IREB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.38149660
2nuclear pore organization (GO:0006999)4.29012972
3DNA topological change (GO:0006265)4.24390024
4nuclear pore complex assembly (GO:0051292)4.16215486
5DNA unwinding involved in DNA replication (GO:0006268)4.13554302
6regulation of gene silencing by RNA (GO:0060966)4.06715873
7regulation of posttranscriptional gene silencing (GO:0060147)4.06715873
8regulation of gene silencing by miRNA (GO:0060964)4.06715873
9pre-miRNA processing (GO:0031054)4.05967839
10regulation of centriole replication (GO:0046599)3.98285270
11cytoplasmic mRNA processing body assembly (GO:0033962)3.84067129
12negative regulation of DNA repair (GO:0045738)3.84024713
13mitotic sister chromatid cohesion (GO:0007064)3.83777437
14alpha-linolenic acid metabolic process (GO:0036109)3.78447030
15regulation of DNA endoreduplication (GO:0032875)3.77239234
16nucleobase catabolic process (GO:0046113)3.70571775
17L-phenylalanine catabolic process (GO:0006559)3.67820323
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67820323
19regulation of RNA export from nucleus (GO:0046831)3.62426989
20DNA duplex unwinding (GO:0032508)3.56340107
21regulation of DNA damage checkpoint (GO:2000001)3.51675971
22urea cycle (GO:0000050)3.51093548
23urea metabolic process (GO:0019627)3.51093548
24histone H2A monoubiquitination (GO:0035518)3.48640618
25DNA geometric change (GO:0032392)3.46221355
26regulation of histone H3-K9 methylation (GO:0051570)3.42216145
27negative regulation of histone methylation (GO:0031061)3.41394652
28regulation of sister chromatid cohesion (GO:0007063)3.40579257
29paraxial mesoderm development (GO:0048339)3.36282373
30regulation of hippo signaling (GO:0035330)3.32347507
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.32124541
32L-phenylalanine metabolic process (GO:0006558)3.32124541
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31076146
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.31076146
35regulation of translation, ncRNA-mediated (GO:0045974)3.31076146
36mitotic chromosome condensation (GO:0007076)3.26070851
37monoubiquitinated protein deubiquitination (GO:0035520)3.24806499
38sister chromatid cohesion (GO:0007062)3.22894253
39protein localization to chromosome, centromeric region (GO:0071459)3.22094898
40regulation of centrosome duplication (GO:0010824)3.20666096
41regulation of centrosome cycle (GO:0046605)3.20230101
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.18069392
43aromatic amino acid family catabolic process (GO:0009074)3.17163681
44serine family amino acid catabolic process (GO:0009071)3.16037461
45mitotic sister chromatid segregation (GO:0000070)3.15195986
46regulation of gene silencing (GO:0060968)3.13249853
47DNA replication-dependent nucleosome organization (GO:0034723)3.12375411
48DNA replication-dependent nucleosome assembly (GO:0006335)3.12375411
49glyoxylate metabolic process (GO:0046487)3.12144709
50gastrulation with mouth forming second (GO:0001702)3.10839553
51cysteine metabolic process (GO:0006534)3.09782131
52lysine metabolic process (GO:0006553)3.07210800
53lysine catabolic process (GO:0006554)3.07210800
54double-strand break repair via nonhomologous end joining (GO:0006303)3.05603785
55non-recombinational repair (GO:0000726)3.05603785
56homocysteine metabolic process (GO:0050667)3.05495944
57negative regulation of sterol transport (GO:0032372)3.03023649
58negative regulation of cholesterol transport (GO:0032375)3.03023649
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02778600
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.02778600
61nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.99464445
62glucocorticoid receptor signaling pathway (GO:0042921)2.99241161
63negative regulation of fibrinolysis (GO:0051918)2.99180810
64NLS-bearing protein import into nucleus (GO:0006607)2.98613319
65ribosome assembly (GO:0042255)2.97955637
66midgut development (GO:0007494)2.97738919
67positive regulation of DNA-templated transcription, initiation (GO:2000144)2.96832042
68ncRNA catabolic process (GO:0034661)2.96566350
69sulfur amino acid catabolic process (GO:0000098)2.96475530
70macroautophagy (GO:0016236)2.95712873
71kynurenine metabolic process (GO:0070189)2.95307062
72bile acid biosynthetic process (GO:0006699)2.94043585
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93981200
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93981200
75positive regulation of mitotic sister chromatid separation (GO:1901970)2.93981200
76positive regulation of histone H3-K4 methylation (GO:0051571)2.93464828
77nitrogen cycle metabolic process (GO:0071941)2.93271111
78mRNA transport (GO:0051028)2.91550108
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.90667879
80regulation of stem cell maintenance (GO:2000036)2.89113984
81anterior/posterior axis specification, embryo (GO:0008595)2.88947651
82negative regulation of smooth muscle cell differentiation (GO:0051151)2.87799871
83glycine metabolic process (GO:0006544)2.87766846
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86570715
85hippo signaling (GO:0035329)2.86477354
86regulation of protein activation cascade (GO:2000257)2.85733413
87regulation of nucleobase-containing compound transport (GO:0032239)2.85469509
88DNA conformation change (GO:0071103)2.85323777
89DNA replication checkpoint (GO:0000076)2.83322817
90ATP-dependent chromatin remodeling (GO:0043044)2.82705658
91high-density lipoprotein particle remodeling (GO:0034375)2.82114769
92histone H3-K9 demethylation (GO:0033169)2.81934797
93histone H2B ubiquitination (GO:0033523)2.81357006
94V(D)J recombination (GO:0033151)2.80704710
