ISY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.43239410
2ribosomal small subunit assembly (GO:0000028)5.02911295
3maturation of SSU-rRNA (GO:0030490)4.46069439
4viral transcription (GO:0019083)4.26181061
5telomere maintenance via semi-conservative replication (GO:0032201)4.25980728
6DNA strand elongation involved in DNA replication (GO:0006271)4.20301939
7translational termination (GO:0006415)4.14276004
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09943326
9DNA strand elongation (GO:0022616)4.03375546
10DNA replication initiation (GO:0006270)3.91764749
11ribosomal small subunit biogenesis (GO:0042274)3.87375994
12energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86082284
13ATP synthesis coupled proton transport (GO:0015986)3.86082284
14telomere maintenance via recombination (GO:0000722)3.81162986
15DNA deamination (GO:0045006)3.78666632
16ribosomal large subunit biogenesis (GO:0042273)3.78380603
17DNA unwinding involved in DNA replication (GO:0006268)3.78327125
18chaperone-mediated protein transport (GO:0072321)3.77709071
19cullin deneddylation (GO:0010388)3.75235009
20translational elongation (GO:0006414)3.72215343
21protein deneddylation (GO:0000338)3.69589437
22formation of translation preinitiation complex (GO:0001731)3.61358480
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53827911
24mitotic recombination (GO:0006312)3.53634703
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52016773
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50080234
27translational initiation (GO:0006413)3.48551383
28ribonucleoprotein complex biogenesis (GO:0022613)3.46067077
29telomere maintenance via telomere lengthening (GO:0010833)3.42253666
30cotranslational protein targeting to membrane (GO:0006613)3.40329736
31protein targeting to ER (GO:0045047)3.39232525
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.34106491
33DNA replication checkpoint (GO:0000076)3.29497383
34nucleobase biosynthetic process (GO:0046112)3.26665552
35ribosome biogenesis (GO:0042254)3.25685076
36viral life cycle (GO:0019058)3.25564364
37CENP-A containing nucleosome assembly (GO:0034080)3.25553424
38cellular protein complex disassembly (GO:0043624)3.22367845
39kinetochore organization (GO:0051383)3.21743703
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21643828
41regulation of B cell receptor signaling pathway (GO:0050855)3.20168076
42folic acid-containing compound biosynthetic process (GO:0009396)3.19866106
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.19587660
44NADH dehydrogenase complex assembly (GO:0010257)3.19587660
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19587660
46chromatin remodeling at centromere (GO:0031055)3.18149636
47protein localization to endoplasmic reticulum (GO:0070972)3.15838040
48mitotic nuclear envelope disassembly (GO:0007077)3.15699153
49protein complex biogenesis (GO:0070271)3.13543284
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13313575
51IMP biosynthetic process (GO:0006188)3.10426002
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09735162
53rRNA processing (GO:0006364)3.08476080
54protein localization to kinetochore (GO:0034501)3.07657397
55mitochondrial respiratory chain complex assembly (GO:0033108)3.06824969
56mitotic metaphase plate congression (GO:0007080)3.06762309
57metaphase plate congression (GO:0051310)3.03588637
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01946757
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01891873
60platelet dense granule organization (GO:0060155)2.99434912
61DNA replication-independent nucleosome assembly (GO:0006336)2.98660343
62DNA replication-independent nucleosome organization (GO:0034724)2.98660343
63rRNA metabolic process (GO:0016072)2.98521246
64purine nucleobase biosynthetic process (GO:0009113)2.96034235
65nuclear-transcribed mRNA catabolic process (GO:0000956)2.93865016
66kinetochore assembly (GO:0051382)2.93053968
67replication fork processing (GO:0031297)2.92373248
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92236843
69nuclear pore organization (GO:0006999)2.91891109
70protein complex disassembly (GO:0043241)2.91002368
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90932901
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90932901
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90932901
74nuclear envelope disassembly (GO:0051081)2.88113046
75membrane disassembly (GO:0030397)2.88113046
76meiotic chromosome segregation (GO:0045132)2.88107392
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84144014
78protein-cofactor linkage (GO:0018065)2.84081995
79telomere maintenance (GO:0000723)2.83581022
80ribosome assembly (GO:0042255)2.83284491
81mRNA catabolic process (GO:0006402)2.83024397
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82358664
83telomere organization (GO:0032200)2.82115028
84interferon-gamma production (GO:0032609)2.82103574
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81913590
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81913590
87pseudouridine synthesis (GO:0001522)2.78819878
88response to interferon-beta (GO:0035456)2.78230589
89RNA catabolic process (GO:0006401)2.78098053
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78092236
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.78092236
92adenosine metabolic process (GO:0046085)2.77954727
93nuclear pore complex assembly (GO:0051292)2.77651865
