IRF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23546961
2negative regulation of cell killing (GO:0031342)5.23546961
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.91579594
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.91579594
5thymic T cell selection (GO:0045061)4.44858139
6ribosomal small subunit assembly (GO:0000028)4.40641299
7antigen processing and presentation of endogenous antigen (GO:0019883)4.39494490
8L-phenylalanine metabolic process (GO:0006558)4.20761139
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20761139
10viral transcription (GO:0019083)4.14579995
11negative thymic T cell selection (GO:0045060)4.10606654
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02554135
13L-phenylalanine catabolic process (GO:0006559)4.02554135
14negative T cell selection (GO:0043383)3.98146643
15detection of bacterium (GO:0016045)3.92691862
16translational termination (GO:0006415)3.88410652
17T cell selection (GO:0045058)3.85180403
18mannose metabolic process (GO:0006013)3.83241092
19* positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.81106326
20leukocyte aggregation (GO:0070486)3.69334723
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.66197355
22modulation by symbiont of host immune response (GO:0052553)3.66197355
23positive regulation by symbiont of host defense response (GO:0052509)3.66197355
24modulation by symbiont of host defense response (GO:0052031)3.66197355
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66197355
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66197355
27detection of other organism (GO:0098543)3.65886732
28aromatic amino acid family catabolic process (GO:0009074)3.64143274
29B cell receptor signaling pathway (GO:0050853)3.61308831
30NIK/NF-kappaB signaling (GO:0038061)3.61185187
31positive regulation of gamma-delta T cell activation (GO:0046645)3.58831780
32regulation of B cell receptor signaling pathway (GO:0050855)3.55180301
33positive T cell selection (GO:0043368)3.54291144
34immunoglobulin mediated immune response (GO:0016064)3.53120016
35regulation of gamma-delta T cell differentiation (GO:0045586)3.48759869
36sulfur amino acid catabolic process (GO:0000098)3.48499555
37response to muramyl dipeptide (GO:0032495)3.42043393
38translational elongation (GO:0006414)3.42010736
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40639490
40tryptophan catabolic process (GO:0006569)3.39330731
41indole-containing compound catabolic process (GO:0042436)3.39330731
42indolalkylamine catabolic process (GO:0046218)3.39330731
43valine metabolic process (GO:0006573)3.37221144
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36841533
45cysteine metabolic process (GO:0006534)3.33647803
46protein targeting to ER (GO:0045047)3.30316454
47cotranslational protein targeting to membrane (GO:0006613)3.28136195
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.27812054
49tolerance induction (GO:0002507)3.26160084
50kynurenine metabolic process (GO:0070189)3.25681924
51response to interleukin-15 (GO:0070672)3.23403489
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.22937850
53regulation of B cell differentiation (GO:0045577)3.22239840
54glyoxylate metabolic process (GO:0046487)3.22148354
55* response to type I interferon (GO:0034340)3.21844682
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21256575
57tryptophan metabolic process (GO:0006568)3.20090843
58negative regulation of innate immune response (GO:0045824)3.19535709
59ribosomal small subunit biogenesis (GO:0042274)3.15666555
60alpha-linolenic acid metabolic process (GO:0036109)3.15040061
61* cellular response to type I interferon (GO:0071357)3.14967352
62* type I interferon signaling pathway (GO:0060337)3.14967352
63urea cycle (GO:0000050)3.14719820
64urea metabolic process (GO:0019627)3.14719820
65glycine metabolic process (GO:0006544)3.14685802
66bile acid biosynthetic process (GO:0006699)3.14424066
67protein localization to endoplasmic reticulum (GO:0070972)3.11029684
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10737863
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.09534114
70positive regulation of Cdc42 GTPase activity (GO:0043089)3.08857727
71T cell migration (GO:0072678)3.08817406
72ethanol oxidation (GO:0006069)3.08017347
73negative regulation of phagocytosis (GO:0050765)3.06905019
74regulation of T cell tolerance induction (GO:0002664)3.06576563
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06180632
76negative regulation of fibrinolysis (GO:0051918)3.05747518
77regulation of gamma-delta T cell activation (GO:0046643)3.05435161
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03827076
79negative regulation of leukocyte mediated immunity (GO:0002704)3.03528978
80neutrophil activation involved in immune response (GO:0002283)3.02578496
81response to peptidoglycan (GO:0032494)3.02455317
82phospholipid efflux (GO:0033700)2.99033456
83complement activation, alternative pathway (GO:0006957)2.98585461
84antigen processing and presentation via MHC class Ib (GO:0002475)2.95496707
85germinal center formation (GO:0002467)2.93359918
86regulation of antigen processing and presentation (GO:0002577)2.92628159
87lysine catabolic process (GO:0006554)2.92163938
88lysine metabolic process (GO:0006553)2.92163938
89serine family amino acid biosynthetic process (GO:0009070)2.91979620
90nitrogen cycle metabolic process (GO:0071941)2.88276320
91viral life cycle (GO:0019058)2.88260339
92negative regulation of erythrocyte differentiation (GO:0045647)2.87938968
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87834873
94positive regulation of antigen processing and presentation (GO:0002579)2.87483387
95positive regulation of B cell differentiation (GO:0045579)2.87214807
