IRX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.47148719
2hemidesmosome assembly (GO:0031581)7.27185530
3pattern specification involved in kidney development (GO:0061004)6.78154878
4planar cell polarity pathway involved in neural tube closure (GO:0090179)5.04075955
5ear development (GO:0043583)4.97313025
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.64565979
7segment specification (GO:0007379)4.18235354
8uterus development (GO:0060065)4.12187690
9endocardial cushion morphogenesis (GO:0003203)4.11882238
10mesenchyme morphogenesis (GO:0072132)4.06738762
11lateral sprouting from an epithelium (GO:0060601)4.04684356
12outer ear morphogenesis (GO:0042473)4.01612832
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.96216677
14keratinocyte proliferation (GO:0043616)3.95227496
15mammary gland epithelial cell differentiation (GO:0060644)3.94061035
16positive regulation of gastrulation (GO:2000543)3.93648965
17chondrocyte proliferation (GO:0035988)3.87254734
18regulation of heart morphogenesis (GO:2000826)3.82733664
19skin morphogenesis (GO:0043589)3.77968650
20collagen fibril organization (GO:0030199)3.77235435
21viral transcription (GO:0019083)3.74696135
22bone trabecula formation (GO:0060346)3.63919280
23establishment of tissue polarity (GO:0007164)3.55814455
24establishment of planar polarity (GO:0001736)3.55814455
25heart valve morphogenesis (GO:0003179)3.55089042
26translational termination (GO:0006415)3.54824977
27Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.47642430
28non-canonical Wnt signaling pathway (GO:0035567)3.47122001
29mesenchymal-epithelial cell signaling (GO:0060638)3.46341423
30heart valve formation (GO:0003188)3.44148480
31negative regulation of cell fate specification (GO:0009996)3.42706767
32body morphogenesis (GO:0010171)3.39676578
33cell-substrate junction assembly (GO:0007044)3.39160444
34ribosomal small subunit biogenesis (GO:0042274)3.38918698
35negative regulation of catenin import into nucleus (GO:0035414)3.38015199
36regulation of water loss via skin (GO:0033561)3.37418398
37wound healing, spreading of epidermal cells (GO:0035313)3.35977088
38face development (GO:0060324)3.33837123
39semaphorin-plexin signaling pathway (GO:0071526)3.31308714
40regulation of establishment of planar polarity (GO:0090175)3.30394337
41regulation of cardioblast differentiation (GO:0051890)3.29059298
42hippo signaling (GO:0035329)3.28892719
43epithelial cell maturation (GO:0002070)3.28740518
44positive regulation of keratinocyte differentiation (GO:0045618)3.27964732
45cochlea morphogenesis (GO:0090103)3.26269036
46intestinal epithelial cell development (GO:0060576)3.25972732
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.21878212
48axon extension involved in axon guidance (GO:0048846)3.21878212
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19689655
50limb bud formation (GO:0060174)3.19221523
51atrioventricular valve morphogenesis (GO:0003181)3.17174480
52cell migration in hindbrain (GO:0021535)3.16421413
53keratinocyte differentiation (GO:0030216)3.16009718
54apical protein localization (GO:0045176)3.15561847
55notochord development (GO:0030903)3.14539641
56surfactant homeostasis (GO:0043129)3.12975557
57protein heterotrimerization (GO:0070208)3.12657876
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11176195
59regulation of chromatin binding (GO:0035561)3.09667590
60establishment of skin barrier (GO:0061436)3.09513440
61neural crest cell development (GO:0014032)3.07773299
62regulation of cell proliferation involved in kidney development (GO:1901722)3.07740157
63negative regulation of chondrocyte differentiation (GO:0032331)3.07620346
64negative regulation of cell fate commitment (GO:0010454)3.06702567
65eyelid development in camera-type eye (GO:0061029)3.06631780
66renal filtration (GO:0097205)3.03402706
67negative regulation of axon extension involved in axon guidance (GO:0048843)3.03356148
68polarized epithelial cell differentiation (GO:0030859)3.02804466
69mesonephros development (GO:0001823)3.01744309
70glandular epithelial cell differentiation (GO:0002067)3.01696984
71sympathetic nervous system development (GO:0048485)3.01599606
72paraxial mesoderm development (GO:0048339)3.00575645
73negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.00521062
74endodermal cell differentiation (GO:0035987)3.00121480
75cell migration involved in heart development (GO:0060973)2.97100861
76positive regulation of epithelial to mesenchymal transition (GO:0010718)2.93694663
77glomerular basement membrane development (GO:0032836)2.93608547
78regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93398771
79positive regulation of stem cell differentiation (GO:2000738)2.92714123
80glomerular filtration (GO:0003094)2.92698295
81regulation of fatty acid beta-oxidation (GO:0031998)2.92478908
82outflow tract septum morphogenesis (GO:0003148)2.91782301
83odontogenesis (GO:0042476)2.90448293
84mammary gland alveolus development (GO:0060749)2.89091459
85mesodermal cell differentiation (GO:0048333)2.88664421
86neuron fate specification (GO:0048665)2.88244938
87plasma membrane repair (GO:0001778)2.88078600
88middle ear morphogenesis (GO:0042474)2.87179220
89lens fiber cell development (GO:0070307)2.86526858
90craniofacial suture morphogenesis (GO:0097094)2.86359368
91pharyngeal system development (GO:0060037)2.85394548
92positive regulation of mesenchymal cell proliferation (GO:0002053)2.84563251