95regulation of chromatin silencing (GO:0031935)2.79526429
96DNA replication initiation (GO:0006270)2.78970142
97dosage compensation (GO:0007549)2.78459237
98dicarboxylic acid biosynthetic process (GO:0043650)2.76321611
99histone H3-K36 demethylation (GO:0070544)2.75343180
100rRNA catabolic process (GO:0016075)2.74947508
101chromatin remodeling at centromere (GO:0031055)2.74563016
102positive regulation of histone methylation (GO:0031062)2.74048565
103pore complex assembly (GO:0046931)2.71681639
104DNA replication-independent nucleosome organization (GO:0034724)2.71092419
105DNA replication-independent nucleosome assembly (GO:0006336)2.71092419
106heterochromatin organization (GO:0070828)2.70469176
107RNA transport (GO:0050658)2.70316852
108establishment of RNA localization (GO:0051236)2.70316852
109nucleic acid transport (GO:0050657)2.70316852
110protein carboxylation (GO:0018214)2.69515729
111peptidyl-glutamic acid carboxylation (GO:0017187)2.69515729
112tryptophan metabolic process (GO:0006568)2.69102452
113tryptophan catabolic process (GO:0006569)2.68576867
114indole-containing compound catabolic process (GO:0042436)2.68576867
115indolalkylamine catabolic process (GO:0046218)2.68576867
116positive regulation by host of viral transcription (GO:0043923)2.67986575
117regulation of fibrinolysis (GO:0051917)2.67856562
118histone H4-K5 acetylation (GO:0043981)2.67315476
119histone H4-K8 acetylation (GO:0043982)2.67315476
120histone lysine demethylation (GO:0070076)2.67305882
121regulation of histone methylation (GO:0031060)2.67126546
122protein localization to kinetochore (GO:0034501)2.66751260
123regulation of complement activation (GO:0030449)2.66457132
124histone-serine phosphorylation (GO:0035404)2.66408308
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.66402293
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.66306733
127DNA strand elongation involved in DNA replication (GO:0006271)2.66192965
128folic acid-containing compound biosynthetic process (GO:0009396)2.66174955
129regulation of histone H3-K27 methylation (GO:0061085)2.66045410
130regulation of histone H3-K4 methylation (GO:0051569)2.65604112
131stress granule assembly (GO:0034063)2.64440620
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64379703
133complement activation, alternative pathway (GO:0006957)2.64172088
134mRNA stabilization (GO:0048255)2.63707796
135RNA stabilization (GO:0043489)2.63707796
136corticosteroid receptor signaling pathway (GO:0031958)2.63087343
137CENP-A containing nucleosome assembly (GO:0034080)2.63072474
138DNA synthesis involved in DNA repair (GO:0000731)2.62286302
139histone H4-K16 acetylation (GO:0043984)2.62027815
140positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61830685
141drug catabolic process (GO:0042737)2.61733416
142mitotic G2/M transition checkpoint (GO:0044818)2.61629045
143regulation of DNA-templated transcription, initiation (GO:2000142)2.61610906
144regulation of telomere maintenance via telomerase (GO:0032210)2.61420323
145histone ubiquitination (GO:0016574)2.61236775
146embryonic foregut morphogenesis (GO:0048617)2.61059759
147bile acid metabolic process (GO:0008206)2.60939319
148RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60931621
149negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.60903306
150positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.58398144
151regulation of translational fidelity (GO:0006450)2.58393775
152histone H3-K9 methylation (GO:0051567)2.58227037
153regulation of nuclear cell cycle DNA replication (GO:0033262)2.57733094
154regulation of cholesterol homeostasis (GO:2000188)2.57561079
155reverse cholesterol transport (GO:0043691)2.57084156
156replication fork processing (GO:0031297)2.56955276
157one-carbon metabolic process (GO:0006730)2.56728234
158gene silencing by RNA (GO:0031047)2.56680484
159DNA strand elongation (GO:0022616)2.55195774
160alternative mRNA splicing, via spliceosome (GO:0000380)2.54934112
161positive regulation of SMAD protein import into nucleus (GO:0060391)2.54666343
162regulation of fatty acid beta-oxidation (GO:0031998)2.52954811
163serine family amino acid metabolic process (GO:0009069)2.52748268
164histone demethylation (GO:0016577)2.50878721
165positive regulation of chromosome segregation (GO:0051984)2.49184698
166peptidyl-lysine dimethylation (GO:0018027)2.46885163
167embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46788258
168COPII vesicle coating (GO:0048208)2.46286624
169Golgi transport vesicle coating (GO:0048200)2.45562098
170COPI coating of Golgi vesicle (GO:0048205)2.45562098
171sister chromatid segregation (GO:0000819)2.44244332
172polarized epithelial cell differentiation (GO:0030859)2.43601348
173nuclear envelope disassembly (GO:0051081)2.43127068
174membrane disassembly (GO:0030397)2.43127068
175mitotic nuclear envelope disassembly (GO:0007077)2.40933744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.85197048
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.67369839
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.38350110
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.31681079
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.39123157
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.23130327
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19390634
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.13650761
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79409984
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.79033767
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76842504
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.76123674
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.71402155
