ISY1-RAB43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.11185078
2positive regulation of gamma-delta T cell activation (GO:0046645)3.98737114
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96482560
4negative regulation of cell killing (GO:0031342)3.96482560
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91449822
6antigen processing and presentation of endogenous antigen (GO:0019883)3.76898448
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70200648
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.70200648
9modulation by symbiont of host immune response (GO:0052553)3.70200648
10positive regulation by symbiont of host defense response (GO:0052509)3.70200648
11modulation by symbiont of host defense response (GO:0052031)3.70200648
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70200648
13negative regulation of erythrocyte differentiation (GO:0045647)3.68195723
14protein localization to endosome (GO:0036010)3.64002924
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63170558
16response to peptidoglycan (GO:0032494)3.37370399
17detection of other organism (GO:0098543)3.33030402
18pinocytosis (GO:0006907)3.16665369
19detection of bacterium (GO:0016045)3.16580068
20leukocyte aggregation (GO:0070486)3.10425687
21response to laminar fluid shear stress (GO:0034616)3.08183927
22Golgi transport vesicle coating (GO:0048200)3.06425737
23COPI coating of Golgi vesicle (GO:0048205)3.06425737
24macrophage activation involved in immune response (GO:0002281)2.97767675
25detection of molecule of bacterial origin (GO:0032490)2.97315847
26response to muramyl dipeptide (GO:0032495)2.97201558
27detection of external biotic stimulus (GO:0098581)2.94062706
28regulation of gamma-delta T cell activation (GO:0046643)2.93334144
29positive regulation of Cdc42 GTPase activity (GO:0043089)2.90622512
30negative regulation of interleukin-12 production (GO:0032695)2.85575095
31embryonic process involved in female pregnancy (GO:0060136)2.81882107
32neutrophil activation involved in immune response (GO:0002283)2.78530568
33hypotonic response (GO:0006971)2.77330501
34mannose metabolic process (GO:0006013)2.77315951
35lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77220427
36germinal center formation (GO:0002467)2.75237698
37barbed-end actin filament capping (GO:0051016)2.71465553
38cellular extravasation (GO:0045123)2.70956812
39stress fiber assembly (GO:0043149)2.69916174
40regulation of gamma-delta T cell differentiation (GO:0045586)2.67056130
41modulation by symbiont of host cellular process (GO:0044068)2.65968639
42response to interleukin-15 (GO:0070672)2.65871791
43regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64874686
44regulation of leukocyte degranulation (GO:0043300)2.64683398
45cellular response to type I interferon (GO:0071357)2.63513391
46type I interferon signaling pathway (GO:0060337)2.63513391
47regulation of T-helper 2 cell differentiation (GO:0045628)2.62530044
48NIK/NF-kappaB signaling (GO:0038061)2.61863884
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61416455
50response to type I interferon (GO:0034340)2.61086178
51regulation of T cell tolerance induction (GO:0002664)2.59739911
52antigen processing and presentation via MHC class Ib (GO:0002475)2.59011988
53regulation of interferon-beta biosynthetic process (GO:0045357)2.57637622
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56095450
55detection of biotic stimulus (GO:0009595)2.54699236
56epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53882675
57regulation of early endosome to late endosome transport (GO:2000641)2.53219787
58regulation of necroptotic process (GO:0060544)2.50967190
593-UTR-mediated mRNA stabilization (GO:0070935)2.49279018
60regulation of extracellular matrix disassembly (GO:0010715)2.48867975
61response to host (GO:0075136)2.48827017
62response to host defenses (GO:0052200)2.48827017
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48827017
64regulation of B cell receptor signaling pathway (GO:0050855)2.48526461
65positive regulation of cellular amide metabolic process (GO:0034250)2.48175930
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48065390
67thymic T cell selection (GO:0045061)2.47922390