93cell adhesion mediated by integrin (GO:0033627)2.84485910
94epidermis development (GO:0008544)2.83620329
95regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83351367
96establishment of monopolar cell polarity (GO:0061162)2.82905853
97establishment or maintenance of monopolar cell polarity (GO:0061339)2.82905853
98epithelial cell-cell adhesion (GO:0090136)2.82890873
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82663543
100cardiac right ventricle morphogenesis (GO:0003215)2.82620938
101negative regulation of keratinocyte proliferation (GO:0010839)2.80790156
102mesenchymal cell development (GO:0014031)2.80234473
103lung-associated mesenchyme development (GO:0060484)2.80174346
104regulation of cell fate specification (GO:0042659)2.80015742
105wound healing, spreading of cells (GO:0044319)2.79052113
106positive regulation of fatty acid beta-oxidation (GO:0032000)2.77593689
107regulation of mesenchymal cell proliferation (GO:0010464)2.77547819
108regulation of hippo signaling (GO:0035330)2.76944381
109translational elongation (GO:0006414)2.76828012
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.76762312
111regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.76253436
112negative regulation of embryonic development (GO:0045992)2.76017947
113cranial suture morphogenesis (GO:0060363)2.75783485
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75720369
115lung epithelium development (GO:0060428)2.74885065
116viral life cycle (GO:0019058)2.74696053
117protein targeting to ER (GO:0045047)2.72774183
118norepinephrine metabolic process (GO:0042415)2.71545068
119cell surface receptor signaling pathway involved in heart development (GO:0061311)2.71448870
120ectoderm development (GO:0007398)2.71104853
121sphingoid metabolic process (GO:0046519)2.70662979
122keratinocyte development (GO:0003334)2.70507371
123cotranslational protein targeting to membrane (GO:0006613)2.70249790
124chondrocyte development (GO:0002063)2.70023099
125chemical homeostasis within a tissue (GO:0048875)2.69940375
126regulation of somitogenesis (GO:0014807)2.69796625
127cardiac muscle cell proliferation (GO:0060038)2.68736144
128negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.67670012
129collagen metabolic process (GO:0032963)2.67409944
130left/right pattern formation (GO:0060972)2.66989507
131proximal/distal pattern formation (GO:0009954)2.66260428
132establishment of apical/basal cell polarity (GO:0035089)2.66164102
133embryonic body morphogenesis (GO:0010172)2.65975537
134hair follicle development (GO:0001942)2.63366315
135positive regulation of action potential (GO:0045760)2.62527019
136branching involved in mammary gland duct morphogenesis (GO:0060444)2.62522843
137regulation of axon extension involved in axon guidance (GO:0048841)2.62218842
138endothelial cell chemotaxis (GO:0035767)2.62084531
139axonemal dynein complex assembly (GO:0070286)2.60712414
140branching involved in salivary gland morphogenesis (GO:0060445)2.59971019
141camera-type eye morphogenesis (GO:0048593)2.59355531
142response to food (GO:0032094)2.57604168
143asymmetric protein localization (GO:0008105)2.55452556
144negative regulation of organelle assembly (GO:1902116)2.54014442
145metanephros development (GO:0001656)2.53489264
146regulation of histone H3-K27 methylation (GO:0061085)2.53127036
147lung secretory cell differentiation (GO:0061140)2.53039542
148motile cilium assembly (GO:0044458)2.51347776
149establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.50275525
150multicellular organismal water homeostasis (GO:0050891)2.49885496
151prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.49634815
152establishment or maintenance of bipolar cell polarity (GO:0061245)2.48097403
153establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48097403
154embryonic skeletal joint morphogenesis (GO:0060272)2.48084607
155phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.44698481
156prostate gland growth (GO:0060736)2.44463404
157positive regulation of epidermal cell differentiation (GO:0045606)2.44362770
158cell differentiation involved in embryonic placenta development (GO:0060706)2.42850161
159negative regulation of fatty acid transport (GO:2000192)2.42835179
160regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.41571119
161cardiac ventricle morphogenesis (GO:0003208)2.41302264
162negative regulation of kidney development (GO:0090185)2.41194801
163dopamine receptor signaling pathway (GO:0007212)2.41153599
164lens morphogenesis in camera-type eye (GO:0002089)2.41081259
165maternal placenta development (GO:0001893)2.40469954
166mesenchymal to epithelial transition (GO:0060231)2.37733711
167dopaminergic neuron differentiation (GO:0071542)2.36961431
168cell-cell signaling involved in cell fate commitment (GO:0045168)2.36572538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.05516575
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.60430889
3* ESR1_20079471_ChIP-ChIP_T-47D_Human3.74149225
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38400267
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04280734
6ESR1_15608294_ChIP-ChIP_MCF-7_Human2.80063983
7ZNF263_19887448_ChIP-Seq_K562_Human2.75214704
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.69100895
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42343753
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39988072
11TP63_17297297_ChIP-ChIP_HaCaT_Human10.7507229