14FUS_26573619_Chip-Seq_HEK293_Human2.59024540
15AR_21909140_ChIP-Seq_LNCAP_Human2.42894459
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34050393
17EWS_26573619_Chip-Seq_HEK293_Human2.28799841
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.28671891
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.26930444
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.19602612
21CLOCK_20551151_ChIP-Seq_293T_Human2.13285055
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06814808
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03385034
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95062204
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93448634
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.93358020
27ELK1_19687146_ChIP-ChIP_HELA_Human1.90943763
28* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90230516
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89594551
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89475836
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89143975
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85122090
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84916682
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.84715069
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84364347
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83585394
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83585394
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83585394
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.78910424
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78154017
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75739600
42TAF15_26573619_Chip-Seq_HEK293_Human1.70828281
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69101003
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64280980
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.63611783
46* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61892584
47ZNF263_19887448_ChIP-Seq_K562_Human1.61882449
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59056175
49SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.59021275
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54925056
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53109947
52* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52447028
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.48541902
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47157563
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46910392
56* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44338983
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43435720
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42465172
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41924038
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41096478
61MYC_22102868_ChIP-Seq_BL_Human1.40702864
62CHD1_26751641_Chip-Seq_LNCaP_Human1.39977623
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.37921688
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37176457
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37139094
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34884628
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34433529
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33915586
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.32219603
70GATA1_22025678_ChIP-Seq_K562_Human1.31651851
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31454522
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30342983
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29673340
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29141377
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28883727
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26187923
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.24611657
78IGF1R_20145208_ChIP-Seq_DFB_Human1.23573177
79* NANOG_16518401_ChIP-PET_MESCs_Mouse1.23310929
80* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23202397
81* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22129491
82ZNF274_21170338_ChIP-Seq_K562_Hela1.20179058
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.19674901
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18582388
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18197470
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.17699683
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17404237
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16460169
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16107374
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.13772672
91* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12451283
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11634812
93* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11137803
94* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10947864
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10629039
96TTF2_22483619_ChIP-Seq_HELA_Human1.09039126
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.08987084
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08264770
99GATA6_25053715_ChIP-Seq_YYC3_Human1.07732935
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07455915
101SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07360791
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06970307
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06695060
104ER_23166858_ChIP-Seq_MCF-7_Human1.06215609
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.06025235
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.05840630
107P300_19829295_ChIP-Seq_ESCs_Human1.05510285
