IQGAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.66070046
2L-phenylalanine catabolic process (GO:0006559)6.66070046
3L-phenylalanine metabolic process (GO:0006558)6.35551866
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.35551866
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.30461689
6aromatic amino acid family catabolic process (GO:0009074)6.25807841
7tryptophan catabolic process (GO:0006569)5.88758286
8indole-containing compound catabolic process (GO:0042436)5.88758286
9indolalkylamine catabolic process (GO:0046218)5.88758286
10positive regulation of gamma-delta T cell activation (GO:0046645)5.82622842
11kynurenine metabolic process (GO:0070189)5.73425490
12urea metabolic process (GO:0019627)5.69099391
13urea cycle (GO:0000050)5.69099391
14bile acid biosynthetic process (GO:0006699)5.56601774
15tryptophan metabolic process (GO:0006568)5.54499194
16high-density lipoprotein particle remodeling (GO:0034375)5.51984506
17alpha-linolenic acid metabolic process (GO:0036109)5.36755389
18sulfur amino acid catabolic process (GO:0000098)5.32857156
19nitrogen cycle metabolic process (GO:0071941)5.18315016
20glyoxylate metabolic process (GO:0046487)5.16511737
21complement activation, alternative pathway (GO:0006957)5.12426573
22cysteine metabolic process (GO:0006534)5.10346227
23bile acid and bile salt transport (GO:0015721)5.06671677
24regulation of protein activation cascade (GO:2000257)5.05533998
25negative regulation of fibrinolysis (GO:0051918)5.03768391
26regulation of triglyceride catabolic process (GO:0010896)5.02308225
27bile acid metabolic process (GO:0008206)4.94379837
28regulation of cholesterol esterification (GO:0010872)4.93636315
29peptidyl-glutamic acid carboxylation (GO:0017187)4.92443884
30protein carboxylation (GO:0018214)4.92443884
31reverse cholesterol transport (GO:0043691)4.90465066
32regulation of fibrinolysis (GO:0051917)4.88306046
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87801449
34phospholipid efflux (GO:0033700)4.84404867
35protein-lipid complex remodeling (GO:0034368)4.83212648
36macromolecular complex remodeling (GO:0034367)4.83212648
37plasma lipoprotein particle remodeling (GO:0034369)4.83212648
38homocysteine metabolic process (GO:0050667)4.77916441
39negative regulation of cholesterol transport (GO:0032375)4.75966420
40negative regulation of sterol transport (GO:0032372)4.75966420
41regulation of complement activation (GO:0030449)4.71639733
42serine family amino acid catabolic process (GO:0009071)4.64891444
43amino-acid betaine metabolic process (GO:0006577)4.52580491
44aromatic amino acid family metabolic process (GO:0009072)4.47204253
45intestinal cholesterol absorption (GO:0030299)4.42762311
46regulation of B cell receptor signaling pathway (GO:0050855)4.41678613
47cholesterol efflux (GO:0033344)4.40423102
48plasma lipoprotein particle assembly (GO:0034377)4.40176784
49acylglycerol homeostasis (GO:0055090)4.39609645
50triglyceride homeostasis (GO:0070328)4.39609645
51cellular glucuronidation (GO:0052695)4.37774385
52regulation of gamma-delta T cell differentiation (GO:0045586)4.33249197
53lysine metabolic process (GO:0006553)4.30918509
54lysine catabolic process (GO:0006554)4.30918509
55neutrophil activation involved in immune response (GO:0002283)4.30830521
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25605562
57regulation of gamma-delta T cell activation (GO:0046643)4.25098312
58drug catabolic process (GO:0042737)4.23163227
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22781329
60positive regulation of B cell differentiation (GO:0045579)4.22586037
61tyrosine metabolic process (GO:0006570)4.20633568
62alpha-amino acid catabolic process (GO:1901606)4.20518012
63indolalkylamine metabolic process (GO:0006586)4.13569741
64plasma lipoprotein particle clearance (GO:0034381)4.12231866
65benzene-containing compound metabolic process (GO:0042537)4.05023517
66cellular biogenic amine catabolic process (GO:0042402)4.04321931
67amine catabolic process (GO:0009310)4.04321931
68imidazole-containing compound metabolic process (GO:0052803)4.03622521
69glycine metabolic process (GO:0006544)4.03276468
70low-density lipoprotein particle remodeling (GO:0034374)4.02328803
71very-low-density lipoprotein particle assembly (GO:0034379)4.01919679
72phospholipid homeostasis (GO:0055091)3.95866776
73flavonoid metabolic process (GO:0009812)3.94697288
74protein-lipid complex assembly (GO:0065005)3.94461549
75cholesterol homeostasis (GO:0042632)3.93958233
76ethanol oxidation (GO:0006069)3.92908922
77positive regulation of triglyceride lipase activity (GO:0061365)3.92659823
78positive regulation of lipoprotein lipase activity (GO:0051006)3.92659823
79regulation of bile acid biosynthetic process (GO:0070857)3.89641597
80cellular amino acid catabolic process (GO:0009063)3.88452789
81cellular ketone body metabolic process (GO:0046950)3.88233548
82sterol homeostasis (GO:0055092)3.88160071
83glutamate metabolic process (GO:0006536)3.84313022
84serine family amino acid metabolic process (GO:0009069)3.83581651
85plasma lipoprotein particle organization (GO:0071827)3.82412641
86glucuronate metabolic process (GO:0019585)3.81301072
87uronic acid metabolic process (GO:0006063)3.81301072
88dicarboxylic acid biosynthetic process (GO:0043650)3.80817004
89cellular modified amino acid catabolic process (GO:0042219)3.77431067
90positive regulation of lipid catabolic process (GO:0050996)3.76123076
91serine family amino acid biosynthetic process (GO:0009070)3.75559442
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75087789
93negative regulation of cell killing (GO:0031342)3.75087789
94blood coagulation, intrinsic pathway (GO:0007597)3.73262941
95lipoprotein metabolic process (GO:0042157)3.72974998
96coenzyme catabolic process (GO:0009109)3.72906927
97fibrinolysis (GO:0042730)3.71044386
98arginine metabolic process (GO:0006525)3.70371426
99regulation of cholesterol homeostasis (GO:2000188)3.67937228
100negative regulation of lipase activity (GO:0060192)3.64034753
101drug transmembrane transport (GO:0006855)3.62479185
