ITCH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.46112936
2COPII vesicle coating (GO:0048208)4.37436713
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.14156041
4L-phenylalanine catabolic process (GO:0006559)4.14156041
5nuclear pore organization (GO:0006999)4.04491903
6cell adhesion mediated by integrin (GO:0033627)3.96102916
7cellular response to ethanol (GO:0071361)3.62233373
8aromatic amino acid family catabolic process (GO:0009074)3.57146279
9UDP-N-acetylglucosamine metabolic process (GO:0006047)3.55190455
10hepatocyte apoptotic process (GO:0097284)3.53244470
11desmosome organization (GO:0002934)3.50634326
12growth hormone receptor signaling pathway (GO:0060396)3.42949250
13pore complex assembly (GO:0046931)3.40710541
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36939868
15L-phenylalanine metabolic process (GO:0006558)3.36939868
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.31770166
17tryptophan metabolic process (GO:0006568)3.24854704
18tryptophan catabolic process (GO:0006569)3.24827795
19indole-containing compound catabolic process (GO:0042436)3.24827795
20indolalkylamine catabolic process (GO:0046218)3.24827795
21hemidesmosome assembly (GO:0031581)3.23968395
22regulation of transforming growth factor beta2 production (GO:0032909)3.21436987
23negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.15094066
24regulation of bile acid biosynthetic process (GO:0070857)3.14454958
25import into cell (GO:0098657)3.08472661
26detection of molecule of bacterial origin (GO:0032490)2.95997094
27embryonic retina morphogenesis in camera-type eye (GO:0060059)2.92695801
28regulation of Rac protein signal transduction (GO:0035020)2.91412289
29peptidyl-glutamic acid carboxylation (GO:0017187)2.90643469
30protein carboxylation (GO:0018214)2.90643469
31cellular response to growth hormone stimulus (GO:0071378)2.88398440
32alpha-linolenic acid metabolic process (GO:0036109)2.86543333
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86119855
34complement activation, alternative pathway (GO:0006957)2.86035480
35hypotonic response (GO:0006971)2.84871459
36iron ion import (GO:0097286)2.84400573
37regulation of alkaline phosphatase activity (GO:0010692)2.84351290
38intestinal epithelial cell development (GO:0060576)2.84007961
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82038972
40positive regulation of mitotic sister chromatid separation (GO:1901970)2.80723264
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80723264
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80723264
43axon ensheathment in central nervous system (GO:0032291)2.79951411
44central nervous system myelination (GO:0022010)2.79951411
45urea cycle (GO:0000050)2.78385521
46urea metabolic process (GO:0019627)2.78385521
47response to interleukin-15 (GO:0070672)2.76804985
48fibroblast migration (GO:0010761)2.76277289
49membrane raft organization (GO:0031579)2.74643994
50very-low-density lipoprotein particle assembly (GO:0034379)2.73534749
51cellular glucuronidation (GO:0052695)2.73365609
52protein localization to endosome (GO:0036010)2.70876474
53phospholipid homeostasis (GO:0055091)2.69859972
54tyrosine metabolic process (GO:0006570)2.68629106
55Golgi to endosome transport (GO:0006895)2.66279960
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63926456
57cysteine metabolic process (GO:0006534)2.61371758
58regulation of protein activation cascade (GO:2000257)2.61237993
59kynurenine metabolic process (GO:0070189)2.59636497
60negative regulation of protein activation cascade (GO:2000258)2.59277445
61regulation of metalloenzyme activity (GO:0048552)2.58951236
62negative regulation of keratinocyte proliferation (GO:0010839)2.57104793
63homocysteine metabolic process (GO:0050667)2.56268242
64embryonic process involved in female pregnancy (GO:0060136)2.56093582
65negative regulation of fibrinolysis (GO:0051918)2.55811321
66bile acid biosynthetic process (GO:0006699)2.54282504
67bile acid metabolic process (GO:0008206)2.54171767
68genitalia morphogenesis (GO:0035112)2.52582622
69vesicle coating (GO:0006901)2.52405903
70regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.51552626
71positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.51552626
72valine metabolic process (GO:0006573)2.51301554
73positive regulation of toll-like receptor signaling pathway (GO:0034123)2.50872538
74monoubiquitinated protein deubiquitination (GO:0035520)2.50692249
75regulation of complement activation (GO:0030449)2.50656448
76regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49869019
77positive regulation of cellular amide metabolic process (GO:0034250)2.49465317
78cellular biogenic amine catabolic process (GO:0042402)2.49308797
79amine catabolic process (GO:0009310)2.49308797
80positive regulation of protein autophosphorylation (GO:0031954)2.48526239
81plasma lipoprotein particle assembly (GO:0034377)2.47276059
82protein-lipid complex assembly (GO:0065005)2.47273096
83positive regulation of fatty acid beta-oxidation (GO:0032000)2.46141939
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.45997656
85necroptotic process (GO:0070266)2.45852148
86positive regulation of macroautophagy (GO:0016239)2.45816108
87midgut development (GO:0007494)2.45703707
88positive regulation of glycoprotein biosynthetic process (GO:0010560)2.45173395
89cholesterol efflux (GO:0033344)2.44757095
90early endosome to late endosome transport (GO:0045022)2.43946821
91nitrogen cycle metabolic process (GO:0071941)2.42380818
92phospholipid translocation (GO:0045332)2.40484480
93lipid translocation (GO:0034204)2.40484480
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39842218
