IQCF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.97762508
2cell-cell recognition (GO:0009988)9.87709777
3plasma membrane fusion (GO:0045026)9.69303271
4reproduction (GO:0000003)9.42026308
5spermatid development (GO:0007286)8.88081300
6axonemal dynein complex assembly (GO:0070286)8.77244909
7epithelial cilium movement (GO:0003351)8.62061074
8motile cilium assembly (GO:0044458)8.31378438
9cilium or flagellum-dependent cell motility (GO:0001539)7.79136707
10regulation of cilium movement (GO:0003352)7.68266952
11male meiosis (GO:0007140)7.66390579
12piRNA metabolic process (GO:0034587)7.50986986
13synaptonemal complex assembly (GO:0007130)7.29501232
14single fertilization (GO:0007338)7.23430330
15synaptonemal complex organization (GO:0070193)7.18447086
16cilium movement (GO:0003341)7.00951851
17microtubule depolymerization (GO:0007019)6.56425586
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.51482497
19spermatogenesis (GO:0007283)6.46471079
20male gamete generation (GO:0048232)6.44501172
21sperm capacitation (GO:0048240)6.42934702
22negative regulation of inclusion body assembly (GO:0090084)6.27197002
23fertilization (GO:0009566)6.15914528
24gamete generation (GO:0007276)6.05189457
25organic cation transport (GO:0015695)5.42758428
26chromosome condensation (GO:0030261)5.42313081
27microtubule severing (GO:0051013)5.38581691
28spermatid nucleus differentiation (GO:0007289)5.36613127
29regulation of inclusion body assembly (GO:0090083)5.24341054
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.13821829
31germ cell development (GO:0007281)5.05603762
32DNA packaging (GO:0006323)5.02955439
33chromosome organization involved in meiosis (GO:0070192)4.98593631
34DNA methylation involved in gamete generation (GO:0043046)4.96611980
35calcium ion-dependent exocytosis (GO:0017156)4.89916480
36male meiosis I (GO:0007141)4.84032122
37multicellular organismal reproductive process (GO:0048609)4.74230497
38cell recognition (GO:0008037)4.72480815
39meiotic nuclear division (GO:0007126)4.62268741
40glycerol ether metabolic process (GO:0006662)4.59307150
41monoubiquitinated protein deubiquitination (GO:0035520)4.40172549
42single strand break repair (GO:0000012)4.38712840
43regulation of microtubule-based movement (GO:0060632)4.36664238
44ventricular system development (GO:0021591)4.29441331
45ether metabolic process (GO:0018904)4.23303859
46meiosis I (GO:0007127)4.19607673
47meiotic cell cycle (GO:0051321)3.96066022
48seminiferous tubule development (GO:0072520)3.89249732
49sexual reproduction (GO:0019953)3.81506353
50chaperone-mediated protein complex assembly (GO:0051131)3.76348746
51multicellular organismal development (GO:0007275)3.69413261
52protein polyglutamylation (GO:0018095)3.67722499
53regulation of spindle checkpoint (GO:0090231)3.65401161
54microtubule polymerization or depolymerization (GO:0031109)3.58458569
55protein K11-linked deubiquitination (GO:0035871)3.41428878
56meiotic cell cycle process (GO:1903046)3.41069307
57mitotic sister chromatid cohesion (GO:0007064)3.33308656
58sequestering of actin monomers (GO:0042989)3.13688943
59left/right pattern formation (GO:0060972)3.13009743
60protein localization to chromosome, centromeric region (GO:0071459)3.09102979
61nucleus organization (GO:0006997)3.07031874
62histone exchange (GO:0043486)2.96234144
63genitalia morphogenesis (GO:0035112)2.93403713
64gene silencing by RNA (GO:0031047)2.89446694
65glycolytic process (GO:0006096)2.83324035
66synapsis (GO:0007129)2.82218530
67centriole assembly (GO:0098534)2.81954134
68polyol catabolic process (GO:0046174)2.76572251
69nucleoside diphosphate phosphorylation (GO:0006165)2.73391658
70protein refolding (GO:0042026)2.72092492
71polyamine biosynthetic process (GO:0006596)2.71759986
72regulation of meiosis I (GO:0060631)2.67663993
73cilium morphogenesis (GO:0060271)2.66447839
74interferon-gamma secretion (GO:0072643)2.65938927
75protein complex localization (GO:0031503)2.65479671
76positive regulation of macrophage activation (GO:0043032)2.65143447
77chromatin silencing (GO:0006342)2.62133906
78centriole replication (GO:0007099)2.61936985
79GTP biosynthetic process (GO:0006183)2.61651028
80cilium organization (GO:0044782)2.60244000
81gene silencing (GO:0016458)2.57963967
82alditol metabolic process (GO:0019400)2.56302507
83amino-acid betaine transport (GO:0015838)2.55700761
84carnitine transport (GO:0015879)2.55700761
85sister chromatid cohesion (GO:0007062)2.55350570
86regulation of cilium assembly (GO:1902017)2.52334191
87cilium assembly (GO:0042384)2.51615321
88cellular component assembly involved in morphogenesis (GO:0010927)2.51101638
89regulation of centriole replication (GO:0046599)2.49216584