102protein-lipid complex subunit organization (GO:0071825)3.59595030
103response to peptidoglycan (GO:0032494)3.57463818
104response to nitrosative stress (GO:0051409)3.55541811
105negative regulation of interleukin-12 production (GO:0032695)3.55480544
106protein activation cascade (GO:0072376)3.53841559
107modulation by symbiont of host immune response (GO:0052553)3.52187872
108positive regulation by symbiont of host defense response (GO:0052509)3.52187872
109modulation by symbiont of host defense response (GO:0052031)3.52187872
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.52187872
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.52187872
112positive regulation by organism of defense response of other organism involved in symbiotic interact3.52187872
113immunoglobulin mediated immune response (GO:0016064)3.51773627
114intestinal absorption (GO:0050892)3.50467363
115cytolysis (GO:0019835)3.49698198
116complement activation, classical pathway (GO:0006958)3.48929945
117exogenous drug catabolic process (GO:0042738)3.45976378
118acute-phase response (GO:0006953)3.45545606
119complement activation (GO:0006956)3.45200194
120antigen processing and presentation of endogenous antigen (GO:0019883)3.44263347
121regulation of B cell differentiation (GO:0045577)3.42241196
122negative thymic T cell selection (GO:0045060)3.39921919
123cellular extravasation (GO:0045123)3.37279556
124detection of other organism (GO:0098543)3.36170648
125negative T cell selection (GO:0043383)3.31262789
126negative regulation of erythrocyte differentiation (GO:0045647)3.28449130
127microglial cell activation (GO:0001774)3.24330167
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24092697
129B cell mediated immunity (GO:0019724)3.23772463
130response to interleukin-15 (GO:0070672)3.21196681
131antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20313330
132detection of molecule of bacterial origin (GO:0032490)3.18584431
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15822840
134leukocyte aggregation (GO:0070486)3.12641902
135macrophage activation involved in immune response (GO:0002281)3.11672940
136B cell receptor signaling pathway (GO:0050853)3.11475952
137positive regulation of granulocyte differentiation (GO:0030854)3.11074893
138positive thymic T cell selection (GO:0045059)3.10470735
139detection of bacterium (GO:0016045)3.08715467
140detection of external biotic stimulus (GO:0098581)3.06576307
141T cell migration (GO:0072678)3.04412517
142positive regulation of mast cell activation (GO:0033005)2.99155176
143regulation of alpha-beta T cell proliferation (GO:0046640)2.93305989
144definitive hemopoiesis (GO:0060216)2.92578259
145regulation of mast cell degranulation (GO:0043304)2.92309049
146neutrophil activation (GO:0042119)2.91252255
147myeloid cell activation involved in immune response (GO:0002275)2.90661568
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87554074
149positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87171461
150response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82154012
151response to host immune response (GO:0052572)2.82154012
152detection of biotic stimulus (GO:0009595)2.80825540
153defense response to protozoan (GO:0042832)2.78996372
154response to muramyl dipeptide (GO:0032495)2.76535487
155positive T cell selection (GO:0043368)2.74089328
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.73422289
157macrophage activation (GO:0042116)2.73105932
158negative regulation of T cell mediated immunity (GO:0002710)2.73095086
159positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72116686
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70374531
161granulocyte activation (GO:0036230)2.69697524
162regulation of mast cell activation involved in immune response (GO:0033006)2.68394159
163positive regulation of interferon-alpha production (GO:0032727)2.66532176
164regulation of hypersensitivity (GO:0002883)2.65211542
165response to protozoan (GO:0001562)2.65116446
166positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64373280
167regulation of mast cell activation (GO:0033003)2.63136412
168regulation of interferon-alpha production (GO:0032647)2.62674282
169regulation of interferon-beta biosynthetic process (GO:0045357)2.61583861
170Peyers patch development (GO:0048541)2.60229965
171mucosal-associated lymphoid tissue development (GO:0048537)2.60229965
172positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58850349
173regulation of regulatory T cell differentiation (GO:0045589)2.56913832
174positive regulation of mast cell activation involved in immune response (GO:0033008)2.56358267
175positive regulation of mast cell degranulation (GO:0043306)2.56358267
176positive regulation of humoral immune response (GO:0002922)2.55864440
177T cell selection (GO:0045058)2.55318424
178cellular response to interleukin-15 (GO:0071350)2.54683581
179positive regulation of B cell mediated immunity (GO:0002714)2.54186541
180positive regulation of immunoglobulin mediated immune response (GO:0002891)2.54186541
181respiratory burst (GO:0045730)2.52628538
182regulation of leukocyte degranulation (GO:0043300)2.51963538
183cellular response to ethanol (GO:0071361)2.51892638
184mast cell activation (GO:0045576)2.49849646
185negative regulation of leukocyte mediated immunity (GO:0002704)2.49792182
186myeloid dendritic cell activation (GO:0001773)2.48602273
187regulation of granulocyte differentiation (GO:0030852)2.45850060
188positive regulation of isotype switching (GO:0045830)2.45320764
189positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.45099250
190regulation of B cell mediated immunity (GO:0002712)2.44430699
191interferon-gamma-mediated signaling pathway (GO:0060333)2.43729854
192regulation of tolerance induction (GO:0002643)2.43217851
193positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.43168108
194leukocyte degranulation (GO:0043299)2.43159338
195regulation of T-helper 1 cell differentiation (GO:0045625)2.42202093
196response to host defenses (GO:0052200)2.41543085
