IRX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)7.80203182
2pyrimidine nucleobase catabolic process (GO:0006208)7.10378306
3low-density lipoprotein particle clearance (GO:0034383)6.92880095
4regulation of somitogenesis (GO:0014807)6.41698339
5triglyceride catabolic process (GO:0019433)6.30399981
6regulation of sequestering of triglyceride (GO:0010889)5.98118951
7negative regulation of axon guidance (GO:1902668)5.71161134
8regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.55397336
9neutral lipid catabolic process (GO:0046461)5.52381022
10acylglycerol catabolic process (GO:0046464)5.52381022
11synaptic vesicle maturation (GO:0016188)5.45518196
12protein-chromophore linkage (GO:0018298)5.39481534
13nucleobase catabolic process (GO:0046113)5.25643258
14cell migration in hindbrain (GO:0021535)5.05331676
15midbrain development (GO:0030901)4.91728422
16melanin biosynthetic process (GO:0042438)4.81494609
17negative regulation of leukocyte chemotaxis (GO:0002689)4.79204612
18muscle cell fate commitment (GO:0042693)4.78968550
19acrosome reaction (GO:0007340)4.76582736
20neuron projection extension involved in neuron projection guidance (GO:1902284)4.66451277
21axon extension involved in axon guidance (GO:0048846)4.66451277
22regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61148285
23positive regulation of uterine smooth muscle contraction (GO:0070474)4.56746570
24NADH metabolic process (GO:0006734)4.52108448
25melanin metabolic process (GO:0006582)4.46407577
26cellular response to epinephrine stimulus (GO:0071872)4.42298483
27retinal rod cell development (GO:0046548)4.24916321
28response to dietary excess (GO:0002021)4.21249082
29somite rostral/caudal axis specification (GO:0032525)4.16942887
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16507843
31regulation of chemokine-mediated signaling pathway (GO:0070099)4.16291445
32regulation of glycogen (starch) synthase activity (GO:2000465)4.15294495
33detection of temperature stimulus (GO:0016048)4.07625724
34barbed-end actin filament capping (GO:0051016)4.04700792
35secondary metabolite biosynthetic process (GO:0044550)4.03811537
36detection of light stimulus involved in sensory perception (GO:0050962)4.03226054
37detection of light stimulus involved in visual perception (GO:0050908)4.03226054
38transcytosis (GO:0045056)4.02088038
39regulation of secondary heart field cardioblast proliferation (GO:0003266)3.99948470
40regulation of cardioblast proliferation (GO:0003264)3.99948470
41response to epinephrine (GO:0071871)3.98488180
42regulation of axon guidance (GO:1902667)3.96588322
43lymph vessel development (GO:0001945)3.91103854
44receptor recycling (GO:0001881)3.90796994
45fatty acid homeostasis (GO:0055089)3.87359320
46maintenance of protein location in nucleus (GO:0051457)3.82454605
47regulation of telomere maintenance via telomerase (GO:0032210)3.81807313
48negative regulation of catenin import into nucleus (GO:0035414)3.81611530
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.80395561
50membrane hyperpolarization (GO:0060081)3.78270482
51positive regulation of glomerulus development (GO:0090193)3.77876881
52protein localization to synapse (GO:0035418)3.70001339
53glycerolipid catabolic process (GO:0046503)3.68992285
54outflow tract septum morphogenesis (GO:0003148)3.65465198
55CDP-diacylglycerol biosynthetic process (GO:0016024)3.62565508
56CDP-diacylglycerol metabolic process (GO:0046341)3.61255201
57regulation of uterine smooth muscle contraction (GO:0070472)3.60870825
58ovulation from ovarian follicle (GO:0001542)3.57055674
59negative regulation of granulocyte differentiation (GO:0030853)3.53529423
60fusion of sperm to egg plasma membrane (GO:0007342)3.52924792
61negative regulation of dendrite development (GO:2000171)3.51019493
62polyol transport (GO:0015791)3.48597888
63outer ear morphogenesis (GO:0042473)3.48111214
64adult feeding behavior (GO:0008343)3.46397704
65regulation of synapse structural plasticity (GO:0051823)3.45876052
66sperm motility (GO:0030317)3.45362205
67synaptic vesicle endocytosis (GO:0048488)3.43329766
68central nervous system projection neuron axonogenesis (GO:0021952)3.38740450
69positive regulation of protein kinase C signaling (GO:0090037)3.38368738
70protein heterotrimerization (GO:0070208)3.34905137
71lipid storage (GO:0019915)3.32539535
72sperm capacitation (GO:0048240)3.31688098
73positive regulation of lipid storage (GO:0010884)3.31684030
74retinal ganglion cell axon guidance (GO:0031290)3.29641547
75rhodopsin mediated signaling pathway (GO:0016056)3.26702616
76negative regulation of epidermis development (GO:0045683)3.26532483
77regulation of dopamine secretion (GO:0014059)3.25008895
78regulation of dopamine metabolic process (GO:0042053)3.24271462
79regulation of catecholamine metabolic process (GO:0042069)3.24271462
80response to auditory stimulus (GO:0010996)3.20865416
81negative regulation of axon extension (GO:0030517)3.19751967
82regulation of cholesterol storage (GO:0010885)3.19422333
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.19189255
84tooth mineralization (GO:0034505)3.18385958
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17783899
86negative regulation of axon extension involved in axon guidance (GO:0048843)3.17137858
87regulation of lipoprotein metabolic process (GO:0050746)3.15757959
88negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.15157119
89detection of light stimulus (GO:0009583)3.11502266
90DNA damage response, detection of DNA damage (GO:0042769)3.10302961
91cGMP-mediated signaling (GO:0019934)3.10040162
92nucleosome disassembly (GO:0006337)3.09901293
93protein-DNA complex disassembly (GO:0032986)3.09901293
94cardiac myofibril assembly (GO:0055003)3.09807670
95regulation of rhodopsin mediated signaling pathway (GO:0022400)3.09339660
96hyperosmotic salinity response (GO:0042538)3.08184266
97cranial nerve morphogenesis (GO:0021602)3.08053173
98negative regulation of microtubule polymerization (GO:0031115)3.07310894
99regulation of ruffle assembly (GO:1900027)3.07168507
100synaptic transmission, glutamatergic (GO:0035249)3.07112925
101positive regulation of myotube differentiation (GO:0010831)3.06873372
102negative chemotaxis (GO:0050919)3.06136775
103chromosome condensation (GO:0030261)3.05858937
104fatty acid beta-oxidation (GO:0006635)3.03915009
105heart contraction (GO:0060047)3.03628280
106heart process (GO:0003015)3.03628280
107triglyceride biosynthetic process (GO:0019432)3.03412052
108regulation of apoptotic process involved in morphogenesis (GO:1902337)3.03017128
109auditory behavior (GO:0031223)3.02780121
