ISLR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.12992261
2collagen fibril organization (GO:0030199)6.18880939
3bone trabecula formation (GO:0060346)6.05839536
4sequestering of extracellular ligand from receptor (GO:0035581)5.03003676
5virion attachment to host cell (GO:0019062)4.94764903
6adhesion of symbiont to host cell (GO:0044650)4.94764903
7extracellular fibril organization (GO:0043206)4.87228087
8keratan sulfate catabolic process (GO:0042340)4.81545624
9regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.59946127
10dermatan sulfate biosynthetic process (GO:0030208)4.58057951
11collagen metabolic process (GO:0032963)4.56403717
12collagen catabolic process (GO:0030574)4.51492547
13cell proliferation involved in metanephros development (GO:0072203)4.46006366
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.38844437
15multicellular organismal macromolecule metabolic process (GO:0044259)4.30733697
16adhesion of symbiont to host (GO:0044406)4.27317465
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.19176472
18chondrocyte proliferation (GO:0035988)4.18205715
19dermatan sulfate metabolic process (GO:0030205)4.17862410
20multicellular organismal catabolic process (GO:0044243)4.16899121
21fibril organization (GO:0097435)4.14795024
22type B pancreatic cell proliferation (GO:0044342)4.10394918
23cell proliferation involved in kidney development (GO:0072111)4.09775412
24mesenchymal-epithelial cell signaling (GO:0060638)4.09566886
25multicellular organismal metabolic process (GO:0044236)4.08538797
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.96478194
27prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.91928839
28negative regulation of chondrocyte differentiation (GO:0032331)3.89282796
29craniofacial suture morphogenesis (GO:0097094)3.87089579
30extracellular matrix assembly (GO:0085029)3.78688902
31tooth mineralization (GO:0034505)3.78116516
32extracellular matrix disassembly (GO:0022617)3.77071179
33regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.76589658
34chondrocyte development (GO:0002063)3.69372984
35cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.66230658
36vascular endothelial growth factor signaling pathway (GO:0038084)3.62435751
37endodermal cell differentiation (GO:0035987)3.59366306
38glomerular basement membrane development (GO:0032836)3.58220693
39lateral sprouting from an epithelium (GO:0060601)3.54260929
40mesenchymal cell proliferation (GO:0010463)3.48016995
41negative regulation of smooth muscle cell migration (GO:0014912)3.47261849
42metanephric mesenchyme development (GO:0072075)3.47249233
43myelination in peripheral nervous system (GO:0022011)3.46818758
44peripheral nervous system axon ensheathment (GO:0032292)3.46818758
45negative regulation of cartilage development (GO:0061037)3.45838811
46embryonic skeletal joint morphogenesis (GO:0060272)3.45751640
47barbed-end actin filament capping (GO:0051016)3.44537049
48negative regulation of catenin import into nucleus (GO:0035414)3.43478809
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39481934
50axon extension involved in axon guidance (GO:0048846)3.39255901
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.39255901
52regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.38739838
53kidney mesenchyme development (GO:0072074)3.36009437
54basement membrane organization (GO:0071711)3.35023559
55branching involved in salivary gland morphogenesis (GO:0060445)3.29617608
56skin morphogenesis (GO:0043589)3.29530481
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.28538024
58gonadal mesoderm development (GO:0007506)3.26799831
59positive regulation of glycogen biosynthetic process (GO:0045725)3.24408121
60endothelial cell morphogenesis (GO:0001886)3.21720919
61Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.21367670
62outer ear morphogenesis (GO:0042473)3.19755990
63positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.16530397
64blood vessel maturation (GO:0001955)3.16220632
65extracellular matrix organization (GO:0030198)3.14531868
66extracellular structure organization (GO:0043062)3.13237884
67regulation of establishment of planar polarity (GO:0090175)3.11803883
68anatomical structure regression (GO:0060033)3.10913169
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.10207027
70regulation of non-canonical Wnt signaling pathway (GO:2000050)3.10082897
71mesenchyme morphogenesis (GO:0072132)3.08939880
72glial cell migration (GO:0008347)3.08132656
73trabecula formation (GO:0060343)3.08001830
74glomerular filtration (GO:0003094)3.06815815
75branching involved in prostate gland morphogenesis (GO:0060442)3.06243501
76organ induction (GO:0001759)3.03740165
