ISPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.81156688
2fucose catabolic process (GO:0019317)4.22272408
3L-fucose metabolic process (GO:0042354)4.22272408
4L-fucose catabolic process (GO:0042355)4.22272408
5DNA deamination (GO:0045006)4.17912686
6neuronal action potential propagation (GO:0019227)4.02195199
7synaptic vesicle exocytosis (GO:0016079)3.96326593
8neuron cell-cell adhesion (GO:0007158)3.88113154
9platelet dense granule organization (GO:0060155)3.84261538
10negative regulation of neurotransmitter transport (GO:0051589)3.76733138
11piRNA metabolic process (GO:0034587)3.75254512
12indolalkylamine metabolic process (GO:0006586)3.72575624
13negative regulation of neurotransmitter secretion (GO:0046929)3.63517657
14glutamate secretion (GO:0014047)3.51374134
15water-soluble vitamin biosynthetic process (GO:0042364)3.46975592
16protein localization to synapse (GO:0035418)3.44843834
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44774613
18regulation of synaptic vesicle exocytosis (GO:2000300)3.43483330
19fatty acid elongation (GO:0030497)3.41263381
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37346903
21kynurenine metabolic process (GO:0070189)3.35812650
22synaptic vesicle maturation (GO:0016188)3.35089946
23nonmotile primary cilium assembly (GO:0035058)3.32810559
24regulation of vesicle fusion (GO:0031338)3.32243977
25protein-cofactor linkage (GO:0018065)3.32043812
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31975707
27negative regulation of telomere maintenance (GO:0032205)3.30513511
28indolalkylamine catabolic process (GO:0046218)3.29469692
29tryptophan catabolic process (GO:0006569)3.29469692
30indole-containing compound catabolic process (GO:0042436)3.29469692
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28281213
32dopamine transport (GO:0015872)3.27487151
33preassembly of GPI anchor in ER membrane (GO:0016254)3.26602179
34cellular ketone body metabolic process (GO:0046950)3.25896515
35detection of light stimulus involved in sensory perception (GO:0050962)3.23699343
36detection of light stimulus involved in visual perception (GO:0050908)3.23699343
37detection of temperature stimulus involved in sensory perception (GO:0050961)3.19608275
38detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.19608275
39DNA methylation involved in gamete generation (GO:0043046)3.19135562
40substrate-independent telencephalic tangential migration (GO:0021826)3.19057226
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.19057226
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17623933
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.17623933
44NADH dehydrogenase complex assembly (GO:0010257)3.17623933
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15344452
46protein complex biogenesis (GO:0070271)3.12577543
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11227214
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09046488
49transmission of nerve impulse (GO:0019226)3.08345038
50indole-containing compound metabolic process (GO:0042430)3.07158311
51protein polyglutamylation (GO:0018095)3.07121736
52mating behavior (GO:0007617)3.05998067
53primary amino compound metabolic process (GO:1901160)3.05858093
54response to pheromone (GO:0019236)3.05742133
55exploration behavior (GO:0035640)3.05495905
56kidney morphogenesis (GO:0060993)3.05314828
57serotonin metabolic process (GO:0042428)3.03964130
58tryptophan metabolic process (GO:0006568)3.00558929
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.00237352
60long-term synaptic potentiation (GO:0060291)2.99976870
61ketone body metabolic process (GO:1902224)2.99629074
62cellular potassium ion homeostasis (GO:0030007)2.99122826
63ionotropic glutamate receptor signaling pathway (GO:0035235)2.98480343
64apical protein localization (GO:0045176)2.97689361
65retinal cone cell development (GO:0046549)2.94820945
66presynaptic membrane assembly (GO:0097105)2.92338935
67regulation of glutamate secretion (GO:0014048)2.92186354
68neurotransmitter secretion (GO:0007269)2.91936536
69vocalization behavior (GO:0071625)2.89644144
70detection of calcium ion (GO:0005513)2.89229948
71neuron recognition (GO:0008038)2.87215341
72synaptic transmission, glutamatergic (GO:0035249)2.86208888
73neuron-neuron synaptic transmission (GO:0007270)2.85507712
74central nervous system myelination (GO:0022010)2.84006938
75axon ensheathment in central nervous system (GO:0032291)2.84006938
76locomotory exploration behavior (GO:0035641)2.83160976
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82680529
78respiratory chain complex IV assembly (GO:0008535)2.82017448
79mitochondrial respiratory chain complex assembly (GO:0033108)2.81888071
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81388660
81cornea development in camera-type eye (GO:0061303)2.81184974
82glutamate receptor signaling pathway (GO:0007215)2.81092183
83regulation of glucokinase activity (GO:0033131)2.80335914
84regulation of hexokinase activity (GO:1903299)2.80335914
85epithelial cilium movement (GO:0003351)2.79750524
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78046891
87gamma-aminobutyric acid transport (GO:0015812)2.77104540
88ubiquinone biosynthetic process (GO:0006744)2.76150829
89regulation of synaptic vesicle transport (GO:1902803)2.75695721
90positive regulation of potassium ion transport (GO:0043268)2.74849413
91myelination (GO:0042552)2.74740302
92multicellular organism reproduction (GO:0032504)2.74401481
93regulation of mesoderm development (GO:2000380)2.73553896
94neural tube formation (GO:0001841)2.73021953
95regulation of glucocorticoid secretion (GO:2000849)2.72768718
96rRNA catabolic process (GO:0016075)2.72757322
97axon ensheathment (GO:0008366)2.71534170
98ensheathment of neurons (GO:0007272)2.71534170
99detection of temperature stimulus (GO:0016048)2.69862817
100long-chain fatty acid biosynthetic process (GO:0042759)2.68185565
101sulfation (GO:0051923)2.67749881
102behavioral response to ethanol (GO:0048149)2.67227186
