IRAK1BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.49597976
2epithelial cilium movement (GO:0003351)5.27222678
3cilium movement (GO:0003341)5.00310403
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.69022348
5axonemal dynein complex assembly (GO:0070286)4.53676127
6intraciliary transport (GO:0042073)4.49804879
7behavioral response to nicotine (GO:0035095)4.43333269
8response to pheromone (GO:0019236)4.43182702
9protein localization to synapse (GO:0035418)4.33445563
10motile cilium assembly (GO:0044458)4.27316620
11neuron cell-cell adhesion (GO:0007158)4.25976356
12vocalization behavior (GO:0071625)4.08898655
13synaptic vesicle exocytosis (GO:0016079)4.04265566
14cell wall macromolecule catabolic process (GO:0016998)3.88467741
15cell wall macromolecule metabolic process (GO:0044036)3.88467741
16GTP biosynthetic process (GO:0006183)3.88032354
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87870336
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.80390909
19postsynaptic membrane organization (GO:0001941)3.76335704
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65961301
21regulation of cilium movement (GO:0003352)3.65331018
22protein localization to cilium (GO:0061512)3.62429463
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61982945
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.52826370
25sperm motility (GO:0030317)3.51963183
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51631772
27presynaptic membrane assembly (GO:0097105)3.50830612
28protein K11-linked deubiquitination (GO:0035871)3.46400510
29acrosome reaction (GO:0007340)3.45468602
30UTP biosynthetic process (GO:0006228)3.38564605
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.37916737
32calcium ion-dependent exocytosis (GO:0017156)3.36643326
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36627895
34retinal cone cell development (GO:0046549)3.36530516
35nephron tubule morphogenesis (GO:0072078)3.34616077
36nephron epithelium morphogenesis (GO:0072088)3.34616077
37neuron-neuron synaptic transmission (GO:0007270)3.32154216
38positive regulation of synapse maturation (GO:0090129)3.31998707
39synaptic transmission, glutamatergic (GO:0035249)3.30769085
40regulation of glutamate receptor signaling pathway (GO:1900449)3.30336236
41neuron fate determination (GO:0048664)3.29644705
42regulation of synaptic vesicle exocytosis (GO:2000300)3.29442810
43glutamate receptor signaling pathway (GO:0007215)3.26824373
44glutamate secretion (GO:0014047)3.26343232
45indolalkylamine metabolic process (GO:0006586)3.25327655
46axoneme assembly (GO:0035082)3.24237160
47acrosome assembly (GO:0001675)3.21792530
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.21743723
49fucose catabolic process (GO:0019317)3.20523345
50L-fucose metabolic process (GO:0042354)3.20523345
51L-fucose catabolic process (GO:0042355)3.20523345
52neuron recognition (GO:0008038)3.18869148
53tryptophan catabolic process (GO:0006569)3.16788773
54indole-containing compound catabolic process (GO:0042436)3.16788773
55indolalkylamine catabolic process (GO:0046218)3.16788773
56rRNA catabolic process (GO:0016075)3.14275645
57neuronal action potential propagation (GO:0019227)3.12752020
58nucleoside diphosphate phosphorylation (GO:0006165)3.12536272
59neural tube formation (GO:0001841)3.11012510
60guanosine-containing compound biosynthetic process (GO:1901070)3.10795564
61neurotransmitter-gated ion channel clustering (GO:0072578)3.10133258
62water-soluble vitamin biosynthetic process (GO:0042364)3.09954555
63behavioral response to ethanol (GO:0048149)3.09362732
64ventricular system development (GO:0021591)3.08726886
65detection of calcium ion (GO:0005513)3.08625630
66replication fork processing (GO:0031297)3.07867749
67negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07341064
68regulation of protein kinase A signaling (GO:0010738)3.04669654
69response to histamine (GO:0034776)3.04476782
70regulation of synaptic vesicle transport (GO:1902803)3.03852347
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02717854
72presynaptic membrane organization (GO:0097090)3.01526718
73photoreceptor cell maintenance (GO:0045494)3.01208601
74fusion of sperm to egg plasma membrane (GO:0007342)3.00983003
75negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.00893219
76positive regulation of synapse assembly (GO:0051965)2.99210370
77detection of light stimulus involved in visual perception (GO:0050908)2.97538619
78detection of light stimulus involved in sensory perception (GO:0050962)2.97538619
79cellular ketone body metabolic process (GO:0046950)2.96343016
80startle response (GO:0001964)2.95143603
81centriole replication (GO:0007099)2.90939399
82negative regulation of astrocyte differentiation (GO:0048712)2.89645886
83neuronal action potential (GO:0019228)2.89134279
84protein K6-linked ubiquitination (GO:0085020)2.87979747
85spermatid development (GO:0007286)2.87390783
86kynurenine metabolic process (GO:0070189)2.87214303
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83201302
88piRNA metabolic process (GO:0034587)2.82990116
89neurotransmitter secretion (GO:0007269)2.82142043
90cilium assembly (GO:0042384)2.82003190
91regulation of synapse maturation (GO:0090128)2.81588004
92UTP metabolic process (GO:0046051)2.81479156
93regulation of microtubule-based movement (GO:0060632)2.81370249
94locomotory exploration behavior (GO:0035641)2.80645237
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79991600
96cilium organization (GO:0044782)2.79924767
97male meiosis I (GO:0007141)2.79005047
