IRS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of p38MAPK cascade (GO:1900745)3.87109622
2regulation of p38MAPK cascade (GO:1900744)3.61521361
3synaptic vesicle docking involved in exocytosis (GO:0016081)3.29961187
4regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.09957923
5positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.09957923
6cellular response to epinephrine stimulus (GO:0071872)3.06442501
7regulation of cholesterol homeostasis (GO:2000188)2.92582278
8cerebellar granule cell differentiation (GO:0021707)2.87442472
9regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.87318674
10positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.87318674
11ionotropic glutamate receptor signaling pathway (GO:0035235)2.81147005
12locomotory exploration behavior (GO:0035641)2.79398096
13positive regulation of histone deacetylation (GO:0031065)2.66050851
14mannose metabolic process (GO:0006013)2.65015175
15detection of molecule of bacterial origin (GO:0032490)2.63596459
16negative regulation of erythrocyte differentiation (GO:0045647)2.61786665
17cellular potassium ion homeostasis (GO:0030007)2.61469761
18growth hormone receptor signaling pathway (GO:0060396)2.60859845
19cytoskeletal anchoring at plasma membrane (GO:0007016)2.59005816
20cytoplasmic mRNA processing body assembly (GO:0033962)2.58401729
21protein targeting to Golgi (GO:0000042)2.57897090
22response to muramyl dipeptide (GO:0032495)2.57253849
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55931051
24negative regulation of cAMP-mediated signaling (GO:0043951)2.55567121
25response to epinephrine (GO:0071871)2.53958465
26synaptic vesicle maturation (GO:0016188)2.53348659
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52313816
28negative regulation of translation, ncRNA-mediated (GO:0040033)2.52313816
29regulation of translation, ncRNA-mediated (GO:0045974)2.52313816
30negative regulation of interleukin-8 production (GO:0032717)2.51339822
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.49197588
32response to lipoprotein particle (GO:0055094)2.48218687
33cellular extravasation (GO:0045123)2.43425483
34establishment of protein localization to Golgi (GO:0072600)2.42623076
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42107770
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41220281
37regulation of ARF protein signal transduction (GO:0032012)2.40618680
38cellular response to catecholamine stimulus (GO:0071870)2.39567891
39cellular response to monoamine stimulus (GO:0071868)2.39567891
40sexual reproduction (GO:0019953)2.38009171
41retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32676899
42coronary vasculature morphogenesis (GO:0060977)2.30535932
43response to monoamine (GO:0071867)2.27760740
44response to catecholamine (GO:0071869)2.27760740
45insulin-like growth factor receptor signaling pathway (GO:0048009)2.26205022
46suckling behavior (GO:0001967)2.25314405
47response to peptidoglycan (GO:0032494)2.24320270
48negative regulation of inclusion body assembly (GO:0090084)2.23404225
49potassium ion import (GO:0010107)2.23260940
50positive regulation of mRNA catabolic process (GO:0061014)2.23204831
51regulation of mRNA catabolic process (GO:0061013)2.22774779
52negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21356264
53response to corticosterone (GO:0051412)2.21328811
54glutamate receptor signaling pathway (GO:0007215)2.20782959
55nerve growth factor signaling pathway (GO:0038180)2.20550655
56cerebellar Purkinje cell differentiation (GO:0021702)2.19003829
57positive regulation of CREB transcription factor activity (GO:0032793)2.17676017
58response to dietary excess (GO:0002021)2.15827170
59cellular response to growth hormone stimulus (GO:0071378)2.15234362
60proline transport (GO:0015824)2.15106781
61cAMP catabolic process (GO:0006198)2.14573440
62synaptic vesicle exocytosis (GO:0016079)2.13664968
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.13504041
64protein localization to endosome (GO:0036010)2.12402931
65glycine transport (GO:0015816)2.11726638
66cell-cell junction maintenance (GO:0045217)2.08655622
67response to mineralocorticoid (GO:0051385)2.08356894
68myelin maintenance (GO:0043217)2.07364622
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.05885055
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.05227840
71regulation of cytokine production involved in inflammatory response (GO:1900015)2.04454906
72cell differentiation in hindbrain (GO:0021533)2.04082001
73entrainment of circadian clock by photoperiod (GO:0043153)2.04045810
74cyclic nucleotide catabolic process (GO:0009214)2.03708765
75negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.03155605
76negative regulation of glial cell proliferation (GO:0060253)2.02745073
77activation of protein kinase A activity (GO:0034199)2.02199517
78macroautophagy (GO:0016236)2.01317799
79cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.01282079
80dendrite morphogenesis (GO:0048813)2.00988033
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.00212954
82regulation of cardioblast proliferation (GO:0003264)2.00030183
83regulation of secondary heart field cardioblast proliferation (GO:0003266)2.00030183