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77598456
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.77598456
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.77536284
97establishment of chromosome localization (GO:0051303)2.77490753
98inner mitochondrial membrane organization (GO:0007007)2.76802125
99macromolecular complex disassembly (GO:0032984)2.75805736
100regulation of cellular amino acid metabolic process (GO:0006521)2.74949276
101DNA replication-dependent nucleosome organization (GO:0034723)2.74044760
102DNA replication-dependent nucleosome assembly (GO:0006335)2.74044760
103protein localization to chromosome, centromeric region (GO:0071459)2.73053511
104respiratory chain complex IV assembly (GO:0008535)2.72617760
105electron transport chain (GO:0022900)2.72584866
106respiratory electron transport chain (GO:0022904)2.72407749
107IMP metabolic process (GO:0046040)2.71869861
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71376552
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71376552
110transcription-coupled nucleotide-excision repair (GO:0006283)2.70812635
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.70717207
112cytochrome complex assembly (GO:0017004)2.68352294
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68232193
114negative regulation of ligase activity (GO:0051352)2.68232193
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68140663
116protein neddylation (GO:0045116)2.67558615
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67384930
118negative regulation of RNA splicing (GO:0033119)2.67097137
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66953279
120regulation of mitotic spindle checkpoint (GO:1903504)2.66953279
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66468127
122proteasome assembly (GO:0043248)2.66120046
123translation (GO:0006412)2.65391303
124DNA duplex unwinding (GO:0032508)2.63298600
125rRNA modification (GO:0000154)2.62976439
126viral mRNA export from host cell nucleus (GO:0046784)2.62584612
127DNA geometric change (GO:0032392)2.61842326
128protein targeting to mitochondrion (GO:0006626)2.61662347
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61540753
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61415759
131positive regulation of gamma-delta T cell activation (GO:0046645)2.61371781
132cellular response to interferon-beta (GO:0035458)2.59679171
133mast cell activation (GO:0045576)2.59436833
134antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.59104355
135spliceosomal snRNP assembly (GO:0000387)2.57725001
136termination of RNA polymerase III transcription (GO:0006386)2.56956162
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.56956162
138preassembly of GPI anchor in ER membrane (GO:0016254)2.55153358
139mismatch repair (GO:0006298)2.55053000
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54638151
141mannosylation (GO:0097502)2.54308098
142mitotic sister chromatid segregation (GO:0000070)2.53261435
143regulation of spindle organization (GO:0090224)2.52704259
144protein localization to mitochondrion (GO:0070585)2.51926058
145establishment of protein localization to mitochondrion (GO:0072655)2.51725721
146spliceosomal complex assembly (GO:0000245)2.51681501
147translesion synthesis (GO:0019985)2.51043864
148attachment of spindle microtubules to kinetochore (GO:0008608)2.50803674
149* RNA splicing, via transesterification reactions (GO:0000375)2.50349414
150protein K6-linked ubiquitination (GO:0085020)2.50141497
151histone exchange (GO:0043486)2.49414922
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48600965
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48600965
154isotype switching (GO:0045190)2.48600965
155* mRNA splicing, via spliceosome (GO:0000398)2.48555917
156* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.48555917
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.48313487
158sequestering of actin monomers (GO:0042989)2.48030898
159G1/S transition of mitotic cell cycle (GO:0000082)2.47408287
160cell cycle G1/S phase transition (GO:0044843)2.47408287
161cellular component biogenesis (GO:0044085)2.46959309
162cytidine metabolic process (GO:0046087)2.46279267
163cytidine catabolic process (GO:0006216)2.46279267
164cytidine deamination (GO:0009972)2.46279267
165intracellular protein transmembrane import (GO:0044743)2.45985962
166ubiquinone biosynthetic process (GO:0006744)2.45820700
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.44447583
168maturation of 5.8S rRNA (GO:0000460)2.40992343
169tRNA processing (GO:0008033)2.40961036
170DNA catabolic process, exonucleolytic (GO:0000738)2.40782631
171DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.40260778
172positive regulation of ligase activity (GO:0051351)2.39085592
173purine-containing compound salvage (GO:0043101)2.38525890
174RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37751464
175deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.37366507
176mast cell activation involved in immune response (GO:0002279)2.36711296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53322108
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.93049598
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48328294
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.45668256
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44432333
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85917182