12* TP53_20018659_ChIP-ChIP_R1E_Mouse1.93143554
13EZH2_22144423_ChIP-Seq_EOC_Human1.89247132
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88933839
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85192411
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.84768164
17* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80606317
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.77586630
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77093887
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.77058210
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.75082434
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73062810
23* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73062810
24CJUN_26792858_Chip-Seq_BT549_Human1.70539488
25CLOCK_20551151_ChIP-Seq_293T_Human1.68368562
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62109322
27* EED_16625203_ChIP-ChIP_MESCs_Mouse1.60378249
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.56905848
29TP53_18474530_ChIP-ChIP_U2OS_Human1.56666438
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56564437
31* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54919489
32* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54890612
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54838473
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53087988
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53018355
36* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51970944
37* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51970944
38* CREB1_26743006_Chip-Seq_LNCaP_Human1.51390870
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50922141
40* LXR_22292898_ChIP-Seq_THP-1_Human1.47066479
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46612909
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46318728
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43407528
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.42882475
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40371223
46* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39636030
47* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38760215
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38150738
49* UBF1/2_26484160_Chip-Seq_HMECs_Human1.37888052
50* ISL1_27105846_Chip-Seq_CPCs_Mouse1.36728823
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36372107
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.35899398
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.35528965
54* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34645978
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34291607
56* RNF2_27304074_Chip-Seq_ESCs_Mouse1.33603840
57* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33239108
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32761977
59* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31422521
60* KLF5_25053715_ChIP-Seq_YYC3_Human1.28652300
61* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26595096
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26529901
63AR_21572438_ChIP-Seq_LNCaP_Human1.26488587
64AHR_22903824_ChIP-Seq_MCF-7_Human1.26217650
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26134736
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24596146
67CTCF_27219007_Chip-Seq_Bcells_Human1.23651152
68SOX2_20726797_ChIP-Seq_SW620_Human1.23607711
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23307189
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22652153
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22221697
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.21392562
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.19771188
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19503493
75* GATA3_24758297_ChIP-Seq_MCF-7_Human1.18963200
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18564805
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17921680
78BRD4_25478319_ChIP-Seq_HGPS_Human1.17602129
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17377169
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16393871
81* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15481738
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14746313
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.13781890
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13095210
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13087442
86* CBX2_27304074_Chip-Seq_ESCs_Mouse1.12224501
87RACK7_27058665_Chip-Seq_MCF-7_Human1.10965360
88* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10910287
89* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10657939
90* KDM2B_26808549_Chip-Seq_DND41_Human1.10524513
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09260250
92* TBX20_22080862_ChIP-Seq_HEART_Mouse1.05059960
93* TBX20_22328084_ChIP-Seq_HEART_Mouse1.05059960
94SMC4_20622854_ChIP-Seq_HELA_Human1.05008867
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04837082
96* ATF3_27146783_Chip-Seq_COLON_Human1.04510338
97* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03615937
98P68_20966046_ChIP-Seq_HELA_Human1.03473095
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02961779
100* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02322401
101* KDM2B_26808549_Chip-Seq_K562_Human1.02041011
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02003723
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00802495
104XRN2_22483619_ChIP-Seq_HELA_Human1.00345585
105* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00235931
106RXR_22108803_ChIP-Seq_LS180_Human1.00107608
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00035412
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99688400
109* TP63_23658742_ChIP-Seq_EP156T_Human0.99496676
110* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98954780
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.98591386
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98431480
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98416682
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98408797
115* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97606584
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97112110
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96887291
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95339960
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95306397
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.95110749
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.94771358
122SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94658795
123* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94647846
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94643451
125SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94178347
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93674742
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.93193404
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92057756
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91656321
130VDR_21846776_ChIP-Seq_THP-1_Human0.91350691
131* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91260133
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91245677
133* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91111344
134* RNF2_27304074_Chip-Seq_NSC_Mouse0.90319825
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90120026
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89529908
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88959650
138* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88860644
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88356210
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87415992
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87415992
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.87267459
143TP53_22127205_ChIP-Seq_IMR90_Human0.86032067
144* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83770285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile3.84152430
2MP0010030_abnormal_orbit_morphology3.49459312
3MP0003941_abnormal_skin_development3.32476102
4MP0008438_abnormal_cutaneous_collagen3.17087590
5MP0010234_abnormal_vibrissa_follicle3.10174620
6MP0009780_abnormal_chondrocyte_physiolo3.05987209
7MP0003705_abnormal_hypodermis_morpholog2.87538861
8MP0002796_impaired_skin_barrier2.87073406
9MP0002060_abnormal_skin_morphology2.72855105
10MP0004264_abnormal_extraembryonic_tissu2.51328242
11MP0005623_abnormal_meninges_morphology2.35253219
12MP0005503_abnormal_tendon_morphology2.32150254
13MP0000383_abnormal_hair_follicle2.28459067
14MP0000762_abnormal_tongue_morphology2.27654815
15MP0004272_abnormal_basement_membrane2.26027207
16MP0000566_synostosis2.25429928
17MP0000579_abnormal_nail_morphology2.12152110
18MP0009250_abnormal_appendicular_skeleto2.09348721
19MP0002282_abnormal_trachea_morphology2.08919728
20MP0002234_abnormal_pharynx_morphology2.08389676
21MP0010678_abnormal_skin_adnexa2.03249632
22MP0005501_abnormal_skin_physiology1.99233734
23MP0001958_emphysema1.95062688
24MP0002249_abnormal_larynx_morphology1.89690754
25MP0002098_abnormal_vibrissa_morphology1.88009472
26MP0000537_abnormal_urethra_morphology1.87954211
27MP0003385_abnormal_body_wall1.82335043
28MP0003136_yellow_coat_color1.81447279
29MP0001346_abnormal_lacrimal_gland1.78741340
30MP0003566_abnormal_cell_adhesion1.77403140
31MP0009384_cardiac_valve_regurgitation1.74951245
32MP0003453_abnormal_keratinocyte_physiol1.71964826
33MP0005508_abnormal_skeleton_morphology1.71799827
34MP0000467_abnormal_esophagus_morphology1.70497882
35MP0001216_abnormal_epidermal_layer1.69793773
36MP0004381_abnormal_hair_follicle1.66898119
37MP0005257_abnormal_intraocular_pressure1.66647635
38MP0002254_reproductive_system_inflammat1.66576898
39MP0009053_abnormal_anal_canal1.66374439
40MP0000647_abnormal_sebaceous_gland1.65965674
41MP0010771_integument_phenotype1.65866538
42MP0002877_abnormal_melanocyte_morpholog1.62424542
43MP0009379_abnormal_foot_pigmentation1.61163275
44MP0000377_abnormal_hair_follicle1.59622241
45MP0005423_abnormal_somatic_nervous1.59588242
46MP0004185_abnormal_adipocyte_glucose1.55879867
47MP0001849_ear_inflammation1.55630146
48MP0005248_abnormal_Harderian_gland1.53356539
49MP0003942_abnormal_urinary_system1.51473567
50MP0005409_darkened_coat_color1.49623828
51MP0003755_abnormal_palate_morphology1.46261975
52MP0003937_abnormal_limbs/digits/tail_de1.42073802
53MP0002160_abnormal_reproductive_system1.41985083
54MP0003123_paternal_imprinting1.41406759
55MP0000049_abnormal_middle_ear1.40633422
56MP0002184_abnormal_innervation1.40243718
57MP0000778_abnormal_nervous_system1.39918780
58MP0006054_spinal_hemorrhage1.39794565
59MP0000427_abnormal_hair_cycle1.34820883
60MP0000534_abnormal_ureter_morphology1.31609400
61MP0000462_abnormal_digestive_system1.30233345
62MP0001881_abnormal_mammary_gland1.29141396
63MP0002233_abnormal_nose_morphology1.28017149
64MP0000428_abnormal_craniofacial_morphol1.25643275
65MP0003279_aneurysm1.25070244
66MP0005083_abnormal_biliary_tract1.21917924
67MP0000432_abnormal_head_morphology1.20101586
68MP0005023_abnormal_wound_healing1.18738515
69MP0005076_abnormal_cell_differentiation1.17936907
70MP0004858_abnormal_nervous_system1.17146839
71MP0002896_abnormal_bone_mineralization1.15545048
72* MP0001340_abnormal_eyelid_morphology1.14325731
73MP0003936_abnormal_reproductive_system1.14248762
74MP0002932_abnormal_joint_morphology1.13857816
75MP0003935_abnormal_craniofacial_develop1.11763962
76MP0003115_abnormal_respiratory_system1.11702581
77MP0000163_abnormal_cartilage_morphology1.08416651
78MP0000733_abnormal_muscle_development1.08190245
79MP0004782_abnormal_surfactant_physiolog1.07812538
80MP0001243_abnormal_dermal_layer1.07715879
81MP0002822_catalepsy1.06846440
82MP0002116_abnormal_craniofacial_bone1.06719322
83MP0001299_abnormal_eye_distance/1.05924115
84MP0001919_abnormal_reproductive_system1.04626769
85MP0002089_abnormal_postnatal_growth/wei1.04469843
86MP0002938_white_spotting1.03952684
87MP0002177_abnormal_outer_ear1.03501982
88MP0001727_abnormal_embryo_implantation1.02532860
89MP0010352_gastrointestinal_tract_polyps1.01690831
90MP0002111_abnormal_tail_morphology1.00140301
91MP0000678_abnormal_parathyroid_gland0.99697135
92MP0002102_abnormal_ear_morphology0.97488938
93MP0002653_abnormal_ependyma_morphology0.97098142
94MP0003861_abnormal_nervous_system0.95341170
95MP0001177_atelectasis0.93410052
96MP0003938_abnormal_ear_development0.93014422
97MP0002109_abnormal_limb_morphology0.92207467
98MP0002115_abnormal_skeleton_extremities0.91443878
99MP0003091_abnormal_cell_migration0.89015524
100MP0000627_abnormal_mammary_gland0.88085192
101MP0002108_abnormal_muscle_morphology0.87431994
102MP0002751_abnormal_autonomic_nervous0.86461578
103MP0000516_abnormal_urinary_system0.86421046
104MP0005367_renal/urinary_system_phenotyp0.86421046
105MP0002133_abnormal_respiratory_system0.84401422
106MP0005388_respiratory_system_phenotype0.84401422
107MP0000026_abnormal_inner_ear0.84364841
108MP0003787_abnormal_imprinting0.82431302
109MP0000955_abnormal_spinal_cord0.82372009
110MP0001529_abnormal_vocalization0.81707593
111MP0003315_abnormal_perineum_morphology0.81558266
112MP0000470_abnormal_stomach_morphology0.81440827
113MP0004885_abnormal_endolymph0.80121797
114MP0001348_abnormal_lacrimal_gland0.79375179
115MP0009931_abnormal_skin_appearance0.78864791
116MP0002277_abnormal_respiratory_mucosa0.78715282
117MP0000631_abnormal_neuroendocrine_gland0.78103586
118MP0005666_abnormal_adipose_tissue0.78012962
119MP0001879_abnormal_lymphatic_vessel0.76636074
120MP0001191_abnormal_skin_condition0.76155905
121MP0000538_abnormal_urinary_bladder0.75702613
122MP0005389_reproductive_system_phenotype0.75395415
123MP0005390_skeleton_phenotype0.74734437
124MP0001542_abnormal_bone_strength0.73167566
125MP0008995_early_reproductive_senescence0.73036052
126MP0002092_abnormal_eye_morphology0.72944136
127MP0002697_abnormal_eye_size0.72855892
128MP0005646_abnormal_pituitary_gland0.71834523
129MP0001286_abnormal_eye_development0.70643412
130MP0002113_abnormal_skeleton_development0.69867203
131MP0008789_abnormal_olfactory_epithelium0.69378618
132MP0002295_abnormal_pulmonary_circulatio0.69237929
133MP0005187_abnormal_penis_morphology0.69094616
134MP0010368_abnormal_lymphatic_system0.68855635
135MP0003567_abnormal_fetal_cardiomyocyte0.68272210
136MP0000751_myopathy0.67166749
137MP0002114_abnormal_axial_skeleton0.65299618
138MP0002081_perinatal_lethality0.64315764

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)5.43216528
2Premature rupture of membranes (HP:0001788)5.27634098
3Fragile nails (HP:0001808)4.87115233
4Protrusio acetabuli (HP:0003179)4.46428195
5Onycholysis (HP:0001806)4.44315514
6Milia (HP:0001056)4.26829134
7Shallow orbits (HP:0000586)4.03091326
8Septate vagina (HP:0001153)3.79303137
9Coronal craniosynostosis (HP:0004440)3.72959480
10Neonatal short-limb short stature (HP:0008921)3.48926912
11Fragile skin (HP:0001030)3.48008873
12Plantar hyperkeratosis (HP:0007556)3.44914142
13Partial duplication of thumb phalanx (HP:0009944)3.37212800
14Right ventricular cardiomyopathy (HP:0011663)3.31016422
15Aplasia involving bones of the extremities (HP:0009825)3.03989659
16Aplasia involving bones of the upper limbs (HP:0009823)3.03989659
17Aplasia of the phalanges of the hand (HP:0009802)3.03989659
18Hypotrichosis (HP:0001006)3.00520353
19Woolly hair (HP:0002224)2.82420564
20Bronchomalacia (HP:0002780)2.78681254
21Morphological abnormality of the middle ear (HP:0008609)2.68257958
22Concave nail (HP:0001598)2.66066773
23Abnormal ciliary motility (HP:0012262)2.62137372
24Natal tooth (HP:0000695)2.60575844
25Abnormality of nail color (HP:0100643)2.59370099
26Increased connective tissue (HP:0009025)2.59159288
27Abnormal respiratory motile cilium physiology (HP:0012261)2.57925597
28Soft skin (HP:0000977)2.56670539
29Ankle contracture (HP:0006466)2.55346829
30Broad metatarsal (HP:0001783)2.50364053
31Infantile muscular hypotonia (HP:0008947)2.48537005
32Aplasia cutis congenita (HP:0001057)2.42094173
33Hyperacusis (HP:0010780)2.40727182
34Aortic dissection (HP:0002647)2.39209824
35Renal dysplasia (HP:0000110)2.38624417
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.36105525
37Flat capital femoral epiphysis (HP:0003370)2.34392940
38Abnormality of the phalanges of the hallux (HP:0010057)2.33841584
