapiens_hsa053100.28210324
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28057785
151MAPK signaling pathway_Homo sapiens_hsa040100.26789454
152Spliceosome_Homo sapiens_hsa030400.26523222
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.26141515
154Fatty acid degradation_Homo sapiens_hsa000710.26113867
155Colorectal cancer_Homo sapiens_hsa052100.25795460
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25667691
157Proteasome_Homo sapiens_hsa030500.25554906
158Small cell lung cancer_Homo sapiens_hsa052220.23146133
159Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21742953
160Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21495759
161Alcoholism_Homo sapiens_hsa050340.20866195
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20175220
163Rheumatoid arthritis_Homo sapiens_hsa053230.18266890
164mTOR signaling pathway_Homo sapiens_hsa041500.17883689
165Basal transcription factors_Homo sapiens_hsa030220.16771496
166Base excision repair_Homo sapiens_hsa034100.15640119
167Cell cycle_Homo sapiens_hsa041100.15365696
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13928892
169Neurotrophin signaling pathway_Homo sapiens_hsa047220.12370387
170FoxO signaling pathway_Homo sapiens_hsa040680.11830395
171Mineral absorption_Homo sapiens_hsa049780.09321535
172RNA degradation_Homo sapiens_hsa030180.08475316
173Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07941846

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