ISCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.60931361
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.54961660
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.19497844
4ATP synthesis coupled proton transport (GO:0015986)7.19497844
5respiratory electron transport chain (GO:0022904)6.63309215
6electron transport chain (GO:0022900)6.49406167
7chaperone-mediated protein transport (GO:0072321)5.65421540
8protein complex biogenesis (GO:0070271)5.32688339
9signal peptide processing (GO:0006465)5.14887506
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.04147828
11NADH dehydrogenase complex assembly (GO:0010257)5.04147828
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.04147828
13protein neddylation (GO:0045116)4.98226774
14prenylation (GO:0097354)4.78311441
15protein prenylation (GO:0018342)4.78311441
16mitochondrial respiratory chain complex assembly (GO:0033108)4.72136954
17respiratory chain complex IV assembly (GO:0008535)4.46012289
18hydrogen ion transmembrane transport (GO:1902600)4.22785327
19ubiquinone metabolic process (GO:0006743)4.12287640
20ubiquinone biosynthetic process (GO:0006744)4.11768016
21quinone biosynthetic process (GO:1901663)4.11768016
22presynaptic membrane assembly (GO:0097105)4.09985103
23dopamine transport (GO:0015872)4.04381662
24proteasome assembly (GO:0043248)4.03427044
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.02924210
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.02924210
27oxidative phosphorylation (GO:0006119)4.00542018
28DNA deamination (GO:0045006)3.94514901
29chromatin remodeling at centromere (GO:0031055)3.92350502
30cytochrome complex assembly (GO:0017004)3.89359496
31presynaptic membrane organization (GO:0097090)3.85208466
32CENP-A containing nucleosome assembly (GO:0034080)3.83194994
33proton transport (GO:0015992)3.82183420
34ATP biosynthetic process (GO:0006754)3.82079571
35fatty acid elongation (GO:0030497)3.81522875
36central nervous system myelination (GO:0022010)3.81512900
37axon ensheathment in central nervous system (GO:0032291)3.81512900
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.81136120
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.77764426
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.76115618
41hydrogen transport (GO:0006818)3.74439330
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.73729448
43cullin deneddylation (GO:0010388)3.71369407
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70441833
45protein targeting to mitochondrion (GO:0006626)3.69163625
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69017572
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64582544
48inner mitochondrial membrane organization (GO:0007007)3.64186194
49GTP biosynthetic process (GO:0006183)3.62661419
50platelet dense granule organization (GO:0060155)3.59022437
51regulation of mitochondrial translation (GO:0070129)3.56348101
52ATP hydrolysis coupled proton transport (GO:0015991)3.52138394
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52138394
54establishment of integrated proviral latency (GO:0075713)3.50469968
55mannosylation (GO:0097502)3.46406487
56establishment of protein localization to mitochondrion (GO:0072655)3.44755221
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44061042
58aerobic respiration (GO:0009060)3.40632437
59water-soluble vitamin biosynthetic process (GO:0042364)3.40593941
60protein deneddylation (GO:0000338)3.39192070
61quinone metabolic process (GO:1901661)3.37218991
62base-excision repair, AP site formation (GO:0006285)3.34957335
63branched-chain amino acid catabolic process (GO:0009083)3.33489336
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30222808
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26091557
66protein localization to mitochondrion (GO:0070585)3.24345766
67regulation of cellular amino acid metabolic process (GO:0006521)3.22746403
68establishment of viral latency (GO:0019043)3.22548900
69DNA double-strand break processing (GO:0000729)3.22496167
70* metallo-sulfur cluster assembly (GO:0031163)3.21787119
71* iron-sulfur cluster assembly (GO:0016226)3.21787119
72ribosomal small subunit biogenesis (GO:0042274)3.19642463
73dopamine biosynthetic process (GO:0042416)3.19447003
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18148916
75regulation of mitotic spindle checkpoint (GO:1903504)3.17090709
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17090709
77termination of RNA polymerase III transcription (GO:0006386)3.15750150
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.15750150
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.14216113
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13743178
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.13743178
82positive regulation of mitochondrial fission (GO:0090141)3.13512412
83pyrimidine nucleotide catabolic process (GO:0006244)3.12900716
84DNA ligation (GO:0006266)3.11746935
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08933370
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07833317
87histone exchange (GO:0043486)3.07758926
88DNA damage response, detection of DNA damage (GO:0042769)3.07602409
