ITGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.78044196
2cell adhesion mediated by integrin (GO:0033627)6.35370244
3glomerular visceral epithelial cell development (GO:0072015)5.78751836
4glomerular epithelial cell development (GO:0072310)5.32471156
5cytoskeletal anchoring at plasma membrane (GO:0007016)4.94674505
6regulation of hippo signaling (GO:0035330)4.87653439
7cell-substrate junction assembly (GO:0007044)4.79135016
8glomerular basement membrane development (GO:0032836)4.71549497
9epithelial cell-cell adhesion (GO:0090136)4.69963768
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.61810163
11* mesodermal cell differentiation (GO:0048333)4.40646112
12desmosome organization (GO:0002934)4.29611971
13activation of Rac GTPase activity (GO:0032863)4.16491779
14hippo signaling (GO:0035329)4.11407723
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.00034777
16negative regulation of chondrocyte differentiation (GO:0032331)3.98512975
17hypotonic response (GO:0006971)3.96563764
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.86099832
19respiratory tube development (GO:0030323)3.85783556
20cell migration involved in sprouting angiogenesis (GO:0002042)3.85537265
21hepatocyte apoptotic process (GO:0097284)3.78774027
22adherens junction assembly (GO:0034333)3.77340036
23polarized epithelial cell differentiation (GO:0030859)3.75942286
24establishment of apical/basal cell polarity (GO:0035089)3.74582342
25skin morphogenesis (GO:0043589)3.72236708
26branching involved in salivary gland morphogenesis (GO:0060445)3.68000831
27lymphangiogenesis (GO:0001946)3.63364654
28wound healing, spreading of epidermal cells (GO:0035313)3.60347059
29tight junction assembly (GO:0070830)3.60260806
30keratinocyte proliferation (GO:0043616)3.59882966
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53101728
32protein retention in ER lumen (GO:0006621)3.51893220
33lung vasculature development (GO:0060426)3.49723154
34interferon-gamma secretion (GO:0072643)3.48861899
35cellular response to vitamin (GO:0071295)3.47762858
36regulation of glomerular filtration (GO:0003093)3.47254154
37lung epithelium development (GO:0060428)3.45457525
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42926544
39embryonic foregut morphogenesis (GO:0048617)3.42563040
40regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.42421771
41negative regulation of keratinocyte proliferation (GO:0010839)3.40304317
42protein localization to endosome (GO:0036010)3.37575034
43focal adhesion assembly (GO:0048041)3.37087927
44cell-substrate adherens junction assembly (GO:0007045)3.37087927
45lung-associated mesenchyme development (GO:0060484)3.36531264
46actin filament depolymerization (GO:0030042)3.36215897
47endothelial cell chemotaxis (GO:0035767)3.33326887
48membrane raft organization (GO:0031579)3.31706514
49membrane protein ectodomain proteolysis (GO:0006509)3.27456572
50collecting duct development (GO:0072044)3.25569943
51muscle cell migration (GO:0014812)3.25285147
52substrate-dependent cell migration (GO:0006929)3.24564771
53stress fiber assembly (GO:0043149)3.21879493
54cell junction assembly (GO:0034329)3.21747035
55cell-cell junction assembly (GO:0007043)3.21081318
56establishment of monopolar cell polarity (GO:0061162)3.19608305
57establishment or maintenance of monopolar cell polarity (GO:0061339)3.19608305
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19530276
59plasma membrane repair (GO:0001778)3.19200145
60surfactant homeostasis (GO:0043129)3.18195998
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.18077544
62blood vessel endothelial cell migration (GO:0043534)3.17352471
63vascular endothelial growth factor signaling pathway (GO:0038084)3.16996768
64* positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.14769883
65positive regulation of blood vessel endothelial cell migration (GO:0043536)3.12378491
66renal system development (GO:0072001)3.09900543
67lung lobe morphogenesis (GO:0060463)3.06121656
68positive regulation of endothelial cell apoptotic process (GO:2000353)3.05900617
69negative regulation of cell fate specification (GO:0009996)3.04936331
70cell junction organization (GO:0034330)3.04271434
71adherens junction organization (GO:0034332)3.04156661
72mammary gland epithelial cell proliferation (GO:0033598)3.02491485
73apoptotic process involved in morphogenesis (GO:0060561)3.02231601
74endodermal cell differentiation (GO:0035987)3.01693848
75regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97458805
76renal system process involved in regulation of blood volume (GO:0001977)2.96947701
77wound healing, spreading of cells (GO:0044319)2.96820125
78negative regulation of anoikis (GO:2000811)2.95125920
79establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.94683026
80regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.94425803
81paraxial mesoderm development (GO:0048339)2.94243136
82* positive regulation of protein localization to plasma membrane (GO:1903078)2.93070413