39Pterygium (HP:0001059)2.30851779
40Advanced eruption of teeth (HP:0006288)2.30837192
41Abnormality of dentin (HP:0010299)2.29365639
42Overgrowth (HP:0001548)2.29106291
43Lip pit (HP:0100267)2.28208646
44Hypercortisolism (HP:0001578)2.28152756
45Spinal rigidity (HP:0003306)2.23831127
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.23670895
47Follicular hyperkeratosis (HP:0007502)2.22466754
48Shawl scrotum (HP:0000049)2.22173833
49Nasolacrimal duct obstruction (HP:0000579)2.22067253
50Obstructive sleep apnea (HP:0002870)2.18726486
51Abnormality of the aortic arch (HP:0012303)2.17459036
52Partial duplication of the phalanx of hand (HP:0009999)2.16525615
53Hyperparathyroidism (HP:0000843)2.14957647
54Macroorchidism (HP:0000053)2.14077564
55Abnormality of the dental root (HP:0006486)2.13826768
56Taurodontia (HP:0000679)2.13826768
57Abnormality of permanent molar morphology (HP:0011071)2.13826768
58Acanthosis nigricans (HP:0000956)2.10211778
59Ridged nail (HP:0001807)2.10077210
60Peritonitis (HP:0002586)2.09546843
61Wormian bones (HP:0002645)2.08211347
62Abnormality of molar morphology (HP:0011070)2.07215882
63Abnormality of molar (HP:0011077)2.07215882
64Buphthalmos (HP:0000557)2.06969116
65Turricephaly (HP:0000262)2.06715293
66J-shaped sella turcica (HP:0002680)2.06055219
67Cerebral aneurysm (HP:0004944)2.05588799
68Mitral valve prolapse (HP:0001634)2.04269439
69Thin bony cortex (HP:0002753)2.03407296
70Hypoplasia of the iris (HP:0007676)2.02135490
71Enlarged penis (HP:0000040)2.02128745
72Deformed sella turcica (HP:0002681)2.01608679
73Absent frontal sinuses (HP:0002688)2.01593723
74Wide anterior fontanel (HP:0000260)2.01093092
75Mildly elevated creatine phosphokinase (HP:0008180)1.99909789
76Nail dystrophy (HP:0008404)1.99477552
77Exostoses (HP:0100777)1.98156801
78Alopecia of scalp (HP:0002293)1.97855012
79Deviation of the hallux (HP:0010051)1.97302135
80Duplication of thumb phalanx (HP:0009942)1.96830575
81Patellar dislocation (HP:0002999)1.96358335
82Maternal diabetes (HP:0009800)1.96227256
83Neoplasm of the heart (HP:0100544)1.95517937
84Absent eyelashes (HP:0000561)1.93742031
85Abnormality of the lacrimal duct (HP:0011481)1.93258645
86Bladder diverticulum (HP:0000015)1.92996503
87Hypoplastic labia majora (HP:0000059)1.92626807
88Abnormal hemoglobin (HP:0011902)1.92623775
89Congenital, generalized hypertrichosis (HP:0004540)1.91181396
90Aplasia of the musculature (HP:0100854)1.90544704
91Hallux valgus (HP:0001822)1.90373092
92Short nail (HP:0001799)1.90206929
93Abnormality of the distal phalanges of the toes (HP:0010182)1.90007390
94Glossoptosis (HP:0000162)1.88865430
95Pili torti (HP:0003777)1.88720318
96Septo-optic dysplasia (HP:0100842)1.88615771
97Bell-shaped thorax (HP:0001591)1.88397515
98* Down-sloping shoulders (HP:0200021)1.88381492
99Blue sclerae (HP:0000592)1.87678106
100Ventricular tachycardia (HP:0004756)1.87370442
101Blepharitis (HP:0000498)1.86932195
102Abnormality of the parietal bone (HP:0002696)1.86483329
103Midline defect of the nose (HP:0004122)1.86241442
104Ankyloglossia (HP:0010296)1.86133798
105Overriding aorta (HP:0002623)1.85870971
106Broad toe (HP:0001837)1.85856077
107Hypoplasia of dental enamel (HP:0006297)1.85150790
108Short femoral neck (HP:0100864)1.84224099
109Parakeratosis (HP:0001036)1.84010592
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.83780612
111Osteolytic defects of the hand bones (HP:0009699)1.83780612
112Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.83314628
113Elbow flexion contracture (HP:0002987)1.82856438
114Asymmetry of the thorax (HP:0001555)1.81748620
115Distal lower limb muscle weakness (HP:0009053)1.81648962
116Genu recurvatum (HP:0002816)1.79462790
117Abnormality of the dental pulp (HP:0006479)1.79421515
118Skin pits (HP:0100276)1.78792713
119Interstitial pulmonary disease (HP:0006530)1.78591176
120Abnormality of the labia majora (HP:0012881)1.78161536
121Missing ribs (HP:0000921)1.77801019
122Broad face (HP:0000283)1.77335173
123Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.75055815
124Broad hallux (HP:0010055)1.74792666
125Palmoplantar hyperkeratosis (HP:0000972)1.74486206
126Dilatation of the ascending aorta (HP:0005111)1.74332304
127Microglossia (HP:0000171)1.73930065
128Esophageal atresia (HP:0002032)1.73551942
129Abnormal blistering of the skin (HP:0008066)1.72975323
130Abnormality of the nasolacrimal system (HP:0000614)1.72499352
131* Hypodontia (HP:0000668)1.72402751
132Absent septum pellucidum (HP:0001331)1.72062455
133Atelectasis (HP:0100750)1.72045055
134Hyperextensible skin (HP:0000974)1.72033803
135Abnormality of the frontal sinuses (HP:0002687)1.71942798
136Tibial bowing (HP:0002982)1.71548257
137Chin dimple (HP:0010751)1.71170739
138Germ cell neoplasia (HP:0100728)1.70989720
139Curly hair (HP:0002212)1.70241238
140Abnormality of the middle phalanges of the hand (HP:0009833)1.70134523
141Sudden death (HP:0001699)1.70022974
142* Sparse lateral eyebrow (HP:0005338)1.69759680
143Lymphangioma (HP:0100764)1.68402077
144Hyporeflexia of lower limbs (HP:0002600)1.68319009
145Type 1 muscle fiber predominance (HP:0003803)1.67545475
146Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66804541
147* Severe Myopia (HP:0011003)1.66411179
148Rectal prolapse (HP:0002035)1.65188832
149Anhidrosis (HP:0000970)1.64710287
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.64666631
151Venous abnormality (HP:0002624)1.64652160
152Hamartoma (HP:0010566)1.64357926
