IQGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71058912
2neutrophil activation involved in immune response (GO:0002283)4.66209887
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65849803
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.65849803
5modulation by symbiont of host immune response (GO:0052553)4.65849803
6positive regulation by symbiont of host defense response (GO:0052509)4.65849803
7modulation by symbiont of host defense response (GO:0052031)4.65849803
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65849803
9detection of molecule of bacterial origin (GO:0032490)4.41062176
10positive regulation of gamma-delta T cell activation (GO:0046645)4.33330427
11regulation of interferon-beta biosynthetic process (GO:0045357)3.86877295
12neutrophil activation (GO:0042119)3.80219570
13antigen processing and presentation of endogenous antigen (GO:0019883)3.77208357
14positive regulation of interferon-alpha production (GO:0032727)3.72965608
15response to peptidoglycan (GO:0032494)3.65940528
16response to muramyl dipeptide (GO:0032495)3.65622877
17detection of other organism (GO:0098543)3.61985672
18granulocyte activation (GO:0036230)3.61904903
19detection of external biotic stimulus (GO:0098581)3.57398871
20regulation of interferon-alpha production (GO:0032647)3.57290874
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53370372
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53370372
23immunoglobulin mediated immune response (GO:0016064)3.52539104
24natural killer cell mediated cytotoxicity (GO:0042267)3.51597385
25natural killer cell mediated immunity (GO:0002228)3.51597385
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.47952636
27macrophage activation involved in immune response (GO:0002281)3.45508085
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37299895
29regulation of B cell receptor signaling pathway (GO:0050855)3.32470238
30iron ion import (GO:0097286)3.30257785
31positive regulation of antigen processing and presentation (GO:0002579)3.25241296
32hypotonic response (GO:0006971)3.22116475
33NIK/NF-kappaB signaling (GO:0038061)3.21946586
34protein localization to endosome (GO:0036010)3.20006163
35response to host immune response (GO:0052572)3.14053293
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14053293
37detection of biotic stimulus (GO:0009595)3.07308714
38leukocyte aggregation (GO:0070486)3.06811215
39detection of bacterium (GO:0016045)3.06348925
40regulation of gamma-delta T cell activation (GO:0046643)3.01543612
41microglial cell activation (GO:0001774)3.00298324
42positive regulation of Cdc42 GTPase activity (GO:0043089)2.99730174
43antigen processing and presentation via MHC class Ib (GO:0002475)2.97203837
44positive regulation of B cell differentiation (GO:0045579)2.94915484
45pinocytosis (GO:0006907)2.91402578
46positive regulation of interferon-beta production (GO:0032728)2.90618505
47respiratory burst (GO:0045730)2.90191453
48regulation of antigen processing and presentation (GO:0002577)2.90024551
49myeloid dendritic cell activation (GO:0001773)2.89745292
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89278002
51response to host (GO:0075136)2.89278002
52response to host defenses (GO:0052200)2.89278002
53nuclear pore complex assembly (GO:0051292)2.89014950
54interferon-gamma-mediated signaling pathway (GO:0060333)2.88000745
55membrane raft organization (GO:0031579)2.87737826
56cell adhesion mediated by integrin (GO:0033627)2.86985716
57myeloid cell activation involved in immune response (GO:0002275)2.84763438
58regulation of gamma-delta T cell differentiation (GO:0045586)2.82587542
59negative regulation of T cell mediated immunity (GO:0002710)2.79645691
60response to type I interferon (GO:0034340)2.78087905
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.77313042
62hepatocyte apoptotic process (GO:0097284)2.76997563
63wound healing, spreading of epidermal cells (GO:0035313)2.76247301
64myeloid dendritic cell differentiation (GO:0043011)2.76097584
65neutrophil mediated immunity (GO:0002446)2.75435994
66B cell mediated immunity (GO:0019724)2.75420112
67regulation of B cell differentiation (GO:0045577)2.75412213
68B cell receptor signaling pathway (GO:0050853)2.75335674
69type I interferon signaling pathway (GO:0060337)2.74054169
70cellular response to type I interferon (GO:0071357)2.74054169
71germinal center formation (GO:0002467)2.73315726
72leukocyte cell-cell adhesion (GO:0007159)2.70578674
73positive thymic T cell selection (GO:0045059)2.70449270
74nuclear pore organization (GO:0006999)2.68076696
75regulation of integrin activation (GO:0033623)2.67873733