197response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41543085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.83344195
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.82724737
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.74291856
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.18194123
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72877173
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61962779
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.05250689
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01323569
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78056863
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.58608530
11* MYB_26560356_Chip-Seq_TH2_Human2.72926213
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37831905
13* SPI1_23547873_ChIP-Seq_NB4_Human2.37368183
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.34956834
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21556335
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16808131
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11213184
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06564213
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03448323
20GATA1_22025678_ChIP-Seq_K562_Human2.02248728
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01409680
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1201451
23VDR_24763502_ChIP-Seq_THP-1_Human1.99175642
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.96705260
25* SPI1_23127762_ChIP-Seq_K562_Human1.93469916
26* GATA3_27048872_Chip-Seq_THYMUS_Human1.84880317
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81709993
28MYC_22102868_ChIP-Seq_BL_Human1.78522700
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73880792
30* MAF_26560356_Chip-Seq_TH1_Human1.70401702
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70070922
32VDR_24787735_ChIP-Seq_THP-1_Human1.70051744
33* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68702603
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.67272975
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64826196
36GATA3_26560356_Chip-Seq_TH2_Human1.63736076
37UTX_26944678_Chip-Seq_JUKART_Human1.62456282
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58853680
39VDR_21846776_ChIP-Seq_THP-1_Human1.57314772
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57314754
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55181714
42* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54870029
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54488659
44CLOCK_20551151_ChIP-Seq_293T_Human1.53938612
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53646712
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50858289
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49436459
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.44463437
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41064969
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36014632
51* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32178676
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31357136
53SCL_19346495_ChIP-Seq_HPC-7_Human1.28405240
54HTT_18923047_ChIP-ChIP_STHdh_Human1.28064967
55* GATA4_25053715_ChIP-Seq_YYC3_Human1.27392305
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24512887
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21179609
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19324537
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15863659
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15652890
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12775614
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10639826
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10146156
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09569162
65E2F7_22180533_ChIP-Seq_HELA_Human1.05469613
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04058302
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01660630
68* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00435515
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99897113
70MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99659586
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99296042
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98065901
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97470693
74* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96944249
75* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95602220
76* GATA6_25053715_ChIP-Seq_YYC3_Human0.94710355
77* GATA1_19941827_ChIP-Seq_MEL_Mouse0.93830409
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93629708
79MAF_26560356_Chip-Seq_TH2_Human0.93417392
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92840470
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92840470
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92840470
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92086463
84* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91535305
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91031063
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88927423
87IRF8_27001747_Chip-Seq_BMDM_Mouse0.87761745
88* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87403928
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86845752
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.85265376
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85193171
92* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85065526
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84804026
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84207501
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82090396
96* GATA2_19941826_ChIP-Seq_K562_Human0.82013096
97GATA3_26560356_Chip-Seq_TH1_Human0.81381601
98ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80532115
99NCOR1_26117541_ChIP-Seq_K562_Human0.79749227
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79228417
101* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78692868
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78645415
103* SMRT_27268052_Chip-Seq_Bcells_Human0.78204557