98negative regulation of oligodendrocyte differentiation (GO:0048715)2.76219682
99respiratory chain complex IV assembly (GO:0008535)2.76174220
100sperm-egg recognition (GO:0035036)2.75965037
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75803487
102inner ear receptor stereocilium organization (GO:0060122)2.75710827
103cilium morphogenesis (GO:0060271)2.74570490
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.74344124
105regulation of translation, ncRNA-mediated (GO:0045974)2.74344124
106negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74344124
107regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73949539
108tryptophan metabolic process (GO:0006568)2.73814261
109left/right pattern formation (GO:0060972)2.73748939
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.73434702
111gamma-aminobutyric acid transport (GO:0015812)2.72373694
112reciprocal meiotic recombination (GO:0007131)2.72101457
113reciprocal DNA recombination (GO:0035825)2.72101457
114reflex (GO:0060004)2.71094056
115exploration behavior (GO:0035640)2.68786083
116CTP biosynthetic process (GO:0006241)2.68616918
117CTP metabolic process (GO:0046036)2.68616918
118DNA double-strand break processing (GO:0000729)2.68229077
119NADH dehydrogenase complex assembly (GO:0010257)2.67911261
120mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67911261
121mitochondrial respiratory chain complex I assembly (GO:0032981)2.67911261
122photoreceptor cell development (GO:0042461)2.67295081
123ketone body metabolic process (GO:1902224)2.67156715
124axonal fasciculation (GO:0007413)2.66669791
125plasma membrane fusion (GO:0045026)2.66024331
126nonmotile primary cilium assembly (GO:0035058)2.65824690
127male meiosis (GO:0007140)2.64880550
128behavioral defense response (GO:0002209)2.64645911
129behavioral fear response (GO:0001662)2.64645911
130cornea development in camera-type eye (GO:0061303)2.64422423
131auditory receptor cell stereocilium organization (GO:0060088)2.64403656
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64297093
133spermatid nucleus differentiation (GO:0007289)2.63878049
134cerebral cortex radially oriented cell migration (GO:0021799)2.63547058
135regulation of vesicle fusion (GO:0031338)2.62436570
136transmission of nerve impulse (GO:0019226)2.61220891
137renal tubule morphogenesis (GO:0061333)2.60481938
138preassembly of GPI anchor in ER membrane (GO:0016254)2.60007905
139ATP hydrolysis coupled proton transport (GO:0015991)2.59801883
140energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59801883
141indole-containing compound metabolic process (GO:0042430)2.59579053
142hindbrain development (GO:0030902)2.59109908
143protein complex biogenesis (GO:0070271)2.58914260
144auditory receptor cell differentiation (GO:0042491)2.58460763
145prenylation (GO:0097354)2.58323097
146protein prenylation (GO:0018342)2.58323097
147synapsis (GO:0007129)2.58168011
148regulation of neuronal synaptic plasticity (GO:0048168)2.57954873
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.57686275
150regulation of postsynaptic membrane potential (GO:0060078)2.57190543
151striatum development (GO:0021756)2.55476379
152embryonic epithelial tube formation (GO:0001838)2.55304952
153otic vesicle formation (GO:0030916)2.54921659
154somite development (GO:0061053)2.53696522
155smoothened signaling pathway (GO:0007224)2.53293490
156long-term synaptic potentiation (GO:0060291)2.52918798
157regulation of synaptic transmission, glutamatergic (GO:0051966)2.52834305
158positive regulation of membrane potential (GO:0045838)2.52471303
159synapse assembly (GO:0007416)2.52268133
160pyrimidine nucleobase catabolic process (GO:0006208)2.51847480
161neuronal stem cell maintenance (GO:0097150)2.51830563
162DNA methylation involved in gamete generation (GO:0043046)2.51164703
163kidney morphogenesis (GO:0060993)2.50877672
164multicellular organism reproduction (GO:0032504)2.50368148
165positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50305991
166eye photoreceptor cell development (GO:0042462)2.49179615
167binding of sperm to zona pellucida (GO:0007339)2.48908868
168positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.48613462
169regulation of mesenchymal cell apoptotic process (GO:2001053)2.48340836
170synaptic vesicle maturation (GO:0016188)2.48079808
171fear response (GO:0042596)2.47722566
172innervation (GO:0060384)2.47479698
173regulation of neurotransmitter secretion (GO:0046928)2.47297065
174signal peptide processing (GO:0006465)2.47216091
175forebrain neuron differentiation (GO:0021879)2.45288778
176ncRNA catabolic process (GO:0034661)2.44997681
177sulfation (GO:0051923)2.44204296
178rhodopsin mediated signaling pathway (GO:0016056)2.40971965
179axon ensheathment in central nervous system (GO:0032291)2.40905854
180central nervous system myelination (GO:0022010)2.40905854
181protein polyglutamylation (GO:0018095)2.39821344
182detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38974549
183recombinational repair (GO:0000725)2.38965428
184serotonin metabolic process (GO:0042428)2.38673102
185epithelial tube formation (GO:0072175)2.38656360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46858395
2GBX2_23144817_ChIP-Seq_PC3_Human3.82030796
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63278094
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51522083
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39068010
6TAF15_26573619_Chip-Seq_HEK293_Human2.30270500
7ZNF274_21170338_ChIP-Seq_K562_Hela2.29711168
8REST_21632747_ChIP-Seq_MESCs_Mouse2.29598419