108KDM5A_27292631_Chip-Seq_BREAST_Human1.04241045
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04066152
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.03933631
111GBX2_23144817_ChIP-Seq_PC3_Human1.03778021
112FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03097768
113* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02021192
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01098870
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00861816
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00576086
117ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99536830
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99278630
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99240115
120* STAT3_23295773_ChIP-Seq_U87_Human0.99047562
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99045008
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98621987
123* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98407566
124* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97445613
125IRF1_19129219_ChIP-ChIP_H3396_Human0.97310296
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96889120
127MYC_18940864_ChIP-ChIP_HL60_Human0.96870321
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94622625
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94224929
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93911135
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93911135
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93668373
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93081808
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92472752
135* VDR_23849224_ChIP-Seq_CD4+_Human0.92046606
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91493894
137AR_21572438_ChIP-Seq_LNCaP_Human0.90493342
138VDR_22108803_ChIP-Seq_LS180_Human0.90343801
139FOXP3_21729870_ChIP-Seq_TREG_Human0.90225744
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90208474
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90143076
142* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89823452
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89529148
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89336341
145SOX9_26525672_Chip-Seq_HEART_Mouse0.88809169
146* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88088144
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87737032
148NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86344022
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.86216281
150EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84626361
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84544286
152CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84472652
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83570310
154GABP_17652178_ChIP-ChIP_JURKAT_Human0.81900315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.37647729
2MP0005360_urolithiasis4.36446479
3MP0005085_abnormal_gallbladder_physiolo3.32023296
4MP0005365_abnormal_bile_salt3.19637752
5MP0003705_abnormal_hypodermis_morpholog3.14362331
6MP0003890_abnormal_embryonic-extraembry2.90520293
7MP0003252_abnormal_bile_duct2.85900883
8MP0002009_preneoplasia2.78011403
9MP0010234_abnormal_vibrissa_follicle2.70852634
10MP0009053_abnormal_anal_canal2.40127968
11MP0010352_gastrointestinal_tract_polyps2.39990619
12MP0005076_abnormal_cell_differentiation2.36165686
13MP0008058_abnormal_DNA_repair2.35186306
14MP0000537_abnormal_urethra_morphology2.11698765
15MP0004264_abnormal_extraembryonic_tissu2.08858336
16MP0003123_paternal_imprinting2.07229399
17MP0008875_abnormal_xenobiotic_pharmacok2.01944581
18MP0000569_abnormal_digit_pigmentation2.01044594
19MP0003121_genomic_imprinting2.00395718
20MP0005187_abnormal_penis_morphology1.99049468
21MP0009697_abnormal_copulation1.97964134
22MP0003119_abnormal_digestive_system1.87695728
23MP0002084_abnormal_developmental_patter1.80615689
24MP0003806_abnormal_nucleotide_metabolis1.80386910
25MP0001849_ear_inflammation1.77465349
26MP0004197_abnormal_fetal_growth/weight/1.75150498
27MP0008932_abnormal_embryonic_tissue1.74092351
28MP0010329_abnormal_lipoprotein_level1.71692216
29MP0001730_embryonic_growth_arrest1.66140637
30MP0010307_abnormal_tumor_latency1.61181459
31MP0003941_abnormal_skin_development1.60543838
32MP0001661_extended_life_span1.58134966
33MP0009672_abnormal_birth_weight1.54793204
34MP0002396_abnormal_hematopoietic_system1.53461362
35MP0005380_embryogenesis_phenotype1.53437477
36MP0001672_abnormal_embryogenesis/_devel1.53437477
37MP0002085_abnormal_embryonic_tissue1.47305769
38MP0004185_abnormal_adipocyte_glucose1.46598323
39MP0002086_abnormal_extraembryonic_tissu1.46455071
40MP0003868_abnormal_feces_composition1.44700958
41MP0002088_abnormal_embryonic_growth/wei1.43326339
42MP0003984_embryonic_growth_retardation1.40410462
43MP0000350_abnormal_cell_proliferation1.40361012
44MP0010030_abnormal_orbit_morphology1.39518711
45MP0004957_abnormal_blastocyst_morpholog1.38963175
46MP0005248_abnormal_Harderian_gland1.38525936
47MP0001697_abnormal_embryo_size1.34606249
48MP0009703_decreased_birth_body1.32830403
49MP0003937_abnormal_limbs/digits/tail_de1.32389574
50MP0002877_abnormal_melanocyte_morpholog1.30169981
51MP0003111_abnormal_nucleus_morphology1.28673767
52MP0002653_abnormal_ependyma_morphology1.28476487
53MP0003283_abnormal_digestive_organ1.28241130
54MP0001666_abnormal_nutrient_absorption1.28104070
55MP0003567_abnormal_fetal_cardiomyocyte1.26468655
56MP0004808_abnormal_hematopoietic_stem1.25379156
57MP0003077_abnormal_cell_cycle1.25197646
58MP0010094_abnormal_chromosome_stability1.24757584
59MP0003115_abnormal_respiratory_system1.24212389
60MP0003122_maternal_imprinting1.22252970
61MP0008057_abnormal_DNA_replication1.21764562
62MP0003787_abnormal_imprinting1.20542270
63MP0009780_abnormal_chondrocyte_physiolo1.19053893
64MP0001188_hyperpigmentation1.14111669
65MP0002697_abnormal_eye_size1.12705756
66MP0003385_abnormal_body_wall1.10694086
67* MP0000609_abnormal_liver_physiology1.10374433
68MP0003943_abnormal_hepatobiliary_system1.10049655
69MP0003935_abnormal_craniofacial_develop1.09568827
70MP0000383_abnormal_hair_follicle1.09434845
71MP0003221_abnormal_cardiomyocyte_apopto1.07459952
72MP0002092_abnormal_eye_morphology1.07382970
73MP0004233_abnormal_muscle_weight1.07014045
74MP0002102_abnormal_ear_morphology1.06050552
75MP0003300_gastrointestinal_ulcer1.05106440
76MP0008961_abnormal_basal_metabolism1.04351193
77MP0001293_anophthalmia1.02596768
78MP0005367_renal/urinary_system_phenotyp1.01382398
79MP0000516_abnormal_urinary_system1.01382398
80MP0003136_yellow_coat_color1.00022211
81MP0001915_intracranial_hemorrhage0.99201140
82MP0003861_abnormal_nervous_system0.98935318
83MP0002080_prenatal_lethality0.98474381
84MP0003693_abnormal_embryo_hatching0.97988601
85MP0003755_abnormal_palate_morphology0.97386427
86MP0003942_abnormal_urinary_system0.96950602
87MP0002751_abnormal_autonomic_nervous0.93217373
88MP0000631_abnormal_neuroendocrine_gland0.92688041
89MP0000371_diluted_coat_color0.91840519
90MP0001286_abnormal_eye_development0.90894721
91MP0005332_abnormal_amino_acid0.90114172
92MP0000733_abnormal_muscle_development0.89470405
93MP0002938_white_spotting0.89440161
94MP0005666_abnormal_adipose_tissue0.89109803
95MP0002081_perinatal_lethality0.88830857
96MP0005220_abnormal_exocrine_pancreas0.86423170
97MP0005647_abnormal_sex_gland0.86200166
98MP0000313_abnormal_cell_death0.85669247
99MP0002160_abnormal_reproductive_system0.84945792
100MP0000428_abnormal_craniofacial_morphol0.84269239
101MP0004133_heterotaxia0.83540430
102MP0002111_abnormal_tail_morphology0.83203524
103MP0000432_abnormal_head_morphology0.79769784
104MP0002118_abnormal_lipid_homeostasis0.79734025
105MP0005083_abnormal_biliary_tract0.78171913
106MP0000598_abnormal_liver_morphology0.77343600
107MP0002233_abnormal_nose_morphology0.75599175
108MP0002249_abnormal_larynx_morphology0.74952707
109MP0000462_abnormal_digestive_system0.74673124
110MP0000534_abnormal_ureter_morphology0.74417684
111MP0002075_abnormal_coat/hair_pigmentati0.73383572
112MP0002925_abnormal_cardiovascular_devel0.72441464
113MP0002138_abnormal_hepatobiliary_system0.71572204
114MP0005174_abnormal_tail_pigmentation0.71440808
115MP0006054_spinal_hemorrhage0.70704169
116MP0010630_abnormal_cardiac_muscle0.70598102
117MP0008995_early_reproductive_senescence0.70215021
118MP0008007_abnormal_cellular_replicative0.70051393
119MP0002282_abnormal_trachea_morphology0.69432278
120MP0004885_abnormal_endolymph0.69166368
121MP0001919_abnormal_reproductive_system0.69143969
122MP0008877_abnormal_DNA_methylation0.69024019
123MP0000647_abnormal_sebaceous_gland0.68373254
124* MP0002114_abnormal_axial_skeleton0.68175993
125MP0003718_maternal_effect0.67988266
126MP0001145_abnormal_male_reproductive0.66960149
127MP0003646_muscle_fatigue0.65730717
128MP0000266_abnormal_heart_morphology0.64770668
129MP0001186_pigmentation_phenotype0.64249705
130MP0001324_abnormal_eye_pigmentation0.63896925
131MP0003315_abnormal_perineum_morphology0.63465854
132MP0002109_abnormal_limb_morphology0.63169222
133MP0002932_abnormal_joint_morphology0.62966193
134MP0002928_abnormal_bile_duct0.62648457
135MP0002896_abnormal_bone_mineralization0.61902178
136MP0008770_decreased_survivor_rate0.61653420
137MP0000778_abnormal_nervous_system0.61581400
138MP0010678_abnormal_skin_adnexa0.61400041
139MP0002210_abnormal_sex_determination0.61163201

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26090261
2Chromsome breakage (HP:0040012)4.07027450
3Deep venous thrombosis (HP:0002625)3.83437078
4Intrahepatic cholestasis (HP:0001406)3.59926238
5Cortical dysplasia (HP:0002539)3.59312272
6Birth length less than 3rd percentile (HP:0003561)3.50847685
7Hypochromic microcytic anemia (HP:0004840)3.15315369
8Hypobetalipoproteinemia (HP:0003563)3.13804438
9Nephroblastoma (Wilms tumor) (HP:0002667)3.11556237
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.06916894
11Embryonal renal neoplasm (HP:0011794)3.03981143
12Abnormality of chromosome stability (HP:0003220)2.96622806
13Hepatoblastoma (HP:0002884)2.96213344
14Papillary thyroid carcinoma (HP:0002895)2.94456122
15Astrocytoma (HP:0009592)2.92688608
16Abnormality of the astrocytes (HP:0100707)2.92688608
17Epidermoid cyst (HP:0200040)2.81175380
18Ependymoma (HP:0002888)2.80412278
19Heterotopia (HP:0002282)2.79753479
20Spastic diplegia (HP:0001264)2.65130136
21Subacute progressive viral hepatitis (HP:0006572)2.63916355
22Short 4th metacarpal (HP:0010044)2.59711458
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59711458
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.58312401
25Facial hemangioma (HP:0000329)2.51130731
26Macroorchidism (HP:0000053)2.50966128
27Partial agenesis of the corpus callosum (HP:0001338)2.50623187
28Pseudobulbar signs (HP:0002200)2.49600214
29Curly hair (HP:0002212)2.47710100
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45792566
31Meckel diverticulum (HP:0002245)2.45123782
32Abnormality of the lower motor neuron (HP:0002366)2.43747892
33Abnormality of sulfur amino acid metabolism (HP:0004339)2.39860538
34Neoplasm of the adrenal cortex (HP:0100641)2.39630506
35Skull defect (HP:0001362)2.38960814
36Asymmetry of the thorax (HP:0001555)2.38146211
37Abnormality of the ileum (HP:0001549)2.37382986
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.36731142