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77993225
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77945368
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.77512800
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.76833920
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.75937745
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75751145
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74012228
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73739799
112BP1_19119308_ChIP-ChIP_Hs578T_Human0.73396109
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73106001
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72907193
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72093714
116* SOX2_20726797_ChIP-Seq_SW620_Human0.71316304
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70626080
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.70174948
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69216456
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.68762524
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68664135
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67877577
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65868063
124* RARA_24833708_ChIP-Seq_LIVER_Mouse0.65500395
125* GATA1_19941826_ChIP-Seq_K562_Human0.63839504
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63279027
127ZNF263_19887448_ChIP-Seq_K562_Human0.63003654
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61156038
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.60995315
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60973019
131* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.60136217
132CEBPB_22108803_ChIP-Seq_LS180_Human0.60098567
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.60023324
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.58247972
135* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.56873222
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.56785482
137AR_21909140_ChIP-Seq_LNCAP_Human0.55908447
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55768437
139* RUNX_20019798_ChIP-Seq_JUKART_Human0.54635270
140* AR_20517297_ChIP-Seq_VCAP_Human0.52513290
141* STAT1_17558387_ChIP-Seq_HELA_Human0.52335952
142EGR1_19032775_ChIP-ChIP_M12_Human0.51265900
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.51226413
144MYB_26560356_Chip-Seq_TH1_Human0.50066349
145CDX2_22108803_ChIP-Seq_LS180_Human0.50013866
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.49665259
147PU_27001747_Chip-Seq_BMDM_Mouse0.49235142
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.49217624
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.49217624
150MYC_19915707_ChIP-ChIP_AK7_Human0.47414670
151LXR_22292898_ChIP-Seq_THP-1_Human0.47381677
152TCF7_22412390_ChIP-Seq_EML_Mouse0.46617252
153* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.46390655
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46337539
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.46317829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.68248697
2MP0002139_abnormal_hepatobiliary_system7.57050675
3MP0005085_abnormal_gallbladder_physiolo6.13281556
4MP0005365_abnormal_bile_salt5.84889380
5MP0008875_abnormal_xenobiotic_pharmacok4.98979947
6MP0003252_abnormal_bile_duct3.95510132
7MP0003806_abnormal_nucleotide_metabolis3.55153879
8MP0010329_abnormal_lipoprotein_level3.54273883
9MP0001666_abnormal_nutrient_absorption3.22805444
10MP0003303_peritoneal_inflammation3.19527296
11MP0009840_abnormal_foam_cell3.07695129
12MP0005671_abnormal_response_to2.55260226
13MP0001800_abnormal_humoral_immune2.51914763
14MP0005332_abnormal_amino_acid2.51276944
15MP0005083_abnormal_biliary_tract2.48591824
16MP0003191_abnormal_cellular_cholesterol2.32626733
17MP0005000_abnormal_immune_tolerance2.32368319
18MP0002148_abnormal_hypersensitivity_rea2.28008274
19MP0002396_abnormal_hematopoietic_system2.25501604
20MP0002723_abnormal_immune_serum2.15670316
21MP0003763_abnormal_thymus_physiology2.14290617
22MP0002452_abnormal_antigen_presenting2.14013291
23MP0005397_hematopoietic_system_phenotyp2.12874458
24MP0001545_abnormal_hematopoietic_system2.12874458
25* MP0000609_abnormal_liver_physiology2.12005198
26MP0001790_abnormal_immune_system2.11709943
27MP0005387_immune_system_phenotype2.11709943
28MP0009278_abnormal_bone_marrow2.10054572
29MP0004019_abnormal_vitamin_homeostasis2.07993437
30MP0002420_abnormal_adaptive_immunity2.04928167
31MP0001819_abnormal_immune_cell2.03504732
32MP0000685_abnormal_immune_system1.99588355
33MP0003868_abnormal_feces_composition1.97649813
34MP0002118_abnormal_lipid_homeostasis1.94906284
35MP0002398_abnormal_bone_marrow1.86468749
36MP0003195_calcinosis1.84038929
37* MP0005319_abnormal_enzyme/_coenzyme1.80780457
38MP0002138_abnormal_hepatobiliary_system1.80701580
39MP0009697_abnormal_copulation1.78832878
40MP0008057_abnormal_DNA_replication1.73776237
41MP0009333_abnormal_splenocyte_physiolog1.70302563
42MP0000716_abnormal_immune_system1.68933864
43MP0010234_abnormal_vibrissa_follicle1.68686203
44MP0000689_abnormal_spleen_morphology1.68180432
45MP0000465_gastrointestinal_hemorrhage1.66677759
46MP0002405_respiratory_system_inflammati1.64582230
47MP0001764_abnormal_homeostasis1.62984238
48MP0003183_abnormal_peptide_metabolism1.58545548
49MP0002722_abnormal_immune_system1.58532370
50MP0003172_abnormal_lysosome_physiology1.52728112
51MP0005584_abnormal_enzyme/coenzyme_acti1.48709834
52MP0002429_abnormal_blood_cell1.43549525
53MP0009643_abnormal_urine_homeostasis1.40226895
54MP0001533_abnormal_skeleton_physiology1.36833888
55MP0003656_abnormal_erythrocyte_physiolo1.35160178
56MP0000703_abnormal_thymus_morphology1.33107912
57MP0004808_abnormal_hematopoietic_stem1.31752476
58MP0004264_abnormal_extraembryonic_tissu1.29506920
59* MP0000598_abnormal_liver_morphology1.22465232
60MP0005310_abnormal_salivary_gland1.22426649
61MP0009764_decreased_sensitivity_to1.17277520
62MP0001851_eye_inflammation1.15840633
63MP0000604_amyloidosis1.15449643
64MP0003186_abnormal_redox_activity1.08601901
65MP0005464_abnormal_platelet_physiology1.08524626