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.46418099
69positive regulation of extracellular matrix organization (GO:1903055)2.46323372
70positive thymic T cell selection (GO:0045059)2.46158681
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45741591
72regulation of tolerance induction (GO:0002643)2.44355198
73regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44095591
74myeloid dendritic cell differentiation (GO:0043011)2.43941718
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41097590
76skin morphogenesis (GO:0043589)2.40615737
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.38275489
78regulation of mast cell degranulation (GO:0043304)2.36534256
79negative thymic T cell selection (GO:0045060)2.36514365
80negative regulation of toll-like receptor signaling pathway (GO:0034122)2.36441062
81negative regulation of leukocyte mediated immunity (GO:0002704)2.34376979
82regulation of defense response to virus by virus (GO:0050690)2.33745164
83response to host immune response (GO:0052572)2.33068419
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33068419
85tolerance induction (GO:0002507)2.28814831
86production of molecular mediator involved in inflammatory response (GO:0002532)2.28600949
87pentose-phosphate shunt (GO:0006098)2.28464121
88focal adhesion assembly (GO:0048041)2.28382208
89cell-substrate adherens junction assembly (GO:0007045)2.28382208
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27904056
91T cell selection (GO:0045058)2.26326763
92cell-substrate junction assembly (GO:0007044)2.26185367
93negative regulation of type 2 immune response (GO:0002829)2.25205470
94negative T cell selection (GO:0043383)2.24132441
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.24110877
96B cell receptor signaling pathway (GO:0050853)2.23982270
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23287281
98histone H3-K36 demethylation (GO:0070544)2.21682215
99modulation by virus of host process (GO:0019054)2.20461870
100positive regulation of tolerance induction (GO:0002645)2.19556345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.54251712
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.27738460
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.00707309
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.71866548
5MYC_22102868_ChIP-Seq_BL_Human2.64416898
6VDR_21846776_ChIP-Seq_THP-1_Human2.47856781
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.44880977
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34818172
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.33659599
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30502749
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22253917
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19801101
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19629077
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19009680
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18779471
16TCF7_22412390_ChIP-Seq_EML_Mouse2.17667396
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12190433
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09641166
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02130568
20LXR_22292898_ChIP-Seq_THP-1_Human1.95510179
21VDR_24763502_ChIP-Seq_THP-1_Human1.92058188
22MAF_26560356_Chip-Seq_TH1_Human1.91304470
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87259709
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86934735
25CLOCK_20551151_ChIP-Seq_293T_Human1.85339252
26KDM2B_26808549_Chip-Seq_DND41_Human1.85123708
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.77936541
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.77186320
29RACK7_27058665_Chip-Seq_MCF-7_Human1.75069263
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.71955018
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70065041
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.69365826
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65161648
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63099955
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61152983
36UTX_26944678_Chip-Seq_JUKART_Human1.59249357