76hemidesmosome assembly (GO:0031581)2.67842413
77leukocyte mediated cytotoxicity (GO:0001909)2.66814816
78regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66775390
79response to laminar fluid shear stress (GO:0034616)2.66338576
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66181864
81cytokine secretion (GO:0050663)2.65757164
82cellular extravasation (GO:0045123)2.65066574
83negative regulation of lymphocyte mediated immunity (GO:0002707)2.64456598
84positive regulation of interleukin-12 production (GO:0032735)2.61030166
85response to interleukin-15 (GO:0070672)2.60679905
86regulation of mast cell degranulation (GO:0043304)2.60366421
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58636555
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57200186
89positive regulation of natural killer cell differentiation (GO:0032825)2.55193669
90positive regulation of mast cell activation (GO:0033005)2.55091421
91I-kappaB phosphorylation (GO:0007252)2.54939474
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54915364
93cellular response to ethanol (GO:0071361)2.54887048
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54272741
95cellular response to zinc ion (GO:0071294)2.53218089
96positive regulation of receptor recycling (GO:0001921)2.52011885
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51876194
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.51744313
99embryonic process involved in female pregnancy (GO:0060136)2.51382872
100necroptotic process (GO:0070266)2.50671877
101regulation of leukocyte degranulation (GO:0043300)2.49767151
102modulation by symbiont of host cellular process (GO:0044068)2.49433799
103negative regulation of interleukin-12 production (GO:0032695)2.48424454
104myeloid leukocyte activation (GO:0002274)2.48134515
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47584723
106regulation of necroptotic process (GO:0060544)2.47542327
107regulation of mast cell activation involved in immune response (GO:0033006)2.47327914
108regulation of tolerance induction (GO:0002643)2.47179990
109T-helper 1 type immune response (GO:0042088)2.46351378
110regulation of mast cell activation (GO:0033003)2.46226909
111positive regulation of cellular amide metabolic process (GO:0034250)2.45747520
112positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45542093
113dendritic cell differentiation (GO:0097028)2.45277270
114positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44826624
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.44314786
116production of molecular mediator involved in inflammatory response (GO:0002532)2.44170299
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43276252
118negative regulation of cell killing (GO:0031342)2.43276252
119regulation of macrophage cytokine production (GO:0010935)2.42478028
120defense response to protozoan (GO:0042832)2.42279309
121dendritic cell migration (GO:0036336)2.41274639
122negative regulation of B cell proliferation (GO:0030889)2.40569033
123negative T cell selection (GO:0043383)2.40152161
124macrophage activation (GO:0042116)2.39646189
125negative regulation of leukocyte mediated immunity (GO:0002704)2.39248677
126lymphocyte mediated immunity (GO:0002449)2.38750329
127negative thymic T cell selection (GO:0045060)2.38096286
128positive regulation of mast cell degranulation (GO:0043306)2.37626183
129positive regulation of mast cell activation involved in immune response (GO:0033008)2.37626183
130regulation of T cell tolerance induction (GO:0002664)2.37308553
131positive regulation of leukocyte degranulation (GO:0043302)2.37011741
132regulation of alpha-beta T cell proliferation (GO:0046640)2.36538402
133regulation of interleukin-12 production (GO:0032655)2.36420656
134response to protozoan (GO:0001562)2.35455449
135negative regulation of phagocytosis (GO:0050765)2.35359588
136adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.35346499
137negative regulation of erythrocyte differentiation (GO:0045647)2.29731949
138histone H3-K36 demethylation (GO:0070544)2.28704360
139positive regulation of tolerance induction (GO:0002645)2.27108609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.40937963
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.69272010
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25455439
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.17084162
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.79228112
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.66663768
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64144823
8E2F7_22180533_ChIP-Seq_HELA_Human3.55712392
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.34823000