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38888840
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.38888840
97regulation of translation, ncRNA-mediated (GO:0045974)2.38888840
98negative regulation of complement activation (GO:0045916)2.38860157
99aromatic amino acid family metabolic process (GO:0009072)2.37850180
100regulation of triglyceride catabolic process (GO:0010896)2.37670954
101cell wall macromolecule catabolic process (GO:0016998)2.37537348
102regulation of transforming growth factor beta1 production (GO:0032908)2.36691801
103response to lipoprotein particle (GO:0055094)2.35723298
104mesodermal cell differentiation (GO:0048333)2.34722834
105positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.34115849
106regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.34115849
107regulation of fibrinolysis (GO:0051917)2.33961612
108positive regulation of muscle hypertrophy (GO:0014742)2.32672913
109positive regulation of cardiac muscle hypertrophy (GO:0010613)2.32672913
110positive regulation of smooth muscle cell migration (GO:0014911)2.32264767
111macroautophagy (GO:0016236)2.31895575
112mitotic sister chromatid cohesion (GO:0007064)2.31582017
113urate metabolic process (GO:0046415)2.30885264
114pathway-restricted SMAD protein phosphorylation (GO:0060389)2.30801979
115cellular response to interleukin-15 (GO:0071350)2.30705912
116neutrophil activation involved in immune response (GO:0002283)2.30590717
117positive regulation of glycolytic process (GO:0045821)2.30415446
118regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28133772
119positive regulation of blood coagulation (GO:0030194)2.27395725
120positive regulation of hemostasis (GO:1900048)2.27395725
121glucuronate metabolic process (GO:0019585)2.27316298
122uronic acid metabolic process (GO:0006063)2.27316298
123indolalkylamine metabolic process (GO:0006586)2.27194477
124cellular response to cholesterol (GO:0071397)2.26906301
125COPI coating of Golgi vesicle (GO:0048205)2.26899730
126Golgi transport vesicle coating (GO:0048200)2.26899730
127positive regulation of coagulation (GO:0050820)2.26689888
128glyoxylate metabolic process (GO:0046487)2.26509373
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26060568
130plasma lipoprotein particle clearance (GO:0034381)2.25780928
131positive regulation of interferon-alpha production (GO:0032727)2.25695833
132regulation of interferon-beta biosynthetic process (GO:0045357)2.25612084
133regulation of protein polyubiquitination (GO:1902914)2.25440586
134ethanol oxidation (GO:0006069)2.25115064
135ER overload response (GO:0006983)2.24654305
136phospholipid efflux (GO:0033700)2.24546137
137bile acid and bile salt transport (GO:0015721)2.23989297
138regulation of extracellular matrix disassembly (GO:0010715)2.23824769
139I-kappaB phosphorylation (GO:0007252)2.23546021
140fatty acid elongation (GO:0030497)2.23413314
141pericardium development (GO:0060039)2.22930049
142cell wall macromolecule metabolic process (GO:0044036)2.21493885
143platelet-derived growth factor receptor signaling pathway (GO:0048008)2.20942117
144prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.20838119
145protein targeting to lysosome (GO:0006622)2.20517185
146establishment of protein localization to vacuole (GO:0072666)2.20517185
147protein targeting to vacuole (GO:0006623)2.20517185
148neutrophil activation (GO:0042119)2.19487006
149myelin assembly (GO:0032288)2.19362117
150response to cholesterol (GO:0070723)2.19230158
151drug transmembrane transport (GO:0006855)2.18733650
152linoleic acid metabolic process (GO:0043651)2.18430456
153cytoplasmic mRNA processing body assembly (GO:0033962)2.18198202
154positive regulation of lipid catabolic process (GO:0050996)2.16721133
155response to phenylpropanoid (GO:0080184)2.16435027
156regulation of keratinocyte differentiation (GO:0045616)2.15919313
157production of molecular mediator involved in inflammatory response (GO:0002532)2.15818459
158reverse cholesterol transport (GO:0043691)2.15717215
159regulation of transforming growth factor beta production (GO:0071634)2.15276442
160sterol homeostasis (GO:0055092)2.14842879
161cholesterol homeostasis (GO:0042632)2.14731040
162cellular response to sterol (GO:0036315)2.14613404
163purine ribonucleotide transport (GO:0015868)2.14555698
164NLS-bearing protein import into nucleus (GO:0006607)2.14467829
165establishment of protein localization to Golgi (GO:0072600)2.13945592
166positive regulation by symbiont of host defense response (GO:0052509)2.13767125
167modulation by symbiont of host defense response (GO:0052031)2.13767125
168modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13767125
169modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13767125
170positive regulation by organism of defense response of other organism involved in symbiotic interact2.13767125
171modulation by symbiont of host immune response (GO:0052553)2.13767125
172interleukin-6-mediated signaling pathway (GO:0070102)2.13632300
173protein K11-linked deubiquitination (GO:0035871)2.13401588
174positive regulation of lipoprotein lipase activity (GO:0051006)2.13352056
175positive regulation of triglyceride lipase activity (GO:0061365)2.13352056
176negative regulation of T-helper cell differentiation (GO:0045623)2.12648020
177negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.12648020
178positive regulation of fibroblast migration (GO:0010763)2.12065510
179regulation of interferon-alpha production (GO:0032647)2.11322571
180regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.11077391
181negative regulation of TOR signaling (GO:0032007)2.10729762