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58916913
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55824822
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55555977
40SPI1_23127762_ChIP-Seq_K562_Human1.53736472
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53141773
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51835471
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50556720
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50483950
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49740926
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.49506808
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45247544
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44181838
49SPI1_23547873_ChIP-Seq_NB4_Human1.42094738
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42009353
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42004444
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38462975
53MAF_26560356_Chip-Seq_TH2_Human1.37645720
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37280415
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37075847
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.35918380
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35253649
58RUNX_20019798_ChIP-Seq_JUKART_Human1.34221670
59KDM2B_26808549_Chip-Seq_K562_Human1.32450139
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31739815
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30385870
62MYB_26560356_Chip-Seq_TH1_Human1.29271148
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27900764
64MYB_26560356_Chip-Seq_TH2_Human1.23707855
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22918556
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.22783400
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20671573
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.19989875
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19985129
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19541076
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18538421
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18106905
73NCOR1_26117541_ChIP-Seq_K562_Human1.17867346
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16685644
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.14973295
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14095922
77ZNF263_19887448_ChIP-Seq_K562_Human1.13702694
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12786765
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11653058
80ATF3_27146783_Chip-Seq_COLON_Human1.10298508
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09921070
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09698488
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09340988
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08924660
85SCL_19346495_ChIP-Seq_HPC-7_Human1.08661177
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08660324
87GATA1_19941826_ChIP-Seq_K562_Human1.08613269
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07673921
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05038185
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04612153
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03970782
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03052510
93PU_27001747_Chip-Seq_BMDM_Mouse1.02756958
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01229962
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00665618
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97652818
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97652818
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.97044493
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96554520
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.94080409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.27295970
2MP0003705_abnormal_hypodermis_morpholog3.18523222
3MP0003436_decreased_susceptibility_to3.17737003
4MP0003300_gastrointestinal_ulcer3.02328928
5MP0005451_abnormal_body_composition2.81436638
6MP0003191_abnormal_cellular_cholesterol2.53071875
7MP0003724_increased_susceptibility_to2.52007132
8MP0005058_abnormal_lysosome_morphology2.41547502
9MP0003566_abnormal_cell_adhesion2.37961162