110cell fate commitment involved in formation of primary germ layer (GO:0060795)3.02183807
111negative regulation of metanephros development (GO:0072217)2.99562649
112white fat cell differentiation (GO:0050872)2.98693616
113negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.97544058
114left/right axis specification (GO:0070986)2.97251340
115embryonic viscerocranium morphogenesis (GO:0048703)2.96624213
116lipid particle organization (GO:0034389)2.96423355
117photoreceptor cell maintenance (GO:0045494)2.96284910
118chaperone-mediated protein transport (GO:0072321)2.95105261
119fatty acid catabolic process (GO:0009062)2.94982263
120diacylglycerol metabolic process (GO:0046339)2.94689877
121negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.94588114
122mitotic G1 DNA damage checkpoint (GO:0031571)2.94265638
123phototransduction (GO:0007602)2.93717512
124positive regulation of lipoprotein lipase activity (GO:0051006)2.92506104
125positive regulation of triglyceride lipase activity (GO:0061365)2.92506104
126regulation of cardioblast differentiation (GO:0051890)2.91782957
127negative regulation of axonogenesis (GO:0050771)2.91396617
128fatty acid transmembrane transport (GO:1902001)2.88935734
129DNA packaging (GO:0006323)2.88795322
130coronary vasculature morphogenesis (GO:0060977)2.88723759
131ketone body metabolic process (GO:1902224)2.88554372
132brown fat cell differentiation (GO:0050873)2.88489245
133positive regulation of cellular response to insulin stimulus (GO:1900078)2.86364245
134motor neuron axon guidance (GO:0008045)2.85842212
135vocalization behavior (GO:0071625)2.85217261
136amyloid precursor protein catabolic process (GO:0042987)2.85083077
137acylglycerol biosynthetic process (GO:0046463)2.84319554
138neutral lipid biosynthetic process (GO:0046460)2.84319554
139muscle organ morphogenesis (GO:0048644)2.84262307
140metanephric nephron epithelium development (GO:0072243)2.84201556
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83289753
142ethanol oxidation (GO:0006069)2.83154257
143creatine metabolic process (GO:0006600)2.82548481
144rRNA transcription (GO:0009303)2.81733437
145calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81582278
146negative regulation of cartilage development (GO:0061037)2.81547220
147negative regulation of smooth muscle cell proliferation (GO:0048662)2.81250400
148striatum development (GO:0021756)2.80966945
149sexual reproduction (GO:0019953)2.80545755
150cellular ketone body metabolic process (GO:0046950)2.80446264
151regulation of gonadotropin secretion (GO:0032276)2.79321751
152photoreceptor cell development (GO:0042461)2.78337190
153ventricular system development (GO:0021591)2.77596968
154detection of temperature stimulus involved in sensory perception (GO:0050961)2.77306658
155detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.77306658
156regulation of protein kinase A signaling (GO:0010738)2.76139136
157mating behavior (GO:0007617)2.76061427
158histone H4-K5 acetylation (GO:0043981)2.74995309
159histone H4-K8 acetylation (GO:0043982)2.74995309
160axon extension (GO:0048675)2.74214600
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74180710
162regulation of respiratory system process (GO:0044065)2.74002286
163metanephric nephron tubule development (GO:0072234)2.73030742
164metanephric tubule development (GO:0072170)2.73030742
165regulation of cilium movement (GO:0003352)2.72908315
166regulation of triglyceride biosynthetic process (GO:0010866)2.72026679
167negative regulation of amino acid transport (GO:0051956)2.71689765
168facial nerve structural organization (GO:0021612)2.71137560
169potassium ion export (GO:0071435)2.70753481
170layer formation in cerebral cortex (GO:0021819)2.70602602
171coenzyme catabolic process (GO:0009109)2.70426444
172lateral ventricle development (GO:0021670)2.70021075
173positive regulation of glycolytic process (GO:0045821)2.69739643
174photoreceptor cell differentiation (GO:0046530)2.68326648
175eye photoreceptor cell differentiation (GO:0001754)2.68326648
176spermatid nucleus differentiation (GO:0007289)2.67624621
177cardiovascular system development (GO:0072358)2.66549742
178eye photoreceptor cell development (GO:0042462)2.66340853
179plasma membrane fusion (GO:0045026)2.66155489
180negative regulation of smooth muscle cell migration (GO:0014912)2.65996784
181detection of visible light (GO:0009584)2.65261150
182regulation of fatty acid oxidation (GO:0046320)2.64892054
183regulation of macrophage derived foam cell differentiation (GO:0010743)2.64107367
184regulation of extent of cell growth (GO:0061387)2.63125859
185biotin metabolic process (GO:0006768)2.62807481
186G1 DNA damage checkpoint (GO:0044783)2.62784817
187cell migration involved in heart development (GO:0060973)2.62641491
188cardiac muscle contraction (GO:0060048)2.62026555
189mitochondrion distribution (GO:0048311)2.60872375
190neuron-neuron synaptic transmission (GO:0007270)2.60617553
191behavioral defense response (GO:0002209)2.59304024
192behavioral fear response (GO:0001662)2.59304024
193regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58953640
194synaptic vesicle exocytosis (GO:0016079)2.58540797
195detection of external stimulus (GO:0009581)2.58528830
196glutamate secretion (GO:0014047)2.57925555
197daunorubicin metabolic process (GO:0044597)2.56980175
198doxorubicin metabolic process (GO:0044598)2.56980175
199response to pheromone (GO:0019236)11.7476177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.63177081
2EZH2_22144423_ChIP-Seq_EOC_Human4.38299522
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.96866984
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.83282741
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.83282741
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.83282741
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.52105182
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.11706837
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.90893819
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82221155
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82221155
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77805525
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71071508
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70797505
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70644553
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.70641381
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.63386063
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53835152
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.52652977