182wound healing, spreading of epidermal cells (GO:0035313)2.10056277
183Golgi organization (GO:0007030)2.09468220
184mammary gland epithelial cell proliferation (GO:0033598)2.09428763
185positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.08599343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38391043
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02804379
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.89406416
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66395300
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.53627796
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.48187295
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.39359477
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.25980253
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19156302
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.18803122
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07726640
12IRF8_27001747_Chip-Seq_BMDM_Mouse1.96326334
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95922864
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.95855990
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88993639
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88049282
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87974179
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86928522
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85667259
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85623079
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85526884
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82034575
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79453513
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78830682
25RUNX_20019798_ChIP-Seq_JUKART_Human1.76535335
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76407922
27BRD4_25478319_ChIP-Seq_HGPS_Human1.69933485
28GATA1_22025678_ChIP-Seq_K562_Human1.66733600
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66425938
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66303639
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.57709822
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53051554
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53051554
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51987300
35TP53_16413492_ChIP-PET_HCT116_Human1.51084794
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50112012
37* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49526123
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47883312
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.44147179
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.43510435
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41163031
42AHR_22903824_ChIP-Seq_MCF-7_Human1.40786688
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40058941
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.39889680
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37989558
46VDR_24787735_ChIP-Seq_THP-1_Human1.37943398
47GBX2_23144817_ChIP-Seq_PC3_Human1.37694257
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.36510916
49* TP63_23658742_ChIP-Seq_EP156T_Human1.35992601
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.35004083
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33847043
52RXR_22108803_ChIP-Seq_LS180_Human1.32893511
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32553670
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.32514065
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32349899
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30152399
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.28855548
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28518363
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26462416
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.26108834
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26107904
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24846232
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24374677
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23926550
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23414809
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20918610
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20668365
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20083776
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19871666
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18752762
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.18093090
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17623066
73* CJUN_26792858_Chip-Seq_BT549_Human1.17456913
74SMAD4_21799915_ChIP-Seq_A2780_Human1.17132492
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16947861
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16921468
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16265924
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.15022153
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14464785
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14460888
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13838886
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13657056
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.12871645
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12673265
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11856526
86* NMYC_18555785_Chip-Seq_ESCs_Mouse1.11268435
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.11268047
88* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11002997
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10688785
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10459401