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.73983772
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67979019
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63751507
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.63473932
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.58810952
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52637166
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50661042
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50494329
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42154393
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.41946192
17* VDR_23849224_ChIP-Seq_CD4+_Human2.32890433
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30848263
19MYC_22102868_ChIP-Seq_BL_Human2.26725281
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18064651
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17892115
22* XRN2_22483619_ChIP-Seq_HELA_Human2.08860508
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06609302
24FOXP3_21729870_ChIP-Seq_TREG_Human2.05342397
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03680216
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.02604959
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99321746
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.91931838
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91582348
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91536972
31DCP1A_22483619_ChIP-Seq_HELA_Human1.89010502
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87566647
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81929383
34CIITA_25753668_ChIP-Seq_RAJI_Human1.80481635
35ZNF274_21170338_ChIP-Seq_K562_Hela1.80003318
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76847994
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76092433
38TTF2_22483619_ChIP-Seq_HELA_Human1.74818166
39ELK1_19687146_ChIP-ChIP_HELA_Human1.71583396
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71433733
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69887152
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68779946
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67837615
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66893397
45IRF1_19129219_ChIP-ChIP_H3396_Human1.66858637
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65527476
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65316520
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.65314206
49* GABP_19822575_ChIP-Seq_HepG2_Human1.65203119
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64249957
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62001025
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58247438
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57089419
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55884917
55* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53243628
56VDR_22108803_ChIP-Seq_LS180_Human1.53075979
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52268651
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51501628
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49358792
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.48475561
61SPI1_23547873_ChIP-Seq_NB4_Human1.47126263
62AR_21909140_ChIP-Seq_LNCAP_Human1.46570674
63* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46539021
64VDR_21846776_ChIP-Seq_THP-1_Human1.45663065
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45098067
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42940723
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42362027
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41100184
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40875599
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37684144
71SCL_19346495_ChIP-Seq_HPC-7_Human1.36998504
72MYB_26560356_Chip-Seq_TH2_Human1.36086666
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.33440070
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.33010642
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.32463326
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30014443
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29390741
78KDM5A_27292631_Chip-Seq_BREAST_Human1.27566551
79* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26985547
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26537426
81MYB_26560356_Chip-Seq_TH1_Human1.26157539
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24333054
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23491811
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22150244
85TP53_22573176_ChIP-Seq_HFKS_Human1.20650596
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20254500
87* MAF_26560356_Chip-Seq_TH1_Human1.19564569
88GATA3_26560356_Chip-Seq_TH2_Human1.19057038
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18504453
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18213739
91EWS_26573619_Chip-Seq_HEK293_Human1.16955085
92TFEB_21752829_ChIP-Seq_HELA_Human1.16057943
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15000340
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14829954
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.10387345
96* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07898288
97UTX_26944678_Chip-Seq_JUKART_Human1.07522347
98* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02657779