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46416126
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.45767141
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.44155146
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39247760
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38819285
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.37848486
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.30376624
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29727162
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.26905410
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26589267
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.12770971
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05275659
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04287950
33P68_20966046_ChIP-Seq_HELA_Human2.03637069
34TP53_20018659_ChIP-ChIP_R1E_Mouse2.03635325
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02071827
36ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01572031
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01111794
38RNF2_27304074_Chip-Seq_NSC_Mouse1.99655300
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97631953
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96443164
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.90403826
42REST_21632747_ChIP-Seq_MESCs_Mouse1.88901200
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.88669787
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.88566780
45* TP63_19390658_ChIP-ChIP_HaCaT_Human1.85857845
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85370887
47* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85039464
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.79408210
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.78521920
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.74794742
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.74794742
52SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.73954431
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73361919
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72930506
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69356507
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69291261
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66928739
58* SA1_27219007_Chip-Seq_ERYTHROID_Human1.66906743
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.66097212
60GBX2_23144817_ChIP-Seq_PC3_Human1.65947072
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65102072
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.61733555
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61038923
64BCL6_27268052_Chip-Seq_Bcells_Human1.58685504
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58364222
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.57467828
67SA1_27219007_Chip-Seq_Bcells_Human1.57196171
68RACK7_27058665_Chip-Seq_MCF-7_Human1.56881341
69IGF1R_20145208_ChIP-Seq_DFB_Human1.56678293
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56285800
71* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50978742
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50623301
73TP63_22573176_ChIP-Seq_HFKS_Human1.48170550
74E2F1_20622854_ChIP-Seq_HELA_Human1.47610119
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47457926
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.46360283
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.45699509
78DROSHA_22980978_ChIP-Seq_HELA_Human1.45361872
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44687817
80CTCF_20526341_ChIP-Seq_ESCs_Human1.44364078
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.43258160
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41385602
83BCOR_27268052_Chip-Seq_Bcells_Human1.40428016
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38599172
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37540413
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37339132
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36963228
88PHF8_20622854_ChIP-Seq_HELA_Human1.36961621
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36508698
90ERA_21632823_ChIP-Seq_H3396_Human1.36505590
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.35958314
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.34522538
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33002687
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.31922198
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31879154
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26741100
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26335828
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25904208
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25411056
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24341357
101CTCF_21964334_Chip-Seq_Bcells_Human1.24341327
102CTCF_27219007_Chip-Seq_Bcells_Human1.24289140
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22023677
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21646028
105KDM2B_26808549_Chip-Seq_K562_Human1.20815424
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19137498
107SOX3_22085726_ChIP-Seq_NPCs_Mouse1.18463368
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14842379
109KDM2B_26808549_Chip-Seq_DND41_Human1.14540619
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14152678
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13747371
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13623338
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12875412
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12396513
115RAC3_21632823_ChIP-Seq_H3396_Human1.12248138
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11559930
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11025257
118IRF1_19129219_ChIP-ChIP_H3396_Human1.10807641
119LXR_22292898_ChIP-Seq_THP-1_Human1.10692171
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07413893
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07009644
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06733242
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05734098
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.05203043
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04169327
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04085668
127SMC4_20622854_ChIP-Seq_HELA_Human1.02789200
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02123852
129TP53_23651856_ChIP-Seq_MEFs_Mouse1.01928097
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.00258203
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99703246
132SPI1_20517297_ChIP-Seq_HL60_Human0.99513169