103axoneme assembly (GO:0035082)2.66839058
104presynaptic membrane organization (GO:0097090)2.65115485
105innervation (GO:0060384)2.64718737
106protein K6-linked ubiquitination (GO:0085020)2.64628686
107positive regulation of fatty acid transport (GO:2000193)2.63166612
108regulation of neurotransmitter uptake (GO:0051580)2.63136363
109potassium ion homeostasis (GO:0055075)2.62829815
110RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62122448
111regulation of voltage-gated calcium channel activity (GO:1901385)2.61879674
112ATP hydrolysis coupled proton transport (GO:0015991)2.61293931
113energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61293931
114cellular response to ATP (GO:0071318)2.61047450
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60880352
116axonal fasciculation (GO:0007413)2.59306911
117regulation of neuronal synaptic plasticity (GO:0048168)2.59144439
118regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.58749266
119regulation of meiosis I (GO:0060631)2.58237173
120ubiquinone metabolic process (GO:0006743)2.58213749
121reciprocal meiotic recombination (GO:0007131)2.57846827
122reciprocal DNA recombination (GO:0035825)2.57846827
123cAMP catabolic process (GO:0006198)2.57110673
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57043029
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57043029
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56909704
127regulation of glutamate receptor signaling pathway (GO:1900449)2.56465895
128dendrite morphogenesis (GO:0048813)2.56012005
129rhodopsin mediated signaling pathway (GO:0016056)2.56007396
130reflex (GO:0060004)2.55583888
131positive regulation of potassium ion transmembrane transport (GO:1901381)2.55401001
132GPI anchor metabolic process (GO:0006505)2.55201018
133photoreceptor cell development (GO:0042461)2.54539677
134synaptic transmission, cholinergic (GO:0007271)2.54512069
135positive regulation of synapse assembly (GO:0051965)2.54194872
136male meiosis I (GO:0007141)2.54177316
137centriole replication (GO:0007099)2.52633694
138pyrimidine nucleobase catabolic process (GO:0006208)2.51672968
139negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51377091
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.50910776
141protein K11-linked deubiquitination (GO:0035871)2.50238241
142cytochrome complex assembly (GO:0017004)2.50067640
143response to methylmercury (GO:0051597)2.49657184
144synaptic vesicle endocytosis (GO:0048488)2.49638018
145male meiosis (GO:0007140)2.48862457
146negative regulation of synaptic transmission (GO:0050805)2.47810884
147neurotransmitter transport (GO:0006836)2.47728883
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47704059
149phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.47347249
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.47130745
151amine catabolic process (GO:0009310)2.46824040
152cellular biogenic amine catabolic process (GO:0042402)2.46824040
153regulation of action potential (GO:0098900)2.46769682
154proline transport (GO:0015824)2.46594868
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.46163472
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45971360
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45756496
158photoreceptor cell maintenance (GO:0045494)2.45310908
159nephron tubule morphogenesis (GO:0072078)2.45204835
160nephron epithelium morphogenesis (GO:0072088)2.45204835
161somite development (GO:0061053)2.44412447
162membrane hyperpolarization (GO:0060081)2.43908673
163oligodendrocyte differentiation (GO:0048709)2.43811944
164cilium organization (GO:0044782)2.43713745
165adult walking behavior (GO:0007628)2.43320822
166regulation of cilium movement (GO:0003352)2.43051136
167negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.42024453
168regulation of neurotransmitter secretion (GO:0046928)2.41770177
169pyrimidine ribonucleoside catabolic process (GO:0046133)2.41766291
170cell communication by electrical coupling (GO:0010644)2.40831415
171regulation of hippo signaling (GO:0035330)2.40479246
172regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40294011
173regulation of neurotransmitter transport (GO:0051588)2.40138903
174parturition (GO:0007567)2.39910805
175endoderm formation (GO:0001706)2.39899723
176cilium morphogenesis (GO:0060271)2.39460689
177nucleobase catabolic process (GO:0046113)2.39189938
178negative regulation of mast cell activation (GO:0033004)2.38881606
179cholesterol biosynthetic process (GO:0006695)2.38761347
180regulation of synapse structural plasticity (GO:0051823)2.38628698
181positive regulation of amino acid transport (GO:0051957)2.38428748
182negative regulation of amino acid transport (GO:0051956)2.37788319
183synapse assembly (GO:0007416)2.37445796
184iron coordination entity transport (GO:1901678)2.36542316
185regulation of synaptic transmission, glutamatergic (GO:0051966)2.36446316
186synapse organization (GO:0050808)2.36006978
187regulation of dendritic spine morphogenesis (GO:0061001)2.35679351
188regulation of neurotransmitter levels (GO:0001505)2.32458081
189synaptic vesicle docking involved in exocytosis (GO:0016081)2.32238818
190cerebral cortex radially oriented cell migration (GO:0021799)2.30265139
191neuronal action potential (GO:0019228)2.30244533
192substantia nigra development (GO:0021762)2.28922954
193negative regulation of cation channel activity (GO:2001258)2.28663999
194postsynaptic membrane organization (GO:0001941)2.27273341
195positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.26377098
196neurotransmitter catabolic process (GO:0042135)2.26103046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.56962948
2EZH2_22144423_ChIP-Seq_EOC_Human4.04216669
3TAF15_26573619_Chip-Seq_HEK293_Human3.04266001
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98770374
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94643295
6AR_21572438_ChIP-Seq_LNCaP_Human2.69201241
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52835926
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49471399