153Hypercalcemia (HP:0003072)1.63950238
154Congenital glaucoma (HP:0001087)1.62759733
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59930377
156Testicular atrophy (HP:0000029)1.59845162
157Elfin facies (HP:0004428)1.58707260
158Vesicoureteral reflux (HP:0000076)1.57130974
159Breast carcinoma (HP:0003002)1.57100816
160Spinal cord compression (HP:0002176)1.57025942
161Abnormality of the epiphyses of the hand (HP:0005924)1.56902832
162Abnormality of the diencephalon (HP:0010662)1.55776154
163Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.54707530
164Ulnar bowing (HP:0003031)1.52510356
165Abnormality of the sella turcica (HP:0002679)1.52243500
166Hemivertebrae (HP:0002937)1.51825852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.46957634
2DDR23.87982695
3EPHB23.58805839
4MST1R3.25110909
5FER3.22769079
6TRIB32.72070067
7LATS22.54509549
8MUSK2.41646374
9SIK12.15381634
10MAPKAPK32.13428473
11LRRK22.02054128
12TTN1.97511762
13STK38L1.90166502
14EEF2K1.89170632
15FGFR21.85632467
16PDGFRA1.81541827
17ICK1.78609893
18EPHA21.78378711
19CASK1.71460464
20PTK61.71244981
21STK31.69661484
22DYRK1B1.69179507
23DMPK1.68447499
24PKN21.67101042
25MET1.66477837
26ERN11.64203060
27RIPK11.62920267
28STK241.60609097
29TRPM71.53983281
30SMG11.52349715
31CDK61.52317466
32RPS6KA41.49744510
33MARK11.44551858
34EPHA31.37356547
35TYRO31.36733991
36BMX1.23534772
37ILK1.22518804
38PNCK1.20993751
39FGFR11.20247539
40NTRK21.16587211
41PAK21.15870769
42TGFBR21.15636309
43CDK71.15536833
44MAP3K31.15153581
45PAK41.15084377
46MAP3K61.10446299
47NME21.10025030
48TESK11.08262678
49CHUK1.06652895
50RPS6KB21.03944440
51RPS6KA61.03480394
52ROCK11.03397586
53WNK11.00677579
54MOS1.00508423
55PIM20.98802215
56PAK30.98554176
57NEK60.94975937
58PDGFRB0.94640836
59PTK20.91027163
60ERBB30.90727986
61PIK3CA0.88703907
62BCR0.88504528
63ERBB20.87608029
64MAP3K90.87024729
65CDK80.81762793
66IRAK30.80822431
67TLK10.80133216
68WNK40.79298691
69MAP2K20.77942863
70MKNK10.76813570
71FGFR40.74835778
72SCYL20.74004479
73DYRK20.73814791
74PRKD10.73497599
75MAP3K100.72968040
76NTRK10.72811017
77FRK0.72277718
78CDK120.69143957
79MARK20.68382128
80EPHB10.67325330
81RET0.66593451
82STK160.66399561
83NLK0.65051332
84NME10.64932184
85PRKD30.64871697
86STK390.64868687
87LMTK20.64520233
88TGFBR10.63485580
89ROCK20.60350162
90PDK40.60009842
91PDK30.60009842
92MAP2K70.59489945
93MST40.59374904
94LIMK10.57944137
95RPS6KB10.56019952
96MAPK150.55068859
97MAP2K10.54003200
98WEE10.53962029
99ADRBK10.53738350
100NEK90.53105771
101STK100.52289339
102CAMK2G0.51036672
103MAPKAPK20.50522006
104FGFR30.49237974
105CAMK1D0.48598254
106IRAK20.48402882
107MAPK40.47706449
108RPS6KA10.47574313
109CSNK1E0.46446990
110MYLK0.45616593
111CDK90.45328943
112ABL20.45203080
113DYRK30.44926578
114BMPR1B0.44708532
115CAMK2D0.44708528
116MTOR0.44446661
117AURKA0.44172758
118RPS6KC10.43838709
119RPS6KL10.43838709
120PTK2B0.42941161
121MAPK80.42322179
122TAOK10.42282100
123MELK0.41620063
124RPS6KA20.41430265
125CAMK2B0.41256340
126IRAK10.41215290
127STK380.39632304
128TAF10.38915946
129CHEK20.37576905
130MINK10.37214160
131PHKG10.37081064
132PHKG20.37081064
133AKT10.36498314
134DAPK30.35717263
135MAP3K20.34876237
136MAPK90.34506103
137PRKD20.33402473
138RPS6KA50.31967635
139UHMK10.31804643
140PAK60.31694595
141PRKCI0.31047277
142HIPK20.30542094
143AURKB0.30369447
144MKNK20.29905818
145CDK140.28656449
146MAP3K10.28500399
147CAMK1G0.28430875
148AKT20.27633860

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.76180157
2ECM-receptor interaction_Homo sapiens_hsa045123.69518165
3Hippo signaling pathway_Homo sapiens_hsa043902.92815018
4Hedgehog signaling pathway_Homo sapiens_hsa043402.89224803
5Ribosome_Homo sapiens_hsa030102.82004538
6Adherens junction_Homo sapiens_hsa045202.51669234
7Proteoglycans in cancer_Homo sapiens_hsa052052.41179043
8Bladder cancer_Homo sapiens_hsa052192.37598087
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.35709306
10Focal adhesion_Homo sapiens_hsa045102.20923468
11Sulfur relay system_Homo sapiens_hsa041222.15306035
12TGF-beta signaling pathway_Homo sapiens_hsa043502.01743557
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.00257147
14Wnt signaling pathway_Homo sapiens_hsa043101.94786230
15Tight junction_Homo sapiens_hsa045301.93435057
16Axon guidance_Homo sapiens_hsa043601.88372047
17Melanogenesis_Homo sapiens_hsa049161.85221645
18Protein digestion and absorption_Homo sapiens_hsa049741.84133778
19Small cell lung cancer_Homo sapiens_hsa052221.78065865
20Amoebiasis_Homo sapiens_hsa051461.76277763
21MicroRNAs in cancer_Homo sapiens_hsa052061.72044552
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70883954
23Dilated cardiomyopathy_Homo sapiens_hsa054141.63664330
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55458530
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.53590880
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53440499
27Notch signaling pathway_Homo sapiens_hsa043301.52894681
28Melanoma_Homo sapiens_hsa052181.50763973
29Dorso-ventral axis formation_Homo sapiens_hsa043201.49735316
30Pathways in cancer_Homo sapiens_hsa052001.41432231
31Chronic myeloid leukemia_Homo sapiens_hsa052201.34278385
32Sphingolipid metabolism_Homo sapiens_hsa006001.33323676
33Endometrial cancer_Homo sapiens_hsa052131.21771349
34Viral myocarditis_Homo sapiens_hsa054161.20348665
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19527826
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.17895434
37Renal cell carcinoma_Homo sapiens_hsa052111.15858748
38Cocaine addiction_Homo sapiens_hsa050301.11429578
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11026164
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10927392
41Prostate cancer_Homo sapiens_hsa052151.08515798
42HTLV-I infection_Homo sapiens_hsa051661.03791029
43Fatty acid biosynthesis_Homo sapiens_hsa000611.02846316
44Thyroid cancer_Homo sapiens_hsa052161.01864377
45Rap1 signaling pathway_Homo sapiens_hsa040151.00874981
46mTOR signaling pathway_Homo sapiens_hsa041500.99869784
47Glioma_Homo sapiens_hsa052140.99447577
48p53 signaling pathway_Homo sapiens_hsa041150.98742023
49Choline metabolism in cancer_Homo sapiens_hsa052310.97825307
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94246609
51ErbB signaling pathway_Homo sapiens_hsa040120.93971108
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.93585072
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93057119
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93030275
55Pancreatic cancer_Homo sapiens_hsa052120.92573338
56VEGF signaling pathway_Homo sapiens_hsa043700.92322486
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91772454
58Malaria_Homo sapiens_hsa051440.90420095
59Colorectal cancer_Homo sapiens_hsa052100.88135821
60Acute myeloid leukemia_Homo sapiens_hsa052210.86752700
61Tyrosine metabolism_Homo sapiens_hsa003500.83178725
62Estrogen signaling pathway_Homo sapiens_hsa049150.82345065
63Huntingtons disease_Homo sapiens_hsa050160.82217396
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80203249
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.78329372
66Steroid biosynthesis_Homo sapiens_hsa001000.78166778
67Vibrio cholerae infection_Homo sapiens_hsa051100.77269826
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75851162
69Ovarian steroidogenesis_Homo sapiens_hsa049130.74291525
70Alcoholism_Homo sapiens_hsa050340.73978236
71Toxoplasmosis_Homo sapiens_hsa051450.73203727
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73052811
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72273692
74Cholinergic synapse_Homo sapiens_hsa047250.69340597
75AMPK signaling pathway_Homo sapiens_hsa041520.68874516
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67950304
77Ras signaling pathway_Homo sapiens_hsa040140.67197253
78GnRH signaling pathway_Homo sapiens_hsa049120.66336124
79Platelet activation_Homo sapiens_hsa046110.66024739
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.65635730
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65252882
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63932317
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63303795
84Glucagon signaling pathway_Homo sapiens_hsa049220.62059879
85Gap junction_Homo sapiens_hsa045400.59809446
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58322774
87Mineral absorption_Homo sapiens_hsa049780.56896043
88Insulin signaling pathway_Homo sapiens_hsa049100.56481602
89cAMP signaling pathway_Homo sapiens_hsa040240.54643370
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53952388
91Phenylalanine metabolism_Homo sapiens_hsa003600.53388327
92Lysine degradation_Homo sapiens_hsa003100.52771340
93Endocytosis_Homo sapiens_hsa041440.52760925
94Dopaminergic synapse_Homo sapiens_hsa047280.52160714
95Cell cycle_Homo sapiens_hsa041100.51176168
96Oxytocin signaling pathway_Homo sapiens_hsa049210.50799485
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45784999
98Prolactin signaling pathway_Homo sapiens_hsa049170.44851168
99mRNA surveillance pathway_Homo sapiens_hsa030150.44675284
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44308488
101Non-small cell lung cancer_Homo sapiens_hsa052230.44261286
102Glutamatergic synapse_Homo sapiens_hsa047240.44196152
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43822011
104Fatty acid elongation_Homo sapiens_hsa000620.42795552
105Hepatitis B_Homo sapiens_hsa051610.41926955
106Folate biosynthesis_Homo sapiens_hsa007900.40986282
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40419546
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40157319
109Insulin resistance_Homo sapiens_hsa049310.40065259
110Long-term depression_Homo sapiens_hsa047300.39846725
111Amphetamine addiction_Homo sapiens_hsa050310.39256517
112Viral carcinogenesis_Homo sapiens_hsa052030.39121076
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38917179
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38571154
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.35258393
116Ether lipid metabolism_Homo sapiens_hsa005650.34823389
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34622129
118Gastric acid secretion_Homo sapiens_hsa049710.34125680
119Oocyte meiosis_Homo sapiens_hsa041140.33676699
120Linoleic acid metabolism_Homo sapiens_hsa005910.33329058
121FoxO signaling pathway_Homo sapiens_hsa040680.32866534
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32533948
123HIF-1 signaling pathway_Homo sapiens_hsa040660.32246228
124Cardiac muscle contraction_Homo sapiens_hsa042600.31374060
125Retinol metabolism_Homo sapiens_hsa008300.29393136
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.29391959
127MAPK signaling pathway_Homo sapiens_hsa040100.29391644
128Arachidonic acid metabolism_Homo sapiens_hsa005900.29148426
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.28083186

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