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99476108
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98370623
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98305210
136ETS1_21867929_ChIP-Seq_TH2_Mouse0.98194571
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.96890242
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96240252
139CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96112538
140* AR_19668381_ChIP-Seq_PC3_Human0.95325800
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94426824
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93304228
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91156221
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90784449
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89614279
146GATA1_26923725_Chip-Seq_HPCs_Mouse0.88561664
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88230980
148OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87119438
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85009760
150RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84961377
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84551789
152POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84374469
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84282379
154PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83999691
155CDX2_20551321_ChIP-Seq_CACO-2_Human0.82388655
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82341375
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81831488
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81600223
159NANOG_18692474_ChIP-Seq_MESCs_Mouse0.80499926
160* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80037475
161TET1_21490601_ChIP-Seq_MESCs_Mouse0.77985103
162TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77642147
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77525552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.68097834
2MP0003011_delayed_dark_adaptation4.98846984
3MP0005666_abnormal_adipose_tissue4.43571282
4MP0010030_abnormal_orbit_morphology4.19599724
5MP0005375_adipose_tissue_phenotype3.51997728
6MP0004130_abnormal_muscle_cell3.37172729
7MP0005551_abnormal_eye_electrophysiolog3.32734607
8MP0001486_abnormal_startle_reflex3.25682045
9MP0006292_abnormal_olfactory_placode3.12487916
10MP0003122_maternal_imprinting2.83530556
11MP0004270_analgesia2.73659827
12MP0000751_myopathy2.73199247
13MP0005171_absent_coat_pigmentation2.72995836
14MP0000003_abnormal_adipose_tissue2.63618012
15MP0002971_abnormal_brown_adipose2.62127055
16MP0005253_abnormal_eye_physiology2.58158491
17MP0006138_congestive_heart_failure2.57084613
18MP0004858_abnormal_nervous_system2.56246257
19MP0004084_abnormal_cardiac_muscle2.53318571
20MP0006072_abnormal_retinal_apoptosis2.52855957
21MP0006276_abnormal_autonomic_nervous2.51209347
22MP0003136_yellow_coat_color2.48253358
23MP0003890_abnormal_embryonic-extraembry2.47493042
24MP0004859_abnormal_synaptic_plasticity2.36810792
25MP0002735_abnormal_chemical_nociception2.36762369
26MP0005410_abnormal_fertilization2.36357488
27MP0005499_abnormal_olfactory_system2.34757527
28MP0005394_taste/olfaction_phenotype2.34757527
29MP0003880_abnormal_central_pattern2.32752262
30MP0009115_abnormal_fat_cell2.32040705
31MP0005275_abnormal_skin_tensile2.29884908
32MP0003959_abnormal_lean_body2.29595453
33MP0004185_abnormal_adipocyte_glucose2.26314787
34MP0000566_synostosis2.18203304
35MP0004215_abnormal_myocardial_fiber2.18189523
36MP0000372_irregular_coat_pigmentation2.14502116
37MP0003705_abnormal_hypodermis_morpholog2.09951910
38MP0004036_abnormal_muscle_relaxation2.07081793
39MP0003315_abnormal_perineum_morphology2.06415114
40MP0003635_abnormal_synaptic_transmissio2.04375440
41MP0005423_abnormal_somatic_nervous2.03396103
42MP0002184_abnormal_innervation2.01553704
43MP0002734_abnormal_mechanical_nocicepti1.99743946
44MP0001968_abnormal_touch/_nociception1.96267749
45MP0002752_abnormal_somatic_nervous1.93241082
46MP0003879_abnormal_hair_cell1.89831596
47MP0002733_abnormal_thermal_nociception1.87600047
48MP0000778_abnormal_nervous_system1.82358717
49MP0003828_pulmonary_edema1.78941273
50MP0002837_dystrophic_cardiac_calcinosis1.78235357
51MP0005391_vision/eye_phenotype1.73526528
52MP0005377_hearing/vestibular/ear_phenot1.72486840
53MP0003878_abnormal_ear_physiology1.72486840
54MP0002063_abnormal_learning/memory/cond1.71919497
55MP0000733_abnormal_muscle_development1.71905725
56MP0002653_abnormal_ependyma_morphology1.69671181
57MP0002876_abnormal_thyroid_physiology1.68493031
58MP0002638_abnormal_pupillary_reflex1.64891240
59MP0001879_abnormal_lymphatic_vessel1.64094531
60MP0002332_abnormal_exercise_endurance1.63823388
61MP0000534_abnormal_ureter_morphology1.61947674
62MP0005195_abnormal_posterior_eye1.61230680
63MP0005408_hypopigmentation1.59935006
64MP0002970_abnormal_white_adipose1.59708247
65MP0004742_abnormal_vestibular_system1.58553148
66MP0002272_abnormal_nervous_system1.57368358
67MP0005330_cardiomyopathy1.56990276
68MP0005623_abnormal_meninges_morphology1.56453923
69MP0003121_genomic_imprinting1.56372250
70MP0002234_abnormal_pharynx_morphology1.55735792
71MP0001970_abnormal_pain_threshold1.55514915
72MP0003646_muscle_fatigue1.54453047
73MP0002882_abnormal_neuron_morphology1.53335630
74MP0008961_abnormal_basal_metabolism1.51640781
75MP0000749_muscle_degeneration1.49375189
76MP0002751_abnormal_autonomic_nervous1.48185844
77MP0004381_abnormal_hair_follicle1.48137870
78MP0002572_abnormal_emotion/affect_behav1.43743478
79MP0002089_abnormal_postnatal_growth/wei1.42776585
80MP0010329_abnormal_lipoprotein_level1.41577607
81MP0008438_abnormal_cutaneous_collagen1.41019444
82MP0005334_abnormal_fat_pad1.40255861
83MP0001544_abnormal_cardiovascular_syste1.38531379
84MP0005385_cardiovascular_system_phenoty1.38531379
85MP0002736_abnormal_nociception_after1.38360794
86MP0004087_abnormal_muscle_fiber1.38281744
87MP0000026_abnormal_inner_ear1.35100507
88MP0002229_neurodegeneration1.34872718
89MP0005197_abnormal_uvea_morphology1.30592954
90MP0001963_abnormal_hearing_physiology1.29174744
91MP0002557_abnormal_social/conspecific_i1.29085383
92MP0001440_abnormal_grooming_behavior1.27350360
93MP0005535_abnormal_body_temperature1.27267800
94MP0002697_abnormal_eye_size1.26371281
95MP0002796_impaired_skin_barrier1.24225305
96MP0000759_abnormal_skeletal_muscle1.23474039
97MP0008789_abnormal_olfactory_epithelium1.22977066
98MP0003137_abnormal_impulse_conducting1.22626116
99MP0001661_extended_life_span1.20297914
100MP0002064_seizures1.19944569
101MP0001984_abnormal_olfaction1.19413388
102MP0003385_abnormal_body_wall1.17398462
103MP0003938_abnormal_ear_development1.17017709