77positive regulation of cartilage development (GO:0061036)3.00622484
78regulation of chondrocyte differentiation (GO:0032330)2.99436752
79negative regulation of leukocyte chemotaxis (GO:0002689)2.99054739
80non-canonical Wnt signaling pathway (GO:0035567)2.97358905
81regulation of cartilage development (GO:0061035)2.96652307
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.92716286
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.90930045
84smooth muscle tissue development (GO:0048745)2.90602485
85convergent extension (GO:0060026)2.89484521
86embryonic cranial skeleton morphogenesis (GO:0048701)2.88275799
87regulation of extracellular matrix disassembly (GO:0010715)2.85716318
88regulation of plasminogen activation (GO:0010755)2.85431200
89cell migration involved in heart development (GO:0060973)2.85396047
90chondroitin sulfate catabolic process (GO:0030207)2.84977879
91regulation of integrin-mediated signaling pathway (GO:2001044)2.84443737
92negative regulation of heart growth (GO:0061117)2.80310334
93negative regulation of cardiac muscle tissue growth (GO:0055022)2.80310334
94retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79287808
95protein retention in ER lumen (GO:0006621)2.78382012
96middle ear morphogenesis (GO:0042474)2.78378824
97positive regulation of endothelial cell apoptotic process (GO:2000353)2.78270467
98stress fiber assembly (GO:0043149)2.78226894
99positive regulation of mesenchymal cell proliferation (GO:0002053)2.77788845
100cranial suture morphogenesis (GO:0060363)2.75918256
101positive regulation of receptor recycling (GO:0001921)2.75276038
102venous blood vessel morphogenesis (GO:0048845)2.74889105
103cellular response to vitamin (GO:0071295)2.73467405
104extracellular negative regulation of signal transduction (GO:1900116)2.72983764
105extracellular regulation of signal transduction (GO:1900115)2.72983764
106endocardial cushion morphogenesis (GO:0003203)2.71869885
107renal filtration (GO:0097205)2.71194073
108glycosaminoglycan catabolic process (GO:0006027)2.71179306
109regulation of mesenchymal cell proliferation (GO:0010464)2.69550761
110positive regulation of glycogen metabolic process (GO:0070875)2.69289085
111apoptotic cell clearance (GO:0043277)2.69072092
112cardiac myofibril assembly (GO:0055003)2.68628434
113face morphogenesis (GO:0060325)2.66705081
114response to BMP (GO:0071772)2.63646047
115cellular response to BMP stimulus (GO:0071773)2.63646047
116cellular response to vitamin D (GO:0071305)2.63058972
117endocrine hormone secretion (GO:0060986)2.62304204
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.61613540
119negative regulation of BMP signaling pathway (GO:0030514)2.60469037
120G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60030339
121camera-type eye morphogenesis (GO:0048593)2.59129119
122adrenal gland development (GO:0030325)2.57208241
123protein targeting to plasma membrane (GO:0072661)2.56797833
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54492347
125negative regulation of fatty acid transport (GO:2000192)2.54069740
126chondroitin sulfate biosynthetic process (GO:0030206)2.52171345
127regulation of chemokine-mediated signaling pathway (GO:0070099)2.50627981
128cellular response to amino acid stimulus (GO:0071230)2.49893326
129protein localization to cell surface (GO:0034394)2.48093548
130negative regulation of osteoblast proliferation (GO:0033689)2.47356928
131vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.44849147
132artery morphogenesis (GO:0048844)2.43386374
133aminoglycan catabolic process (GO:0006026)2.43225691
134positive regulation of osteoblast proliferation (GO:0033690)2.42953090
135protein trimerization (GO:0070206)2.41988333
136regulation of smooth muscle cell migration (GO:0014910)2.40946706
137regulation of collagen metabolic process (GO:0010712)2.39367714
138cochlea morphogenesis (GO:0090103)2.38175946
139lung vasculature development (GO:0060426)2.36345688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.18590364
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.51652436
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.07691139
4* ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.04743054
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.84970353
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.52554202
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.49935306
8CLOCK_20551151_ChIP-Seq_293T_Human2.47045050
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29997621
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29997621
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.23127908
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.21556380