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02217061
100MYC_18940864_ChIP-ChIP_HL60_Human1.02005228
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01773183
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00839787
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00344549
104* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99263178
105* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96550112
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93654344
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93465233
108* MAF_26560356_Chip-Seq_TH2_Human0.91697682
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90771954
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90740429
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90261739
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89317231
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.89317231
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88329697
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88299451
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86790010
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86580573
118AR_20517297_ChIP-Seq_VCAP_Human0.85585843
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85201470
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85107933
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84995767
122GATA3_27048872_Chip-Seq_THYMUS_Human0.84988982
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84986064
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84609738
125* ELK1_22589737_ChIP-Seq_MCF10A_Human0.84225579
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84214661
127RUNX_20019798_ChIP-Seq_JUKART_Human0.83670070
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.81892138
129IGF1R_20145208_ChIP-Seq_DFB_Human0.80096198
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78410084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.18480306
2MP0010094_abnormal_chromosome_stability3.73737479
3MP0002396_abnormal_hematopoietic_system3.32006690
4MP0008057_abnormal_DNA_replication3.30455110
5MP0003111_abnormal_nucleus_morphology3.25845257
6MP0003077_abnormal_cell_cycle3.17682733
7MP0004957_abnormal_blastocyst_morpholog3.12552626
8MP0008058_abnormal_DNA_repair3.02555540
9MP0003763_abnormal_thymus_physiology2.90080004
10MP0003806_abnormal_nucleotide_metabolis2.56375023
11MP0001835_abnormal_antigen_presentation2.56338011
12MP0008007_abnormal_cellular_replicative2.54680940
13MP0008995_early_reproductive_senescence2.53786905
14MP0005671_abnormal_response_to2.42748063
15MP0000685_abnormal_immune_system2.33351038
16MP0000490_abnormal_crypts_of2.18867322
17MP0001800_abnormal_humoral_immune2.13757498
18MP0002398_abnormal_bone_marrow2.13239982
19MP0004808_abnormal_hematopoietic_stem2.00818665
20MP0000569_abnormal_digit_pigmentation1.96914494
21MP0009333_abnormal_splenocyte_physiolog1.94952034
22MP0000703_abnormal_thymus_morphology1.92871659
23MP0009764_decreased_sensitivity_to1.88294476
24MP0006072_abnormal_retinal_apoptosis1.86458519
25MP0009785_altered_susceptibility_to1.81422500
26MP0002722_abnormal_immune_system1.81273587
27MP0002420_abnormal_adaptive_immunity1.80187344
28MP0002452_abnormal_antigen_presenting1.79704492
29MP0005387_immune_system_phenotype1.79265225
30MP0001790_abnormal_immune_system1.79265225
31MP0002723_abnormal_immune_serum1.79249137
32MP0001819_abnormal_immune_cell1.78824494
33MP0008932_abnormal_embryonic_tissue1.76990690
34MP0000689_abnormal_spleen_morphology1.75601248
35MP0010352_gastrointestinal_tract_polyps1.74885812
36MP0005000_abnormal_immune_tolerance1.74836648
37MP0000716_abnormal_immune_system1.72758104
38MP0002405_respiratory_system_inflammati1.67129217
39MP0001853_heart_inflammation1.66828800
40MP0000350_abnormal_cell_proliferation1.63320573
41MP0001873_stomach_inflammation1.62532137
42MP0002429_abnormal_blood_cell1.60951622
43MP0005397_hematopoietic_system_phenotyp1.60848633
44MP0001545_abnormal_hematopoietic_system1.60848633
45MP0003436_decreased_susceptibility_to1.58521053
46MP0003786_premature_aging1.57638099
47MP0002019_abnormal_tumor_incidence1.55639840
48MP0006036_abnormal_mitochondrial_physio1.55330694
49MP0005025_abnormal_response_to1.54409339
50MP0000372_irregular_coat_pigmentation1.53948183
51MP0002653_abnormal_ependyma_morphology1.53192249
52MP0005084_abnormal_gallbladder_morpholo1.53183790
53MP0003724_increased_susceptibility_to1.50534992
54MP0010307_abnormal_tumor_latency1.48701939
55MP0003646_muscle_fatigue1.47524520
56MP0008877_abnormal_DNA_methylation1.45675243
57MP0010155_abnormal_intestine_physiology1.45254753
58MP0000858_altered_metastatic_potential1.41032114
59MP0003186_abnormal_redox_activity1.38999909
60MP0002148_abnormal_hypersensitivity_rea1.37621712
61MP0004147_increased_porphyrin_level1.36550632
62MP0002132_abnormal_respiratory_system1.36212493
63MP0001730_embryonic_growth_arrest1.34107028
64MP0002166_altered_tumor_susceptibility1.33479266
65MP0000313_abnormal_cell_death1.32443316
66MP0002006_tumorigenesis1.30912826
67MP0008875_abnormal_xenobiotic_pharmacok1.30627268
68MP0006292_abnormal_olfactory_placode1.29464742
69MP0002102_abnormal_ear_morphology1.28203342
70MP0009379_abnormal_foot_pigmentation1.20063470
71MP0002419_abnormal_innate_immunity1.17943934
72MP0001986_abnormal_taste_sensitivity1.16056880
73MP0003123_paternal_imprinting1.14631125
74MP0000465_gastrointestinal_hemorrhage1.12395144