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09884214
92* E2F1_18555785_Chip-Seq_ESCs_Mouse1.09411471
93SOX2_20726797_ChIP-Seq_SW620_Human1.09323732
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09229082
95TP53_18474530_ChIP-ChIP_U2OS_Human1.09075302
96* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08966988
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.08071910
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07761340
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07215933
100ER_23166858_ChIP-Seq_MCF-7_Human1.06607238
101* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05889593
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05888524
103* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05644228
104FUS_26573619_Chip-Seq_HEK293_Human1.05305231
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05196634
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04467025
107* P300_18555785_Chip-Seq_ESCs_Mouse1.04261119
108CDX2_22108803_ChIP-Seq_LS180_Human1.03631890
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02128231
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02128231
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02052880
112* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01536651
113TP63_17297297_ChIP-ChIP_HaCaT_Human1.01359377
114* STAT3_23295773_ChIP-Seq_U87_Human1.01089304
115TAF15_26573619_Chip-Seq_HEK293_Human1.00894037
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.00861440
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00735649
118* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.00468492
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00060795
120P300_19829295_ChIP-Seq_ESCs_Human0.99920908
121P53_22387025_ChIP-Seq_ESCs_Mouse0.99732414
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99176335
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.98431293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.15987750
2MP0005360_urolithiasis3.91606898
3MP0010352_gastrointestinal_tract_polyps3.35290865
4MP0005365_abnormal_bile_salt3.31118058
5MP0003252_abnormal_bile_duct3.30584255
6MP0002138_abnormal_hepatobiliary_system3.09355791
7MP0008057_abnormal_DNA_replication2.91918085
8MP0005085_abnormal_gallbladder_physiolo2.85446496
9MP0006054_spinal_hemorrhage2.85393767
10MP0008875_abnormal_xenobiotic_pharmacok2.61173932
11MP0003806_abnormal_nucleotide_metabolis2.55242168
12MP0003300_gastrointestinal_ulcer2.50509269
13MP0004019_abnormal_vitamin_homeostasis2.37018877
14MP0000569_abnormal_digit_pigmentation2.22957034
15MP0003950_abnormal_plasma_membrane2.22904105
16MP0002877_abnormal_melanocyte_morpholog2.18078335
17MP0009780_abnormal_chondrocyte_physiolo2.08732966
18MP0010678_abnormal_skin_adnexa1.96668624
19MP0003690_abnormal_glial_cell1.96039289
20MP0001835_abnormal_antigen_presentation1.94915417
21MP0000383_abnormal_hair_follicle1.88373966
22MP0003566_abnormal_cell_adhesion1.77167341
23MP0003656_abnormal_erythrocyte_physiolo1.70853833
24MP0000920_abnormal_myelination1.69740938
25MP0005164_abnormal_response_to1.62604171
26MP0010329_abnormal_lipoprotein_level1.59372751
27MP0001666_abnormal_nutrient_absorption1.56892905
28MP0003868_abnormal_feces_composition1.54489041
29MP0001661_extended_life_span1.52709021
30MP0003828_pulmonary_edema1.47749637
31MP0004883_abnormal_blood_vessel1.47247095
32MP0002419_abnormal_innate_immunity1.45040595
33MP0005387_immune_system_phenotype1.44158095
34MP0001790_abnormal_immune_system1.44158095
35MP0005332_abnormal_amino_acid1.42692371
36MP0000566_synostosis1.42111632
37MP0005671_abnormal_response_to1.35215369
38MP0003045_fibrosis1.33976209
39MP0003183_abnormal_peptide_metabolism1.32595673
40MP0006082_CNS_inflammation1.30043002
41MP0002060_abnormal_skin_morphology1.29332829
42MP0005451_abnormal_body_composition1.28810179
43MP0000015_abnormal_ear_pigmentation1.26885952
44MP0005248_abnormal_Harderian_gland1.26727827
45MP0009697_abnormal_copulation1.26521869
46MP0002928_abnormal_bile_duct1.26426991
47MP0000013_abnormal_adipose_tissue1.25249022
48MP0000465_gastrointestinal_hemorrhage1.24996627
49MP0004272_abnormal_basement_membrane1.19329977
50MP0004264_abnormal_extraembryonic_tissu1.18566010
51MP0008438_abnormal_cutaneous_collagen1.15571990
52MP0001851_eye_inflammation1.15353029
53MP0009384_cardiac_valve_regurgitation1.13676345
54MP0002168_other_aberrant_phenotype1.12872488
55MP0010307_abnormal_tumor_latency1.12408011
56MP0001800_abnormal_humoral_immune1.11808870
57MP0003191_abnormal_cellular_cholesterol1.11641902
58MP0000609_abnormal_liver_physiology1.11611626
59MP0004484_altered_response_of1.11559372
60MP0002166_altered_tumor_susceptibility1.11412099
61MP0005275_abnormal_skin_tensile1.11066690
62MP0000003_abnormal_adipose_tissue1.11062649
63MP0002452_abnormal_antigen_presenting1.10666394
64MP0003763_abnormal_thymus_physiology1.10386598
65MP0003195_calcinosis1.08342193
66* MP0001216_abnormal_epidermal_layer1.07902817
67MP0002118_abnormal_lipid_homeostasis1.07299549
68MP0003705_abnormal_hypodermis_morpholog1.06617647
69MP0009764_decreased_sensitivity_to1.06181454
70MP0009643_abnormal_urine_homeostasis1.04714240
71MP0002933_joint_inflammation1.04282973
72MP0005670_abnormal_white_adipose1.03848855
73MP0005058_abnormal_lysosome_morphology1.02890239
74MP0003172_abnormal_lysosome_physiology1.02878464
75MP0005408_hypopigmentation1.02258661
76MP0002396_abnormal_hematopoietic_system1.01500900
77MP0010234_abnormal_vibrissa_follicle1.00908408
78MP0003453_abnormal_keratinocyte_physiol0.99833063
79MP0001958_emphysema0.99175060
80MP0009763_increased_sensitivity_to0.96357009
