ISM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)5.15516771
2regulation of gonadotropin secretion (GO:0032276)4.94741276
3keratan sulfate catabolic process (GO:0042340)4.78846528
4surfactant homeostasis (GO:0043129)4.64322613
5thyroid hormone metabolic process (GO:0042403)4.20272151
6epithelial cell-cell adhesion (GO:0090136)4.11301242
7lymph vessel development (GO:0001945)4.10159527
8chemical homeostasis within a tissue (GO:0048875)3.98227917
9axon extension involved in axon guidance (GO:0048846)3.84758555
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.84758555
11lymphangiogenesis (GO:0001946)3.70714367
12vascular endothelial growth factor signaling pathway (GO:0038084)3.68773097
13skin morphogenesis (GO:0043589)3.52808127
14endocardial cushion morphogenesis (GO:0003203)3.48792383
15endocrine hormone secretion (GO:0060986)3.45153771
16regulation of axon extension involved in axon guidance (GO:0048841)3.44462260
17blood vessel maturation (GO:0001955)3.38010134
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.37837777
19collagen fibril organization (GO:0030199)3.36424290
20hemidesmosome assembly (GO:0031581)3.34976162
21molting cycle (GO:0042303)3.32524723
22hair cycle (GO:0042633)3.32524723
23negative regulation of fatty acid transport (GO:2000192)3.25467377
24artery development (GO:0060840)3.21456185
25positive regulation of osteoblast proliferation (GO:0033690)3.16441874
26cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.16303307
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.15705094
28sequestering of extracellular ligand from receptor (GO:0035581)3.15037208
29endocardial cushion development (GO:0003197)3.14404781
30cell adhesion mediated by integrin (GO:0033627)3.10016976
31cell migration involved in sprouting angiogenesis (GO:0002042)3.09378671
32endothelium development (GO:0003158)3.08587269
33regulation of endothelial cell differentiation (GO:0045601)3.08388018
34cellular response to gonadotropin stimulus (GO:0071371)3.03832259
35regulation of axon guidance (GO:1902667)3.01956805
36mesenchyme morphogenesis (GO:0072132)3.01767258
37smooth muscle tissue development (GO:0048745)3.01377144
38toxin metabolic process (GO:0009404)2.99762832
39embryonic eye morphogenesis (GO:0048048)2.96275356
40induction of positive chemotaxis (GO:0050930)2.95367027
41blood vessel remodeling (GO:0001974)2.95199576
42replacement ossification (GO:0036075)2.95100609
43endochondral ossification (GO:0001958)2.95100609
44Notch signaling involved in heart development (GO:0061314)2.95013656
45regulation of water loss via skin (GO:0033561)2.94700136
46bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93720100
47outer ear morphogenesis (GO:0042473)2.93619920
48lung vasculature development (GO:0060426)2.92164950
49angiogenesis involved in wound healing (GO:0060055)2.91479499
50retina vasculature morphogenesis in camera-type eye (GO:0061299)2.91088043
51vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88474135
52keratinocyte proliferation (GO:0043616)2.86275518
53extracellular matrix assembly (GO:0085029)2.85986277
54endothelial cell morphogenesis (GO:0001886)2.85861068
55protein heterotrimerization (GO:0070208)2.85397570
56regulation of vasculogenesis (GO:2001212)2.83482457
57cell-substrate junction assembly (GO:0007044)2.78711202
58insulin-like growth factor receptor signaling pathway (GO:0048009)2.78419441
59chondrocyte development (GO:0002063)2.78339147
60positive regulation of endothelial cell differentiation (GO:0045603)2.78265444
61establishment of skin barrier (GO:0061436)2.78145995
62regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77369989
63low-density lipoprotein particle clearance (GO:0034383)2.77081762
64negative regulation of BMP signaling pathway (GO:0030514)2.75641477
65negative regulation of axon extension involved in axon guidance (GO:0048843)2.72952627
66metanephric nephron epithelium development (GO:0072243)2.72821779
67renal filtration (GO:0097205)2.71596836
68chondrocyte proliferation (GO:0035988)2.69594771
69positive regulation of odontogenesis (GO:0042482)2.67878999
70negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.67182156
71endothelial tube morphogenesis (GO:0061154)2.66846341
72morphogenesis of an endothelium (GO:0003159)2.66846341
73response to parathyroid hormone (GO:0071107)2.66455896
74atrioventricular valve morphogenesis (GO:0003181)2.65800494
75regulation of heart morphogenesis (GO:2000826)2.65766612
76regulation of transforming growth factor beta2 production (GO:0032909)2.64909362
77metanephric mesenchyme development (GO:0072075)2.63699405
78desmosome organization (GO:0002934)2.62267874
79mesodermal cell differentiation (GO:0048333)2.62133153
80regulation of p38MAPK cascade (GO:1900744)2.61319304
81response to gonadotropin (GO:0034698)2.59466430
82cell migration involved in heart development (GO:0060973)2.59394513
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58123763
84collagen metabolic process (GO:0032963)2.57566060
85basement membrane organization (GO:0071711)2.57309678
86adhesion of symbiont to host (GO:0044406)2.56738412
87endothelial cell differentiation (GO:0045446)2.55436811
88multicellular organismal macromolecule metabolic process (GO:0044259)2.54072528
89negative regulation of adherens junction organization (GO:1903392)2.53483311
90negative regulation of focal adhesion assembly (GO:0051895)2.53483311