89positive regulation of ligase activity (GO:0051351)3.06523486
90nucleotide transmembrane transport (GO:1901679)3.05692314
91deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05628009
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04135665
93kinetochore assembly (GO:0051382)3.01470737
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00216779
95deoxyribonucleotide catabolic process (GO:0009264)2.99536073
96mitochondrial transport (GO:0006839)2.98702639
97protein-cofactor linkage (GO:0018065)2.98479591
98nucleoside triphosphate biosynthetic process (GO:0009142)2.95954618
99preassembly of GPI anchor in ER membrane (GO:0016254)2.95387088
100regulation of oxidative phosphorylation (GO:0002082)2.95261886
101amino acid salvage (GO:0043102)2.94724557
102L-methionine salvage (GO:0071267)2.94724557
103L-methionine biosynthetic process (GO:0071265)2.94724557
104replication fork processing (GO:0031297)2.94609072
105transferrin transport (GO:0033572)2.91530682
106peptidyl-histidine modification (GO:0018202)2.90799035
107deoxyribose phosphate catabolic process (GO:0046386)2.90514310
108DNA catabolic process, exonucleolytic (GO:0000738)2.87501305
109tRNA processing (GO:0008033)2.86896080
110GPI anchor biosynthetic process (GO:0006506)2.86451880
111negative regulation of ligase activity (GO:0051352)2.84116758
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84116758
113rRNA modification (GO:0000154)2.83066052
114UTP biosynthetic process (GO:0006228)2.82156317
115postsynaptic membrane organization (GO:0001941)2.82072276
116regulation of cellular respiration (GO:0043457)2.81888185
117sequestering of actin monomers (GO:0042989)2.81644928
118guanosine-containing compound biosynthetic process (GO:1901070)2.81530832
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80827532
120intracellular protein transmembrane import (GO:0044743)2.80320051
121antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79213577
122spliceosomal snRNP assembly (GO:0000387)2.78701701
123cotranslational protein targeting to membrane (GO:0006613)2.78447433
124ribosomal small subunit assembly (GO:0000028)2.78148596
125pseudouridine synthesis (GO:0001522)2.77007109
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75678381
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75678381
128C-terminal protein lipidation (GO:0006501)2.75390396
129protoporphyrinogen IX biosynthetic process (GO:0006782)2.74195204
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73594967
131kinetochore organization (GO:0051383)2.73486669
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.73389393
133phagosome maturation (GO:0090382)2.72688083
134signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72638528
135signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72638528
136signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72638528
137positive regulation of prostaglandin secretion (GO:0032308)2.72295679
138regulation of cellular amine metabolic process (GO:0033238)2.70204439
139protein K6-linked ubiquitination (GO:0085020)2.69765349
140protein targeting to ER (GO:0045047)2.69327404
141GPI anchor metabolic process (GO:0006505)2.69219134
142substantia nigra development (GO:0021762)2.68897590
143protein localization to endoplasmic reticulum (GO:0070972)2.66796275
144ferric iron transport (GO:0015682)2.65513390
145trivalent inorganic cation transport (GO:0072512)2.65513390
146SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65432242
147long-chain fatty acid biosynthetic process (GO:0042759)2.64936827
148viral protein processing (GO:0019082)2.64924957
149positive regulation of protein sumoylation (GO:0033235)2.64745994
1507-methylguanosine mRNA capping (GO:0006370)2.61630427
151CTP metabolic process (GO:0046036)2.61517866
152CTP biosynthetic process (GO:0006241)2.61517866
153regulation of dopamine metabolic process (GO:0042053)2.61067270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.85332312
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44312450
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.91863650
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47565249
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45640425
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.45498893
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38547570
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.31363348
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25090766
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.11491346
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07616136
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.71363081
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.70642855
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68800558
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65523255
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56398372
17ZNF274_21170338_ChIP-Seq_K562_Hela2.55427501
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51721991
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36591180
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24464777
21TAF15_26573619_Chip-Seq_HEK293_Human2.24031969
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09462382
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96663118
24IRF1_19129219_ChIP-ChIP_H3396_Human1.92801535
25VDR_22108803_ChIP-Seq_LS180_Human1.86560759
26VDR_23849224_ChIP-Seq_CD4+_Human1.86518712
27MYC_18940864_ChIP-ChIP_HL60_Human1.85465645
28E2F7_22180533_ChIP-Seq_HELA_Human1.84567795
29EZH2_22144423_ChIP-Seq_EOC_Human1.82901255
30GBX2_23144817_ChIP-Seq_PC3_Human1.81312850
31IGF1R_20145208_ChIP-Seq_DFB_Human1.79618781
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74543792
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73886497
34DCP1A_22483619_ChIP-Seq_HELA_Human1.70359161
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69094743
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68075261
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65997268
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.63173872
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62668815
40* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62038265
41ELK1_19687146_ChIP-ChIP_HELA_Human1.59911968
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56277621
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55561647
44CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.51519093
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47851231
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47260409
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45877593
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43904419
49FUS_26573619_Chip-Seq_HEK293_Human1.40229825
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39224276
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35372728
52FOXP3_21729870_ChIP-Seq_TREG_Human1.34640927
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31754633
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31150839
55TP53_22573176_ChIP-Seq_HFKS_Human1.30421913
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28193332
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28141750
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26910588
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.26744583
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23321145
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23205753
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.20099586
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19529160
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.18798245
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17381774
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17339337
67P300_19829295_ChIP-Seq_ESCs_Human1.17031257
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15801088
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.14878983
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10670307
71ER_23166858_ChIP-Seq_MCF-7_Human1.09510770
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.08485330
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08246372
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.07308220
75GABP_19822575_ChIP-Seq_HepG2_Human1.06960490
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06879087
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.06621813
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05826079
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05314144
80AR_20517297_ChIP-Seq_VCAP_Human1.03720245
81* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02844948
82KDM5A_27292631_Chip-Seq_BREAST_Human1.02682921
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02361186
84HTT_18923047_ChIP-ChIP_STHdh_Human1.02091266
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01206170
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.01055701
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00055724
88CIITA_25753668_ChIP-Seq_RAJI_Human0.99679825
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99502797
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.98875685
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98614961
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.98360473
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.97780074
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97780074
95TTF2_22483619_ChIP-Seq_HELA_Human0.97298328
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95775016
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.94086126
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93937287
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93160554
100EWS_26573619_Chip-Seq_HEK293_Human0.91454528
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91445673
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91257285
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90381489
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90083597
105* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89869506
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89562902
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88824954
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.87875926