66MP0005451_abnormal_body_composition1.08288640
67* MP0008469_abnormal_protein_level1.05702892
68MP0005636_abnormal_mineral_homeostasis1.05695205
69MP0000858_altered_metastatic_potential1.04711097
70MP0009763_increased_sensitivity_to1.04077100
71MP0002006_tumorigenesis1.03434320
72MP0008004_abnormal_stomach_pH1.00840030
73MP0003705_abnormal_hypodermis_morpholog1.00815392
74MP0002998_abnormal_bone_remodeling1.00105590
75MP0005647_abnormal_sex_gland0.99809123
76MP0003011_delayed_dark_adaptation0.98280494
77MP0003828_pulmonary_edema0.96599284
78MP0002009_preneoplasia0.95713956
79* MP0009642_abnormal_blood_homeostasis0.91377427
80MP0003436_decreased_susceptibility_to0.91253559
81MP0002876_abnormal_thyroid_physiology0.90695628
82MP0005084_abnormal_gallbladder_morpholo0.90290168
83MP0009765_abnormal_xenobiotic_induced0.89672329
84MP0010368_abnormal_lymphatic_system0.87454475
85MP0003300_gastrointestinal_ulcer0.85282847
86MP0002254_reproductive_system_inflammat0.85134304
87MP0008260_abnormal_autophagy0.80988391
88MP0003448_altered_tumor_morphology0.80689991
89* MP0002019_abnormal_tumor_incidence0.80234339
90MP0004883_abnormal_blood_vessel0.79104907
91MP0005408_hypopigmentation0.78067935
92MP0010307_abnormal_tumor_latency0.74993029
93MP0010155_abnormal_intestine_physiology0.73793029
94MP0005376_homeostasis/metabolism_phenot0.73469012
95MP0001873_stomach_inflammation0.72269589
96MP0005410_abnormal_fertilization0.71940366
97MP0003724_increased_susceptibility_to0.70971166
98MP0004147_increased_porphyrin_level0.70713590
99MP0003718_maternal_effect0.70497292
100MP0005220_abnormal_exocrine_pancreas0.68891327
101MP0002078_abnormal_glucose_homeostasis0.67359024
102MP0005670_abnormal_white_adipose0.67214249
103MP0005334_abnormal_fat_pad0.67059197
104MP0002136_abnormal_kidney_physiology0.66503750
105MP0002166_altered_tumor_susceptibility0.65478538
106MP0005164_abnormal_response_to0.64049038
107MP0002971_abnormal_brown_adipose0.63350672
108MP0000343_altered_response_to0.63205153
109MP0001845_abnormal_inflammatory_respons0.62587730
110MP0005166_decreased_susceptibility_to0.62392040
111MP0002822_catalepsy0.61279215
112MP0003075_altered_response_to0.59735806
113MP0009053_abnormal_anal_canal0.59507847
114MP0006036_abnormal_mitochondrial_physio0.58312189
115MP0008873_increased_physiological_sensi0.58150504
116MP0001756_abnormal_urination0.57858170
117MP0005448_abnormal_energy_balance0.57497887
118MP0009785_altered_susceptibility_to0.55397445
119MP0002928_abnormal_bile_duct0.54584003
120MP0003638_abnormal_response/metabolism_0.54566858
121MP0005266_abnormal_metabolism0.54357590
122MP0005025_abnormal_response_to0.53409524
123MP0001663_abnormal_digestive_system0.52927933
124MP0001853_heart_inflammation0.52037527
125MP0005535_abnormal_body_temperature0.51778011
126MP0004947_skin_inflammation0.50787437
127MP0002419_abnormal_innate_immunity0.50243370
128MP0001765_abnormal_ion_homeostasis0.50182419
129MP0008872_abnormal_physiological_respon0.46729542
130MP0000639_abnormal_adrenal_gland0.46606798
131MP0001835_abnormal_antigen_presentation0.46100279
132MP0004130_abnormal_muscle_cell0.45424442
133MP0003690_abnormal_glial_cell0.44773326
134MP0000477_abnormal_intestine_morphology0.43603574
135MP0006082_CNS_inflammation0.42199312
136MP0009115_abnormal_fat_cell0.40302500
137MP0003866_abnormal_defecation0.40173874
138MP0000249_abnormal_blood_vessel0.39508618
139MP0002132_abnormal_respiratory_system0.39363642
140MP0005075_abnormal_melanosome_morpholog0.39272142
141MP0003329_amyloid_beta_deposits0.39255178
142MP0008874_decreased_physiological_sensi0.39148082
143MP0005381_digestive/alimentary_phenotyp0.38554644
144MP0003953_abnormal_hormone_level0.38475426
145MP0003943_abnormal_hepatobiliary_system0.38205123
146MP0005058_abnormal_lysosome_morphology0.37978945
147MP0002135_abnormal_kidney_morphology0.37229967
148MP0009384_cardiac_valve_regurgitation0.36183747

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.01935272
2Deep venous thrombosis (HP:0002625)6.82503223
3Hypobetalipoproteinemia (HP:0003563)6.66334418
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57548023
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.44201994
6Prolonged partial thromboplastin time (HP:0003645)6.22333514
7Xanthomatosis (HP:0000991)5.87758822
8Complement deficiency (HP:0004431)5.10044804
9Hyperlipoproteinemia (HP:0010980)4.85701670
10Hypolipoproteinemia (HP:0010981)4.65154741
11Joint hemorrhage (HP:0005261)4.58677607
12Fat malabsorption (HP:0002630)4.57908106
13Abnormality of the common coagulation pathway (HP:0010990)4.54471839
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52488020
15Eczematoid dermatitis (HP:0000976)4.34230343
16Epidermoid cyst (HP:0200040)4.33454944
17Conjugated hyperbilirubinemia (HP:0002908)4.32868988
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26330112
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22706281
20Hyperammonemia (HP:0001987)4.20341771
21Recurrent abscess formation (HP:0002722)4.07515212
22Recurrent bacterial skin infections (HP:0005406)4.07436889
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06822890
24Myositis (HP:0100614)4.06730885
25Prolonged bleeding time (HP:0003010)4.06106795
26Stomatitis (HP:0010280)4.04334634
27T lymphocytopenia (HP:0005403)3.95307418
28Abnormality of methionine metabolism (HP:0010901)3.89541301
29Retrobulbar optic neuritis (HP:0100654)3.82490550
30Optic neuritis (HP:0100653)3.82490550
31Orchitis (HP:0100796)3.82467113
32Acanthocytosis (HP:0001927)3.79555804
33Abnormality of T cell number (HP:0011839)3.77197459
34Abnormality of pyrimidine metabolism (HP:0004353)3.76717990
35Hypercholesterolemia (HP:0003124)3.75477466
36Ketosis (HP:0001946)3.75244524
37Hyperglycinemia (HP:0002154)3.75124161
38Abnormality of complement system (HP:0005339)3.72429130
39Abnormality of the intrinsic pathway (HP:0010989)3.67717066
40Hyperglycinuria (HP:0003108)3.66622933
41Hypoalphalipoproteinemia (HP:0003233)3.61420253
42Recurrent fungal infections (HP:0002841)3.58115279
43Elevated erythrocyte sedimentation rate (HP:0003565)3.57063683