91negative regulation of cell junction assembly (GO:1901889)2.53483311
92collagen catabolic process (GO:0030574)2.52730799
93positive regulation of cartilage development (GO:0061036)2.52504030
94negative regulation of catenin import into nucleus (GO:0035414)2.50998491
95thyroid gland development (GO:0030878)2.49999181
96embryonic camera-type eye morphogenesis (GO:0048596)2.49198773
97metanephric epithelium development (GO:0072207)2.48407327
98bone trabecula formation (GO:0060346)2.47901683
99substrate-dependent cell migration (GO:0006929)2.47294594
100fibril organization (GO:0097435)2.47274644
101positive regulation of p38MAPK cascade (GO:1900745)2.47111173
102blood vessel endothelial cell migration (GO:0043534)2.46999439
103lung lobe morphogenesis (GO:0060463)2.46419662
104biomineral tissue development (GO:0031214)2.46379658
105negative regulation of chondrocyte differentiation (GO:0032331)2.46238685
106neuron remodeling (GO:0016322)2.45213904
107embryonic foregut morphogenesis (GO:0048617)2.45062860
108G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.44571380
109kidney mesenchyme development (GO:0072074)2.44273203
110regulation of transforming growth factor beta1 production (GO:0032908)2.44225913
111keratinization (GO:0031424)2.44179645
112regulation of cardioblast differentiation (GO:0051890)2.43547471
113glomerular filtration (GO:0003094)2.42760718
114protein localization to endosome (GO:0036010)2.42172637
115positive regulation of collagen biosynthetic process (GO:0032967)2.41988267
116vasculature development (GO:0001944)2.41277600
117patterning of blood vessels (GO:0001569)2.40779807
118stress fiber assembly (GO:0043149)2.40727551
119Leydig cell differentiation (GO:0033327)2.40652571
120multicellular organismal catabolic process (GO:0044243)2.40246443
121heart valve morphogenesis (GO:0003179)2.39929074
122polarized epithelial cell differentiation (GO:0030859)2.39741284
123extracellular fibril organization (GO:0043206)2.39726927
124endodermal cell differentiation (GO:0035987)2.39566078
125sodium ion homeostasis (GO:0055078)2.39051209
126hippo signaling (GO:0035329)2.38618955
127metanephric nephron tubule development (GO:0072234)2.38438443
128metanephric tubule development (GO:0072170)2.38438443
129regulation of secondary heart field cardioblast proliferation (GO:0003266)2.38124684
130regulation of cardioblast proliferation (GO:0003264)2.38124684
131aorta morphogenesis (GO:0035909)2.37039224
132positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.36963194
133hair follicle morphogenesis (GO:0031069)2.36620430
134positive regulation of epidermal cell differentiation (GO:0045606)2.36604834
135multicellular organismal water homeostasis (GO:0050891)2.36409896
136cardiac muscle cell proliferation (GO:0060038)2.36335149
137respiratory tube development (GO:0030323)2.36299025
138multicellular organismal metabolic process (GO:0044236)2.36271837
139response to follicle-stimulating hormone (GO:0032354)2.35723624
140positive regulation of mesenchymal cell proliferation (GO:0002053)2.35632030
141regulation of glomerular filtration (GO:0003093)2.35466773
142endothelial cell proliferation (GO:0001935)2.34666195
143endothelial cell chemotaxis (GO:0035767)2.34590590
144regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.33927487
145dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.32623639
146negative regulation of embryonic development (GO:0045992)2.32542978
147plasma membrane repair (GO:0001778)2.32068398
148mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.31444622
149virion attachment to host cell (GO:0019062)2.29800226
150adhesion of symbiont to host cell (GO:0044650)2.29800226
151protein localization to cell surface (GO:0034394)2.29721168
152wound healing, spreading of epidermal cells (GO:0035313)2.26449638
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26270676
154negative regulation of cell-matrix adhesion (GO:0001953)2.24984230
155coronary vasculature morphogenesis (GO:0060977)2.23648823
156extracellular matrix disassembly (GO:0022617)2.23058972
157pattern specification involved in kidney development (GO:0061004)2.22219986
158regulation of mesenchymal cell proliferation (GO:0010464)2.22093740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.31664278
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.41964364
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.88820916
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78699901
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.63907447
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63354031
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63354031
8EZH2_22144423_ChIP-Seq_EOC_Human2.60769851
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58274548
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52877383
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48904516
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42070210
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36209390
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20011257
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.11476711
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08411661
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08273757
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07297101
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03832314