109TAL1_26923725_Chip-Seq_HPCs_Mouse0.87347404
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86736004
111RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85539225
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85290369
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83569569
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82940792
115CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82848556
116P53_22387025_ChIP-Seq_ESCs_Mouse0.82519351
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82514397
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82501473
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81957674
120SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81204377
121REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81072127
122P300_18555785_Chip-Seq_ESCs_Mouse0.81004408
123XRN2_22483619_ChIP-Seq_HELA_Human0.80840648
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80609964
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80498878
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80234669
127RNF2_27304074_Chip-Seq_NSC_Mouse0.78863549
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78833781
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.78441024
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78427945
131SOX2_19829295_ChIP-Seq_ESCs_Human0.78199116
132NANOG_19829295_ChIP-Seq_ESCs_Human0.78199116
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75668055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.98711413
2MP0001905_abnormal_dopamine_level3.56055650
3MP0008058_abnormal_DNA_repair3.46033628
4MP0001986_abnormal_taste_sensitivity3.27287104
5MP0008877_abnormal_DNA_methylation3.05578408
6MP0003880_abnormal_central_pattern2.93460579
7MP0009379_abnormal_foot_pigmentation2.89150170
8MP0004147_increased_porphyrin_level2.86045434
9MP0010094_abnormal_chromosome_stability2.60295235
10MP0003693_abnormal_embryo_hatching2.41523203
11MP0006036_abnormal_mitochondrial_physio2.38989644
12MP0002638_abnormal_pupillary_reflex2.26487467
13MP0006276_abnormal_autonomic_nervous2.24251361
14MP0002102_abnormal_ear_morphology2.16981316
15MP0005171_absent_coat_pigmentation2.13519760
16MP0003718_maternal_effect2.08269685
17MP0002736_abnormal_nociception_after1.99030925
18MP0002272_abnormal_nervous_system1.96745647
19MP0000372_irregular_coat_pigmentation1.93799453
20MP0003786_premature_aging1.91095225
21MP0004142_abnormal_muscle_tone1.85120818
22MP0005646_abnormal_pituitary_gland1.84329688
23MP0002876_abnormal_thyroid_physiology1.83026114
24MP0002653_abnormal_ependyma_morphology1.80672467
25MP0002837_dystrophic_cardiac_calcinosis1.80519018
26MP0003122_maternal_imprinting1.80366124
27MP0003186_abnormal_redox_activity1.77990546
28MP0009046_muscle_twitch1.75838947
29MP0010386_abnormal_urinary_bladder1.75536187
30MP0004957_abnormal_blastocyst_morpholog1.75521180
31MP0004043_abnormal_pH_regulation1.74664672
32MP0001984_abnormal_olfaction1.73886664
33MP0002064_seizures1.70086571
34MP0000920_abnormal_myelination1.68646576
35MP0001968_abnormal_touch/_nociception1.67533294
36MP0004133_heterotaxia1.67531714
37MP0003806_abnormal_nucleotide_metabolis1.65588865
38MP0002735_abnormal_chemical_nociception1.63081148
39MP0003111_abnormal_nucleus_morphology1.63034593
40MP0001293_anophthalmia1.61830952
41MP0003183_abnormal_peptide_metabolism1.60541519
42MP0001485_abnormal_pinna_reflex1.60164154
43MP0005409_darkened_coat_color1.60071416
44MP0003656_abnormal_erythrocyte_physiolo1.59929102
45MP0001188_hyperpigmentation1.59308235
46MP0005253_abnormal_eye_physiology1.56687458
47MP0003787_abnormal_imprinting1.55357063
48MP0002734_abnormal_mechanical_nocicepti1.54812701
49MP0009745_abnormal_behavioral_response1.54760079
50MP0008932_abnormal_embryonic_tissue1.53057640
51MP0003136_yellow_coat_color1.52016541
52MP0008875_abnormal_xenobiotic_pharmacok1.50475368
53MP0005645_abnormal_hypothalamus_physiol1.49158664
54MP0003077_abnormal_cell_cycle1.48992715
55MP0003011_delayed_dark_adaptation1.48028777
56MP0001501_abnormal_sleep_pattern1.47877963
57MP0008995_early_reproductive_senescence1.46015726
58MP0003195_calcinosis1.45032827
59MP0009697_abnormal_copulation1.39786976
60MP0001486_abnormal_startle_reflex1.35318821
61MP0005379_endocrine/exocrine_gland_phen1.34178742
62MP0006035_abnormal_mitochondrial_morpho1.33649985
63MP0005408_hypopigmentation1.32863725
64MP0001970_abnormal_pain_threshold1.32747971
65MP0002572_abnormal_emotion/affect_behav1.32418462
66MP0002938_white_spotting1.32351158
67MP0003121_genomic_imprinting1.29850572
68MP0003724_increased_susceptibility_to1.25780486
69MP0002822_catalepsy1.23894015
70MP0005386_behavior/neurological_phenoty1.22437552
71MP0004924_abnormal_behavior1.22437552
72MP0002234_abnormal_pharynx_morphology1.22223319
73MP0008789_abnormal_olfactory_epithelium1.21936873
74MP0004742_abnormal_vestibular_system1.21486609
75MP0003635_abnormal_synaptic_transmissio1.21094901
76MP0002067_abnormal_sensory_capabilities1.20049975
77MP0005535_abnormal_body_temperature1.19755060
78MP0005084_abnormal_gallbladder_morpholo1.19269120
79MP0000358_abnormal_cell_content/1.18347452