39Abnormality of the labia minora (HP:0012880)2.35231906
40Acute myeloid leukemia (HP:0004808)2.35185998
41Hepatocellular carcinoma (HP:0001402)2.32327982
42Abnormality of the 4th metacarpal (HP:0010012)2.31966426
43Xanthomatosis (HP:0000991)2.30605146
44Back pain (HP:0003418)2.30316894
45Complement deficiency (HP:0004431)2.27938159
46Protruding tongue (HP:0010808)2.24691413
47Hypolipoproteinemia (HP:0010981)2.24456194
48Absent eyebrow (HP:0002223)2.22410646
49Hyperglycemia (HP:0003074)2.22391531
50Volvulus (HP:0002580)2.20676787
51Missing ribs (HP:0000921)2.20242262
52Shawl scrotum (HP:0000049)2.19764492
53Glioma (HP:0009733)2.18967893
54Insidious onset (HP:0003587)2.18364336
55Termporal pattern (HP:0011008)2.18364336
56Bilateral microphthalmos (HP:0007633)2.16654007
57Cystic hygroma (HP:0000476)2.15722764
58Ectopic kidney (HP:0000086)2.13411249
59Neoplasm of the oral cavity (HP:0100649)2.11565913
60Deep philtrum (HP:0002002)2.11489253
61Abnormality of the preputium (HP:0100587)2.10944868
62Lymphangioma (HP:0100764)2.10112026
63Colon cancer (HP:0003003)2.08750220
64Midline defect of the nose (HP:0004122)2.08592507
65Biliary tract neoplasm (HP:0100574)2.07401277
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05855961
67Bifid tongue (HP:0010297)2.04542669
68Abnormality of the common coagulation pathway (HP:0010990)2.04260045
69Abnormal lung lobation (HP:0002101)2.03380816
70Medulloblastoma (HP:0002885)2.02543305
71Abnormal pancreas size (HP:0012094)2.01988229
72Diastasis recti (HP:0001540)2.01943729
73Gastrointestinal carcinoma (HP:0002672)2.01389093
74Malignant gastrointestinal tract tumors (HP:0006749)2.01389093
75Rhabdomyosarcoma (HP:0002859)2.00792196
76Cafe-au-lait spot (HP:0000957)2.00695097
77Abnormality of the nasal septum (HP:0000419)1.99591112
78Neonatal hypoglycemia (HP:0001998)1.99514603
79Duplicated collecting system (HP:0000081)1.98838081
80Genetic anticipation (HP:0003743)1.97652603
81Myelodysplasia (HP:0002863)1.97442015
82Abnormality of the carotid arteries (HP:0005344)1.94192878
83Renovascular hypertension (HP:0100817)1.93741801
84Clubbing of toes (HP:0100760)1.93184869
85Drooling (HP:0002307)1.92875299
86Hypoglycemic coma (HP:0001325)1.92412260
87Duodenal stenosis (HP:0100867)1.91911827
88Small intestinal stenosis (HP:0012848)1.91911827
89Neoplasm of striated muscle (HP:0009728)1.89026041
90Absent radius (HP:0003974)1.87947618
91Transitional cell carcinoma of the bladder (HP:0006740)1.86853372
92Hypoalphalipoproteinemia (HP:0003233)1.85699344
93Patellar aplasia (HP:0006443)1.84970217
94Abnormality of the intrinsic pathway (HP:0010989)1.84844162
95Enlarged penis (HP:0000040)1.82689003
96Truncal obesity (HP:0001956)1.82433165
97Sloping forehead (HP:0000340)1.81846664
98Abnormal hair whorl (HP:0010721)1.81516264
99Pheochromocytoma (HP:0002666)1.81355532
100Hypoglycemic seizures (HP:0002173)1.80495522
101Abnormality of homocysteine metabolism (HP:0010919)1.80102096
102Homocystinuria (HP:0002156)1.80102096
103Hyperglycinemia (HP:0002154)1.79989589
104High anterior hairline (HP:0009890)1.79702087
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79247010
106Sandal gap (HP:0001852)1.78906438
107Absent forearm bone (HP:0003953)1.78197830
108Aplasia involving forearm bones (HP:0009822)1.78197830
109Abnormal biliary tract morphology (HP:0012440)1.78189886
110Acute lymphatic leukemia (HP:0006721)1.77918834
111Impulsivity (HP:0100710)1.75012640
112Embryonal neoplasm (HP:0002898)1.74907464
113Neoplasm of the small intestine (HP:0100833)1.73985358
114Abnormality of the pons (HP:0007361)1.73920680
115Turricephaly (HP:0000262)1.73467756
116Abnormality of pyrimidine metabolism (HP:0004353)1.73286156
117Renal duplication (HP:0000075)1.72141435
118Prolonged partial thromboplastin time (HP:0003645)1.71679726
119Increased nuchal translucency (HP:0010880)1.71409202
120Abnormality of the duodenum (HP:0002246)1.70880185
121Bladder carcinoma (HP:0002862)1.70879728
122Bladder neoplasm (HP:0009725)1.70879728
123Aqueductal stenosis (HP:0002410)1.69606870
124Neoplasm of the thyroid gland (HP:0100031)1.68902165
125Abnormality of the renal collecting system (HP:0004742)1.68581547
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68546756
127Cutis marmorata (HP:0000965)1.68461947
128Intestinal polyposis (HP:0200008)1.68325484
129Excessive salivation (HP:0003781)1.68170630
130Abnormality of the fingertips (HP:0001211)1.68048816
131Intestinal polyp (HP:0005266)1.67684358
132Cutaneous finger syndactyly (HP:0010554)1.67564501
133Abnormality of the diencephalon (HP:0010662)1.67402271
134Deviation of the thumb (HP:0009603)1.67319192
135Aplasia/Hypoplasia of the patella (HP:0006498)1.66446331
136Neoplasm of the liver (HP:0002896)1.65914789
137Fibrous tissue neoplasm (HP:0012316)1.65309390
138Proximal placement of thumb (HP:0009623)1.65302166
139Meningioma (HP:0002858)1.64992825
140Hypoplastic labia majora (HP:0000059)1.64841962
1412-3 toe syndactyly (HP:0004691)1.64680113
142Hyperglycinuria (HP:0003108)1.64638287
143Broad thumb (HP:0011304)1.64452424
144Uterine neoplasm (HP:0010784)1.64270892
145Thyroid carcinoma (HP:0002890)1.64229955
146Vertebral clefting (HP:0008428)1.63576034
147Amyotrophic lateral sclerosis (HP:0007354)1.63438089
148Spontaneous abortion (HP:0005268)1.63125512
149Skin nodule (HP:0200036)1.62744698
150Anal stenosis (HP:0002025)1.62149237
151Myelomeningocele (HP:0002475)1.61991137
152Wide intermamillary distance (HP:0006610)1.60300768
153Uterine leiomyosarcoma (HP:0002891)1.59825944
154Leiomyosarcoma (HP:0100243)1.59825944
155Overlapping toe (HP:0001845)1.59078046
156Progressive external ophthalmoplegia (HP:0000590)1.58932904
157Obsessive-compulsive behavior (HP:0000722)1.58763016
158Short 1st metacarpal (HP:0010034)1.58651086
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58651086
160Fibroma (HP:0010614)1.58291075
161Delayed puberty (HP:0000823)1.58003410
162Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57312727
163Hyperinsulinemic hypoglycemia (HP:0000825)1.57267024
164Abnormality of chromosome segregation (HP:0002916)1.57150302
165Hyperammonemia (HP:0001987)1.56763077
166Hyperacusis (HP:0010780)1.55705686
167Hypercholesterolemia (HP:0003124)1.55346440
168Esophageal varix (HP:0002040)1.54684953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.70033840
2CDK123.74992089
3MKNK23.20843010
4TAF13.16328623
5LATS22.88975265
6PKN22.64620635
7CDC72.38933713
8TSSK62.21031010
9TRIB32.10584720
10TNIK2.08771502
11SRPK11.93457866
12MARK11.88442354
13KSR11.82435925
14STK31.80867505
15FRK1.80355525
16STK38L1.77958936
17CDK61.77024316
18MAP3K101.75946029
19SCYL21.75764433
20BRD41.73558800
21PDGFRA1.70333481
22BRSK21.64592503
23ERBB41.62410650
24NEK11.58051220
25EIF2AK31.57114608
26FGFR21.55488929
27ERBB31.54372374
28PLK41.47804255
29NEK21.45885297
30PTK61.41730125
31ICK1.39010750
32TYRO31.38574597
33TTK1.38443001
34MELK1.32600010
35EEF2K1.32049997
36MTOR1.27507391
37KSR21.27174502
38ZAK1.26332270
39CAMK1D1.21753183
40ACVR1B1.21240340
41MAP3K41.18338608
42SIK11.16904162
43CASK1.15147563
44RET1.13266105
45MAP3K91.07830424
46FGFR41.06161194
47MAP2K41.05339087
48BMPR1B1.04355628
49CDK41.04154513
50DYRK21.03902022
51ALK1.00473577
52CHEK21.00236937
53CAMK1G0.99795398
54MET0.94994931
55TRIM280.92663955
56EIF2AK10.92553660
57MAP3K20.92310791
58CHEK10.91686900
59FGFR10.90260977
60AKT30.89196968
61EIF2AK20.87984320
62PIK3CA0.87425073
63PASK0.85328634
64YES10.84550615
65PLK30.84511584
66MAP3K60.82192258
67SMG10.81426582
68BCR0.81393124
69WNK10.81231609
70TAOK30.79147197
71PDGFRB0.79034855
72RIPK10.78758900
73FLT30.77540371
74PRKD30.77266772
75PAK60.76950695
76EPHA20.76885342
77ATM0.76255081
78STK240.75812955
79FGFR30.75095434
80CDK30.74923722
81WNK30.74096479
82RPS6KA40.73546354
83TGFBR10.72820075
84ATR0.71836918
85ERBB20.70908146
86DDR20.69781109
87NLK0.69038182
88PRKAA10.68385004
89BUB10.68236736
90PAK30.67889520
91PLK10.67495898
92CSNK1D0.67188209
93* CDK20.67165866
94PTK20.66628343
95RPS6KB10.66484920
96MKNK10.65744438
97CDK90.65435743
98SGK30.64520187
99RPS6KB20.64335619
100PNCK0.63738912
101MAP3K80.63475105
102CSNK1A1L0.59995802
103EPHB20.59994927
104PBK0.59974358
105* CDK10.58741497
106STK390.58645959
107DYRK1B0.58603239
108MAP3K140.56675401
109DYRK30.55614049
110CDK70.55586563
111CSNK1G20.55578382
112CSNK1E0.54557369
113SGK20.52714417
114WNK40.52409392
115PDK30.51294122
116PDK40.51294122
117CLK10.51190798
118GSK3A0.49934671
119STK380.49791488
120STK100.49747054
121TEC0.46107447
122IRAK10.45459868
123ERN10.45353223
124WEE10.45327444
125STK40.45071649
126FER0.44983429
127CSNK1G10.44556170
128NUAK10.44176602
129VRK10.43913078
130PAK20.42690849
131PRKDC0.41959773
132MAPK140.41806713
133AURKB0.41097848
134DYRK1A0.39323118
135NEK90.37362672
136RAF10.35876076

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.51016856
2Non-homologous end-joining_Homo sapiens_hsa034503.41228360
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.11300492
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78344524
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70417518
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68457111
7DNA replication_Homo sapiens_hsa030302.56758357
8Arginine biosynthesis_Homo sapiens_hsa002202.46623841
9Spliceosome_Homo sapiens_hsa030402.44238494
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43787578
11RNA degradation_Homo sapiens_hsa030182.16651275
12Lysine degradation_Homo sapiens_hsa003102.14328783
13Mismatch repair_Homo sapiens_hsa034302.13036873
14Selenocompound metabolism_Homo sapiens_hsa004502.10896643
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.09038975
16Fanconi anemia pathway_Homo sapiens_hsa034602.06756449
17Tryptophan metabolism_Homo sapiens_hsa003802.00150132
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96299612
19Homologous recombination_Homo sapiens_hsa034401.92240142
20Basal transcription factors_Homo sapiens_hsa030221.84722157
21Butanoate metabolism_Homo sapiens_hsa006501.82314693
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.79908721
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70109338
24Complement and coagulation cascades_Homo sapiens_hsa046101.69773120
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68622169
26Nucleotide excision repair_Homo sapiens_hsa034201.66683091
27Fatty acid degradation_Homo sapiens_hsa000711.61934370
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47390844
29One carbon pool by folate_Homo sapiens_hsa006701.40363784
30mTOR signaling pathway_Homo sapiens_hsa041501.38488099
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36100100
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29738910
33Bile secretion_Homo sapiens_hsa049761.26928844
34Fatty acid metabolism_Homo sapiens_hsa012121.25787450
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23539768
36PPAR signaling pathway_Homo sapiens_hsa033201.23096087
37Endometrial cancer_Homo sapiens_hsa052131.19260663
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.17236496
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17090100
40Fat digestion and absorption_Homo sapiens_hsa049751.15276124
41Biosynthesis of amino acids_Homo sapiens_hsa012301.11275481
42Adherens junction_Homo sapiens_hsa045201.11259780
43Hippo signaling pathway_Homo sapiens_hsa043901.10986043
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08526554
