IRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16028834
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.16028834
3antigen processing and presentation of endogenous antigen (GO:0019883)5.15642620
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93150496
5positive regulation of gamma-delta T cell activation (GO:0046645)4.60327816
6detection of bacterium (GO:0016045)4.28017848
7detection of external biotic stimulus (GO:0098581)3.93947453
8negative regulation of lymphocyte mediated immunity (GO:0002707)3.84670179
9regulation of B cell receptor signaling pathway (GO:0050855)3.77536643
10negative regulation of T cell mediated immunity (GO:0002710)3.71102964
11* response to type I interferon (GO:0034340)3.67638246
12positive regulation of interferon-alpha production (GO:0032727)3.67602434
13* cellular response to type I interferon (GO:0071357)3.63690093
14* type I interferon signaling pathway (GO:0060337)3.63690093
15microglial cell activation (GO:0001774)3.58514966
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57025540
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51921696
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.51921696
19modulation by symbiont of host immune response (GO:0052553)3.51921696
20positive regulation by symbiont of host defense response (GO:0052509)3.51921696
21modulation by symbiont of host defense response (GO:0052031)3.51921696
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51921696
23regulation of interferon-beta biosynthetic process (GO:0045357)3.51414586
24regulation of interferon-alpha production (GO:0032647)3.50469340
25regulation of T cell tolerance induction (GO:0002664)3.48872651
26neutrophil activation involved in immune response (GO:0002283)3.43130439
27detection of biotic stimulus (GO:0009595)3.39798283
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39545373
29immunoglobulin mediated immune response (GO:0016064)3.38020276
30regulation of gamma-delta T cell differentiation (GO:0045586)3.37391814
31negative regulation of leukocyte mediated immunity (GO:0002704)3.36908120
32regulation of tolerance induction (GO:0002643)3.36338291
33regulation of gamma-delta T cell activation (GO:0046643)3.34922547
34positive regulation of B cell differentiation (GO:0045579)3.29345586
35macrophage activation (GO:0042116)3.22793491
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.20489414
37response to host (GO:0075136)3.19233855
38response to host defenses (GO:0052200)3.19233855
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19233855
40positive regulation of antigen processing and presentation (GO:0002579)3.16160590
41regulation of regulatory T cell differentiation (GO:0045589)3.13903622
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13056550
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12362047
44leukocyte aggregation (GO:0070486)3.12252729
45regulation of T cell mediated cytotoxicity (GO:0001914)3.07180264
46positive regulation of type 2 immune response (GO:0002830)3.06875653
47T cell migration (GO:0072678)3.06314870
48respiratory burst (GO:0045730)3.04386632
49positive regulation of tolerance induction (GO:0002645)3.04126208
50cellular extravasation (GO:0045123)3.03702121
51regulation of B cell differentiation (GO:0045577)3.02789658
52B cell receptor signaling pathway (GO:0050853)3.02073162
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01095312
54* interferon-gamma-mediated signaling pathway (GO:0060333)3.00375180
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99356744
56tolerance induction (GO:0002507)2.99218160
57regulation of T-helper 1 cell differentiation (GO:0045625)2.94078340
58positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92696555
59response to peptidoglycan (GO:0032494)2.92312216
60regulation of natural killer cell mediated immunity (GO:0002715)2.92295553
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92295553
62negative regulation of innate immune response (GO:0045824)2.90274951
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89657282
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89625602
65negative regulation of cytokine production involved in immune response (GO:0002719)2.88713367
66macrophage activation involved in immune response (GO:0002281)2.87173842
67neutrophil activation (GO:0042119)2.87117668
68positive regulation of natural killer cell differentiation (GO:0032825)2.86747838
69dendritic cell chemotaxis (GO:0002407)2.86698784
70negative regulation of T-helper cell differentiation (GO:0045623)2.86351550
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86351550
72regulation of T-helper 2 cell differentiation (GO:0045628)2.84881984
73cellular response to exogenous dsRNA (GO:0071360)2.84265144
74negative thymic T cell selection (GO:0045060)2.82736467
75neutrophil mediated immunity (GO:0002446)2.82512117
76defense response to protozoan (GO:0042832)2.82198976
77T cell selection (GO:0045058)2.82141982
78positive thymic T cell selection (GO:0045059)2.82043665
79response to interferon-alpha (GO:0035455)2.81879181
80complement activation, alternative pathway (GO:0006957)2.81198071
81myeloid dendritic cell activation (GO:0001773)2.78865580
82regulation of antigen processing and presentation (GO:0002577)2.78534702
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77336969
84regulation of type 2 immune response (GO:0002828)2.77279514
85granulocyte activation (GO:0036230)2.77095241
86mature B cell differentiation (GO:0002335)2.76647650
87negative T cell selection (GO:0043383)2.74128025
88phospholipid efflux (GO:0033700)2.74118170
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73221208
90negative regulation of cell killing (GO:0031342)2.73221208
91positive regulation of humoral immune response (GO:0002922)2.72096741
92mast cell activation (GO:0045576)2.71870194
93response to muramyl dipeptide (GO:0032495)2.71322061
94myeloid cell activation involved in immune response (GO:0002275)2.70876391
95response to interferon-beta (GO:0035456)2.68148681
96T-helper 1 type immune response (GO:0042088)2.67138002
97tryptophan catabolic process (GO:0006569)2.65524777
98indole-containing compound catabolic process (GO:0042436)2.65524777
99indolalkylamine catabolic process (GO:0046218)2.65524777
100response to interleukin-15 (GO:0070672)2.64962650
101response to protozoan (GO:0001562)2.64808881
102antigen processing and presentation via MHC class Ib (GO:0002475)2.64478997
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63661814
104germinal center formation (GO:0002467)2.62775318
105triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62535351
106positive regulation of interferon-beta production (GO:0032728)2.62521533
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62256296
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61722762
109regulation of alpha-beta T cell proliferation (GO:0046640)2.59852602
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56393996
111myeloid dendritic cell differentiation (GO:0043011)2.56075644
112regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56049866
113mature B cell differentiation involved in immune response (GO:0002313)2.55730411
114positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.52587891
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52289901
116detection of other organism (GO:0098543)2.50466242
117response to host immune response (GO:0052572)2.49659178
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49659178
119cellular response to interferon-beta (GO:0035458)2.49626429
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49277321
121production of molecular mediator involved in inflammatory response (GO:0002532)2.49065472
122cellular response to zinc ion (GO:0071294)2.48183748
123B cell mediated immunity (GO:0019724)2.47913977
124regulation of natural killer cell differentiation (GO:0032823)2.47388843
125interferon-gamma production (GO:0032609)2.47251115
126tryptophan metabolic process (GO:0006568)2.46922689
127aromatic amino acid family catabolic process (GO:0009074)2.45897138
128regulation of response to interferon-gamma (GO:0060330)2.45634022
129lymph node development (GO:0048535)2.45337207
130detection of molecule of bacterial origin (GO:0032490)2.44499390
131cellular response to interleukin-15 (GO:0071350)2.43675127
132positive regulation of cellular amide metabolic process (GO:0034250)2.42104008
133negative regulation of interleukin-12 production (GO:0032695)2.42008134
134positive regulation of immunoglobulin mediated immune response (GO:0002891)2.38494998
135positive regulation of B cell mediated immunity (GO:0002714)2.38494998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.27172194
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.62182064
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.21194801
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.03076958
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.01660592
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.98600992
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.87944276
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.72536637
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.36697404
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22485536
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22440452
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91210228
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.86267376
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.80248846
15SCL_19346495_ChIP-Seq_HPC-7_Human2.79156799
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65721783
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58811003
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49264488
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45190501
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44283635
21RUNX_20019798_ChIP-Seq_JUKART_Human2.41955343
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.29741990
23* LXR_22158963_ChIP-Seq_LIVER_Mouse2.27160061
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26696396
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25460628
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21469080
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14875896
28MYB_26560356_Chip-Seq_TH2_Human2.03452597
29GATA1_22025678_ChIP-Seq_K562_Human2.01929902
30* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97560804
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92572980
32* MAF_26560356_Chip-Seq_TH1_Human1.89946528
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86863206
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84422567
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83033302
36* SPI1_23547873_ChIP-Seq_NB4_Human1.82636902
37MYB_26560356_Chip-Seq_TH1_Human1.80570937
38VDR_24763502_ChIP-Seq_THP-1_Human1.66176588
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.64662975
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.62106643
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58070030
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57609627
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.56426965
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56199333
45VDR_21846776_ChIP-Seq_THP-1_Human1.52650463
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52128387
47* SPI1_23127762_ChIP-Seq_K562_Human1.51922695
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51218060
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50882427
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50340283
51PU_27001747_Chip-Seq_BMDM_Mouse1.49755906
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41432549
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41014922
54UTX_26944678_Chip-Seq_JUKART_Human1.40160038
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39300909
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37762624
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35969927
58MYC_22102868_ChIP-Seq_BL_Human1.35902192
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32889867
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32671552
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32491268
62GATA3_27048872_Chip-Seq_THYMUS_Human1.32315156
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28279055
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.26442794
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.25762152
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25237633
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24132597
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23736678
69VDR_24787735_ChIP-Seq_THP-1_Human1.23537172
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20281310
71GATA3_26560356_Chip-Seq_TH2_Human1.18832555
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16900937
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07957810
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06950483
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06912133
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06721844
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06544978
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05872762
79MAF_26560356_Chip-Seq_TH2_Human1.05327054
80GATA2_19941826_ChIP-Seq_K562_Human1.03081463
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.98401685
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95195418
83* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93763254
84GATA1_19941826_ChIP-Seq_K562_Human0.93352041
85* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92765492
86KDM2B_26808549_Chip-Seq_DND41_Human0.92381484
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92121843
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90693579
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90608192
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90273928
91* SMRT_27268052_Chip-Seq_Bcells_Human0.88839034
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87681870