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28182956
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27766188
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26969886
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21435207
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.07434137
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.06986477
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06306631
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05166427
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.02185950
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02143864
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00087829
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97485681
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96162352
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95392497
23FUS_26573619_Chip-Seq_HEK293_Human1.95004196
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90993279
25IGF1R_20145208_ChIP-Seq_DFB_Human1.87659270
26VDR_22108803_ChIP-Seq_LS180_Human1.86715008
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86275536
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83058499
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81935236
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79782854
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.77355834
32* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76687786
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76177869
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74689105
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73600420
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.72921183
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71860842
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68704987
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68129687
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68129687
41P300_19829295_ChIP-Seq_ESCs_Human1.66565954
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.66524372
43SMAD4_21799915_ChIP-Seq_A2780_Human1.63953759
44* RNF2_27304074_Chip-Seq_NSC_Mouse1.63463503
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61632772
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60707550
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.58873505
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58461609
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.56376215
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.55462195
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55370045
52BCAT_22108803_ChIP-Seq_LS180_Human1.51167266
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48982932
54IRF1_19129219_ChIP-ChIP_H3396_Human1.47841941
55MYC_18940864_ChIP-ChIP_HL60_Human1.47269216
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47031438
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.45233422
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44886004
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44556559
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44327070
61TP53_22573176_ChIP-Seq_HFKS_Human1.40143755
62* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36036652
63ER_23166858_ChIP-Seq_MCF-7_Human1.34861407
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33704573
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33296359
66TCF4_22108803_ChIP-Seq_LS180_Human1.32754690
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31674847
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.31618416
69AR_21572438_ChIP-Seq_LNCaP_Human1.30011815
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29253303
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.28553677
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26061870
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.25628577
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25384508
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25249791
76DROSHA_22980978_ChIP-Seq_HELA_Human1.22752047
77NANOG_19829295_ChIP-Seq_ESCs_Human1.22410609
78SOX2_19829295_ChIP-Seq_ESCs_Human1.22410609
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21436403
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19882130
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.19675202
82SOX9_26525672_Chip-Seq_HEART_Mouse1.19145438
83EWS_26573619_Chip-Seq_HEK293_Human1.18929120
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18830734
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18495766
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17825643
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.17825643
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17290239
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16231144
90* JUN_21703547_ChIP-Seq_K562_Human1.15373821
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.15279883
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15274321
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14947391
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14688938
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13343978
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.12847003
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12703332
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12015011
99* AR_25329375_ChIP-Seq_VCAP_Human1.11958385
100P53_22387025_ChIP-Seq_ESCs_Mouse1.11867454
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11749483
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.09784609