96cellular response to interleukin-15 (GO:0071350)2.87187719
97regulation of protein activation cascade (GO:2000257)2.86187219
98regulation of triglyceride catabolic process (GO:0010896)2.86136272
99high-density lipoprotein particle remodeling (GO:0034375)2.85587698
100macrophage activation involved in immune response (GO:0002281)2.84091888
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83529588
102GDP-mannose metabolic process (GO:0019673)2.83348060
103serine family amino acid catabolic process (GO:0009071)2.82694443
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82105299
105short-chain fatty acid metabolic process (GO:0046459)2.81954973
106modulation by virus of host process (GO:0019054)2.81189792
107positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81091208
108regulation of natural killer cell mediated immunity (GO:0002715)2.80709685
109regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80709685
110cellular protein complex disassembly (GO:0043624)2.80632961
111regulation of fibrinolysis (GO:0051917)2.80273076
112regulation of cholesterol biosynthetic process (GO:0045540)2.79816241
113urate metabolic process (GO:0046415)2.79237631
114regulation of cholesterol metabolic process (GO:0090181)2.79079635
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.76189604
116DNA deamination (GO:0045006)2.76087832
117regulation of alpha-beta T cell proliferation (GO:0046640)2.75657534
118regulation of cholesterol homeostasis (GO:2000188)2.75168605
119regulation of mast cell degranulation (GO:0043304)2.74558797
120CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74492598
121maturation of SSU-rRNA (GO:0030490)2.74327479
122detection of external biotic stimulus (GO:0098581)2.73774004
123serine family amino acid metabolic process (GO:0009069)2.72558616
124antigen receptor-mediated signaling pathway (GO:0050851)2.72364438
125negative regulation of T cell mediated immunity (GO:0002710)2.72069064
126positive regulation of histone deacetylation (GO:0031065)2.71907394
127* regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71865788
128regulation of T cell mediated cytotoxicity (GO:0001914)2.71795562
129regulation of complement activation (GO:0030449)2.71446380
130respiratory burst (GO:0045730)2.70669136
131regulation of tolerance induction (GO:0002643)2.70641865
132peptidyl-glutamic acid carboxylation (GO:0017187)2.69100828
133protein carboxylation (GO:0018214)2.69100828
134defense response to protozoan (GO:0042832)2.68636567
135negative regulation of sterol transport (GO:0032372)2.67782143
136negative regulation of cholesterol transport (GO:0032375)2.67782143
137ethanol metabolic process (GO:0006067)2.66672960
138flavonoid metabolic process (GO:0009812)2.66615560
139bile acid and bile salt transport (GO:0015721)2.66459987
140aromatic amino acid family metabolic process (GO:0009072)2.66318933
141B cell mediated immunity (GO:0019724)2.66286976
142B cell homeostasis (GO:0001782)2.65457226
143amino-acid betaine metabolic process (GO:0006577)2.64863091
144translational initiation (GO:0006413)2.64121385
145negative regulation of glycoprotein biosynthetic process (GO:0010561)2.64106008
146interferon-gamma secretion (GO:0072643)2.63852377
147homocysteine metabolic process (GO:0050667)2.62025897
148primary alcohol catabolic process (GO:0034310)2.61448322
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61273396
150regulation of leukocyte degranulation (GO:0043300)2.58608710
151regulation of interleukin-2 biosynthetic process (GO:0045076)2.58576487
152bile acid metabolic process (GO:0008206)2.58285255
153fatty acid beta-oxidation (GO:0006635)2.56730318
154positive thymic T cell selection (GO:0045059)2.56313379
155response to protozoan (GO:0001562)2.55235849
156mucosal-associated lymphoid tissue development (GO:0048537)2.54749131
157Peyers patch development (GO:0048541)2.54749131
158lymphocyte homeostasis (GO:0002260)2.54669983
159T cell receptor signaling pathway (GO:0050852)2.52817222
160drug transmembrane transport (GO:0006855)2.52715077
161cellular response to interleukin-4 (GO:0071353)2.52211778
162* interferon-gamma-mediated signaling pathway (GO:0060333)2.50954952
1633-UTR-mediated mRNA stabilization (GO:0070935)2.50794755
164reverse cholesterol transport (GO:0043691)2.50119559
165modulation by symbiont of host cellular process (GO:0044068)2.49918049
166L-serine metabolic process (GO:0006563)2.49371748
167positive regulation of granulocyte differentiation (GO:0030854)2.49234807
168negative regulation of interleukin-12 production (GO:0032695)2.49197497
169T cell costimulation (GO:0031295)2.48757407
170lymphocyte migration (GO:0072676)2.47954870
171nucleoside salvage (GO:0043174)2.47843426
172regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.46913068
173alpha-amino acid catabolic process (GO:1901606)2.46835300
174lymphocyte costimulation (GO:0031294)2.44666430
175drug transport (GO:0015893)2.44215248
176regulation of cholesterol esterification (GO:0010872)2.43830424
177protein complex disassembly (GO:0043241)2.43415546
178phospholipid scrambling (GO:0017121)2.43143793
179pentose-phosphate shunt (GO:0006098)2.42631150
180imidazole-containing compound metabolic process (GO:0052803)2.42600227
181complement activation, classical pathway (GO:0006958)2.42397256
182regulation of defense response to virus by virus (GO:0050690)2.41915718
183positive regulation of triglyceride metabolic process (GO:0090208)2.41859999
184nucleotide salvage (GO:0043173)2.39247787
185protein-lipid complex remodeling (GO:0034368)2.39060458
186macromolecular complex remodeling (GO:0034367)2.39060458
187plasma lipoprotein particle remodeling (GO:0034369)2.39060458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.98023321
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.34804695
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.30384245
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26735385
5E2F7_22180533_ChIP-Seq_HELA_Human3.12489823
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87229390
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.72671833
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72317149
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.53094452
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32090095
11MYC_22102868_ChIP-Seq_BL_Human2.28674178
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.28618266
13VDR_21846776_ChIP-Seq_THP-1_Human2.23119781
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18934271
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11072085
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09427698
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05515113
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99452602
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96982751
20KDM2B_26808549_Chip-Seq_DND41_Human1.96736408
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94149673
22SCL_19346495_ChIP-Seq_HPC-7_Human1.92081929
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89510744
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88641519
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88626752
26RACK7_27058665_Chip-Seq_MCF-7_Human1.86690055
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.78499637
28P68_20966046_ChIP-Seq_HELA_Human1.76671961
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76519004
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76357515
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75093838
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73783156
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68237337
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67296616
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65149980
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62580801
37MAF_26560356_Chip-Seq_TH1_Human1.61999565
38BCOR_27268052_Chip-Seq_Bcells_Human1.58804689
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.58215109
40UTX_26944678_Chip-Seq_JUKART_Human1.55802599
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.54316762
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52918039
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.51277885
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50578076
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47125842
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46365038
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45190859
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44175540
49VDR_24763502_ChIP-Seq_THP-1_Human1.42851384
50MYB_26560356_Chip-Seq_TH1_Human1.41378943
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40884644
52GATA1_22025678_ChIP-Seq_K562_Human1.39029127
53* SPI1_23547873_ChIP-Seq_NB4_Human1.38996433
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.37740424
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36465471
56MAF_26560356_Chip-Seq_TH2_Human1.34955959
57NCOR1_26117541_ChIP-Seq_K562_Human1.34683995
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34645750
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33966956
60* RUNX1_22412390_ChIP-Seq_EML_Mouse1.33091327
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33009719
62MYB_26560356_Chip-Seq_TH2_Human1.32883603
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.31794719
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31057991
65TCF7_22412390_ChIP-Seq_EML_Mouse1.30830265
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30755590
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30522615
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29983128
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29870922
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27565746
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27431393
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27376878
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26807280
74LXR_22292898_ChIP-Seq_THP-1_Human1.26316787
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26223199
76SMC4_20622854_ChIP-Seq_HELA_Human1.25659511
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24767612
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24529039
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.24084945
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.22827612
81SPI1_23127762_ChIP-Seq_K562_Human1.22209960
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21035138
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.19738149
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.19706729
85E2F1_20622854_ChIP-Seq_HELA_Human1.17769129
86PHF8_20622854_ChIP-Seq_HELA_Human1.16996045
87XRN2_22483619_ChIP-Seq_HELA_Human1.15797034
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14512765
89CIITA_25753668_ChIP-Seq_RAJI_Human1.12851395
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12618345
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11824138
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.11660331
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10684225
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10548360
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10534761
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10505795
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09717936
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09349071
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.09161151
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09035341
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.08577660
102* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08574997
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08390929
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07902580
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07866072
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07145597
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06916228
108CTCF_21964334_Chip-Seq_Bcells_Human1.06672803
109SA1_27219007_Chip-Seq_Bcells_Human1.06316083
110CREB1_26743006_Chip-Seq_LNCaP_Human1.06313440
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.06296612
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06263004
113EST1_17652178_ChIP-ChIP_JURKAT_Human1.05772039
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04935416
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04811676
116FOXP3_21729870_ChIP-Seq_TREG_Human1.04435533
117VDR_23849224_ChIP-Seq_CD4+_Human1.04274963
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04238933
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03945103
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03925298
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.03823736
122BCL6_27268052_Chip-Seq_Bcells_Human1.03410270
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03217373
124MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03173730
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02922708
126MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02794197
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01531001
128GATA1_19941827_ChIP-Seq_MEL_Mouse1.01120056
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00980634
130RUNX_20019798_ChIP-Seq_JUKART_Human1.00607345
131DCP1A_22483619_ChIP-Seq_HELA_Human1.00563421
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99867913
133GABP_17652178_ChIP-ChIP_JURKAT_Human0.99299209
134TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98150082
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96591688
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96393778
137CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96035975
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95840409
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95449281
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95013880
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.92856300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.07877277
2MP0002139_abnormal_hepatobiliary_system4.04186712
3MP0005365_abnormal_bile_salt3.26485018
4MP0005085_abnormal_gallbladder_physiolo3.13434403
5MP0003806_abnormal_nucleotide_metabolis2.81220552
6MP0008875_abnormal_xenobiotic_pharmacok2.68284576
7MP0003191_abnormal_cellular_cholesterol2.56781441
8MP0001835_abnormal_antigen_presentation2.38892774
9MP0000685_abnormal_immune_system2.37268093
10MP0009840_abnormal_foam_cell2.27214206
11MP0003763_abnormal_thymus_physiology2.09631001
12MP0003252_abnormal_bile_duct2.09042280
13MP0002166_altered_tumor_susceptibility2.04974768
14MP0002396_abnormal_hematopoietic_system2.00572387
15MP0003172_abnormal_lysosome_physiology1.94003665
16MP0001873_stomach_inflammation1.90832645
17MP0001666_abnormal_nutrient_absorption1.87594760
18MP0001800_abnormal_humoral_immune1.86940907
19MP0008260_abnormal_autophagy1.83446013
20MP0003436_decreased_susceptibility_to1.83037224
21MP0010329_abnormal_lipoprotein_level1.77099543
22MP0005671_abnormal_response_to1.72484456
23MP0009785_altered_susceptibility_to1.72221116
24MP0005387_immune_system_phenotype1.69088016
25MP0001790_abnormal_immune_system1.69088016
26MP0005083_abnormal_biliary_tract1.68647936
27MP0003300_gastrointestinal_ulcer1.67566095
28* MP0005025_abnormal_response_to1.64436067
29MP0000609_abnormal_liver_physiology1.60043548
30MP0005464_abnormal_platelet_physiology1.56901156
31MP0004381_abnormal_hair_follicle1.55992949
32MP0002138_abnormal_hepatobiliary_system1.54749843
33MP0003724_increased_susceptibility_to1.53732478
34MP0002452_abnormal_antigen_presenting1.52513987
35MP0010155_abnormal_intestine_physiology1.47649937
36MP0005075_abnormal_melanosome_morpholog1.47413992
37* MP0002723_abnormal_immune_serum1.47118273
38MP0002420_abnormal_adaptive_immunity1.42998092
39MP0001819_abnormal_immune_cell1.40770501
40MP0009333_abnormal_splenocyte_physiolog1.39845057
41MP0004947_skin_inflammation1.39782644
42MP0002398_abnormal_bone_marrow1.39708147
43MP0005319_abnormal_enzyme/_coenzyme1.39408732
44MP0005000_abnormal_immune_tolerance1.39028975
45MP0005332_abnormal_amino_acid1.38109795
46MP0002006_tumorigenesis1.37849961
47MP0000689_abnormal_spleen_morphology1.36418190
48MP0001853_heart_inflammation1.36258053
49MP0009643_abnormal_urine_homeostasis1.35102111
50* MP0008469_abnormal_protein_level1.34444604
51MP0001764_abnormal_homeostasis1.31722465
52MP0000716_abnormal_immune_system1.29619901
53MP0002419_abnormal_innate_immunity1.29209627
54MP0003183_abnormal_peptide_metabolism1.28461954
55MP0004264_abnormal_extraembryonic_tissu1.27188439
56MP0002722_abnormal_immune_system1.26242673
57MP0001845_abnormal_inflammatory_respons1.25583896
58MP0005076_abnormal_cell_differentiation1.25335380
59MP0003186_abnormal_redox_activity1.23788693
60MP0003866_abnormal_defecation1.21944368
61MP0001849_ear_inflammation1.20990973
62MP0002405_respiratory_system_inflammati1.19668111
63MP0002429_abnormal_blood_cell1.19486214
64MP0005397_hematopoietic_system_phenotyp1.18808470
65MP0001545_abnormal_hematopoietic_system1.18808470
66MP0003453_abnormal_keratinocyte_physiol1.18791564
67MP0005310_abnormal_salivary_gland1.16115985
68MP0004019_abnormal_vitamin_homeostasis1.15187664
69MP0003656_abnormal_erythrocyte_physiolo1.13027633
70MP0005584_abnormal_enzyme/coenzyme_acti1.12043972
71MP0006054_spinal_hemorrhage1.11430467
72MP0000465_gastrointestinal_hemorrhage1.10866317