84histone H3-K4 trimethylation (GO:0080182)1.99980436
85astrocyte differentiation (GO:0048708)1.99945449
86response to fluid shear stress (GO:0034405)1.99644419
87positive regulation of cellular amide metabolic process (GO:0034250)1.99557013
88cell migration in hindbrain (GO:0021535)1.98540943
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.98169878
90neutrophil mediated immunity (GO:0002446)1.96719760
91layer formation in cerebral cortex (GO:0021819)1.95149452
92regulation of triglyceride biosynthetic process (GO:0010866)1.94645385
93regulation of short-term neuronal synaptic plasticity (GO:0048172)1.94418478
94ovulation cycle (GO:0042698)1.93882460
95negative regulation of gluconeogenesis (GO:0045721)1.93478249
96white fat cell differentiation (GO:0050872)1.93374600
97neuronal ion channel clustering (GO:0045161)1.91936226
98regulation of axon extension involved in axon guidance (GO:0048841)1.90527163
99regulation of synaptic vesicle exocytosis (GO:2000300)1.90112118
100negative regulation of Rho protein signal transduction (GO:0035024)1.89782194
101positive regulation of oligodendrocyte differentiation (GO:0048714)1.89596819
102cerebellar Purkinje cell layer development (GO:0021680)1.89459095
103dermatan sulfate metabolic process (GO:0030205)1.89400542
104myelination in peripheral nervous system (GO:0022011)1.89398175
105peripheral nervous system axon ensheathment (GO:0032292)1.89398175
106phagocytosis, recognition (GO:0006910)1.89364712
107endothelial cell chemotaxis (GO:0035767)1.88512969
108regulation of interleukin-12 biosynthetic process (GO:0045075)1.88126655
109neuron projection regeneration (GO:0031102)1.87990043
110positive regulation of glomerulus development (GO:0090193)1.87973130
111platelet-derived growth factor receptor signaling pathway (GO:0048008)1.87216732
112peptidyl-tyrosine autophosphorylation (GO:0038083)1.85985450
113L-amino acid import (GO:0043092)1.85752349
114sodium ion export (GO:0071436)1.85690773
115neuron maturation (GO:0042551)1.84918596
116regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)1.84813147
117relaxation of cardiac muscle (GO:0055119)1.84590662
118regulation of ARF GTPase activity (GO:0032312)1.84102180
119G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.83542333
120regulation of respiratory gaseous exchange (GO:0043576)1.83319367
121negative regulation of catenin import into nucleus (GO:0035414)1.83054299
122mating behavior (GO:0007617)1.82843554
123regulation of synaptic vesicle transport (GO:1902803)1.82718714
124regulation of neuronal synaptic plasticity (GO:0048168)1.82552063
125regulation of beta-amyloid formation (GO:1902003)1.82437232
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.82343878
127positive regulation of Rap GTPase activity (GO:0032854)1.82159266
128regulation of synapse structural plasticity (GO:0051823)1.81725915
129urinary tract smooth muscle contraction (GO:0014848)1.81589943
130skeletal muscle cell differentiation (GO:0035914)1.81465445
131response to isoquinoline alkaloid (GO:0014072)1.81403773
132positive regulation of astrocyte differentiation (GO:0048711)1.81197158
133interleukin-1-mediated signaling pathway (GO:0070498)1.81087267
134axonal fasciculation (GO:0007413)1.80735647
135macrophage activation (GO:0042116)1.79871078
136dermatan sulfate biosynthetic process (GO:0030208)1.79856477
137branching involved in labyrinthine layer morphogenesis (GO:0060670)1.79743915
138response to laminar fluid shear stress (GO:0034616)1.79684839
139synaptic transmission, glutamatergic (GO:0035249)1.79430032
140polarized epithelial cell differentiation (GO:0030859)1.79214613
141membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.78420225
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.78149855
143negative regulation of neurotransmitter transport (GO:0051589)1.78036638
144hemidesmosome assembly (GO:0031581)1.77003216
145innervation (GO:0060384)1.76384354
146vesicle transport along microtubule (GO:0047496)1.75995430
147dendritic spine morphogenesis (GO:0060997)1.75983637
148regulation of NFAT protein import into nucleus (GO:0051532)1.75919327
149cellular response to fluid shear stress (GO:0071498)1.75710481
150* negative regulation of fatty acid transport (GO:2000192)1.75691009
151epithelial cell fate commitment (GO:0072148)1.75493878
152stress fiber assembly (GO:0043149)1.74739910
153regulation of histone deacetylation (GO:0031063)1.74209276
154alanine transport (GO:0032328)1.72545090
155exploration behavior (GO:0035640)1.71936985
156entrainment of circadian clock (GO:0009649)1.71233741
157dopaminergic neuron differentiation (GO:0071542)1.71140831
158enteric nervous system development (GO:0048484)1.71064931
159asymmetric protein localization (GO:0008105)1.70995924
160positive regulation of glial cell differentiation (GO:0045687)1.70699872
161negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.69535451
162regulation of amyloid precursor protein catabolic process (GO:1902991)1.69413084
163photoperiodism (GO:0009648)1.69036270
164apical protein localization (GO:0045176)1.68856315
165regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.68408583
166camera-type eye morphogenesis (GO:0048593)1.68153718