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20766431
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18827888
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16669892
16* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14457811
17* CJUN_26792858_Chip-Seq_BT549_Human2.07427209
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07358085
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05216914
20AR_21572438_ChIP-Seq_LNCaP_Human2.00115508
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99281316
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.92986917
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.89381434
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86740521
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.86296955
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80318551
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.78762660
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75918361
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.75652704
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73542869
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71764300
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65411209
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.64903469
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62615387
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61413528
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58555340
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54155277
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.51283962
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.50594721
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49911806
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49911806
42* LXR_22292898_ChIP-Seq_THP-1_Human1.49681390
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47538775
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45540748
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42299465
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36975573
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36614153
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.35826707
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.35826707
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35519081
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.34760448
52TP53_18474530_ChIP-ChIP_U2OS_Human1.34698685
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34046296
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.32290893
55SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31784481
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31754496
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.31091650
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30106346
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28749317
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27351573
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26936660
62DROSHA_22980978_ChIP-Seq_HELA_Human1.23733025
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22486709
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21208643
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19536392
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19261712
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.18411376
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18042694
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.17970571
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17359485
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17136327
72KDM2B_26808549_Chip-Seq_K562_Human1.16436476
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16142760
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15528780
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15356451
76TP53_23651856_ChIP-Seq_MEFs_Mouse1.13517778
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13374307
78TP53_16413492_ChIP-PET_HCT116_Human1.13061655
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12831233
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11247188
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10192912
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09939182
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09489386
84SA1_22415368_ChIP-Seq_MEFs_Mouse1.08778961
85RACK7_27058665_Chip-Seq_MCF-7_Human1.08513665
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08200891
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07112843
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.06350056
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06276751
90* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05976565
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.04960894
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04389580
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04387752
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01951830
95SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01022239
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00862388
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00862048
98AHR_22903824_ChIP-Seq_MCF-7_Human1.00140110
99RXR_22108803_ChIP-Seq_LS180_Human0.99884256
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.99613501
101ERG_21242973_ChIP-ChIP_JURKAT_Human0.97092582
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96709658
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96549374
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95953988
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.95403235
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94776924
107P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94053160
108UBF1/2_26484160_Chip-Seq_HMECs_Human0.93196938
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92953024
110TP53_22127205_ChIP-Seq_IMR90_Human0.92612845
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.92489004
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92462623
113* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91314203
114EZH2_22144423_ChIP-Seq_EOC_Human0.91311254
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91048817
116* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90832144
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88780891
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88643350
119CTCF_27219007_Chip-Seq_Bcells_Human0.88032715
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82626391
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82436122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.72357402
2MP0005503_abnormal_tendon_morphology6.90523348
3MP0005275_abnormal_skin_tensile5.36613481
4MP0001958_emphysema3.24838657
5MP0004272_abnormal_basement_membrane3.18744889
6MP0003705_abnormal_hypodermis_morpholog3.09924777
7MP0003279_aneurysm3.06156263
8MP0002108_abnormal_muscle_morphology2.62912435
9MP0000751_myopathy2.60745270
10MP0005508_abnormal_skeleton_morphology2.51917740
11MP0006054_spinal_hemorrhage2.30093342
12MP0009250_abnormal_appendicular_skeleto2.28397385
13MP0005257_abnormal_intraocular_pressure2.19550862
14MP0009384_cardiac_valve_regurgitation2.01855536
15MP0004134_abnormal_chest_morphology2.01388963
16MP0010030_abnormal_orbit_morphology1.90041001
17MP0003385_abnormal_body_wall1.87977181
18MP0002282_abnormal_trachea_morphology1.86568615
19MP0010368_abnormal_lymphatic_system1.77297073
20MP0005623_abnormal_meninges_morphology1.77249825
21MP0002060_abnormal_skin_morphology1.65433784
22MP0001299_abnormal_eye_distance/1.59001367
23MP0002896_abnormal_bone_mineralization1.58746593
24MP0002295_abnormal_pulmonary_circulatio1.56336582
25MP0000428_abnormal_craniofacial_morphol1.52425538
26MP0003942_abnormal_urinary_system1.52416845
27MP0000163_abnormal_cartilage_morphology1.51603743
28MP0000534_abnormal_ureter_morphology1.47755882
29MP0002249_abnormal_larynx_morphology1.45289554
30MP0002115_abnormal_skeleton_extremities1.43599302
31MP0001542_abnormal_bone_strength1.35843036
32MP0002932_abnormal_joint_morphology1.34111542
33MP0000733_abnormal_muscle_development1.32292753
34MP0002837_dystrophic_cardiac_calcinosis1.31018480
35MP0000049_abnormal_middle_ear1.29587528
36MP0005390_skeleton_phenotype1.29353680
37MP0002933_joint_inflammation1.27321563
38MP0000767_abnormal_smooth_muscle1.26373301
39MP0003115_abnormal_respiratory_system1.24239011
40MP0000750_abnormal_muscle_regeneration1.22355990
41MP0009053_abnormal_anal_canal1.19520775
42MP0002938_white_spotting1.19392305
43MP0003122_maternal_imprinting1.16611100
44MP0002113_abnormal_skeleton_development1.15147720
45MP0003566_abnormal_cell_adhesion1.12944820
46MP0005023_abnormal_wound_healing1.12654251
47MP0001243_abnormal_dermal_layer1.12260392
48MP0000537_abnormal_urethra_morphology1.11531148
49MP0003283_abnormal_digestive_organ1.11512860
50MP0002089_abnormal_postnatal_growth/wei1.07969263
51MP0002109_abnormal_limb_morphology1.07636656
52MP0002116_abnormal_craniofacial_bone1.06853921
53MP0005369_muscle_phenotype1.04600788
54MP0003935_abnormal_craniofacial_develop1.01080907
55MP0003755_abnormal_palate_morphology0.97768666
56MP0005367_renal/urinary_system_phenotyp0.97763015
57MP0000516_abnormal_urinary_system0.97763015
58MP0005187_abnormal_penis_morphology0.96161531
59MP0002254_reproductive_system_inflammat0.95137847
60MP0001879_abnormal_lymphatic_vessel0.94451154