81MP0002998_abnormal_bone_remodeling0.96109245
82MP0002723_abnormal_immune_serum0.91619468
83MP0002136_abnormal_kidney_physiology0.90245848
84MP0005000_abnormal_immune_tolerance0.90006082
85MP0004381_abnormal_hair_follicle0.89961175
86MP0009115_abnormal_fat_cell0.89167902
87MP0009765_abnormal_xenobiotic_induced0.88333734
88MP0000627_abnormal_mammary_gland0.88043848
89MP0003724_increased_susceptibility_to0.88026986
90MP0003943_abnormal_hepatobiliary_system0.87879191
91MP0009840_abnormal_foam_cell0.87620551
92MP0005023_abnormal_wound_healing0.87245505
93MP0010368_abnormal_lymphatic_system0.86489570
94MP0004947_skin_inflammation0.85104098
95MP0005171_absent_coat_pigmentation0.84785288
96MP0003436_decreased_susceptibility_to0.84358327
97MP0002420_abnormal_adaptive_immunity0.84142684
98MP0001819_abnormal_immune_cell0.84113587
99MP0001177_atelectasis0.84036007
100MP0005025_abnormal_response_to0.83729600
101MP0001533_abnormal_skeleton_physiology0.82718861
102MP0010155_abnormal_intestine_physiology0.82717753
103MP0005464_abnormal_platelet_physiology0.81713845
104MP0000371_diluted_coat_color0.81504273
105MP0003448_altered_tumor_morphology0.81423545
106MP0000462_abnormal_digestive_system0.80527715
107MP0002086_abnormal_extraembryonic_tissu0.79842897
108MP0001915_intracranial_hemorrhage0.79178514
109MP0002009_preneoplasia0.78739058
110MP0002006_tumorigenesis0.78454125
111MP0008260_abnormal_autophagy0.78089173
112MP0004134_abnormal_chest_morphology0.77660687
113* MP0001845_abnormal_inflammatory_respons0.77326234
114MP0002132_abnormal_respiratory_system0.76767521
115MP0002254_reproductive_system_inflammat0.75244087
116MP0000604_amyloidosis0.75133493
117MP0001191_abnormal_skin_condition0.72683775
118MP0004808_abnormal_hematopoietic_stem0.72044210
119MP0003091_abnormal_cell_migration0.72022614
120MP0002896_abnormal_bone_mineralization0.71850821
121MP0003632_abnormal_nervous_system0.71219022
122MP0005220_abnormal_exocrine_pancreas0.70787480
123MP0005503_abnormal_tendon_morphology0.70684969
124MP0005076_abnormal_cell_differentiation0.70653058
125MP0003303_peritoneal_inflammation0.70601773
126MP0000377_abnormal_hair_follicle0.69743052
127MP0008469_abnormal_protein_level0.69483500
128MP0000427_abnormal_hair_cycle0.69098529
129MP0003937_abnormal_limbs/digits/tail_de0.68561158
130MP0005334_abnormal_fat_pad0.68086024
131MP0009785_altered_susceptibility_to0.67119158
132MP0000647_abnormal_sebaceous_gland0.67114054
133MP0001879_abnormal_lymphatic_vessel0.66992647
134MP0000598_abnormal_liver_morphology0.66954070
135MP0005621_abnormal_cell_physiology0.66620236
136MP0001853_heart_inflammation0.66403579
137MP0002332_abnormal_exercise_endurance0.66006278
138MP0005375_adipose_tissue_phenotype0.64045710
139MP0005376_homeostasis/metabolism_phenot0.62832541
140MP0003221_abnormal_cardiomyocyte_apopto0.62557337
141* MP0002405_respiratory_system_inflammati0.58816669

Predicted human phenotypes

RankGene SetZ-score
1Subacute progressive viral hepatitis (HP:0006572)3.63471086
2Papillary thyroid carcinoma (HP:0002895)3.56486136
3Intrahepatic cholestasis (HP:0001406)3.18154662
4Curly hair (HP:0002212)3.11851287
5Autoimmune hemolytic anemia (HP:0001890)2.99138949
6Hematochezia (HP:0002573)2.88258158
7Abnormality of methionine metabolism (HP:0010901)2.87748722
8Stomach cancer (HP:0012126)2.84624891
9Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76491924
10Hyperlipoproteinemia (HP:0010980)2.66137265
11Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65916635
12Ankyloglossia (HP:0010296)2.65268696
13Abnormality of sulfur amino acid metabolism (HP:0004339)2.65099964
14Complement deficiency (HP:0004431)2.63690778
15Abnormality of incisor morphology (HP:0011063)2.63088603
16Arterial tortuosity (HP:0005116)2.62525867
17Deep venous thrombosis (HP:0002625)2.61484888
18Enlarged kidneys (HP:0000105)2.58142988
19Hypolipoproteinemia (HP:0010981)2.56086921
20Recurrent gram-negative bacterial infections (HP:0005420)2.54242632
21Cutaneous melanoma (HP:0012056)2.50551914
22Prolonged partial thromboplastin time (HP:0003645)2.49965568
23Thyroid carcinoma (HP:0002890)2.49640278
24Myocardial infarction (HP:0001658)2.48597715
25Sensory axonal neuropathy (HP:0003390)2.48295483
26Abnormality of oral frenula (HP:0000190)2.47752492
27Epidermoid cyst (HP:0200040)2.46895012
28Xanthomatosis (HP:0000991)2.42426370
29Vascular calcification (HP:0004934)2.41704348
30Generalized hypopigmentation of hair (HP:0011358)2.37608521
31Osteolytic defects of the hand bones (HP:0009699)2.36610103
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.36610103
33Cardiovascular calcification (HP:0011915)2.35500205
34Abnormality of the common coagulation pathway (HP:0010990)2.34502811
35Hypochromic microcytic anemia (HP:0004840)2.33668368
36Abnormal foot bone ossification (HP:0010675)2.32646015
37Abnormality of the nasal septum (HP:0000419)2.30433870
38Fat malabsorption (HP:0002630)2.29048883
39Eczematoid dermatitis (HP:0000976)2.26979538
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26883652
41* Chronic diarrhea (HP:0002028)2.26211467
42Submucous cleft hard palate (HP:0000176)2.25439807
43Tetraparesis (HP:0002273)2.23803839
44Hypoglycemic seizures (HP:0002173)2.23050218
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22232234
46Fair hair (HP:0002286)2.21544419
47Joint hemorrhage (HP:0005261)2.21523658
48Coarse hair (HP:0002208)2.19373008
49Hypoplastic ischia (HP:0003175)2.19170120
50Conjugated hyperbilirubinemia (HP:0002908)2.18758080
51Vascular tortuosity (HP:0004948)2.17290786
52Renal cortical cysts (HP:0000803)2.16868336
53Bell-shaped thorax (HP:0001591)2.16527834
54Symptomatic seizures (HP:0011145)2.14510740