90lactate metabolic process (GO:0006089)2.44235096
91microtubule-based movement (GO:0007018)2.42534738
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.39459934
93cell wall macromolecule metabolic process (GO:0044036)13.4068328
94cell wall macromolecule catabolic process (GO:0016998)13.4068328
95fusion of sperm to egg plasma membrane (GO:0007342)12.7577335
96sperm motility (GO:0030317)12.2791183
97acrosome assembly (GO:0001675)11.5571884
98sperm-egg recognition (GO:0035036)11.0668597
99multicellular organism reproduction (GO:0032504)11.0217486
100acrosome reaction (GO:0007340)10.6453233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.08142944
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.83970835
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21850415
4EZH2_22144423_ChIP-Seq_EOC_Human3.14298835
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71919279
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60331602
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.51799084
8KAP1_22055183_ChIP-Seq_ESCs_Mouse2.42881034
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.41272406
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.37897727
11VDR_22108803_ChIP-Seq_LS180_Human2.34182093
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33187058
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14822383
14KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.13362580
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10183198
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05560204
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03894208
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00741933
19STAT1_17558387_ChIP-Seq_HELA_Human1.88081455
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85774270
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.80468302
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.77606091
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.73564662
24GATA3_21867929_ChIP-Seq_CD8_Mouse1.72496600
25* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70907971
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62909352
27ZNF274_21170338_ChIP-Seq_K562_Hela1.61400880
28SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60185811
29GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56362134
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.56289696
31KDM2B_26808549_Chip-Seq_REH_Human1.54806370
32TAL1_26923725_Chip-Seq_HPCs_Mouse1.50907368
33RUNX1_26923725_Chip-Seq_HPCs_Mouse1.47927572
34GATA3_21867929_ChIP-Seq_TH1_Mouse1.47478271
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.46003178
36FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38714209
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.37946971
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34914645
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32176892
40FLI1_21867929_ChIP-Seq_TH2_Mouse1.31897554
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.30905947
42CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30586911
43LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29483764
44SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28617326
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26435268
46GF1_26923725_Chip-Seq_HPCs_Mouse1.26344554
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.25764673
48P53_21459846_ChIP-Seq_SAOS-2_Human1.25277937
49CBP_20019798_ChIP-Seq_JUKART_Human1.24937112
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24937112
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24930036
52RNF2_27304074_Chip-Seq_NSC_Mouse1.24144567
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21100498
54SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20963339
55CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18707086
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18107053
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17675866
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.17142067
59* SPI1_26923725_Chip-Seq_HPCs_Mouse1.16650684
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15219688
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11296120
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.11092116
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10350873
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10350873
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09981917
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09041326
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08210289
68ESET_19884257_ChIP-Seq_ESCs_Mouse1.07996844
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.07979044
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.07750297