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48331496
10IGF1R_20145208_ChIP-Seq_DFB_Human2.43770915
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42689438
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42689438
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41092862
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39335059
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.39130261
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37972968
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37074843
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36043475
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.11512769
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07940249
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.07344000
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05521637
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03698482
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02778130
25REST_21632747_ChIP-Seq_MESCs_Mouse1.98303106
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95193463
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88705597
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.82888972
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81150767
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80980108
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80506025
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.73962189
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72576092
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72239046
35DROSHA_22980978_ChIP-Seq_HELA_Human1.71782114
36SMAD4_21799915_ChIP-Seq_A2780_Human1.68418737
37P300_19829295_ChIP-Seq_ESCs_Human1.67810168
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.66715387
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.65415816
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65014607
41IRF1_19129219_ChIP-ChIP_H3396_Human1.64025980
42ZNF274_21170338_ChIP-Seq_K562_Hela1.63579289
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63232565
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62036312
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61737932
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.61438731
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60751090
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59933258
49TP53_22573176_ChIP-Seq_HFKS_Human1.58790452
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57573519
51FUS_26573619_Chip-Seq_HEK293_Human1.53709552
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52342772
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50284865
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49602243
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.49160067
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.48846316
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46944389
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45156070
59* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44412593
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43482758
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43440660
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.43354237
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.43284480
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.42523331
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41003577
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40827620
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.38308686
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.37895192
69NANOG_19829295_ChIP-Seq_ESCs_Human1.37161042
70SOX2_19829295_ChIP-Seq_ESCs_Human1.37161042
71MYC_18940864_ChIP-ChIP_HL60_Human1.37116894
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35760098
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.32836626
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32836626
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32467258
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31109802
77ER_23166858_ChIP-Seq_MCF-7_Human1.26551509
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.26326630
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26183113
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26183113
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25833978
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.24773608
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23889884
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22174728
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21816645
86RNF2_27304074_Chip-Seq_NSC_Mouse1.21175088
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.19606201
88STAT3_23295773_ChIP-Seq_U87_Human1.19327511
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.18720554
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18532544
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18317313
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.17986049
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17964134
94JUN_21703547_ChIP-Seq_K562_Human1.17640042
95* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17606083
96AR_25329375_ChIP-Seq_VCAP_Human1.17387626
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15891978
98VDR_22108803_ChIP-Seq_LS180_Human1.15837918
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15703285
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13179656
101AR_20517297_ChIP-Seq_VCAP_Human1.12637793
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.12526410
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11145225
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10660334
105* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10326282
106* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09874079
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.09626587
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09562229
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08933467