80MP0001764_abnormal_homeostasis1.18327678
81MP0002733_abnormal_thermal_nociception1.16599392
82MP0005423_abnormal_somatic_nervous1.15068359
83MP0002210_abnormal_sex_determination1.13692386
84MP0002163_abnormal_gland_morphology1.13373059
85MP0001929_abnormal_gametogenesis1.12376205
86MP0008007_abnormal_cellular_replicative1.11221688
87MP0006292_abnormal_olfactory_placode1.10918417
88MP0005551_abnormal_eye_electrophysiolog1.10054941
89MP0002277_abnormal_respiratory_mucosa1.07976170
90MP0005671_abnormal_response_to1.06647387
91MP0004270_analgesia1.06320485
92MP0001963_abnormal_hearing_physiology1.04561981
93MP0003567_abnormal_fetal_cardiomyocyte1.04038170
94MP0001502_abnormal_circadian_rhythm1.03846830
95MP0001440_abnormal_grooming_behavior1.03083256
96MP0005636_abnormal_mineral_homeostasis0.99896416
97MP0002132_abnormal_respiratory_system0.98535289
98MP0000516_abnormal_urinary_system0.98467195
99MP0005367_renal/urinary_system_phenotyp0.98467195
100MP0000653_abnormal_sex_gland0.98014371
101MP0002063_abnormal_learning/memory/cond0.97535636
102MP0009785_altered_susceptibility_to0.97233893
103MP0001145_abnormal_male_reproductive0.97105192
104MP0004215_abnormal_myocardial_fiber0.96100794
105MP0002160_abnormal_reproductive_system0.95757724
106MP0005389_reproductive_system_phenotype0.95387467
107MP0005410_abnormal_fertilization0.95248176
108MP0000749_muscle_degeneration0.94079394
109MP0000566_synostosis0.93663348
110MP0005499_abnormal_olfactory_system0.93096059
111MP0005394_taste/olfaction_phenotype0.93096059
112MP0002229_neurodegeneration0.93046248
113MP0001661_extended_life_span0.91237607
114MP0003690_abnormal_glial_cell0.91143580
115MP0002751_abnormal_autonomic_nervous0.90791206
116MP0002148_abnormal_hypersensitivity_rea0.90052524
117MP0000049_abnormal_middle_ear0.89247174
118MP0008872_abnormal_physiological_respon0.88256789
119MP0004145_abnormal_muscle_electrophysio0.87615481
120MP0003937_abnormal_limbs/digits/tail_de0.86765701
121MP0002233_abnormal_nose_morphology0.86418977
122MP0005083_abnormal_biliary_tract0.83953454
123MP0005332_abnormal_amino_acid0.82935906
124MP0006072_abnormal_retinal_apoptosis0.82885429
125MP0001664_abnormal_digestion0.82567885
126MP0003646_muscle_fatigue0.82200446
127MP0004036_abnormal_muscle_relaxation0.82144880
128MP0001919_abnormal_reproductive_system0.82125211
129MP0002090_abnormal_vision0.81269537
130MP0003137_abnormal_impulse_conducting0.80917286
131MP0003698_abnormal_male_reproductive0.80792813
132MP0000026_abnormal_inner_ear0.79806460
133MP0000647_abnormal_sebaceous_gland0.79076388
134MP0000631_abnormal_neuroendocrine_gland0.78715049
135MP0002066_abnormal_motor_capabilities/c0.77625161
136MP0002184_abnormal_innervation0.77449759
137MP0005584_abnormal_enzyme/coenzyme_acti0.77384194
138MP0001119_abnormal_female_reproductive0.76281323
139MP0002557_abnormal_social/conspecific_i0.75983029
140MP0001727_abnormal_embryo_implantation0.75100719
141MP0005075_abnormal_melanosome_morpholog0.74738938
142MP0005195_abnormal_posterior_eye0.73310720
143MP0003119_abnormal_digestive_system0.73058338
144MP0005391_vision/eye_phenotype0.72492287
145MP0006054_spinal_hemorrhage0.71823819
146MP0005387_immune_system_phenotype0.71609696
147MP0001790_abnormal_immune_system0.71609696
148MP0003634_abnormal_glial_cell0.71274011
149MP0010030_abnormal_orbit_morphology0.68798117
150MP0008569_lethality_at_weaning0.68604073
151MP0005266_abnormal_metabolism0.64169059

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.61540575
2Mitochondrial inheritance (HP:0001427)6.03305840
3Abnormal mitochondria in muscle tissue (HP:0008316)5.99847497
4Hepatocellular necrosis (HP:0001404)5.53678661
5Progressive macrocephaly (HP:0004481)5.45087182
6Acute encephalopathy (HP:0006846)5.43762305
7Increased CSF lactate (HP:0002490)5.21376534
8Hepatic necrosis (HP:0002605)4.87563918
9Increased hepatocellular lipid droplets (HP:0006565)4.54344925
10Renal Fanconi syndrome (HP:0001994)4.41204299
11Hypothermia (HP:0002045)4.18022468
12Lipid accumulation in hepatocytes (HP:0006561)4.17174008
133-Methylglutaconic aciduria (HP:0003535)3.86926463
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.81837221
15Neuroendocrine neoplasm (HP:0100634)3.75023786
16Cerebral edema (HP:0002181)3.73645665
17Abnormality of glycolysis (HP:0004366)3.68418852
18Increased serum pyruvate (HP:0003542)3.68418852
19Lactic acidosis (HP:0003128)3.51491400
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.50599780
21Respiratory failure (HP:0002878)3.50415418
22Increased intramyocellular lipid droplets (HP:0012240)3.46211382
23Optic disc pallor (HP:0000543)3.45424845
24Pheochromocytoma (HP:0002666)3.44862640
25Leukodystrophy (HP:0002415)3.44033922
26Exercise intolerance (HP:0003546)3.39765946
27Increased serum lactate (HP:0002151)3.32276460
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32101227
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32101227
30Hyperglycinemia (HP:0002154)3.12246423
31Increased muscle lipid content (HP:0009058)3.09595590
32Abnormality of renal resorption (HP:0011038)3.09348416
33Limb dystonia (HP:0002451)3.08016370
34Exertional dyspnea (HP:0002875)3.01695183