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.00027591
21GBX2_23144817_ChIP-Seq_PC3_Human1.99573606
22* EZH2_27304074_Chip-Seq_ESCs_Mouse1.96565918
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93387650
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93210901
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92690939
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90636579
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83817089
28CLOCK_20551151_ChIP-Seq_293T_Human1.82202656
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.81225709
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79163791
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77815311
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.77553748
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71644525
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71258319
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71004822
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69936413
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.64685315
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64449638
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63759427
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62508123
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.61896909
42TP53_18474530_ChIP-ChIP_U2OS_Human1.59788010
43AHR_22903824_ChIP-Seq_MCF-7_Human1.59236106
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59134601
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57788464
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57339500
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.54534668
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50796561
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50353328
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.49267166
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.47733110
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47024405
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.45338338
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45027779
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.44995971
56ZNF263_19887448_ChIP-Seq_K562_Human1.44900997
57CJUN_26792858_Chip-Seq_BT549_Human1.44892336
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43567876
59AR_21572438_ChIP-Seq_LNCaP_Human1.43457409
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43138603
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43138603
62RACK7_27058665_Chip-Seq_MCF-7_Human1.42026970
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.42008039
64* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38878542
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.36837539
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.36570795
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.35474907
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35246277
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34938767
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34718246
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34307054
72DROSHA_22980978_ChIP-Seq_HELA_Human1.34159073
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31703125
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31699264
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28624780
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.28622173
77LXR_22292898_ChIP-Seq_THP-1_Human1.27719559
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26691134
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25845856
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24577657
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23474007
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22368785
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22187646
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22147262
85TP53_16413492_ChIP-PET_HCT116_Human1.21116446
86* ISL1_27105846_Chip-Seq_CPCs_Mouse1.19836039
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.19272044
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19028439
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18975949
90SOX2_20726797_ChIP-Seq_SW620_Human1.18845446
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18781193
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18301592
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15898646
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14833901
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14655141
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13833904
97* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13424360
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13360449
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.13339074
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11756808
101BCAT_22108803_ChIP-Seq_LS180_Human1.10625888
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09954302
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.08362213
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08231659
105SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07853253
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.06158699
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03917742
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03155434
109SA1_22415368_ChIP-Seq_MEFs_Mouse1.03136669
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01892805
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.01585671
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01059667
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.00329704
114RXR_22108803_ChIP-Seq_LS180_Human0.99090469
115KDM2B_26808549_Chip-Seq_K562_Human0.99061592
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98778080
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96920609
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96224656
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.95671027
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.95253859
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95111779
122SMAD4_21799915_ChIP-Seq_A2780_Human0.94720456
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93753363
124* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93486874
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93356655
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93273128
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92545811
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92111819
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91527072
130BRD4_25478319_ChIP-Seq_HGPS_Human0.91220161
131* KLF5_25053715_ChIP-Seq_YYC3_Human0.90373281
132TCF7_22412390_ChIP-Seq_EML_Mouse0.90152613
133ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89202160
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86000851
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85983763
136* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85676871
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.84813571
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.84813571
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84693458
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84693458
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.84533734
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84076635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.23027143
2MP0005275_abnormal_skin_tensile4.01919621
3MP0001958_emphysema3.68881922
4MP0005503_abnormal_tendon_morphology3.67184158
5MP0004272_abnormal_basement_membrane3.49661193
6MP0010368_abnormal_lymphatic_system3.41731036
7MP0001879_abnormal_lymphatic_vessel3.09736471
8MP0003283_abnormal_digestive_organ2.97491664
9MP0003705_abnormal_hypodermis_morpholog2.88478747
10MP0005409_darkened_coat_color2.64311346
11MP0010234_abnormal_vibrissa_follicle2.38786736
12MP0003279_aneurysm2.17661428
13MP0005623_abnormal_meninges_morphology2.17088791
14MP0009250_abnormal_appendicular_skeleto2.12620589
15MP0000537_abnormal_urethra_morphology2.04214148
16MP0002295_abnormal_pulmonary_circulatio1.96377545
17MP0009384_cardiac_valve_regurgitation1.95417496
18MP0000534_abnormal_ureter_morphology1.93253644
19MP0005076_abnormal_cell_differentiation1.83020507
20MP0010678_abnormal_skin_adnexa1.82492596
21MP0005508_abnormal_skeleton_morphology1.80610562
22MP0000383_abnormal_hair_follicle1.79259273
23MP0003941_abnormal_skin_development1.76139830
24MP0003566_abnormal_cell_adhesion1.74119935
25MP0000681_abnormal_thyroid_gland1.64714096
26MP0005167_abnormal_blood-brain_barrier1.62981606
27MP0002876_abnormal_thyroid_physiology1.60042171
28MP0004381_abnormal_hair_follicle1.55387720
29MP0009053_abnormal_anal_canal1.53003909
30MP0006054_spinal_hemorrhage1.52891965
31MP0003942_abnormal_urinary_system1.48422689
32MP0002998_abnormal_bone_remodeling1.47319106
33MP0000767_abnormal_smooth_muscle1.47007217
34MP0003453_abnormal_keratinocyte_physiol1.46884167
35MP0000003_abnormal_adipose_tissue1.45900672
36MP0003091_abnormal_cell_migration1.43655447
37MP0002060_abnormal_skin_morphology1.40878956
38MP0002877_abnormal_melanocyte_morpholog1.37465939
39MP0004859_abnormal_synaptic_plasticity1.32785309
40MP0001177_atelectasis1.32499982
41MP0003115_abnormal_respiratory_system1.29596967
42MP0001851_eye_inflammation1.28618606
43MP0005501_abnormal_skin_physiology1.28510905
44MP0002933_joint_inflammation1.28010671
45MP0002282_abnormal_trachea_morphology1.27937656
46MP0001188_hyperpigmentation1.25726626
47MP0003385_abnormal_body_wall1.25661867
48MP0000762_abnormal_tongue_morphology1.25660041
49MP0000516_abnormal_urinary_system1.24812745
50MP0005367_renal/urinary_system_phenotyp1.24812745
51MP0009379_abnormal_foot_pigmentation1.23969643
52MP0001299_abnormal_eye_distance/1.23179431
53MP0002133_abnormal_respiratory_system1.21302166
54MP0005388_respiratory_system_phenotype1.21302166
55MP0005375_adipose_tissue_phenotype1.19934232
56MP0002249_abnormal_larynx_morphology1.19291689
57MP0004782_abnormal_surfactant_physiolog1.18403046
58MP0005257_abnormal_intraocular_pressure1.18399930
59MP0000678_abnormal_parathyroid_gland1.16899848
60MP0009780_abnormal_chondrocyte_physiolo1.16739254
61MP0005595_abnormal_vascular_smooth1.15813594
62MP0002108_abnormal_muscle_morphology1.14790266
63MP0000013_abnormal_adipose_tissue1.13600313
64MP0005670_abnormal_white_adipose1.12413769
65MP0002896_abnormal_bone_mineralization1.11960471
66MP0005408_hypopigmentation1.08960889
67MP0001849_ear_inflammation1.06719890
68MP0004858_abnormal_nervous_system1.06378663
69MP0002089_abnormal_postnatal_growth/wei1.05345309
70MP0005023_abnormal_wound_healing1.04210004
71MP0005164_abnormal_response_to1.03411831
72MP0002796_impaired_skin_barrier1.02326428
73MP0005666_abnormal_adipose_tissue1.02008270
74MP0006138_congestive_heart_failure1.01529598
75MP0000579_abnormal_nail_morphology0.99066836
76MP0004883_abnormal_blood_vessel0.98957032
77MP0002115_abnormal_skeleton_extremities0.98543908
78MP0004484_altered_response_of0.98056521
79MP0010771_integument_phenotype0.97343350
80MP0003795_abnormal_bone_structure0.96833202
81MP0003191_abnormal_cellular_cholesterol0.95482024
82MP0000751_myopathy0.95440655
83MP0000377_abnormal_hair_follicle0.95182685
84MP0000163_abnormal_cartilage_morphology0.95055732
85MP0003937_abnormal_limbs/digits/tail_de0.92387391
86MP0003868_abnormal_feces_composition0.90954010
87MP0002925_abnormal_cardiovascular_devel0.90636769
88MP0004084_abnormal_cardiac_muscle0.89617034
89MP0003935_abnormal_craniofacial_develop0.89430846
90MP0000049_abnormal_middle_ear0.88760618
91MP0001216_abnormal_epidermal_layer0.86975987
92MP0003828_pulmonary_edema0.86875468
93MP0001346_abnormal_lacrimal_gland0.84413630
94MP0004233_abnormal_muscle_weight0.83396185
95MP0001270_distended_abdomen0.82757525
96MP0003755_abnormal_palate_morphology0.81367176
97MP0002234_abnormal_pharynx_morphology0.81188462
98MP0001661_extended_life_span0.80921766
99MP0010352_gastrointestinal_tract_polyps0.79685300
100MP0003195_calcinosis0.79430744
101MP0002128_abnormal_blood_circulation0.79349134
102MP0002233_abnormal_nose_morphology0.79215803
103MP0003045_fibrosis0.78824955
104MP0001175_abnormal_lung_morphology0.78198462
105MP0003635_abnormal_synaptic_transmissio0.77968575
106MP0000432_abnormal_head_morphology0.77700537
107MP0004885_abnormal_endolymph0.77534731
108MP0000467_abnormal_esophagus_morphology0.77473287
109MP0002168_other_aberrant_phenotype0.77428528
110MP0005171_absent_coat_pigmentation0.77252409
111MP0004185_abnormal_adipocyte_glucose0.75478196
112MP0001614_abnormal_blood_vessel0.74364821
113MP0005248_abnormal_Harderian_gland0.74172831
114MP0002098_abnormal_vibrissa_morphology0.73801481
115MP0000462_abnormal_digestive_system0.72779628
116MP0005390_skeleton_phenotype0.71084024
117MP0003122_maternal_imprinting0.70961405
118MP0005165_increased_susceptibility_to0.70877122
119MP0005083_abnormal_biliary_tract0.70158794
120MP0001533_abnormal_skeleton_physiology0.69294058
121MP0010329_abnormal_lipoprotein_level0.68990299
122MP0001340_abnormal_eyelid_morphology0.68832508
123MP0002932_abnormal_joint_morphology0.68574479
124MP0001542_abnormal_bone_strength0.68337947
125MP0009931_abnormal_skin_appearance0.68224084
126MP0002109_abnormal_limb_morphology0.68151658
127MP0003011_delayed_dark_adaptation0.67962541
128MP0000627_abnormal_mammary_gland0.67858741
129MP0005187_abnormal_penis_morphology0.67417707
130MP0000733_abnormal_muscle_development0.67327967
131MP0000428_abnormal_craniofacial_morphol0.66377256
132MP0003880_abnormal_central_pattern0.65429719
133MP0003300_gastrointestinal_ulcer0.65268016
134MP0001968_abnormal_touch/_nociception0.65211259
135MP0010030_abnormal_orbit_morphology0.65141394
136MP0004085_abnormal_heartbeat0.64770195
137MP0002113_abnormal_skeleton_development0.64016489
138MP0000566_synostosis0.63740226
139MP0001243_abnormal_dermal_layer0.62818241

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.97925320
2Protrusio acetabuli (HP:0003179)4.67313652
3Papilledema (HP:0001085)4.00046852
4Aortic dissection (HP:0002647)3.97081566
5Atrophic scars (HP:0001075)3.96949262
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.93683068
7Shallow orbits (HP:0000586)3.92111000
8Small epiphyses (HP:0010585)3.87990299
9Broad metatarsal (HP:0001783)3.79438367
10Aortic aneurysm (HP:0004942)3.73593539
11Vascular tortuosity (HP:0004948)3.62208935
12Mild short stature (HP:0003502)3.40940141
13Cerebral aneurysm (HP:0004944)3.19781172
14Hyperactive renin-angiotensin system (HP:0000841)3.17857951
15Arterial tortuosity (HP:0005116)3.17530782
16Coxa vara (HP:0002812)3.14494077
17Hypophosphatemic rickets (HP:0004912)3.12518431
18Hematochezia (HP:0002573)3.09852625
19Pili torti (HP:0003777)3.09358533
20Cupped ribs (HP:0000887)3.04744370
21Ankle contracture (HP:0006466)3.04041253
22Bladder diverticulum (HP:0000015)3.02138074
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.95977144
24Osteolytic defects of the hand bones (HP:0009699)2.95977144
25Onycholysis (HP:0001806)2.83590230
26Camptodactyly of toe (HP:0001836)2.79414254
27Fragile skin (HP:0001030)2.78725344
28Long toe (HP:0010511)2.76582914
29Spondylolisthesis (HP:0003302)2.68838600
30Metaphyseal cupping (HP:0003021)2.68091249
31Mitral valve prolapse (HP:0001634)2.63511571
32Flared iliac wings (HP:0002869)2.63361475
33Soft skin (HP:0000977)2.61719312
34Abnormality of the phalanges of the hallux (HP:0010057)2.60691947
35Thyroid-stimulating hormone excess (HP:0002925)2.56690839
36Dilatation of the ascending aorta (HP:0005111)2.55458662
37Buphthalmos (HP:0000557)2.54678280
38Bronchomalacia (HP:0002780)2.50249366
39Abnormality of dentin (HP:0010299)2.49956315
40Craniofacial hyperostosis (HP:0004493)2.47247774
41Absent frontal sinuses (HP:0002688)2.46897899
42Follicular hyperkeratosis (HP:0007502)2.46106501
43Spinal cord compression (HP:0002176)2.45759019
44Genu varum (HP:0002970)2.44276993
45Interstitial pulmonary disease (HP:0006530)2.43458920
46Abnormality of carpal bone ossification (HP:0006257)2.42252263
47Bell-shaped thorax (HP:0001591)2.41397525
48Hyperextensible skin (HP:0000974)2.40384660
49Wrist flexion contracture (HP:0001239)2.40225669