167* positive regulation of glycogen biosynthetic process (GO:0045725)1.67967713
168ER overload response (GO:0006983)1.67877058
169glutamate secretion (GO:0014047)1.67114031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.46945487
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34850986
3ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03869183
4* ESR2_21235772_ChIP-Seq_MCF-7_Human1.86310155
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80537618
6STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79705396
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76300682
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74281760
9KDM2B_26808549_Chip-Seq_K562_Human1.73932879
10EGR1_19374776_ChIP-ChIP_THP-1_Human1.73120054
11EZH2_22144423_ChIP-Seq_EOC_Human1.69018052
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.68693062
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64598944
14DROSHA_22980978_ChIP-Seq_HELA_Human1.64531716
15* ESR1_21235772_ChIP-Seq_MCF-7_Human1.62580227
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60755203
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60753785
18GBX2_23144817_ChIP-Seq_PC3_Human1.58534462
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56174098
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55342377
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55342377
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51017675
23CLOCK_20551151_ChIP-Seq_293T_Human1.49865854
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48245424
25AHR_22903824_ChIP-Seq_MCF-7_Human1.47632701
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47563543
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46205544
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43924621
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.43546104
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42968875
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41352863
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.40057982
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38438190
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37770737
35KDM2B_26808549_Chip-Seq_DND41_Human1.36307229
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36234409
37WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35662913
38AR_21572438_ChIP-Seq_LNCaP_Human1.35245478
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34626604
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34251393
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33420720
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.30694469
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30421325
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29088204
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28104573
46TP53_16413492_ChIP-PET_HCT116_Human1.27498371
47* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26049949
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.25775390
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24395467
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23698776
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23449814
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.22588188
53REST_21632747_ChIP-Seq_MESCs_Mouse1.21930470
54* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21811589
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21375116
56* RARB_27405468_Chip-Seq_BRAIN_Mouse1.20816396
57GATA1_19941826_ChIP-Seq_K562_Human1.20734321
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18726923
59TCF7_22412390_ChIP-Seq_EML_Mouse1.18233031
60* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18121733
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.17887407
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17416111
63* VDR_24763502_ChIP-Seq_THP-1_Human1.16486237
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14708172
65* VDR_21846776_ChIP-Seq_THP-1_Human1.14401267
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13746235
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13633620
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.13029746
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12973680
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11068358
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.11033205
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09822861
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.09699875
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09530309
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09284095
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07885683
77* PIAS1_25552417_ChIP-Seq_VCAP_Human1.07840256
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.06128181
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05955547
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.05878622
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.05456824
82TP53_18474530_ChIP-ChIP_U2OS_Human1.05165264
83* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04536217
84* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04069468
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03483439