10MP0008260_abnormal_autophagy2.27559735
11MP0001835_abnormal_antigen_presentation2.17687089
12MP0008438_abnormal_cutaneous_collagen2.11664872
13MP0002877_abnormal_melanocyte_morpholog2.06626977
14MP0002419_abnormal_innate_immunity2.02532658
15MP0004947_skin_inflammation1.97823063
16MP0000685_abnormal_immune_system1.92322048
17MP0000858_altered_metastatic_potential1.90985507
18MP0003763_abnormal_thymus_physiology1.90759242
19MP0005000_abnormal_immune_tolerance1.85931461
20MP0005025_abnormal_response_to1.84660281
21MP0009840_abnormal_foam_cell1.79126362
22MP0003091_abnormal_cell_migration1.78027483
23MP0003172_abnormal_lysosome_physiology1.77912224
24MP0009785_altered_susceptibility_to1.73151829
25MP0001790_abnormal_immune_system1.73127602
26MP0005387_immune_system_phenotype1.73127602
27MP0001533_abnormal_skeleton_physiology1.73036139
28MP0005464_abnormal_platelet_physiology1.68606002
29MP0006082_CNS_inflammation1.65616853
30MP0010234_abnormal_vibrissa_follicle1.62615292
31MP0005076_abnormal_cell_differentiation1.62278778
32MP0001800_abnormal_humoral_immune1.59961449
33MP0003453_abnormal_keratinocyte_physiol1.59953585
34MP0009333_abnormal_splenocyte_physiolog1.59758364
35MP0001849_ear_inflammation1.58679912
36MP0002452_abnormal_antigen_presenting1.53544640
37MP0003828_pulmonary_edema1.52327795
38MP0002723_abnormal_immune_serum1.50832348
39MP0002420_abnormal_adaptive_immunity1.49956846
40MP0001819_abnormal_immune_cell1.49174885
41MP0010155_abnormal_intestine_physiology1.48607294
42MP0002998_abnormal_bone_remodeling1.45094550
43MP0002405_respiratory_system_inflammati1.39146088
44MP0009278_abnormal_bone_marrow1.37626557
45MP0010352_gastrointestinal_tract_polyps1.35756686
46MP0002148_abnormal_hypersensitivity_rea1.35146851
47MP0005023_abnormal_wound_healing1.35104507
48MP0005671_abnormal_response_to1.29384140
49MP0002398_abnormal_bone_marrow1.25498866
50MP0004185_abnormal_adipocyte_glucose1.24578359
51MP0003448_altered_tumor_morphology1.22863905
52MP0005409_darkened_coat_color1.20202420
53MP0002396_abnormal_hematopoietic_system1.18824618
54MP0000716_abnormal_immune_system1.17539527
55MP0001958_emphysema1.16924855
56MP0001851_eye_inflammation1.16412072
57MP0003075_altered_response_to1.16152624
58MP0001845_abnormal_inflammatory_respons1.16148156
59MP0000604_amyloidosis1.15777768
60MP0001915_intracranial_hemorrhage1.14008762
61MP0004510_myositis1.13224171
62MP0004264_abnormal_extraembryonic_tissu1.11605793
63MP0005257_abnormal_intraocular_pressure1.11309513
64MP0003279_aneurysm1.11266149
65MP0004858_abnormal_nervous_system1.09762330
66MP0005164_abnormal_response_to1.09751733
67MP0001853_heart_inflammation1.06308354
68MP0002722_abnormal_immune_system1.05886610
69MP0002796_impaired_skin_barrier1.05609943
70MP0000465_gastrointestinal_hemorrhage1.05197162
71MP0002166_altered_tumor_susceptibility1.04895066
72MP0004381_abnormal_hair_follicle1.03841007
73MP0003329_amyloid_beta_deposits1.03299899
74MP0004808_abnormal_hematopoietic_stem1.02916114
75MP0000703_abnormal_thymus_morphology1.02385341
76MP0002429_abnormal_blood_cell1.02258112
77MP0008469_abnormal_protein_level1.02247827
78MP0004272_abnormal_basement_membrane1.01827174
79MP0000767_abnormal_smooth_muscle0.96791728
80MP0004883_abnormal_blood_vessel0.96291639
81MP0002132_abnormal_respiratory_system0.96105305
82MP0003183_abnormal_peptide_metabolism0.94480008
83MP0003866_abnormal_defecation0.94285467
84MP0003656_abnormal_erythrocyte_physiolo0.93396524
85MP0000689_abnormal_spleen_morphology0.93123723
86MP0002060_abnormal_skin_morphology0.91397355
87MP0000343_altered_response_to0.90042773
88MP0002933_joint_inflammation0.87312377
89MP0000490_abnormal_crypts_of0.86590592
90MP0005390_skeleton_phenotype0.86524988
91MP0006054_spinal_hemorrhage0.86286482
92MP0005621_abnormal_cell_physiology0.85106091
93MP0004233_abnormal_muscle_weight0.83389985
94MP0005166_decreased_susceptibility_to0.82822687
95MP0005397_hematopoietic_system_phenotyp0.82509843
96MP0001545_abnormal_hematopoietic_system0.82509843
97MP0005666_abnormal_adipose_tissue0.82437300
98MP0001348_abnormal_lacrimal_gland0.82235076
99MP0003221_abnormal_cardiomyocyte_apopto0.80518598
100MP0003795_abnormal_bone_structure0.79806228

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.06812960
2Abnormality of macrophages (HP:0004311)3.25708367
3Protrusio acetabuli (HP:0003179)3.07913807
4Recurrent abscess formation (HP:0002722)2.98026658
5Recurrent bacterial skin infections (HP:0005406)2.91421077
6Deep venous thrombosis (HP:0002625)2.87780352
7Myositis (HP:0100614)2.78628424
8Premature rupture of membranes (HP:0001788)2.75041100
9Orchitis (HP:0100796)2.73070532
10Vertebral compression fractures (HP:0002953)2.65906186
11Recurrent gram-negative bacterial infections (HP:0005420)2.56643882
12Cellulitis (HP:0100658)2.44383303
13Peritonitis (HP:0002586)2.43844600
14Gastrointestinal infarctions (HP:0005244)2.43464745
15Cerebral aneurysm (HP:0004944)2.36670601
16Spontaneous hematomas (HP:0007420)2.33979719
17Increased IgE level (HP:0003212)2.31512815
18Gingivitis (HP:0000230)2.29199291
19Retrobulbar optic neuritis (HP:0100654)2.28574518
20Optic neuritis (HP:0100653)2.28574518
21Arterial tortuosity (HP:0005116)2.27882854
22Abnormality of glycolipid metabolism (HP:0010969)2.23134198
23Abnormality of liposaccharide metabolism (HP:0010968)2.23134198
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.23134198
25Dilatation of the ascending aorta (HP:0005111)2.22804897
26Flat acetabular roof (HP:0003180)2.21677580
27Hemorrhage of the eye (HP:0011885)2.20640507
28Vascular tortuosity (HP:0004948)2.17613672
29Dysostosis multiplex (HP:0000943)2.16482200
30Myocardial infarction (HP:0001658)2.10221496
31Segmental peripheral demyelination/remyelination (HP:0003481)2.07150523
32Subacute progressive viral hepatitis (HP:0006572)2.06289228
33Thin bony cortex (HP:0002753)2.04867000
34Mediastinal lymphadenopathy (HP:0100721)2.04354453
35Asymmetry of the thorax (HP:0001555)1.99569702
36Obstructive lung disease (HP:0006536)1.99081642
37Chronic obstructive pulmonary disease (HP:0006510)1.99081642
38Loss of speech (HP:0002371)1.98431591
39Amyloidosis (HP:0011034)1.98095028
40Polycythemia (HP:0001901)1.97934335
41Increased connective tissue (HP:0009025)1.97221574
42Gingival bleeding (HP:0000225)1.97088126
43Recurrent viral infections (HP:0004429)1.94901607
44Interstitial pulmonary disease (HP:0006530)1.94636204
45Polygenic inheritance (HP:0010982)1.93814247
46Aneurysm (HP:0002617)1.92450097
47Broad face (HP:0000283)1.92045642
48Abnormality of the peritoneum (HP:0002585)1.92001552
49Systemic lupus erythematosus (HP:0002725)1.91609650
50Recurrent fungal infections (HP:0002841)1.90307778
51Vasculitis (HP:0002633)1.89951799
52Osteolytic defects of the phalanges of the hand (HP:0009771)1.89674781
53Osteolytic defects of the hand bones (HP:0009699)1.89674781
54Meningitis (HP:0001287)1.87705226
55Mucopolysacchariduria (HP:0008155)1.87391140
56Urinary glycosaminoglycan excretion (HP:0003541)1.87391140
57Recurrent skin infections (HP:0001581)1.86455756
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85898197
59Spinal cord lesions (HP:0100561)1.83815114
60Syringomyelia (HP:0003396)1.83815114
61Epistaxis (HP:0000421)1.83742828
62Purpura (HP:0000979)1.83565669
63Urticaria (HP:0001025)1.82238016
64Gastrointestinal inflammation (HP:0004386)1.82227797
65Abnormality of the common coagulation pathway (HP:0010990)1.82171572
66Arterial thrombosis (HP:0004420)1.82144364
67Slow saccadic eye movements (HP:0000514)1.81473936
68Abnormality of oral frenula (HP:0000190)1.81307486
69Cervical subluxation (HP:0003308)1.81148073
70Elevated erythrocyte sedimentation rate (HP:0003565)1.81035727
71Colitis (HP:0002583)1.80740826
72Spondylolisthesis (HP:0003302)1.80566318
73Ankyloglossia (HP:0010296)1.80246991
74Pustule (HP:0200039)1.79557999
75Increased variability in muscle fiber diameter (HP:0003557)1.79257750
76Aortic aneurysm (HP:0004942)1.78418151
77Blue sclerae (HP:0000592)1.77983588
78Aortic dissection (HP:0002647)1.77095332
79Cerebral inclusion bodies (HP:0100314)1.75931166
80Increased cerebral lipofuscin (HP:0011813)1.75079487
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75013863
82Abnormality of polysaccharide metabolism (HP:0011012)1.75013863
83Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75013863
84Hyperacusis (HP:0010780)1.74953146
85Disproportionate tall stature (HP:0001519)1.73766093
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.72252212
87Abnormality of complement system (HP:0005339)1.72155012
88T lymphocytopenia (HP:0005403)1.71899924
89Abnormality of skeletal muscle fiber size (HP:0012084)1.71589286
90Achilles tendon contracture (HP:0001771)1.70487570
91Inflammation of the large intestine (HP:0002037)1.70073846
92Keratoconjunctivitis sicca (HP:0001097)1.69584668
93Abnormal platelet volume (HP:0011876)1.69426309
94Distal lower limb amyotrophy (HP:0008944)1.68456219
95Prolonged bleeding time (HP:0003010)1.68041180
96Abnormality of the Achilles tendon (HP:0005109)1.65342781
97Neurofibrillary tangles (HP:0002185)1.65060744
98Emphysema (HP:0002097)1.64646647
99Osteomyelitis (HP:0002754)1.63510868
100Bone pain (HP:0002653)1.63227102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.66810351
2TRIB33.61002531
3ERN13.05353614
4RIPK42.51985468
5SMG12.47888591
6FGFR42.46867923
7IRAK32.17462406
8MAP4K12.09863067
9MAP2K32.09727282
10TYK22.02847992
11ICK1.98463197
12RIPK11.96353304
13CDK121.96031576
14MAP3K131.94116456
15MAP3K141.86042866
16SIK11.81953233
17MAP3K31.74196176
18EPHB11.71809913
19ZAP701.65014180
20KSR21.58592968
21CSK1.57335758
22IRAK41.54900020
23PDGFRA1.52756892
24EEF2K1.45678434
25TTN1.40332969
26TAOK21.37100252
27JAK31.34710041
28FGFR31.33813145
29PKN21.33517704
30MAP3K11.26365929
31PAK41.23401180
32BLK1.22600901
33TBK11.22107800
34JAK11.21573338
35MAP3K101.18446708
36PTK61.12950106
37SIK31.12570979
38CDC42BPA1.09721927
39GRK61.07063010
40TAOK11.06275238
41FGR1.03588134
42FES0.98096396
43TGFBR20.97525732
44PDPK10.93550555
45CDK60.90242831
46MARK20.89490193
47HCK0.88430947
48BTK0.86359064
49MAP3K110.86114754
50EPHA20.86085051
51MAP3K20.84200432
52LRRK20.83950836
53IKBKE0.81676979
54TESK20.80657181
55RET0.79957889
56LATS20.79197300
57JAK20.78950996
58STK100.77561005
59PRKD20.76976106
60MAP3K60.75666476
61NEK90.74100282
62YES10.73083047
63NME20.71858572
64MAP3K80.71397218
65PDK10.70969149
66ARAF0.70450538
67MOS0.68441077
68SCYL20.66946238
69TESK10.65677239
70CSF1R0.65624701
71IRAK20.64821443
72PDGFRB0.61583224
73CDK40.61185791
74MTOR0.60213115
75MAPK110.60149144
76TYRO30.59889789
77LCK0.58326071
78PTK20.56383428
79STK380.56057525
80RPS6KA20.55052315
81HIPK20.54659879
82BMX0.54177196
83SIK20.53090676
84SGK30.51344599
85SYK0.51115222
86RPS6KL10.50997451
87RPS6KC10.50997451
88ITK0.47489052
89DDR20.46789348
90MAP3K70.46526640
91MAP3K90.46081318
92MST1R0.45384712
93LYN0.45167202
94MATK0.44262846
95PRKG20.43879246
96CLK10.42926191
97MELK0.42278155
98MARK30.42257706
99MAPK120.41707006
100KSR10.40672538

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64718358
2Other glycan degradation_Homo sapiens_hsa005112.24378644
3Osteoclast differentiation_Homo sapiens_hsa043802.12300722
4Acute myeloid leukemia_Homo sapiens_hsa052212.00623636
5B cell receptor signaling pathway_Homo sapiens_hsa046621.93726469
6Leishmaniasis_Homo sapiens_hsa051401.89551156
7Chronic myeloid leukemia_Homo sapiens_hsa052201.85547208
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69924857
9Non-small cell lung cancer_Homo sapiens_hsa052231.68673378
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68014584
11Pancreatic cancer_Homo sapiens_hsa052121.60996137
12Staphylococcus aureus infection_Homo sapiens_hsa051501.53436278
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53373618
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49820166
15Measles_Homo sapiens_hsa051621.44862530
16Toxoplasmosis_Homo sapiens_hsa051451.42662037
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.40860525
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40693069
19T cell receptor signaling pathway_Homo sapiens_hsa046601.40495494
20Malaria_Homo sapiens_hsa051441.39791099
21VEGF signaling pathway_Homo sapiens_hsa043701.38079771
22TNF signaling pathway_Homo sapiens_hsa046681.35799516
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.35471623
24Influenza A_Homo sapiens_hsa051641.34878822
25Tuberculosis_Homo sapiens_hsa051521.34101772
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34055805
27Hepatitis B_Homo sapiens_hsa051611.33751225