75MP0008872_abnormal_physiological_respon1.10285639
76MP0004142_abnormal_muscle_tone1.09842071
77MP0003866_abnormal_defecation1.06117199
78MP0001845_abnormal_inflammatory_respons1.05976133
79MP0005076_abnormal_cell_differentiation1.04226154
80MP0005380_embryogenesis_phenotype1.03506613
81MP0001672_abnormal_embryogenesis/_devel1.03506613
82MP0006035_abnormal_mitochondrial_morpho1.00505853
83MP0003984_embryonic_growth_retardation0.99958252
84MP0003718_maternal_effect0.98200451
85MP0001697_abnormal_embryo_size0.98187219
86MP0002088_abnormal_embryonic_growth/wei0.98069547
87MP0005464_abnormal_platelet_physiology0.97838930
88MP0002080_prenatal_lethality0.97336298
89MP0005075_abnormal_melanosome_morpholog0.97242681
90MP0005174_abnormal_tail_pigmentation0.97051453
91MP0002277_abnormal_respiratory_mucosa0.95855538
92MP0003448_altered_tumor_morphology0.95599833
93MP0005645_abnormal_hypothalamus_physiol0.93802830
94MP0006082_CNS_inflammation0.93297611
95MP0004947_skin_inflammation0.92816034
96MP0005253_abnormal_eye_physiology0.92535551
97MP0002928_abnormal_bile_duct0.92350359
98MP0002933_joint_inflammation0.91903755
99MP0002086_abnormal_extraembryonic_tissu0.90640656
100MP0003136_yellow_coat_color0.89795073
101MP0009278_abnormal_bone_marrow0.89214900
102MP0003567_abnormal_fetal_cardiomyocyte0.86940477
103MP0001919_abnormal_reproductive_system0.86921486
104MP0006054_spinal_hemorrhage0.85026221
105MP0003195_calcinosis0.84949612
106MP0003011_delayed_dark_adaptation0.84424870
107MP0003941_abnormal_skin_development0.83943955
108MP0005389_reproductive_system_phenotype0.83346154
109MP0002095_abnormal_skin_pigmentation0.82610250
110MP0003303_peritoneal_inflammation0.80003909
111MP0001929_abnormal_gametogenesis0.79486581
112MP0009765_abnormal_xenobiotic_induced0.78924835
113MP0001764_abnormal_homeostasis0.77693619
114MP0000015_abnormal_ear_pigmentation0.77643933
115MP0000358_abnormal_cell_content/0.77058394
116MP0005410_abnormal_fertilization0.76667906
117MP0004197_abnormal_fetal_growth/weight/0.76640743
118MP0002938_white_spotting0.76263234
119MP0004510_myositis0.76231001
120MP0005551_abnormal_eye_electrophysiolog0.75693146
121MP0001905_abnormal_dopamine_level0.71239424
122MP0002085_abnormal_embryonic_tissue0.71106222
123MP0002163_abnormal_gland_morphology0.70418817
124MP0001119_abnormal_female_reproductive0.69478514
125MP0009763_increased_sensitivity_to0.69087473
126MP0002876_abnormal_thyroid_physiology0.68532336
127MP0001293_anophthalmia0.66731424
128MP0003638_abnormal_response/metabolism_0.66516020
129MP0000477_abnormal_intestine_morphology0.64958091
130MP0008469_abnormal_protein_level0.63367513
131MP0001533_abnormal_skeleton_physiology0.62540368
132MP0002084_abnormal_developmental_patter0.62049322
133MP0002210_abnormal_sex_determination0.62036170
134MP0003943_abnormal_hepatobiliary_system0.61484259
135MP0005023_abnormal_wound_healing0.59377616
136MP0005621_abnormal_cell_physiology0.59125243
137MP0003121_genomic_imprinting0.58822918
138MP0005310_abnormal_salivary_gland0.58372953
139MP0003300_gastrointestinal_ulcer0.55294752
140MP0002075_abnormal_coat/hair_pigmentati0.55154924

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.51261712
2Birth length less than 3rd percentile (HP:0003561)4.22025653
3Abnormality of cells of the erythroid lineage (HP:0012130)4.13131745
4Abnormal number of erythroid precursors (HP:0012131)4.04499530
5Chromsome breakage (HP:0040012)3.74009972
6Mitochondrial inheritance (HP:0001427)3.69623412
7Acute necrotizing encephalopathy (HP:0006965)3.68904182
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63027764
9IgM deficiency (HP:0002850)3.58617304
10Increased CSF lactate (HP:0002490)3.54289710
11Thrombocytosis (HP:0001894)3.39226488
12Abnormal mitochondria in muscle tissue (HP:0008316)3.32885470
13Myositis (HP:0100614)3.32724292
14Increased hepatocellular lipid droplets (HP:0006565)3.28750521
15Pallor (HP:0000980)3.25481555
16Hepatocellular necrosis (HP:0001404)3.17914360
17Acute encephalopathy (HP:0006846)3.16037050
183-Methylglutaconic aciduria (HP:0003535)3.04324112
19Progressive macrocephaly (HP:0004481)3.03209613
20Lipid accumulation in hepatocytes (HP:0006561)3.00988630
21Colon cancer (HP:0003003)3.00171434
22Retrobulbar optic neuritis (HP:0100654)2.96816253
23Optic neuritis (HP:0100653)2.96816253
24Aplastic anemia (HP:0001915)2.92278798
25Elevated erythrocyte sedimentation rate (HP:0003565)2.92144991
26Hepatic necrosis (HP:0002605)2.88528243
27Pancreatic cysts (HP:0001737)2.83612522
28Increased serum lactate (HP:0002151)2.81542201
29Oral leukoplakia (HP:0002745)2.81103905
30Myelodysplasia (HP:0002863)2.80156230
31Abnormality of T cells (HP:0002843)2.79900885
32Abnormality of DNA repair (HP:0003254)2.78600443
33Exertional dyspnea (HP:0002875)2.77979746
34Abnormality of the preputium (HP:0100587)2.77975640
35IgG deficiency (HP:0004315)2.76938821
36Lymphoma (HP:0002665)2.76585496
37Poikiloderma (HP:0001029)2.76394084
38Macrocytic anemia (HP:0001972)2.69972657
39Orchitis (HP:0100796)2.69247177
40T lymphocytopenia (HP:0005403)2.68060336
41Stomatitis (HP:0010280)2.67868404
42Abnormality of chromosome stability (HP:0003220)2.67292561
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65410179
44Abnormality of T cell physiology (HP:0011840)2.60751373
45Renal Fanconi syndrome (HP:0001994)2.57182533
46Optic disc pallor (HP:0000543)2.56442584