61MP0002998_abnormal_bone_remodeling0.94168569
62MP0000762_abnormal_tongue_morphology0.94021033
63MP0005595_abnormal_vascular_smooth0.91536121
64MP0001270_distended_abdomen0.90009874
65MP0002168_other_aberrant_phenotype0.88820178
66MP0000432_abnormal_head_morphology0.88538691
67MP0000749_muscle_degeneration0.88018075
68MP0004087_abnormal_muscle_fiber0.85862952
69MP0003091_abnormal_cell_migration0.85459833
70MP0010386_abnormal_urinary_bladder0.84443646
71MP0005670_abnormal_white_adipose0.84046490
72MP0002233_abnormal_nose_morphology0.83971515
73MP0005164_abnormal_response_to0.83459497
74MP0000013_abnormal_adipose_tissue0.81580154
75MP0009780_abnormal_chondrocyte_physiolo0.81246993
76MP0000759_abnormal_skeletal_muscle0.80947707
77MP0003937_abnormal_limbs/digits/tail_de0.80210601
78MP0005058_abnormal_lysosome_morphology0.78192065
79MP0002114_abnormal_axial_skeleton0.78031095
80MP0000003_abnormal_adipose_tissue0.77932658
81MP0000681_abnormal_thyroid_gland0.77857779
82MP0000462_abnormal_digestive_system0.77842302
83MP0001661_extended_life_span0.77265013
84MP0001849_ear_inflammation0.76347254
85MP0008775_abnormal_heart_ventricle0.76103712
86MP0002128_abnormal_blood_circulation0.76074642
87MP0005171_absent_coat_pigmentation0.75597077
88MP0003045_fibrosis0.75183911
89MP0005248_abnormal_Harderian_gland0.74829655
90MP0001175_abnormal_lung_morphology0.74483426
91MP0005388_respiratory_system_phenotype0.73216775
92MP0002133_abnormal_respiratory_system0.73216775
93MP0004883_abnormal_blood_vessel0.71741335
94MP0003795_abnormal_bone_structure0.71476983
95MP0003950_abnormal_plasma_membrane0.70752952
96MP0005076_abnormal_cell_differentiation0.70426501
97MP0001533_abnormal_skeleton_physiology0.69999825
98MP0004858_abnormal_nervous_system0.69195357
99MP0000343_altered_response_to0.68577615
100MP0001614_abnormal_blood_vessel0.67752210
101MP0002106_abnormal_muscle_physiology0.67009441
102MP0004084_abnormal_cardiac_muscle0.66687574
103MP0002111_abnormal_tail_morphology0.65109527
104MP0004145_abnormal_muscle_electrophysio0.64457140
105MP0005375_adipose_tissue_phenotype0.63060226
106MP0002925_abnormal_cardiovascular_devel0.62835342
107MP0000566_synostosis0.62790614
108MP0003448_altered_tumor_morphology0.62550526
109MP0001348_abnormal_lacrimal_gland0.62460420
110MP0003941_abnormal_skin_development0.62383846
111MP0000249_abnormal_blood_vessel0.61037580
112MP0003329_amyloid_beta_deposits0.61032795
113MP0006138_congestive_heart_failure0.60927343
114MP0004233_abnormal_muscle_weight0.60922897
115MP0001177_atelectasis0.60868046
116MP0005620_abnormal_muscle_contractility0.58972916
117MP0000747_muscle_weakness0.58469220
118MP0004036_abnormal_muscle_relaxation0.57966664
119MP0005165_increased_susceptibility_to0.51817794
120MP0000604_amyloidosis0.50690300
121MP0002971_abnormal_brown_adipose0.49039701
122MP0000538_abnormal_urinary_bladder0.48799351
123MP0000467_abnormal_esophagus_morphology0.47280408

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.36053025
2Premature rupture of membranes (HP:0001788)5.74048266
3Broad metatarsal (HP:0001783)5.51657047
4Ankle contracture (HP:0006466)5.33093146
5Shallow orbits (HP:0000586)4.52894384
6Aortic dissection (HP:0002647)4.46665361
7Type 1 muscle fiber predominance (HP:0003803)4.25655790
8Follicular hyperkeratosis (HP:0007502)3.99931553
9Aortic aneurysm (HP:0004942)3.87106438
10Soft skin (HP:0000977)3.81103986
11Bladder diverticulum (HP:0000015)3.80207677
12Neonatal short-limb short stature (HP:0008921)3.52366181
13Cerebral aneurysm (HP:0004944)3.33776243
14Cervical subluxation (HP:0003308)3.28186595
15Spinal rigidity (HP:0003306)3.25057926
16Short 4th metacarpal (HP:0010044)3.24479867
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24479867
18Increased connective tissue (HP:0009025)3.22231601
19Joint stiffness (HP:0001387)3.16215057
20Slender build (HP:0001533)3.13302428
21Atrophic scars (HP:0001075)3.12591663
22Mitral valve prolapse (HP:0001634)3.04181350
23Dilatation of the ascending aorta (HP:0005111)3.02945117
24Increased variability in muscle fiber diameter (HP:0003557)2.95208182
25Wormian bones (HP:0002645)2.94626315
26Fragile skin (HP:0001030)2.92577549
27Abnormality of the 4th metacarpal (HP:0010012)2.87418580
28Mildly elevated creatine phosphokinase (HP:0008180)2.83433967
29Biconcave vertebral bodies (HP:0004586)2.81596844
30Aortic valve stenosis (HP:0001650)2.81453384
31Vertebral compression fractures (HP:0002953)2.78746041
32Wrist flexion contracture (HP:0001239)2.77465423
33Blue sclerae (HP:0000592)2.76465002
34Abnormality of dentin (HP:0010299)2.76287774
35Peritonitis (HP:0002586)2.74856822
36Hypoplastic ischia (HP:0003175)2.69650297
37Ulnar deviation of the wrist (HP:0003049)2.68141610
38Hyperextensible skin (HP:0000974)2.67520512
39Genu recurvatum (HP:0002816)2.65030355
40Vascular tortuosity (HP:0004948)2.64672275
41Bell-shaped thorax (HP:0001591)2.58518254
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56981065
43Abnormality of skeletal muscle fiber size (HP:0012084)2.56425882
44Overgrowth (HP:0001548)2.55560139
45Wide anterior fontanel (HP:0000260)2.51045178
46Osteoarthritis (HP:0002758)2.49541048
47Joint laxity (HP:0001388)2.44919581
48Breech presentation (HP:0001623)2.43464873
49Pulmonary artery stenosis (HP:0004415)2.40169198
50Abnormality of the ischium (HP:0003174)2.37045364
51Broad ribs (HP:0000885)2.35237058
52Spondylolisthesis (HP:0003302)2.30638758
53Abnormality of the parietal bone (HP:0002696)2.30352372
54Striae distensae (HP:0001065)2.28123639
55Mesomelia (HP:0003027)2.26177617
56Bowel diverticulosis (HP:0005222)2.25848579
57Arterial tortuosity (HP:0005116)2.23289611
58Mitral stenosis (HP:0001718)2.23101104
59Short hallux (HP:0010109)2.20700547
60Mild short stature (HP:0003502)2.20392762
61Ovoid vertebral bodies (HP:0003300)2.18829232
62Flat cornea (HP:0007720)2.18317566
63Nonimmune hydrops fetalis (HP:0001790)2.15763192
64Systemic lupus erythematosus (HP:0002725)2.12913280
65Abnormality of the acetabulum (HP:0003170)2.10665314
66Aneurysm (HP:0002617)2.09732373
67Muscle fiber splitting (HP:0003555)2.08986361
68Broad long bones (HP:0005622)2.08786812
69Hypoplasia of the iris (HP:0007676)2.07942563
70Hip contracture (HP:0003273)2.07742103
71Round ear (HP:0100830)2.07694243
72Abnormality of complement system (HP:0005339)2.07621537
73Emphysema (HP:0002097)2.07352910
74Deviation of the hallux (HP:0010051)2.06876729
75Hypoventilation (HP:0002791)2.06157432
76Infantile muscular hypotonia (HP:0008947)2.05447947
77Elbow flexion contracture (HP:0002987)2.05016878
78Calcaneovalgus deformity (HP:0001848)2.04926150
79Coronal craniosynostosis (HP:0004440)2.04651190
80Limited hip movement (HP:0008800)2.04123062
81Exostoses (HP:0100777)2.02626127
82Thin bony cortex (HP:0002753)2.01832918
83Asymmetry of the thorax (HP:0001555)2.01634349
84Deformed tarsal bones (HP:0008119)2.01591686
85Venous insufficiency (HP:0005293)1.99453889
86Vitreoretinal degeneration (HP:0000655)1.98685609
87Venous abnormality (HP:0002624)1.98638480
88Aplasia/Hypoplasia of the hallux (HP:0008362)1.98094080
89Protruding ear (HP:0000411)1.97056874
90Abnormal delivery (HP:0001787)1.96274311
91Mitral regurgitation (HP:0001653)1.96124323
92Abnormality of skull ossification (HP:0002703)1.94737878
93Camptodactyly of toe (HP:0001836)1.91900806
94Aplasia involving bones of the upper limbs (HP:0009823)1.91341027
95Aplasia of the phalanges of the hand (HP:0009802)1.91341027
96Aplasia involving bones of the extremities (HP:0009825)1.91341027
97Ulnar bowing (HP:0003031)1.91062962
98Epiphyseal dysplasia (HP:0002656)1.91029647
99Hallux valgus (HP:0001822)1.89664284
100Ectopia lentis (HP:0001083)1.89090897
101Delayed cranial suture closure (HP:0000270)1.88580186
102Osteolytic defects of the hand bones (HP:0009699)1.88422449
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.88422449
104Tarsal synostosis (HP:0008368)1.87698571
105Bronchomalacia (HP:0002780)1.87694714
106Persistence of primary teeth (HP:0006335)1.86265584
107Coxa vara (HP:0002812)1.85442665
108Generalized amyotrophy (HP:0003700)1.85185350
109Broad toe (HP:0001837)1.84296638
110Obstructive sleep apnea (HP:0002870)1.83868884
111Midline defect of the nose (HP:0004122)1.82276905
112Inguinal hernia (HP:0000023)1.81987221
113Aortic regurgitation (HP:0001659)1.81913752
114Disproportionate tall stature (HP:0001519)1.81576747
115Complement deficiency (HP:0004431)1.80616541
116Delayed closure of the anterior fontanelle (HP:0001476)1.80507109
117Decreased skull ossification (HP:0004331)1.80343358
118Turricephaly (HP:0000262)1.80266986
119Cupped ribs (HP:0000887)1.79371017
120Knee flexion contracture (HP:0006380)1.79339660
121Broad phalanx (HP:0006009)1.79254579
122Redundant skin (HP:0001582)1.78082120
123Renal duplication (HP:0000075)1.76659691
124Distal arthrogryposis (HP:0005684)1.76515262
125Narrow nasal bridge (HP:0000446)1.75477114
126Keratoconus (HP:0000563)1.74514466
127Increased corneal curvature (HP:0100692)1.74514466
128Osteopenia (HP:0000938)1.73300183
129Hypoplasia of the odontoid process (HP:0003311)1.72680204
130Thin skin (HP:0000963)1.72562138
131Premature skin wrinkling (HP:0100678)1.70626630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.79963092
2TRIB34.20295725
3PDGFRA3.89804637
4TTN3.58206847
5SIK13.36505838
6LATS13.19902874
7EPHA32.98149329
8EPHB22.54123651
9TESK12.30098815
10MYLK2.29144258
11FGFR22.23526930
12LATS22.17001335
13DMPK2.07647933
14PKN22.02331688
15TGFBR22.01161084
16RIPK11.96201711
17ERN11.89735694
18LMTK21.81377170
19MAP3K61.61762715
20ROCK11.50226647
21PAK21.50012015
22LIMK11.49151520
23FER1.47899921
24PDGFRB1.45811395
25AKT31.38218201
26BMX1.30787107
27ABL21.30314577
28FGFR11.29910507
29ROCK21.28823199
30PIK3CA1.28372292
31FGFR41.25228842
32PTK61.23604740
33STK38L1.22331347
34STK31.22299919
35MET1.22011364
36ILK1.20765797
37EPHB11.18710974
38GRK51.12105791
39PTK21.05636058
40MAPKAPK31.03638833
41CAMK1D1.02149790
42PHKG11.01549146
43PHKG21.01549146
44MAPK151.01334429
45PRKD31.00239064
46NEK90.98216353
47PTK2B0.96775433
48PAK40.88023228
49PAK30.87733857
50CAMK1G0.87577662
51PRKCH0.87100242
52NTRK10.86936484
53MTOR0.84058004
54LRRK20.83556776
55TRPM70.83539732
56RET0.83305570
57ERBB30.77677693
58MAP3K70.77342144
59PRPF4B0.76955827
60TYK20.75552348
61FGFR30.74701517
62WNK10.73755260
63NUAK10.71868357
64OBSCN0.71326636
65JAK10.68729762
66GRK10.68510818
67PRKD10.67672675
68RPS6KC10.65865427
69RPS6KL10.65865427
70MAPK40.65616369
71HIPK20.63845646
72MAP2K10.62951144
73INSRR0.61666225
74PRKG20.60947206
75MAP3K100.60028623
76CDC42BPA0.59597118
77MOS0.58546584
78CAMK10.58230501
79PAK60.57486476
80EEF2K0.56254607
81ICK0.55598403
82PLK20.53022830
83PRKD20.52454605
84MST1R0.52154565
85FRK0.50638995
86RPS6KA60.49742744
87STK240.48367420
88FLT30.48363703
89NLK0.47829490
90TIE10.45448914
91KIT0.45085246
92GSK3A0.44540496
93PIM20.43064777
94MAP3K30.42241816
95PAK10.41390867
96CAMK40.41299865
97JAK30.41042375
98TGFBR10.40667441
99INSR0.40500397
100SRC0.40375198
101PRKCE0.39248862
102ARAF0.37995387
103MAPKAPK20.37070066
104ADRBK10.36978549
105ERBB20.36954488
106PIK3CG0.36723259
107DYRK1B0.36197665
108CAMK2D0.35322219
109TYRO30.34833738
110ZAP700.34652985
111MARK10.34413550
112MAP2K30.33229852
113MAPK120.33085410
114DAPK30.32662512
115PDPK10.31422045
116IGF1R0.31317698
117MAPK10.31204392
118MAPK70.30084843
119MAP2K20.28809670
120KSR20.28386255
121CHUK0.27892218
122CDK60.27153023
123RPS6KA40.26747123
124CAMK2G0.24218441
125STK380.24085784
126RPS6KA20.21572773
127CDK120.21540214
128PRKG10.21429032
129TAOK10.21257096
130MARK20.20433657

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.66944883
2Protein digestion and absorption_Homo sapiens_hsa049743.55422923
3Focal adhesion_Homo sapiens_hsa045103.00739741
4Basal cell carcinoma_Homo sapiens_hsa052172.82968670
5Hedgehog signaling pathway_Homo sapiens_hsa043402.63381027
6Dilated cardiomyopathy_Homo sapiens_hsa054142.35815395
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.28359154
8TGF-beta signaling pathway_Homo sapiens_hsa043502.21483224
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16745155
10Proteoglycans in cancer_Homo sapiens_hsa052052.11477612
11Amoebiasis_Homo sapiens_hsa051462.09720326
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07318590
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00437002
14Hippo signaling pathway_Homo sapiens_hsa043901.72802175
15Adherens junction_Homo sapiens_hsa045201.70830317
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67108069
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64759326
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.58168622
19Malaria_Homo sapiens_hsa051441.49012320
20Small cell lung cancer_Homo sapiens_hsa052221.47622841
21Wnt signaling pathway_Homo sapiens_hsa043101.46462177
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45101481
23Melanoma_Homo sapiens_hsa052181.43182368
24Other glycan degradation_Homo sapiens_hsa005111.39409600
25Viral myocarditis_Homo sapiens_hsa054161.34042983
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28816261
27Pathways in cancer_Homo sapiens_hsa052001.27435192
28MicroRNAs in cancer_Homo sapiens_hsa052061.20009975
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19713822
30Prostate cancer_Homo sapiens_hsa052151.18877198
31Chronic myeloid leukemia_Homo sapiens_hsa052201.15043517
32Melanogenesis_Homo sapiens_hsa049161.13416905
33Pertussis_Homo sapiens_hsa051331.12188940
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06432388
35Axon guidance_Homo sapiens_hsa043601.01605374
36Glioma_Homo sapiens_hsa052141.01568645
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00419569
38Insulin resistance_Homo sapiens_hsa049311.00066391
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97820275
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.96264274
41Rap1 signaling pathway_Homo sapiens_hsa040150.94749778
42Lysosome_Homo sapiens_hsa041420.94723825
43Bladder cancer_Homo sapiens_hsa052190.94566644
44Toxoplasmosis_Homo sapiens_hsa051450.94185049
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92717095
46Colorectal cancer_Homo sapiens_hsa052100.92056345
47Ovarian steroidogenesis_Homo sapiens_hsa049130.91439907
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89265066
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87627825
50Platelet activation_Homo sapiens_hsa046110.86605363
51Endometrial cancer_Homo sapiens_hsa052130.84386579
52Pancreatic cancer_Homo sapiens_hsa052120.83597661
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.82026058
54Notch signaling pathway_Homo sapiens_hsa043300.81586349
55Estrogen signaling pathway_Homo sapiens_hsa049150.80565381
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78088811
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77868194
58Staphylococcus aureus infection_Homo sapiens_hsa051500.77200729
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.76497735
60cAMP signaling pathway_Homo sapiens_hsa040240.75515329
61Thyroid hormone synthesis_Homo sapiens_hsa049180.75356362
62AMPK signaling pathway_Homo sapiens_hsa041520.75271171
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74925140
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74628300
65Tight junction_Homo sapiens_hsa045300.72623020
66Lysine degradation_Homo sapiens_hsa003100.72505415
67Renin secretion_Homo sapiens_hsa049240.71364444
68Cocaine addiction_Homo sapiens_hsa050300.71234888
69Gap junction_Homo sapiens_hsa045400.70249074
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.66288381
71Insulin signaling pathway_Homo sapiens_hsa049100.65896899
72Ras signaling pathway_Homo sapiens_hsa040140.64801150
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63865253
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63731010
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62166466
76HTLV-I infection_Homo sapiens_hsa051660.62163355
77Renal cell carcinoma_Homo sapiens_hsa052110.60310329
78Phagosome_Homo sapiens_hsa041450.60245039
79GnRH signaling pathway_Homo sapiens_hsa049120.60169904
80TNF signaling pathway_Homo sapiens_hsa046680.59900921
81Endocytosis_Homo sapiens_hsa041440.57798986
82Calcium signaling pathway_Homo sapiens_hsa040200.57776067
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.57775622
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.56599720
85Vibrio cholerae infection_Homo sapiens_hsa051100.56456078
86Arachidonic acid metabolism_Homo sapiens_hsa005900.55301396
87PPAR signaling pathway_Homo sapiens_hsa033200.55271851
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54977940
89Histidine metabolism_Homo sapiens_hsa003400.54131361
90MAPK signaling pathway_Homo sapiens_hsa040100.52946049
91Starch and sucrose metabolism_Homo sapiens_hsa005000.52822156
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52214917
93Tyrosine metabolism_Homo sapiens_hsa003500.52035172
94mTOR signaling pathway_Homo sapiens_hsa041500.51628559
95Oxytocin signaling pathway_Homo sapiens_hsa049210.51564844
96HIF-1 signaling pathway_Homo sapiens_hsa040660.50308154
97Dorso-ventral axis formation_Homo sapiens_hsa043200.49393002
98Insulin secretion_Homo sapiens_hsa049110.48120877
99Type II diabetes mellitus_Homo sapiens_hsa049300.47273731
100Gastric acid secretion_Homo sapiens_hsa049710.47033503
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45661616
102Mineral absorption_Homo sapiens_hsa049780.45398677
103FoxO signaling pathway_Homo sapiens_hsa040680.45063276
104Galactose metabolism_Homo sapiens_hsa000520.43657801
105Circadian rhythm_Homo sapiens_hsa047100.42456766
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42301668
107Phenylalanine metabolism_Homo sapiens_hsa003600.41640104
108Nitrogen metabolism_Homo sapiens_hsa009100.40828806
109Glucagon signaling pathway_Homo sapiens_hsa049220.40670454
110Choline metabolism in cancer_Homo sapiens_hsa052310.40296408
111Renin-angiotensin system_Homo sapiens_hsa046140.40041919
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39277456
113Prion diseases_Homo sapiens_hsa050200.37649871
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37532702
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36473760
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36071809
117Fatty acid metabolism_Homo sapiens_hsa012120.35563744
118Hepatitis B_Homo sapiens_hsa051610.35084577
119Complement and coagulation cascades_Homo sapiens_hsa046100.34809158
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34416328
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.33596942
122Thyroid cancer_Homo sapiens_hsa052160.33546568
123ErbB signaling pathway_Homo sapiens_hsa040120.32600816
124Acute myeloid leukemia_Homo sapiens_hsa052210.32110103

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