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34176394
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14894315
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02351783
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01414363
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97275957
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92953934
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82788907
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.77128248
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70655037
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50349308
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43415154
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14907404
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13124240
23MYB_26560356_Chip-Seq_TH2_Human2.05001756
24* SPI1_23547873_ChIP-Seq_NB4_Human1.99065937
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88593311
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86397329
27RUNX_20019798_ChIP-Seq_JUKART_Human1.85177397
28VDR_21846776_ChIP-Seq_THP-1_Human1.85032451
29MAF_26560356_Chip-Seq_TH1_Human1.84684070
30SCL_19346495_ChIP-Seq_HPC-7_Human1.84287840
31VDR_24763502_ChIP-Seq_THP-1_Human1.82685771
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.82072843
33MYB_26560356_Chip-Seq_TH1_Human1.79335127
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74652778
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.69155414
36* SPI1_23127762_ChIP-Seq_K562_Human1.69153011
37MYC_22102868_ChIP-Seq_BL_Human1.68935569
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68400383
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67854525
40PU_27001747_Chip-Seq_BMDM_Mouse1.61706210
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58445933
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54448459
43TCF7_22412390_ChIP-Seq_EML_Mouse1.49022330
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48195654
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.47626076
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46508499
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44105229
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44105229
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43834656
50VDR_24787735_ChIP-Seq_THP-1_Human1.42487491
51UTX_26944678_Chip-Seq_JUKART_Human1.42418004
52CLOCK_20551151_ChIP-Seq_293T_Human1.42093258
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38292256
54GATA1_22025678_ChIP-Seq_K562_Human1.34715831
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33333417
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30973603
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.30338679
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29451892
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29313393
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28332401
61* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27047807
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26599770
63GATA3_27048872_Chip-Seq_THYMUS_Human1.25257457
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.24168959
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23087066
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23002658
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22988712
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22896698
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20417315
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19456744
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.19049723
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18493453
73TFEB_21752829_ChIP-Seq_HELA_Human1.18310300
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.18064938
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.15896026
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14140811
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13985919
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12655106
79* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12536891
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11365733
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.09646997
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.06316692
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04866088
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04311440
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.04308657
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04258673
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03664828
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01139214