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02929834
87* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02099538
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00938605
89* KLF5_25053715_ChIP-Seq_YYC3_Human1.00671558
90LXR_22292898_ChIP-Seq_THP-1_Human1.00375523
91RUNX_20019798_ChIP-Seq_JUKART_Human0.99482698
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.97990165
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.97828173
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97773210
95* RXR_22108803_ChIP-Seq_LS180_Human0.97520081
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97289582
97* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97214740
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97049904
99* VDR_24787735_ChIP-Seq_THP-1_Human0.96697584
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95932356
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95637624
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95192639
103* LXR_22158963_ChIP-Seq_LIVER_Mouse0.95081824
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94417406
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.94160333
106CJUN_26792858_Chip-Seq_BT549_Human0.94074145
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93696717
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93610711
109CREB1_26743006_Chip-Seq_LNCaP_Human0.92276040
110CBX2_27304074_Chip-Seq_ESCs_Mouse0.92262578
111* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92246601
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92134558
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.91978987
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.91380118
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.91326546
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91134195
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.90376218
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89697225
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89628000
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88440185
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86345739
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85644012
123* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81827339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.58888861
2MP0008961_abnormal_basal_metabolism3.29426408
3MP0004510_myositis2.95703058
4MP0002254_reproductive_system_inflammat2.82783011
5MP0003300_gastrointestinal_ulcer2.73191151
6MP0009780_abnormal_chondrocyte_physiolo2.62818160
7MP0004858_abnormal_nervous_system2.51944220
8MP0003303_peritoneal_inflammation2.45956305
9MP0003045_fibrosis2.39935993
10MP0002909_abnormal_adrenal_gland2.35476063
11MP0005171_absent_coat_pigmentation2.32986690
12MP0005409_darkened_coat_color2.16150006
13MP0000003_abnormal_adipose_tissue2.14957367
14MP0001501_abnormal_sleep_pattern2.14323820
15MP0004859_abnormal_synaptic_plasticity2.07679571
16* MP0005076_abnormal_cell_differentiation1.96013211
17MP0001502_abnormal_circadian_rhythm1.84680113
18MP0005503_abnormal_tendon_morphology1.83107141
19MP0003705_abnormal_hypodermis_morpholog1.78784546
20MP0003453_abnormal_keratinocyte_physiol1.71665265
21MP0008438_abnormal_cutaneous_collagen1.69911933
22MP0003122_maternal_imprinting1.68981174
23MP0003879_abnormal_hair_cell1.68313391
24MP0003279_aneurysm1.58939401
25MP0001299_abnormal_eye_distance/1.55821247
26MP0005375_adipose_tissue_phenotype1.55175242
27MP0000013_abnormal_adipose_tissue1.52398225
28MP0004270_analgesia1.47302664
29MP0005174_abnormal_tail_pigmentation1.46245467
30MP0010234_abnormal_vibrissa_follicle1.44085163
31MP0009278_abnormal_bone_marrow1.43508800
32MP0000569_abnormal_digit_pigmentation1.42686487
33MP0009379_abnormal_foot_pigmentation1.41787098
34MP0001970_abnormal_pain_threshold1.39184875
35MP0003566_abnormal_cell_adhesion1.38312869
36MP0005645_abnormal_hypothalamus_physiol1.36989505
37MP0001486_abnormal_startle_reflex1.35912412
38MP0002272_abnormal_nervous_system1.35611123
39MP0003075_altered_response_to1.34875738
40MP0003011_delayed_dark_adaptation1.33723563
41MP0003183_abnormal_peptide_metabolism1.33313558
42MP0010352_gastrointestinal_tract_polyps1.32427590
43MP0003635_abnormal_synaptic_transmissio1.28780495
44MP0002735_abnormal_chemical_nociception1.27630148
45MP0003283_abnormal_digestive_organ1.27033541
46MP0002896_abnormal_bone_mineralization1.26771847
47MP0004381_abnormal_hair_follicle1.24704118
48MP0001968_abnormal_touch/_nociception1.23259356
49MP0001177_atelectasis1.21787581
50MP0002653_abnormal_ependyma_morphology1.21506345
51MP0003172_abnormal_lysosome_physiology1.19984974
52MP0004264_abnormal_extraembryonic_tissu1.19748772
53MP0003787_abnormal_imprinting1.18965782
54MP0005623_abnormal_meninges_morphology1.18900167
55MP0002733_abnormal_thermal_nociception1.18607281
56MP0003690_abnormal_glial_cell1.15724635
57MP0002638_abnormal_pupillary_reflex1.15019532
58MP0008569_lethality_at_weaning1.14394531
59MP0005275_abnormal_skin_tensile1.13874296
60MP0004885_abnormal_endolymph1.12796899
61MP0002971_abnormal_brown_adipose1.11253606
62MP0004185_abnormal_adipocyte_glucose1.09613337
63MP0000762_abnormal_tongue_morphology1.08392770
64MP0002138_abnormal_hepatobiliary_system1.08052833