28Renal cell carcinoma_Homo sapiens_hsa052111.31176745
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.30169121
30Hepatitis C_Homo sapiens_hsa051601.27079114
31Endometrial cancer_Homo sapiens_hsa052131.25874233
32Bladder cancer_Homo sapiens_hsa052191.24027341
33Thyroid cancer_Homo sapiens_hsa052161.23446793
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22267391
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21208834
36Amoebiasis_Homo sapiens_hsa051461.17946657
37Prion diseases_Homo sapiens_hsa050201.16728685
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.14731155
39Shigellosis_Homo sapiens_hsa051311.14680943
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.14295123
41Apoptosis_Homo sapiens_hsa042101.12309684
42Chemokine signaling pathway_Homo sapiens_hsa040621.07445397
43Prolactin signaling pathway_Homo sapiens_hsa049171.06754294
44Small cell lung cancer_Homo sapiens_hsa052221.05875790
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05525762
46Lysosome_Homo sapiens_hsa041421.05019200
47Pertussis_Homo sapiens_hsa051331.03475870
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.01526398
49Legionellosis_Homo sapiens_hsa051341.01514253
50Notch signaling pathway_Homo sapiens_hsa043301.00431438
51Herpes simplex infection_Homo sapiens_hsa051681.00058685
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99352912
53Viral myocarditis_Homo sapiens_hsa054160.98348654
54Proteoglycans in cancer_Homo sapiens_hsa052050.98098966
55Salmonella infection_Homo sapiens_hsa051320.97327467
56Focal adhesion_Homo sapiens_hsa045100.95649144
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92873045
58Hematopoietic cell lineage_Homo sapiens_hsa046400.91465357
59Prostate cancer_Homo sapiens_hsa052150.91361116
60mTOR signaling pathway_Homo sapiens_hsa041500.90846340
61Complement and coagulation cascades_Homo sapiens_hsa046100.90833290
62Phagosome_Homo sapiens_hsa041450.89006593
63Allograft rejection_Homo sapiens_hsa053300.88545786
64Glioma_Homo sapiens_hsa052140.86407797
65Endocytosis_Homo sapiens_hsa041440.85140264
66HIF-1 signaling pathway_Homo sapiens_hsa040660.84588771
67ErbB signaling pathway_Homo sapiens_hsa040120.83270833
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.83048121
69Pentose phosphate pathway_Homo sapiens_hsa000300.82595581
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.82324040
71Graft-versus-host disease_Homo sapiens_hsa053320.82254312
72Platelet activation_Homo sapiens_hsa046110.81904041
73Autoimmune thyroid disease_Homo sapiens_hsa053200.81839888
74Insulin signaling pathway_Homo sapiens_hsa049100.80041427
75Antigen processing and presentation_Homo sapiens_hsa046120.79393475
76Viral carcinogenesis_Homo sapiens_hsa052030.78092358
77Insulin resistance_Homo sapiens_hsa049310.77906116
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.77366293
79Colorectal cancer_Homo sapiens_hsa052100.77322976
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76580298
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75265742
82African trypanosomiasis_Homo sapiens_hsa051430.73993159
83GnRH signaling pathway_Homo sapiens_hsa049120.73482382
84HTLV-I infection_Homo sapiens_hsa051660.73332843
85Choline metabolism in cancer_Homo sapiens_hsa052310.73178177
86Adherens junction_Homo sapiens_hsa045200.73010038
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71085930
88Inositol phosphate metabolism_Homo sapiens_hsa005620.69997994
89Primary immunodeficiency_Homo sapiens_hsa053400.69781072
90Galactose metabolism_Homo sapiens_hsa000520.69420025
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68583171
92Fructose and mannose metabolism_Homo sapiens_hsa000510.68320648
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65466907
94FoxO signaling pathway_Homo sapiens_hsa040680.65197905
95MicroRNAs in cancer_Homo sapiens_hsa052060.63667715
96Estrogen signaling pathway_Homo sapiens_hsa049150.63452634
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61658721
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54686684
99Epstein-Barr virus infection_Homo sapiens_hsa051690.52115284
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51520884

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