50Peritonitis (HP:0002586)2.38845043
51Spinal rigidity (HP:0003306)2.37329850
52Metaphyseal dysplasia (HP:0100255)2.36582607
53Type 1 muscle fiber predominance (HP:0003803)2.36329372
54Midline defect of the nose (HP:0004122)2.36029970
55Round ear (HP:0100830)2.35133292
56Goiter (HP:0000853)2.34340400
57Tibial bowing (HP:0002982)2.33805091
58Pulmonary artery stenosis (HP:0004415)2.32465332
59Alopecia of scalp (HP:0002293)2.30091665
60Polycythemia (HP:0001901)2.27019379
61Wormian bones (HP:0002645)2.26971503
62Neonatal short-limb short stature (HP:0008921)2.26424942
63Femoral bowing (HP:0002980)2.25126302
64Vertebral compression fractures (HP:0002953)2.24791202
65Shawl scrotum (HP:0000049)2.24500139
66Venous insufficiency (HP:0005293)2.23111067
67Abnormal hair laboratory examination (HP:0003328)2.23041755
68Back pain (HP:0003418)2.20821366
69Aplasia involving bones of the upper limbs (HP:0009823)2.20506583
70Aplasia of the phalanges of the hand (HP:0009802)2.20506583
71Aplasia involving bones of the extremities (HP:0009825)2.20506583
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.17142631
73Potter facies (HP:0002009)2.17045866
74Facial shape deformation (HP:0011334)2.17045866
75Mildly elevated creatine phosphokinase (HP:0008180)2.16958910
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.16812980
77Ridged nail (HP:0001807)2.16064492
78Overgrowth (HP:0001548)2.14582369
79Increased variability in muscle fiber diameter (HP:0003557)2.14575180
80Persistence of primary teeth (HP:0006335)2.14073476
81Mitral stenosis (HP:0001718)2.13913185
82Aneurysm (HP:0002617)2.12678965
83Cranial hyperostosis (HP:0004437)2.11249355
84Deviation of the hallux (HP:0010051)2.09771682
85Cervical subluxation (HP:0003308)2.09709833
86Short hallux (HP:0010109)2.09233626
87Fragile nails (HP:0001808)2.07638402
88Venous abnormality (HP:0002624)2.07214830
89Abnormality of complement system (HP:0005339)2.07125244
90Woolly hair (HP:0002224)2.05904500
91Abnormal ossification of hand bones (HP:0005921)2.05699859
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04706431
93Bowel diverticulosis (HP:0005222)2.04664982
94Ovoid vertebral bodies (HP:0003300)2.04308040
95Genu recurvatum (HP:0002816)2.04262074
96Ulnar bowing (HP:0003031)2.00830128
97Abnormality of the pulmonary veins (HP:0011718)2.00574639
98Hallux valgus (HP:0001822)2.00498027
99Abnormality of calcium-phosphate metabolism (HP:0100530)1.98871456
100Abnormality of the acetabulum (HP:0003170)1.98782512
101Milia (HP:0001056)1.96943442
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94727725
103Increased connective tissue (HP:0009025)1.94699638
104Flexion contracture of toe (HP:0005830)1.94628316
105Joint contractures involving the joints of the feet (HP:0100492)1.94628316
106Absent hand (HP:0004050)1.93017331
107Broad ribs (HP:0000885)1.92959302
108Complement deficiency (HP:0004431)1.92167343
109Abnormality of femoral epiphyses (HP:0006499)1.91854468
110Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.91854468
111Obstructive sleep apnea (HP:0002870)1.91496194
112Vertebral arch anomaly (HP:0008438)1.90684967
113Osteoarthritis (HP:0002758)1.90519813
114Slender build (HP:0001533)1.90411740
115Partial duplication of the phalanx of hand (HP:0009999)1.89997401
116Elbow flexion contracture (HP:0002987)1.88140529
117Abnormal hand bone ossification (HP:0010660)1.87869798
118Blue sclerae (HP:0000592)1.87339457
119Abnormality of the vertebral endplates (HP:0005106)1.86020495
120Abnormality of nail color (HP:0100643)1.85379398
121Deep venous thrombosis (HP:0002625)1.84716398
122Thickened helices (HP:0000391)1.84675423
123Hydroureter (HP:0000072)1.84650670
124Hypoplastic left heart (HP:0004383)1.84558319
125Gonadotropin excess (HP:0000837)1.84253001
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.84188347
127Absent eyelashes (HP:0000561)1.83179046
128Short middle phalanx of finger (HP:0005819)1.83055538
129Hyperkalemia (HP:0002153)1.82447887
130Right ventricular cardiomyopathy (HP:0011663)1.82375253
131Choanal stenosis (HP:0000452)1.82345327
132Coronal craniosynostosis (HP:0004440)1.82246259
133Striae distensae (HP:0001065)1.79502666
134Broad palm (HP:0001169)1.79381209
135Abnormality of skeletal muscle fiber size (HP:0012084)1.79356481
136Mitral regurgitation (HP:0001653)1.77858609
137Abnormality of the middle phalanges of the toes (HP:0010183)1.77348205
138Lymphangioma (HP:0100764)1.77135363
139Epiphyseal dysplasia (HP:0002656)1.76702439
140Rickets (HP:0002748)1.76274790
141Joint laxity (HP:0001388)1.76182391
142Disproportionate tall stature (HP:0001519)1.76101498
143Decreased circulating renin level (HP:0003351)1.75401440
144Joint stiffness (HP:0001387)1.72838001
145Osteomalacia (HP:0002749)1.72062620
146Abnormality of the proximal phalanges of the hand (HP:0009834)1.71358463
147Cerebral inclusion bodies (HP:0100314)1.71065424
148Abnormal umbilical cord blood vessels (HP:0011403)1.70660670
149Single umbilical artery (HP:0001195)1.70660670
150Abnormality of the fetal cardiovascular system (HP:0010948)1.70660670
151Mixed hearing impairment (HP:0000410)1.69884767
152Asymmetry of the thorax (HP:0001555)1.69078591
153Congenital glaucoma (HP:0001087)1.67903492
154Hypoventilation (HP:0002791)1.66729348
155Hypotrichosis (HP:0001006)1.66582797
156Abnormality of the 2nd finger (HP:0004100)1.65663127
157Hypoplasia of the iris (HP:0007676)1.65246147
158Bowing of the arm (HP:0006488)1.64939797
159Bowed forearm bones (HP:0003956)1.64939797
160Visceral angiomatosis (HP:0100761)1.64676147
161Renal salt wasting (HP:0000127)1.64249631
162Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.63875158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.17853436
2TIE13.38191535
3EPHB23.35066225
4FER2.70598216
5MAPK152.65207855
6PDGFRA2.57561430
7EEF2K2.55975196
8PRPF4B2.32843437
9LATS22.28841624
10FGFR22.28691972
11CDK122.27306433
12AKT32.24395949
13MYLK2.19691275
14MAP3K62.18518251
15EPHA22.16158803
16LATS12.15852652
17PTK2B2.12980512
18ICK2.12522525
19TGFBR22.04869289
20EPHA42.04852174
21TRIB31.95554337
22RIPK11.93264329
23DAPK21.86649228
24KSR21.84990468
25TTN1.73908467
26NTRK11.71347536
27TESK11.71263244
28EPHA31.65421842
29NLK1.64805465
30MAP3K21.63977771
31MAP3K91.62823095
32NTRK31.62296789
33MET1.51726473
34SMG11.36855687
35ERN11.35418633
36LRRK21.34787747
37MST1R1.34726291
38DMPK1.32947644
39PRKD31.32741900
40PAK41.28490743
41RIPK41.20977808
42PTK21.18974188
43RET1.16717640
44PAK31.14611245
45PLK21.14536162
46PDGFRB1.13307073
47GRK51.12599169
48KDR1.10646374
49MAP3K121.08007158
50MAPKAPK31.07419593
51MAPK71.06288950
52MTOR1.06239659
53FRK1.04819288
54FGR1.00550150
55PHKG11.00353332
56PHKG21.00353332
57BCR0.98730723
58CASK0.95348271
59PAK20.95063545
60TGFBR10.93847722
61PTK60.93090843
62MINK10.91453942
63MAP3K30.90765388
64FGFR10.90279602
65MAP3K130.89684698
66MAPK120.89394481
67ROCK20.87658373
68MAP2K10.84327624
69CDK90.80986493
70RPS6KA20.80774698
71ROCK10.79421031
72CDC42BPA0.78902395
73PRKAA20.77880436
74DAPK30.77603570
75EPHB10.76642433
76JAK10.75703530
77FGFR30.75660191
78ILK0.74118833
79SIK10.72634342
80PRKD10.71445719
81BMX0.68959027
82KSR10.67018975
83DAPK10.66700423
84MAP3K70.65906534
85STK390.64940032
86LMTK20.63780023
87PRKCH0.63429393
88BMPR1B0.61163182
89MELK0.60803922
90CAMK1G0.60020503
91PRKCE0.59781046
92GRK10.57760110
93MAPKAPK50.57179621
94TYRO30.57025156
95SRC0.56615260
96ARAF0.56385163
97MOS0.56349172
98CDK70.56090287
99PAK60.55134776
100CDK50.53739238
101PRKD20.52458171
102NEK90.52188324
103PKN20.51649736
104CAMK2A0.50436826
105MAP3K10.49844073
106STK30.48992014
107PIK3CA0.48415326
108CAMK2B0.47761492
109INSR0.47503934
110FYN0.46771038
111ADRBK10.46733458
112STK380.46226562
113MAPKAPK20.45991883
114CAMKK10.45043172
115TAOK20.44784310
116MAPK40.44211076
117ERBB30.44054854
118FGFR40.42712692
119WNK10.42658352
120MST40.42042468
121EGFR0.41692245
122TRPM70.41177293
123STK100.39501007
124IGF1R0.39142661
125STK38L0.38494376
126BRD40.38131237
127CDK80.37927392
128RPS6KC10.37668282
129RPS6KL10.37668282
130MAP2K40.37225144
131PDPK10.36763383
132CDK40.36352278
133MAP3K40.36321470
134CDK60.36177246
135MAPK10.35892072
136NUAK10.34929889
137SIK30.33698757
138MARK20.33053743
139MAPK30.32876001
140CSNK1G20.31994336
141CDK140.31509076
142CDK30.31038444
143ZAP700.30576427
144HIPK20.30432741
145GSK3A0.30336212
146TYK20.29339375

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.61262692
2Complement and coagulation cascades_Homo sapiens_hsa046102.09374640
3Focal adhesion_Homo sapiens_hsa045102.03515213
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.03171629
5Thyroid hormone synthesis_Homo sapiens_hsa049181.79267749
6Phenylalanine metabolism_Homo sapiens_hsa003601.68055994
7Long-term potentiation_Homo sapiens_hsa047201.63656639
8Axon guidance_Homo sapiens_hsa043601.63505678
9Notch signaling pathway_Homo sapiens_hsa043301.63237734
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62294761
11Renin secretion_Homo sapiens_hsa049241.61306037
12Tyrosine metabolism_Homo sapiens_hsa003501.60817118
13Gastric acid secretion_Homo sapiens_hsa049711.60615806
14Salivary secretion_Homo sapiens_hsa049701.58327565
15Amphetamine addiction_Homo sapiens_hsa050311.56861230
16Melanogenesis_Homo sapiens_hsa049161.53574361
17Circadian entrainment_Homo sapiens_hsa047131.51720338
18Adherens junction_Homo sapiens_hsa045201.49063039
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47996810
20Hippo signaling pathway_Homo sapiens_hsa043901.46714132
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.45259761
22Dilated cardiomyopathy_Homo sapiens_hsa054141.44300185
23Proteoglycans in cancer_Homo sapiens_hsa052051.44198167
24TGF-beta signaling pathway_Homo sapiens_hsa043501.41026064
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38996397
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.37758755
27Protein digestion and absorption_Homo sapiens_hsa049741.33391802
28Glioma_Homo sapiens_hsa052141.32654019
29Rap1 signaling pathway_Homo sapiens_hsa040151.32549754
30Amoebiasis_Homo sapiens_hsa051461.31097447
31Circadian rhythm_Homo sapiens_hsa047101.30346970
32Oxytocin signaling pathway_Homo sapiens_hsa049211.30182320
33Estrogen signaling pathway_Homo sapiens_hsa049151.26780360
34GnRH signaling pathway_Homo sapiens_hsa049121.26611353
35Tight junction_Homo sapiens_hsa045301.25860665
36Basal cell carcinoma_Homo sapiens_hsa052171.25715568
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25291780
38Dopaminergic synapse_Homo sapiens_hsa047281.24880433
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24156136
40Bladder cancer_Homo sapiens_hsa052191.23927369
41PPAR signaling pathway_Homo sapiens_hsa033201.23189633
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21995663
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21568317