65MP0004130_abnormal_muscle_cell1.08010035
66MP0002168_other_aberrant_phenotype1.07377975
67MP0003880_abnormal_central_pattern1.06831373
68MP0003091_abnormal_cell_migration1.06766641
69MP0000733_abnormal_muscle_development1.04866330
70MP0001188_hyperpigmentation1.02968140
71MP0002060_abnormal_skin_morphology1.00370179
72MP0002998_abnormal_bone_remodeling1.00180015
73MP0002734_abnormal_mechanical_nocicepti0.99780377
74MP0005535_abnormal_body_temperature0.98655879
75* MP0005164_abnormal_response_to0.98590530
76MP0001346_abnormal_lacrimal_gland0.98589559
77MP0000678_abnormal_parathyroid_gland0.98208371
78MP0002133_abnormal_respiratory_system0.96381145
79MP0005388_respiratory_system_phenotype0.96381145
80MP0001340_abnormal_eyelid_morphology0.96024283
81MP0001958_emphysema0.95508740
82MP0005257_abnormal_intraocular_pressure0.95424929
83MP0001851_eye_inflammation0.94525008
84MP0002234_abnormal_pharynx_morphology0.93975161
85MP0000778_abnormal_nervous_system0.93809602
86MP0000920_abnormal_myelination0.93197151
87MP0002063_abnormal_learning/memory/cond0.93067061
88* MP0005595_abnormal_vascular_smooth0.92537297
89MP0003436_decreased_susceptibility_to0.91386144
90MP0000534_abnormal_ureter_morphology0.91156477
91MP0003828_pulmonary_edema0.90131318
92MP0005390_skeleton_phenotype0.90060941
93* MP0004883_abnormal_blood_vessel0.89656233
94MP0004742_abnormal_vestibular_system0.89320545
95MP0001440_abnormal_grooming_behavior0.87959840
96MP0004947_skin_inflammation0.87770882
97MP0002064_seizures0.87655671
98MP0003724_increased_susceptibility_to0.86912210
99MP0003329_amyloid_beta_deposits0.86891943
100* MP0001944_abnormal_pancreas_morphology0.86747159
101MP0009745_abnormal_behavioral_response0.86389095
102MP0005248_abnormal_Harderian_gland0.86303259
103MP0002822_catalepsy0.85519719
104MP0002295_abnormal_pulmonary_circulatio0.85449435
105MP0000955_abnormal_spinal_cord0.85440506
106MP0003634_abnormal_glial_cell0.85399628
107MP0002933_joint_inflammation0.84445603
108MP0000467_abnormal_esophagus_morphology0.84283817
109MP0005666_abnormal_adipose_tissue0.84093820
110MP0002009_preneoplasia0.83976253
111MP0002067_abnormal_sensory_capabilities0.82827950
112MP0004484_altered_response_of0.82084464
113MP0003942_abnormal_urinary_system0.80752266
114MP0008004_abnormal_stomach_pH0.80240949
115MP0004043_abnormal_pH_regulation0.79910038
116MP0005670_abnormal_white_adipose0.79471229
117MP0010678_abnormal_skin_adnexa0.79227782
118MP0000015_abnormal_ear_pigmentation0.79174866
119MP0001849_ear_inflammation0.78859887
120MP0009115_abnormal_fat_cell0.78161798
121MP0003115_abnormal_respiratory_system0.76955624
122MP0005423_abnormal_somatic_nervous0.76866598
123MP0003631_nervous_system_phenotype0.74052170
124MP0005508_abnormal_skeleton_morphology0.73008855
125* MP0002557_abnormal_social/conspecific_i0.72973488
126MP0002572_abnormal_emotion/affect_behav0.72931870
127MP0005387_immune_system_phenotype0.72750447
128MP0001790_abnormal_immune_system0.72750447
129MP0006138_congestive_heart_failure0.71738883
130MP0004924_abnormal_behavior0.71104455
131MP0005386_behavior/neurological_phenoty0.71104455
132MP0004811_abnormal_neuron_physiology0.71094117
133* MP0002693_abnormal_pancreas_physiology0.70974767
134MP0004272_abnormal_basement_membrane0.70512929
135* MP0002078_abnormal_glucose_homeostasis0.70371447
136MP0002928_abnormal_bile_duct0.69864948
137MP0009053_abnormal_anal_canal0.69263552
138MP0001348_abnormal_lacrimal_gland0.69154081
139MP0001881_abnormal_mammary_gland0.68992962
140MP0001270_distended_abdomen0.68900888
141* MP0005334_abnormal_fat_pad0.68792538
142MP0002108_abnormal_muscle_morphology0.67635646
143MP0003633_abnormal_nervous_system0.66653088
144MP0003632_abnormal_nervous_system0.65494436
145MP0001533_abnormal_skeleton_physiology0.64730361

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33011686
2Macroorchidism (HP:0000053)3.21148251
3Persistence of primary teeth (HP:0006335)2.96778144
4Broad face (HP:0000283)2.96759511
5Turricephaly (HP:0000262)2.87777989
6Amyloidosis (HP:0011034)2.84385369
7Sleep apnea (HP:0010535)2.69765419
8Shallow orbits (HP:0000586)2.64076906
9Abnormality of the nasal septum (HP:0000419)2.60142913
10Hypercortisolism (HP:0001578)2.57597522
11Aplasia involving bones of the upper limbs (HP:0009823)2.48382162
12Aplasia of the phalanges of the hand (HP:0009802)2.48382162
13Aplasia involving bones of the extremities (HP:0009825)2.48382162
14Bronchomalacia (HP:0002780)2.46917694
15Abnormality of binocular vision (HP:0011514)2.37782695
16Diplopia (HP:0000651)2.37782695
17Cerebral aneurysm (HP:0004944)2.35323853
18Abnormality of incisor morphology (HP:0011063)2.25360557
19Febrile seizures (HP:0002373)2.24064130
20Lower limb amyotrophy (HP:0007210)2.23372905
21Increased density of long bones (HP:0006392)2.18659938
22Mild short stature (HP:0003502)2.17374929
23Abnormality of calcium-phosphate metabolism (HP:0100530)2.16130864
24Action tremor (HP:0002345)2.15912831
25Supranuclear gaze palsy (HP:0000605)2.14334941
26Cerebral inclusion bodies (HP:0100314)2.14069817
27Focal motor seizures (HP:0011153)2.10368609
28Choroideremia (HP:0001139)2.07611830
29Arthropathy (HP:0003040)2.07243085
30Neurofibrillary tangles (HP:0002185)2.05253225