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00232561
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99753808
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99725719
92GATA3_26560356_Chip-Seq_TH2_Human0.98168227
93GATA1_19941826_ChIP-Seq_K562_Human0.96840421
94GATA2_19941826_ChIP-Seq_K562_Human0.96689443
95BRD4_25478319_ChIP-Seq_HGPS_Human0.95466235
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.95267698
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94601582
98KDM2B_26808549_Chip-Seq_DND41_Human0.94351713
99* TP63_23658742_ChIP-Seq_EP156T_Human0.93356255
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91533490
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91448819
102* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91300839
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90765421
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90562775
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90254029
106MAF_26560356_Chip-Seq_TH2_Human0.89615759
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88959680
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88633084
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88626371
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87212078
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86911606
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86646687
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86301968
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85851896
115NCOR1_26117541_ChIP-Seq_K562_Human0.83802918
116* CJUN_26792858_Chip-Seq_BT549_Human0.82916379
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82739337
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80306706
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80298742
120GATA6_25053715_ChIP-Seq_YYC3_Human0.79465271
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78573270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.71407943
2MP0003436_decreased_susceptibility_to3.01430824
3MP0000569_abnormal_digit_pigmentation2.88008855
4MP0003303_peritoneal_inflammation2.56815952
5MP0005387_immune_system_phenotype2.54325299
6MP0001790_abnormal_immune_system2.54325299
7MP0000685_abnormal_immune_system2.54153909
8MP0005000_abnormal_immune_tolerance2.43069552
9MP0002148_abnormal_hypersensitivity_rea2.40867420
10MP0002419_abnormal_innate_immunity2.36669637
11MP0009785_altered_susceptibility_to2.35734534
12MP0008260_abnormal_autophagy2.34627701
13MP0002452_abnormal_antigen_presenting2.29432381
14MP0001800_abnormal_humoral_immune2.27750768
15MP0003300_gastrointestinal_ulcer2.25461766
16MP0005451_abnormal_body_composition2.21936172
17MP0005025_abnormal_response_to2.13415117
18MP0009278_abnormal_bone_marrow2.03996614
19MP0002166_altered_tumor_susceptibility2.03866888
20MP0002723_abnormal_immune_serum2.03785315
21MP0005671_abnormal_response_to2.02734540
22MP0003566_abnormal_cell_adhesion1.99407205
23MP0001819_abnormal_immune_cell1.97311332
24MP0010352_gastrointestinal_tract_polyps1.96551910
25MP0002420_abnormal_adaptive_immunity1.96434234
26MP0005058_abnormal_lysosome_morphology1.92109759
27MP0002405_respiratory_system_inflammati1.86671479
28MP0004947_skin_inflammation1.86636757
29MP0003724_increased_susceptibility_to1.80613035
30MP0002006_tumorigenesis1.80522837
31MP0002877_abnormal_melanocyte_morpholog1.75826399
32MP0004510_myositis1.75560778
33MP0005076_abnormal_cell_differentiation1.72079058
34MP0006082_CNS_inflammation1.68207419
35MP0001533_abnormal_skeleton_physiology1.67089821
36MP0005464_abnormal_platelet_physiology1.66489472
37MP0008438_abnormal_cutaneous_collagen1.60727509
38MP0010155_abnormal_intestine_physiology1.60161495
39MP0001545_abnormal_hematopoietic_system1.57278775
40MP0005397_hematopoietic_system_phenotyp1.57278775
41MP0002398_abnormal_bone_marrow1.55044120
42MP0001853_heart_inflammation1.54401429
43* MP0003448_altered_tumor_morphology1.54089928
44MP0000716_abnormal_immune_system1.50653515
45MP0010307_abnormal_tumor_latency1.50633826
46MP0000858_altered_metastatic_potential1.48446794
47MP0001845_abnormal_inflammatory_respons1.44584240
48MP0003705_abnormal_hypodermis_morpholog1.43402339
49MP0001958_emphysema1.41281643
50MP0003172_abnormal_lysosome_physiology1.40093102
51MP0003763_abnormal_thymus_physiology1.39951050
52MP0005164_abnormal_response_to1.37345841
53MP0005174_abnormal_tail_pigmentation1.36499345
54MP0004883_abnormal_blood_vessel1.36490923
55MP0004808_abnormal_hematopoietic_stem1.35498511
56MP0005409_darkened_coat_color1.33657098
57MP0002933_joint_inflammation1.33506969
58MP0004381_abnormal_hair_follicle1.32883402