44Abnormality of macrophages (HP:0004311)3.55547923
45Abnormality of glycine metabolism (HP:0010895)3.49582088
46Abnormality of serine family amino acid metabolism (HP:0010894)3.49582088
47Hypoglycemic coma (HP:0001325)3.45118088
48Hyperbilirubinemia (HP:0002904)3.44991130
49Meningitis (HP:0001287)3.35366514
50Encephalitis (HP:0002383)3.34157869
51Steatorrhea (HP:0002570)3.24631505
52Hypochromic microcytic anemia (HP:0004840)3.18361220
53Spontaneous abortion (HP:0005268)3.18082002
54Obstructive lung disease (HP:0006536)3.16087499
55Chronic obstructive pulmonary disease (HP:0006510)3.16087499
56Panhypogammaglobulinemia (HP:0003139)3.14767854
57Recurrent viral infections (HP:0004429)3.14652092
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13674245
59Abnormal delayed hypersensitivity skin test (HP:0002963)3.10379255
60Spontaneous hematomas (HP:0007420)3.10315910
61Autoimmune hemolytic anemia (HP:0001890)3.06733980
62Abnormality of nucleobase metabolism (HP:0010932)3.05199404
63Abnormality of fatty-acid metabolism (HP:0004359)3.04486544
64Recurrent skin infections (HP:0001581)3.02375563
65Keratoconjunctivitis sicca (HP:0001097)2.98182764
66Abnormality of T cells (HP:0002843)2.95891994
67Mediastinal lymphadenopathy (HP:0100721)2.94838432
68Gastrointestinal infarctions (HP:0005244)2.92668121
69Purpura (HP:0000979)2.91326887
70Abnormality of the prostate (HP:0008775)2.91058436
71Arterial thrombosis (HP:0004420)2.88817847
72Recurrent cutaneous fungal infections (HP:0011370)2.88141299
73Chronic mucocutaneous candidiasis (HP:0002728)2.88141299
74Vasculitis (HP:0002633)2.82352743
75Myocardial infarction (HP:0001658)2.82002452
76Systemic lupus erythematosus (HP:0002725)2.80153274
77Poikilocytosis (HP:0004447)2.79480822
78Increased IgM level (HP:0003496)2.77365217
79Leukocytosis (HP:0001974)2.76782411
80Hepatocellular carcinoma (HP:0001402)2.74132388
81Keratoconjunctivitis (HP:0001096)2.74071000
82Autoimmune thrombocytopenia (HP:0001973)2.73591015
83Gingival bleeding (HP:0000225)2.73043158
84Glomerulonephritis (HP:0000099)2.69750447
85Abnormality of purine metabolism (HP:0004352)2.69440112
86Granulocytopenia (HP:0001913)2.69251832
87Menorrhagia (HP:0000132)2.60812008
88Malnutrition (HP:0004395)2.60647060
89Metabolic acidosis (HP:0001942)2.60390704
90Skin nodule (HP:0200036)2.57267052
91Abnormality of B cell number (HP:0010975)2.56737800
92Recurrent gram-negative bacterial infections (HP:0005420)2.55178686
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53151044
94Abnormality of serum amino acid levels (HP:0003112)2.53090820
95Ketoacidosis (HP:0001993)2.52318439
96Delayed CNS myelination (HP:0002188)2.51253564
97Petechiae (HP:0000967)2.49667260
98Joint swelling (HP:0001386)2.49045786
99Eosinophilia (HP:0001880)2.48132282
100Hemoptysis (HP:0002105)2.45826279
101Pulmonary infiltrates (HP:0002113)2.45795051
102Esophageal varix (HP:0002040)2.45354949
103Chest pain (HP:0100749)2.43560619
104Vascular calcification (HP:0004934)2.43482673
105Gingivitis (HP:0000230)2.43208549
106Agammaglobulinemia (HP:0004432)2.41954361
107Spastic diplegia (HP:0001264)2.40780585
108IgM deficiency (HP:0002850)2.39401855
109Gangrene (HP:0100758)2.38047366
110Thrombophlebitis (HP:0004418)2.37255199
111Increased mean platelet volume (HP:0011877)2.31024314
112Increased cerebral lipofuscin (HP:0011813)2.28862080
113Thrombocytosis (HP:0001894)2.28073319
114Dicarboxylic aciduria (HP:0003215)2.27519036
115Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27519036
116Pancreatitis (HP:0001733)2.26976887
117Cholecystitis (HP:0001082)2.26753947
118Abnormal gallbladder physiology (HP:0012438)2.26753947
119Cellulitis (HP:0100658)2.24516767
120Anorexia (HP:0002039)2.23741668
121Amyloidosis (HP:0011034)2.23374334
122Inflammation of the large intestine (HP:0002037)2.23208019
123Abnormality of liposaccharide metabolism (HP:0010968)2.23095650
124Abnormality of glycosphingolipid metabolism (HP:0004343)2.23095650
125Abnormality of glycolipid metabolism (HP:0010969)2.23095650
126Urticaria (HP:0001025)2.22749881
127Sensorimotor neuropathy (HP:0007141)2.21688174
128Abnormal platelet volume (HP:0011876)2.19138528
129Acute lymphatic leukemia (HP:0006721)2.19094064
130Abnormality of eosinophils (HP:0001879)2.18824174
131Hypoglycemic seizures (HP:0002173)2.17433104
132Abnormality of T cell physiology (HP:0011840)2.15880973
133Lethargy (HP:0001254)2.15272122
134Gastrointestinal inflammation (HP:0004386)2.15230593
135B lymphocytopenia (HP:0010976)2.14790308
136Colitis (HP:0002583)2.14699745
137Vacuolated lymphocytes (HP:0001922)2.14625758
138Abnormality of proline metabolism (HP:0010907)2.13256147
139Hydroxyprolinuria (HP:0003080)2.13256147
140Nephritis (HP:0000123)2.12535103
141Cholelithiasis (HP:0001081)2.11781618
142Hemorrhage of the eye (HP:0011885)2.11449117
143Abnormal gallbladder morphology (HP:0012437)2.11386399
144Conjunctival telangiectasia (HP:0000524)2.10737504
145IgG deficiency (HP:0004315)2.10597911
146Increased serum ferritin (HP:0003281)2.10041149
147Cardiovascular calcification (HP:0011915)2.09981000
148Stomach cancer (HP:0012126)2.08239755
149Prostate neoplasm (HP:0100787)2.08190951
150Amaurosis fugax (HP:0100576)2.08025223
151Renal cortical cysts (HP:0000803)2.06726884
152Combined immunodeficiency (HP:0005387)2.06208690
153Acute hepatic failure (HP:0006554)2.04491736
154Irritability (HP:0000737)2.03889077
155Abnormality of the pleura (HP:0002103)2.03522643
156Late onset (HP:0003584)2.03373397
157Severe combined immunodeficiency (HP:0004430)2.03114443
158Neonatal onset (HP:0003623)2.01416281
159Gout (HP:0001997)2.00032399
160Mitral stenosis (HP:0001718)1.99176217
161Epistaxis (HP:0000421)1.97606888
162Generalized aminoaciduria (HP:0002909)1.96401038
163Abnormality of transition element cation homeostasis (HP:0011030)1.94169578
164Abnormal platelet function (HP:0011869)1.93351397
165Impaired platelet aggregation (HP:0003540)1.93351397
166Abnormality of iron homeostasis (HP:0011031)1.86974759
167Abnormality of vitamin metabolism (HP:0100508)1.85486606
168Pulmonary embolism (HP:0002204)1.83729266