47Abnormality of T cell number (HP:0011839)2.55464248
48Agnosia (HP:0010524)2.54832513
49Autoimmune thrombocytopenia (HP:0001973)2.53714229
50Constricted visual fields (HP:0001133)2.53020073
51Meckel diverticulum (HP:0002245)2.52784747
52Panhypogammaglobulinemia (HP:0003139)2.52441587
53Severe combined immunodeficiency (HP:0004430)2.49495789
54Recurrent fungal infections (HP:0002841)2.47781402
55Breast hypoplasia (HP:0003187)2.46325697
56Lactic acidosis (HP:0003128)2.45778508
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44901534
58Pancytopenia (HP:0001876)2.44471955
59Combined immunodeficiency (HP:0005387)2.43896420
60Abnormality of the ileum (HP:0001549)2.42392209
61Autoimmune hemolytic anemia (HP:0001890)2.40834322
62Absent thumb (HP:0009777)2.40532703
63Recurrent viral infections (HP:0004429)2.40389911
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.39846483
65Amaurosis fugax (HP:0100576)2.39769050
66Agammaglobulinemia (HP:0004432)2.38808461
67Abnormality of B cell number (HP:0010975)2.37892876
68B lymphocytopenia (HP:0010976)2.37892876
69Cerebral edema (HP:0002181)2.37185261
70Congenital, generalized hypertrichosis (HP:0004540)2.36625484
71Type I transferrin isoform profile (HP:0003642)2.36589287
72Selective tooth agenesis (HP:0001592)2.36331491
73Molar tooth sign on MRI (HP:0002419)2.36092711
74Abnormality of midbrain morphology (HP:0002418)2.36092711
75Congenital stationary night blindness (HP:0007642)2.35898106
76Premature graying of hair (HP:0002216)2.35728678
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35191742
78Abnormal protein N-linked glycosylation (HP:0012347)2.35191742
79Abnormal protein glycosylation (HP:0012346)2.35191742
80Abnormal glycosylation (HP:0012345)2.35191742
81Recurrent bronchitis (HP:0002837)2.33588943
82True hermaphroditism (HP:0010459)2.32427030
83Muscle fiber atrophy (HP:0100295)2.32187479
84Entropion (HP:0000621)2.32102699
85Increased intramyocellular lipid droplets (HP:0012240)2.31624310
86Bone marrow hypocellularity (HP:0005528)2.31075937
87Patellar aplasia (HP:0006443)2.27166003
88Stomach cancer (HP:0012126)2.25128835
89Eosinophilia (HP:0001880)2.22330591
90Duplicated collecting system (HP:0000081)2.20662105
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.20433467
92Meningitis (HP:0001287)2.20204527
93Basal cell carcinoma (HP:0002671)2.19655262
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.19296302
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17341641
96Abnormality of alanine metabolism (HP:0010916)2.17341641
97Hyperalaninemia (HP:0003348)2.17341641
98Neutropenia (HP:0001875)2.16750134
99Medulloblastoma (HP:0002885)2.16692894
100Lymphopenia (HP:0001888)2.16192470
101Increased density of long bones (HP:0006392)2.14858113
102Abnormality of the renal collecting system (HP:0004742)2.14528042
103Abnormality of eosinophils (HP:0001879)2.14139573
104Abnormality of the prostate (HP:0008775)2.14066925
105Pancreatic fibrosis (HP:0100732)2.13942743
106Abnormality of the pons (HP:0007361)2.12766641
107Attenuation of retinal blood vessels (HP:0007843)2.12119484
108Increased IgM level (HP:0003496)2.11545602
109Encephalitis (HP:0002383)2.11296456
110Acute myeloid leukemia (HP:0004808)2.10521881
111Eczematoid dermatitis (HP:0000976)2.10332378
11211 pairs of ribs (HP:0000878)2.09161472
113Aplasia/Hypoplasia of the patella (HP:0006498)2.08349080
114Petechiae (HP:0000967)2.06753726
115Hypoplasia of the pons (HP:0012110)2.06746763
116Cellular immunodeficiency (HP:0005374)2.06270603
117Rough bone trabeculation (HP:0100670)2.05759751
118IgA deficiency (HP:0002720)2.05749736
119Methylmalonic aciduria (HP:0012120)2.05430672
120Keratoconjunctivitis sicca (HP:0001097)2.03825568
121Recurrent abscess formation (HP:0002722)2.03345253
122Pulmonary fibrosis (HP:0002206)2.02871189
123Clubbing of toes (HP:0100760)2.02379993
124Respiratory failure (HP:0002878)2.01364588
125Granulocytopenia (HP:0001913)2.01067050
126Squamous cell carcinoma (HP:0002860)2.00501382
127Ectopic kidney (HP:0000086)2.00367373
128Progressive microcephaly (HP:0000253)1.99647972
129Abnormality of the fingertips (HP:0001211)1.98986804
130Type 2 muscle fiber atrophy (HP:0003554)1.98070804
131Abnormal rod and cone electroretinograms (HP:0008323)1.97681509
132Abnormality of the anterior horn cell (HP:0006802)1.97596626
133Degeneration of anterior horn cells (HP:0002398)1.97596626
134Respiratory difficulties (HP:0002880)1.96840057
135Recurrent cutaneous fungal infections (HP:0011370)1.96809548
136Chronic mucocutaneous candidiasis (HP:0002728)1.96809548
137Abnormal number of incisors (HP:0011064)1.96548861
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96214121
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95877567
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95877567
141Small intestinal stenosis (HP:0012848)1.94795967
142Duodenal stenosis (HP:0100867)1.94795967
143Increased serum pyruvate (HP:0003542)1.94452126
144Mediastinal lymphadenopathy (HP:0100721)1.93110995
145Chronic obstructive pulmonary disease (HP:0006510)1.90669233
146Obstructive lung disease (HP:0006536)1.90669233
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90234649
148Microvesicular hepatic steatosis (HP:0001414)1.89318070
149Neoplasm of the pancreas (HP:0002894)1.89300695
150Cleft eyelid (HP:0000625)1.89132975
151Acute lymphatic leukemia (HP:0006721)1.89059789
152Leukopenia (HP:0001882)1.89041652