103STAT3_23295773_ChIP-Seq_U87_Human1.09369194
104* TCF4_23295773_ChIP-Seq_U87_Human1.09309569
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06859557
106ELK1_19687146_ChIP-ChIP_HELA_Human1.06605522
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.06559337
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05665231
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.05350315
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04274342
111CBP_20019798_ChIP-Seq_JUKART_Human1.04274342
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04041729
113CDX2_22108803_ChIP-Seq_LS180_Human1.03807388
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03602970
115* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03055793
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02400216
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01822708
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01696176
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01624873
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01624873
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.01512172
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01155412
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.00992589
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00976141
125TP53_16413492_ChIP-PET_HCT116_Human1.00302823
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.00060439
127* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99903212
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99253539
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97319510
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97226744
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.97124387
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96938221
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95493517
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95429920
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93368932
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.93255063
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93149399
138KDM2B_26808549_Chip-Seq_REH_Human0.92852136
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91231097
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.90855783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.23722936
2MP0004859_abnormal_synaptic_plasticity4.00068416
3MP0003635_abnormal_synaptic_transmissio3.02521794
4MP0005410_abnormal_fertilization2.76293932
5MP0008877_abnormal_DNA_methylation2.69850817
6MP0001188_hyperpigmentation2.69630727
7MP0001968_abnormal_touch/_nociception2.59967167
8MP0000569_abnormal_digit_pigmentation2.53870770
9MP0009745_abnormal_behavioral_response2.49925764
10MP0009046_muscle_twitch2.44620468
11MP0002063_abnormal_learning/memory/cond2.43532208
12MP0002736_abnormal_nociception_after2.36927590
13MP0002064_seizures2.31902279
14MP0002572_abnormal_emotion/affect_behav2.28011223
15MP0001984_abnormal_olfaction2.24969112
16MP0003195_calcinosis2.19908258
17MP0004270_analgesia2.14676921
18MP0006276_abnormal_autonomic_nervous2.08071107
19MP0003122_maternal_imprinting2.04542593
20MP0002272_abnormal_nervous_system1.99502360
21MP0002735_abnormal_chemical_nociception1.97587821
22MP0002734_abnormal_mechanical_nocicepti1.93707608
23MP0001486_abnormal_startle_reflex1.79366683
24MP0003787_abnormal_imprinting1.77431873
25MP0002938_white_spotting1.76920197
26MP0001501_abnormal_sleep_pattern1.74770882
27MP0002557_abnormal_social/conspecific_i1.72829191
28MP0005646_abnormal_pituitary_gland1.72721727
29MP0002184_abnormal_innervation1.72530832
30MP0003646_muscle_fatigue1.70564699
31MP0009780_abnormal_chondrocyte_physiolo1.70367733
32MP0005423_abnormal_somatic_nervous1.66486300
33MP0001440_abnormal_grooming_behavior1.65626442
34MP0002067_abnormal_sensory_capabilities1.65200447
35MP0006072_abnormal_retinal_apoptosis1.64914297
36MP0006292_abnormal_olfactory_placode1.64096123
37MP0008058_abnormal_DNA_repair1.63938975
38MP0000778_abnormal_nervous_system1.61592847
39MP0003698_abnormal_male_reproductive1.61289643
40MP0000427_abnormal_hair_cycle1.58144398
41MP0005645_abnormal_hypothalamus_physiol1.52254173
42MP0004142_abnormal_muscle_tone1.52223783
43MP0008872_abnormal_physiological_respon1.49245068
44MP0002733_abnormal_thermal_nociception1.46764958
45MP0005187_abnormal_penis_morphology1.46655080
46MP0010386_abnormal_urinary_bladder1.45265800
47MP0005551_abnormal_eye_electrophysiolog1.43952080
48MP0001529_abnormal_vocalization1.43619844
49MP0000631_abnormal_neuroendocrine_gland1.42602899
50MP0002909_abnormal_adrenal_gland1.38379727
51MP0003718_maternal_effect1.37521765
52MP0001970_abnormal_pain_threshold1.37198066
53MP0001502_abnormal_circadian_rhythm1.36518864
54MP0002928_abnormal_bile_duct1.36509633
55MP0002102_abnormal_ear_morphology1.35572209
56MP0003121_genomic_imprinting1.34867038
57MP0005174_abnormal_tail_pigmentation1.33291627
58MP0002638_abnormal_pupillary_reflex1.30636310
59MP0002882_abnormal_neuron_morphology1.30363433
60MP0005623_abnormal_meninges_morphology1.30163868
61MP0000955_abnormal_spinal_cord1.28839220
62MP0004043_abnormal_pH_regulation1.28702559
63MP0000372_irregular_coat_pigmentation1.28675412
64MP0004147_increased_porphyrin_level1.27834972
65MP0001929_abnormal_gametogenesis1.27620208
66MP0005084_abnormal_gallbladder_morpholo1.27091947
67MP0004811_abnormal_neuron_physiology1.25873284
68MP0005195_abnormal_posterior_eye1.25662115
69MP0002822_catalepsy1.24383964
70MP0002160_abnormal_reproductive_system1.22933859
71MP0000013_abnormal_adipose_tissue1.22565664