104MP0004510_myositis1.16999160
105MP0000015_abnormal_ear_pigmentation1.16545197
106MP0002972_abnormal_cardiac_muscle1.15711101
107MP0000049_abnormal_middle_ear1.15648120
108MP0003186_abnormal_redox_activity1.15527009
109MP0004264_abnormal_extraembryonic_tissu1.14076485
110MP0000013_abnormal_adipose_tissue1.12178966
111MP0006036_abnormal_mitochondrial_physio1.11990499
112MP0002932_abnormal_joint_morphology1.11834433
113MP0000955_abnormal_spinal_cord1.11291625
114MP0000678_abnormal_parathyroid_gland1.10283690
115MP0005379_endocrine/exocrine_gland_phen1.08842453
116MP0003942_abnormal_urinary_system1.07782530
117MP0000343_altered_response_to1.07593823
118MP0005620_abnormal_muscle_contractility1.07440774
119MP0002067_abnormal_sensory_capabilities1.07386805
120MP0002254_reproductive_system_inflammat1.07331830
121MP0009250_abnormal_appendicular_skeleto1.06841745
122MP0000631_abnormal_neuroendocrine_gland1.05984275
123MP0000371_diluted_coat_color1.05094615
124MP0002092_abnormal_eye_morphology1.04684611
125MP0005503_abnormal_tendon_morphology1.04229543
126MP0003861_abnormal_nervous_system1.02006845
127MP0010630_abnormal_cardiac_muscle1.00282071
128MP0001324_abnormal_eye_pigmentation0.99934339
129MP0005448_abnormal_energy_balance0.99742600
130MP0003279_aneurysm0.98505597
131MP0008775_abnormal_heart_ventricle0.98200124
132MP0003950_abnormal_plasma_membrane0.95983277
133MP0002877_abnormal_melanocyte_morpholog0.95184677
134MP0002090_abnormal_vision0.95013293
135MP0002249_abnormal_larynx_morphology0.94354750
136MP0001502_abnormal_circadian_rhythm0.94153228
137MP0002233_abnormal_nose_morphology0.93958162
138MP0002118_abnormal_lipid_homeostasis0.91769639
139MP0005167_abnormal_blood-brain_barrier0.91448090
140MP0009745_abnormal_behavioral_response0.91092163
141MP0002909_abnormal_adrenal_gland0.90840631
142MP0001346_abnormal_lacrimal_gland0.90635702
143MP0004133_heterotaxia0.90382164
144MP0002822_catalepsy0.88539410
145MP0010368_abnormal_lymphatic_system0.87006159
146MP0005452_abnormal_adipose_tissue0.86956502
147MP0001286_abnormal_eye_development0.86535683
148MP0002269_muscular_atrophy0.85122529
149MP0001293_anophthalmia0.82914650
150MP0002102_abnormal_ear_morphology0.82152680
151MP0001485_abnormal_pinna_reflex0.82115660
152MP0004885_abnormal_endolymph0.81710001
153MP0002114_abnormal_axial_skeleton0.81613856
154MP0009046_muscle_twitch0.81408894
155MP0001727_abnormal_embryo_implantation0.80486308
156MP0004811_abnormal_neuron_physiology0.79222917
157MP0002081_perinatal_lethality0.78497740
158MP0005257_abnormal_intraocular_pressure0.77733213
159MP0003698_abnormal_male_reproductive0.76792067
160MP0002152_abnormal_brain_morphology0.76328188
161MP0001849_ear_inflammation0.76249224
162MP0002127_abnormal_cardiovascular_syste0.75732886
163MP0003787_abnormal_imprinting0.75621580
164MP0004484_altered_response_of0.74861205
165MP0000249_abnormal_blood_vessel0.74859977
166MP0000750_abnormal_muscle_regeneration0.74311547
167MP0002277_abnormal_respiratory_mucosa0.74190928
168MP0004142_abnormal_muscle_tone0.74094167
169MP0000762_abnormal_tongue_morphology0.73022363
170MP0005647_abnormal_sex_gland0.71651969
171MP0005369_muscle_phenotype0.71471030
172MP0004272_abnormal_basement_membrane0.70797208
173MP0002095_abnormal_skin_pigmentation0.70313496
174MP0002060_abnormal_skin_morphology0.70194690
175MP0000579_abnormal_nail_morphology0.69867763
176MP0002066_abnormal_motor_capabilities/c0.69574722
177MP0002108_abnormal_muscle_morphology0.69509583
178MP0009053_abnormal_anal_canal0.67318421
179MP0004782_abnormal_surfactant_physiolog0.66534004
180MP0009780_abnormal_chondrocyte_physiolo0.66306675
181MP0005266_abnormal_metabolism0.62579018
182MP0005595_abnormal_vascular_smooth0.62422797
183MP0005075_abnormal_melanosome_morpholog0.61059408
184MP0002295_abnormal_pulmonary_circulatio0.58684598
185MP0000747_muscle_weakness0.58473448
186MP0000681_abnormal_thyroid_gland0.58048266
187MP0003948_abnormal_gas_homeostasis0.57677570

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.30840975
2Bilateral microphthalmos (HP:0007633)4.98845369
3Pendular nystagmus (HP:0012043)4.97715805
4Acanthosis nigricans (HP:0000956)4.88008927
5Congenital malformation of the right heart (HP:0011723)4.72387920
6Double outlet right ventricle (HP:0001719)4.72387920
7Asymmetric septal hypertrophy (HP:0001670)4.45538859
8Ventricular tachycardia (HP:0004756)4.41417290
9Hypertriglyceridemia (HP:0002155)4.39803654
10Neoplasm of the heart (HP:0100544)4.33166510
11Oligomenorrhea (HP:0000876)4.27994909
12Concave nail (HP:0001598)4.09346711
13Decreased central vision (HP:0007663)3.96820000
14Increased variability in muscle fiber diameter (HP:0003557)3.88672828
15Abnormal rod and cone electroretinograms (HP:0008323)3.83177156
16Increased corneal curvature (HP:0100692)3.76313606
17Keratoconus (HP:0000563)3.76313606
18Bony spicule pigmentary retinopathy (HP:0007737)3.58837927
19Muscle fiber splitting (HP:0003555)3.58185219
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.56674296
21Hepatoblastoma (HP:0002884)3.55167598
22Febrile seizures (HP:0002373)3.51366351
23Ependymoma (HP:0002888)3.45501424
24Lipoatrophy (HP:0100578)3.45055324
25Sudden death (HP:0001699)3.44805268
26Failure to thrive in infancy (HP:0001531)3.38646796
27Septo-optic dysplasia (HP:0100842)3.25707563
28Abnormality of skeletal muscle fiber size (HP:0012084)3.25155388
29Atrial fibrillation (HP:0005110)3.15768212
30Generalized hypotonia (HP:0001290)3.15741522
31Supraventricular tachycardia (HP:0004755)3.15705972
32Supraventricular arrhythmia (HP:0005115)3.12203332
33Periauricular skin pits (HP:0100277)3.12196324
34Preauricular pit (HP:0004467)3.12196324
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.11359728
36Hypoplasia of the fovea (HP:0007750)3.11359728
37Focal seizures (HP:0007359)3.08861592
38Abnormality of the aortic arch (HP:0012303)3.08278839
39Protrusio acetabuli (HP:0003179)3.06353229
40Focal motor seizures (HP:0011153)3.02702648
41Primary atrial arrhythmia (HP:0001692)2.99473471
42White forelock (HP:0002211)2.96364251
43Hypoplastic left heart (HP:0004383)2.92975482
44Scotoma (HP:0000575)2.91630589
45Insulin resistance (HP:0000855)2.86431805
46Bulbar palsy (HP:0001283)2.85816444
47Abnormality of the lower motor neuron (HP:0002366)2.85705859
48Chorioretinal atrophy (HP:0000533)2.84522284
49Pulmonary artery stenosis (HP:0004415)2.83134259
50Visual hallucinations (HP:0002367)2.78992583
51Hyporeflexia of lower limbs (HP:0002600)2.75119091
52Cone-rod dystrophy (HP:0000548)2.74880166
53Tented upper lip vermilion (HP:0010804)2.69138172
54Increased connective tissue (HP:0009025)2.69099985