44Gap junction_Homo sapiens_hsa045401.20246265
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.20018056
46Long-term depression_Homo sapiens_hsa047301.19599260
47VEGF signaling pathway_Homo sapiens_hsa043701.16933794
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15674029
49Histidine metabolism_Homo sapiens_hsa003401.14807592
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14456775
51Nicotine addiction_Homo sapiens_hsa050331.14354176
52Renal cell carcinoma_Homo sapiens_hsa052111.14200790
53Prion diseases_Homo sapiens_hsa050201.13309852
54Cocaine addiction_Homo sapiens_hsa050301.12157065
55Dorso-ventral axis formation_Homo sapiens_hsa043201.06155321
56Cholinergic synapse_Homo sapiens_hsa047251.04965448
57Glutamatergic synapse_Homo sapiens_hsa047241.04256516
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03893715
59Wnt signaling pathway_Homo sapiens_hsa043101.03628728
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03051121
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02173220
62GABAergic synapse_Homo sapiens_hsa047271.02161632
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02095311
64Melanoma_Homo sapiens_hsa052181.00166172
65Acute myeloid leukemia_Homo sapiens_hsa052210.99385659
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97799619
67Vibrio cholerae infection_Homo sapiens_hsa051100.95957414
68Morphine addiction_Homo sapiens_hsa050320.95122148
69Synaptic vesicle cycle_Homo sapiens_hsa047210.95119519
70Ras signaling pathway_Homo sapiens_hsa040140.94225822
71Calcium signaling pathway_Homo sapiens_hsa040200.93933835
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93705878
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93358198
74cAMP signaling pathway_Homo sapiens_hsa040240.92681958
75Taste transduction_Homo sapiens_hsa047420.91864252
76Hedgehog signaling pathway_Homo sapiens_hsa043400.91064825
77Platelet activation_Homo sapiens_hsa046110.88624728
78Olfactory transduction_Homo sapiens_hsa047400.87378937
79Bile secretion_Homo sapiens_hsa049760.86682470
80Pathways in cancer_Homo sapiens_hsa052000.85443740
81Small cell lung cancer_Homo sapiens_hsa052220.84633998
82Serotonergic synapse_Homo sapiens_hsa047260.83208148
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78828395
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78744276
85Insulin secretion_Homo sapiens_hsa049110.78431599
86Autoimmune thyroid disease_Homo sapiens_hsa053200.77230552
87Lysine degradation_Homo sapiens_hsa003100.74776317
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73257791
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72930258
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.72550439
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.72290888
92Glycerolipid metabolism_Homo sapiens_hsa005610.72164867
93Endometrial cancer_Homo sapiens_hsa052130.71838099
94Thyroid cancer_Homo sapiens_hsa052160.71717184
95ErbB signaling pathway_Homo sapiens_hsa040120.70117828
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70001593
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69982921
98AMPK signaling pathway_Homo sapiens_hsa041520.69888580
99Insulin signaling pathway_Homo sapiens_hsa049100.69066043
100Other glycan degradation_Homo sapiens_hsa005110.67484728
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.67149014
102Prostate cancer_Homo sapiens_hsa052150.66440941
103MicroRNAs in cancer_Homo sapiens_hsa052060.66355029
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65840050
105Mineral absorption_Homo sapiens_hsa049780.65684043
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65555231
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64410549
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64265391
109Insulin resistance_Homo sapiens_hsa049310.63564114
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.63541198
111Non-small cell lung cancer_Homo sapiens_hsa052230.63220016
112Ovarian steroidogenesis_Homo sapiens_hsa049130.62929065
113MAPK signaling pathway_Homo sapiens_hsa040100.62783798
114Pancreatic cancer_Homo sapiens_hsa052120.62728881
115Inositol phosphate metabolism_Homo sapiens_hsa005620.61933178
116mTOR signaling pathway_Homo sapiens_hsa041500.61468885
117Collecting duct acid secretion_Homo sapiens_hsa049660.61256336
118Rheumatoid arthritis_Homo sapiens_hsa053230.60572723
119Malaria_Homo sapiens_hsa051440.60346360
120Prolactin signaling pathway_Homo sapiens_hsa049170.60147205
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59741597
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59650738
123Choline metabolism in cancer_Homo sapiens_hsa052310.58521143
124Colorectal cancer_Homo sapiens_hsa052100.58518403
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.58328839
126Chronic myeloid leukemia_Homo sapiens_hsa052200.56956404
127Phagosome_Homo sapiens_hsa041450.56688847
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.56441447
129FoxO signaling pathway_Homo sapiens_hsa040680.56217748
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53587585
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49323137
132Sphingolipid metabolism_Homo sapiens_hsa006000.47641490
133ABC transporters_Homo sapiens_hsa020100.45601406
134Fatty acid degradation_Homo sapiens_hsa000710.44800060
135Lysosome_Homo sapiens_hsa041420.44199783

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