153Chronic otitis media (HP:0000389)1.87074710
154Renal cortical cysts (HP:0000803)1.86993230
155Leukocytosis (HP:0001974)1.85947977
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85795598
157Microretrognathia (HP:0000308)1.84967165
158Tracheoesophageal fistula (HP:0002575)1.84368724
159Pulmonary infiltrates (HP:0002113)1.84208473
160Vasculitis (HP:0002633)1.83837095
161Keratoconjunctivitis (HP:0001096)1.83500899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.38399705
2TXK3.35506939
3CDC73.11992461
4MAP4K13.05738299
5BUB12.99617448
6NME22.76068530
7EIF2AK12.74101916
8WEE12.54825955
9TSSK62.17642020
10BCKDK2.02840192
11VRK11.97563759
12NEK21.92446752
13SRPK11.86810134
14RPS6KA41.83764376
15BMPR1B1.72912486
16TEC1.72541470
17STK101.72456668
18ZAP701.72333941
19ACVR1B1.69388293
20PASK1.63089347
21EIF2AK31.62834509
22STK161.61840804
23ADRBK21.61700676
24MAP2K31.60888275
25TLK11.59526845
26ATR1.54574797
27PLK41.51854967
28RPS6KB21.51665866
29JAK31.50519373
30CDK71.49563951
31TAF11.47375540
32BTK1.46205890
33PIM21.45100219
34EEF2K1.41959222
35PIM11.41673006
36KIT1.38432177
37TGFBR11.37932212
38CDK121.37594487
39MAP4K21.37500520
40IKBKB1.34865270
41TTK1.33830636
42PLK11.32344293
43CDK41.28630304
44AURKB1.26690399
45MAP3K141.25789833
46CDK81.24444625
47MKNK11.23113123
48IRAK31.20782694
49PNCK1.19998307
50GRK11.19396603
51BRSK21.15813500
52NME11.15728507
53MAP3K91.13217893
54ITK1.10450113
55TYK21.10064275
56FLT31.10015833
57FRK1.09531765
58MUSK1.08937528
59ZAK1.08685492
60IRAK41.06604321
61EIF2AK21.06155327
62TAOK31.04401455
63MAP3K81.01510559
64BRD40.98836035
65MATK0.97560606
66MKNK20.95322921
67CHUK0.95030593
68GRK60.94289105
69SYK0.93998447
70STK240.93558237
71NLK0.92424576
72DYRK30.92179034
73WNK30.92046705
74STK40.91596714
75FES0.91071082
76TAOK20.89100101
77KDR0.86994171
78CHEK10.85721873
79IKBKE0.84788162
80BLK0.83689994
81CHEK20.83363295
82SIK30.82361313
83PLK30.81993117
84TESK20.81677929
85MAP3K30.81101966
86PBK0.81080881
87TBK10.80753949
88LRRK20.78290057
89LCK0.75142375
90CSF1R0.74524484
91NEK90.73515106
92MST40.73370373
93MAP3K110.73083347
94BRSK10.70796721
95PIK3CG0.67639777
96CDK60.66535694
97RPS6KA50.66264813
98MAP3K100.66177841
99MARK30.66143919
100LYN0.65241305
101TIE10.64304848
102AURKA0.63183512
103MAPKAPK50.61660698
104MAPK150.60969824
105BMPR20.60494247
106ATM0.59722035
107INSRR0.57527405
108PDK20.56432254
109CSK0.56270134
110ALK0.55472193
111CSNK2A10.54115431
112MAP2K60.54096302
113PAK40.53899680
114NUAK10.53842208
115CDK20.53584980
116CCNB10.53438767
117HCK0.52994455
118PRKCQ0.52176957
119CSNK2A20.51990617
120ADRBK10.50364948
121STK30.49519808
122LIMK10.48604356
123YES10.47524362
124GRK70.47513133
125NEK10.47512993
126DYRK20.45240708
127MELK0.44596599
128CLK10.43006182
129ERBB30.41855361
130TNIK0.41300386
131TGFBR20.40731676
132SCYL20.37783462
133MAP3K120.36427818
134PKN10.34190584
135MAPK130.33546016
136RIPK40.32652543

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.50914766
2Mismatch repair_Homo sapiens_hsa034303.80426074
3Ribosome_Homo sapiens_hsa030103.57564892
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07802873
5Oxidative phosphorylation_Homo sapiens_hsa001903.07568607
6Base excision repair_Homo sapiens_hsa034102.99878158
7* Spliceosome_Homo sapiens_hsa030402.83698637
8Homologous recombination_Homo sapiens_hsa034402.76587072
9Nucleotide excision repair_Homo sapiens_hsa034202.64171584
10Parkinsons disease_Homo sapiens_hsa050122.61238492
11RNA polymerase_Homo sapiens_hsa030202.59642808
12Proteasome_Homo sapiens_hsa030502.59599353
13RNA transport_Homo sapiens_hsa030132.32429946
14One carbon pool by folate_Homo sapiens_hsa006702.21924676
15Cell cycle_Homo sapiens_hsa041102.19137011
16Pyrimidine metabolism_Homo sapiens_hsa002402.15636510
17Primary immunodeficiency_Homo sapiens_hsa053402.12399620
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06465714
19Fanconi anemia pathway_Homo sapiens_hsa034602.04486259
20Non-homologous end-joining_Homo sapiens_hsa034502.01905853
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85362861
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77791354
23RNA degradation_Homo sapiens_hsa030181.72946205
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69205961
25Huntingtons disease_Homo sapiens_hsa050161.68028816
26Basal transcription factors_Homo sapiens_hsa030221.60688772
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53876350
28Alzheimers disease_Homo sapiens_hsa050101.53310300
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.52688536
30p53 signaling pathway_Homo sapiens_hsa041151.52136057
31Herpes simplex infection_Homo sapiens_hsa051681.50091342
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.49995604
33Antigen processing and presentation_Homo sapiens_hsa046121.48496472
34Measles_Homo sapiens_hsa051621.47960877
35Allograft rejection_Homo sapiens_hsa053301.38452373
36Epstein-Barr virus infection_Homo sapiens_hsa051691.33727461
37mRNA surveillance pathway_Homo sapiens_hsa030151.32674865
38Rheumatoid arthritis_Homo sapiens_hsa053231.28834291
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25108353
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14955321
41Legionellosis_Homo sapiens_hsa051341.13094087
42Leishmaniasis_Homo sapiens_hsa051401.10891495
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06789702
44Purine metabolism_Homo sapiens_hsa002301.04470603