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08933467
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08819570
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08548980
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07755983
114CBP_20019798_ChIP-Seq_JUKART_Human1.07755983
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.06842169
116RUNX2_22187159_ChIP-Seq_PCA_Human1.06718243
117HOXB7_26014856_ChIP-Seq_BT474_Human1.06212447
118NCOR_22424771_ChIP-Seq_293T_Human1.06203399
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03828237
120AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03724089
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02037692
122BCAT_22108803_ChIP-Seq_LS180_Human1.01766979
123P53_22387025_ChIP-Seq_ESCs_Mouse1.01519102
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01491648
125TCF4_23295773_ChIP-Seq_U87_Human1.00925848
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00437757
127* CRX_20693478_ChIP-Seq_RETINA_Mouse1.00361930
128* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99471977
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99420220
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98796996
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.98046161
132TCF4_22108803_ChIP-Seq_LS180_Human0.97943622
133CDX2_22108803_ChIP-Seq_LS180_Human0.97032457
134ELK1_19687146_ChIP-ChIP_HELA_Human0.96160915
135AHR_22903824_ChIP-Seq_MCF-7_Human0.96031145
136* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95649617
137* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95258731
138VDR_23849224_ChIP-Seq_CD4+_Human0.95136285
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.95005972
140AR_19668381_ChIP-Seq_PC3_Human0.94283312
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93606745
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.91327297
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90819514
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.90265134
145KDM2B_26808549_Chip-Seq_REH_Human0.89939892
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89655313
147EWS_26573619_Chip-Seq_HEK293_Human0.89004046
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88907796
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.88556984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.02833633
2MP0003880_abnormal_central_pattern3.98835183
3MP0004859_abnormal_synaptic_plasticity3.90270153
4MP0008877_abnormal_DNA_methylation3.11807391
5MP0004270_analgesia3.04340334
6MP0002102_abnormal_ear_morphology2.87597702
7MP0002736_abnormal_nociception_after2.83152976
8MP0003635_abnormal_synaptic_transmissio2.77389551
9MP0002735_abnormal_chemical_nociception2.65966047
10MP0003195_calcinosis2.59669593
11MP0002064_seizures2.45143723
12MP0003646_muscle_fatigue2.45074306
13MP0005646_abnormal_pituitary_gland2.42247119
14MP0009745_abnormal_behavioral_response2.40635526
15MP0002272_abnormal_nervous_system2.32847028
16MP0006276_abnormal_autonomic_nervous2.24752718
17MP0000569_abnormal_digit_pigmentation2.24593800
18MP0004142_abnormal_muscle_tone2.20379430
19MP0009046_muscle_twitch2.17787571
20MP0002063_abnormal_learning/memory/cond2.15969689
21MP0000920_abnormal_myelination2.15294633
22MP0008872_abnormal_physiological_respon2.13295351
23MP0006292_abnormal_olfactory_placode2.12858862
24MP0001905_abnormal_dopamine_level2.12665201
25MP0002837_dystrophic_cardiac_calcinosis2.11358698
26MP0002572_abnormal_emotion/affect_behav2.02295213
27MP0005645_abnormal_hypothalamus_physiol2.01417107
28MP0002067_abnormal_sensory_capabilities2.00838502
29MP0000372_irregular_coat_pigmentation1.99518293
30MP0003122_maternal_imprinting1.94166549
31MP0002733_abnormal_thermal_nociception1.91596413
32MP0002734_abnormal_mechanical_nocicepti1.90145618
33MP0003329_amyloid_beta_deposits1.89735192
34MP0001486_abnormal_startle_reflex1.85908612
35MP0002822_catalepsy1.83221563
36MP0000778_abnormal_nervous_system1.81360590
37MP0001986_abnormal_taste_sensitivity1.74623535
38MP0004924_abnormal_behavior1.73843769
39MP0005386_behavior/neurological_phenoty1.73843769
40MP0003011_delayed_dark_adaptation1.71773818
41MP0003787_abnormal_imprinting1.71232898
42MP0002184_abnormal_innervation1.68303401
43MP0005551_abnormal_eye_electrophysiolog1.64717617
44MP0003634_abnormal_glial_cell1.63023485
45MP0001970_abnormal_pain_threshold1.60754957
46MP0004858_abnormal_nervous_system1.60322823
47MP0002638_abnormal_pupillary_reflex1.60061869
48MP0005171_absent_coat_pigmentation1.59525452
49MP0003718_maternal_effect1.59321234
50MP0002876_abnormal_thyroid_physiology1.57345111
51MP0000751_myopathy1.55358036
52MP0003283_abnormal_digestive_organ1.53635731
53MP0002557_abnormal_social/conspecific_i1.48451694
54MP0004133_heterotaxia1.48438740
55MP0000955_abnormal_spinal_cord1.48111360
56MP0001485_abnormal_pinna_reflex1.47853879
57MP0005174_abnormal_tail_pigmentation1.47531946
58MP0005084_abnormal_gallbladder_morpholo1.45747345
59MP0000427_abnormal_hair_cycle1.44034474
60MP0001501_abnormal_sleep_pattern1.38751738
61MP0004742_abnormal_vestibular_system1.38703916
62MP0002234_abnormal_pharynx_morphology1.36660968
63MP0002909_abnormal_adrenal_gland1.35326174
64MP0001440_abnormal_grooming_behavior1.34705118
65MP0004134_abnormal_chest_morphology1.34214908
66MP0003690_abnormal_glial_cell1.31205447
67MP0002938_white_spotting1.30704954
68MP0002882_abnormal_neuron_morphology1.28690980
69MP0002160_abnormal_reproductive_system1.28473624
70MP0005389_reproductive_system_phenotype1.27049809
71MP0004885_abnormal_endolymph1.26705255
72MP0001502_abnormal_circadian_rhythm1.26681231
73MP0008058_abnormal_DNA_repair1.24639958
74MP0004272_abnormal_basement_membrane1.22017264
75MP0002066_abnormal_motor_capabilities/c1.21258130
76MP0004811_abnormal_neuron_physiology1.21112165
77MP0005423_abnormal_somatic_nervous1.20950265
78MP0002139_abnormal_hepatobiliary_system1.20401429
79MP0000383_abnormal_hair_follicle1.19794431
80MP0003136_yellow_coat_color1.19650530
81MP0002229_neurodegeneration1.16717222