72MP0004233_abnormal_muscle_weight1.22560852
73MP0003283_abnormal_digestive_organ1.22088203
74MP0000383_abnormal_hair_follicle1.18585602
75MP0001293_anophthalmia1.18413977
76MP0005389_reproductive_system_phenotype1.17498462
77MP0005386_behavior/neurological_phenoty1.16226869
78MP0004924_abnormal_behavior1.16226869
79MP0008995_early_reproductive_senescence1.14435034
80MP0003879_abnormal_hair_cell1.12410841
81MP0002152_abnormal_brain_morphology1.11224749
82MP0003123_paternal_imprinting1.10610937
83MP0008875_abnormal_xenobiotic_pharmacok1.08604965
84MP0002066_abnormal_motor_capabilities/c1.07428643
85MP0003937_abnormal_limbs/digits/tail_de1.05372373
86MP0005391_vision/eye_phenotype1.05253487
87MP0002138_abnormal_hepatobiliary_system1.04665811
88MP0004133_heterotaxia1.04184246
89MP0005253_abnormal_eye_physiology1.03147982
90MP0002210_abnormal_sex_determination1.02902952
91MP0003890_abnormal_embryonic-extraembry1.02854526
92MP0001905_abnormal_dopamine_level1.01981118
93MP0005075_abnormal_melanosome_morpholog1.01721073
94MP0008569_lethality_at_weaning1.01289286
95MP0002234_abnormal_pharynx_morphology1.00296941
96MP0004145_abnormal_muscle_electrophysio1.00153835
97MP0002876_abnormal_thyroid_physiology0.99491651
98MP0002653_abnormal_ependyma_morphology0.98933234
99MP0002752_abnormal_somatic_nervous0.98807259
100MP0001324_abnormal_eye_pigmentation0.97396125
101MP0002095_abnormal_skin_pigmentation0.97335565
102MP0005377_hearing/vestibular/ear_phenot0.97072159
103MP0003878_abnormal_ear_physiology0.97072159
104MP0001919_abnormal_reproductive_system0.96893675
105MP0000049_abnormal_middle_ear0.96446340
106MP0002751_abnormal_autonomic_nervous0.96429212
107MP0002277_abnormal_respiratory_mucosa0.94349829
108MP0008057_abnormal_DNA_replication0.93874532
109MP0002837_dystrophic_cardiac_calcinosis0.90491598
110MP0005499_abnormal_olfactory_system0.90242437
111MP0005394_taste/olfaction_phenotype0.90242437
112MP0010094_abnormal_chromosome_stability0.90036326
113MP0002282_abnormal_trachea_morphology0.87274919
114MP0001145_abnormal_male_reproductive0.87148847
115MP0000026_abnormal_inner_ear0.87038358
116MP0001963_abnormal_hearing_physiology0.86964524
117MP0003119_abnormal_digestive_system0.86290167
118MP0004742_abnormal_vestibular_system0.85349570
119MP0005379_endocrine/exocrine_gland_phen0.85242475
120MP0003861_abnormal_nervous_system0.84851185
121MP0002161_abnormal_fertility/fecundity0.83554505
122MP0000678_abnormal_parathyroid_gland0.82608373
123MP0002233_abnormal_nose_morphology0.81301820
124MP0008789_abnormal_olfactory_epithelium0.80554657
125MP0003942_abnormal_urinary_system0.78846607
126MP0002229_neurodegeneration0.77537955
127MP0003183_abnormal_peptide_metabolism0.77483140
128MP0001986_abnormal_taste_sensitivity0.74246715
129MP0005171_absent_coat_pigmentation0.74225119
130MP0000653_abnormal_sex_gland0.73876905
131MP0004858_abnormal_nervous_system0.73739487
132MP0000681_abnormal_thyroid_gland0.73432313
133MP0001485_abnormal_pinna_reflex0.71757126
134MP0003136_yellow_coat_color0.70859858
135MP0002069_abnormal_eating/drinking_beha0.70691737
136MP0004215_abnormal_myocardial_fiber0.69340132
137MP0004885_abnormal_endolymph0.68746017

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.08265432
2Absent/shortened dynein arms (HP:0200106)6.08265432
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.70493115
4Abnormal respiratory motile cilium physiology (HP:0012261)5.25974428
5Abnormal ciliary motility (HP:0012262)5.25957526
6Abnormal respiratory epithelium morphology (HP:0012253)5.03606605
7Abnormal respiratory motile cilium morphology (HP:0005938)5.03606605
8Focal motor seizures (HP:0011153)4.78610789
9Rhinitis (HP:0012384)4.19693983
10Gait imbalance (HP:0002141)3.95599951
11Medial flaring of the eyebrow (HP:0010747)3.94129170
12Epileptic encephalopathy (HP:0200134)3.88726154
13Congenital primary aphakia (HP:0007707)3.83372944
14Nephrogenic diabetes insipidus (HP:0009806)3.45504513
15Chronic bronchitis (HP:0004469)3.30256820
16Atonic seizures (HP:0010819)3.16309138
17Nephronophthisis (HP:0000090)3.06363660
18Abnormality of the renal cortex (HP:0011035)3.06199213
19Hyperventilation (HP:0002883)3.02729263
20Congenital stationary night blindness (HP:0007642)2.99981190
21Tubular atrophy (HP:0000092)2.96890972
22Focal seizures (HP:0007359)2.93544236
23Chronic hepatic failure (HP:0100626)2.92240796
24Vaginal atresia (HP:0000148)2.87238375
25Febrile seizures (HP:0002373)2.84909569
26Genital tract atresia (HP:0001827)2.83803589
27Abnormality of midbrain morphology (HP:0002418)2.80868870
28Molar tooth sign on MRI (HP:0002419)2.80868870
29Visual hallucinations (HP:0002367)2.72576843
30Progressive cerebellar ataxia (HP:0002073)2.70530589
31Poor coordination (HP:0002370)2.70480022
32Pancreatic fibrosis (HP:0100732)2.69119796
33Retinal dysplasia (HP:0007973)2.60668985
34Myokymia (HP:0002411)2.60163113
35Absence seizures (HP:0002121)2.55406100
36Aplasia/Hypoplasia of the lens (HP:0008063)2.51082039
37Anencephaly (HP:0002323)2.46683573
38Abolished electroretinogram (ERG) (HP:0000550)2.46195411
39Cerebellar dysplasia (HP:0007033)2.45736716
40Male pseudohermaphroditism (HP:0000037)2.40725286
41Hypoplastic iliac wings (HP:0002866)2.34505692
42Abnormal drinking behavior (HP:0030082)2.34183345
43Polydipsia (HP:0001959)2.34183345
44True hermaphroditism (HP:0010459)2.33871339
45Genetic anticipation (HP:0003743)2.33740712
46Infertility (HP:0000789)2.33729507
47Intestinal atresia (HP:0011100)2.33220020
48Optic nerve hypoplasia (HP:0000609)2.29792983
49Severe visual impairment (HP:0001141)2.28359174