59MP0003091_abnormal_cell_migration1.32844885
60MP0002396_abnormal_hematopoietic_system1.32100862
61MP0000689_abnormal_spleen_morphology1.30146872
62MP0008057_abnormal_DNA_replication1.29663526
63MP0002796_impaired_skin_barrier1.25444897
64MP0005023_abnormal_wound_healing1.24084204
65MP0002429_abnormal_blood_cell1.23657920
66MP0002722_abnormal_immune_system1.23618423
67MP0001873_stomach_inflammation1.23152963
68MP0003183_abnormal_peptide_metabolism1.22278173
69MP0005310_abnormal_salivary_gland1.21325699
70MP0002998_abnormal_bone_remodeling1.18478872
71MP0003279_aneurysm1.17523095
72MP0009333_abnormal_splenocyte_physiolog1.16425666
73MP0002254_reproductive_system_inflammat1.14967802
74MP0003453_abnormal_keratinocyte_physiol1.13834933
75MP0000343_altered_response_to1.13578083
76MP0004782_abnormal_surfactant_physiolog1.11816066
77MP0000465_gastrointestinal_hemorrhage1.11158631
78MP0005275_abnormal_skin_tensile1.10997654
79MP0004264_abnormal_extraembryonic_tissu1.10037038
80MP0003656_abnormal_erythrocyte_physiolo1.09814887
81MP0006054_spinal_hemorrhage1.09570235
82MP0003828_pulmonary_edema1.09515580
83MP0000371_diluted_coat_color1.07512853
84MP0003191_abnormal_cellular_cholesterol1.03846418
85MP0003950_abnormal_plasma_membrane1.01922897
86MP0005257_abnormal_intraocular_pressure1.01857218
87MP0005390_skeleton_phenotype1.00826519
88MP0000490_abnormal_crypts_of1.00194841
89MP0010678_abnormal_skin_adnexa0.99088045
90MP0002138_abnormal_hepatobiliary_system0.98315791
91MP0008469_abnormal_protein_level0.98277977
92MP0000767_abnormal_smooth_muscle0.96503518
93MP0002060_abnormal_skin_morphology0.95870850
94MP0000703_abnormal_thymus_morphology0.95434622
95MP0004272_abnormal_basement_membrane0.94668428
96MP0001849_ear_inflammation0.90759250
97MP0001851_eye_inflammation0.90319036
98MP0008004_abnormal_stomach_pH0.89305383
99MP0003075_altered_response_to0.88783864
100MP0004233_abnormal_muscle_weight0.88346841
101MP0009764_decreased_sensitivity_to0.86888382
102MP0002277_abnormal_respiratory_mucosa0.85175506
103MP0001879_abnormal_lymphatic_vessel0.84128201
104MP0000015_abnormal_ear_pigmentation0.83603082
105MP0003045_fibrosis0.80405344
106MP0001243_abnormal_dermal_layer0.80256697
107MP0005408_hypopigmentation0.80028426
108MP0003221_abnormal_cardiomyocyte_apopto0.79912793
109MP0002009_preneoplasia0.79101801
110MP0003795_abnormal_bone_structure0.78915900
111MP0005166_decreased_susceptibility_to0.78544884
112MP0004185_abnormal_adipocyte_glucose0.77999800
113MP0003866_abnormal_defecation0.77275664
114MP0010234_abnormal_vibrissa_follicle0.75599932
115MP0001216_abnormal_epidermal_layer0.71373336
116MP0000733_abnormal_muscle_development0.70670330
117MP0000249_abnormal_blood_vessel0.70157312
118MP0005621_abnormal_cell_physiology0.67001799
119MP0001915_intracranial_hemorrhage0.66695879
120MP0008007_abnormal_cellular_replicative0.66632388
121MP0001191_abnormal_skin_condition0.66031426

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.38523340
2Eczematoid dermatitis (HP:0000976)4.99227311
3Recurrent bacterial skin infections (HP:0005406)4.84835357
4Recurrent fungal infections (HP:0002841)3.49977969
5Abnormality of macrophages (HP:0004311)3.45180715
6Myositis (HP:0100614)3.42256465
7Mediastinal lymphadenopathy (HP:0100721)3.32524487
8Recurrent gram-negative bacterial infections (HP:0005420)3.31130861
9Autoimmune thrombocytopenia (HP:0001973)3.27022340
10Elevated erythrocyte sedimentation rate (HP:0003565)3.23788677
11Orchitis (HP:0100796)3.17698301
12Recurrent viral infections (HP:0004429)3.14821722
13Gingivitis (HP:0000230)3.13803988
14Periodontitis (HP:0000704)3.07120498
15Subacute progressive viral hepatitis (HP:0006572)3.06105699
16Interstitial pulmonary disease (HP:0006530)3.04219575
17Retrobulbar optic neuritis (HP:0100654)3.03618916
18Optic neuritis (HP:0100653)3.03618916
19Recurrent skin infections (HP:0001581)3.00361148
20Cellulitis (HP:0100658)2.96479109
21Hematochezia (HP:0002573)2.95726651
22Osteolytic defects of the hand bones (HP:0009699)2.91571219
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.91571219
24Vacuolated lymphocytes (HP:0001922)2.90565352
25Peritonitis (HP:0002586)2.74721898
26Stomatitis (HP:0010280)2.73987296
27Pustule (HP:0200039)2.70462445
28Vasculitis (HP:0002633)2.68935919
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67760509
30Increased cerebral lipofuscin (HP:0011813)2.65451823
31Osteomyelitis (HP:0002754)2.61378330
32Thick nail (HP:0001805)2.58286401
33Chronic obstructive pulmonary disease (HP:0006510)2.56680989
34Obstructive lung disease (HP:0006536)2.56680989
35Chronic mucocutaneous candidiasis (HP:0002728)2.55942699