82MP0000013_abnormal_adipose_tissue1.15380039
83MP0006072_abnormal_retinal_apoptosis1.15339478
84MP0002928_abnormal_bile_duct1.13671021
85MP0001188_hyperpigmentation1.13641155
86MP0005623_abnormal_meninges_morphology1.12928174
87MP0002653_abnormal_ependyma_morphology1.12593046
88MP0008569_lethality_at_weaning1.11274686
89MP0003890_abnormal_embryonic-extraembry1.10424593
90MP0001299_abnormal_eye_distance/1.10141257
91MP0000639_abnormal_adrenal_gland1.09787370
92MP0005167_abnormal_blood-brain_barrier1.06992960
93MP0002090_abnormal_vision1.06242709
94MP0004036_abnormal_muscle_relaxation1.05296287
95MP0008875_abnormal_xenobiotic_pharmacok1.05228281
96MP0003633_abnormal_nervous_system1.03457848
97MP0005195_abnormal_posterior_eye1.02423831
98MP0010386_abnormal_urinary_bladder1.02343950
99MP0001919_abnormal_reproductive_system1.02340214
100MP0000534_abnormal_ureter_morphology1.01101608
101MP0001984_abnormal_olfaction1.01026140
102MP0003119_abnormal_digestive_system1.00269339
103MP0003632_abnormal_nervous_system1.00237459
104MP0001661_extended_life_span0.98543340
105MP0000631_abnormal_neuroendocrine_gland0.97582145
106MP0003631_nervous_system_phenotype0.97553262
107MP0004215_abnormal_myocardial_fiber0.97302229
108MP0005595_abnormal_vascular_smooth0.97283902
109MP0000747_muscle_weakness0.96485119
110MP0008995_early_reproductive_senescence0.96255704
111MP0009250_abnormal_appendicular_skeleto0.94489617
112MP0005085_abnormal_gallbladder_physiolo0.94366947
113MP0005075_abnormal_melanosome_morpholog0.94141581
114MP0002095_abnormal_skin_pigmentation0.92997551
115MP0003252_abnormal_bile_duct0.92612012
116MP0000749_muscle_degeneration0.92393796
117MP0004145_abnormal_muscle_electrophysio0.92257289
118MP0003123_paternal_imprinting0.91275564
119MP0000604_amyloidosis0.91244968
120MP0002138_abnormal_hepatobiliary_system0.89764600
121MP0002751_abnormal_autonomic_nervous0.87578908
122MP0005083_abnormal_biliary_tract0.86905542
123MP0000462_abnormal_digestive_system0.86765735
124MP0005253_abnormal_eye_physiology0.86447699
125MP0005332_abnormal_amino_acid0.84718847
126MP0001177_atelectasis0.84476087
127MP0001529_abnormal_vocalization0.83609884
128MP0002752_abnormal_somatic_nervous0.83389634
129MP0005410_abnormal_fertilization0.83376134
130MP0003137_abnormal_impulse_conducting0.83066367
131MP0004147_increased_porphyrin_level0.82504372
132MP0004085_abnormal_heartbeat0.82452346
133MP0003698_abnormal_male_reproductive0.82435819
134MP0000230_abnormal_systemic_arterial0.80187338
135MP0001929_abnormal_gametogenesis0.80036235
136MP0000428_abnormal_craniofacial_morphol0.78351238
137MP0003385_abnormal_body_wall0.78117772
138MP0001958_emphysema0.77614275
139MP0002069_abnormal_eating/drinking_beha0.77282308
140MP0002152_abnormal_brain_morphology0.76248440
141MP0008438_abnormal_cutaneous_collagen0.76202722
142MP0009780_abnormal_chondrocyte_physiolo0.75941899
143MP0003121_genomic_imprinting0.75645275
144MP0001764_abnormal_homeostasis0.75603166
145MP0002163_abnormal_gland_morphology0.75367737
146MP0009697_abnormal_copulation0.74658888
147MP0000026_abnormal_inner_ear0.74173686
148MP0001963_abnormal_hearing_physiology0.70852948
149MP0008775_abnormal_heart_ventricle0.70330624
150MP0004043_abnormal_pH_regulation0.66200092
151MP0005257_abnormal_intraocular_pressure0.66025667
152MP0004084_abnormal_cardiac_muscle0.64819024

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.63362664
2Pancreatic cysts (HP:0001737)4.43100085
3Myokymia (HP:0002411)4.42429401
4Pancreatic fibrosis (HP:0100732)4.15068057
5Molar tooth sign on MRI (HP:0002419)3.86557255
6Abnormality of midbrain morphology (HP:0002418)3.86557255
7Hypoglycemic seizures (HP:0002173)3.82930681
8True hermaphroditism (HP:0010459)3.73862641
9Pheochromocytoma (HP:0002666)3.69360255
10Ulnar claw (HP:0001178)3.60167127
11Abnormality of the renal cortex (HP:0011035)3.58081659
12Nephronophthisis (HP:0000090)3.56560733
13Neuroendocrine neoplasm (HP:0100634)3.48348953
14Neurofibrillary tangles (HP:0002185)3.45124179
15Abnormality of the corticospinal tract (HP:0002492)3.34755971
16Epileptic encephalopathy (HP:0200134)3.32266546
17Abnormality of macular pigmentation (HP:0008002)3.19583649
18* Retinal dysplasia (HP:0007973)3.16432037
19Abnormality of the renal medulla (HP:0100957)3.12405115
20Segmental peripheral demyelination/remyelination (HP:0003481)3.04226451
21Renal cortical cysts (HP:0000803)3.01862751
22Pendular nystagmus (HP:0012043)2.92603549
23Focal seizures (HP:0007359)2.90745560
24Atonic seizures (HP:0010819)2.89797375
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88915108
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.88915108
27Inability to walk (HP:0002540)2.83409168
28Symptomatic seizures (HP:0011145)2.82567810
29Attenuation of retinal blood vessels (HP:0007843)2.81400976
30Abolished electroretinogram (ERG) (HP:0000550)2.81321956
31Termporal pattern (HP:0011008)2.80687659
32Insidious onset (HP:0003587)2.80687659
33Neoplasm of the peripheral nervous system (HP:0100007)2.80558345
34Poor suck (HP:0002033)2.78211598
35* Type II lissencephaly (HP:0007260)2.77410814
36Central scotoma (HP:0000603)2.74789569
37Supranuclear gaze palsy (HP:0000605)2.70463375
38Chronic hepatic failure (HP:0100626)2.69575005
39Increased corneal curvature (HP:0100692)2.68833850
40Keratoconus (HP:0000563)2.68833850
41Abnormal rod and cone electroretinograms (HP:0008323)2.68481899
42Cerebral inclusion bodies (HP:0100314)2.66912163
43Progressive inability to walk (HP:0002505)2.65987002
44Absence seizures (HP:0002121)2.65595168
45Tubular atrophy (HP:0000092)2.63240423
46Action tremor (HP:0002345)2.62147362
47Polyphagia (HP:0002591)2.57790705
48Cystic liver disease (HP:0006706)2.56046097
49Visual hallucinations (HP:0002367)2.52215455
50Steppage gait (HP:0003376)2.50030907
51Abnormal eating behavior (HP:0100738)2.46820357
52Onion bulb formation (HP:0003383)2.46376084
53Dialeptic seizures (HP:0011146)2.44327151
54Congenital, generalized hypertrichosis (HP:0004540)2.43578205