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86297274
94STAT1_20625510_ChIP-Seq_HELA_Human0.84302777
95BCL6_27268052_Chip-Seq_Bcells_Human0.83678420
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.83248884
97TP63_17297297_ChIP-ChIP_HaCaT_Human0.81212075
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.80155925
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79333014
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77133643
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76571841
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76404400
103EGR1_19032775_ChIP-ChIP_M12_Human0.76373776
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75849414
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75573212
106* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73864202
107BCOR_27268052_Chip-Seq_Bcells_Human0.73177096
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72766480
109* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71777549
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71066671
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70412186
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69902336
113SPI1_20517297_ChIP-Seq_HL60_Human0.69901926
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67767452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.14935255
2MP0009785_altered_susceptibility_to3.07429212
3MP0003436_decreased_susceptibility_to2.98787336
4MP0000685_abnormal_immune_system2.94528232
5* MP0005387_immune_system_phenotype2.90588531
6* MP0001790_abnormal_immune_system2.90588531
7MP0005671_abnormal_response_to2.85202699
8MP0003724_increased_susceptibility_to2.71315437
9* MP0001800_abnormal_humoral_immune2.70587013
10MP0002148_abnormal_hypersensitivity_rea2.64219975
11* MP0005025_abnormal_response_to2.62721651
12MP0005000_abnormal_immune_tolerance2.61907391
13MP0005360_urolithiasis2.53520042
14MP0002419_abnormal_innate_immunity2.52043428
15MP0002139_abnormal_hepatobiliary_system2.50126933
16* MP0002452_abnormal_antigen_presenting2.43916084
17* MP0002723_abnormal_immune_serum2.35355038
18MP0006082_CNS_inflammation2.18015894
19MP0005464_abnormal_platelet_physiology2.17813947
20* MP0001819_abnormal_immune_cell2.16959088
21* MP0002420_abnormal_adaptive_immunity2.16587960
22MP0002166_altered_tumor_susceptibility2.14186425
23MP0003191_abnormal_cellular_cholesterol2.07839751
24MP0003303_peritoneal_inflammation2.06297602
25MP0005365_abnormal_bile_salt1.99244021
26MP0005085_abnormal_gallbladder_physiolo1.95138486
27MP0009840_abnormal_foam_cell1.93396577
28MP0010155_abnormal_intestine_physiology1.87473211
29MP0002138_abnormal_hepatobiliary_system1.85384369
30MP0003300_gastrointestinal_ulcer1.84911108
31MP0003763_abnormal_thymus_physiology1.83311496
32MP0004510_myositis1.81097690
33MP0001853_heart_inflammation1.80117327
34MP0001845_abnormal_inflammatory_respons1.79114701
35MP0002405_respiratory_system_inflammati1.73278735
36* MP0000716_abnormal_immune_system1.73086343
37* MP0002398_abnormal_bone_marrow1.71613088
38MP0008875_abnormal_xenobiotic_pharmacok1.69862112
39MP0008469_abnormal_protein_level1.68556032
40MP0009764_decreased_sensitivity_to1.67419083
41* MP0004947_skin_inflammation1.66266499
42MP0002006_tumorigenesis1.66260168
43MP0005058_abnormal_lysosome_morphology1.63826664
44MP0001873_stomach_inflammation1.58764921
45MP0001533_abnormal_skeleton_physiology1.55026742
46MP0003252_abnormal_bile_duct1.52165643
47MP0000689_abnormal_spleen_morphology1.50200944
48MP0005451_abnormal_body_composition1.44231974
49MP0010329_abnormal_lipoprotein_level1.40010686
50* MP0002429_abnormal_blood_cell1.39721505
51* MP0002722_abnormal_immune_system1.37153936
52MP0009333_abnormal_splenocyte_physiolog1.36356591
53MP0008260_abnormal_autophagy1.34006153
54MP0003828_pulmonary_edema1.31461852
55MP0001545_abnormal_hematopoietic_system1.30257236
56MP0005397_hematopoietic_system_phenotyp1.30257236
57MP0000465_gastrointestinal_hemorrhage1.29763687
58MP0005310_abnormal_salivary_gland1.29338053
59MP0002396_abnormal_hematopoietic_system1.29010908
60MP0000609_abnormal_liver_physiology1.23288448
61MP0004883_abnormal_blood_vessel1.22680015
62MP0009278_abnormal_bone_marrow1.20068467
63MP0009763_increased_sensitivity_to1.17378203
64MP0003183_abnormal_peptide_metabolism1.17057467
65MP0001666_abnormal_nutrient_absorption1.16969018
66MP0003075_altered_response_to1.14846663
67MP0003866_abnormal_defecation1.14816830
68MP0008004_abnormal_stomach_pH1.10819077
69MP0004381_abnormal_hair_follicle1.09516893
70MP0005164_abnormal_response_to1.08865653
71MP0002277_abnormal_respiratory_mucosa1.07365065
72MP0002933_joint_inflammation1.06377178
73MP0004808_abnormal_hematopoietic_stem1.04940732
74MP0005083_abnormal_biliary_tract1.02648004
75MP0000343_altered_response_to1.01918357
76MP0005166_decreased_susceptibility_to1.01420822
77MP0002998_abnormal_bone_remodeling0.99064917
78MP0000858_altered_metastatic_potential0.96910812
79MP0004782_abnormal_surfactant_physiolog0.96260402
80MP0002254_reproductive_system_inflammat0.95444954
81MP0003806_abnormal_nucleotide_metabolis0.95356294
82MP0005319_abnormal_enzyme/_coenzyme0.94052490
83MP0003448_altered_tumor_morphology0.93594126
84MP0005174_abnormal_tail_pigmentation0.92197019
85MP0002132_abnormal_respiratory_system0.92029957
86MP0000703_abnormal_thymus_morphology0.91289711
87MP0003656_abnormal_erythrocyte_physiolo0.89508255
88MP0005584_abnormal_enzyme/coenzyme_acti0.89245474
89MP0003172_abnormal_lysosome_physiology0.87147565
90MP0009643_abnormal_urine_homeostasis0.86969646
91* MP0003045_fibrosis0.86316580
92MP0002118_abnormal_lipid_homeostasis0.85049963
93MP0003690_abnormal_glial_cell0.83725667
94MP0002136_abnormal_kidney_physiology0.80534710
95MP0003186_abnormal_redox_activity0.80452061
96MP0000249_abnormal_blood_vessel0.80445306
97MP0001851_eye_inflammation0.79481164
98MP0002332_abnormal_exercise_endurance0.79424662
99MP0000598_abnormal_liver_morphology0.78417783
100MP0001764_abnormal_homeostasis0.77560666
101MP0005332_abnormal_amino_acid0.77286508
102MP0003195_calcinosis0.77264122
103MP0002928_abnormal_bile_duct0.77173014
104MP0009765_abnormal_xenobiotic_induced0.76891399
105MP0005075_abnormal_melanosome_morpholog0.74588617
106MP0005390_skeleton_phenotype0.72981609
107MP0000490_abnormal_crypts_of0.71762654
108MP0000604_amyloidosis0.68457915
109MP0004019_abnormal_vitamin_homeostasis0.66807348
110MP0001663_abnormal_digestive_system0.65880038
111MP0003566_abnormal_cell_adhesion0.65393762
112MP0009642_abnormal_blood_homeostasis0.65104645
113MP0003091_abnormal_cell_migration0.65008628
114MP0003868_abnormal_feces_composition0.63591423
115MP0008874_decreased_physiological_sensi0.63443064
116MP0000015_abnormal_ear_pigmentation0.63000674
117MP0005167_abnormal_blood-brain_barrier0.62686482
118MP0003795_abnormal_bone_structure0.59433023
119MP0002693_abnormal_pancreas_physiology0.58169387
120MP0003453_abnormal_keratinocyte_physiol0.53372467
121MP0000371_diluted_coat_color0.53149940
122MP0006054_spinal_hemorrhage0.53062384
123MP0000569_abnormal_digit_pigmentation0.50754760

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.89438000
2Eczematoid dermatitis (HP:0000976)4.87654128
3Recurrent bacterial skin infections (HP:0005406)4.76273868
4Recurrent gram-negative bacterial infections (HP:0005420)4.56855984
5Systemic lupus erythematosus (HP:0002725)4.25765184
6Elevated erythrocyte sedimentation rate (HP:0003565)4.00795970
7Myositis (HP:0100614)3.73659818
8Recurrent fungal infections (HP:0002841)3.70341895
9Autoimmune thrombocytopenia (HP:0001973)3.67422303
10Recurrent skin infections (HP:0001581)3.60769221
11Recurrent viral infections (HP:0004429)3.55252695
12Chronic otitis media (HP:0000389)3.45218271
13Complement deficiency (HP:0004431)3.31691315
14Joint hemorrhage (HP:0005261)3.31408389
15Agammaglobulinemia (HP:0004432)3.27946792
16Vasculitis (HP:0002633)3.22417714
17Orchitis (HP:0100796)3.19537704
18Gingival bleeding (HP:0000225)3.19246259
19Vacuolated lymphocytes (HP:0001922)3.16536454
20Chronic mucocutaneous candidiasis (HP:0002728)3.14150401
21Recurrent cutaneous fungal infections (HP:0011370)3.14150401
22Mediastinal lymphadenopathy (HP:0100721)3.14038633
23Abnormality of macrophages (HP:0004311)3.13391993
24Pustule (HP:0200039)3.13178573
25Meningitis (HP:0001287)3.12512337
26Spontaneous hematomas (HP:0007420)3.11861900
27Cellulitis (HP:0100658)3.10560910
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.08755362
29Recurrent bronchitis (HP:0002837)3.04715384
30Glomerulonephritis (HP:0000099)3.03884974
31Prolonged partial thromboplastin time (HP:0003645)3.00816419
32IgM deficiency (HP:0002850)3.00032402
33Colitis (HP:0002583)2.95496570
34Inflammation of the large intestine (HP:0002037)2.87529876
35Optic neuritis (HP:0100653)2.86058276
36Retrobulbar optic neuritis (HP:0100654)2.86058276
37Periodontitis (HP:0000704)2.83193731
38Myocardial infarction (HP:0001658)2.81981410
39Abnormality of complement system (HP:0005339)2.81948474
40Abnormality of T cell number (HP:0011839)2.81781854
41Chest pain (HP:0100749)2.81683037
42Deep venous thrombosis (HP:0002625)2.81486108
43Epistaxis (HP:0000421)2.77570683
44Gingivitis (HP:0000230)2.77510684
45Anorexia (HP:0002039)2.75020052
46Gastrointestinal inflammation (HP:0004386)2.74297029
47T lymphocytopenia (HP:0005403)2.71299717
48Interstitial pulmonary disease (HP:0006530)2.64494511
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64464523
50Nasal polyposis (HP:0100582)2.62092369
51Prolonged bleeding time (HP:0003010)2.62077346
52Obstructive lung disease (HP:0006536)2.61480231
53Chronic obstructive pulmonary disease (HP:0006510)2.61480231
54Hypergammaglobulinemia (HP:0010702)2.59457659
55Abnormality of T cells (HP:0002843)2.58395149
56Xanthomatosis (HP:0000991)2.58203550
57Arterial thrombosis (HP:0004420)2.57970235
58Abnormality of the nasal mucosa (HP:0000433)2.56720452
59Gangrene (HP:0100758)2.56456055
60Petechiae (HP:0000967)2.55444312
61Abnormality of T cell physiology (HP:0011840)2.50357366
62Panhypogammaglobulinemia (HP:0003139)2.50312760
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47520241
64Hypochromic microcytic anemia (HP:0004840)2.47051824
65Stomatitis (HP:0010280)2.46362225
66Pulmonary infiltrates (HP:0002113)2.43419596
67Abnormality of liposaccharide metabolism (HP:0010968)2.41376265
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.41376265
69Abnormality of glycolipid metabolism (HP:0010969)2.41376265
70Gastrointestinal infarctions (HP:0005244)2.41274562
71Episodic fever (HP:0001954)2.41216060
72Abnormality of the pleura (HP:0002103)2.41045380
73Pulmonary embolism (HP:0002204)2.40508953
74Abnormality of the common coagulation pathway (HP:0010990)2.40418805
75Thrombocytosis (HP:0001894)2.37855054
76Chronic diarrhea (HP:0002028)2.37275031
77Thyroiditis (HP:0100646)2.36714141
78Hypochromic anemia (HP:0001931)2.35992809
79IgG deficiency (HP:0004315)2.34507540
80Gastrointestinal stroma tumor (HP:0100723)2.34372875
81Osteomyelitis (HP:0002754)2.32914754
82Purpura (HP:0000979)2.32561647
83Leukocytosis (HP:0001974)2.31863122
84Urticaria (HP:0001025)2.31115953
85Mitral stenosis (HP:0001718)2.30651173
86Encephalitis (HP:0002383)2.29970296
87Microcytic anemia (HP:0001935)2.29712809
88Nephritis (HP:0000123)2.28712664
89Peritonitis (HP:0002586)2.27692431
90Lymphopenia (HP:0001888)2.26636369
91Hemoptysis (HP:0002105)2.25873867
92Abnormality of eosinophils (HP:0001879)2.25731321
93Menorrhagia (HP:0000132)2.25565758
94Hyperlipoproteinemia (HP:0010980)2.24898237
95Sepsis (HP:0100806)2.23038699
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.22484937
97Intrahepatic cholestasis (HP:0001406)2.22094178
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.20185211
99Joint swelling (HP:0001386)2.20045213
100Amyloidosis (HP:0011034)2.18895103
101Recurrent pneumonia (HP:0006532)2.18305822
102Keratoconjunctivitis sicca (HP:0001097)2.16127063
103Increased cerebral lipofuscin (HP:0011813)2.14449633
104Increased IgE level (HP:0003212)2.13443092
105Recurrent sinusitis (HP:0011108)2.11451935
106Dysostosis multiplex (HP:0000943)2.09605170
107Autoimmune hemolytic anemia (HP:0001890)2.08444527
108Abnormality of the peritoneum (HP:0002585)2.06820991
109Eosinophilia (HP:0001880)2.05176174
110Abnormality of B cell number (HP:0010975)2.04436886
111Premature loss of primary teeth (HP:0006323)2.03183808
112Hypoplasia of the thymus (HP:0000778)2.03095869
113Impaired platelet aggregation (HP:0003540)2.02794161
114Abnormal platelet function (HP:0011869)2.02794161
115Increased IgM level (HP:0003496)2.02744016
116Axonal loss (HP:0003447)2.01971695
117Keratoconjunctivitis (HP:0001096)2.01022858
118Severe combined immunodeficiency (HP:0004430)2.00760091
119Polyneuropathy (HP:0001271)1.99711734
120Granulocytopenia (HP:0001913)1.99625364
121Glomerulopathy (HP:0100820)1.99391480
122Skin ulcer (HP:0200042)1.98295801
123Keratitis (HP:0000491)1.98194293
124Abnormality of the pericardium (HP:0001697)1.94813254
125Vertigo (HP:0002321)1.94487635
126Thrombophlebitis (HP:0004418)1.94316656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06476974
2MAP3K143.34908592
3TYK23.04602488
4TXK3.01061234
5TAOK32.95739977
6ERN12.88448399
7IKBKE2.73408457
8TBK12.67441802
9IRAK42.53522943
10BLK2.48470013
11JAK32.43425412
12FGFR42.34039354
13KIT2.25731143
14JAK12.18509057
15IRAK32.12048551
16RIPK41.98577451
17ZAP701.94773709
18PRPF4B1.93748632
19BTK1.90305329
20IKBKB1.80574290
21TEC1.76155534
22FGR1.74597384
23MAP3K131.64333534
24TGFBR21.63380217
25SYK1.63377544
26EPHB11.60659302
27STK101.60453890
28CSK1.58618121
29CSF1R1.56739929
30FGFR31.40648943
31ITK1.40310315
32HCK1.35355679
33TAOK11.34978575
34GRK61.34504185
35NLK1.29184421
36CHUK1.26733236
37LCK1.26707772
38MAP3K111.21750834
39MST41.16140477
40PIM21.15048647
41LYN1.12323549
42ACVR1B1.09230676
43MAP3K101.06625309
44EPHA31.06427383
45PIM11.06135787
46TAOK21.05610618
47FES1.04348672
48TESK21.04248254
49JAK21.03334352
50SIK11.02225859
51MAP2K31.00635159
52NEK90.96345118
53KDR0.90368188
54CLK10.84665722
55SIK30.83835830
56FLT30.82898412
57MATK0.82303660
58PRKCQ0.82223071
59MST1R0.81656675
60LRRK20.81258281
61YES10.80672279
62MARK30.78066659
63SIK20.73804255
64NME20.73169151
65PIK3CG0.73042029
66TRPM70.70787059
67RPS6KA40.70140568
68KSR20.69962734
69MAPK110.69245877
70PTK60.69069031
71TIE10.67653127
72PTK2B0.67294441
73GRK70.66829855
74IRAK10.66335278
75CDC42BPA0.65413215
76MARK20.58382266
77TRIB30.58108912
78PRKCH0.57939546
79IRAK20.57766682
80FRK0.56540319
81STK40.55487554
82MAP3K50.55287037
83PDPK10.54970758
84CAMKK20.52916783
85HIPK20.52876079
86CAMK1D0.51673407
87TNK20.50733359
88MAP3K20.48940940
89ABL10.48249973
90PRKD20.47685860
91INSRR0.47276513
92NUAK10.46447830
93MAPK40.46383961
94PRKCD0.45906142
95MAP3K70.44940261
96PKN20.44612242
97ADRBK20.44536740
98MAP3K120.44002048
99MAP3K30.42178608
100EGFR0.41785014
101BMPR20.39850244
102RIPK10.39424331
103IGF1R0.39312277
104EEF2K0.38298018
105MAPKAPK20.38102890
106RPS6KA60.37302408
107SGK30.36690359
108BCKDK0.36599694
109GRK10.36437427
110CDK60.36215893
111PDK10.36100707
112PRKG20.35515615
113MAPK120.34914968
114MYLK0.34456756
115PRKAA20.34289634
116STK240.33388872
117MAP2K60.32741359
118MOS0.32360371
119MAPK70.31718255
120MAP3K10.30469445
121MAP2K20.28470221
122FYN0.28462771
123SGK20.28393899
124MAPK30.26286823
125RPS6KC10.26059859
126RPS6KL10.26059859
127SMG10.25934774
128CDK40.24950089
129RAF10.22347034
130BMX0.22001482

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.52993472
2Primary immunodeficiency_Homo sapiens_hsa053402.81677950
3Leishmaniasis_Homo sapiens_hsa051402.57713142
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.35748622
5Caffeine metabolism_Homo sapiens_hsa002322.33367749
6Complement and coagulation cascades_Homo sapiens_hsa046102.29013470
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.28303571
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.27542772
9Measles_Homo sapiens_hsa051622.09810946
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05070188
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00161260
12Osteoclast differentiation_Homo sapiens_hsa043801.98042498
13B cell receptor signaling pathway_Homo sapiens_hsa046621.95446090
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92059216
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82456572
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81963916
17Graft-versus-host disease_Homo sapiens_hsa053321.81174069
18Pertussis_Homo sapiens_hsa051331.74125752
19Allograft rejection_Homo sapiens_hsa053301.71253014
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67719347
21Hematopoietic cell lineage_Homo sapiens_hsa046401.66182739
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48977061
23Antigen processing and presentation_Homo sapiens_hsa046121.46972335
24Malaria_Homo sapiens_hsa051441.44144161
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42884008
26Tryptophan metabolism_Homo sapiens_hsa003801.40968783
27Influenza A_Homo sapiens_hsa051641.40334113
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.39121629
29ABC transporters_Homo sapiens_hsa020101.37731251
30Tuberculosis_Homo sapiens_hsa051521.37642388
31Other glycan degradation_Homo sapiens_hsa005111.34827218
32Legionellosis_Homo sapiens_hsa051341.34331070
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33360088
34Toxoplasmosis_Homo sapiens_hsa051451.32481957
35Herpes simplex infection_Homo sapiens_hsa051681.24943068
36Histidine metabolism_Homo sapiens_hsa003401.21589694
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20775856
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15317690
39T cell receptor signaling pathway_Homo sapiens_hsa046601.14601615
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14551276
41TNF signaling pathway_Homo sapiens_hsa046681.14039125
42Arginine biosynthesis_Homo sapiens_hsa002201.12942046
43Nitrogen metabolism_Homo sapiens_hsa009101.10137640
44Peroxisome_Homo sapiens_hsa041461.10112063
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.07740999
46Chemokine signaling pathway_Homo sapiens_hsa040621.07559737
47Hepatitis C_Homo sapiens_hsa051601.04656633
48Fatty acid degradation_Homo sapiens_hsa000711.03563041
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02985134
50Lysosome_Homo sapiens_hsa041420.97553126
51African trypanosomiasis_Homo sapiens_hsa051430.96728854
52PPAR signaling pathway_Homo sapiens_hsa033200.94838209
53Chemical carcinogenesis_Homo sapiens_hsa052040.94170775
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.93696881
55Asthma_Homo sapiens_hsa053100.91096964
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90262979
57Acute myeloid leukemia_Homo sapiens_hsa052210.89807188
58Apoptosis_Homo sapiens_hsa042100.89572269
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89006703
60Autoimmune thyroid disease_Homo sapiens_hsa053200.88328821
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86984704
62Starch and sucrose metabolism_Homo sapiens_hsa005000.85979986
63Shigellosis_Homo sapiens_hsa051310.84793021
64Hepatitis B_Homo sapiens_hsa051610.83988707
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.83988383
66Retinol metabolism_Homo sapiens_hsa008300.80522292
67Rheumatoid arthritis_Homo sapiens_hsa053230.79113760
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.77505471
69Salmonella infection_Homo sapiens_hsa051320.76690194
70Non-small cell lung cancer_Homo sapiens_hsa052230.73486965
71Platelet activation_Homo sapiens_hsa046110.73445653
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72899949
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72692743
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69354332
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69004325
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68654452
77Viral myocarditis_Homo sapiens_hsa054160.68456899
78beta-Alanine metabolism_Homo sapiens_hsa004100.67109847
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66942910
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64611873
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62528162
82Epstein-Barr virus infection_Homo sapiens_hsa051690.61339425
83Folate biosynthesis_Homo sapiens_hsa007900.58111726
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.57897521
85Sulfur relay system_Homo sapiens_hsa041220.57482774
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56457858
87VEGF signaling pathway_Homo sapiens_hsa043700.56173640
88Vitamin digestion and absorption_Homo sapiens_hsa049770.55629173
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.54376741
90Endocytosis_Homo sapiens_hsa041440.53744306
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52685872
92Insulin resistance_Homo sapiens_hsa049310.51730998
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51057029
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.50831829
95Phenylalanine metabolism_Homo sapiens_hsa003600.50524613
96Sulfur metabolism_Homo sapiens_hsa009200.50350380
97Type I diabetes mellitus_Homo sapiens_hsa049400.50071516
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.47284625
99HTLV-I infection_Homo sapiens_hsa051660.46818372
100Renal cell carcinoma_Homo sapiens_hsa052110.46798978
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46265218
102Prolactin signaling pathway_Homo sapiens_hsa049170.46172329
103Viral carcinogenesis_Homo sapiens_hsa052030.46025845
104Phagosome_Homo sapiens_hsa041450.43731719
105Chronic myeloid leukemia_Homo sapiens_hsa052200.42536534
106Bile secretion_Homo sapiens_hsa049760.41508256
107FoxO signaling pathway_Homo sapiens_hsa040680.41100305
108Systemic lupus erythematosus_Homo sapiens_hsa053220.40495460
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40127496
110Lysine degradation_Homo sapiens_hsa003100.40012405
111Pancreatic cancer_Homo sapiens_hsa052120.39040901
112Dorso-ventral axis formation_Homo sapiens_hsa043200.38216025
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38021709
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37131096
115Amoebiasis_Homo sapiens_hsa051460.35792546
116HIF-1 signaling pathway_Homo sapiens_hsa040660.35247167
117Fatty acid metabolism_Homo sapiens_hsa012120.35052935
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.34661625
119Fat digestion and absorption_Homo sapiens_hsa049750.33905248
120Selenocompound metabolism_Homo sapiens_hsa004500.33456556
121Renin-angiotensin system_Homo sapiens_hsa046140.33341021
122Regulation of autophagy_Homo sapiens_hsa041400.31071989
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29546074
124Collecting duct acid secretion_Homo sapiens_hsa049660.29239423
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28000051
126Arachidonic acid metabolism_Homo sapiens_hsa005900.27210832
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26934728
128GnRH signaling pathway_Homo sapiens_hsa049120.25739194
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24256266
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24154530
131Choline metabolism in cancer_Homo sapiens_hsa052310.23846660
132Notch signaling pathway_Homo sapiens_hsa043300.23620160
133Type II diabetes mellitus_Homo sapiens_hsa049300.23388577
134MAPK signaling pathway_Homo sapiens_hsa040100.20483817
135Endometrial cancer_Homo sapiens_hsa052130.18105430
136mTOR signaling pathway_Homo sapiens_hsa041500.18018034

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