36Recurrent cutaneous fungal infections (HP:0011370)2.55942699
37Absent frontal sinuses (HP:0002688)2.48380008
38Milia (HP:0001056)2.46637454
39Spontaneous hematomas (HP:0007420)2.43367544
40Prostate neoplasm (HP:0100787)2.40134704
41Pulmonary infiltrates (HP:0002113)2.39995730
42Gastrointestinal infarctions (HP:0005244)2.38021044
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.36742523
44Arterial tortuosity (HP:0005116)2.34614939
45Premature rupture of membranes (HP:0001788)2.31439733
46Arterial thrombosis (HP:0004420)2.31207153
47Meningitis (HP:0001287)2.31150673
48Leukocytosis (HP:0001974)2.30242444
49Myocardial infarction (HP:0001658)2.27858357
50Dilatation of the ascending aorta (HP:0005111)2.23853341
51Colitis (HP:0002583)2.21987077
52Chronic otitis media (HP:0000389)2.21805573
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.21676103
54Abnormality of the fingertips (HP:0001211)2.21296717
55Recurrent pneumonia (HP:0006532)2.19331785
56Vascular tortuosity (HP:0004948)2.19253575
57Eosinophilia (HP:0001880)2.16789070
58Inflammation of the large intestine (HP:0002037)2.13254838
59Viral hepatitis (HP:0006562)2.11931779
60Abnormality of T cell number (HP:0011839)2.08967143
61Atrophic scars (HP:0001075)2.07745251
62Abnormality of oral frenula (HP:0000190)2.05275574
63Increased IgE level (HP:0003212)2.04227073
64Aortic dissection (HP:0002647)2.04148581
65Syringomyelia (HP:0003396)2.04088950
66Spinal cord lesions (HP:0100561)2.04088950
67Cervical subluxation (HP:0003308)2.03319777
68Protrusio acetabuli (HP:0003179)2.02455469
69Recurrent lower respiratory tract infections (HP:0002783)2.00123437
70Premature loss of primary teeth (HP:0006323)1.99913756
71Agammaglobulinemia (HP:0004432)1.99624183
72Gastrointestinal inflammation (HP:0004386)1.98686672
73Skin ulcer (HP:0200042)1.96175176
74Recurrent bronchitis (HP:0002837)1.96037908
75Basal ganglia calcification (HP:0002135)1.95872880
76Cerebral aneurysm (HP:0004944)1.95600113
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94781610
78T lymphocytopenia (HP:0005403)1.94662949
79Amyloidosis (HP:0011034)1.93731576
80Keratoconjunctivitis sicca (HP:0001097)1.93160961
81Micronodular cirrhosis (HP:0001413)1.92733762
82Chest pain (HP:0100749)1.90696893
83Hemoptysis (HP:0002105)1.89671953
84Ankyloglossia (HP:0010296)1.88716769
85Fatigue (HP:0012378)1.88412114
86Disinhibition (HP:0000734)1.86870323
87Abnormality of the distal phalanges of the toes (HP:0010182)1.86311227
88Vertebral compression fractures (HP:0002953)1.85631455
89Thyroiditis (HP:0100646)1.85570919
90Persistence of primary teeth (HP:0006335)1.85544742
91Broad face (HP:0000283)1.85381989
92Short nail (HP:0001799)1.84913646
93Emphysema (HP:0002097)1.84190702
94Keratoconjunctivitis (HP:0001096)1.82783859
95Restrictive lung disease (HP:0002091)1.82559324
96Granulocytopenia (HP:0001913)1.82125255
97IgM deficiency (HP:0002850)1.82109775
98Mitral stenosis (HP:0001718)1.81158491
99Loss of speech (HP:0002371)1.80996914
100Ulnar bowing (HP:0003031)1.80212669
101Cheilitis (HP:0100825)1.79838239
102Abnormality of the frontal sinuses (HP:0002687)1.79356846
103Increased connective tissue (HP:0009025)1.78475406
104Urticaria (HP:0001025)1.77855126
105Abnormality of the peritoneum (HP:0002585)1.77208105
106Sepsis (HP:0100806)1.77143715
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76199921
108Flat acetabular roof (HP:0003180)1.74618745
109Coarse hair (HP:0002208)1.74303420
110Slow saccadic eye movements (HP:0000514)1.72647459
111Dysostosis multiplex (HP:0000943)1.72613090
112Abnormality of T cells (HP:0002843)1.72112269
113IgA deficiency (HP:0002720)1.71993508
114Thrombocytosis (HP:0001894)1.71641389
115Abnormality of liposaccharide metabolism (HP:0010968)1.71060092
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.71060092
117Abnormality of glycolipid metabolism (HP:0010969)1.71060092
118Wormian bones (HP:0002645)1.70819122
119Thin bony cortex (HP:0002753)1.69632456
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69513854
121Abnormal platelet volume (HP:0011876)1.67767184
122Autoimmune hemolytic anemia (HP:0001890)1.67587947
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.67404571
124Gingival bleeding (HP:0000225)1.66897630
125Increased density of long bones (HP:0006392)1.65872618
126Aneurysm (HP:0002617)1.65495296
127Spondylolisthesis (HP:0003302)1.65433746
128Epistaxis (HP:0000421)1.64931698
129Mitral valve prolapse (HP:0001634)1.64454146
130Lymphopenia (HP:0001888)1.64335722
131Urinary glycosaminoglycan excretion (HP:0003541)1.63257474
132Mucopolysacchariduria (HP:0008155)1.63257474
133Aortic aneurysm (HP:0004942)1.62762908
134Bone pain (HP:0002653)1.62657457
135Abnormality of eosinophils (HP:0001879)1.61322809
136Hypergammaglobulinemia (HP:0010702)1.60626763
137Abnormality of T cell physiology (HP:0011840)1.60619012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.76082307
2MAP4K13.02498053
3IRAK42.52841201
4TYK22.49315855
5PRPF4B2.48058017
6TBK12.37323783
7IRAK32.35229100
8JAK32.34086327
9STK102.14200315
10IKBKB2.01429596
11BLK1.98467619
12RIPK41.98095137
13IKBKE1.97565990
14TTN1.95724711
15KIT1.94669618
16MST1R1.93575837
17JAK11.88388159
18CDK121.84218562
19MAP3K21.77795036
20CHUK1.73986244
21ERN11.71464763
22TRPM71.69057428
23TXK1.65424882
24ZAP701.62616188
25MAP3K31.58833260
26TGFBR21.57904433
27MAP3K101.46923125
28CSK1.46639829
29MST41.46608244
30KSR21.43667207
31EPHB11.43504243
32TAOK31.42498617
33RPS6KA41.40374903
34BTK1.39396281
35MAP2K31.39359005
36PIM11.38191575
37PTK61.37899027
38FGFR31.35616334
39LRRK21.35118212
40RIPK11.31065317
41TEC1.30172273
42HCK1.28325712
43MAP3K11.24311407
44MAP3K61.23881743
45NEK91.21262450
46PDGFRA1.20873646
47ITK1.17449849
48SMG11.17364407
49CSF1R1.14360109
50SYK1.12987495
51PIM21.12811606
52TRIB31.12211409
53CDK61.09660896
54LCK1.03694608
55STK241.03461012
56MOS1.03084211
57STK31.00984198
58MAP3K130.99625334
59STK40.97956986
60PIK3CG0.96382189
61MARK30.93304680
62FGFR40.91338247
63PKN20.90998131
64EPHA30.90377406
65ERBB30.90346568
66EPHA20.88772486
67CDC42BPA0.87967333
68WNK10.87449622
69KSR10.85665152
70MET0.82396406
71CAMK1D0.82062490
72SGK30.81756535
73CLK10.81130409
74LYN0.81110472
75PAK40.80981562
76NUAK10.80938729
77JAK20.78467447
78GRK60.76257752
79IRAK10.72405680
80SIK30.72386229
81RAF10.71409560
82BMX0.69874627
83NEK60.69760814
84ICK0.69685603
85PDGFRB0.67022922
86FRK0.66817827
87TESK10.66791026
88SIK10.66115852
89FLT30.64593411
90PDPK10.64522688
91CAMKK20.64326938
92STK380.62600104
93ABL10.60347363
94NLK0.60195831
95MAPKAPK20.58087530
96NME20.57440541
97PDK10.57245902
98EGFR0.56912459
99RET0.56623128
100IRAK20.56175376
101EIF2AK20.55611635
102BRD40.54675864
103MTOR0.54580020
104PTK2B0.53436136
105EEF2K0.53184655
106MATK0.52830026
107MAP3K80.52259705
108TAOK20.51841792
109MARK20.50635164
110LATS10.50504315
111NEK20.49158461
112RPS6KA60.48156107
113SCYL20.47973722
114CDK40.47395193
115ZAK0.46536074
116PRKG20.46194321
117FER0.45694161
118HIPK20.45195563
119SIK20.44637049
120YES10.43545858
121FGR0.41084313
122PRKCD0.40598211
123BMPR20.39774401
124TGFBR10.38916244
125RPS6KL10.38892432
126RPS6KC10.38892432
127PTK20.37994240
128RPS6KB20.37676554
129PRKCQ0.37315551
130DYRK1B0.36908854
131CAMK1G0.36381193
132MELK0.36176483
133FES0.34869574

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.70362750
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.48991034
3Osteoclast differentiation_Homo sapiens_hsa043802.17175607
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05612223
5Measles_Homo sapiens_hsa051621.98357083
6B cell receptor signaling pathway_Homo sapiens_hsa046621.97045819
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90086683
8Graft-versus-host disease_Homo sapiens_hsa053321.82292137
9Allograft rejection_Homo sapiens_hsa053301.80432754
10Malaria_Homo sapiens_hsa051441.79297778
11Legionellosis_Homo sapiens_hsa051341.79265885
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.79105612
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78146430
14Toxoplasmosis_Homo sapiens_hsa051451.73822827
15Antigen processing and presentation_Homo sapiens_hsa046121.73288599
16Primary immunodeficiency_Homo sapiens_hsa053401.70478879
17Tuberculosis_Homo sapiens_hsa051521.69821287
18Pertussis_Homo sapiens_hsa051331.67451199
19TNF signaling pathway_Homo sapiens_hsa046681.66308870
20Influenza A_Homo sapiens_hsa051641.63170574
21Hematopoietic cell lineage_Homo sapiens_hsa046401.61983485
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60532166
23Apoptosis_Homo sapiens_hsa042101.59646456
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.50193449
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48509739
26Shigellosis_Homo sapiens_hsa051311.47891952
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45617239
28Viral myocarditis_Homo sapiens_hsa054161.44126710
29Lysosome_Homo sapiens_hsa041421.43672677
30Herpes simplex infection_Homo sapiens_hsa051681.42126785
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40716895
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.37793090
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36130356
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35649456
35Renal cell carcinoma_Homo sapiens_hsa052111.32976859
36Chronic myeloid leukemia_Homo sapiens_hsa052201.31273774
37Small cell lung cancer_Homo sapiens_hsa052221.30243326
38Salmonella infection_Homo sapiens_hsa051321.28806730
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26871432
40Hepatitis B_Homo sapiens_hsa051611.26186144
41Asthma_Homo sapiens_hsa053101.25501397
42Phagosome_Homo sapiens_hsa041451.23139555
43Rheumatoid arthritis_Homo sapiens_hsa053231.23024609
44Thyroid cancer_Homo sapiens_hsa052161.22975620
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21356395
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.19663222
47Chemokine signaling pathway_Homo sapiens_hsa040621.19313061
48Other glycan degradation_Homo sapiens_hsa005111.18536579
49T cell receptor signaling pathway_Homo sapiens_hsa046601.16870250
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14819360
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11986339
52Acute myeloid leukemia_Homo sapiens_hsa052211.10919945
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10066721
54Pancreatic cancer_Homo sapiens_hsa052121.06961657
55Hepatitis C_Homo sapiens_hsa051601.05981201
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05546730
57Autoimmune thyroid disease_Homo sapiens_hsa053201.02537212
58Dorso-ventral axis formation_Homo sapiens_hsa043201.01900972
59MicroRNAs in cancer_Homo sapiens_hsa052060.98553408
60Amoebiasis_Homo sapiens_hsa051460.96959704
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94889245
62Platelet activation_Homo sapiens_hsa046110.91921509
63Viral carcinogenesis_Homo sapiens_hsa052030.90869859
64ECM-receptor interaction_Homo sapiens_hsa045120.90328527
65Focal adhesion_Homo sapiens_hsa045100.89512844
66p53 signaling pathway_Homo sapiens_hsa041150.88692670
67* Proteoglycans in cancer_Homo sapiens_hsa052050.87360650
68Epstein-Barr virus infection_Homo sapiens_hsa051690.86688595
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86588843
70Type I diabetes mellitus_Homo sapiens_hsa049400.85807977
71HTLV-I infection_Homo sapiens_hsa051660.85146807
72Glioma_Homo sapiens_hsa052140.82324506
73ErbB signaling pathway_Homo sapiens_hsa040120.78475369
74* Adherens junction_Homo sapiens_hsa045200.78330860
75Prolactin signaling pathway_Homo sapiens_hsa049170.77637409
76* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75709959
77African trypanosomiasis_Homo sapiens_hsa051430.74870241
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74061881
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.73859751
80Caffeine metabolism_Homo sapiens_hsa002320.70981986
81GnRH signaling pathway_Homo sapiens_hsa049120.70374649
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.70194937
83Prostate cancer_Homo sapiens_hsa052150.69834260
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68480648
85Notch signaling pathway_Homo sapiens_hsa043300.67477606
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.66928504
87Estrogen signaling pathway_Homo sapiens_hsa049150.62940927
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60991351
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60628395
90Choline metabolism in cancer_Homo sapiens_hsa052310.60202442
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54699192
92HIF-1 signaling pathway_Homo sapiens_hsa040660.54047579
93FoxO signaling pathway_Homo sapiens_hsa040680.53597240
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52694181
95Non-small cell lung cancer_Homo sapiens_hsa052230.51961504
96VEGF signaling pathway_Homo sapiens_hsa043700.49796174
97Non-homologous end-joining_Homo sapiens_hsa034500.49677765
98Pathways in cancer_Homo sapiens_hsa052000.49226805
99Insulin resistance_Homo sapiens_hsa049310.48242375
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48150177
101Colorectal cancer_Homo sapiens_hsa052100.47275649
102Renin-angiotensin system_Homo sapiens_hsa046140.46267386
103Endocytosis_Homo sapiens_hsa041440.45986996
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44524287
105Bladder cancer_Homo sapiens_hsa052190.44497031
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.44134780
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43524457
108Endometrial cancer_Homo sapiens_hsa052130.41473363
109mTOR signaling pathway_Homo sapiens_hsa041500.41034326
110Sphingolipid metabolism_Homo sapiens_hsa006000.39567543
111TGF-beta signaling pathway_Homo sapiens_hsa043500.38470607
112Inositol phosphate metabolism_Homo sapiens_hsa005620.37142587
113Melanoma_Homo sapiens_hsa052180.36976402
114Base excision repair_Homo sapiens_hsa034100.35936465
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.35863975

Most similar genes based on co-expression Upload to Enrichr

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