73MP0000598_abnormal_liver_morphology1.07958756
74MP0000678_abnormal_parathyroid_gland1.07704172
75MP0004185_abnormal_adipocyte_glucose1.05720090
76MP0002998_abnormal_bone_remodeling1.03710260
77MP0002148_abnormal_hypersensitivity_rea1.03200003
78MP0000490_abnormal_crypts_of1.02854580
79MP0003315_abnormal_perineum_morphology1.02423429
80MP0002118_abnormal_lipid_homeostasis1.02003788
81MP0002132_abnormal_respiratory_system1.01089646
82MP0003693_abnormal_embryo_hatching1.00999174
83MP0005670_abnormal_white_adipose1.00430127
84MP0009764_decreased_sensitivity_to1.00268007
85MP0009763_increased_sensitivity_to0.99823100
86MP0001851_eye_inflammation0.98827566
87MP0001348_abnormal_lacrimal_gland0.96640303
88MP0010352_gastrointestinal_tract_polyps0.96491692
89MP0004808_abnormal_hematopoietic_stem0.96251294
90MP0009379_abnormal_foot_pigmentation0.94117138
91MP0003705_abnormal_hypodermis_morpholog0.93151281
92MP0000703_abnormal_thymus_morphology0.92309174
93MP0004510_myositis0.92094213
94MP0002136_abnormal_kidney_physiology0.90899257
95MP0005451_abnormal_body_composition0.90242998
96MP0000858_altered_metastatic_potential0.89484051
97MP0005636_abnormal_mineral_homeostasis0.89025653
98MP0002796_impaired_skin_barrier0.89017602
99MP0005390_skeleton_phenotype0.88299424
100MP0003303_peritoneal_inflammation0.88280073
101MP0006082_CNS_inflammation0.85464629
102MP0003195_calcinosis0.83120337
103MP0003868_abnormal_feces_composition0.80040923
104MP0009931_abnormal_skin_appearance0.80038279
105MP0002254_reproductive_system_inflammat0.78400827
106MP0003011_delayed_dark_adaptation0.78063733
107MP0002933_joint_inflammation0.78057970
108MP0005023_abnormal_wound_healing0.77467163
109MP0001663_abnormal_digestive_system0.77148876
110MP0002019_abnormal_tumor_incidence0.76660183
111MP0001533_abnormal_skeleton_physiology0.76185029
112MP0006036_abnormal_mitochondrial_physio0.75900247
113MP0005501_abnormal_skin_physiology0.75774721
114MP0003279_aneurysm0.74838708
115MP0000477_abnormal_intestine_morphology0.74295928
116MP0001986_abnormal_taste_sensitivity0.74230790
117MP0005058_abnormal_lysosome_morphology0.73379473
118MP0005666_abnormal_adipose_tissue0.72489550
119MP0002928_abnormal_bile_duct0.71724543
120MP0005166_decreased_susceptibility_to0.71692880
121MP0004147_increased_porphyrin_level0.71274199
122MP0009278_abnormal_bone_marrow0.70721251
123* MP0009642_abnormal_blood_homeostasis0.70225646
124MP0004858_abnormal_nervous_system0.69166344
125MP0003566_abnormal_cell_adhesion0.68778450
126MP0000249_abnormal_blood_vessel0.68121874
127MP0005381_digestive/alimentary_phenotyp0.67045794
128MP0003795_abnormal_bone_structure0.64045629
129MP0001216_abnormal_epidermal_layer0.61167358
130MP0003448_altered_tumor_morphology0.60148489
131MP0005375_adipose_tissue_phenotype0.59455069

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.39048682
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.09214991
3Intrahepatic cholestasis (HP:0001406)4.09105969
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.79422077
5Increased IgE level (HP:0003212)3.72705242
6Abnormality of macrophages (HP:0004311)3.64227355
7Deep venous thrombosis (HP:0002625)3.59374683
8Meningitis (HP:0001287)3.48298187
9Myositis (HP:0100614)3.45853795
10Obstructive lung disease (HP:0006536)3.37895155
11Chronic obstructive pulmonary disease (HP:0006510)3.37895155
12Mediastinal lymphadenopathy (HP:0100721)3.31658382
13Xanthomatosis (HP:0000991)3.30981109
14Cellulitis (HP:0100658)3.26644442
15Thrombocytosis (HP:0001894)3.25739815
16Prolonged partial thromboplastin time (HP:0003645)3.20329712
17Recurrent cutaneous fungal infections (HP:0011370)3.15880666
18Chronic mucocutaneous candidiasis (HP:0002728)3.15880666
19Gastrointestinal infarctions (HP:0005244)3.14615411
20Polycythemia (HP:0001901)3.11108378
21Hypobetalipoproteinemia (HP:0003563)3.09388950
22Abnormality of cells of the erythroid lineage (HP:0012130)3.00057209
23Hyperammonemia (HP:0001987)2.90661505
24Elevated erythrocyte sedimentation rate (HP:0003565)2.88622184
25Chronic otitis media (HP:0000389)2.87151044
26Vasculitis (HP:0002633)2.85568797
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84597446
28IgM deficiency (HP:0002850)2.82365612
29Abnormal number of erythroid precursors (HP:0012131)2.80356460
30Complement deficiency (HP:0004431)2.74854297
31Joint hemorrhage (HP:0005261)2.74568350
32Pustule (HP:0200039)2.70482046
33Hyperlipoproteinemia (HP:0010980)2.68403731
34Hemorrhage of the eye (HP:0011885)2.67638172
35Abnormality of the nasal mucosa (HP:0000433)2.66526132
36Emphysema (HP:0002097)2.65383459
37Recurrent bronchitis (HP:0002837)2.65350449
38Encephalitis (HP:0002383)2.64969842
39Orchitis (HP:0100796)2.63621545
40Abnormality of fatty-acid metabolism (HP:0004359)2.62345812
41Hyperglycinuria (HP:0003108)2.60227576
42Reticulocytopenia (HP:0001896)2.55720999
43Hypertensive crisis (HP:0100735)2.55393162
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55115843
45Ketosis (HP:0001946)2.52207812
46Nasal polyposis (HP:0100582)2.52192350
47Abnormality of the common coagulation pathway (HP:0010990)2.51239620
48Hypochromic anemia (HP:0001931)2.49766141
49Hyperbilirubinemia (HP:0002904)2.49359273
50Recurrent viral infections (HP:0004429)2.49248572
51Inflammation of the large intestine (HP:0002037)2.45922517
52Fat malabsorption (HP:0002630)2.45640028
53Gastrointestinal inflammation (HP:0004386)2.44428749
54Broad face (HP:0000283)2.44028645
55Epistaxis (HP:0000421)2.43664317
56Gingivitis (HP:0000230)2.43631339
57Dicarboxylic aciduria (HP:0003215)2.43485830
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43485830
59Gingival bleeding (HP:0000225)2.42674203
60Malnutrition (HP:0004395)2.42617800
61Seborrheic dermatitis (HP:0001051)2.40429715
62Spontaneous hematomas (HP:0007420)2.40312720
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.39942512
64Abnormality of pyrimidine metabolism (HP:0004353)2.39527696
65Urticaria (HP:0001025)2.38556462
66J-shaped sella turcica (HP:0002680)2.37745231
67Stomatitis (HP:0010280)2.34857101
68Abnormality of glycine metabolism (HP:0010895)2.34577066
69Abnormality of serine family amino acid metabolism (HP:0010894)2.34577066
70Polygenic inheritance (HP:0010982)2.34222340
71Hyperglycinemia (HP:0002154)2.34005707
72Granulocytopenia (HP:0001913)2.33371792
73Abnormality of T cells (HP:0002843)2.32977089
74Recurrent fungal infections (HP:0002841)2.31625011
75Abnormality of T cell physiology (HP:0011840)2.31567156
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.31530683
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31113621
78Colitis (HP:0002583)2.30802949
79Delayed CNS myelination (HP:0002188)2.30615516
80Abnormality of methionine metabolism (HP:0010901)2.30178712
81Increased cerebral lipofuscin (HP:0011813)2.30107709
82Dysostosis multiplex (HP:0000943)2.29965365
83Increased IgM level (HP:0003496)2.29366751
84Petechiae (HP:0000967)2.28901263
85Acanthocytosis (HP:0001927)2.27598819
86Chest pain (HP:0100749)2.27042094
87Hypoplasia of the thymus (HP:0000778)2.26603374
88Hypoglycemic coma (HP:0001325)2.25966952
89Abnormality of the fingertips (HP:0001211)2.24395906
90Prolonged bleeding time (HP:0003010)2.23831301
91Increased serum ferritin (HP:0003281)2.20515170
92Macrocytic anemia (HP:0001972)2.20492596
93Abnormal platelet function (HP:0011869)2.19360250
94Impaired platelet aggregation (HP:0003540)2.19360250
95Vacuolated lymphocytes (HP:0001922)2.18882197
96Aplastic anemia (HP:0001915)2.16958058
97Abnormality of complement system (HP:0005339)2.16927690
98Abnormality of the intrinsic pathway (HP:0010989)2.15683406
99T lymphocytopenia (HP:0005403)2.14922587
100Agammaglobulinemia (HP:0004432)2.14909204
101Optic neuritis (HP:0100653)2.14792933
102Retrobulbar optic neuritis (HP:0100654)2.14792933
103Hypolipoproteinemia (HP:0010981)2.13239952
104Recurrent bacterial skin infections (HP:0005406)2.13018208
105Pulmonary infiltrates (HP:0002113)2.12300833
106Restrictive lung disease (HP:0002091)2.11568067
107Osteomyelitis (HP:0002754)2.10645841
108Myocardial infarction (HP:0001658)2.10451812
109Purpura (HP:0000979)2.09651325
110Hypergammaglobulinemia (HP:0010702)2.09631007
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08659053
112Abnormality of iron homeostasis (HP:0011031)2.08410092
113Viral hepatitis (HP:0006562)2.07792066
114Microcytic anemia (HP:0001935)2.07598069
115Steatorrhea (HP:0002570)2.07022937
116Thin bony cortex (HP:0002753)2.06745653
117Hypercholesterolemia (HP:0003124)2.05726449
118Abnormality of T cell number (HP:0011839)2.05677290
119Gastrointestinal dysmotility (HP:0002579)2.05223894
120Eczematoid dermatitis (HP:0000976)2.04602665
121Hypertriglyceridemia (HP:0002155)2.03849705
122Premature loss of primary teeth (HP:0006323)2.03452246
123Panhypogammaglobulinemia (HP:0003139)2.02634091
124Skin ulcer (HP:0200042)2.01864060
125Generalized aminoaciduria (HP:0002909)2.01736329
126Recurrent gram-negative bacterial infections (HP:0005420)2.00925526
127Autoimmune thrombocytopenia (HP:0001973)2.00354688
128Recurrent skin infections (HP:0001581)1.99824314
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98882500
130Late onset (HP:0003584)1.98623907
131Abnormality of transition element cation homeostasis (HP:0011030)1.96780495
132Gastrointestinal stroma tumor (HP:0100723)1.95806382
133Pallor (HP:0000980)1.95402645
134Periodontitis (HP:0000704)1.95183886
135Lymphopenia (HP:0001888)1.95132817
136Skin rash (HP:0000988)1.93506274
137Easy fatigability (HP:0003388)1.93048189
138Basal cell carcinoma (HP:0002671)1.92245495
139Hepatosplenomegaly (HP:0001433)1.91722340
140Recurrent abscess formation (HP:0002722)1.91703045
141Abnormality of small intestinal villus morphology (HP:0011472)1.91559626
142Villous atrophy (HP:0011473)1.91559626
143Menorrhagia (HP:0000132)1.90995896
144Recurrent lower respiratory tract infections (HP:0002783)1.90805379
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.90463264
146Ureteral stenosis (HP:0000071)1.90333756
147Abnormality of nucleobase metabolism (HP:0010932)1.90174098
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89517946
149Abnormality of polysaccharide metabolism (HP:0011012)1.89517946
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89517946
151Reduced antithrombin III activity (HP:0001976)1.88517613
152Elevated hepatic transaminases (HP:0002910)1.87381230
153Recurrent sinusitis (HP:0011108)1.86696074
154Papilloma (HP:0012740)1.86330863
155Verrucae (HP:0200043)1.86330863
156Joint stiffness (HP:0001387)1.86209951
157Autoimmune hemolytic anemia (HP:0001890)1.85479166
158Esophageal varix (HP:0002040)1.84913196
159Systemic lupus erythematosus (HP:0002725)1.84364705
160Septate vagina (HP:0001153)1.83995410
161Sepsis (HP:0100806)1.83777693
162Hemoptysis (HP:0002105)1.83622800
163Interstitial pulmonary disease (HP:0006530)1.82877341
164Obstructive sleep apnea (HP:0002870)1.81025547
165Urinary glycosaminoglycan excretion (HP:0003541)1.81019770
166Mucopolysacchariduria (HP:0008155)1.81019770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.12800362
2ERN13.08977165
3SMG12.98267501
4BCKDK2.82411672
5PRPF4B2.80156889
6* TBK12.60087312
7RIPK42.50274912
8TYK22.32277847
9NME22.22748805
10FGFR42.21877137
11GRK62.18111074
12KIT2.06616480
13MAP3K102.04281629
14KDR2.04023673
15FLT32.00074419
16EEF2K1.95006657
17TRIB31.90626939
18ZAP701.90165382
19PKN21.87704891
20SIK11.80512785
21MAP2K31.80259081
22BTK1.76130367
23TGFBR21.69849402
24JAK31.68352617
25MAP3K131.67945694
26LRRK21.67755323
27TGFBR11.66906451
28TEC1.61933508
29TXK1.54749144
30STK101.49524350
31BLK1.48971902
32FES1.40838621
33STK161.39751483
34PIM21.38674759
35CSF1R1.38477734
36SIK21.35409622
37* IKBKE1.33590024
38SIK31.30422146
39TAOK31.29880538
40IRAK31.29349966
41MAPK111.27885727
42TLK11.27092498
43RPS6KA41.25656698
44MAP3K111.17973754
45CDC42BPA1.15670923
46EPHA21.13803033
47ITK1.13639899
48MST41.10238903
49TIE11.10003309
50MAP3K141.09867874
51MAP3K31.08322373
52SYK1.04784230
53IRAK41.03350249
54ICK1.03303376
55NLK1.01927155
56CSK0.99364691
57TESK20.98581984
58JAK10.97234912
59PIM10.96573684
60CDK120.95469298
61HIPK20.95270694
62RPS6KB20.93697378
63CDK40.89906326
64LCK0.85812850
65TAOK10.84649904
66MARK20.83747048
67MAPKAPK30.83153398
68TAOK20.82426126
69VRK20.81956938
70LYN0.80658397
71* IKBKB0.80363548
72MAP3K10.79988693
73BMX0.78936258
74PTK60.77293796
75NEK90.75492493
76EIF2AK10.73434757
77MAP2K20.71878576
78MAP3K70.70522936
79JAK20.69135831
80HCK0.66340443
81RPS6KA20.65889230
82MAP3K80.65525897
83TESK10.65022417
84PIK3CG0.63349540
85MAPK70.61973796
86TTN0.61522906
87MYLK0.60684777
88CDK70.59962597
89FGFR30.59037482
90PDPK10.58184220
91MARK30.57365366
92PDK10.56642355
93PAK40.54995186
94NEK20.54741743
95CAMKK10.54496972
96MAPKAPK20.53147644
97STK40.52616359
98CHUK0.52345087
99MST1R0.52168903
100WEE10.51943966
101MAPK40.51751706
102RIPK10.51689870
103IRAK20.51433229
104FGR0.51372343
105MAP3K60.49217349
106TNK20.49082344
107ARAF0.48864660
108PRKG20.48726568
109ACVR1B0.48003251
110MAPK120.46854209
111CDK60.46202666
112RPS6KA50.45514713
113RPS6KA60.44292033
114PRKAA20.43150005
115SCYL20.40880004
116MELK0.40768509
117ILK0.40308213
118MATK0.40176674
119MAPK150.39141782
120AURKB0.38612774
121PRKD20.37826709
122CLK10.37552096
123PASK0.37045131
124RPS6KL10.35409268
125RPS6KC10.35409268
126EIF2AK30.35274939
127DYRK1B0.34776550
128MAP2K60.32816896
129EPHB10.32315485
130PRKCQ0.32281565

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.01320968
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71114802
3Allograft rejection_Homo sapiens_hsa053302.64462234
4Autoimmune thyroid disease_Homo sapiens_hsa053202.55443981
5Ribosome_Homo sapiens_hsa030102.52654434
6Graft-versus-host disease_Homo sapiens_hsa053322.50370659
7Fatty acid degradation_Homo sapiens_hsa000712.16724964
8Caffeine metabolism_Homo sapiens_hsa002322.05273332
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01358464
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98825009
11Sulfur relay system_Homo sapiens_hsa041221.98521816
12Primary immunodeficiency_Homo sapiens_hsa053401.98482173
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98399036
14Tryptophan metabolism_Homo sapiens_hsa003801.96052910
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87949756
16Complement and coagulation cascades_Homo sapiens_hsa046101.82865768
17DNA replication_Homo sapiens_hsa030301.76087382
18Selenocompound metabolism_Homo sapiens_hsa004501.75990760
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.73368883
20Folate biosynthesis_Homo sapiens_hsa007901.72675398
21Asthma_Homo sapiens_hsa053101.72376972
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71827110
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71797389
24Nitrogen metabolism_Homo sapiens_hsa009101.70424716
25Type I diabetes mellitus_Homo sapiens_hsa049401.69267188
26Staphylococcus aureus infection_Homo sapiens_hsa051501.64229670
27Arginine biosynthesis_Homo sapiens_hsa002201.62212206
28Viral myocarditis_Homo sapiens_hsa054161.60559628
29Propanoate metabolism_Homo sapiens_hsa006401.58724464
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56232592
31Peroxisome_Homo sapiens_hsa041461.54907889
32One carbon pool by folate_Homo sapiens_hsa006701.47634495
33Tuberculosis_Homo sapiens_hsa051521.44708543
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42783420
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42164118
36Chemical carcinogenesis_Homo sapiens_hsa052041.41781108
37Notch signaling pathway_Homo sapiens_hsa043301.40286035
38* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37696634
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37322878
40Pentose phosphate pathway_Homo sapiens_hsa000301.34430803
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33177362
42Histidine metabolism_Homo sapiens_hsa003401.32321764
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31973495
44Non-small cell lung cancer_Homo sapiens_hsa052231.30843125
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.30196030
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28790355
47PPAR signaling pathway_Homo sapiens_hsa033201.28564414
48Chronic myeloid leukemia_Homo sapiens_hsa052201.27621513
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.26853020
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26745831
51beta-Alanine metabolism_Homo sapiens_hsa004101.26367067
52ABC transporters_Homo sapiens_hsa020101.24931622
53VEGF signaling pathway_Homo sapiens_hsa043701.20031242
54Fatty acid metabolism_Homo sapiens_hsa012121.18159426
55Pyruvate metabolism_Homo sapiens_hsa006201.17298962
56TNF signaling pathway_Homo sapiens_hsa046681.16887805
57Apoptosis_Homo sapiens_hsa042101.15995227
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.15159777
59Carbon metabolism_Homo sapiens_hsa012001.14822674
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10086231
61Base excision repair_Homo sapiens_hsa034101.09091696
62Pancreatic cancer_Homo sapiens_hsa052121.06344729
63Chemokine signaling pathway_Homo sapiens_hsa040621.05636251
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.05488188
65* Hepatitis B_Homo sapiens_hsa051611.04877092
66Sulfur metabolism_Homo sapiens_hsa009201.04700888
67Antigen processing and presentation_Homo sapiens_hsa046121.04007276
68* Epstein-Barr virus infection_Homo sapiens_hsa051691.03015863
69Biosynthesis of amino acids_Homo sapiens_hsa012301.02650300
70Retinol metabolism_Homo sapiens_hsa008301.02598950
71HTLV-I infection_Homo sapiens_hsa051661.01548304
72NF-kappa B signaling pathway_Homo sapiens_hsa040641.01468438
73NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00562697
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99742050
75Mismatch repair_Homo sapiens_hsa034300.99707372
76Fat digestion and absorption_Homo sapiens_hsa049750.97350792
77Shigellosis_Homo sapiens_hsa051310.92988124
78Starch and sucrose metabolism_Homo sapiens_hsa005000.92468212
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.92276603
80Lysosome_Homo sapiens_hsa041420.89829626
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88190928
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87232125
83* Viral carcinogenesis_Homo sapiens_hsa052030.86530856
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86114487
85Butanoate metabolism_Homo sapiens_hsa006500.84374185
86Malaria_Homo sapiens_hsa051440.84068674
87Lysine degradation_Homo sapiens_hsa003100.83987996
88Phenylalanine metabolism_Homo sapiens_hsa003600.83216037
89* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81822532
90* Measles_Homo sapiens_hsa051620.80995667
91Hematopoietic cell lineage_Homo sapiens_hsa046400.80948663
92B cell receptor signaling pathway_Homo sapiens_hsa046620.79329081
93Bladder cancer_Homo sapiens_hsa052190.79324541
94Galactose metabolism_Homo sapiens_hsa000520.78641697
95Pyrimidine metabolism_Homo sapiens_hsa002400.77964866
96Tyrosine metabolism_Homo sapiens_hsa003500.76495030
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.75949006
98* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75147389
99Leishmaniasis_Homo sapiens_hsa051400.75127370
100Platelet activation_Homo sapiens_hsa046110.74649580
101Bile secretion_Homo sapiens_hsa049760.74325808
102Vitamin digestion and absorption_Homo sapiens_hsa049770.73406658
103* Herpes simplex infection_Homo sapiens_hsa051680.72488531
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72072128
105Glutathione metabolism_Homo sapiens_hsa004800.71914439
106Other glycan degradation_Homo sapiens_hsa005110.71912783
107Fatty acid elongation_Homo sapiens_hsa000620.71574012
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70727127
109Insulin resistance_Homo sapiens_hsa049310.69951384
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.68732213
111Endocytosis_Homo sapiens_hsa041440.67950500
112Steroid biosynthesis_Homo sapiens_hsa001000.67053803
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65808457
114Glycerolipid metabolism_Homo sapiens_hsa005610.64594281
115Choline metabolism in cancer_Homo sapiens_hsa052310.64038023
116Arginine and proline metabolism_Homo sapiens_hsa003300.59957623
117African trypanosomiasis_Homo sapiens_hsa051430.59566816
118Homologous recombination_Homo sapiens_hsa034400.59088066
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56276372
120Inositol phosphate metabolism_Homo sapiens_hsa005620.55513109
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.55299188
122Legionellosis_Homo sapiens_hsa051340.55281338
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.54692403
124mTOR signaling pathway_Homo sapiens_hsa041500.54339646
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.54042669
126Fructose and mannose metabolism_Homo sapiens_hsa000510.53727456
127* Pertussis_Homo sapiens_hsa051330.52910176
128Small cell lung cancer_Homo sapiens_hsa052220.51465198
129Rheumatoid arthritis_Homo sapiens_hsa053230.51441419
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50484652
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50251859
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49885009
133Endometrial cancer_Homo sapiens_hsa052130.49831286
134Spliceosome_Homo sapiens_hsa030400.49576475
135Phagosome_Homo sapiens_hsa041450.49221302
136Prolactin signaling pathway_Homo sapiens_hsa049170.48896345
137Acute myeloid leukemia_Homo sapiens_hsa052210.48224671
138Thyroid cancer_Homo sapiens_hsa052160.47994067
139Salmonella infection_Homo sapiens_hsa051320.47947054
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46799574
141Renal cell carcinoma_Homo sapiens_hsa052110.46238926
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45669348
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.44765902
144Metabolic pathways_Homo sapiens_hsa011000.44582730
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.43799034
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42731508
147Proteasome_Homo sapiens_hsa030500.42140216
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41992020
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41642719
150Osteoclast differentiation_Homo sapiens_hsa043800.41412029
151GnRH signaling pathway_Homo sapiens_hsa049120.41132130
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40760257
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40289362
154Systemic lupus erythematosus_Homo sapiens_hsa053220.40232768
155Colorectal cancer_Homo sapiens_hsa052100.38898769
156Insulin signaling pathway_Homo sapiens_hsa049100.38578901
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37764982
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.34397532
159* Influenza A_Homo sapiens_hsa051640.34092516
160T cell receptor signaling pathway_Homo sapiens_hsa046600.33461317
161* Hepatitis C_Homo sapiens_hsa051600.33334065
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.33143651
163Nucleotide excision repair_Homo sapiens_hsa034200.33114899
164Non-homologous end-joining_Homo sapiens_hsa034500.32696107
165Toxoplasmosis_Homo sapiens_hsa051450.32417319

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