169Elevated hepatic transaminases (HP:0002910)1.82760361
170Brushfield spots (HP:0001088)1.80639849
171Vomiting (HP:0002013)1.78903470
172Abnormal enzyme/coenzyme activity (HP:0012379)1.76674064
173Abnormality of the gallbladder (HP:0005264)1.75009612
174Reticulocytosis (HP:0001923)1.74995714
175Opisthotonus (HP:0002179)1.74097097
176Alkalosis (HP:0001948)1.72988782
177Hypertriglyceridemia (HP:0002155)1.72139997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.06835152
2BCKDK4.82767825
3ERN13.90136586
4FGFR43.23083974
5FRK3.11454388
6SIK12.87646342
7FES2.43802368
8MST1R2.43273481
9GRK62.31185916
10BLK2.27036102
11FLT32.19004639
12INSRR2.06397648
13PKN21.99718123
14TYK21.96208166
15MAPK111.90801392
16RIPK11.78035103
17ERBB41.77702099
18MAP2K31.76030394
19PIK3CA1.74196126
20MAP2K41.69165104
21PTK61.60976096
22PIK3CG1.59892313
23PRPF4B1.58048371
24KIT1.57023388
25MAP3K141.55701159
26MAP3K101.54701186
27LATS11.51429136
28MARK31.45106931
29ACVR1B1.44773805
30MAP3K71.43660511
31MAP4K11.42260174
32FGR1.41122785
33BMPR21.40262297
34IKBKB1.37336281
35LCK1.37021791
36HCK1.36545529
37TNK21.35562686
38NEK91.25372333
39TBK11.21202659
40EEF2K1.17959336
41JAK21.17376685
42IRAK11.14392269
43MAP3K131.08734480
44JAK11.08275343
45CDK61.06240461
46ERBB21.05070368
47STK101.01225768
48PRKAA20.97659891
49RIPK40.96120472
50MAP3K60.95392430
51NUAK10.92586561
52IKBKE0.91881996
53MATK0.91381398
54CSF1R0.91122226
55CDK120.90672163
56SCYL20.89148325
57MAPK40.89137443
58KDR0.88514706
59TIE10.87832819
60ABL20.86971609
61JAK30.85318549
62TRIB30.85241704
63BTK0.84407079
64CSK0.83500162
65MAP3K30.82892215
66MAP3K110.82293152
67MAP2K60.80277419
68AKT30.74339911
69FGFR30.73032886
70ZAP700.72224336
71TEC0.69324987
72SGK30.68810765
73YES10.67351823
74STK40.67031206
75CAMK1D0.66529677
76PLK40.65826601
77TAOK10.65679572
78IRAK30.65190913
79PRKG20.65171496
80MAP2K20.64629801
81TGFBR20.61850196
82TESK20.60802614
83CDK40.60391395
84PRKCQ0.60254197
85STK30.56755969
86GRK70.56559259
87CHUK0.56052831
88NLK0.56047394
89CLK10.55814834
90TXK0.54205334
91DAPK20.53129768
92MAP3K50.51417930
93PTK20.50288404
94IRAK20.48922994
95ITK0.48439935
96TGFBR10.48038548
97LYN0.47178999
98MAP3K80.47050600
99PDK10.46479577
100EPHB10.46324260
101PRKACG0.46211699
102PDPK10.43985728
103MYLK0.43973957
104MST40.43730012
105TAF10.43015202
106SYK0.42967491
107SGK20.42793213
108MAP3K20.42445545
109WNK10.42289459
110RPS6KL10.41751400
111RPS6KC10.41751400
112MAP3K10.41191464
113FYN0.40625473
114PIM10.40500149
115EPHA40.37916277
116CDK90.37855523
117EPHA30.37734213
118RPS6KA60.37477054
119TAOK20.36047239
120EGFR0.35771053
121IGF1R0.35747863
122HIPK20.34094982
123MAP2K10.32800690
124CAMKK20.32528180
125MAPK30.32277010
126DYRK1B0.31964852
127EIF2AK30.31730184
128RET0.30975430
129MAPK70.30480648
130PRKAA10.30261286
131PRKCZ0.29584714
132IRAK40.29465402
133RPS6KB10.29170857
134RPS6KA40.28863924
135GSK3A0.28363975
136MELK0.28317226
137BRD40.28249321
138LRRK20.27414827

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41188771
2Nitrogen metabolism_Homo sapiens_hsa009103.65629507
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60569976
4Arginine biosynthesis_Homo sapiens_hsa002203.05826793
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93342657
6Allograft rejection_Homo sapiens_hsa053302.78644423
7Complement and coagulation cascades_Homo sapiens_hsa046102.73253884
8Leishmaniasis_Homo sapiens_hsa051402.73062888
9Tryptophan metabolism_Homo sapiens_hsa003802.66616399
10Graft-versus-host disease_Homo sapiens_hsa053322.62073463
11Autoimmune thyroid disease_Homo sapiens_hsa053202.54267993
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47697984
13Fatty acid degradation_Homo sapiens_hsa000712.41813140
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40142328
15Asthma_Homo sapiens_hsa053102.36017435
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35440996
17Primary immunodeficiency_Homo sapiens_hsa053402.35079216
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30304691
19Caffeine metabolism_Homo sapiens_hsa002322.22195883
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18779667
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12857086
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12517230
23Peroxisome_Homo sapiens_hsa041461.99061378
24Histidine metabolism_Homo sapiens_hsa003401.98614251
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.97804347
26Osteoclast differentiation_Homo sapiens_hsa043801.96464506
27Chemical carcinogenesis_Homo sapiens_hsa052041.95917983
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94007722
29B cell receptor signaling pathway_Homo sapiens_hsa046621.91414671
30PPAR signaling pathway_Homo sapiens_hsa033201.89367038
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.86072068
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85999697
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85486132
34Antigen processing and presentation_Homo sapiens_hsa046121.84144270
35Staphylococcus aureus infection_Homo sapiens_hsa051501.82627431
36Type I diabetes mellitus_Homo sapiens_hsa049401.81763435
37Bile secretion_Homo sapiens_hsa049761.79997197
38Butanoate metabolism_Homo sapiens_hsa006501.76098435
39Hematopoietic cell lineage_Homo sapiens_hsa046401.74802283
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.73904183
41Sulfur metabolism_Homo sapiens_hsa009201.73874711
42Fat digestion and absorption_Homo sapiens_hsa049751.72484282
43Propanoate metabolism_Homo sapiens_hsa006401.70053118
44Retinol metabolism_Homo sapiens_hsa008301.67850706
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67182502
46Starch and sucrose metabolism_Homo sapiens_hsa005001.63436948
47beta-Alanine metabolism_Homo sapiens_hsa004101.62479027
48Selenocompound metabolism_Homo sapiens_hsa004501.57867174
49Fatty acid metabolism_Homo sapiens_hsa012121.56946235
50Measles_Homo sapiens_hsa051621.51173579
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50344306
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49535189
53Tuberculosis_Homo sapiens_hsa051521.46232472