55Hypoplastic labia majora (HP:0000059)2.12365456
56Systemic lupus erythematosus (HP:0002725)2.11671535
57Hyperglycemia (HP:0003074)2.11390235
58Heterotopia (HP:0002282)2.11247181
59Glomerulonephritis (HP:0000099)2.11219817
60Asymmetry of the thorax (HP:0001555)2.10654427
61Abnormal auditory evoked potentials (HP:0006958)2.09084605
62Glucose intolerance (HP:0000833)2.08730083
63Neoplasm of the adrenal cortex (HP:0100641)2.07435339
64Alopecia of scalp (HP:0002293)2.07406270
65Abnormality of the fingertips (HP:0001211)2.05864083
66Recurrent bacterial skin infections (HP:0005406)2.05492205
67Gingival bleeding (HP:0000225)2.04551494
68Abnormality of the ischium (HP:0003174)2.04294654
69Transitional cell carcinoma of the bladder (HP:0006740)2.03786634
70Homocystinuria (HP:0002156)2.03529221
71Abnormality of homocysteine metabolism (HP:0010919)2.03529221
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01259706
73Vitreoretinal degeneration (HP:0000655)2.01117092
74Freckling (HP:0001480)2.00117244
75Aortic dissection (HP:0002647)1.98856048
76Menstrual irregularities (HP:0000858)1.98526840
77Hypoalphalipoproteinemia (HP:0003233)1.98142530
78Bladder neoplasm (HP:0009725)1.98114951
79Bladder carcinoma (HP:0002862)1.98114951
80Milia (HP:0001056)1.97284795
81Abnormality of complement system (HP:0005339)1.97192511
82Micronodular cirrhosis (HP:0001413)1.96729719
83Hamartoma of the eye (HP:0010568)1.96315522
84Ectropion (HP:0000656)1.95234349
85Spondylolisthesis (HP:0003302)1.94641483
86Plantar hyperkeratosis (HP:0007556)1.94580501
87Steatorrhea (HP:0002570)1.93449297
88Abnormality of the labia majora (HP:0012881)1.92447881
89Abnormality of macrophages (HP:0004311)1.92132895
90Gingivitis (HP:0000230)1.90631261
91Recurrent abscess formation (HP:0002722)1.90624253
92Albinism (HP:0001022)1.89240748
93Abnormal biliary tract morphology (HP:0012440)1.88585025
94Right ventricular cardiomyopathy (HP:0011663)1.88345835
95Metabolic alkalosis (HP:0200114)1.87811642
96Absent frontal sinuses (HP:0002688)1.86463855
97Blepharitis (HP:0000498)1.86278589
98Volvulus (HP:0002580)1.86072435
99Mitral stenosis (HP:0001718)1.84630167
100Periodontitis (HP:0000704)1.84127976
101Epiphyseal dysplasia (HP:0002656)1.82733816
102Abnormality of the renal cortex (HP:0011035)1.82123506
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81702928
104Thyroiditis (HP:0100646)1.80282918
105Bilateral sensorineural hearing impairment (HP:0008619)1.79539611
106Scanning speech (HP:0002168)1.79434053
107T lymphocytopenia (HP:0005403)1.79250991
108Cubitus valgus (HP:0002967)1.78599910
109Increased CSF protein (HP:0002922)1.76609558
110Chronic hepatic failure (HP:0100626)1.76478770
111Small epiphyses (HP:0010585)1.76029250
112Atrophic scars (HP:0001075)1.75682271
113Limited elbow extension (HP:0001377)1.74367058
114Anteriorly placed anus (HP:0001545)1.73735130
115Abnormal glucose tolerance (HP:0001952)1.73476714
116Cystic hygroma (HP:0000476)1.73277829
117Palmar hyperkeratosis (HP:0010765)1.73196450
118Proximal tubulopathy (HP:0000114)1.72726049
119Hypercholesterolemia (HP:0003124)1.72472703
120Vacuolated lymphocytes (HP:0001922)1.72411060
121Onycholysis (HP:0001806)1.70364454
122White forelock (HP:0002211)1.70254974
123Increased mean platelet volume (HP:0011877)1.69664890
124Arterial thrombosis (HP:0004420)1.68487382
125Esophageal varix (HP:0002040)1.67380111
126Abnormality of T cell number (HP:0011839)1.66292937
127Aqueductal stenosis (HP:0002410)1.66274934
128Gastrointestinal infarctions (HP:0005244)1.66104137
129Orchitis (HP:0100796)1.65980130
130Recurrent skin infections (HP:0001581)1.65831915
131Thick nail (HP:0001805)1.65429856
132Syringomyelia (HP:0003396)1.65335845
133Spinal cord lesions (HP:0100561)1.65335845
134Portal hypertension (HP:0001409)1.65192508
135Hydroxyprolinuria (HP:0003080)1.64548199
136Abnormality of proline metabolism (HP:0010907)1.64548199
137Somatic mutation (HP:0001428)1.64388872
138Hypobetalipoproteinemia (HP:0003563)1.63502680
139Cone-rod dystrophy (HP:0000548)1.62896772
140Eosinophilia (HP:0001880)1.62571013
141Pulmonic stenosis (HP:0001642)1.62300335
142Deep philtrum (HP:0002002)1.61968596
143Pustule (HP:0200039)1.61685895
144Macroorchidism (HP:0000053)1.61103276
145Abnormal platelet volume (HP:0011876)1.60889724
146Prostate neoplasm (HP:0100787)1.59618187
147Hepatocellular carcinoma (HP:0001402)1.58714828
148Neoplasm of the tracheobronchial system (HP:0100552)1.57941840
149Optic neuritis (HP:0100653)1.57850663
150Retrobulbar optic neuritis (HP:0100654)1.57850663
151Patchy hypopigmentation of hair (HP:0011365)1.57603804
152Acute myeloid leukemia (HP:0004808)1.57489850
153Abnormality of the lumbar spine (HP:0100712)1.57347720
154Segmental peripheral demyelination/remyelination (HP:0003481)1.57199052
155Recurrent fungal infections (HP:0002841)1.57153494
156Pigmentary retinal degeneration (HP:0001146)1.56730693
157Confusion (HP:0001289)1.56583989
158Abnormality of chloride homeostasis (HP:0011422)1.56424378
159Disproportionate tall stature (HP:0001519)1.56279901
160Clitoromegaly (HP:0000057)1.56045182
161Chorioretinal atrophy (HP:0000533)1.55706252
162Abnormality of the hepatic vasculature (HP:0006707)1.54571875
163Abnormal hand bone ossification (HP:0010660)1.54413062
164Progressive visual loss (HP:0000529)1.53169564
165Bifid scrotum (HP:0000048)1.52173200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.34521967
2TXK2.74871451
3EPHB12.69871906
4INSRR2.68051637
5EIF2AK32.60874985
6LATS12.59345617
7FGFR22.45151611
8STK392.39762565
9ZAK2.36677666
10MAP3K22.29262064
11ERBB32.26309913
12SIK12.25597613
13NUAK12.20737821
14IRAK32.18582530
15NEK92.11299291