55Hemiparesis (HP:0001269)2.67386644
56Spinal rigidity (HP:0003306)2.65520939
57Bifid tongue (HP:0010297)2.63744131
58Abnormal connection of the cardiac segments (HP:0011545)2.63634395
59Abnormal ventriculo-arterial connection (HP:0011563)2.63634395
60Transposition of the great arteries (HP:0001669)2.63634395
61Cerebral aneurysm (HP:0004944)2.63404674
62Astrocytoma (HP:0009592)2.62401130
63Abnormality of the astrocytes (HP:0100707)2.62401130
64Dilated cardiomyopathy (HP:0001644)2.61817594
65Subaortic stenosis (HP:0001682)2.60784803
66Abnormality of the left ventricular outflow tract (HP:0011103)2.60784803
67Central scotoma (HP:0000603)2.60385321
68Difficulty running (HP:0009046)2.60071126
69Colitis (HP:0002583)2.58790365
70Right ventricular cardiomyopathy (HP:0011663)2.58191982
71Severe Myopia (HP:0011003)2.56579639
72Nausea (HP:0002018)2.56263613
73Insulin-resistant diabetes mellitus (HP:0000831)2.56050757
74Atrioventricular block (HP:0001678)2.55627329
75Generalized aminoaciduria (HP:0002909)2.55590653
76Abnormality of glycolysis (HP:0004366)2.53195941
77Increased serum pyruvate (HP:0003542)2.53195941
78Aplasia/Hypoplasia of the macula (HP:0008059)2.50970213
79Bell-shaped thorax (HP:0001591)2.48500710
80Dyschromatopsia (HP:0007641)2.47807929
81Hypochromic microcytic anemia (HP:0004840)2.47599858
82Patchy hypopigmentation of hair (HP:0011365)2.46891961
83Unilateral renal agenesis (HP:0000122)2.45581004
84Neoplasm of striated muscle (HP:0009728)2.44432375
85Upper limb muscle weakness (HP:0003484)2.43389817
86Frequent falls (HP:0002359)2.39894114
87Sex reversal (HP:0012245)2.37723108
88Abnormal sex determination (HP:0012244)2.37723108
89Hypoplasia of the iris (HP:0007676)2.35168945
90Hypotrichosis (HP:0001006)2.33808597
91Symphalangism affecting the phalanges of the hand (HP:0009773)2.32768519
92Hypoplastic heart (HP:0001961)2.32416669
93Polar cataract (HP:0010696)2.32040465
94Abnormality of the fovea (HP:0000493)2.31611887
95Long toe (HP:0010511)2.31451401
96Type 1 muscle fiber predominance (HP:0003803)2.29844840
97Aplasia/hypoplasia of the humerus (HP:0006507)2.29689313
98Amblyopia (HP:0000646)2.29122227
99Amyotrophic lateral sclerosis (HP:0007354)2.28047459
100Dialeptic seizures (HP:0011146)2.26809975
101Polyphagia (HP:0002591)2.25634434
102Bladder carcinoma (HP:0002862)2.24455055
103Bladder neoplasm (HP:0009725)2.24455055
104Exotropia (HP:0000577)2.24198729
105Skin pits (HP:0100276)2.20543756
106Growth hormone deficiency (HP:0000824)2.20051477
107Bundle branch block (HP:0011710)2.19423371
108Vertebral compression fractures (HP:0002953)2.19282127
109Cortical dysplasia (HP:0002539)2.18671828
110Absence seizures (HP:0002121)2.18536578
111Resting tremor (HP:0002322)2.17781421
112Rhabdomyolysis (HP:0003201)2.17423601
113Rib fusion (HP:0000902)2.17212228
114Tongue fasciculations (HP:0001308)2.16657823
115Leiomyosarcoma (HP:0100243)2.15967773
116Uterine leiomyosarcoma (HP:0002891)2.15967773
117Abnormal atrioventricular conduction (HP:0005150)2.15370481
118Epileptic encephalopathy (HP:0200134)2.15286243
119Abnormality of the costochondral junction (HP:0000919)2.14956152
120Abnormality of macular pigmentation (HP:0008002)2.14196871
121Hypercholesterolemia (HP:0003124)2.13898723
122Short humerus (HP:0005792)2.10808567
123Neck muscle weakness (HP:0000467)2.09586564
124Renal cell carcinoma (HP:0005584)2.09179248
125Skin nodule (HP:0200036)2.08956576
126Exercise-induced myalgia (HP:0003738)2.08680624
127Hypoplastic ischia (HP:0003175)2.08253604
128Anterior segment dysgenesis (HP:0007700)2.07940404
129Foot dorsiflexor weakness (HP:0009027)2.07099056
130Hypoventilation (HP:0002791)2.06378915
131Aplasia/Hypoplasia affecting the retina (HP:0008061)2.06133466
132Lymphangioma (HP:0100764)2.05539094
133Increased IgM level (HP:0003496)2.05417953
134Abnormality of the lacrimal duct (HP:0011481)2.05126072
135Syncope (HP:0001279)2.05013245
136Atelectasis (HP:0100750)2.04734782
137Myoglobinuria (HP:0002913)2.04712630
138Heart block (HP:0012722)2.04644169
139Back pain (HP:0003418)2.04416005
140Abolished electroretinogram (ERG) (HP:0000550)2.04364143
141Aplasia/Hypoplasia of the lens (HP:0008063)2.03020224
142Stridor (HP:0010307)2.02916084
143Reduced subcutaneous adipose tissue (HP:0003758)2.02876196
144Anal stenosis (HP:0002025)2.02518998
145Myocardial infarction (HP:0001658)2.02507977
146Ectopia lentis (HP:0001083)2.01501832
147Truncus arteriosus (HP:0001660)2.00580285
148Severe visual impairment (HP:0001141)2.00153745
149Bone cyst (HP:0012062)2.00097159
150Abnormality of the phalanges of the hallux (HP:0010057)1.99964446
151Abnormality of the ischium (HP:0003174)1.99944652
152Transitional cell carcinoma of the bladder (HP:0006740)1.98014481
153Hypopigmentation of the fundus (HP:0007894)1.97960565
154Abnormality of fatty-acid metabolism (HP:0004359)1.97467356
155Macular degeneration (HP:0000608)1.97227039
156Axonal loss (HP:0003447)1.96921382
157Metaphyseal dysplasia (HP:0100255)1.95715501
158Abnormality of the nasal mucosa (HP:0000433)1.95715240
159Hyperlipoproteinemia (HP:0010980)1.95005851
160Distal lower limb muscle weakness (HP:0009053)1.94640986
161Hypoalphalipoproteinemia (HP:0003233)1.94173749
162Infantile muscular hypotonia (HP:0008947)1.93841578
163Abnormality of the labia minora (HP:0012880)1.93295702
164Abnormality of the foot musculature (HP:0001436)1.92764025
165Horizontal nystagmus (HP:0000666)1.91433643
166Muscle fibrillation (HP:0010546)1.91375449
167Nasolacrimal duct obstruction (HP:0000579)1.90800890
168Absent speech (HP:0001344)1.90635943
169Ocular albinism (HP:0001107)1.90359423
170Albinism (HP:0001022)1.89983207
171Increased muscle lipid content (HP:0009058)1.89622067
172Type II diabetes mellitus (HP:0005978)1.89125633
173Broad nasal tip (HP:0000455)1.88839132
174Open mouth (HP:0000194)1.87673153
175Short 5th finger (HP:0009237)1.87179478
176Partial duplication of thumb phalanx (HP:0009944)1.87108589
177Prominent supraorbital ridges (HP:0000336)1.85488528
178Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84889505
179Hyperkalemia (HP:0002153)1.84252659
180Supernumerary nipples (HP:0002558)1.84201100
181Abnormality of the pubic bones (HP:0003172)1.83471721
182Shawl scrotum (HP:0000049)1.82576938
183Renal dysplasia (HP:0000110)1.82307003
184Abnormality of the anterior chamber (HP:0000593)1.82041981
185Abnormal EKG (HP:0003115)1.81775538
186Vitreoretinal degeneration (HP:0000655)1.80773527
187Trigonocephaly (HP:0000243)1.80385797
188Partial duplication of the phalanx of hand (HP:0009999)1.79962698
189Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79640371