50Abnormal rod and cone electroretinograms (HP:0008323)2.28034842
51Acute necrotizing encephalopathy (HP:0006965)2.27398358
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27267006
53Furrowed tongue (HP:0000221)2.27082819
54Abnormality of the renal medulla (HP:0100957)2.26528200
55Amblyopia (HP:0000646)2.26065955
56Specific learning disability (HP:0001328)2.24026705
57Pendular nystagmus (HP:0012043)2.21358265
58Dialeptic seizures (HP:0011146)2.21203415
59Progressive inability to walk (HP:0002505)2.20359793
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17380115
61Volvulus (HP:0002580)2.14922763
62Keratoconus (HP:0000563)2.13784584
63Increased corneal curvature (HP:0100692)2.13784584
64Renal cortical cysts (HP:0000803)2.12840077
65Postaxial hand polydactyly (HP:0001162)2.09747154
66Epileptiform EEG discharges (HP:0011182)2.09689331
67Abnormal mitochondria in muscle tissue (HP:0008316)2.08801643
68Pancreatic cysts (HP:0001737)2.08346101
69Facial cleft (HP:0002006)2.06771444
70Oligodactyly (hands) (HP:0001180)2.05227480
71Bifid tongue (HP:0010297)2.05145873
72Decreased central vision (HP:0007663)2.04803930
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.03410326
74Generalized tonic-clonic seizures (HP:0002069)2.01922804
75Broad-based gait (HP:0002136)2.01018914
76Abnormality of the labia minora (HP:0012880)2.00440710
77Gaze-evoked nystagmus (HP:0000640)1.97769188
78Large for gestational age (HP:0001520)1.97737098
79Supernumerary spleens (HP:0009799)1.96829833
80Progressive macrocephaly (HP:0004481)1.95972933
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.94524295
82Bronchiectasis (HP:0002110)1.94268748
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.92724523
84EEG with generalized epileptiform discharges (HP:0011198)1.92693062
85Constricted visual fields (HP:0001133)1.90573619
86Median cleft lip (HP:0000161)1.90386078
87Tubulointerstitial nephritis (HP:0001970)1.90175148
88Tubulointerstitial abnormality (HP:0001969)1.88852712
89Menstrual irregularities (HP:0000858)1.88354278
90Abnormal biliary tract physiology (HP:0012439)1.88277571
91Bile duct proliferation (HP:0001408)1.88277571
92Lissencephaly (HP:0001339)1.88133261
93Type II lissencephaly (HP:0007260)1.85618918
94Abnormality of alanine metabolism (HP:0010916)1.85574480
95Hyperalaninemia (HP:0003348)1.85574480
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85574480
97Sloping forehead (HP:0000340)1.83774183
98Broad foot (HP:0001769)1.83537919
99Colon cancer (HP:0003003)1.80864198
100Optic disc pallor (HP:0000543)1.80590134
101Aganglionic megacolon (HP:0002251)1.80188525
102Dandy-Walker malformation (HP:0001305)1.79661784
103Thyroid-stimulating hormone excess (HP:0002925)1.79030863
104Septo-optic dysplasia (HP:0100842)1.78883882
105Postaxial foot polydactyly (HP:0001830)1.78691099
106Preaxial hand polydactyly (HP:0001177)1.78319728
107Bony spicule pigmentary retinopathy (HP:0007737)1.77697940
108Severe muscular hypotonia (HP:0006829)1.77340039
109Gastrointestinal atresia (HP:0002589)1.77221961
110Impaired smooth pursuit (HP:0007772)1.77065160
111Decreased circulating renin level (HP:0003351)1.76642525
112Abnormality of the pons (HP:0007361)1.76607369
113Hypsarrhythmia (HP:0002521)1.76351992
114Asplenia (HP:0001746)1.76080124
115Polyuria (HP:0000103)1.75499544
116Abnormality of the ileum (HP:0001549)1.75403980
117Abnormal hair whorl (HP:0010721)1.72964408
118Absent speech (HP:0001344)1.72366080
119Protruding tongue (HP:0010808)1.72287700
120Bilateral microphthalmos (HP:0007633)1.72024704
121Oculomotor apraxia (HP:0000657)1.71839843
122Decreased testicular size (HP:0008734)1.71506451
123Fibular hypoplasia (HP:0003038)1.70478266
124Poor suck (HP:0002033)1.69807159
125Hypoplasia of the pons (HP:0012110)1.69194697
126Congenital hepatic fibrosis (HP:0002612)1.68409918
127Narrow forehead (HP:0000341)1.68271771
128Anxiety (HP:0000739)1.66195171
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.64708999
130Absent eyebrow (HP:0002223)1.63922941
131Agitation (HP:0000713)1.63757655
132Drooling (HP:0002307)1.62331401
133Excessive salivation (HP:0003781)1.62331401
134Mitochondrial inheritance (HP:0001427)1.62125397
135Retinitis pigmentosa (HP:0000510)1.59221301
136Abnormality of ocular smooth pursuit (HP:0000617)1.58925781
137Sclerocornea (HP:0000647)1.57576560
138Astigmatism (HP:0000483)1.56684720
139Dental crowding (HP:0000678)1.55841187
140Depression (HP:0000716)1.55436572
141Pheochromocytoma (HP:0002666)1.55067736
142Inability to walk (HP:0002540)1.54890503
143Truncal ataxia (HP:0002078)1.54492032
144Attenuation of retinal blood vessels (HP:0007843)1.53237466
145Cystic liver disease (HP:0006706)1.51347575
146Shoulder girdle muscle weakness (HP:0003547)1.51027255
147Occipital encephalocele (HP:0002085)1.50311570
148Hemiparesis (HP:0001269)1.49873464
149Limb dystonia (HP:0002451)1.49813677
150Abnormality of dentin (HP:0010299)1.49319653
151Anophthalmia (HP:0000528)1.48979200
152Left ventricular hypertrophy (HP:0001712)1.48895796
153Short foot (HP:0001773)1.48307859
154Unsteady gait (HP:0002317)1.48270755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.39939027
2CASK4.44996349
3CDK193.44965305
4NTRK33.38371844
5EPHA43.17090288
6MAPK152.72256989
7PDK32.66620674
8PDK42.66620674
9MAP2K72.58367299
10MAP3K42.56740412
11PNCK2.50455694
12PRPF4B2.42992790
13ZAK2.34494440
14NUAK12.30636438
15MARK12.17542410
16MINK12.14593518
17MAP4K22.07413561
18GRK11.99674189
19INSRR1.89541608
20TNIK1.88152769
21NME11.88068278
22PRKD31.82903316
23STK161.75838676
24PLK21.74412570