16BMPR21.99364943
17EIF2AK11.86189772
18ACVR1B1.83351680
19OXSR11.79375304
20EPHA31.78364288
21KSR11.74129817
22MAP3K141.73756787
23JAK11.71000903
24STK31.69247630
25MKNK21.68028614
26IRAK41.64305174
27NEK61.63224083
28STK101.56543471
29FGFR41.55917905
30MST41.55395196
31BRD41.53267253
32TAOK31.50581095
33BRSK21.49936641
34TRIM281.47262213
35PBK1.46408752
36MAP3K121.44903325
37KSR21.43369844
38WNK11.43299571
39CAMK1D1.43229409
40CSNK1A1L1.42528321
41FGFR31.39354286
42PDK21.38532866
43MAP4K11.38381895
44SCYL21.32482257
45MAP3K91.30368705
46MET1.30129995
47FER1.28590656
48TYK21.26310415
49PLK21.23351252
50PIK3CA1.23066528
51SGK21.20312535
52CDK61.17259028
53CAMK1G1.16972430
54TRPM71.14548728
55STK381.13521439
56ITK1.12939867
57MAP3K131.10618352
58CDK121.09372272
59RAF11.09092692
60CAMKK21.09000256
61SGK4941.08958807
62SGK2231.08958807
63MAP3K31.04026662
64AKT31.02151351
65CSK1.01291742
66MKNK11.00002721
67MAPK70.97565114
68PDGFRB0.97228853
69CLK10.97202389
70STK40.94118376
71PAK30.93669262
72PDGFRA0.93329021
73TGFBR20.90339644
74CSF1R0.89950710
75PRKCQ0.88412251
76TEC0.84707738
77IRAK10.80662105
78PLK40.79783921
79PKN10.79366433
80CHUK0.78917981
81* SGK30.77800064
82MARK30.75942888
83CSNK1G10.75938884
84FGR0.75447769
85BLK0.74393308
86JAK30.74229070
87ERBB40.74211585
88MST1R0.71836449
89IRAK20.71619152
90MELK0.70321631
91WNK40.69944746
92PTK60.69298370
93PTK20.67253786
94IKBKE0.66296634
95CDK90.66285448
96PRKAA20.65680152
97TNIK0.65626005
98IKBKB0.64817277
99GSK3A0.64724613
100BMPR1B0.64707997
101NLK0.62516299
102MAP2K10.62302301
103SIK30.59902318
104ABL10.58609053
105RET0.58090462
106IGF1R0.56865590
107MOS0.56332732
108STK240.55570630
109LCK0.55338828
110FGFR10.54535703
111ERBB20.53303931
112PDK10.50538545
113HIPK20.50534827
114ZAP700.50115388
115EPHA20.49307157
116YES10.48690763
117BTK0.48589101
118HCK0.48567189
119LYN0.47868489
120RPS6KB10.47389121
121GRK10.47323881
122EIF2AK20.47014502
123BCR0.46970671
124KIT0.46564789
125FLT30.45307199
126JAK20.44459291
127INSR0.44242517
128MAP3K10.43644593
129EGFR0.43422626
130CSNK1G30.43063981
131MAP3K70.42947184
132STK38L0.42580712
133RIPK10.42280121
134MAP2K30.42244613
135GRK70.41627622
136NEK10.41600370
137MAPK110.36567381
138RPS6KA50.36432300
139PDPK10.34374300
140PTK2B0.32105384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.89262950
2Staphylococcus aureus infection_Homo sapiens_hsa051502.50524843
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.48343719
4Complement and coagulation cascades_Homo sapiens_hsa046102.26212948
5Steroid biosynthesis_Homo sapiens_hsa001002.26198452
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05277240
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99428298
8Vitamin digestion and absorption_Homo sapiens_hsa049771.92135316
9Histidine metabolism_Homo sapiens_hsa003401.89226416
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80658834
11Sulfur metabolism_Homo sapiens_hsa009201.68666308
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68342043
13Lysine degradation_Homo sapiens_hsa003101.63128253
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63071468
15Chemical carcinogenesis_Homo sapiens_hsa052041.62037904
16Retinol metabolism_Homo sapiens_hsa008301.61439215
17Tryptophan metabolism_Homo sapiens_hsa003801.57347328
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55910223
19Arginine biosynthesis_Homo sapiens_hsa002201.52071202
20Peroxisome_Homo sapiens_hsa041461.50376852
21Fatty acid elongation_Homo sapiens_hsa000621.46535787
22Inositol phosphate metabolism_Homo sapiens_hsa005621.45902183
23Non-small cell lung cancer_Homo sapiens_hsa052231.44779800
24ABC transporters_Homo sapiens_hsa020101.44192028
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43983463
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.43469220
27Fatty acid degradation_Homo sapiens_hsa000711.43459725
28Pancreatic cancer_Homo sapiens_hsa052121.42187991
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39557386
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.38405797
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38056079
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36846665
33Chronic myeloid leukemia_Homo sapiens_hsa052201.34584396
34Proteoglycans in cancer_Homo sapiens_hsa052051.32793848
35PPAR signaling pathway_Homo sapiens_hsa033201.30243210
36Legionellosis_Homo sapiens_hsa051341.30086843
37Small cell lung cancer_Homo sapiens_hsa052221.30039833
38Renal cell carcinoma_Homo sapiens_hsa052111.27118105
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26782310
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.26026322
41Thyroid cancer_Homo sapiens_hsa052161.25538353
42beta-Alanine metabolism_Homo sapiens_hsa004101.23282074
43Glioma_Homo sapiens_hsa052141.18677934
44Selenocompound metabolism_Homo sapiens_hsa004501.17386159
45Non-homologous end-joining_Homo sapiens_hsa034501.16811853
46Fatty acid metabolism_Homo sapiens_hsa012121.16615912
47Endometrial cancer_Homo sapiens_hsa052131.14413260
48Caffeine metabolism_Homo sapiens_hsa002321.13142860
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09189750
50Hepatitis B_Homo sapiens_hsa051611.08740790
51mTOR signaling pathway_Homo sapiens_hsa041501.08239510
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.07621761
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07353507
54Prolactin signaling pathway_Homo sapiens_hsa049171.02811824
55Renin-angiotensin system_Homo sapiens_hsa046141.02654092
56Butanoate metabolism_Homo sapiens_hsa006501.02452640
57Focal adhesion_Homo sapiens_hsa045101.02123829
58Vitamin B6 metabolism_Homo sapiens_hsa007501.01403319
59Influenza A_Homo sapiens_hsa051640.97978741
60Starch and sucrose metabolism_Homo sapiens_hsa005000.97701913
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92981266
62African trypanosomiasis_Homo sapiens_hsa051430.92671324
63Tyrosine metabolism_Homo sapiens_hsa003500.92392901
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.92281486
65Bile secretion_Homo sapiens_hsa049760.91925417
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91807358
67Primary immunodeficiency_Homo sapiens_hsa053400.89152856
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87287137
69Amoebiasis_Homo sapiens_hsa051460.85228100
70* TNF signaling pathway_Homo sapiens_hsa046680.83316296
71ErbB signaling pathway_Homo sapiens_hsa040120.83302079
72Folate biosynthesis_Homo sapiens_hsa007900.80516678
73Shigellosis_Homo sapiens_hsa051310.80282849
74Malaria_Homo sapiens_hsa051440.79877500
75Tuberculosis_Homo sapiens_hsa051520.79690680
76Propanoate metabolism_Homo sapiens_hsa006400.79599361
77Phenylalanine metabolism_Homo sapiens_hsa003600.78709865
78Ether lipid metabolism_Homo sapiens_hsa005650.78283504
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.77935563
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.77815588
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77004112
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76817114
83Mineral absorption_Homo sapiens_hsa049780.76363108
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76169431
85Platelet activation_Homo sapiens_hsa046110.76167147
86Lysosome_Homo sapiens_hsa041420.75328817
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.75103815
88Osteoclast differentiation_Homo sapiens_hsa043800.72700935
89Leishmaniasis_Homo sapiens_hsa051400.72118618
90Hematopoietic cell lineage_Homo sapiens_hsa046400.71993061
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71529435
92ECM-receptor interaction_Homo sapiens_hsa045120.71057703
93Prostate cancer_Homo sapiens_hsa052150.70678155
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.69029876
95B cell receptor signaling pathway_Homo sapiens_hsa046620.68811224
96Fat digestion and absorption_Homo sapiens_hsa049750.68752013
97Sphingolipid metabolism_Homo sapiens_hsa006000.67983826
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64474219
99Glycerolipid metabolism_Homo sapiens_hsa005610.64116023
100Measles_Homo sapiens_hsa051620.64031519
101Autoimmune thyroid disease_Homo sapiens_hsa053200.63347950
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62649100
103Type II diabetes mellitus_Homo sapiens_hsa049300.62454446
104Adherens junction_Homo sapiens_hsa045200.61822537
105Acute myeloid leukemia_Homo sapiens_hsa052210.61496437
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61202073
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60345796
108Colorectal cancer_Homo sapiens_hsa052100.60274601
109Melanoma_Homo sapiens_hsa052180.60241129
110Pertussis_Homo sapiens_hsa051330.60196235
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60119833
112Apoptosis_Homo sapiens_hsa042100.60096721
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59407251
114Viral carcinogenesis_Homo sapiens_hsa052030.59302640
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58847397
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58501575
117Arginine and proline metabolism_Homo sapiens_hsa003300.57591220
118HIF-1 signaling pathway_Homo sapiens_hsa040660.57286375
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56419830
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56215156
121p53 signaling pathway_Homo sapiens_hsa041150.55818163
122Insulin signaling pathway_Homo sapiens_hsa049100.55662526
123Protein digestion and absorption_Homo sapiens_hsa049740.54847028
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.54004876
125T cell receptor signaling pathway_Homo sapiens_hsa046600.53030915
126Hepatitis C_Homo sapiens_hsa051600.52678890
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51233910
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48674791
129Circadian rhythm_Homo sapiens_hsa047100.48510699
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48190474
131Chemokine signaling pathway_Homo sapiens_hsa040620.48162403
132Glucagon signaling pathway_Homo sapiens_hsa049220.48036596
133Other glycan degradation_Homo sapiens_hsa005110.47649245
134Dorso-ventral axis formation_Homo sapiens_hsa043200.47443340
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.47305799
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.47004338
137Regulation of autophagy_Homo sapiens_hsa041400.46657583
138Toxoplasmosis_Homo sapiens_hsa051450.46585480
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46584643
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46471696
141Glutathione metabolism_Homo sapiens_hsa004800.46452038
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45458602
143Insulin resistance_Homo sapiens_hsa049310.45449857
144FoxO signaling pathway_Homo sapiens_hsa040680.44802861
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44431879
146Fatty acid biosynthesis_Homo sapiens_hsa000610.42984090
147MicroRNAs in cancer_Homo sapiens_hsa052060.41707951
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41273142
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41158164
150Systemic lupus erythematosus_Homo sapiens_hsa053220.36168899
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35878505
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35382820
153TGF-beta signaling pathway_Homo sapiens_hsa043500.34364193
154Herpes simplex infection_Homo sapiens_hsa051680.33972214

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