45TGF-beta signaling pathway_Homo sapiens_hsa043501.06550895
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05415325
47Melanoma_Homo sapiens_hsa052181.04606752
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.04246733
49mRNA surveillance pathway_Homo sapiens_hsa030151.03145869
50Base excision repair_Homo sapiens_hsa034101.00970865
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99689301
52Cell cycle_Homo sapiens_hsa041100.99470005
53Insulin resistance_Homo sapiens_hsa049310.97779472
54MicroRNAs in cancer_Homo sapiens_hsa052060.97097747
55Viral carcinogenesis_Homo sapiens_hsa052030.95953903
56AMPK signaling pathway_Homo sapiens_hsa041520.95050015
57Colorectal cancer_Homo sapiens_hsa052100.94726477
58Propanoate metabolism_Homo sapiens_hsa006400.92864707
59Caffeine metabolism_Homo sapiens_hsa002320.91741075
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90663020
61Starch and sucrose metabolism_Homo sapiens_hsa005000.89014999
62Inositol phosphate metabolism_Homo sapiens_hsa005620.88611928
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.87983676
64Sulfur metabolism_Homo sapiens_hsa009200.85941641
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85039658
66Acute myeloid leukemia_Homo sapiens_hsa052210.85020491
67Chemical carcinogenesis_Homo sapiens_hsa052040.83476506
68RNA transport_Homo sapiens_hsa030130.83085269
69Retinol metabolism_Homo sapiens_hsa008300.83057941
70Pyruvate metabolism_Homo sapiens_hsa006200.82309149
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.81989469
72Chronic myeloid leukemia_Homo sapiens_hsa052200.80718629
73Basal cell carcinoma_Homo sapiens_hsa052170.80569444
74Peroxisome_Homo sapiens_hsa041460.80061810
75Choline metabolism in cancer_Homo sapiens_hsa052310.79809399
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76721034
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76159106
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75171130
79Glucagon signaling pathway_Homo sapiens_hsa049220.74602460
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72035118
81RNA polymerase_Homo sapiens_hsa030200.71921420
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71363928
83Prostate cancer_Homo sapiens_hsa052150.70452313
84Carbon metabolism_Homo sapiens_hsa012000.70433270
85Type II diabetes mellitus_Homo sapiens_hsa049300.70372655
86beta-Alanine metabolism_Homo sapiens_hsa004100.68648242
87Non-small cell lung cancer_Homo sapiens_hsa052230.68605950
88Dorso-ventral axis formation_Homo sapiens_hsa043200.68112109
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66826284
90Pancreatic cancer_Homo sapiens_hsa052120.66475457
91Fatty acid biosynthesis_Homo sapiens_hsa000610.64494743
92FoxO signaling pathway_Homo sapiens_hsa040680.64026109
93Insulin signaling pathway_Homo sapiens_hsa049100.63839443
94Small cell lung cancer_Homo sapiens_hsa052220.63011250
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62944471
96Histidine metabolism_Homo sapiens_hsa003400.62628605
97ABC transporters_Homo sapiens_hsa020100.60728464
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60655011
99Oocyte meiosis_Homo sapiens_hsa041140.59865143
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59718649
101Hepatitis B_Homo sapiens_hsa051610.59116875
102Renal cell carcinoma_Homo sapiens_hsa052110.58326375
103Glioma_Homo sapiens_hsa052140.57928759
104Bladder cancer_Homo sapiens_hsa052190.57891504
105Proteoglycans in cancer_Homo sapiens_hsa052050.57375662
106Pathways in cancer_Homo sapiens_hsa052000.56417992
107Long-term depression_Homo sapiens_hsa047300.54339676
108Tight junction_Homo sapiens_hsa045300.53099169
109Phenylalanine metabolism_Homo sapiens_hsa003600.52899969
110Prolactin signaling pathway_Homo sapiens_hsa049170.52857678
111Thyroid cancer_Homo sapiens_hsa052160.52709353
112B cell receptor signaling pathway_Homo sapiens_hsa046620.51057424
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51012398
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50486543
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49521895
116Steroid biosynthesis_Homo sapiens_hsa001000.47708056
117Hedgehog signaling pathway_Homo sapiens_hsa043400.47156025
118Notch signaling pathway_Homo sapiens_hsa043300.47063389
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46337194
120Vitamin digestion and absorption_Homo sapiens_hsa049770.45193012
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.42940859
122Prion diseases_Homo sapiens_hsa050200.42881306
123Vitamin B6 metabolism_Homo sapiens_hsa007500.42327416
124T cell receptor signaling pathway_Homo sapiens_hsa046600.41745350
125Staphylococcus aureus infection_Homo sapiens_hsa051500.41286107
126ErbB signaling pathway_Homo sapiens_hsa040120.40417903
127p53 signaling pathway_Homo sapiens_hsa041150.38985999
128Epstein-Barr virus infection_Homo sapiens_hsa051690.37580101
129Tyrosine metabolism_Homo sapiens_hsa003500.37551132
130Alcoholism_Homo sapiens_hsa050340.37538952
131Estrogen signaling pathway_Homo sapiens_hsa049150.37116152
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35527477
133Wnt signaling pathway_Homo sapiens_hsa043100.34618904
134Focal adhesion_Homo sapiens_hsa045100.34329394
135HTLV-I infection_Homo sapiens_hsa051660.32617840
136Gap junction_Homo sapiens_hsa045400.31273429
137Thyroid hormone synthesis_Homo sapiens_hsa049180.28044975
138Long-term potentiation_Homo sapiens_hsa047200.26732771
139HIF-1 signaling pathway_Homo sapiens_hsa040660.25302160
140Hepatitis C_Homo sapiens_hsa051600.23342203
141Melanogenesis_Homo sapiens_hsa049160.22756947
142Axon guidance_Homo sapiens_hsa043600.22592574

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