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.89570562
36Split foot (HP:0001839)2.85543409
37Parakeratosis (HP:0001036)2.78541220
38Colon cancer (HP:0003003)2.69531554
39Medial flaring of the eyebrow (HP:0010747)2.68849134
40Respiratory difficulties (HP:0002880)2.64810505
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46823188
42Abnormality of the labia minora (HP:0012880)2.44157878
43Abnormality of cells of the erythroid lineage (HP:0012130)2.43996026
44Congenital primary aphakia (HP:0007707)2.40097887
45Sclerocornea (HP:0000647)2.39232333
46Type I transferrin isoform profile (HP:0003642)2.38989053
47Hyperglycinuria (HP:0003108)2.37900431
48Abnormal number of erythroid precursors (HP:0012131)2.37563833
49Gait imbalance (HP:0002141)2.37372764
50Abnormality of glycine metabolism (HP:0010895)2.35460061
51Abnormality of serine family amino acid metabolism (HP:0010894)2.35460061
52Nephronophthisis (HP:0000090)2.34377104
53CNS demyelination (HP:0007305)2.34199429
54Nephrogenic diabetes insipidus (HP:0009806)2.33459124
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32385034
56Abnormality of alanine metabolism (HP:0010916)2.32385034
57Hyperalaninemia (HP:0003348)2.32385034
58X-linked dominant inheritance (HP:0001423)2.31865418
59Abolished electroretinogram (ERG) (HP:0000550)2.31769921
60Abnormality of urine glucose concentration (HP:0011016)2.30495365
61Glycosuria (HP:0003076)2.30495365
62Methylmalonic acidemia (HP:0002912)2.19175173
63Vaginal atresia (HP:0000148)2.13898801
64Abnormal biliary tract physiology (HP:0012439)2.13068436
65Bile duct proliferation (HP:0001408)2.13068436
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.11781089
67Emotional lability (HP:0000712)2.11368087
68Anencephaly (HP:0002323)2.10501884
69Genital tract atresia (HP:0001827)2.10385422
70Cerebral hemorrhage (HP:0001342)2.09559441
71Abnormality of serum amino acid levels (HP:0003112)2.08393132
72Short tibia (HP:0005736)2.07192005
73Lethargy (HP:0001254)2.05412322
74Abnormal pupillary function (HP:0007686)2.05238257
75Hyperphosphaturia (HP:0003109)2.02258436
76Retinal dysplasia (HP:0007973)1.99239299
77Renal tubular dysfunction (HP:0000124)1.98521193
78Microvesicular hepatic steatosis (HP:0001414)1.97835270
79Methylmalonic aciduria (HP:0012120)1.97457359
80Meckel diverticulum (HP:0002245)1.96674127
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.95908277
82Abnormal hair whorl (HP:0010721)1.94758282
83Pancytopenia (HP:0001876)1.94565535
84Aplasia/hypoplasia of the uterus (HP:0008684)1.93598603
85Type II lissencephaly (HP:0007260)1.92720290
86Postaxial foot polydactyly (HP:0001830)1.92305054
87Abnormality of the ileum (HP:0001549)1.91500405
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.88293775
89Reduced antithrombin III activity (HP:0001976)1.87978838
90Degeneration of anterior horn cells (HP:0002398)1.85893739
91Abnormality of the anterior horn cell (HP:0006802)1.85893739
92Cerebral hypomyelination (HP:0006808)1.85846308
93Male pseudohermaphroditism (HP:0000037)1.85413917
94Progressive microcephaly (HP:0000253)1.85147388
95Renal cortical cysts (HP:0000803)1.82404601
96Atonic seizures (HP:0010819)1.82139720
97Hypoplastic left heart (HP:0004383)1.79688583
98Cystic liver disease (HP:0006706)1.79182820
99Abnormal rod and cone electroretinograms (HP:0008323)1.78621596
100Tubulointerstitial nephritis (HP:0001970)1.77727688
101Hypoplasia of the uterus (HP:0000013)1.77272792
102Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76892661
103Poor suck (HP:0002033)1.74398450
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73254015
105Preaxial hand polydactyly (HP:0001177)1.72568409
106Occipital encephalocele (HP:0002085)1.72502500
107Focal motor seizures (HP:0011153)1.71961192
108Flared iliac wings (HP:0002869)1.71073303
109Generalized aminoaciduria (HP:0002909)1.70766634
110Congenital hepatic fibrosis (HP:0002612)1.69207460
111Abnormality of the renal medulla (HP:0100957)1.67920525
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.67449569
113Abnormal urine phosphate concentration (HP:0012599)1.66561076
114Congenital ichthyosiform erythroderma (HP:0007431)1.66494365
115Vomiting (HP:0002013)1.65683447
116Pancreatic cysts (HP:0001737)1.65453300
117Cerebral palsy (HP:0100021)1.65362326
118Pancreatic fibrosis (HP:0100732)1.63606122
119Palpitations (HP:0001962)1.63455937
120Abnormal protein glycosylation (HP:0012346)1.62637571
121Abnormal glycosylation (HP:0012345)1.62637571
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62637571
123Abnormal protein N-linked glycosylation (HP:0012347)1.62637571
124True hermaphroditism (HP:0010459)1.62275323
125Patchy hypopigmentation of hair (HP:0011365)1.61264412
126Poor coordination (HP:0002370)1.60965806
127Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58101948
128Dicarboxylic aciduria (HP:0003215)1.58101948
129Sensory axonal neuropathy (HP:0003390)1.56175606
130Gliosis (HP:0002171)1.55306539
131Blindness (HP:0000618)1.54547828
132Hypoplastic heart (HP:0001961)1.52904526
133Myokymia (HP:0002411)1.50074507
134Hepatosplenomegaly (HP:0001433)1.46898886
135Flat capital femoral epiphysis (HP:0003370)1.45545181
136Molar tooth sign on MRI (HP:0002419)1.45289549
137Abnormality of midbrain morphology (HP:0002418)1.45289549
138Spastic paraparesis (HP:0002313)1.45037932
139Neoplasm of the peripheral nervous system (HP:0100007)1.42377705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.66472875
2STK163.48107373
3TNIK3.24259918
4TRIM283.11341206
5MAP4K22.99430993
6MAP3K122.63514361
7CASK2.62895711
8NME12.51084083
9MST42.38502180
10STK392.32447923
11NUAK12.31692268
12ARAF2.20031661
13NME22.11027386
14NEK12.07771306
15TESK22.06322223
16OXSR12.04016441
17MYLK1.99736905
18WNK31.97469578
19CDK191.92880169
20BMPR1B1.91959865
21MUSK1.89540852
22VRK11.87767524
23MAPKAPK51.81172613
24BCKDK1.77722240
25WNK41.75821260
26CDC71.70509702
27ADRBK21.66545560
28BCR1.65014743
29PBK1.62933197
30GRK71.57883220
31MAP2K71.50781255
32PIM21.46534091
33KDR1.46315754
34GRK51.46169619
35SRPK11.40040873
36CDK81.39424970
37BUB11.35712873
38FRK1.30994426
39ERBB31.28442841
40OBSCN1.26384735
41GRK11.21895357
42PLK21.19439524
43PLK11.17450348
44CSNK1G31.16704775
45CSNK1A1L1.15083704
46MAPK131.11135635
47TESK11.10972715
48LIMK11.08836532
49EIF2AK31.07473747
50CCNB11.07164560
51TTK1.06882801
52BRAF1.03754288
53EIF2AK11.03249701
54TAF11.02957592
55CAMK2B1.00651115
56MAP3K131.00018335
57BMPR20.98222517
58TSSK60.95305441
59NTRK30.95262884
60NEK60.94572173
61IRAK40.92355565
62PINK10.91234332
63UHMK10.88696476
64PRPF4B0.88590457
65DYRK30.88420207
66CAMK2D0.88359208
67MAP3K140.84683959
68TIE10.84295910
69PDK20.83780232
70ZAK0.82719854
71TAOK30.80405371
72DYRK20.79005767
73TLK10.78872942
74BRSK20.78505552
75ABL20.77065755
76CAMK2G0.74037135
77ADRBK10.73396677
78MAPK150.73291594
79RPS6KA40.72844997
80DAPK10.72829718
81ATR0.72433045
82CAMK2A0.71352863
83TXK0.70585801
84PKN10.70557282
85PRKCQ0.69376491
86AURKB0.68527901
87TEC0.68079368
88YES10.66198131
89AURKA0.65902504
90CSNK1G20.65847655
91PRKCE0.65160796
92STK240.64632840
93EIF2AK20.64601096
94CSNK1G10.62623444
95MKNK10.62246910
96SCYL20.61038542
97INSRR0.60382902
98MAP3K40.59910533
99RPS6KA50.59009594
100NEK20.58796023
101FLT30.56829699
102PLK40.56147566
103CHEK20.53726891
104CSNK2A10.53494449
105PRKACA0.52393778
106SIK30.52200244
107WEE10.50764219
108PIK3CG0.50638805
109STK38L0.50277235
110PIK3CA0.49229005
111SGK2230.47721913
112SGK4940.47721913
113AKT30.46858423
114PRKCG0.46529949
115SYK0.45339860
116IRAK10.45272132
117PDK30.44844866
118PDK40.44844866
119CSNK2A20.44759937
120LYN0.43183835
121FGR0.42943716
122CDK140.42681131
123BRSK10.42200952
124CDK180.41199108
125WNK10.40449063
126PRKCI0.39864158
127PLK30.39688040
128CSNK1A10.39401115
129MKNK20.39138070
130ACVR1B0.38036045
131IRAK30.37652369
132STK40.37460938
133PRKCD0.36226917
134ATM0.36029578
135EPHA40.35484541
136PHKG10.35307421
137PHKG20.35307421
138ROCK20.35150054
139CDK11A0.34913770
140CDK150.34803973
141GRK60.34613643
142MINK10.32643106
143CAMKK20.31909284
144PNCK0.27717705

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.88786686
2Parkinsons disease_Homo sapiens_hsa050124.99195384
3Protein export_Homo sapiens_hsa030603.74236241
4Alzheimers disease_Homo sapiens_hsa050103.57369986
5Proteasome_Homo sapiens_hsa030503.50708863
6Huntingtons disease_Homo sapiens_hsa050163.30493542
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.01934539
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.92876230
9Ribosome_Homo sapiens_hsa030102.82952779
10Collecting duct acid secretion_Homo sapiens_hsa049662.53281627
11Fatty acid elongation_Homo sapiens_hsa000622.35254454
12Cardiac muscle contraction_Homo sapiens_hsa042602.12101969
13RNA polymerase_Homo sapiens_hsa030202.11292823
14Base excision repair_Homo sapiens_hsa034102.07806707
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02275191
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82791428
17Sulfur metabolism_Homo sapiens_hsa009201.69369573
18Vibrio cholerae infection_Homo sapiens_hsa051101.62780501
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57125288
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49239660
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48985197
22Steroid biosynthesis_Homo sapiens_hsa001001.35523711
23Homologous recombination_Homo sapiens_hsa034401.33910279
24Rheumatoid arthritis_Homo sapiens_hsa053231.31689835
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30137899
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26937632
27RNA transport_Homo sapiens_hsa030131.26055963
28Pyruvate metabolism_Homo sapiens_hsa006201.25991216
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23035167
30One carbon pool by folate_Homo sapiens_hsa006701.22142414
31Pyrimidine metabolism_Homo sapiens_hsa002401.18936034
32Propanoate metabolism_Homo sapiens_hsa006401.14071180
33Synaptic vesicle cycle_Homo sapiens_hsa047211.08269023
34Tryptophan metabolism_Homo sapiens_hsa003801.04546229
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98935810
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98251681
37Metabolic pathways_Homo sapiens_hsa011000.96800719
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.96538705
39Selenocompound metabolism_Homo sapiens_hsa004500.88001401
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85313181
41Caffeine metabolism_Homo sapiens_hsa002320.82876680
42Tyrosine metabolism_Homo sapiens_hsa003500.82417167
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82397408
44Peroxisome_Homo sapiens_hsa041460.81962028
45Ether lipid metabolism_Homo sapiens_hsa005650.79064562
46Purine metabolism_Homo sapiens_hsa002300.77485178
47Nitrogen metabolism_Homo sapiens_hsa009100.76232350
48Regulation of autophagy_Homo sapiens_hsa041400.74531111
49Basal transcription factors_Homo sapiens_hsa030220.73911742
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73762771
51Serotonergic synapse_Homo sapiens_hsa047260.73340202
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73202118
53Nucleotide excision repair_Homo sapiens_hsa034200.72749256
54Glutathione metabolism_Homo sapiens_hsa004800.72436948
55Nicotine addiction_Homo sapiens_hsa050330.72047658
56Phagosome_Homo sapiens_hsa041450.70589016
57Phenylalanine metabolism_Homo sapiens_hsa003600.69700700
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69610072
59Histidine metabolism_Homo sapiens_hsa003400.68099105
60Primary immunodeficiency_Homo sapiens_hsa053400.67388357
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67132463
62Arachidonic acid metabolism_Homo sapiens_hsa005900.65274089
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65055525
64Cell cycle_Homo sapiens_hsa041100.62868916
65Biosynthesis of amino acids_Homo sapiens_hsa012300.61886314
66Non-homologous end-joining_Homo sapiens_hsa034500.60732380
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.58018996
68Butanoate metabolism_Homo sapiens_hsa006500.57239119
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56673373
70Folate biosynthesis_Homo sapiens_hsa007900.56508437
71Allograft rejection_Homo sapiens_hsa053300.55471156
72Type I diabetes mellitus_Homo sapiens_hsa049400.55374396
73Chemical carcinogenesis_Homo sapiens_hsa052040.55202130
74Spliceosome_Homo sapiens_hsa030400.54643474
75Graft-versus-host disease_Homo sapiens_hsa053320.53013459
76Sphingolipid metabolism_Homo sapiens_hsa006000.52887188
77Fatty acid degradation_Homo sapiens_hsa000710.52112102
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52031855
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49210587
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48732351
81Autoimmune thyroid disease_Homo sapiens_hsa053200.47788959
82GABAergic synapse_Homo sapiens_hsa047270.47753239
83RNA degradation_Homo sapiens_hsa030180.47427849
84Oocyte meiosis_Homo sapiens_hsa041140.46485044
85Carbon metabolism_Homo sapiens_hsa012000.46425583
86Linoleic acid metabolism_Homo sapiens_hsa005910.46058746
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45370187
88Taste transduction_Homo sapiens_hsa047420.42395900
89Asthma_Homo sapiens_hsa053100.42235214
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41911383
91Phototransduction_Homo sapiens_hsa047440.41629325
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41167774
93Arginine and proline metabolism_Homo sapiens_hsa003300.40628672
94Systemic lupus erythematosus_Homo sapiens_hsa053220.39947727
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39656838
96p53 signaling pathway_Homo sapiens_hsa041150.39216602
97Retinol metabolism_Homo sapiens_hsa008300.37036951
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.35732487
99Fatty acid metabolism_Homo sapiens_hsa012120.34680652
100DNA replication_Homo sapiens_hsa030300.32317213
101Cocaine addiction_Homo sapiens_hsa050300.31609058
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31127647
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30677235
104Amphetamine addiction_Homo sapiens_hsa050310.29567753
105N-Glycan biosynthesis_Homo sapiens_hsa005100.27945456
106Other glycan degradation_Homo sapiens_hsa005110.27502349
107beta-Alanine metabolism_Homo sapiens_hsa004100.26754128
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25927885
109mRNA surveillance pathway_Homo sapiens_hsa030150.25853099
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25589372
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.25563908
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.24429132
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24339372
114Morphine addiction_Homo sapiens_hsa050320.24328353
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24103224
116Fanconi anemia pathway_Homo sapiens_hsa034600.23780297
117Olfactory transduction_Homo sapiens_hsa047400.23498249
118Dopaminergic synapse_Homo sapiens_hsa047280.22546084
119Mismatch repair_Homo sapiens_hsa034300.21610029
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.19921104
121Pentose phosphate pathway_Homo sapiens_hsa000300.19907274
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18997656
123Sulfur relay system_Homo sapiens_hsa041220.18571190
124Alcoholism_Homo sapiens_hsa050340.18491496
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18325197
126Galactose metabolism_Homo sapiens_hsa000520.16961772
127Lysosome_Homo sapiens_hsa041420.15209507

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