31Hypoventilation (HP:0002791)2.05118490
32Absent frontal sinuses (HP:0002688)2.02607260
33Hemiplegia (HP:0002301)2.02432047
34Annular pancreas (HP:0001734)2.01843090
35Progressive cerebellar ataxia (HP:0002073)2.01373964
36Lip pit (HP:0100267)2.01211946
37Protrusio acetabuli (HP:0003179)2.00409267
38Neonatal short-limb short stature (HP:0008921)1.99373593
39Genu recurvatum (HP:0002816)1.98984074
40Myocardial infarction (HP:0001658)1.98174755
41Agitation (HP:0000713)1.98171871
42Hypoplasia of the iris (HP:0007676)1.97925689
43Aqueductal stenosis (HP:0002410)1.93343457
44Wormian bones (HP:0002645)1.92056318
45Vertebral arch anomaly (HP:0008438)1.91442419
46Genetic anticipation (HP:0003743)1.91159115
47Myokymia (HP:0002411)1.90464394
48Broad metatarsal (HP:0001783)1.90009880
49Mitral regurgitation (HP:0001653)1.89648435
50Disproportionate tall stature (HP:0001519)1.87668490
51Hypoplastic labia majora (HP:0000059)1.87516207
52Epileptic encephalopathy (HP:0200134)1.86875811
53Mitral valve prolapse (HP:0001634)1.83970948
54Striae distensae (HP:0001065)1.83965591
55Distal lower limb amyotrophy (HP:0008944)1.83695245
56Peritonitis (HP:0002586)1.83538024
57Hyperglycemia (HP:0003074)1.82570051
58Blue irides (HP:0000635)1.82485037
59Atonic seizures (HP:0010819)1.82480415
60Megalencephaly (HP:0001355)1.82388452
61Facial shape deformation (HP:0011334)1.82024144
62Potter facies (HP:0002009)1.82024144
63Interstitial pulmonary disease (HP:0006530)1.81841664
64Enlarged penis (HP:0000040)1.81538300
65Hyporeflexia of lower limbs (HP:0002600)1.81236959
66Abnormality of the 2nd finger (HP:0004100)1.80772663
67Hyperventilation (HP:0002883)1.80661030
68Obstructive sleep apnea (HP:0002870)1.80266399
69Abnormality of the parietal bone (HP:0002696)1.79914852
70Failure to thrive in infancy (HP:0001531)1.77512189
71Stomach cancer (HP:0012126)1.76582435
72Increased CSF protein (HP:0002922)1.76397445
73Vitreoretinal degeneration (HP:0000655)1.75322632
74Arterial tortuosity (HP:0005116)1.74428169
75Thin bony cortex (HP:0002753)1.74277704
76Vascular tortuosity (HP:0004948)1.73624263
77Round face (HP:0000311)1.72106839
78Postural instability (HP:0002172)1.71714891
79Alacrima (HP:0000522)1.71121813
80Buphthalmos (HP:0000557)1.70158817
81Episodic fever (HP:0001954)1.70121987
82Mildly elevated creatine phosphokinase (HP:0008180)1.69651788
83Thickened helices (HP:0000391)1.69528874
84Hyperextensible skin (HP:0000974)1.68968452
85Lower limb asymmetry (HP:0100559)1.68931536
86Hyperparathyroidism (HP:0000843)1.68831169
87Narrow palate (HP:0000189)1.68757915
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.68664847
89Spondylolisthesis (HP:0003302)1.68492403
90Global brain atrophy (HP:0002283)1.68375715
91Coronal craniosynostosis (HP:0004440)1.68132278
92Wide anterior fontanel (HP:0000260)1.68072042
93Aneurysm (HP:0002617)1.67995302
94Hyperinsulinemic hypoglycemia (HP:0000825)1.67661196
95Aortic regurgitation (HP:0001659)1.67504345
96Supernumerary ribs (HP:0005815)1.67456955
97Hypoplastic ischia (HP:0003175)1.67346450
98Tracheomalacia (HP:0002779)1.66924610
99Peripheral hypomyelination (HP:0007182)1.66714084
100Prolonged QT interval (HP:0001657)1.66530081
101Abnormal eating behavior (HP:0100738)1.66230512
102Papilledema (HP:0001085)1.64781677
103Ocular albinism (HP:0001107)1.64495949
104Onion bulb formation (HP:0003383)1.64345625
105Cervical subluxation (HP:0003308)1.64190029
106Fragile skin (HP:0001030)1.63664423
107Abnormality of the ischium (HP:0003174)1.63214143
108Insomnia (HP:0100785)1.62507069
109Hypoplasia of the maxilla (HP:0000327)1.62166749
110Muscle fiber splitting (HP:0003555)1.62022261
111Long palpebral fissure (HP:0000637)1.61881809
112Truncal ataxia (HP:0002078)1.61847057
113Laryngomalacia (HP:0001601)1.61809598
114Labial hypoplasia (HP:0000066)1.61392327
115Milia (HP:0001056)1.61343708
116Abnormality of secondary sexual hair (HP:0009888)1.60823055
117Abnormality of the axillary hair (HP:0100134)1.60823055
118Abnormality of the labia majora (HP:0012881)1.60297442
119Arnold-Chiari malformation (HP:0002308)1.59697025
120Oligodontia (HP:0000677)1.59507578
121Abnormality of endocrine pancreas physiology (HP:0012093)1.58969616
122Abnormality of the pancreatic islet cells (HP:0006476)1.58969616
123Supernumerary nipples (HP:0002558)1.57418113
124Tibial bowing (HP:0002982)1.55817348
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55479289
126Dislocated radial head (HP:0003083)1.55443703
127Urethral obstruction (HP:0000796)1.54174541
128Supernumerary bones of the axial skeleton (HP:0009144)1.54133973
129Narrow nasal bridge (HP:0000446)1.52835681
130Eczematoid dermatitis (HP:0000976)1.51989168
131Achilles tendon contracture (HP:0001771)1.50120481
132Congenital glaucoma (HP:0001087)1.49707970
133Segmental peripheral demyelination/remyelination (HP:0003481)1.49544144
134Ulnar bowing (HP:0003031)1.49530356
135Anteriorly placed anus (HP:0001545)1.49495360
136Focal seizures (HP:0007359)1.48991253
137Acanthosis nigricans (HP:0000956)1.48590279
138Abnormality of the fingertips (HP:0001211)1.47490621
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.47094919
140Abnormality of the corticospinal tract (HP:0002492)1.46541764
141Ankyloglossia (HP:0010296)1.46321953
142Scapular winging (HP:0003691)1.45131065
143Pheochromocytoma (HP:0002666)1.44951082
144Growth hormone excess (HP:0000845)1.44578450
145Abnormality of the distal phalanges of the toes (HP:0010182)1.43988246
146Menstrual irregularities (HP:0000858)1.43129390
147Hepatoblastoma (HP:0002884)1.43009332
148Mitral stenosis (HP:0001718)1.42744151
149Atrophic scars (HP:0001075)1.42412014
150Abnormality of the gastric mucosa (HP:0004295)1.42272754
151Pancreatic islet-cell hyperplasia (HP:0004510)1.42179354
152Ulnar claw (HP:0001178)1.42150896
153Broad thumb (HP:0011304)1.41998405
154Hyperkalemia (HP:0002153)1.41865324
155Overgrowth (HP:0001548)1.41700868
156Hypoplasia of dental enamel (HP:0006297)1.40867405
157Upper limb amyotrophy (HP:0009129)1.40221986
158Distal upper limb amyotrophy (HP:0007149)1.40221986
159Aortic aneurysm (HP:0004942)1.39536631
160Difficulty running (HP:0009046)1.39513971
161Hyperacusis (HP:0010780)1.38165886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB12.90972141
2MAPK152.84390936
3PRPF4B2.70544241
4EPHA32.59890169
5TRIB32.41530348
6MAP3K22.37327794
7SIK12.12110330
8MAP3K92.02751064
9IRAK21.88094996
10RIPK11.78091145
11HIPK21.77386777
12PRKD31.71194264
13MAP3K101.66663444
14BLK1.64506292
15NTRK11.63893187
16CDK121.60973264
17FGFR21.60712908
18CAMK1G1.58469437
19AKT31.57622357
20PTK21.53665858
21TNK21.48640526
22PTK61.44547263
23MAPK121.43357923
24MARK11.39744159
25RET1.37036315
26ERN11.36986707
27DMPK1.35393971
28LATS21.34288675
29NTRK31.32983823
30LATS11.32158222
31FGFR41.31772591
32MAP2K31.30977621
33PDGFRA1.28848582
34FGFR31.27108867
35CHUK1.27021854
36ALK1.26409983
37DAPK21.25552990
38TAOK31.21126180
39CAMK1D1.19776694
40BMX1.18019857
41INSRR1.16812935
42MAPKAPK51.16244179
43JAK11.14192726
44MAP3K11.11570444
45MAP3K61.06564183
46SGK31.06506990
47CAMK11.05816704
48LMTK21.05359039
49TYRO31.03152816
50MAP2K21.00686585
51FER0.98696474
52PRKCH0.98087936
53STK380.95862916
54WNK10.95620893
55GRK60.95237409
56TRPM70.93649951
57MOS0.90987696
58CASK0.90447605
59RPS6KA20.88598101
60MAP3K140.88088274
61MAP3K30.87951006
62KSR20.86520499
63PKN10.83909729
64TTN0.83724942
65SIK20.83077239
66* MTOR0.82389273
67FRK0.81615955
68MAP3K130.81005356
69SGK4940.80800059
70SGK2230.80800059
71CDC42BPA0.80698420
72UHMK10.80239581
73STK110.79269140
74IRAK40.78632575
75PDK20.77369221
76PNCK0.77191836
77* PDGFRB0.76460204
78PAK60.74004945
79PDK10.73865168
80ICK0.73477006
81IKBKB0.73391706
82MAP3K70.73233869
83MARK20.72501275
84EPHA40.70813893
85PAK30.69548975
86* GSK3A0.67236834
87MET0.67187435
88PRKD10.66819460
89NTRK20.65563402
90ITK0.65482277
91DDR20.63038864
92MAP2K40.61879453
93CDK50.60811971
94PRKAA20.60523040
95CDK90.60223343
96JAK20.60095002
97YES10.60064486
98ZAP700.59874129
99RIPK40.59713534
100DYRK1A0.59279344
101SGK20.59070435
102NLK0.58921008
103TAOK10.58643273
104PDPK10.57792410
105DYRK1B0.57197372
106IRAK10.56927283
107MAP3K40.55771025
108CDK60.55014807
109MAPK70.54708196
110NEK60.54181000
111MAPK40.54027385
112PRKD20.53845220
113RPS6KL10.53718153
114RPS6KC10.53718153
115EPHB20.53009034
116SGK10.52954918
117RPS6KA60.51821325
118PAK20.51587596
119CAMK40.51344614
120RPS6KA10.51277197
121IRAK30.51231815
122PTK2B0.50347728
123HCK0.50250685
124WNK40.49554642
125CAMK2B0.48135288
126CAMKK10.46929128
127FES0.46874229
128EEF2K0.46133854
129FGFR10.43000691
130MAPK100.42886302
131GRK50.41150772
132MAP2K10.40804430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009101.77450237
2* Type II diabetes mellitus_Homo sapiens_hsa049301.61577133
3Nicotine addiction_Homo sapiens_hsa050331.61240552
4Dorso-ventral axis formation_Homo sapiens_hsa043201.59313966
5Cocaine addiction_Homo sapiens_hsa050301.50075411
6Insulin secretion_Homo sapiens_hsa049111.45338879
7* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45064764
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44274922
9Notch signaling pathway_Homo sapiens_hsa043301.34454168
10Estrogen signaling pathway_Homo sapiens_hsa049151.33714050
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24203025
12Osteoclast differentiation_Homo sapiens_hsa043801.22483516
13Amphetamine addiction_Homo sapiens_hsa050311.20304905
14Circadian rhythm_Homo sapiens_hsa047101.19455185
15Renin secretion_Homo sapiens_hsa049241.18507541
16Circadian entrainment_Homo sapiens_hsa047131.17952558
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17569311
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15256341
19Gastric acid secretion_Homo sapiens_hsa049711.14013947
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.13348041
21Prolactin signaling pathway_Homo sapiens_hsa049171.12920132
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.11123005
23Cholinergic synapse_Homo sapiens_hsa047251.10034292
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08494562
25Renal cell carcinoma_Homo sapiens_hsa052111.08113702
26GnRH signaling pathway_Homo sapiens_hsa049121.07305695
27Glioma_Homo sapiens_hsa052141.06028575
28Long-term depression_Homo sapiens_hsa047301.04998508
29* Insulin resistance_Homo sapiens_hsa049311.03493027
30Salivary secretion_Homo sapiens_hsa049701.02488271
31Long-term potentiation_Homo sapiens_hsa047201.01886003