25TAOK31.72736225
26BRSK21.71560575
27WNK41.60575413
28MAP3K121.59389182
29MKNK21.44598153
30MAPK131.44561146
31CAMKK21.42173513
32AKT31.41743122
33TESK11.41445691
34STK391.41005448
35TLK11.38303065
36BRAF1.36590940
37DAPK11.34469292
38PRKCG1.25989769
39CDC71.25928381
40PDK21.25790796
41TIE11.19584840
42KSR11.16037027
43WNK31.15444625
44NTRK21.14266396
45MAP2K41.14209573
46CDK31.12984821
47CCNB11.12225363
48SIK31.09557755
49MAPKAPK51.08221041
50TGFBR11.05279624
51PTK2B1.02037851
52DYRK30.97881039
53UHMK10.96921793
54CDK50.96098575
55VRK10.95630348
56CAMK2A0.94073076
57MAP3K90.92617587
58CDK140.91377748
59BMPR1B0.90322955
60CDK180.88385373
61TRPM70.87992911
62FGFR20.85644229
63STK30.85255382
64PASK0.84514309
65CDK11A0.82744117
66BCR0.81321511
67ERBB30.81251723
68CAMK2B0.79805014
69STK38L0.79562151
70PLK30.79324403
71CDK150.79195222
72PAK60.79070310
73CDK80.79043837
74BUB10.78878754
75PLK40.78847967
76GRK50.77263211
77TEC0.77026758
78TXK0.73562946
79DAPK20.72325938
80CSNK1G10.70717679
81BMPR20.70495780
82MAPKAPK30.70427152
83CAMKK10.68163873
84FER0.66214583
85DYRK1A0.65292954
86NLK0.64414672
87NEK20.61587622
88TRIM280.60414900
89FES0.58465457
90STK110.58378156
91PHKG10.57224905
92PHKG20.57224905
93YES10.57041913
94KIT0.56502506
95STK380.55510576
96PIK3CA0.54498007
97PLK10.54095627
98PRKCE0.53933895
99AURKA0.53827497
100ADRBK10.53259859
101ACVR1B0.52963769
102PINK10.52200127
103NTRK10.52146975
104MKNK10.51975795
105TAF10.51212631
106MUSK0.49879639
107CSNK1G30.49788298
108RPS6KA50.49618697
109ATR0.47977753
110FLT30.47208513
111TTK0.46541317
112TSSK60.46532502
113MST40.45808975
114DYRK20.45254662
115CSNK1A1L0.45111004
116CHEK20.44735589
117ATM0.43554453
118SGK2230.43523576
119SGK4940.43523576
120ADRBK20.43131005
121ARAF0.42969790
122PKN10.42322612
123SRPK10.42040376
124OXSR10.42038728
125SGK20.41746216
126CAMK2D0.41414234
127MAP3K60.41177794
128WEE10.41091339
129PRKCQ0.40679098
130LIMK10.40646724
131CSNK1G20.40303402
132MAPK100.37916548
133VRK20.37810014
134ERBB20.37768812
135CAMK10.37592028
136CSNK1D0.36487697
137STK240.35724735
138NEK60.35239690
139OBSCN0.35231510
140CAMK1G0.33161437
141PRKAA10.32722858
142PRKG10.32512746
143EIF2AK20.32184580
144PRKACA0.31904095
145PAK30.31630486
146RIPK40.31167528
147SIK20.29976661
148GRK70.29626430
149RPS6KB10.29083772

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93604246
2Synaptic vesicle cycle_Homo sapiens_hsa047213.08402567
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87186575
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57913950
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.57861216
6Butanoate metabolism_Homo sapiens_hsa006502.49321286
7Amphetamine addiction_Homo sapiens_hsa050312.48679741
8Circadian entrainment_Homo sapiens_hsa047132.44338320
9Olfactory transduction_Homo sapiens_hsa047402.42322194
10Long-term potentiation_Homo sapiens_hsa047202.40135101
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37345318
12Morphine addiction_Homo sapiens_hsa050322.36950150
13Linoleic acid metabolism_Homo sapiens_hsa005912.35338960
14GABAergic synapse_Homo sapiens_hsa047272.32798323
15Oxidative phosphorylation_Homo sapiens_hsa001902.22664876
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21292758
17Glutamatergic synapse_Homo sapiens_hsa047242.13247759
18Collecting duct acid secretion_Homo sapiens_hsa049662.13008427
19Phototransduction_Homo sapiens_hsa047442.11842613
20Selenocompound metabolism_Homo sapiens_hsa004502.11666167
21Taste transduction_Homo sapiens_hsa047422.11581728
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10441683
23Dopaminergic synapse_Homo sapiens_hsa047282.10050584
24Nitrogen metabolism_Homo sapiens_hsa009102.08860118
25Insulin secretion_Homo sapiens_hsa049111.98972893
26Huntingtons disease_Homo sapiens_hsa050161.90365994
27Ether lipid metabolism_Homo sapiens_hsa005651.82725935
28Parkinsons disease_Homo sapiens_hsa050121.77476820
29Serotonergic synapse_Homo sapiens_hsa047261.76394146
30Vibrio cholerae infection_Homo sapiens_hsa051101.64058738
31Alzheimers disease_Homo sapiens_hsa050101.62015204
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60998852
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59997858
34Cardiac muscle contraction_Homo sapiens_hsa042601.57558548
35Caffeine metabolism_Homo sapiens_hsa002321.56753598
36Cocaine addiction_Homo sapiens_hsa050301.54251841
37Salivary secretion_Homo sapiens_hsa049701.49140047
38Tryptophan metabolism_Homo sapiens_hsa003801.47026720
39Long-term depression_Homo sapiens_hsa047301.45788443
40Cholinergic synapse_Homo sapiens_hsa047251.44974108
41Renin secretion_Homo sapiens_hsa049241.42856684
42Protein export_Homo sapiens_hsa030601.39437933
43Calcium signaling pathway_Homo sapiens_hsa040201.39322255
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34323254
45Oocyte meiosis_Homo sapiens_hsa041141.33792511
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33553181
47One carbon pool by folate_Homo sapiens_hsa006701.29019122
48ABC transporters_Homo sapiens_hsa020101.23704280
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22980383
50Non-homologous end-joining_Homo sapiens_hsa034501.22813852
51Propanoate metabolism_Homo sapiens_hsa006401.22730705
52Alcoholism_Homo sapiens_hsa050341.22178219
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19040633
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18580304
55Oxytocin signaling pathway_Homo sapiens_hsa049211.17108229
56Peroxisome_Homo sapiens_hsa041461.10960468
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.06727133