190Pigmentary retinal degeneration (HP:0001146)1.79258934
191Abnormality of the nasolacrimal system (HP:0000614)1.77249392
192Renal duplication (HP:0000075)1.76134118
193Specific learning disability (HP:0001328)1.73143585
194Abnormality of chromosome segregation (HP:0002916)1.73115042
195Abnormality of calcium-phosphate metabolism (HP:0100530)1.72990472
196Anophthalmia (HP:0000528)1.72182287
197Choroideremia (HP:0001139)1.71534265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.21758646
2BCR4.02255636
3SMG13.89839720
4INSRR3.82992463
5SIK33.71176424
6TAF13.57555491
7GRK53.57144011
8TRIB33.51260492
9TESK13.42365109
10GRK12.81507444
11STK38L2.80293815
12VRK22.73603795
13ERBB32.62011120
14CDK122.57689989
15WNK32.54907394
16MYLK2.44460228
17TYRO32.39054221
18NTRK22.35873907
19PRKD32.34110700
20MARK12.24626458
21PNCK2.17619521
22DYRK22.16053807
23NEK92.08363970
24TIE12.00309279
25ICK1.95216041
26EEF2K1.91787287
27UHMK11.82772174
28TLK11.73370247
29SCYL21.72968573
30EPHB21.72902950
31KSR11.71621239
32PRKAA21.69987269
33KDR1.61471829
34CDC42BPA1.60901122
35CDK191.60684356
36PAK61.55670706
37MINK11.55503305
38GRK61.54694202
39ADRBK21.54655409
40MAPK151.50667532
41ERN11.50470887
42MAPKAPK31.49024518
43ARAF1.46917240
44ABL21.44159274
45PLK41.40737423
46MAPKAPK51.40628722
47LIMK11.39897786
48DYRK1B1.38855112
49STK381.38695694
50NTRK11.34780659
51MAP3K61.31062252
52MAP2K41.30638464
53MAPK41.29283216
54RIPK11.27230541
55DYRK1A1.26833720
56NEK11.26569671
57MAPK121.24615408
58MAPK111.22376013
59CDK181.21423928
60ERBB21.20016337
61MATK1.18157004
62KSR21.12653184
63ADRBK11.12289141
64TGFBR21.08597806
65CAMK11.07952380
66CDK141.03880308
67CDK151.03117608
68WNK11.00498925
69CASK1.00498176
70CDK70.97914677
71CDK50.95850414
72BRAF0.95455214
73CAMK40.95062005
74OXSR10.94139339
75CDK11A0.90757411
76AKT20.90341350
77PDPK10.90105492
78PKN10.89756414
79CSF1R0.89014720
80ALK0.85966877
81LATS20.85561002
82MARK20.85078483
83MAP3K40.84424710
84MST1R0.82058950
85FGFR20.81446937
86MAP3K100.81397832
87TBK10.80974717
88TTN0.80742763
89FER0.79962973
90LATS10.79345146
91MAPK70.79111784
92CAMK1G0.76796221
93MAP2K10.76766165
94GRK70.76741584
95OBSCN0.75947541
96PAK30.75013249
97SIK20.70124782
98BLK0.69181429
99WEE10.68122738
100TNIK0.67312892
101ILK0.67228444
102DMPK0.65941982
103IRAK20.64050338
104MAP2K60.62204400
105EPHA20.62174842
106NME20.62112407
107FGFR10.61275686
108IRAK30.61059728
109NTRK30.60640724
110TRPM70.60256121
111PDGFRA0.59287885
112PRKAA10.57902813
113HIPK20.57733024
114BCKDK0.56614161
115AURKA0.55035512
116MAP3K30.53949236
117DYRK30.53720446
118MAP3K10.53022024
119FGFR30.52022055
120BMPR1B0.51507787
121STK160.51052448
122DDR20.50898888
123SIK10.48297103
124PRKD10.48263662
125TTK0.48075854
126STK110.47401099
127CSNK1E0.46892715
128MAPK130.45920973
129PRKG20.44874299
130FGFR40.44728757
131PIK3CG0.43085508
132MAPK100.43038030
133MAPK90.42604538
134ROCK10.42233641
135LMTK20.42190259
136CDK90.41946105
137ERBB40.41523620
138MOS0.38396559
139CDK40.37975347
140CAMK1D0.37788826
141PRKCH0.37511355
142PHKG20.36799588
143PHKG10.36799588
144STK100.36382604
145DAPK30.36187792
146SGK2230.35591391
147SGK4940.35591391
148PDK10.35392417
149STK390.35227264
150RPS6KA20.34742006
151PRKACB0.34305000
152CHEK20.33164180
153PRKG10.32827634
154CSNK1G30.32015694
155GSK3A0.31969176
156PRKCG0.30805491
157MTOR0.30751320
158DAPK10.30524769
159TAOK10.29914953
160VRK10.29304379
161CSNK1A1L0.28770965
162CSK0.28531336
163MAP3K130.28502525
164CCNB10.26755887
165PRKACG0.26356707
166RPS6KA60.25520822
167TYK20.23656019
168MAP3K20.22817494
169PRKACA0.21472793
170CSNK1G20.21039628
171PKN20.20445382

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.95956504
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.32453337
3PPAR signaling pathway_Homo sapiens_hsa033204.20386817
4Phenylalanine metabolism_Homo sapiens_hsa003603.93524647
5Nicotine addiction_Homo sapiens_hsa050333.38827804
6Fatty acid biosynthesis_Homo sapiens_hsa000613.14715985
7Fatty acid degradation_Homo sapiens_hsa000713.11730757
8Tyrosine metabolism_Homo sapiens_hsa003503.03518321
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.00387433
10Glycerolipid metabolism_Homo sapiens_hsa005612.70338218
11Synaptic vesicle cycle_Homo sapiens_hsa047212.57471059
12Axon guidance_Homo sapiens_hsa043602.47187034
13Adipocytokine signaling pathway_Homo sapiens_hsa049202.30613968
14GABAergic synapse_Homo sapiens_hsa047272.29951601
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27745944
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23199315
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.13687472
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.13147616
19Basal cell carcinoma_Homo sapiens_hsa052172.11507317
20Glutamatergic synapse_Homo sapiens_hsa047242.05993366
21Fatty acid metabolism_Homo sapiens_hsa012122.01482603
22Pyruvate metabolism_Homo sapiens_hsa006201.97919970
23Histidine metabolism_Homo sapiens_hsa003401.89931948
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82888717
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82263927
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79726715
27Morphine addiction_Homo sapiens_hsa050321.77780172
28beta-Alanine metabolism_Homo sapiens_hsa004101.77177942
29Fatty acid elongation_Homo sapiens_hsa000621.76281078
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74089654
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69387879
32Circadian entrainment_Homo sapiens_hsa047131.64496547
33Cholinergic synapse_Homo sapiens_hsa047251.60060851
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.59279287
35Arginine and proline metabolism_Homo sapiens_hsa003301.56039686
36Dopaminergic synapse_Homo sapiens_hsa047281.53868070
37Cardiac muscle contraction_Homo sapiens_hsa042601.39066535
38Hedgehog signaling pathway_Homo sapiens_hsa043401.37771413
39Endometrial cancer_Homo sapiens_hsa052131.34739145
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34338323
41Fat digestion and absorption_Homo sapiens_hsa049751.32857610
42Olfactory transduction_Homo sapiens_hsa047401.31292047
43Hippo signaling pathway_Homo sapiens_hsa043901.30480344
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30393957
45Serotonergic synapse_Homo sapiens_hsa047261.28516934
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.26012408
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25465813
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25006677
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.23565949
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21758963
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19927686