32MAPK signaling pathway_Homo sapiens_hsa040100.99699521
33B cell receptor signaling pathway_Homo sapiens_hsa046620.99637283
34ErbB signaling pathway_Homo sapiens_hsa040120.98120903
35Melanogenesis_Homo sapiens_hsa049160.98044447
36Chronic myeloid leukemia_Homo sapiens_hsa052200.97619004
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95206159
38Axon guidance_Homo sapiens_hsa043600.94884694
39Ovarian steroidogenesis_Homo sapiens_hsa049130.94147058
40cAMP signaling pathway_Homo sapiens_hsa040240.93891899
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93291861
42Proteoglycans in cancer_Homo sapiens_hsa052050.91171826
43GABAergic synapse_Homo sapiens_hsa047270.90758074
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89235879
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88681629
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88504829
47Endometrial cancer_Homo sapiens_hsa052130.88476175
48Dopaminergic synapse_Homo sapiens_hsa047280.87632011
49Prion diseases_Homo sapiens_hsa050200.87252473
50Calcium signaling pathway_Homo sapiens_hsa040200.86781628
51* Adipocytokine signaling pathway_Homo sapiens_hsa049200.86164429
52Oxytocin signaling pathway_Homo sapiens_hsa049210.85857782
53Glutamatergic synapse_Homo sapiens_hsa047240.85723369
54Bladder cancer_Homo sapiens_hsa052190.85442228
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.84651311
56TNF signaling pathway_Homo sapiens_hsa046680.83855499
57Dilated cardiomyopathy_Homo sapiens_hsa054140.83840314
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82160611
59* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80562984
60Focal adhesion_Homo sapiens_hsa045100.79961219
61mTOR signaling pathway_Homo sapiens_hsa041500.79487854
62Morphine addiction_Homo sapiens_hsa050320.78765327
63Amoebiasis_Homo sapiens_hsa051460.78190861
64Gap junction_Homo sapiens_hsa045400.77833854
65Synaptic vesicle cycle_Homo sapiens_hsa047210.77515339
66T cell receptor signaling pathway_Homo sapiens_hsa046600.77381102
67Non-small cell lung cancer_Homo sapiens_hsa052230.77321998
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77099925
69Adherens junction_Homo sapiens_hsa045200.76754423
70Acute myeloid leukemia_Homo sapiens_hsa052210.76437548
71Glucagon signaling pathway_Homo sapiens_hsa049220.74064253
72Inositol phosphate metabolism_Homo sapiens_hsa005620.74054699
73Pancreatic cancer_Homo sapiens_hsa052120.73359863
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73157533
75Hippo signaling pathway_Homo sapiens_hsa043900.72146737
76* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72067763
77Olfactory transduction_Homo sapiens_hsa047400.71703500
78Ras signaling pathway_Homo sapiens_hsa040140.70797225
79Hedgehog signaling pathway_Homo sapiens_hsa043400.70156576
80Choline metabolism in cancer_Homo sapiens_hsa052310.69670907
81Chemokine signaling pathway_Homo sapiens_hsa040620.69431722
82Prostate cancer_Homo sapiens_hsa052150.69104177
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68167814
84Basal cell carcinoma_Homo sapiens_hsa052170.67023396
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66904368
86* FoxO signaling pathway_Homo sapiens_hsa040680.66770724
87* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66346148
88Thyroid hormone synthesis_Homo sapiens_hsa049180.66001440
89Toxoplasmosis_Homo sapiens_hsa051450.65826513
90Wnt signaling pathway_Homo sapiens_hsa043100.65777826
91Bile secretion_Homo sapiens_hsa049760.64280667
92VEGF signaling pathway_Homo sapiens_hsa043700.63979869
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63876138
94Platelet activation_Homo sapiens_hsa046110.63355766
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63125609
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62875591
97Pancreatic secretion_Homo sapiens_hsa049720.62705842
98Rap1 signaling pathway_Homo sapiens_hsa040150.62117793
99* AMPK signaling pathway_Homo sapiens_hsa041520.62102656
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61773290
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61064946
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.60952670
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60634545
104Melanoma_Homo sapiens_hsa052180.60431110
105* Insulin signaling pathway_Homo sapiens_hsa049100.60282537
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.59720201
107Endocytosis_Homo sapiens_hsa041440.59540279
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59279079
109ECM-receptor interaction_Homo sapiens_hsa045120.59247917
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.58905082
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.58793874
112Serotonergic synapse_Homo sapiens_hsa047260.58642843
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58137689
114Lysine degradation_Homo sapiens_hsa003100.57459786
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57243282
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.56427885
117Fatty acid biosynthesis_Homo sapiens_hsa000610.53879788
118Protein digestion and absorption_Homo sapiens_hsa049740.52946639
119* MicroRNAs in cancer_Homo sapiens_hsa052060.51242694

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