83regulation of water loss via skin (GO:0033561)2.91830147
84positive regulation of osteoblast proliferation (GO:0033690)2.90742596
85endothelial cell morphogenesis (GO:0001886)2.90322705
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89670983
87ectoderm development (GO:0007398)2.88756355
88membrane budding (GO:0006900)2.87630935
89gap junction assembly (GO:0016264)2.87105186
90basement membrane organization (GO:0071711)2.85245997
91positive regulation of p38MAPK cascade (GO:1900745)2.83842041
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82012790
93barbed-end actin filament capping (GO:0051016)2.81602432
94regulation of tight junction assembly (GO:2000810)2.80816763
95atrioventricular valve morphogenesis (GO:0003181)2.80496009
96intestinal epithelial cell development (GO:0060576)2.80150382
97protein hydroxylation (GO:0018126)2.78438157
98regulation of cell fate specification (GO:0042659)2.78344961
99substrate adhesion-dependent cell spreading (GO:0034446)2.77559622
100facial nerve structural organization (GO:0021612)2.77506685
101endocytic recycling (GO:0032456)2.76575708
102chondrocyte proliferation (GO:0035988)2.75542033
103establishment or maintenance of apical/basal cell polarity (GO:0035088)2.75462286
104establishment or maintenance of bipolar cell polarity (GO:0061245)2.75462286
105negative regulation of cartilage development (GO:0061037)2.74695246
106actin filament bundle organization (GO:0061572)2.74053822
107actin filament bundle assembly (GO:0051017)2.74053822
108heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.72642800
109regulation of transforming growth factor beta2 production (GO:0032909)2.71306656
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69825414
111embryonic camera-type eye development (GO:0031076)2.69567854
112mitotic nuclear envelope reassembly (GO:0007084)2.69341521
113nuclear envelope reassembly (GO:0031468)2.69341521
114semaphorin-plexin signaling pathway (GO:0071526)2.68381452
115negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.68301043
116cellular copper ion homeostasis (GO:0006878)2.67541776
117extracellular matrix disassembly (GO:0022617)2.67007438
118branching involved in mammary gland duct morphogenesis (GO:0060444)2.66278750
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66183749
120establishment of endothelial barrier (GO:0061028)2.65851468
121establishment of skin barrier (GO:0061436)2.64811500
122positive regulation of actin filament depolymerization (GO:0030836)2.64043909
123cell-cell junction organization (GO:0045216)2.63885907
124apoptotic cell clearance (GO:0043277)2.62969098
125axon extension involved in axon guidance (GO:0048846)2.62316380
126neuron projection extension involved in neuron projection guidance (GO:1902284)2.62316380
127regulation of anoikis (GO:2000209)2.61270134
128regulation of early endosome to late endosome transport (GO:2000641)2.60255711
129glomerulus development (GO:0032835)2.58486197
130cellular response to vitamin D (GO:0071305)2.56807924
131lens fiber cell development (GO:0070307)2.56387976
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54464887
133regulation of gene silencing by RNA (GO:0060966)2.53817741
134regulation of posttranscriptional gene silencing (GO:0060147)2.53817741
135regulation of gene silencing by miRNA (GO:0060964)2.53817741
136establishment of epithelial cell polarity (GO:0090162)2.52947022
137Golgi transport vesicle coating (GO:0048200)2.52915741
138COPI coating of Golgi vesicle (GO:0048205)2.52915741
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52297417
140negative regulation of fatty acid transport (GO:2000192)2.52168335
141regulation of cardioblast differentiation (GO:0051890)2.51320906
142regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.51067822
143protein localization to microtubule (GO:0035372)2.50987474
144positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49681494
145peptidyl-proline hydroxylation (GO:0019511)2.48253599
146collagen metabolic process (GO:0032963)2.47863605
147glial cell migration (GO:0008347)2.44367336
148positive regulation of positive chemotaxis (GO:0050927)2.43501462
149regulation of endothelial cell chemotaxis (GO:2001026)2.43345313
150regulation of establishment of planar polarity (GO:0090175)2.41996608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human7.33649663
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.82246826
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.72512327
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.70335706
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.60333865
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14395621
7CLOCK_20551151_ChIP-Seq_293T_Human2.93358637
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.90231246
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.88939400
10ZNF263_19887448_ChIP-Seq_K562_Human2.46653533
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.35395579
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.33870411
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.33870411
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.32325635
15* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.26627271
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20923735
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15330198
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.15210638
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00192918
20ATF3_27146783_Chip-Seq_COLON_Human2.00105140
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.95716567
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90906853
23RACK7_27058665_Chip-Seq_MCF-7_Human1.89646668
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.87562724
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87258426
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.87222605
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.86255488
28* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79533964
29* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79133150
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.79060622
31* GATA6_25053715_ChIP-Seq_YYC3_Human1.70628588
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70392843
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70363992
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.69155306
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69023950
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68990400
37* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67475239
38* SOX2_20726797_ChIP-Seq_SW620_Human1.65558035
39AR_21909140_ChIP-Seq_LNCAP_Human1.65006511
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.63721537
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63310714
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.59722299
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.57703464
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56906412
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55889514
46* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54267049
47GATA4_25053715_ChIP-Seq_YYC3_Human1.53908336
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.53475525
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.51457218
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49678848
51* KLF5_25053715_ChIP-Seq_YYC3_Human1.47187293
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46060458
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45767985
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44268454
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40197516
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39214266
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39123056
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36994110
59* CJUN_26792858_Chip-Seq_BT549_Human1.36863493
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36086367
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35653259
62* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33701575
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.32604692
64* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32586089
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30171003
66* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27583395
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27118505
68* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27048511
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26095218
70KDM2B_26808549_Chip-Seq_K562_Human1.25879120
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23075020
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21760216
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18842475
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17434098
75* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17012807
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16779835
77TP53_23651856_ChIP-Seq_MEFs_Mouse1.16582531
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16329223
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16055418
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15827246
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.15249695
82* BRD4_25478319_ChIP-Seq_HGPS_Human1.15058618
83GATA3_24758297_ChIP-Seq_MCF-7_Human1.15044026
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.14190425
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13698255
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11564388
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11356737
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09953209
89TP53_22127205_ChIP-Seq_IMR90_Human1.09259219
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08671887
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08144781
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08006088
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.07639289
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07006060
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06390185
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.05860688
97* LXR_22292898_ChIP-Seq_THP-1_Human1.05395527
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05365591
99KDM2B_26808549_Chip-Seq_DND41_Human1.05357381
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05164333
101CHD1_26751641_Chip-Seq_LNCaP_Human1.04351574
102* TP63_22573176_ChIP-Seq_HFKS_Human1.00181344
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99580966
104* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98746669
105* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98288453
106* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98288453
107CREB1_26743006_Chip-Seq_LNCaP_Human0.98261007
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97546222
109* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97366012
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96946488
111TCF7_22412390_ChIP-Seq_EML_Mouse0.96283891
112TP53_16413492_ChIP-PET_HCT116_Human0.92281289
113* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92233947
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91126352
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91123998
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91050682
117* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90802544
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.90393759
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89778383
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89292792
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88458434
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87387442
123EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86457894
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84341837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.87181248
2MP0004272_abnormal_basement_membrane3.67695823
3MP0003705_abnormal_hypodermis_morpholog3.63015286
4MP0003566_abnormal_cell_adhesion3.21438835
5MP0010352_gastrointestinal_tract_polyps3.16555366
6MP0005623_abnormal_meninges_morphology3.12643962
7MP0003950_abnormal_plasma_membrane2.69348931
8MP0002796_impaired_skin_barrier2.45626904
9* MP0000537_abnormal_urethra_morphology2.39624061
10MP0004264_abnormal_extraembryonic_tissu2.37327286
11MP0005257_abnormal_intraocular_pressure2.35483269
12MP0001849_ear_inflammation2.29771123
13MP0009053_abnormal_anal_canal2.22431522
14MP0003300_gastrointestinal_ulcer2.20934433
15MP0010678_abnormal_skin_adnexa2.17075219
16MP0010368_abnormal_lymphatic_system2.10046242
17MP0002877_abnormal_melanocyte_morpholog2.08122471
18MP0003453_abnormal_keratinocyte_physiol1.98123127
19MP0010030_abnormal_orbit_morphology1.93107325
20MP0005275_abnormal_skin_tensile1.91978029
21MP0005409_darkened_coat_color1.88930837
22MP0003091_abnormal_cell_migration1.88564296
23MP0003191_abnormal_cellular_cholesterol1.86423192
24MP0005501_abnormal_skin_physiology1.85488795
25MP0003941_abnormal_skin_development1.77468981
26MP0005076_abnormal_cell_differentiation1.71023758
27MP0005167_abnormal_blood-brain_barrier1.67630218
28MP0002234_abnormal_pharynx_morphology1.65653570
29MP0000751_myopathy1.61263797
30* MP0005023_abnormal_wound_healing1.59578153
31MP0001348_abnormal_lacrimal_gland1.56900425
32MP0002254_reproductive_system_inflammat1.56410159
33MP0002060_abnormal_skin_morphology1.53454113
34MP0000383_abnormal_hair_follicle1.53289728
35MP0000462_abnormal_digestive_system1.52287629
36MP0003283_abnormal_digestive_organ1.45757308
37MP0000467_abnormal_esophagus_morphology1.45453613
38MP0004084_abnormal_cardiac_muscle1.44729743
39MP0009840_abnormal_foam_cell1.44173202
40MP0000762_abnormal_tongue_morphology1.42381122
41MP0009384_cardiac_valve_regurgitation1.40373465
42MP0000733_abnormal_muscle_development1.37450744
43MP0001958_emphysema1.35521271
44MP0001879_abnormal_lymphatic_vessel1.35490444
45MP0002098_abnormal_vibrissa_morphology1.34957240
46* MP0001216_abnormal_epidermal_layer1.30947149
47MP0003942_abnormal_urinary_system1.29917031
48MP0005367_renal/urinary_system_phenotyp1.29609146
49MP0000516_abnormal_urinary_system1.29609146
50MP0000579_abnormal_nail_morphology1.27792649
51MP0006054_spinal_hemorrhage1.27773200
52MP0005360_urolithiasis1.24094837
53* MP0003115_abnormal_respiratory_system1.23614312
54MP0005451_abnormal_body_composition1.22864502
55MP0003119_abnormal_digestive_system1.22766587
56MP0002138_abnormal_hepatobiliary_system1.20287484
57* MP0000534_abnormal_ureter_morphology1.20058721
58MP0002896_abnormal_bone_mineralization1.13768831
59MP0000627_abnormal_mammary_gland1.12411187
60MP0005197_abnormal_uvea_morphology1.11477488
61MP0000858_altered_metastatic_potential1.10899600
62MP0010771_integument_phenotype1.10669705
63MP0001346_abnormal_lacrimal_gland1.09611589
64MP0008260_abnormal_autophagy1.08900716
65MP0002925_abnormal_cardiovascular_devel1.06940158
66MP0000566_synostosis1.06326020
67MP0002086_abnormal_extraembryonic_tissu1.04570564
68MP0009780_abnormal_chondrocyte_physiolo1.03800066
69MP0003045_fibrosis1.02705213
70MP0002697_abnormal_eye_size1.01243101
71MP0002089_abnormal_postnatal_growth/wei0.98646583
72MP0000749_muscle_degeneration0.98557487
73MP0001243_abnormal_dermal_layer0.98517153
74MP0005058_abnormal_lysosome_morphology0.98453044
75MP0003329_amyloid_beta_deposits0.98141248
76MP0004185_abnormal_adipocyte_glucose0.96878102
77* MP0000477_abnormal_intestine_morphology0.95901038
78MP0005621_abnormal_cell_physiology0.93925259
79MP0001730_embryonic_growth_arrest0.93258925
80MP0000377_abnormal_hair_follicle0.92701912
81MP0006138_congestive_heart_failure0.92521897
82MP0003755_abnormal_palate_morphology0.92258158
83MP0005165_increased_susceptibility_to0.91342998
84MP0005164_abnormal_response_to0.89620334
85MP0005508_abnormal_skeleton_morphology0.89157906
86* MP0002084_abnormal_developmental_patter0.88098006
87MP0004233_abnormal_muscle_weight0.87887264
88MP0001614_abnormal_blood_vessel0.86939459
89MP0001915_intracranial_hemorrhage0.85783139
90MP0001666_abnormal_nutrient_absorption0.84606859
91MP0003984_embryonic_growth_retardation0.83320919
92MP0000428_abnormal_craniofacial_morphol0.82943233
93MP0000538_abnormal_urinary_bladder0.82376387
94MP0003385_abnormal_body_wall0.82089813
95MP0002088_abnormal_embryonic_growth/wei0.81965146
96MP0000013_abnormal_adipose_tissue0.79662829
97* MP0002085_abnormal_embryonic_tissue0.79607163
98MP0005187_abnormal_penis_morphology0.79600739
99MP0003935_abnormal_craniofacial_develop0.79386159
100MP0002295_abnormal_pulmonary_circulatio0.79104946
101MP0003279_aneurysm0.78221139
102MP0002233_abnormal_nose_morphology0.78152008
103* MP0004197_abnormal_fetal_growth/weight/0.77851965
104MP0001299_abnormal_eye_distance/0.77728224
105MP0004858_abnormal_nervous_system0.77644674
106MP0001672_abnormal_embryogenesis/_devel0.77319514
107MP0005380_embryogenesis_phenotype0.77319514
108* MP0009931_abnormal_skin_appearance0.77278770
109MP0001881_abnormal_mammary_gland0.77104355
110MP0000750_abnormal_muscle_regeneration0.76390854
111MP0005595_abnormal_vascular_smooth0.76016598
112MP0003252_abnormal_bile_duct0.75985183
113MP0000767_abnormal_smooth_muscle0.75806866
114MP0004782_abnormal_surfactant_physiolog0.75526403
115MP0005375_adipose_tissue_phenotype0.75418431
116MP0002177_abnormal_outer_ear0.75259016
117MP0010630_abnormal_cardiac_muscle0.74291174
118MP0000003_abnormal_adipose_tissue0.74250440
119MP0003315_abnormal_perineum_morphology0.74220932
120* MP0002136_abnormal_kidney_physiology0.73919949
121MP0000678_abnormal_parathyroid_gland0.73788585
122MP0002111_abnormal_tail_morphology0.73696858
123MP0002092_abnormal_eye_morphology0.73595279
124MP0008438_abnormal_cutaneous_collagen0.73317470
125* MP0002135_abnormal_kidney_morphology0.73200576
126* MP0005193_abnormal_anterior_eye0.72976370
127MP0001286_abnormal_eye_development0.72878415
128MP0004133_heterotaxia0.72218498
129* MP0003937_abnormal_limbs/digits/tail_de0.72012234
130MP0001661_extended_life_span0.71124215
131MP0005330_cardiomyopathy0.70687775
132MP0000759_abnormal_skeletal_muscle0.70614351
133MP0000432_abnormal_head_morphology0.69745380
134MP0001340_abnormal_eyelid_morphology0.69567710
135MP0005083_abnormal_biliary_tract0.68524587
136MP0001542_abnormal_bone_strength0.68355572
137MP0004087_abnormal_muscle_fiber0.65730794
138MP0003448_altered_tumor_morphology0.64352696

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)5.16118402
2Onycholysis (HP:0001806)5.01342034
3Atrophic scars (HP:0001075)4.90062197
4Right ventricular cardiomyopathy (HP:0011663)4.50209329
5Fragile nails (HP:0001808)4.18657720
6* Focal segmental glomerulosclerosis (HP:0000097)4.03991876
7Thick nail (HP:0001805)3.53347071
8* Glomerulosclerosis (HP:0000096)3.36151934
9Natal tooth (HP:0000695)3.20345335
10Mesangial abnormality (HP:0001966)3.18103061
11Shallow orbits (HP:0000586)3.13400283
12Micronodular cirrhosis (HP:0001413)3.07259859
13Plantar hyperkeratosis (HP:0007556)3.04756761
14Pili torti (HP:0003777)3.04653018
15Cerebral aneurysm (HP:0004944)3.04365065
16Vertebral compression fractures (HP:0002953)2.98622618
17Flat acetabular roof (HP:0003180)2.92967221
18Rectal prolapse (HP:0002035)2.87628451
19Abnormality of nail color (HP:0100643)2.87471553
20Bronchomalacia (HP:0002780)2.84882941
21Fragile skin (HP:0001030)2.80992307
22Hyperacusis (HP:0010780)2.79815084
23Esophageal varix (HP:0002040)2.78689192
24Hypoalbuminemia (HP:0003073)2.72529495
25Abnormal albumin level (HP:0012116)2.72529495
26Radial bowing (HP:0002986)2.69841161
27Cervical subluxation (HP:0003308)2.67630545
28* Nail dystrophy (HP:0008404)2.63987225
29Spinal rigidity (HP:0003306)2.60822872
30Short nail (HP:0001799)2.59123102
31Wormian bones (HP:0002645)2.52565857
32Aortic aneurysm (HP:0004942)2.47371660
33Lymphangioma (HP:0100764)2.46895554
34Esophageal atresia (HP:0002032)2.46033028
35Pterygium (HP:0001059)2.44977774
36Distal upper limb amyotrophy (HP:0007149)2.43610377
37Upper limb amyotrophy (HP:0009129)2.43610377
38Bowed forearm bones (HP:0003956)2.43244983
39Bowing of the arm (HP:0006488)2.43244983
40Ankle contracture (HP:0006466)2.40204106
41Hypoplasia of dental enamel (HP:0006297)2.38497193
42Increased connective tissue (HP:0009025)2.37035991
43Abnormality of the gastric mucosa (HP:0004295)2.36107150
44Protrusio acetabuli (HP:0003179)2.33782805
45Broad face (HP:0000283)2.32669160
46Lower limb amyotrophy (HP:0007210)2.31378351
47Palmoplantar hyperkeratosis (HP:0000972)2.29108927
48Subacute progressive viral hepatitis (HP:0006572)2.27676513
49Alopecia of scalp (HP:0002293)2.27154475
50Aneurysm (HP:0002617)2.25618120
51Bladder diverticulum (HP:0000015)2.22105341
52Cardiovascular calcification (HP:0011915)2.20103371
53Entropion (HP:0000621)2.19103223
54Neurofibrillary tangles (HP:0002185)2.18487693
55Curly hair (HP:0002212)2.18424172
56Achilles tendon contracture (HP:0001771)2.16571711
57Ulnar bowing (HP:0003031)2.15524018
58Reduced subcutaneous adipose tissue (HP:0003758)2.15448571
59Woolly hair (HP:0002224)2.14694594
60Facial shape deformation (HP:0011334)2.13230181
61Potter facies (HP:0002009)2.13230181
62Arterial tortuosity (HP:0005116)2.13172900
63Mildly elevated creatine phosphokinase (HP:0008180)2.12140162
64Selective tooth agenesis (HP:0001592)2.12028220
65Difficulty climbing stairs (HP:0003551)2.11716215
66Mitral regurgitation (HP:0001653)2.11710273
67Palmar hyperkeratosis (HP:0010765)2.10877824
68Cerebral inclusion bodies (HP:0100314)2.10809748
69Hand muscle atrophy (HP:0009130)2.10313226
70Hematochezia (HP:0002573)2.10295329
71Distal lower limb muscle weakness (HP:0009053)2.07178316
72Premature rupture of membranes (HP:0001788)2.05080126
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.04675147
74Osteolytic defects of the hand bones (HP:0009699)2.04675147
75Biliary tract neoplasm (HP:0100574)2.04536645
76Spondylolisthesis (HP:0003302)2.04068331
77Elbow flexion contracture (HP:0002987)2.03163759
78Abnormality of the distal phalanges of the toes (HP:0010182)2.00792770
79Tibial bowing (HP:0002982)2.00459211
80Fused cervical vertebrae (HP:0002949)2.00051724
81Abnormality of oral frenula (HP:0000190)1.99656713
82Stage 5 chronic kidney disease (HP:0003774)1.99254199
83Vascular calcification (HP:0004934)1.97800979
84Vascular tortuosity (HP:0004948)1.96984536
85Hyporeflexia of lower limbs (HP:0002600)1.96947870
86Ankyloglossia (HP:0010296)1.96321337
87Abnormality of the calcaneus (HP:0008364)1.96143942
88Ureteral stenosis (HP:0000071)1.91413762
89Abdominal distention (HP:0003270)1.90801130
90Aortic regurgitation (HP:0001659)1.89957633
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.89861639
92Nephritis (HP:0000123)1.89611032
93Abnormal ossification of hand bones (HP:0005921)1.88383647
94Mitral stenosis (HP:0001718)1.87167761
95Deviation of the thumb (HP:0009603)1.87050183
96Increased density of long bones (HP:0006392)1.86582478
97Insomnia (HP:0100785)1.86239673
98Glucose intolerance (HP:0000833)1.86142129
99Scapular winging (HP:0003691)1.85542049
100Back pain (HP:0003418)1.85218141
101Abnormality of the Achilles tendon (HP:0005109)1.84968241
102Germ cell neoplasia (HP:0100728)1.84616220
103Thin bony cortex (HP:0002753)1.84511918
104Aplasia cutis congenita (HP:0001057)1.83555097
105Abnormal vertebral ossification (HP:0100569)1.83504653
106Short humerus (HP:0005792)1.83454725
107Down-sloping shoulders (HP:0200021)1.82818910
108Increased mean platelet volume (HP:0011877)1.80173247
109Absent frontal sinuses (HP:0002688)1.78742924
110Blue sclerae (HP:0000592)1.78408760
111Nuclear cataract (HP:0100018)1.78378755
112Spinal cord compression (HP:0002176)1.78246651
113Coronal craniosynostosis (HP:0004440)1.76291861
114Abnormality of carpal bone ossification (HP:0006257)1.75985819
115Aortic dissection (HP:0002647)1.75359346
116Spinal cord lesions (HP:0100561)1.75256197
117Syringomyelia (HP:0003396)1.75256197
118Fibular aplasia (HP:0002990)1.74922744
119Coxa vara (HP:0002812)1.74407964
120Ureteral obstruction (HP:0006000)1.74310232
121Urethral obstruction (HP:0000796)1.72016388
122Wrist flexion contracture (HP:0001239)1.71579182
123Tubular atrophy (HP:0000092)1.71340330
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71118087
125Vertebral hypoplasia (HP:0008417)1.71118087
126Abnormality of the acetabulum (HP:0003170)1.70371628
127Muscle fiber splitting (HP:0003555)1.70350773
128Long toe (HP:0010511)1.70165535
129Aplasia/Hypoplasia of the clavicles (HP:0006710)1.70106522
130Vertebral arch anomaly (HP:0008438)1.69662583
131Trismus (HP:0000211)1.69049359
132Abnormality of dentin (HP:0010299)1.67079294
133Follicular hyperkeratosis (HP:0007502)1.66332414
134Axonal loss (HP:0003447)1.65757730
135Acanthosis nigricans (HP:0000956)1.64623951
136Distal lower limb amyotrophy (HP:0008944)1.64146816
137Mitral valve prolapse (HP:0001634)1.64107265
138Neonatal death (HP:0003811)1.63334811
139Abnormal hair laboratory examination (HP:0003328)1.63180615
140Abnormality of the nasal septum (HP:0000419)1.62978344
141* Abnormal blistering of the skin (HP:0008066)1.62693483
142Shawl scrotum (HP:0000049)1.62237090
143Malignant gastrointestinal tract tumors (HP:0006749)1.61727997
144Gastrointestinal carcinoma (HP:0002672)1.61727997
145Advanced eruption of teeth (HP:0006288)1.61565627
146Abnormal hemoglobin (HP:0011902)1.61527933
147Ridged nail (HP:0001807)1.61073768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.37081964
2MST43.18397092
3TTN2.75360237
4EPHB22.56887870
5IRAK32.52871699
6TRIB32.41962455
7LATS12.39561324
8PTK22.38121567
9FER2.36461608
10PAK42.31057843
11RIPK12.27633733
12PTK62.18192556
13RPS6KB21.97490140
14PKN21.92837493
15LRRK21.89217192
16PDGFRA1.80559618
17STK101.77895211
18NME21.65464585
19MAP2K21.60538142
20MET1.58827613
21MST1R1.55207026
22SMG11.47379710
23CDK121.45786992
24ARAF1.41023334
25TESK11.39042800
26DDR21.38597836
27MOS1.37977821
28MAP3K21.36402039
29FRK1.34565048
30EPHB11.33223047
31EEF2K1.33042510
32LATS21.28971970
33MAP3K31.25918580
34TGFBR11.23471782
35ERN11.23058083
36BMX1.19798812
37PAK21.19120033
38TIE11.19051200
39TGFBR21.16225683
40PAK31.07633841
41MAP2K11.06867316
42PRKG21.04537460
43WNK41.04143460
44PIM21.02224146
45PRKCI1.00737448
46MAP3K80.94627857
47CDK80.94293084
48FGFR40.93642583
49MTOR0.93346468
50FGFR10.92177847
51NTRK10.90060100
52MAP3K60.89597492
53MAPKAPK30.88871733
54SCYL20.87518809
55PRKD20.82716438
56RPS6KA20.82344381
57STK38L0.80245297
58LMTK20.80021755
59LIMK10.79576719
60PDGFRB0.76359663
61TRPM70.74717435
62SIK10.74308537
63STK30.73304234
64KDR0.71519280
65DMPK0.69260918
66NEK10.67887726
67CDK60.66463690
68STK390.66384678
69ALK0.64741395
70MAP3K70.63536673
71MYLK0.62244535
72ROCK10.60956501
73ROCK20.58876579
74MAP3K90.58844080
75TESK20.57134829
76ILK0.53761298
77MAP3K130.51073199
78ABL20.50927028
79RPS6KA40.50644629
80DYRK1B0.50063974
81MAP3K120.48481587
82AKT20.48266006
83NEK90.48054329
84BRAF0.47176461
85BUB10.46554057
86RET0.46262295
87ERBB40.46216338
88GSK3A0.46109939
89EGFR0.46054891
90PASK0.45148813
91ERBB20.44893721
92TYRO30.44334441
93STK380.43493504
94PRPF4B0.42193111
95AKT30.42069258
96CAMK2G0.41905269
97CAMK2B0.40572231
98SRC0.40249017
99MAP3K100.40225747
100KSR10.39640435
101MAP2K30.38940454
102NEK20.38353087
103MELK0.37117435
104KSR20.37035778
105CDK90.36836257
106BCR0.36281384
107ZAP700.36149188
108PAK60.35416147
109SIK30.34534860
110PAK10.33536132
111INSR0.33014460
112PRKD10.32544482
113TAOK20.32466803
114CDC42BPA0.32433031
115ICK0.31692778
116PRKD30.31556502
117FGFR20.31350094
118CHUK0.30873117
119PTK2B0.30745605
120AURKB0.30519662
121FLT30.29590059
122PBK0.28322022
123PIK3CA0.28057964
124ERBB30.27967389
125PHKG20.27508995
126PHKG10.27508995
127PDPK10.27402651
128MAP3K10.27368165
129CAMK2D0.26540631
130MAPKAPK20.26338588
131BRSK10.25002129
132MAPK110.19219942
133AURKA0.18524642
134RPS6KC10.18182262
135RPS6KL10.18182262

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.30729370
2Adherens junction_Homo sapiens_hsa045202.99218861
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.74286265
4* Small cell lung cancer_Homo sapiens_hsa052222.69037790
5Tight junction_Homo sapiens_hsa045302.63522913
6Bladder cancer_Homo sapiens_hsa052192.61969433
7* Focal adhesion_Homo sapiens_hsa045102.58121701
8Hippo signaling pathway_Homo sapiens_hsa043902.45734081
9* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40244952
10Proteoglycans in cancer_Homo sapiens_hsa052052.36781389
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.31856384
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.13120372
13Amoebiasis_Homo sapiens_hsa051462.10891166
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.98610641
15Thyroid cancer_Homo sapiens_hsa052161.74970319
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72720318
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.69590838
18Other glycan degradation_Homo sapiens_hsa005111.62347666
19Basal cell carcinoma_Homo sapiens_hsa052171.57909009
20Protein digestion and absorption_Homo sapiens_hsa049741.45582918
21MicroRNAs in cancer_Homo sapiens_hsa052061.41476399
22Mineral absorption_Homo sapiens_hsa049781.40645048
23* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39883490
24Endometrial cancer_Homo sapiens_hsa052131.39604344
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39328818
26Hedgehog signaling pathway_Homo sapiens_hsa043401.33318823
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32317572
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28530531
29* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27884631
30Renin-angiotensin system_Homo sapiens_hsa046141.27015109
31Axon guidance_Homo sapiens_hsa043601.24335227
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22231701
33* Dilated cardiomyopathy_Homo sapiens_hsa054141.22216431
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17577634
35Rap1 signaling pathway_Homo sapiens_hsa040151.16680304
36TGF-beta signaling pathway_Homo sapiens_hsa043501.16506705
37Renal cell carcinoma_Homo sapiens_hsa052111.14041364
38* Pathways in cancer_Homo sapiens_hsa052001.13678687
39Pancreatic cancer_Homo sapiens_hsa052121.11150079
40Toxoplasmosis_Homo sapiens_hsa051451.10302524
41Fructose and mannose metabolism_Homo sapiens_hsa000511.09978186
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09561141
43Pentose phosphate pathway_Homo sapiens_hsa000301.08252312
44Prion diseases_Homo sapiens_hsa050201.07907461
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.07605747
46* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06710308
47Viral myocarditis_Homo sapiens_hsa054161.06298052
48Shigellosis_Homo sapiens_hsa051311.01937538
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00918605
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97259051
51Melanoma_Homo sapiens_hsa052180.97069045
52Prostate cancer_Homo sapiens_hsa052150.96621311
53Bile secretion_Homo sapiens_hsa049760.96011264
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95934565
55VEGF signaling pathway_Homo sapiens_hsa043700.95049423
56Thyroid hormone synthesis_Homo sapiens_hsa049180.93743762
57p53 signaling pathway_Homo sapiens_hsa041150.93435982
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87987779
59Glioma_Homo sapiens_hsa052140.87753472
60Salmonella infection_Homo sapiens_hsa051320.85141567
61Sphingolipid metabolism_Homo sapiens_hsa006000.84988725
62Melanogenesis_Homo sapiens_hsa049160.84267100
63Estrogen signaling pathway_Homo sapiens_hsa049150.82922121
64Gap junction_Homo sapiens_hsa045400.81677964
65Platelet activation_Homo sapiens_hsa046110.81122265
66Colorectal cancer_Homo sapiens_hsa052100.80557767
67Dorso-ventral axis formation_Homo sapiens_hsa043200.80499529
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80215573
69Wnt signaling pathway_Homo sapiens_hsa043100.79815901
70HIF-1 signaling pathway_Homo sapiens_hsa040660.79622024
71Notch signaling pathway_Homo sapiens_hsa043300.74579267
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73896578
73HTLV-I infection_Homo sapiens_hsa051660.71974865
74Biosynthesis of amino acids_Homo sapiens_hsa012300.71353253
75mTOR signaling pathway_Homo sapiens_hsa041500.71323787
76Apoptosis_Homo sapiens_hsa042100.71319476
77Endocytosis_Homo sapiens_hsa041440.70939194
78Vitamin B6 metabolism_Homo sapiens_hsa007500.69742517
79Lysosome_Homo sapiens_hsa041420.69575985
80Sulfur metabolism_Homo sapiens_hsa009200.66734565
81Viral carcinogenesis_Homo sapiens_hsa052030.65780958
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65708956
83Fat digestion and absorption_Homo sapiens_hsa049750.65487279
84Gastric acid secretion_Homo sapiens_hsa049710.63074806
85Non-small cell lung cancer_Homo sapiens_hsa052230.62962128
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62324764
87TNF signaling pathway_Homo sapiens_hsa046680.59557645
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.58292398
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58212218
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56214485
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.54907954
92ErbB signaling pathway_Homo sapiens_hsa040120.53411555
93Vibrio cholerae infection_Homo sapiens_hsa051100.51806712
94Acute myeloid leukemia_Homo sapiens_hsa052210.50948442
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50168411
96N-Glycan biosynthesis_Homo sapiens_hsa005100.49554191
97Hepatitis C_Homo sapiens_hsa051600.48483171
98GnRH signaling pathway_Homo sapiens_hsa049120.47446100
99Prolactin signaling pathway_Homo sapiens_hsa049170.47442042
100Glucagon signaling pathway_Homo sapiens_hsa049220.46895892
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45598664
102Insulin resistance_Homo sapiens_hsa049310.44893437
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43336944
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43020895
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.42637942
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42473243
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.42217886
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42153991
109FoxO signaling pathway_Homo sapiens_hsa040680.41823938
110Glutathione metabolism_Homo sapiens_hsa004800.41089105
111Pancreatic secretion_Homo sapiens_hsa049720.38949404
112Nitrogen metabolism_Homo sapiens_hsa009100.37100233
113Galactose metabolism_Homo sapiens_hsa000520.37060807
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35439427
115Ras signaling pathway_Homo sapiens_hsa040140.35344367
116Insulin signaling pathway_Homo sapiens_hsa049100.34788288
117AMPK signaling pathway_Homo sapiens_hsa041520.34732152
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33456067
119Cell cycle_Homo sapiens_hsa041100.31883055
120Inositol phosphate metabolism_Homo sapiens_hsa005620.29111257

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