55Polydipsia (HP:0001959)2.42540700
56Abnormal drinking behavior (HP:0030082)2.42540700
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42526100
58Abnormality of alanine metabolism (HP:0010916)2.42526100
59Hyperalaninemia (HP:0003348)2.42526100
60Spastic gait (HP:0002064)2.41053023
61Dysmetria (HP:0001310)2.40471813
62Hyperventilation (HP:0002883)2.39363416
63Failure to thrive in infancy (HP:0001531)2.38614758
64Decreased central vision (HP:0007663)2.35103577
65Generalized tonic-clonic seizures (HP:0002069)2.33572921
66Sclerocornea (HP:0000647)2.32896155
67Axonal loss (HP:0003447)2.31869389
68Cerebellar dysplasia (HP:0007033)2.27958826
69Prolonged QT interval (HP:0001657)2.27857287
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.27665621
71Absent/shortened dynein arms (HP:0200106)2.27144840
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.27144840
73Akinesia (HP:0002304)2.26909121
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25979001
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.22608764
76Hammertoe (HP:0001765)2.22210568
77Increased CSF lactate (HP:0002490)2.21538121
78Anencephaly (HP:0002323)2.20837075
79Furrowed tongue (HP:0000221)2.20219159
80Birth length less than 3rd percentile (HP:0003561)2.19982663
81Mitochondrial inheritance (HP:0001427)2.19264994
82Progressive cerebellar ataxia (HP:0002073)2.18877203
83Stomach cancer (HP:0012126)2.17723372
84Drooling (HP:0002307)2.17703847
85Excessive salivation (HP:0003781)2.17703847
86Progressive macrocephaly (HP:0004481)2.17090632
87Intestinal atresia (HP:0011100)2.16102969
88Upper limb muscle weakness (HP:0003484)2.15645983
89Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.15368852
90Neoplasm of head and neck (HP:0012288)2.13104655
91Esophageal neoplasm (HP:0100751)2.13104655
92Methylmalonic acidemia (HP:0002912)2.12918950
93Abnormal biliary tract physiology (HP:0012439)2.12436662
94Bile duct proliferation (HP:0001408)2.12436662
95Urinary urgency (HP:0000012)2.11414134
96Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10339826
97Mutism (HP:0002300)2.08446213
98Abnormality of the pons (HP:0007361)2.07924570
99Bronchomalacia (HP:0002780)2.07695926
100Anxiety (HP:0000739)2.07233996
101Peripheral hypomyelination (HP:0007182)2.06653377
102Hypothermia (HP:0002045)2.06351440
103Fetal akinesia sequence (HP:0001989)2.06081498
104Oligodactyly (hands) (HP:0001180)2.05220905
105Optic disc pallor (HP:0000543)2.02780661
106Congenital hepatic fibrosis (HP:0002612)2.01934793
107Nephrogenic diabetes insipidus (HP:0009806)2.01730801
108Patellar aplasia (HP:0006443)2.00997911
109* Lissencephaly (HP:0001339)2.00369934
110Genetic anticipation (HP:0003743)1.99116696
111Aplasia/Hypoplasia of the patella (HP:0006498)1.98873475
112Scanning speech (HP:0002168)1.98541442
113Hypoplasia of the pons (HP:0012110)1.98517396
114Broad-based gait (HP:0002136)1.98258833
115Chorioretinal atrophy (HP:0000533)1.98237420
1163-Methylglutaconic aciduria (HP:0003535)1.98162624
117Specific learning disability (HP:0001328)1.97890515
118Epileptiform EEG discharges (HP:0011182)1.97385729
119Febrile seizures (HP:0002373)1.96666110
120Septo-optic dysplasia (HP:0100842)1.96584344
121Generalized myoclonic seizures (HP:0002123)1.96318622
122Large for gestational age (HP:0001520)1.96149946
123Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96130005
124Fair hair (HP:0002286)1.95210307
125Polyuria (HP:0000103)1.94547685
126EEG with generalized epileptiform discharges (HP:0011198)1.92411574
127Hepatic necrosis (HP:0002605)1.92139663
128Gait imbalance (HP:0002141)1.92002755
129Congenital stationary night blindness (HP:0007642)1.90581907
130Intention tremor (HP:0002080)1.90126273
131Aplasia/hypoplasia of the uterus (HP:0008684)1.90072427
132Hemiparesis (HP:0001269)1.90065397
133Ankle clonus (HP:0011448)1.89608490
134Protruding tongue (HP:0010808)1.89525005
135Genital tract atresia (HP:0001827)1.88494763
136Acute necrotizing encephalopathy (HP:0006965)1.87888106
137Dysdiadochokinesis (HP:0002075)1.87407011
138Short tibia (HP:0005736)1.87363345
139Male pseudohermaphroditism (HP:0000037)1.87258206
140Concave nail (HP:0001598)1.87074880
141Blue irides (HP:0000635)1.86664822
142Distal sensory impairment (HP:0002936)1.86272805
143Postaxial foot polydactyly (HP:0001830)1.86218670
144Severe visual impairment (HP:0001141)1.86165185
145Abnormal mitochondria in muscle tissue (HP:0008316)1.85419995
146Methylmalonic aciduria (HP:0012120)1.84072193
147Abnormal respiratory epithelium morphology (HP:0012253)1.81953420
148Abnormal respiratory motile cilium morphology (HP:0005938)1.81953420
149Acute encephalopathy (HP:0006846)1.81620946
150Vaginal atresia (HP:0000148)1.81593540
151Bony spicule pigmentary retinopathy (HP:0007737)1.81574942
152Limb dystonia (HP:0002451)1.81482538
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.80766612
154Hypoplasia of the fovea (HP:0007750)1.80516189
155Aplasia/Hypoplasia of the fovea (HP:0008060)1.80516189
156Hepatocellular necrosis (HP:0001404)1.79886373
157Spastic tetraplegia (HP:0002510)1.78853319
158Abnormal hair whorl (HP:0010721)1.78088872
159Congenital sensorineural hearing impairment (HP:0008527)1.77849233
160Small hand (HP:0200055)1.77225066
161Abnormal ciliary motility (HP:0012262)1.77160646
162Dysautonomia (HP:0002459)1.76000889
163Hypsarrhythmia (HP:0002521)1.75940269
164* Pachygyria (HP:0001302)1.74881571
165Severe muscular hypotonia (HP:0006829)1.74431197
166Hypoplastic left heart (HP:0004383)1.74316640
167Scotoma (HP:0000575)1.73322327
168Congenital primary aphakia (HP:0007707)1.71693562
169Gaze-evoked nystagmus (HP:0000640)1.68833034
170Abnormality of glycolysis (HP:0004366)1.68813928
171Increased serum pyruvate (HP:0003542)1.68813928
172Aplasia involving bones of the upper limbs (HP:0009823)1.68431598
173Aplasia of the phalanges of the hand (HP:0009802)1.68431598
174Aplasia involving bones of the extremities (HP:0009825)1.68431598
175Psychosis (HP:0000709)1.67605481
176Tetraplegia (HP:0002445)1.67277134
