ITGA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)8.17799168
2positive regulation of vasculogenesis (GO:2001214)4.85306818
3cardiac myofibril assembly (GO:0055003)4.58243642
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.45217640
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.19447313
6cellular response to epinephrine stimulus (GO:0071872)4.19444079
7glucocorticoid biosynthetic process (GO:0006704)4.19366768
8surfactant homeostasis (GO:0043129)4.05103535
9actin-myosin filament sliding (GO:0033275)3.89959958
10muscle filament sliding (GO:0030049)3.89959958
11definitive hemopoiesis (GO:0060216)3.89473707
12response to epinephrine (GO:0071871)3.84760723
13regulation of vasculogenesis (GO:2001212)3.83352807
14myofibril assembly (GO:0030239)3.80524991
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.71922500
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.67740442
17notochord development (GO:0030903)3.67112549
18daunorubicin metabolic process (GO:0044597)3.59218327
19polyketide metabolic process (GO:0030638)3.59218327
20doxorubicin metabolic process (GO:0044598)3.59218327
21androgen biosynthetic process (GO:0006702)3.51075827
22negative regulation of potassium ion transmembrane transport (GO:1901380)3.49309264
23sarcomere organization (GO:0045214)3.47964728
24angiogenesis involved in wound healing (GO:0060055)3.47395987
25bone trabecula formation (GO:0060346)3.45856634
26negative regulation of erythrocyte differentiation (GO:0045647)3.44190854
27cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.43877745
28striated muscle hypertrophy (GO:0014897)3.37952937
29regulation of cardioblast differentiation (GO:0051890)3.32076455
30cell proliferation involved in metanephros development (GO:0072203)3.31902031
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30953890
32regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28225187
33actin-mediated cell contraction (GO:0070252)3.26812629
34cardiac muscle cell development (GO:0055013)3.26576208
35glucocorticoid metabolic process (GO:0008211)3.22263302
36muscle hypertrophy (GO:0014896)3.22251955
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.21052785
38cardiac muscle contraction (GO:0060048)3.15705453
39cardiac cell development (GO:0055006)3.14704816
40chemical homeostasis within a tissue (GO:0048875)3.14433471
41cell proliferation involved in kidney development (GO:0072111)3.12646921
42cellular response to gonadotropin stimulus (GO:0071371)3.11458845
43regulation of endothelial cell differentiation (GO:0045601)3.09807884
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.09553512
45vascular endothelial growth factor signaling pathway (GO:0038084)3.07671479
46positive regulation of odontogenesis (GO:0042482)3.06198226
47positive regulation of DNA-dependent DNA replication (GO:2000105)3.06002076
48positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.04688459
49paraxial mesoderm development (GO:0048339)3.03008245
50cellular response to growth hormone stimulus (GO:0071378)3.01850555
51hormone catabolic process (GO:0042447)3.01201402
52lateral sprouting from an epithelium (GO:0060601)3.00837844
53complement activation, alternative pathway (GO:0006957)2.99712598
54cellular response to antibiotic (GO:0071236)2.97517787
55trabecula formation (GO:0060343)2.88451501
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86227028
57regulation of actin filament-based movement (GO:1903115)2.85249825
58regulation of skeletal muscle contraction (GO:0014819)2.81670247
59basement membrane organization (GO:0071711)2.79397402
60positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.77023228
61negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75931849
62branching involved in salivary gland morphogenesis (GO:0060445)2.74658227
63labyrinthine layer development (GO:0060711)2.74096788
64sarcoplasmic reticulum calcium ion transport (GO:0070296)2.74046757
65fibroblast migration (GO:0010761)2.72551367
66cardiac muscle cell proliferation (GO:0060038)2.72104140
67craniofacial suture morphogenesis (GO:0097094)2.71686307
68cardiac muscle hypertrophy in response to stress (GO:0014898)2.71415403
69muscle hypertrophy in response to stress (GO:0003299)2.71415403
70cardiac muscle adaptation (GO:0014887)2.71415403
71actin filament-based movement (GO:0030048)2.71379676
72fatty acid transmembrane transport (GO:1902001)2.71294617
73negative regulation of blood vessel endothelial cell migration (GO:0043537)2.71087148
74positive regulation of SMAD protein import into nucleus (GO:0060391)2.70457935
75regulation of transforming growth factor beta2 production (GO:0032909)2.70324186
76heart morphogenesis (GO:0003007)2.70101736
77positive regulation of endothelial cell differentiation (GO:0045603)2.69719255
78carnitine shuttle (GO:0006853)2.69666081
79mesenchymal cell proliferation (GO:0010463)2.68520039
80heart trabecula formation (GO:0060347)2.67323894
81regulation of non-canonical Wnt signaling pathway (GO:2000050)2.66721328
82ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.65404512
83adult heart development (GO:0007512)2.64869330
84thyroid gland development (GO:0030878)2.63690440
85blood vessel maturation (GO:0001955)2.63419905
86bundle of His cell to Purkinje myocyte communication (GO:0086069)2.61509393
87C21-steroid hormone biosynthetic process (GO:0006700)2.61348763
88regulation of relaxation of muscle (GO:1901077)2.60758710
89striated muscle contraction (GO:0006941)2.60699148
90regulation of SMAD protein import into nucleus (GO:0060390)2.60663673
91regulation of smooth muscle cell differentiation (GO:0051150)2.60068383
92cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.59080873
93regulation of female gonad development (GO:2000194)2.57657380
94regulation of hippo signaling (GO:0035330)2.56772284
95regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55740349
96endothelial tube morphogenesis (GO:0061154)2.55468281
97morphogenesis of an endothelium (GO:0003159)2.55468281
98heart contraction (GO:0060047)2.54642397
99heart process (GO:0003015)2.54642397
100cell communication by electrical coupling (GO:0010644)2.54285831
101NLS-bearing protein import into nucleus (GO:0006607)2.53974662
102prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53631634
103negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.53217743
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.51628989
105cardiac muscle tissue morphogenesis (GO:0055008)2.51233747
106regulation of complement activation (GO:0030449)2.50442568
107regulation of striated muscle contraction (GO:0006942)2.50233278
108apoptotic cell clearance (GO:0043277)2.49962457
109interkinetic nuclear migration (GO:0022027)2.48962171
110actomyosin structure organization (GO:0031032)2.47519984
111lymphangiogenesis (GO:0001946)2.46318762
112plasma membrane repair (GO:0001778)2.46147547
113negative regulation of granulocyte differentiation (GO:0030853)2.46082021
114cGMP-mediated signaling (GO:0019934)2.45131087
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43649199
116epithelial cell differentiation involved in kidney development (GO:0035850)2.43492033
117pinocytosis (GO:0006907)2.42751904
118glomerular filtration (GO:0003094)2.42688541
119endocardial cushion development (GO:0003197)2.42657404
120primitive streak formation (GO:0090009)2.42243641
121regulation of tight junction assembly (GO:2000810)2.42041869
122thrombin receptor signaling pathway (GO:0070493)2.41765912
123cell communication involved in cardiac conduction (GO:0086065)2.41575812
124cranial suture morphogenesis (GO:0060363)2.41412545
125regulation of protein activation cascade (GO:2000257)2.40104324
126mesenchymal-epithelial cell signaling (GO:0060638)2.39207048
127positive regulation of fatty acid beta-oxidation (GO:0032000)2.38966119
128glomerular basement membrane development (GO:0032836)2.36527422
129cell differentiation involved in metanephros development (GO:0072202)2.35935175
130response to follicle-stimulating hormone (GO:0032354)2.35669572
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35433458
132positive regulation of focal adhesion assembly (GO:0051894)2.35421760
133positive regulation of cell junction assembly (GO:1901890)2.35421760
134lymph vessel development (GO:0001945)2.34706899
135epoxygenase P450 pathway (GO:0019373)2.34464523
136positive regulation of adherens junction organization (GO:1903393)2.34220716
137cell migration involved in sprouting angiogenesis (GO:0002042)2.33883281
138cell migration involved in heart development (GO:0060973)2.32822182
139somite rostral/caudal axis specification (GO:0032525)2.32504559
140relaxation of cardiac muscle (GO:0055119)2.32298913
141vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32161539
142Notch signaling involved in heart development (GO:0061314)2.31442245
143cellular response to toxic substance (GO:0097237)2.31229090
144smooth muscle tissue development (GO:0048745)2.31125011
145sprouting angiogenesis (GO:0002040)2.30509292
146keratan sulfate catabolic process (GO:0042340)2.30095906
147cellular response to thyroid hormone stimulus (GO:0097067)2.29812163
148striated muscle adaptation (GO:0014888)2.29676454
149coronary vasculature morphogenesis (GO:0060977)2.29085583
150phagocytosis, recognition (GO:0006910)2.28580661
151negative regulation of norepinephrine secretion (GO:0010700)2.28344827
152positive regulation of protein kinase C signaling (GO:0090037)2.27817258
153organ induction (GO:0001759)2.27794428
154pathway-restricted SMAD protein phosphorylation (GO:0060389)2.27608963
155epithelial cell-cell adhesion (GO:0090136)2.27415169
156muscle tissue morphogenesis (GO:0060415)2.27272350
157regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.26825246
158negative regulation of vascular permeability (GO:0043116)2.25993645
159cardiac muscle hypertrophy (GO:0003300)2.25338332
160Rap protein signal transduction (GO:0032486)2.25193845
161cellular response to dexamethasone stimulus (GO:0071549)2.24565342
162negative regulation of endothelial cell migration (GO:0010596)2.24492682
163cytoplasmic mRNA processing body assembly (GO:0033962)2.23537896
164retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22772151
165hippo signaling (GO:0035329)2.22575820
166anatomical structure regression (GO:0060033)2.22575756
167type B pancreatic cell development (GO:0003323)2.22130857
168renal filtration (GO:0097205)2.22042322
169regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21507707
170outflow tract septum morphogenesis (GO:0003148)2.21324000
171patterning of blood vessels (GO:0001569)2.21031825
172branching involved in labyrinthine layer morphogenesis (GO:0060670)2.20430875
173venous blood vessel morphogenesis (GO:0048845)2.20298647
174regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.19987619
175ventricular cardiac muscle cell action potential (GO:0086005)2.19633373
176positive regulation of fatty acid oxidation (GO:0046321)2.19606706
177regulation of vascular permeability (GO:0043114)2.18604170
178mesodermal cell differentiation (GO:0048333)2.18456198
179regulation of alkaline phosphatase activity (GO:0010692)2.17691748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.25377814
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.25377814
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.25377814
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.18512481
5GATA1_22025678_ChIP-Seq_K562_Human3.09284421
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.70968410
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67817704
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.53539642
9SCL_19346495_ChIP-Seq_HPC-7_Human2.50524101
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.45160150
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43930467
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.39809648
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.36030378
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29934171
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.21933410
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15267511
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08229204
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04352276
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.99876296
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.98739302
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.98739302
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98535776
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.97516818
24* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92622088
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.91854853
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88621142
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84048959
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79014495
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.75900638
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.73682385
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72267464
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.71166419
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.67043425
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.63267962
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.63199422
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62706064
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62470253
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56177260
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.55814884
40* BP1_19119308_ChIP-ChIP_Hs578T_Human1.55630091
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54987508
42GATA1_19941826_ChIP-Seq_K562_Human1.54561437
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54162844
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53865316
45* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53817755
46CLOCK_20551151_ChIP-Seq_293T_Human1.52939515
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52193453
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52193453
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51951280
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51803716
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50899921
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50851429
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49132063
54* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44295131
55EZH2_22144423_ChIP-Seq_EOC_Human1.44271220
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43482638
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42906298
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41916005
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41572222
60GBX2_23144817_ChIP-Seq_PC3_Human1.41569777
61* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.41295021
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39690352
63* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39416186
64VDR_24787735_ChIP-Seq_THP-1_Human1.38392923
65* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37695359
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36469523
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35865192
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35053024
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34985087
70* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34289522
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33617811
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.32514992
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32215870
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.31275627
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30735425
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.29953078
77CJUN_26792858_Chip-Seq_BT549_Human1.26775989
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26617183
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.26375781
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25607351
81BRD4_25478319_ChIP-Seq_HGPS_Human1.25186307
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24919312
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22840068
84IGF1R_20145208_ChIP-Seq_DFB_Human1.21439114
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20817728
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.20246909
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.20107107
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19537871
89* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19337542
90DROSHA_22980978_ChIP-Seq_HELA_Human1.18193573
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18153420
92PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17733216
93AHR_22903824_ChIP-Seq_MCF-7_Human1.17132321
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17011610
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16749565
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16391890
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15346216
98GATA2_19941826_ChIP-Seq_K562_Human1.13313140
99SPI1_23127762_ChIP-Seq_K562_Human1.12657745
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12290837
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12290837
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12264098
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11267093
104KDM2B_26808549_Chip-Seq_K562_Human1.11222162
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10551918
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10147518
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09927551
108* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09587738
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.09553047
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09018080
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07880071
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07264433
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06840603
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06210668
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06033919
116* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05748622
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04313162
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02625122
119TCF7_22412390_ChIP-Seq_EML_Mouse1.02571491
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02102406
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01830158
122AR_21909140_ChIP-Seq_LNCAP_Human1.00998591
123* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00258988
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.00095729
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99966453
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98123691
127RUNX_20019798_ChIP-Seq_JUKART_Human0.98081996
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97934480
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96180155
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95728210
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94738923
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94239221
133* SMAD4_21799915_ChIP-Seq_A2780_Human0.93771853
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91871759
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91380693
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.91319146
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91180756
138IRF8_27001747_Chip-Seq_BMDM_Mouse0.90959518
139POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90464532
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90158957
141VDR_24763502_ChIP-Seq_THP-1_Human0.89738479
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.89070501
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88264062
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88007033
145EED_16625203_ChIP-ChIP_MESCs_Mouse0.87552475
146* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87341328
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86510177
148* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85989718
149* SMAD3_21741376_ChIP-Seq_EPCs_Human0.84988745
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84706853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.31318250
2MP0004084_abnormal_cardiac_muscle3.22284378
3MP0004272_abnormal_basement_membrane2.86853121
4MP0008438_abnormal_cutaneous_collagen2.84416104
5MP0000465_gastrointestinal_hemorrhage2.71567411
6MP0002837_dystrophic_cardiac_calcinosis2.66305411
7MP0003646_muscle_fatigue2.55345033
8* MP0010368_abnormal_lymphatic_system2.48523918
9MP0005503_abnormal_tendon_morphology2.36644446
10MP0005257_abnormal_intraocular_pressure2.26919990
11MP0005167_abnormal_blood-brain_barrier2.26624808
12MP0000751_myopathy2.14459683
13MP0005165_increased_susceptibility_to2.05127082
14MP0004510_myositis2.00576425
15MP0004782_abnormal_surfactant_physiolog1.98954254
16MP0006054_spinal_hemorrhage1.96551106
17MP0004036_abnormal_muscle_relaxation1.95340280
18MP0004215_abnormal_myocardial_fiber1.91255543
19MP0008775_abnormal_heart_ventricle1.90804379
20MP0003303_peritoneal_inflammation1.89956827
21MP0001958_emphysema1.82412287
22MP0005275_abnormal_skin_tensile1.81801743
23MP0000767_abnormal_smooth_muscle1.79258139
24MP0004145_abnormal_muscle_electrophysio1.79061402
25MP0000013_abnormal_adipose_tissue1.77295555
26MP0005330_cardiomyopathy1.77167730
27MP0010630_abnormal_cardiac_muscle1.76194523
28MP0006138_congestive_heart_failure1.71322963
29MP0003279_aneurysm1.70797830
30MP0004087_abnormal_muscle_fiber1.62081347
31MP0002972_abnormal_cardiac_muscle1.60030509
32MP0003724_increased_susceptibility_to1.59610287
33MP0003566_abnormal_cell_adhesion1.58523869
34MP0005670_abnormal_white_adipose1.57966922
35MP0002127_abnormal_cardiovascular_syste1.55612572
36MP0010030_abnormal_orbit_morphology1.54989446
37MP0005248_abnormal_Harderian_gland1.54079122
38MP0005595_abnormal_vascular_smooth1.51509042
39MP0002138_abnormal_hepatobiliary_system1.50071878
40MP0000750_abnormal_muscle_regeneration1.49321093
41MP0005187_abnormal_penis_morphology1.48986463
42MP0005409_darkened_coat_color1.48278399
43MP0003252_abnormal_bile_duct1.47285929
44MP0002139_abnormal_hepatobiliary_system1.46942596
45MP0003828_pulmonary_edema1.46940038
46MP0005464_abnormal_platelet_physiology1.46284999
47MP0001879_abnormal_lymphatic_vessel1.43989947
48MP0009278_abnormal_bone_marrow1.41747463
49MP0001544_abnormal_cardiovascular_syste1.41389785
50MP0005385_cardiovascular_system_phenoty1.41389785
51MP0001661_extended_life_span1.38549196
52MP0002295_abnormal_pulmonary_circulatio1.36959562
53MP0000749_muscle_degeneration1.33919113
54MP0000566_synostosis1.31767059
55MP0005508_abnormal_skeleton_morphology1.31001181
56MP0003935_abnormal_craniofacial_develop1.30057475
57MP0002332_abnormal_exercise_endurance1.29857166
58MP0002925_abnormal_cardiovascular_devel1.29034429
59MP0002108_abnormal_muscle_morphology1.28406169
60MP0004264_abnormal_extraembryonic_tissu1.27431387
61MP0005620_abnormal_muscle_contractility1.26394549
62MP0005397_hematopoietic_system_phenotyp1.25592140
63MP0001545_abnormal_hematopoietic_system1.25592140
64MP0003137_abnormal_impulse_conducting1.23630760
65MP0002249_abnormal_larynx_morphology1.23205327
66MP0003385_abnormal_body_wall1.22661423
67MP0009250_abnormal_appendicular_skeleto1.21845191
68MP0002088_abnormal_embryonic_growth/wei1.21600549
69MP0000266_abnormal_heart_morphology1.21432847
70MP0002932_abnormal_joint_morphology1.20492696
71MP0000343_altered_response_to1.20191073
72MP0000534_abnormal_ureter_morphology1.19938156
73MP0003011_delayed_dark_adaptation1.17365569
74MP0004808_abnormal_hematopoietic_stem1.17268579
75MP0003984_embryonic_growth_retardation1.17244765
76MP0003300_gastrointestinal_ulcer1.17125835
77MP0003045_fibrosis1.16759538
78* MP0002128_abnormal_blood_circulation1.16123950
79MP0000681_abnormal_thyroid_gland1.15816237
80MP0005085_abnormal_gallbladder_physiolo1.15716299
81MP0009697_abnormal_copulation1.12736356
82MP0002269_muscular_atrophy1.11861214
83MP0003942_abnormal_urinary_system1.11840803
84MP0001851_eye_inflammation1.11752166
85MP0004130_abnormal_muscle_cell1.09534119
86MP0004085_abnormal_heartbeat1.09364632
87MP0005058_abnormal_lysosome_morphology1.08987707
88MP0002998_abnormal_bone_remodeling1.08361440
89MP0001614_abnormal_blood_vessel1.07652494
90MP0008995_early_reproductive_senescence1.06436658
91MP0000428_abnormal_craniofacial_morphol1.06400875
92MP0005380_embryogenesis_phenotype1.06225082
93MP0001672_abnormal_embryogenesis/_devel1.06225082
94MP0000249_abnormal_blood_vessel1.03225090
95MP0000230_abnormal_systemic_arterial1.02976736
96MP0004484_altered_response_of1.02970207
97MP0003283_abnormal_digestive_organ1.02456403
98MP0002282_abnormal_trachea_morphology1.01652928
99MP0004185_abnormal_adipocyte_glucose1.00676239
100MP0005666_abnormal_adipose_tissue1.00427257
101MP0002254_reproductive_system_inflammat0.98461986
102MP0003191_abnormal_cellular_cholesterol0.96764611
103MP0001915_intracranial_hemorrhage0.95793664
104MP0005369_muscle_phenotype0.95683411
105MP0002106_abnormal_muscle_physiology0.95283518
106MP0003115_abnormal_respiratory_system0.94698032
107MP0005360_urolithiasis0.93876631
108MP0005451_abnormal_body_composition0.93654354
109MP0003937_abnormal_limbs/digits/tail_de0.93409564
110MP0001849_ear_inflammation0.93169840
111MP0000733_abnormal_muscle_development0.93126910
112* MP0001175_abnormal_lung_morphology0.91796281
113MP0003122_maternal_imprinting0.91256822
114MP0000639_abnormal_adrenal_gland0.89594092
115MP0009384_cardiac_valve_regurgitation0.89399829
116MP0008004_abnormal_stomach_pH0.89065155
117MP0002086_abnormal_extraembryonic_tissu0.87458584
118MP0005623_abnormal_meninges_morphology0.86744006
119MP0005365_abnormal_bile_salt0.86202524
120MP0002938_white_spotting0.86062443
121MP0004883_abnormal_blood_vessel0.85799010
122* MP0005023_abnormal_wound_healing0.84600721
123MP0001293_anophthalmia0.84432350
124MP0003567_abnormal_fetal_cardiomyocyte0.84195048
125MP0003091_abnormal_cell_migration0.83467268
126MP0002168_other_aberrant_phenotype0.83263762
127MP0000432_abnormal_head_morphology0.82634160
128MP0000759_abnormal_skeletal_muscle0.82335859
129MP0003950_abnormal_plasma_membrane0.82230981
130MP0005375_adipose_tissue_phenotype0.82041946
131MP0000747_muscle_weakness0.80988083
132MP0002085_abnormal_embryonic_tissue0.80259989
133MP0002933_joint_inflammation0.79937407
134MP0000762_abnormal_tongue_morphology0.79724486
135MP0003890_abnormal_embryonic-extraembry0.79012763
136MP0009840_abnormal_foam_cell0.77390481
137MP0002396_abnormal_hematopoietic_system0.74198714
138MP0000462_abnormal_digestive_system0.72203531
139MP0000383_abnormal_hair_follicle0.71986701
140MP0002133_abnormal_respiratory_system0.70176634
141MP0005388_respiratory_system_phenotype0.70176634
142MP0005647_abnormal_sex_gland0.68663402
143MP0005166_decreased_susceptibility_to0.66100644
144MP0001501_abnormal_sleep_pattern0.65280844
145MP0003075_altered_response_to0.64189260
146MP0001784_abnormal_fluid_regulation0.64154398
147MP0003943_abnormal_hepatobiliary_system0.63339071
148MP0000003_abnormal_adipose_tissue0.62833438
149MP0002896_abnormal_bone_mineralization0.62569042
150MP0010678_abnormal_skin_adnexa0.61370730
151MP0002009_preneoplasia0.58204596

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)4.28621154
2Distal arthrogryposis (HP:0005684)3.82496408
3Ventricular tachycardia (HP:0004756)3.81673241
4Sudden death (HP:0001699)3.64563862
5Bundle branch block (HP:0011710)3.64010983
6Systemic lupus erythematosus (HP:0002725)3.54598142
7Abnormality of complement system (HP:0005339)3.51543863
8Short 4th metacarpal (HP:0010044)3.48596355
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.48596355
10Spontaneous hematomas (HP:0007420)3.47903222
11Midline defect of the nose (HP:0004122)3.43510603
12Bilateral microphthalmos (HP:0007633)3.30986046
13Protrusio acetabuli (HP:0003179)3.27045600
14Thyroid-stimulating hormone excess (HP:0002925)3.23514707
15Atrial fibrillation (HP:0005110)3.16800388
16Cerebral aneurysm (HP:0004944)3.15613944
17Shallow orbits (HP:0000586)3.14135637
18Abnormality of the 4th metacarpal (HP:0010012)3.08726876
19Increased connective tissue (HP:0009025)3.07727828
20Hepatoblastoma (HP:0002884)3.02261166
21Deep venous thrombosis (HP:0002625)3.00245162
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.93131053
23Exercise-induced myalgia (HP:0003738)2.92625372
24Aortic aneurysm (HP:0004942)2.91236822
25Primary atrial arrhythmia (HP:0001692)2.89390257
26Round ear (HP:0100830)2.85810658
27Hypoplasia of the iris (HP:0007676)2.82466826
28Abnormality of the distal phalanx of the thumb (HP:0009617)2.82005401
29Aortic dissection (HP:0002647)2.78377900
30Supraventricular arrhythmia (HP:0005115)2.76379513
31Gonadal dysgenesis (HP:0000133)2.74325578
32Lymphangioma (HP:0100764)2.74133652
33Increased variability in muscle fiber diameter (HP:0003557)2.73191222
34Supraventricular tachycardia (HP:0004755)2.71542463
35Glomerulonephritis (HP:0000099)2.70428990
36Right ventricular cardiomyopathy (HP:0011663)2.68736548
37Hypochromic microcytic anemia (HP:0004840)2.62658066
38Aneurysm (HP:0002617)2.62304272
39Abnormality of skeletal muscle fiber size (HP:0012084)2.60621596
40Shawl scrotum (HP:0000049)2.58311625
41Lipoatrophy (HP:0100578)2.57993104
42Decreased circulating renin level (HP:0003351)2.56487034
43Abnormality of the parietal bone (HP:0002696)2.51127672
44Mitral valve prolapse (HP:0001634)2.49318606
45Ankle contracture (HP:0006466)2.48973656
46Ventricular fibrillation (HP:0001663)2.46153269
47EMG: myopathic abnormalities (HP:0003458)2.40327789
48Nasolacrimal duct obstruction (HP:0000579)2.37472786
49Partial duplication of thumb phalanx (HP:0009944)2.36937460
50Ulnar deviation of the wrist (HP:0003049)2.35232669
51Muscle fiber splitting (HP:0003555)2.35134101
52Partial duplication of the phalanx of hand (HP:0009999)2.31568250
53Hypoplastic ischia (HP:0003175)2.31098453
54Complement deficiency (HP:0004431)2.28133753
55Type 1 muscle fiber predominance (HP:0003803)2.27782035
56Camptodactyly of toe (HP:0001836)2.22903112
57Intestinal fistula (HP:0100819)2.21660880
58EMG: neuropathic changes (HP:0003445)2.20866107
59Arterial tortuosity (HP:0005116)2.20846286
60Prolonged bleeding time (HP:0003010)2.20334493
61Esophageal varix (HP:0002040)2.20256223
62Neoplasm of the heart (HP:0100544)2.18374616
63Pulmonary artery stenosis (HP:0004415)2.17435284
64Rectovaginal fistula (HP:0000143)2.16152116
65Rectal fistula (HP:0100590)2.16152116
66Exercise-induced muscle cramps (HP:0003710)2.14067416
67Portal hypertension (HP:0001409)2.13959437
68Skin pits (HP:0100276)2.13944960
69Abnormality of the left ventricular outflow tract (HP:0011103)2.11108214
70Subaortic stenosis (HP:0001682)2.11108214
71Multiple enchondromatosis (HP:0005701)2.10024315
72Limited hip movement (HP:0008800)2.09069333
73Myotonia (HP:0002486)2.08832539
74Neck muscle weakness (HP:0000467)2.08014188
75Nephritis (HP:0000123)2.07533254
76Depressed nasal tip (HP:0000437)2.07324562
77Hyporeflexia of lower limbs (HP:0002600)2.07071882
78Abnormality of the ischium (HP:0003174)2.06925567
79Asymmetric septal hypertrophy (HP:0001670)2.06831649
80Hyperpituitarism (HP:0010514)2.06546414
81Visceral angiomatosis (HP:0100761)2.05970198
82Preaxial foot polydactyly (HP:0001841)2.05323435
83Distal lower limb muscle weakness (HP:0009053)2.05292764
84Atrioventricular block (HP:0001678)2.05028459
85Abnormality of the fingertips (HP:0001211)2.03927715
86Wide anterior fontanel (HP:0000260)2.03050264
87Vascular tortuosity (HP:0004948)2.02813582
88Abnormal cartilage morphology (HP:0002763)2.02452781
89Hemangiomatosis (HP:0007461)2.02324106
90Prolonged QT interval (HP:0001657)2.00999321
91Peritonitis (HP:0002586)2.00556440
92Broad toe (HP:0001837)2.00387971
93Ulnar bowing (HP:0003031)1.99455395
94Vaginal fistula (HP:0004320)1.99432388
95Trigonocephaly (HP:0000243)1.99215665
96Skull defect (HP:0001362)1.98886042
97Mildly elevated creatine phosphokinase (HP:0008180)1.95931240
98Supernumerary ribs (HP:0005815)1.95841636
99Abnormality of the lacrimal duct (HP:0011481)1.95559721
100Bulbar palsy (HP:0001283)1.95544985
101Neoplasm of striated muscle (HP:0009728)1.95532766
102Abnormality of the pubic bones (HP:0003172)1.94451094
103Premature rupture of membranes (HP:0001788)1.94076587
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93735904
105Renal duplication (HP:0000075)1.93731749
106Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.92902222
107Abnormality of the salivary glands (HP:0010286)1.92453483
108Facial diplegia (HP:0001349)1.92004502
109Syncope (HP:0001279)1.91647407
110Difficulty running (HP:0009046)1.91494953
111Preauricular pit (HP:0004467)1.91220490
112Periauricular skin pits (HP:0100277)1.91220490
113Overgrowth (HP:0001548)1.90591708
114Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89085936
115Abnormality of the calf musculature (HP:0001430)1.88090117
116Interstitial pulmonary disease (HP:0006530)1.87848116
117Male infertility (HP:0003251)1.87743952
118Stroke (HP:0001297)1.87127895
119Testicular neoplasm (HP:0010788)1.86749438
120Hematochezia (HP:0002573)1.86553721
121Abnormality of the hepatic vasculature (HP:0006707)1.86331100
122Testicular atrophy (HP:0000029)1.85861149
123Tetraparesis (HP:0002273)1.85592668
124Hemorrhage of the eye (HP:0011885)1.85112487
125Wrist flexion contracture (HP:0001239)1.85027154
126Calf muscle hypertrophy (HP:0008981)1.84987763
127Disproportionate tall stature (HP:0001519)1.84532842
128Epistaxis (HP:0000421)1.84422054
129Nemaline bodies (HP:0003798)1.83828251
130Cutaneous syndactyly (HP:0012725)1.83662899
131Dilated cardiomyopathy (HP:0001644)1.83528966
132Muscle hypertrophy of the lower extremities (HP:0008968)1.83495466
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83106564
134Rib fusion (HP:0000902)1.82741401
135Flat capital femoral epiphysis (HP:0003370)1.82562298
136Skin nodule (HP:0200036)1.82517417
137Accelerated skeletal maturation (HP:0005616)1.82161848
138Toxemia of pregnancy (HP:0100603)1.81748699
139Recurrent gram-negative bacterial infections (HP:0005420)1.77948435
140Ventricular arrhythmia (HP:0004308)1.77798814
141Abnormality of the nasolacrimal system (HP:0000614)1.77402507
142Muscle fiber inclusion bodies (HP:0100299)1.76932740
143Polycythemia (HP:0001901)1.75470377
144Purpura (HP:0000979)1.75162499
145Heart block (HP:0012722)1.74504151
146Areflexia of lower limbs (HP:0002522)1.72784907
147Conjunctival telangiectasia (HP:0000524)1.72680088
148Striae distensae (HP:0001065)1.72643575
149Exostoses (HP:0100777)1.72415226
150Sudden cardiac death (HP:0001645)1.72410379
151Hip contracture (HP:0003273)1.72335918
152Mesomelia (HP:0003027)1.71669565
153Abnormal atrioventricular conduction (HP:0005150)1.71581353
154Relative macrocephaly (HP:0004482)1.70836233
155Germ cell neoplasia (HP:0100728)1.70622860
156Abnormal EKG (HP:0003115)1.70408990
157Bradycardia (HP:0001662)1.70198086
158Fused cervical vertebrae (HP:0002949)1.70122970
159Malignant hyperthermia (HP:0002047)1.68432692
160Absent phalangeal crease (HP:0006109)1.67868431
161Abnormality of the periventricular white matter (HP:0002518)1.67056545
162Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.66926731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.14263278
2CDK124.04039192
3TGFBR23.87673322
4TIE12.98716333
5ERN12.83570068
6TTN2.55028023
7TRIB32.38274110
8KIT2.26734222
9DMPK2.25635394
10LATS22.24865070
11AKT32.11646058
12STK38L2.06118904
13PKN22.05643871
14RIPK12.04906218
15FES2.02343040
16PDGFRA1.91341666
17DAPK21.84078672
18PIK3CG1.81108424
19TRPM71.80188625
20PRPF4B1.78228915
21TTK1.70688319
22FGFR21.68682870
23MOS1.62043600
24STK101.57528827
25LMTK21.50149916
26MYLK1.44763521
27GRK51.44565071
28CAMK1D1.42413374
29SIK11.41556139
30MAP2K31.39957149
31STK31.36127478
32PINK11.36019233
33TYRO31.32679911
34CDC42BPA1.31511417
35ERBB41.31452808
36STK241.30709888
37GRK71.26775234
38CSF1R1.26471143
39ZAP701.26204963
40PAK41.19831997
41MAPK71.15743419
42KDR1.15668945
43MAP3K61.09482842
44EPHA31.06353659
45MAP3K51.04005195
46MAP3K101.03041277
47FGFR31.02707727
48PIK3CA1.02479051
49TEC1.02269328
50DDR20.99943705
51CAMK40.99149477
52MUSK0.98723568
53OBSCN0.96190824
54ACVR1B0.95894523
55NEK90.95599357
56TAOK30.95408408
57CDK80.93689559
58PRKAA20.93451461
59GRK10.93106764
60PDGFRB0.92123182
61CAMK1G0.89440361
62WNK10.88708211
63TGFBR10.88651663
64EEF2K0.88538258
65CDK60.87452629
66MAP3K70.87317507
67MTOR0.81047859
68KSR20.80426381
69NLK0.77963231
70MELK0.77302829
71FGFR40.76872779
72MARK20.75854689
73TAOK10.73885114
74MAP3K10.72947011
75PRKD10.72757912
76PHKG20.72067989
77PHKG10.72067989
78EPHB20.71249583
79GRK60.71176263
80MAPK120.70841709
81BTK0.68214147
82HCK0.66840440
83SYK0.65770094
84PRKAA10.64614837
85TBK10.64350616
86MAPKAPK30.63648871
87SGK20.63544820
88PTK60.63325609
89CDK90.62780979
90MAP3K140.62158616
91JAK10.61571789
92DAPK30.61559191
93PTK20.61248575
94MAP2K40.60879184
95STK40.60744730
96MET0.59842819
97BMPR1B0.59223525
98MAPK40.57992474
99RPS6KL10.57028960
100RPS6KC10.57028960
101MAP3K130.56722300
102EPHB10.56631388
103MATK0.56094493
104BRD40.54230975
105BLK0.53466440
106CDK70.52937349
107IRAK10.52161580
108STK380.52082891
109RPS6KA20.51507945
110FER0.50493323
111IGF1R0.49016210
112NUAK10.48583761
113SGK30.47967513
114FLT30.47954636
115AKT20.47656993
116PRKG20.47291893
117BMX0.46413871
118ILK0.45947932
119RET0.45704085
120MKNK10.45580448
121RPS6KA60.45437547
122GSK3A0.45289546
123ERBB20.45257967
124MAP4K10.45210574
125CDK40.44982610
126MAPK30.44464134
127JAK20.44383203
128TNK20.43282694
129BCKDK0.41904318
130CHEK20.41754745
131ROCK10.41416147
132CHUK0.41071966
133PRKD20.40914722
134PDPK10.40659304
135MST1R0.40644572
136LRRK20.40071597
137EGFR0.39500803
138PAK20.39269233
139INSRR0.39002405
140CSK0.38630044
141PDK10.38157772
142PDK30.38066036
143PDK40.38066036
144PRKG10.37981093
145ADRBK20.37822532
146JAK30.37147382
147ROCK20.36647395
148FGFR10.36609772
149LCK0.34614881
150PRKACG0.33667766
151ITK0.33636119

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.29115309
2Complement and coagulation cascades_Homo sapiens_hsa046102.25174662
3Ovarian steroidogenesis_Homo sapiens_hsa049132.23524387
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15337741
5* Dilated cardiomyopathy_Homo sapiens_hsa054142.07866998
6* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04645408
7Adherens junction_Homo sapiens_hsa045201.99357000
8Renin secretion_Homo sapiens_hsa049241.87382074
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79140290
10* ECM-receptor interaction_Homo sapiens_hsa045121.77669967
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77576775
12Lysine degradation_Homo sapiens_hsa003101.71435016
13Tryptophan metabolism_Homo sapiens_hsa003801.65888120
14Fatty acid metabolism_Homo sapiens_hsa012121.62685192
15Staphylococcus aureus infection_Homo sapiens_hsa051501.62278782
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58894804
17TGF-beta signaling pathway_Homo sapiens_hsa043501.57601007
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.56760241
19Basal cell carcinoma_Homo sapiens_hsa052171.56274984
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56117759
21PPAR signaling pathway_Homo sapiens_hsa033201.56115553
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56097044
23* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54701196
24Arginine biosynthesis_Homo sapiens_hsa002201.50890570
25* Focal adhesion_Homo sapiens_hsa045101.50529100
26Propanoate metabolism_Homo sapiens_hsa006401.47951597
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46325109
28Vitamin B6 metabolism_Homo sapiens_hsa007501.36928650
29Small cell lung cancer_Homo sapiens_hsa052221.34783312
30Nitrogen metabolism_Homo sapiens_hsa009101.29673231
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22989824
32Hedgehog signaling pathway_Homo sapiens_hsa043401.22019367
33Viral myocarditis_Homo sapiens_hsa054161.20387934
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20128912
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19318051
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19253944
37Asthma_Homo sapiens_hsa053101.18776461
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17495529
39MicroRNAs in cancer_Homo sapiens_hsa052061.13019979
40Insulin resistance_Homo sapiens_hsa049311.12605450
41Notch signaling pathway_Homo sapiens_hsa043301.12277242
42Hippo signaling pathway_Homo sapiens_hsa043901.10911361
43Proteoglycans in cancer_Homo sapiens_hsa052051.09540721
44Renin-angiotensin system_Homo sapiens_hsa046141.08613547
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08586996
46Prion diseases_Homo sapiens_hsa050201.07576663
47Pancreatic cancer_Homo sapiens_hsa052121.05602699
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04609052
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01974273
50Amoebiasis_Homo sapiens_hsa051461.00153044
51Pertussis_Homo sapiens_hsa051330.99768672
52Protein digestion and absorption_Homo sapiens_hsa049740.98939360
53Oxytocin signaling pathway_Homo sapiens_hsa049210.94079627
54Pathways in cancer_Homo sapiens_hsa052000.93720081
55Thyroid hormone synthesis_Homo sapiens_hsa049180.93323964
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.93186042
57Calcium signaling pathway_Homo sapiens_hsa040200.93094446
58Gastric acid secretion_Homo sapiens_hsa049710.92210957
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91431568
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.88824209
61Leishmaniasis_Homo sapiens_hsa051400.87513426
62Pancreatic secretion_Homo sapiens_hsa049720.85782525
63Gap junction_Homo sapiens_hsa045400.82872705
64Salivary secretion_Homo sapiens_hsa049700.82461466
65Rap1 signaling pathway_Homo sapiens_hsa040150.81330304
66Starch and sucrose metabolism_Homo sapiens_hsa005000.81091841
67Carbon metabolism_Homo sapiens_hsa012000.81076551
68Bile secretion_Homo sapiens_hsa049760.79953257
69GnRH signaling pathway_Homo sapiens_hsa049120.79923983
70mTOR signaling pathway_Homo sapiens_hsa041500.79134257
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79046534
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.79025516
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78863494
74Autoimmune thyroid disease_Homo sapiens_hsa053200.78684410
75* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78046163
76AMPK signaling pathway_Homo sapiens_hsa041520.76186819
77Butanoate metabolism_Homo sapiens_hsa006500.76023706
78Dorso-ventral axis formation_Homo sapiens_hsa043200.75978649
79Thyroid cancer_Homo sapiens_hsa052160.75866454
80Chemical carcinogenesis_Homo sapiens_hsa052040.75173972
81beta-Alanine metabolism_Homo sapiens_hsa004100.74951799
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74064318
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.72296641
84Histidine metabolism_Homo sapiens_hsa003400.72208605
85Retinol metabolism_Homo sapiens_hsa008300.72063613
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71906322
87Chronic myeloid leukemia_Homo sapiens_hsa052200.68838974
88Melanoma_Homo sapiens_hsa052180.68763057
89Circadian rhythm_Homo sapiens_hsa047100.68093652
90Colorectal cancer_Homo sapiens_hsa052100.67438907
91* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66947409
92Toxoplasmosis_Homo sapiens_hsa051450.66792620
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66304711
94Linoleic acid metabolism_Homo sapiens_hsa005910.66277850
95Arachidonic acid metabolism_Homo sapiens_hsa005900.66165448
96Caffeine metabolism_Homo sapiens_hsa002320.66094323
97Prostate cancer_Homo sapiens_hsa052150.65744618
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65705586
99Tight junction_Homo sapiens_hsa045300.65273716
100Acute myeloid leukemia_Homo sapiens_hsa052210.65190544
101Galactose metabolism_Homo sapiens_hsa000520.65070685
102Osteoclast differentiation_Homo sapiens_hsa043800.64895171
103Circadian entrainment_Homo sapiens_hsa047130.64127620
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63664101
105Renal cell carcinoma_Homo sapiens_hsa052110.62260123
106ABC transporters_Homo sapiens_hsa020100.60708430
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.60465091
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60351122
109VEGF signaling pathway_Homo sapiens_hsa043700.60195669
110Endometrial cancer_Homo sapiens_hsa052130.58483073
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56768121
112Other glycan degradation_Homo sapiens_hsa005110.56286290
113Wnt signaling pathway_Homo sapiens_hsa043100.56100761
114Bladder cancer_Homo sapiens_hsa052190.55809341
115Long-term depression_Homo sapiens_hsa047300.55695532
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55658534
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55586296
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55435666
119Fatty acid biosynthesis_Homo sapiens_hsa000610.55217328
120Peroxisome_Homo sapiens_hsa041460.55186909
121Platelet activation_Homo sapiens_hsa046110.54964592
122cAMP signaling pathway_Homo sapiens_hsa040240.54847106
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.54727147
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53935716
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52483179
126Tyrosine metabolism_Homo sapiens_hsa003500.51598571
127Malaria_Homo sapiens_hsa051440.51514334
128Systemic lupus erythematosus_Homo sapiens_hsa053220.50589827
129Pyruvate metabolism_Homo sapiens_hsa006200.50371210
130Lysosome_Homo sapiens_hsa041420.50151353
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49351705
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49337921
133Hematopoietic cell lineage_Homo sapiens_hsa046400.48772776
134Prolactin signaling pathway_Homo sapiens_hsa049170.48733289
135Estrogen signaling pathway_Homo sapiens_hsa049150.48556135
136Cell cycle_Homo sapiens_hsa041100.47871366
137Insulin signaling pathway_Homo sapiens_hsa049100.47393965
138Choline metabolism in cancer_Homo sapiens_hsa052310.46553612
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46404959
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.45453705
141Ras signaling pathway_Homo sapiens_hsa040140.43794238
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.41414826
143* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41179112

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