58Gastric acid secretion_Homo sapiens_hsa049711.06478748
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04802829
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97623307
61Melanogenesis_Homo sapiens_hsa049160.96725501
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95244098
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92836653
64Glucagon signaling pathway_Homo sapiens_hsa049220.92263496
65cAMP signaling pathway_Homo sapiens_hsa040240.92213729
66Ovarian steroidogenesis_Homo sapiens_hsa049130.91822939
67Hedgehog signaling pathway_Homo sapiens_hsa043400.91274222
68Chemical carcinogenesis_Homo sapiens_hsa052040.91159654
69Purine metabolism_Homo sapiens_hsa002300.90911636
70Estrogen signaling pathway_Homo sapiens_hsa049150.90005518
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89817649
72Axon guidance_Homo sapiens_hsa043600.89208449
73Gap junction_Homo sapiens_hsa045400.88705705
74Basal transcription factors_Homo sapiens_hsa030220.88574614
75Regulation of autophagy_Homo sapiens_hsa041400.87771130
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.87564650
77Fanconi anemia pathway_Homo sapiens_hsa034600.86061750
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85870261
79RNA polymerase_Homo sapiens_hsa030200.84616232
80Nucleotide excision repair_Homo sapiens_hsa034200.84315194
81Mismatch repair_Homo sapiens_hsa034300.84299213
82Dorso-ventral axis formation_Homo sapiens_hsa043200.83705529
83Retinol metabolism_Homo sapiens_hsa008300.82887689
84Homologous recombination_Homo sapiens_hsa034400.82871747
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79434031
86Arachidonic acid metabolism_Homo sapiens_hsa005900.78792940
87Wnt signaling pathway_Homo sapiens_hsa043100.77531546
88DNA replication_Homo sapiens_hsa030300.73406200
89Circadian rhythm_Homo sapiens_hsa047100.73109247
90GnRH signaling pathway_Homo sapiens_hsa049120.69440038
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68808067
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68725912
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67636570
94Pyrimidine metabolism_Homo sapiens_hsa002400.66383081
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66157974
96beta-Alanine metabolism_Homo sapiens_hsa004100.65909100
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65083952
98N-Glycan biosynthesis_Homo sapiens_hsa005100.63946340
99RNA transport_Homo sapiens_hsa030130.63554952
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.63292183
101Glycerolipid metabolism_Homo sapiens_hsa005610.62336327
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62264217
103Glioma_Homo sapiens_hsa052140.60652417
104mRNA surveillance pathway_Homo sapiens_hsa030150.60505599
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60165660
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59737666
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55597501
108Thyroid hormone synthesis_Homo sapiens_hsa049180.53993111
109Spliceosome_Homo sapiens_hsa030400.53910500
110Type II diabetes mellitus_Homo sapiens_hsa049300.52871305
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52753740
112ErbB signaling pathway_Homo sapiens_hsa040120.52752095
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.52353620
114Metabolic pathways_Homo sapiens_hsa011000.52185078
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51701207
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.51639661
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51377847
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50807084
119Ribosome_Homo sapiens_hsa030100.50534629
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50441282
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49349043
122Cell cycle_Homo sapiens_hsa041100.47545918
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46783951
124MAPK signaling pathway_Homo sapiens_hsa040100.46466825
125Melanoma_Homo sapiens_hsa052180.45849757
126Basal cell carcinoma_Homo sapiens_hsa052170.45741304
127Mineral absorption_Homo sapiens_hsa049780.45677287
128Fatty acid biosynthesis_Homo sapiens_hsa000610.45236149
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44613366
130Pyruvate metabolism_Homo sapiens_hsa006200.43581949
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43581535
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43095876
133Ras signaling pathway_Homo sapiens_hsa040140.43032279
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41456561
135Base excision repair_Homo sapiens_hsa034100.41110651
136Pancreatic secretion_Homo sapiens_hsa049720.39949205
137Type I diabetes mellitus_Homo sapiens_hsa049400.39823395
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.38156046
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37664601
140RNA degradation_Homo sapiens_hsa030180.35329758
141Inositol phosphate metabolism_Homo sapiens_hsa005620.33969608
142Proteasome_Homo sapiens_hsa030500.33054744
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32987296
144Sphingolipid metabolism_Homo sapiens_hsa006000.32797957
145TGF-beta signaling pathway_Homo sapiens_hsa043500.32534213
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32072778
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31056499
148Systemic lupus erythematosus_Homo sapiens_hsa053220.30546983
149Lysine degradation_Homo sapiens_hsa003100.30404042
150Rheumatoid arthritis_Homo sapiens_hsa053230.30297943
151Histidine metabolism_Homo sapiens_hsa003400.30219995
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28593994

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