52Inositol phosphate metabolism_Homo sapiens_hsa005621.18631272
53Taste transduction_Homo sapiens_hsa047421.15905797
54GnRH signaling pathway_Homo sapiens_hsa049121.15629322
55ECM-receptor interaction_Homo sapiens_hsa045121.14761522
56Insulin secretion_Homo sapiens_hsa049111.14735360
57VEGF signaling pathway_Homo sapiens_hsa043701.14291846
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12558306
59Ovarian steroidogenesis_Homo sapiens_hsa049131.11171435
60Dilated cardiomyopathy_Homo sapiens_hsa054141.10681718
61Colorectal cancer_Homo sapiens_hsa052101.09272455
62Oxytocin signaling pathway_Homo sapiens_hsa049211.07858501
63Gap junction_Homo sapiens_hsa045401.07632524
64Propanoate metabolism_Homo sapiens_hsa006401.07327933
65Vitamin B6 metabolism_Homo sapiens_hsa007501.06647236
66Fructose and mannose metabolism_Homo sapiens_hsa000511.04529544
67Rap1 signaling pathway_Homo sapiens_hsa040151.02913978
68Choline metabolism in cancer_Homo sapiens_hsa052311.01586499
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99571979
70Calcium signaling pathway_Homo sapiens_hsa040200.99032335
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98893656
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97998052
73Butanoate metabolism_Homo sapiens_hsa006500.97324444
74Insulin signaling pathway_Homo sapiens_hsa049100.96634690
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96360325
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95758458
77Tight junction_Homo sapiens_hsa045300.93024982
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90497965
79Carbon metabolism_Homo sapiens_hsa012000.89662309
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87867974
81Wnt signaling pathway_Homo sapiens_hsa043100.87182368
82Sulfur metabolism_Homo sapiens_hsa009200.86071050
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85764068
84Arachidonic acid metabolism_Homo sapiens_hsa005900.85093767
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84573282
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84066714
87Tryptophan metabolism_Homo sapiens_hsa003800.82061147
88Alzheimers disease_Homo sapiens_hsa050100.80336972
89Linoleic acid metabolism_Homo sapiens_hsa005910.79848144
90Focal adhesion_Homo sapiens_hsa045100.78774208
91Non-small cell lung cancer_Homo sapiens_hsa052230.77449321
92Melanogenesis_Homo sapiens_hsa049160.74850873
93Galactose metabolism_Homo sapiens_hsa000520.74441044
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74344810
95Insulin resistance_Homo sapiens_hsa049310.74323372
96ErbB signaling pathway_Homo sapiens_hsa040120.73497874
97Parkinsons disease_Homo sapiens_hsa050120.71985884
98Pathways in cancer_Homo sapiens_hsa052000.71682499
99Bladder cancer_Homo sapiens_hsa052190.70639661
100mTOR signaling pathway_Homo sapiens_hsa041500.70074450
101Notch signaling pathway_Homo sapiens_hsa043300.69341426
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.68966938
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68653698
104Alcoholism_Homo sapiens_hsa050340.66605197
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.66239965
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65115414
107Glutathione metabolism_Homo sapiens_hsa004800.64889992
108Oxidative phosphorylation_Homo sapiens_hsa001900.63707326
109Salivary secretion_Homo sapiens_hsa049700.63205027
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63184970
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.63159987
112Ras signaling pathway_Homo sapiens_hsa040140.62976693
113Lysine degradation_Homo sapiens_hsa003100.62913657
114Biosynthesis of amino acids_Homo sapiens_hsa012300.62127460
115Long-term potentiation_Homo sapiens_hsa047200.61304459
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60645124
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59864378
118Acute myeloid leukemia_Homo sapiens_hsa052210.58906647
119Long-term depression_Homo sapiens_hsa047300.58844817
120MAPK signaling pathway_Homo sapiens_hsa040100.56824037
121Retinol metabolism_Homo sapiens_hsa008300.55589296
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.55552346
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.55289788
124Glioma_Homo sapiens_hsa052140.54095198
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51473160
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49049446
127AMPK signaling pathway_Homo sapiens_hsa041520.47501703
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46397318
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45690068
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45557189
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44342516
132Sulfur relay system_Homo sapiens_hsa041220.44248669
133Renin secretion_Homo sapiens_hsa049240.43622793
134Oocyte meiosis_Homo sapiens_hsa041140.43416869
135cAMP signaling pathway_Homo sapiens_hsa040240.42787298
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40721108
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39305674
138Arginine biosynthesis_Homo sapiens_hsa002200.38487888
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38136688
140Melanoma_Homo sapiens_hsa052180.36056873
141Estrogen signaling pathway_Homo sapiens_hsa049150.34939039
142Proteoglycans in cancer_Homo sapiens_hsa052050.34395505
143Endocytosis_Homo sapiens_hsa041440.34200517
144Adherens junction_Homo sapiens_hsa045200.34077767
145Peroxisome_Homo sapiens_hsa041460.33788689
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33055881
147Renin-angiotensin system_Homo sapiens_hsa046140.32444585
148Huntingtons disease_Homo sapiens_hsa050160.32187496
149Malaria_Homo sapiens_hsa051440.31513407
150Thyroid cancer_Homo sapiens_hsa052160.29339473
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27759064
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.27475745
153Glucagon signaling pathway_Homo sapiens_hsa049220.27398068
154ABC transporters_Homo sapiens_hsa020100.27157787
155Chemical carcinogenesis_Homo sapiens_hsa052040.24748887
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.24689634
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23082327
158Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21680126
159Dorso-ventral axis formation_Homo sapiens_hsa043200.19439914
160Small cell lung cancer_Homo sapiens_hsa052220.17655909
161Prion diseases_Homo sapiens_hsa050200.17609196
162Metabolic pathways_Homo sapiens_hsa011000.17489144
163Prostate cancer_Homo sapiens_hsa052150.16421657
164SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16017156
165Viral myocarditis_Homo sapiens_hsa054160.15256297

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