177Medial flaring of the eyebrow (HP:0010747)1.66892127
178Increased circulating renin level (HP:0000848)1.66328282
179Abnormality of the parathyroid morphology (HP:0011766)1.65601174
180Cerebral hemorrhage (HP:0001342)1.64268405
181Bundle branch block (HP:0011710)1.62054294
182Progressive external ophthalmoplegia (HP:0000590)1.61983387
183Morphological abnormality of the pyramidal tract (HP:0002062)1.60934066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.92104165
2NTRK33.59420606
3TAOK33.20078032
4ADRBK23.06190823
5MAP3K42.95778402
6MAP3K122.84913768
7ACVR1B2.78896725
8PDGFRA2.73641394
9ZAK2.71935542
10TNIK2.59586341
11MAP3K92.55477768
12GRK12.51988454
13EPHA42.51384924
14MAP4K22.50166894
15PINK12.49230034
16STK392.31570290
17CASK2.28411857
18PAK62.25702391
19NUAK12.12122263
20MINK12.05222322
21KSR21.92296779
22NTRK11.88129791
23OXSR11.83624553
24TLK11.78931067
25MUSK1.76433810
26PRKD31.70849709
27MAPK131.70665192
28EIF2AK31.70144766
29MAP3K21.61575623
30TNK21.60231602
31PHKG21.57722818
32PHKG11.57722818
33MAP2K71.57224184
34LMTK21.56881995
35MAP2K41.48565727
36BCKDK1.43194676
37CDK191.37589432
38TXK1.37569760
39FES1.34054515
40PLK21.32904528
41MARK11.32580647
42BCR1.19053490
43GRK51.18890082
44CSNK1G21.18673167
45ARAF1.17975148
46TGFBR11.17438728
47TRIM281.15702622
48WNK41.15311518
49UHMK11.15151211
50CAMK2A1.13679168
51CDK51.10922822
52MKNK21.09903781
53PDGFRB1.09849729
54TIE11.08139252
55FER1.07546133
56EIF2AK11.05010877
57PAK31.04849685
58NME11.04046577
59PRKCG1.00553021
60CDK141.00274823
61DYRK20.99562132
62MAPKAPK50.97347466
63VRK10.96565242
64SGK4940.95606691
65SGK2230.95606691
66KSR10.95605213
67ROCK20.95069216
68RIPK40.93926776
69CAMK2B0.93743408
70MAP3K130.93325067
71STK240.93290161
72MAPKAPK30.91261505
73CAMK2D0.88203624
74CSNK1G30.85817635
75OBSCN0.85175727
76IRAK20.82059728
77NEK60.81225726
78LIMK10.81195141
79PRKCH0.80719572
80CDK180.80170659
81TYRO30.79606645
82DAPK20.79596323
83DDR20.79328782
84CDK150.78922345
85MAP2K10.78672543
86FGR0.77900593
87TEC0.75918474
88CDK80.75450747
89STK38L0.73423353
90BRSK20.72652935
91PKN10.71838320
92MAPK120.71509673
93PNCK0.70929796
94CAMKK20.69770403
95CAMK2G0.69424793
96PRKCE0.68855846
97CDK11A0.68234400
98PLK30.66908375
99PIK3CA0.65875502
100PRPF4B0.64697179
101WNK10.64674870
102BMPR20.64608861
103PTK2B0.64263250
104PRKG20.63350690
105STK160.61986981
106IRAK10.61985631
107PRKCI0.61001468
108PLK40.59787926
109CSNK1G10.57767659
110GRK70.57558156
111IKBKB0.57311999
112PRKCQ0.57129754
113DYRK1A0.56859323
114NTRK20.56453672
115VRK20.56420263
116NEK20.55872789
117RPS6KA50.55202048
118CCNB10.54869159
119CSNK1A1L0.53951516
120ROCK10.52464956
121BMX0.51456560
122FLT30.51037978
123BMPR1B0.50575211
124MAPK150.48977930
125CAMK10.48916586
126FGFR20.47320055
127CSNK1A10.46423320
128TRPM70.45735015
129WNK30.45615281
130PRKACA0.45469154
131DAPK10.45366902
132KIT0.45229545
133MAP2K60.44176295
134ERBB30.43648130
135TSSK60.42026628
136ADRBK10.41407948
137RET0.39776097
138MAPK100.39262820
139PRKCZ0.38648742
140MET0.38597886
141PRKCA0.38597068
142CHEK20.38561619
143CHUK0.37457180
144INSRR0.37452559
145MST40.37126110
146FYN0.36294941
147STK110.33652556
148CSNK1D0.33395480
149PRKG10.33321749
150PLK10.32797074
151STK30.32271424
152IGF1R0.31032085
153PRKAA10.30509348
154WEE10.30125199
155MKNK10.30093459

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.82212704
2Nitrogen metabolism_Homo sapiens_hsa009102.69033190
3Nicotine addiction_Homo sapiens_hsa050332.64460088
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52663001
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.43636792
6GABAergic synapse_Homo sapiens_hsa047272.41552327
7Linoleic acid metabolism_Homo sapiens_hsa005912.35097218
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25647746
9Sulfur relay system_Homo sapiens_hsa041222.18020902
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14893231
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13905171
12Collecting duct acid secretion_Homo sapiens_hsa049662.06238393
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00616150
14Circadian entrainment_Homo sapiens_hsa047131.99706148
15Homologous recombination_Homo sapiens_hsa034401.98421974
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96763004
17Steroid biosynthesis_Homo sapiens_hsa001001.95858059
18Protein export_Homo sapiens_hsa030601.90953839
19Basal transcription factors_Homo sapiens_hsa030221.90667542
20Oxidative phosphorylation_Homo sapiens_hsa001901.89378417
21Glutamatergic synapse_Homo sapiens_hsa047241.83922546
22Selenocompound metabolism_Homo sapiens_hsa004501.81405782
23Tryptophan metabolism_Homo sapiens_hsa003801.81376143
24Morphine addiction_Homo sapiens_hsa050321.79859535
25Insulin secretion_Homo sapiens_hsa049111.76785584
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71732225
27Serotonergic synapse_Homo sapiens_hsa047261.71708626
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70184262
29Amphetamine addiction_Homo sapiens_hsa050311.69713700
30Fatty acid elongation_Homo sapiens_hsa000621.61235809
31Fanconi anemia pathway_Homo sapiens_hsa034601.61037424
32RNA polymerase_Homo sapiens_hsa030201.60698494
33Salivary secretion_Homo sapiens_hsa049701.59377657
34Dopaminergic synapse_Homo sapiens_hsa047281.57987958
35Caffeine metabolism_Homo sapiens_hsa002321.56052000
36Long-term potentiation_Homo sapiens_hsa047201.52902694
37Renin secretion_Homo sapiens_hsa049241.51681269
38Parkinsons disease_Homo sapiens_hsa050121.46097971
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45540544
40Vibrio cholerae infection_Homo sapiens_hsa051101.43060903
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41455976
42Cocaine addiction_Homo sapiens_hsa050301.36291747
43Olfactory transduction_Homo sapiens_hsa047401.33159500
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31311733
45Pyruvate metabolism_Homo sapiens_hsa006201.31229732
46Folate biosynthesis_Homo sapiens_hsa007901.30576690
47Butanoate metabolism_Homo sapiens_hsa006501.26632558
48RNA degradation_Homo sapiens_hsa030181.26214095