54T cell receptor signaling pathway_Homo sapiens_hsa046601.44587320
55Herpes simplex infection_Homo sapiens_hsa051681.44534796
56Platelet activation_Homo sapiens_hsa046111.43539116
57ABC transporters_Homo sapiens_hsa020101.40874184
58Other glycan degradation_Homo sapiens_hsa005111.39944014
59Folate biosynthesis_Homo sapiens_hsa007901.32787836
60Influenza A_Homo sapiens_hsa051641.31591730
61Phenylalanine metabolism_Homo sapiens_hsa003601.30595353
62Vitamin digestion and absorption_Homo sapiens_hsa049771.28678390
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28162236
64Pyruvate metabolism_Homo sapiens_hsa006201.20757588
65Toxoplasmosis_Homo sapiens_hsa051451.20604890
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19704699
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.19287924
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.19286049
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19230664
70Acute myeloid leukemia_Homo sapiens_hsa052211.18215906
71Tyrosine metabolism_Homo sapiens_hsa003501.17006812
72Maturity onset diabetes of the young_Homo sapiens_hsa049501.15657918
73Malaria_Homo sapiens_hsa051441.10083822
74Legionellosis_Homo sapiens_hsa051341.08724964
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06297376
76Biosynthesis of amino acids_Homo sapiens_hsa012301.05987329
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04611415
78Rheumatoid arthritis_Homo sapiens_hsa053231.04572267
79Cyanoamino acid metabolism_Homo sapiens_hsa004601.03932603
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03621221
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00739781
82TNF signaling pathway_Homo sapiens_hsa046680.99115261
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98990599
84Carbon metabolism_Homo sapiens_hsa012000.98744298
85Chemokine signaling pathway_Homo sapiens_hsa040620.98168313
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98085633
87Arachidonic acid metabolism_Homo sapiens_hsa005900.97374355
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96377970
89Lysine degradation_Homo sapiens_hsa003100.91912317
90Viral myocarditis_Homo sapiens_hsa054160.90160963
91Fatty acid elongation_Homo sapiens_hsa000620.89475973
92Arginine and proline metabolism_Homo sapiens_hsa003300.85790604
93Sulfur relay system_Homo sapiens_hsa041220.84596023
94Glycerolipid metabolism_Homo sapiens_hsa005610.81548468
95Steroid biosynthesis_Homo sapiens_hsa001000.78556441
96Hepatitis B_Homo sapiens_hsa051610.76010470
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75645036
98One carbon pool by folate_Homo sapiens_hsa006700.72996373
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72640713
100Glutathione metabolism_Homo sapiens_hsa004800.71658134
101Lysosome_Homo sapiens_hsa041420.71586824
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70729812
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66067559
104Non-small cell lung cancer_Homo sapiens_hsa052230.65200007
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61516516
106Galactose metabolism_Homo sapiens_hsa000520.61241076
107Renin-angiotensin system_Homo sapiens_hsa046140.60059633
108Pentose phosphate pathway_Homo sapiens_hsa000300.59900645
109Phagosome_Homo sapiens_hsa041450.57118221
110Apoptosis_Homo sapiens_hsa042100.56736004
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.55786935
112Pancreatic cancer_Homo sapiens_hsa052120.55704246
113Vitamin B6 metabolism_Homo sapiens_hsa007500.50631141
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47066333
115Viral carcinogenesis_Homo sapiens_hsa052030.45127936
116Epstein-Barr virus infection_Homo sapiens_hsa051690.43612305
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42890717
118Fatty acid biosynthesis_Homo sapiens_hsa000610.40376402
119Prolactin signaling pathway_Homo sapiens_hsa049170.40042735
120Metabolic pathways_Homo sapiens_hsa011000.40037791
121Fructose and mannose metabolism_Homo sapiens_hsa000510.37190856
122Chronic myeloid leukemia_Homo sapiens_hsa052200.35258558
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33500246
124Dorso-ventral axis formation_Homo sapiens_hsa043200.30923944
125Shigellosis_Homo sapiens_hsa051310.30380728
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28016076
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26868145
128Insulin resistance_Homo sapiens_hsa049310.26617513
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20003058
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.19044988
131Mineral absorption_Homo sapiens_hsa049780.16361980
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15984369
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15498248
134Prion diseases_Homo sapiens_hsa050200.14332526
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09779411
136Glucagon signaling pathway_Homo sapiens_hsa049220.08119829
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.07757506
138Linoleic acid metabolism_Homo sapiens_hsa005910.07412851
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07270920
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02408147
141African trypanosomiasis_Homo sapiens_hsa051430.00430814
142Insulin signaling pathway_Homo sapiens_hsa04910-0.1410391
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1388386
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1172655
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1009604
146N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1007464
147Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1005125
148Protein digestion and absorption_Homo sapiens_hsa04974-0.0894587
149Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0881233
150Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0875935
151Pertussis_Homo sapiens_hsa05133-0.0682493
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0653670
153AMPK signaling pathway_Homo sapiens_hsa04152-0.0513871
154Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0356670
155Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0071838
156Hepatitis C_Homo sapiens_hsa05160-0.0016071

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »