ISCA1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.25926300
2protein neddylation (GO:0045116)4.74641531
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.27298960
4pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.18691981
5cullin deneddylation (GO:0010388)4.14442281
6protein-cofactor linkage (GO:0018065)4.11768724
7pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.01311521
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.93580021
9NADH dehydrogenase complex assembly (GO:0010257)3.93580021
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93580021
11protein deneddylation (GO:0000338)3.88610057
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77531062
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77531062
14protein complex biogenesis (GO:0070271)3.71782266
15rRNA modification (GO:0000154)3.67428140
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62285023
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59767102
18respiratory chain complex IV assembly (GO:0008535)3.57721147
19metallo-sulfur cluster assembly (GO:0031163)3.52035566
20iron-sulfur cluster assembly (GO:0016226)3.52035566
21mitochondrial respiratory chain complex assembly (GO:0033108)3.51291489
22base-excision repair, AP site formation (GO:0006285)3.45174038
23chaperone-mediated protein transport (GO:0072321)3.44393647
24pyrimidine nucleotide catabolic process (GO:0006244)3.42740151
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.42568005
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37954989
27regulation of mitochondrial translation (GO:0070129)3.35254176
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25081680
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.24586438
30termination of RNA polymerase III transcription (GO:0006386)3.24586438
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24264411
32histone mRNA metabolic process (GO:0008334)3.21982455
33protein targeting to mitochondrion (GO:0006626)3.21849445
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21763004
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19405326
36chromatin remodeling at centromere (GO:0031055)3.19301234
37rRNA methylation (GO:0031167)3.17935023
38platelet dense granule organization (GO:0060155)3.14882824
39CENP-A containing nucleosome assembly (GO:0034080)3.14821176
40regulation of cellular amino acid metabolic process (GO:0006521)3.14750165
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13802897
42ATP synthesis coupled proton transport (GO:0015986)3.13802897
43establishment of protein localization to mitochondrion (GO:0072655)3.11958840
44water-soluble vitamin biosynthetic process (GO:0042364)3.10071505
45intracellular protein transmembrane import (GO:0044743)3.08787220
46protein localization to mitochondrion (GO:0070585)3.08730649
47respiratory electron transport chain (GO:0022904)3.06418717
48deoxyribose phosphate biosynthetic process (GO:0046385)3.05278515
492-deoxyribonucleotide biosynthetic process (GO:0009265)3.05278515
50response to pheromone (GO:0019236)3.03568731
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02962230
52organelle disassembly (GO:1903008)3.01577115
53electron transport chain (GO:0022900)3.00589161
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99831411
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99831411
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99831411
57negative regulation of ligase activity (GO:0051352)2.99473928
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99473928
59cytochrome complex assembly (GO:0017004)2.98231805
60mitochondrial RNA metabolic process (GO:0000959)2.97249860
61L-methionine salvage (GO:0071267)2.96939705
62L-methionine biosynthetic process (GO:0071265)2.96939705
63amino acid salvage (GO:0043102)2.96939705
64preassembly of GPI anchor in ER membrane (GO:0016254)2.95686966
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93025835
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93025835
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91677181
68DNA double-strand break processing (GO:0000729)2.91178622
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90491484
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89883855
71ubiquinone biosynthetic process (GO:0006744)2.87286799
72ubiquinone metabolic process (GO:0006743)2.87286186
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.86885081
74mannosylation (GO:0097502)2.86026576
75signal transduction involved in DNA damage checkpoint (GO:0072422)2.83987875
76signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83987875
77deoxyribonucleotide catabolic process (GO:0009264)2.83500054
78branched-chain amino acid catabolic process (GO:0009083)2.82609042
79positive regulation of mitochondrial fission (GO:0090141)2.82135912
80DNA deamination (GO:0045006)2.80257382
81spliceosomal snRNP assembly (GO:0000387)2.78647702
82histone exchange (GO:0043486)2.78394062
83positive regulation of ligase activity (GO:0051351)2.77170534
84deoxyribose phosphate catabolic process (GO:0046386)2.76663381
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76590884
86regulation of mitotic spindle checkpoint (GO:1903504)2.76590884
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.72663759
88telomere maintenance via semi-conservative replication (GO:0032201)2.69697092
892-deoxyribonucleotide metabolic process (GO:0009394)2.69691481
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69604306
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.69604306
92deoxyribonucleotide biosynthetic process (GO:0009263)2.69531165
93oxidative phosphorylation (GO:0006119)2.67264726
94tetrapyrrole biosynthetic process (GO:0033014)2.67053334
95tRNA processing (GO:0008033)2.66693110
96protein K11-linked ubiquitination (GO:0070979)2.66287913
97deoxyribose phosphate metabolic process (GO:0019692)2.65815910
98regulation of cellular respiration (GO:0043457)2.63945972
99porphyrin-containing compound biosynthetic process (GO:0006779)2.63382040
100recombinational repair (GO:0000725)2.62958552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85276185
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54604182
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.79703447
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47413773
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.43936249
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21795636
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.14929209
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08574572
9VDR_23849224_ChIP-Seq_CD4+_Human2.93943711
10IGF1R_20145208_ChIP-Seq_DFB_Human2.72014567
11ZNF274_21170338_ChIP-Seq_K562_Hela2.66798166
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60297699
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59442395
14FOXP3_21729870_ChIP-Seq_TREG_Human2.55075788
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54144096
16ELK1_19687146_ChIP-ChIP_HELA_Human2.53703560
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.50780911
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.50005317
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49118593
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46482342
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29267332
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24377078
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20827813
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20364618
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.17336647
26GABP_19822575_ChIP-Seq_HepG2_Human2.12529084
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05432444
28DCP1A_22483619_ChIP-Seq_HELA_Human2.05270171
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04158007
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88527492
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88495895
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87351881
33E2F7_22180533_ChIP-Seq_HELA_Human1.82522379
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80933705
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71737487
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.69482466
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67119247
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65999238
39EWS_26573619_Chip-Seq_HEK293_Human1.64330038
40VDR_22108803_ChIP-Seq_LS180_Human1.61660649
41MYC_18940864_ChIP-ChIP_HL60_Human1.58456219
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57121301
43IRF1_19129219_ChIP-ChIP_H3396_Human1.51382300
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.47500197
45TAF15_26573619_Chip-Seq_HEK293_Human1.37482326
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36721644
47FUS_26573619_Chip-Seq_HEK293_Human1.35252425
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.35060738
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34783016
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34695770
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34610533
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32318433
53TP53_22573176_ChIP-Seq_HFKS_Human1.31720113
54TTF2_22483619_ChIP-Seq_HELA_Human1.30336444
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27555637
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27359335
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25848541
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25093609
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22292755
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19164753
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16123174
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15361022
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14472520
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12975993
65XRN2_22483619_ChIP-Seq_HELA_Human1.12740055
66KDM5A_27292631_Chip-Seq_BREAST_Human1.12299517
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08102793
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08008666
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03389683
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.01559973
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01544537
72ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99352815
73EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97141186
74TFEB_21752829_ChIP-Seq_HELA_Human0.95975103
75ER_23166858_ChIP-Seq_MCF-7_Human0.95611082
76P300_19829295_ChIP-Seq_ESCs_Human0.94863687
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94798440
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94797908
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.93952448
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.93145372
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93142817
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92596427
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.92268127
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91768195
85GATA1_22025678_ChIP-Seq_K562_Human0.91168019
86AR_20517297_ChIP-Seq_VCAP_Human0.90457155
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88401729
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87360039
89CBP_20019798_ChIP-Seq_JUKART_Human0.87360039
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87061377
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85970771
92NCOR_22424771_ChIP-Seq_293T_Human0.85218275
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85113828
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85062453
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84695974
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84225326
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83783879
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.83783879
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82930496
100* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82588298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.68439100
2MP0008058_abnormal_DNA_repair3.60771107
3MP0003806_abnormal_nucleotide_metabolis3.27476860
4MP0002102_abnormal_ear_morphology3.00285059
5MP0003656_abnormal_erythrocyte_physiolo2.84018025
6MP0006036_abnormal_mitochondrial_physio2.68696566
7MP0009697_abnormal_copulation2.65541970
8MP0010094_abnormal_chromosome_stability2.60997632
9MP0001529_abnormal_vocalization2.42604273
10MP0003186_abnormal_redox_activity2.41890363
11MP0003646_muscle_fatigue2.40107343
12MP0008877_abnormal_DNA_methylation2.35688851
13MP0003718_maternal_effect2.18623902
14MP0003880_abnormal_central_pattern2.15531615
15MP0000372_irregular_coat_pigmentation2.12955609
16MP0004957_abnormal_blastocyst_morpholog2.06232531
17MP0001764_abnormal_homeostasis2.05875468
18MP0002138_abnormal_hepatobiliary_system2.00823352
19MP0006035_abnormal_mitochondrial_morpho1.98331316
20MP0003693_abnormal_embryo_hatching1.98268679
21MP0006276_abnormal_autonomic_nervous1.87486742
22MP0005084_abnormal_gallbladder_morpholo1.83357091
23MP0008872_abnormal_physiological_respon1.82772180
24MP0003011_delayed_dark_adaptation1.82347369
25MP0009046_muscle_twitch1.80196283
26MP0002139_abnormal_hepatobiliary_system1.79593826
27MP0008057_abnormal_DNA_replication1.78558215
28MP0003111_abnormal_nucleus_morphology1.77913125
29MP0006292_abnormal_olfactory_placode1.76708414
30MP0008260_abnormal_autophagy1.73787824
31MP0005410_abnormal_fertilization1.70014580
32MP0003786_premature_aging1.63945568
33MP0008789_abnormal_olfactory_epithelium1.56054956
34MP0005083_abnormal_biliary_tract1.55809672
35MP0005646_abnormal_pituitary_gland1.55336506
36MP0006072_abnormal_retinal_apoptosis1.53814662
37MP0005075_abnormal_melanosome_morpholog1.46292527
38MP0005645_abnormal_hypothalamus_physiol1.46137001
39MP0002837_dystrophic_cardiac_calcinosis1.45746096
40MP0004215_abnormal_myocardial_fiber1.43286982
41MP0002736_abnormal_nociception_after1.37395763
42MP0009764_decreased_sensitivity_to1.37263975
43MP0005253_abnormal_eye_physiology1.31807490
44MP0002090_abnormal_vision1.29930324
45MP0004133_heterotaxia1.29873837
46MP0000358_abnormal_cell_content/1.29494187
47MP0005551_abnormal_eye_electrophysiolog1.26326242
48MP0003077_abnormal_cell_cycle1.24581668
49MP0004142_abnormal_muscle_tone1.21731689
50MP0008995_early_reproductive_senescence1.20035001
51MP0005174_abnormal_tail_pigmentation1.19172567
52MP0008932_abnormal_embryonic_tissue1.18192175
53MP0004145_abnormal_muscle_electrophysio1.17794564
54MP0001905_abnormal_dopamine_level1.14477429
55MP0008875_abnormal_xenobiotic_pharmacok1.14024271
56MP0001929_abnormal_gametogenesis1.11078235
57MP0005636_abnormal_mineral_homeostasis1.09142410
58MP0003121_genomic_imprinting1.09041731
59MP0005397_hematopoietic_system_phenotyp1.07831229
60MP0001545_abnormal_hematopoietic_system1.07831229
61MP0005332_abnormal_amino_acid1.05045828
62MP0002210_abnormal_sex_determination1.04903776
63MP0002822_catalepsy1.04443644
64MP0006054_spinal_hemorrhage1.02496664
65MP0003698_abnormal_male_reproductive1.00931448
66MP0002254_reproductive_system_inflammat1.00153012
67MP0005647_abnormal_sex_gland0.98862109
68MP0003787_abnormal_imprinting0.96326123
69MP0000015_abnormal_ear_pigmentation0.95723270
70MP0000653_abnormal_sex_gland0.95614355
71MP0000749_muscle_degeneration0.94746060
72MP0000631_abnormal_neuroendocrine_gland0.93006110
73MP0001986_abnormal_taste_sensitivity0.91876634
74MP0005266_abnormal_metabolism0.90001305
75MP0002332_abnormal_exercise_endurance0.85895270
76MP0003195_calcinosis0.82693636
77MP0008007_abnormal_cellular_replicative0.82628576
78MP0001293_anophthalmia0.80144416
79MP0001145_abnormal_male_reproductive0.80045809
80MP0005394_taste/olfaction_phenotype0.79660729
81MP0005499_abnormal_olfactory_system0.79660729
82MP0001324_abnormal_eye_pigmentation0.79528605
83MP0002272_abnormal_nervous_system0.79343991
84MP0002234_abnormal_pharynx_morphology0.79132077
85MP0004782_abnormal_surfactant_physiolog0.79042702
86MP0002876_abnormal_thyroid_physiology0.75777039
87MP0000230_abnormal_systemic_arterial0.75745404
88MP0008775_abnormal_heart_ventricle0.74975611
89MP0005395_other_phenotype0.74887532
90MP0000639_abnormal_adrenal_gland0.73723401
91MP0001968_abnormal_touch/_nociception0.73552407
92MP0005408_hypopigmentation0.72750186
93MP0000516_abnormal_urinary_system0.72439010
94MP0005367_renal/urinary_system_phenotyp0.72439010
95MP0001119_abnormal_female_reproductive0.72071518
96MP0003567_abnormal_fetal_cardiomyocyte0.71411856
97MP0005319_abnormal_enzyme/_coenzyme0.70023128
98MP0005464_abnormal_platelet_physiology0.67179706
99MP0002095_abnormal_skin_pigmentation0.66509909
100MP0003221_abnormal_cardiomyocyte_apopto0.66242265

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.62636374
2Acute encephalopathy (HP:0006846)4.28084499
3Abnormal mitochondria in muscle tissue (HP:0008316)4.26602365
4Progressive macrocephaly (HP:0004481)3.80050544
5Mitochondrial inheritance (HP:0001427)3.78513992
63-Methylglutaconic aciduria (HP:0003535)3.75986755
7Increased CSF lactate (HP:0002490)3.64884405
8Hepatocellular necrosis (HP:0001404)3.57422557
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.45070223
10Methylmalonic aciduria (HP:0012120)3.43025584
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31089982
12Abnormality of alanine metabolism (HP:0010916)3.31089982
13Hyperalaninemia (HP:0003348)3.31089982
14Hepatic necrosis (HP:0002605)3.30831294
15Cerebral edema (HP:0002181)3.27693835
16Increased serum lactate (HP:0002151)3.10961160
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09541743
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09541743
19Lactic acidosis (HP:0003128)3.02978463
20Delayed CNS myelination (HP:0002188)2.97119250
21Type I transferrin isoform profile (HP:0003642)2.87926567
22Progressive inability to walk (HP:0002505)2.74651642
23Methylmalonic acidemia (HP:0002912)2.68438527
24Reduced antithrombin III activity (HP:0001976)2.66032091
25Exercise intolerance (HP:0003546)2.61379094
26Increased serum pyruvate (HP:0003542)2.56189971
27Respiratory failure (HP:0002878)2.46585501
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45137354
29Abnormal protein N-linked glycosylation (HP:0012347)2.45137354
30Abnormal protein glycosylation (HP:0012346)2.45137354
31Abnormal glycosylation (HP:0012345)2.45137354
32Degeneration of anterior horn cells (HP:0002398)2.41982717
33Abnormality of the anterior horn cell (HP:0006802)2.41982717
34Lipid accumulation in hepatocytes (HP:0006561)2.38065189
35Increased hepatocellular lipid droplets (HP:0006565)2.37202633
36Hyperglycinemia (HP:0002154)2.37190325
37Microvesicular hepatic steatosis (HP:0001414)2.36961371
38Poikilocytosis (HP:0004447)2.36746991
39Paralysis (HP:0003470)2.36493636
40Lethargy (HP:0001254)2.32092629
41Cerebral hypomyelination (HP:0006808)2.31878315
42Renal Fanconi syndrome (HP:0001994)2.30937899
43Increased intramyocellular lipid droplets (HP:0012240)2.28877881
44Dyschromatopsia (HP:0007641)2.24827027
45Inability to walk (HP:0002540)2.16235980
46Dicarboxylic aciduria (HP:0003215)2.15618317
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15618317
48Hypochromic microcytic anemia (HP:0004840)2.13313268
49Severe visual impairment (HP:0001141)2.13100630
50Thyroid-stimulating hormone excess (HP:0002925)2.12244769
51Optic disc pallor (HP:0000543)2.12226064
52Nephronophthisis (HP:0000090)2.06082619
53Aplasia/hypoplasia of the uterus (HP:0008684)2.05953262
54Abnormality of glycolysis (HP:0004366)2.05264352
55Exercise-induced muscle cramps (HP:0003710)2.03041468
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02177513
57CNS demyelination (HP:0007305)1.99467615
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99378487
59Meckel diverticulum (HP:0002245)1.98307901
60Leukodystrophy (HP:0002415)1.97909285
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.94347024
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93385942
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92260565
64Pancreatic cysts (HP:0001737)1.92031861
65Abnormality of the pons (HP:0007361)1.91565107
66Increased muscle lipid content (HP:0009058)1.90770387
67Generalized aminoaciduria (HP:0002909)1.89811916
68Abnormality of serum amino acid levels (HP:0003112)1.88675499
69Abnormality of the ileum (HP:0001549)1.87741537
70Postnatal microcephaly (HP:0005484)1.85548988
71Gout (HP:0001997)1.85336016
72Tubulointerstitial nephritis (HP:0001970)1.84716346
73Atrophy/Degeneration involving motor neurons (HP:0007373)1.84493909
74Emotional lability (HP:0000712)1.84113567
75Hypoplasia of the fovea (HP:0007750)1.84062116
76Aplasia/Hypoplasia of the fovea (HP:0008060)1.84062116
77Abnormal number of erythroid precursors (HP:0012131)1.83398399
78Hypoplasia of the pons (HP:0012110)1.83203809
79Fibular aplasia (HP:0002990)1.82462168
80Delayed myelination (HP:0012448)1.82181342
81X-linked dominant inheritance (HP:0001423)1.81093520
82Nemaline bodies (HP:0003798)1.81040681
83Abolished electroretinogram (ERG) (HP:0000550)1.80838961
84Abnormality of the fovea (HP:0000493)1.80757041
85Abnormal gallbladder morphology (HP:0012437)1.78816618
86Hypoplasia of the uterus (HP:0000013)1.78245675
87Decreased central vision (HP:0007663)1.76499566
88Cholelithiasis (HP:0001081)1.76481062
89Metabolic acidosis (HP:0001942)1.72268390
90Chromsome breakage (HP:0040012)1.71977503
91Dyskinesia (HP:0100660)1.70984457
92Muscle fiber inclusion bodies (HP:0100299)1.69464046
93Glycosuria (HP:0003076)1.69309145
94Abnormality of urine glucose concentration (HP:0011016)1.69309145
95Ketosis (HP:0001946)1.68790470
96Type 2 muscle fiber atrophy (HP:0003554)1.68065048
97Short tibia (HP:0005736)1.66968605
98Aplastic anemia (HP:0001915)1.66914119
99Abnormality of the preputium (HP:0100587)1.66409333
100Type II lissencephaly (HP:0007260)1.66255922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.20932353
2EIF2AK13.17218522
3MST42.95185945
4VRK22.68852862
5ZAK2.61422584
6WNK32.48173244
7PLK42.37171820
8BCR2.29117115
9PBK2.17408881
10BCKDK2.12408598
11STK161.96971524
12VRK11.93077751
13PLK31.92776972
14MAP4K21.90783623
15SRPK11.88053356
16NEK11.72695196
17BUB11.71273822
18CDC71.67053972
19EIF2AK31.66537227
20MUSK1.64928831
21CSNK1G31.59091849
22TXK1.53117456
23BRSK21.48483180
24SIK31.44281398
25DYRK31.43754079
26GRK11.42895891
27OBSCN1.35405600
28PLK21.34670435
29PHKG21.31418348
30PHKG11.31418348
31DYRK21.30712188
32TESK11.30075358
33MAP2K71.29327018
34CSNK1G11.26664629
35CSNK1G21.23590019
36CCNB11.21107799
37PLK11.20997914
38ERBB31.20768777
39MAP3K121.20489625
40NME11.18960733
41CSNK1A1L1.17668448
42NUAK11.17336008
43NME21.13790695
44CDK191.05682404
45PRKD31.05038409
46MAPK130.94488608
47EPHA30.93710223
48PIM20.90382119
49MKNK10.89744440
50WNK40.89713915
51CAMKK20.89225263
52PINK10.88247589
53WEE10.87004536
54RPS6KA50.86886796
55TESK20.86669692
56TSSK60.85530300
57LIMK10.81939146
58MAP3K50.79728136
59ADRBK20.77970279
60MAP3K40.77411040
61TTK0.76721614
62TAOK30.76453384
63GRK60.74869513
64PDK20.73481957
65IRAK10.72261120
66FRK0.69760212
67STK390.66802582
68ACVR1B0.64255872
69IKBKB0.61322850
70CHEK20.60279600
71BRSK10.58797880
72TLK10.57270133
73ATR0.57125101
74CSNK2A10.55460216
75RPS6KA40.55246419
76MINK10.53028158
77AURKB0.52264516
78EIF2AK20.51370327
79SCYL20.50688193
80PRKCE0.50463653
81CLK10.48787175
82CSNK2A20.47686363
83CSNK1A10.47041076
84PRKCI0.46256256
85CAMK2D0.45699782
86MYLK0.44023131
87FLT30.42552011
88INSRR0.42271068
89ATM0.40765559
90KDR0.39448000
91AURKA0.39073881
92ABL20.36620098
93BMPR1B0.35525723
94PIM10.32452891
95TIE10.31365798
96PTK2B0.31309381
97TEC0.30954049
98DAPK10.29695021
99PNCK0.29572227
100ADRBK10.29269715

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19499590
2Protein export_Homo sapiens_hsa030603.72511568
3Oxidative phosphorylation_Homo sapiens_hsa001903.01931239
4Parkinsons disease_Homo sapiens_hsa050122.75566612
5Mismatch repair_Homo sapiens_hsa034302.57718207
6RNA polymerase_Homo sapiens_hsa030202.47898277
7DNA replication_Homo sapiens_hsa030302.36273988
8Base excision repair_Homo sapiens_hsa034102.30108019
9Homologous recombination_Homo sapiens_hsa034402.17269115
10Fanconi anemia pathway_Homo sapiens_hsa034602.16260742
11Regulation of autophagy_Homo sapiens_hsa041402.05909394
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03303601
13Propanoate metabolism_Homo sapiens_hsa006401.99557525
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98433073
15Basal transcription factors_Homo sapiens_hsa030221.94217681
16Pyrimidine metabolism_Homo sapiens_hsa002401.90992609
17Huntingtons disease_Homo sapiens_hsa050161.84343635
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81950276
19Nucleotide excision repair_Homo sapiens_hsa034201.80015350
20Non-homologous end-joining_Homo sapiens_hsa034501.70864354
21Fatty acid elongation_Homo sapiens_hsa000621.64558671
22RNA degradation_Homo sapiens_hsa030181.62753599
23Spliceosome_Homo sapiens_hsa030401.62611105
24Alzheimers disease_Homo sapiens_hsa050101.58040650
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58010832
26RNA transport_Homo sapiens_hsa030131.55046272
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47036833
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45115586
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43126706
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41266367
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39562489
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36384394
33One carbon pool by folate_Homo sapiens_hsa006701.34608150
34Ribosome_Homo sapiens_hsa030101.33430926
35Purine metabolism_Homo sapiens_hsa002301.32173218
36Phototransduction_Homo sapiens_hsa047441.30529184
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29056841
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.27833173
39Folate biosynthesis_Homo sapiens_hsa007901.26962633
40Nitrogen metabolism_Homo sapiens_hsa009101.25100648
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22020148
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18370514
43Sulfur metabolism_Homo sapiens_hsa009201.15847820
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13487865
45Selenocompound metabolism_Homo sapiens_hsa004501.08814190
46Steroid biosynthesis_Homo sapiens_hsa001001.07027989
47Peroxisome_Homo sapiens_hsa041461.05702100
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05463273
49Collecting duct acid secretion_Homo sapiens_hsa049661.02368243
50Butanoate metabolism_Homo sapiens_hsa006501.00239959
51Cardiac muscle contraction_Homo sapiens_hsa042600.99085628
52Pyruvate metabolism_Homo sapiens_hsa006200.97258896
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.95200259
54Glutathione metabolism_Homo sapiens_hsa004800.94983485
55p53 signaling pathway_Homo sapiens_hsa041150.94080064
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91382633
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85316256
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85169069
59Carbon metabolism_Homo sapiens_hsa012000.85091802
60Sulfur relay system_Homo sapiens_hsa041220.83923964
61Cell cycle_Homo sapiens_hsa041100.82946684
62Metabolic pathways_Homo sapiens_hsa011000.82287901
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66761291
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.66237664
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65990313
66Oocyte meiosis_Homo sapiens_hsa041140.65329865
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65064891
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64611942
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62280045
70Biosynthesis of amino acids_Homo sapiens_hsa012300.61030990
71Chemical carcinogenesis_Homo sapiens_hsa052040.57757387
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54939633
73mRNA surveillance pathway_Homo sapiens_hsa030150.53177098
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50344711
75Olfactory transduction_Homo sapiens_hsa047400.47894754
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46251686
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.43102528
78beta-Alanine metabolism_Homo sapiens_hsa004100.42944920
79Circadian rhythm_Homo sapiens_hsa047100.42728866
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42571338
81Fatty acid metabolism_Homo sapiens_hsa012120.42505443
82Pentose phosphate pathway_Homo sapiens_hsa000300.40819097
83Tryptophan metabolism_Homo sapiens_hsa003800.39638788
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37541908
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34227570
86Linoleic acid metabolism_Homo sapiens_hsa005910.34164716
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33833016
88N-Glycan biosynthesis_Homo sapiens_hsa005100.33512336
89Retinol metabolism_Homo sapiens_hsa008300.32443675
90Arachidonic acid metabolism_Homo sapiens_hsa005900.32048637
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31668072
92Ether lipid metabolism_Homo sapiens_hsa005650.31152858
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30842288
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28514550
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27416638
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26668821
97Phenylalanine metabolism_Homo sapiens_hsa003600.25484208
98Fatty acid degradation_Homo sapiens_hsa000710.24845459
99Epstein-Barr virus infection_Homo sapiens_hsa051690.22776870
100Starch and sucrose metabolism_Homo sapiens_hsa005000.22406299

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