45Systemic lupus erythematosus_Homo sapiens_hsa053221.03047673
46Phototransduction_Homo sapiens_hsa047441.02536465
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02312269
48Hematopoietic cell lineage_Homo sapiens_hsa046400.99715858
49T cell receptor signaling pathway_Homo sapiens_hsa046600.99493588
50Nitrogen metabolism_Homo sapiens_hsa009100.99091940
51Viral carcinogenesis_Homo sapiens_hsa052030.96218920
52HTLV-I infection_Homo sapiens_hsa051660.94389471
53Graft-versus-host disease_Homo sapiens_hsa053320.91477091
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90806966
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90047511
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89918345
57Autoimmune thyroid disease_Homo sapiens_hsa053200.89641027
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86184460
59Apoptosis_Homo sapiens_hsa042100.86051223
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83387176
61Cardiac muscle contraction_Homo sapiens_hsa042600.82849277
62Asthma_Homo sapiens_hsa053100.82341657
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.81734891
64Influenza A_Homo sapiens_hsa051640.81288445
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80044947
66B cell receptor signaling pathway_Homo sapiens_hsa046620.77021883
67Hepatitis B_Homo sapiens_hsa051610.76527417
68Acute myeloid leukemia_Homo sapiens_hsa052210.74227883
69Collecting duct acid secretion_Homo sapiens_hsa049660.73406753
70Osteoclast differentiation_Homo sapiens_hsa043800.72298454
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72083657
72Shigellosis_Homo sapiens_hsa051310.67793365
73Butanoate metabolism_Homo sapiens_hsa006500.63341342
74Propanoate metabolism_Homo sapiens_hsa006400.63163537
75Small cell lung cancer_Homo sapiens_hsa052220.62849568
76Linoleic acid metabolism_Homo sapiens_hsa005910.62764416
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62019396
78Chronic myeloid leukemia_Homo sapiens_hsa052200.61376445
79Protein export_Homo sapiens_hsa030600.60117736
80Staphylococcus aureus infection_Homo sapiens_hsa051500.57884999
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57388223
82TNF signaling pathway_Homo sapiens_hsa046680.55661646
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55393672
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55031831
85Toxoplasmosis_Homo sapiens_hsa051450.53968798
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52973126
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52004829
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51985927
89Viral myocarditis_Homo sapiens_hsa054160.51784164
90Type I diabetes mellitus_Homo sapiens_hsa049400.49869886
91Tryptophan metabolism_Homo sapiens_hsa003800.49509193
92Thyroid cancer_Homo sapiens_hsa052160.49237838
93Pentose phosphate pathway_Homo sapiens_hsa000300.46654600
94Selenocompound metabolism_Homo sapiens_hsa004500.46618305
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46306972
96Fatty acid elongation_Homo sapiens_hsa000620.46259672
97MicroRNAs in cancer_Homo sapiens_hsa052060.45712614
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45011044
99Metabolic pathways_Homo sapiens_hsa011000.42111368
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.40246319
101Sulfur relay system_Homo sapiens_hsa041220.39776631
102Colorectal cancer_Homo sapiens_hsa052100.38089995
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37452260
104Arachidonic acid metabolism_Homo sapiens_hsa005900.37133180
105Peroxisome_Homo sapiens_hsa041460.36973477
106Regulation of autophagy_Homo sapiens_hsa041400.36114913
107Pancreatic cancer_Homo sapiens_hsa052120.35881498
108Folate biosynthesis_Homo sapiens_hsa007900.34868066
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34283668
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34156958
111Notch signaling pathway_Homo sapiens_hsa043300.34035210
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33704663
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32261465
114Caffeine metabolism_Homo sapiens_hsa002320.31419043
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31397541
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31378642
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30394361
118Tuberculosis_Homo sapiens_hsa051520.30045513
119Pertussis_Homo sapiens_hsa051330.29900116
120Malaria_Homo sapiens_hsa051440.28673356
121N-Glycan biosynthesis_Homo sapiens_hsa005100.28190308
122Sulfur metabolism_Homo sapiens_hsa009200.27079162
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.27030456
124Non-small cell lung cancer_Homo sapiens_hsa052230.26763394
125HIF-1 signaling pathway_Homo sapiens_hsa040660.26261804
126Oocyte meiosis_Homo sapiens_hsa041140.25544803
127Prolactin signaling pathway_Homo sapiens_hsa049170.24526711
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24041103
129Chemokine signaling pathway_Homo sapiens_hsa040620.23675513
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.23587711
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21789019
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.21560223
133Hepatitis C_Homo sapiens_hsa051600.21497569
134Pathways in cancer_Homo sapiens_hsa052000.21297271
135FoxO signaling pathway_Homo sapiens_hsa040680.18774431
136Alcoholism_Homo sapiens_hsa050340.16842600
137Other glycan degradation_Homo sapiens_hsa005110.16813835

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