49Cholinergic synapse_Homo sapiens_hsa047251.26032977
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25873705
51Propanoate metabolism_Homo sapiens_hsa006401.25114207
52Alzheimers disease_Homo sapiens_hsa050101.24658418
53Cardiac muscle contraction_Homo sapiens_hsa042601.22139677
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21875203
55Gap junction_Homo sapiens_hsa045401.20502426
56Peroxisome_Homo sapiens_hsa041461.17344658
57Long-term depression_Homo sapiens_hsa047301.16125324
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13373926
59Calcium signaling pathway_Homo sapiens_hsa040201.12146569
60ABC transporters_Homo sapiens_hsa020101.11994996
61Chemical carcinogenesis_Homo sapiens_hsa052041.09475253
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09123774
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05963531
64Sulfur metabolism_Homo sapiens_hsa009201.05007050
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.04479986
66Gastric acid secretion_Homo sapiens_hsa049711.03941167
67Taste transduction_Homo sapiens_hsa047421.01573404
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99931093
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.99677866
70Axon guidance_Homo sapiens_hsa043600.99505965
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98884872
72Retinol metabolism_Homo sapiens_hsa008300.98286525
73One carbon pool by folate_Homo sapiens_hsa006700.97754566
74beta-Alanine metabolism_Homo sapiens_hsa004100.97720859
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96370168
76Oxytocin signaling pathway_Homo sapiens_hsa049210.94909283
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93842408
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.93292507
79Arachidonic acid metabolism_Homo sapiens_hsa005900.92130868
80GnRH signaling pathway_Homo sapiens_hsa049120.87877132
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86984360
82Fatty acid metabolism_Homo sapiens_hsa012120.86536372
83Histidine metabolism_Homo sapiens_hsa003400.83445043
84Purine metabolism_Homo sapiens_hsa002300.80823536
85cAMP signaling pathway_Homo sapiens_hsa040240.79998589
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79709366
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79060836
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77738334
89Dilated cardiomyopathy_Homo sapiens_hsa054140.77186873
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74954628
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74733438
92Ovarian steroidogenesis_Homo sapiens_hsa049130.73507990
93Phototransduction_Homo sapiens_hsa047440.72069541
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71757755
95Glycerolipid metabolism_Homo sapiens_hsa005610.70829649
96Melanogenesis_Homo sapiens_hsa049160.69764854
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68971286
98Asthma_Homo sapiens_hsa053100.68783895
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66955230
100Metabolic pathways_Homo sapiens_hsa011000.66109494
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65938897
102Bile secretion_Homo sapiens_hsa049760.64584955
103Proteasome_Homo sapiens_hsa030500.63302902
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62449922
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.62223497
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61456800
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61300820
108Fatty acid degradation_Homo sapiens_hsa000710.60913016
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60603512
110Regulation of autophagy_Homo sapiens_hsa041400.60034458
111Non-homologous end-joining_Homo sapiens_hsa034500.59643384
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59579196
113Pancreatic secretion_Homo sapiens_hsa049720.59284977
114Fat digestion and absorption_Homo sapiens_hsa049750.58807173
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58549073
116Huntingtons disease_Homo sapiens_hsa050160.58513412
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58401827
118Ether lipid metabolism_Homo sapiens_hsa005650.58156575
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56546443
120Carbon metabolism_Homo sapiens_hsa012000.53746124
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.53050251
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52507934
123Thyroid hormone synthesis_Homo sapiens_hsa049180.51616818
124Prion diseases_Homo sapiens_hsa050200.51348937
125Nucleotide excision repair_Homo sapiens_hsa034200.50790292
126Glioma_Homo sapiens_hsa052140.50652952
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.50621958
128Estrogen signaling pathway_Homo sapiens_hsa049150.49441635
129Pyrimidine metabolism_Homo sapiens_hsa002400.49363047
130Glucagon signaling pathway_Homo sapiens_hsa049220.48912068
131Circadian rhythm_Homo sapiens_hsa047100.48830075
132Sphingolipid metabolism_Homo sapiens_hsa006000.48760742
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47612531
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47035099
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45910481
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.43309422
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43179408
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.43109102
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42775934
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42278271
141Ras signaling pathway_Homo sapiens_hsa040140.40646582
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39758156
143ErbB signaling pathway_Homo sapiens_hsa040120.39329736
144Arginine and proline metabolism_Homo sapiens_hsa003300.38053474
145Galactose metabolism_Homo sapiens_hsa000520.37881184
146Rheumatoid arthritis_Homo sapiens_hsa053230.37755772
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37508349
148Primary immunodeficiency_Homo sapiens_hsa053400.37067177
149Phagosome_Homo sapiens_hsa041450.36328616
150Mineral absorption_Homo sapiens_hsa049780.30911261

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