71ERG_20517297_ChIP-Seq_VCAP_Human1.07631174
72P53_22387025_ChIP-Seq_ESCs_Mouse1.06656026
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05253107
74LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03757884
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03578022
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02838650
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01447395
78GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01212759
79GF1B_26923725_Chip-Seq_HPCs_Mouse1.00524712
80RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00275061
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00175078
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.00011180
83REST_21632747_ChIP-Seq_MESCs_Mouse0.99817907
84RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98585619
85STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97895870
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97148422
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96961289
88SOX2_18555785_Chip-Seq_ESCs_Mouse0.96714680
89FLI1_21867929_ChIP-Seq_CD8_Mouse0.96645498
90P300_18555785_Chip-Seq_ESCs_Mouse0.96239565
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95274581
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.93815902
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93359489
94NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92470000
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.92265058
96MYC_27129775_Chip-Seq_CORNEA_Mouse0.92126845
97CTCF_18555785_Chip-Seq_ESCs_Mouse0.91076767
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90700705
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90655619
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90345799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.69741286
2MP0001929_abnormal_gametogenesis5.67024058
3MP0008877_abnormal_DNA_methylation4.78701776
4MP0002210_abnormal_sex_determination3.63192112
5MP0002161_abnormal_fertility/fecundity3.36822580
6MP0002653_abnormal_ependyma_morphology3.06838740
7MP0001145_abnormal_male_reproductive3.05127338
8MP0000653_abnormal_sex_gland2.85520449
9MP0003646_muscle_fatigue2.48812053
10MP0005670_abnormal_white_adipose2.43617716
11MP0005410_abnormal_fertilization14.5955863
12MP0002102_abnormal_ear_morphology1.88564813
13MP0010094_abnormal_chromosome_stability1.57130599
14MP0008058_abnormal_DNA_repair1.53600397
15MP0003693_abnormal_embryo_hatching1.47342209
16MP0003718_maternal_effect1.46092105
17MP0004233_abnormal_muscle_weight1.45906363
18MP0002160_abnormal_reproductive_system1.40914744
19MP0003111_abnormal_nucleus_morphology1.38791395
20MP0002282_abnormal_trachea_morphology1.21465747
21MP0005451_abnormal_body_composition1.20232463
22MP0003699_abnormal_female_reproductive1.18069213
23MP0008057_abnormal_DNA_replication1.12760039
24MP0003077_abnormal_cell_cycle1.09256933
25MP0001119_abnormal_female_reproductive1.02472694
26MP0001529_abnormal_vocalization1.01909450
27MP0001984_abnormal_olfaction1.01501954
28MP0004957_abnormal_blastocyst_morpholog0.96730898
29MP0002736_abnormal_nociception_after0.93277069
30MP0005389_reproductive_system_phenotype0.93250796
31MP0005623_abnormal_meninges_morphology0.90893793
32MP0001730_embryonic_growth_arrest0.88602834
33MP0002234_abnormal_pharynx_morphology0.88222450
34MP0005647_abnormal_sex_gland0.88202711
35MP0001765_abnormal_ion_homeostasis0.86979924
36MP0008007_abnormal_cellular_replicative0.85044762
37MP0003787_abnormal_imprinting0.72605099
38MP0000569_abnormal_digit_pigmentation0.69326449
39MP0008995_early_reproductive_senescence0.66992812
40MP0005395_other_phenotype0.66739066
41MP0008932_abnormal_embryonic_tissue0.63807132
42MP0005408_hypopigmentation0.61677207
43MP0003115_abnormal_respiratory_system0.59809258
44MP0001697_abnormal_embryo_size0.59001509
45MP0002085_abnormal_embryonic_tissue0.57187078
46MP0002084_abnormal_developmental_patter0.56406685
47MP0003890_abnormal_embryonic-extraembry0.56295675
48MP0004036_abnormal_muscle_relaxation0.54996609
49MP0001672_abnormal_embryogenesis/_devel0.54354562
50MP0005380_embryogenesis_phenotype0.54354562
51MP0009046_muscle_twitch0.53510355
52MP0003315_abnormal_perineum_morphology0.53063469
53MP0005636_abnormal_mineral_homeostasis0.52047576
54MP0001968_abnormal_touch/_nociception0.49811844
55MP0003861_abnormal_nervous_system0.49205674
56MP0003123_paternal_imprinting0.49077240
57MP0004133_heterotaxia0.48056809
58MP0003786_premature_aging0.47425901
59MP0000462_abnormal_digestive_system0.47058290
60MP0010307_abnormal_tumor_latency0.45463102
61MP0003984_embryonic_growth_retardation0.44423777
62MP0002269_muscular_atrophy0.44135529
63MP0004145_abnormal_muscle_electrophysio0.43534786
64MP0003329_amyloid_beta_deposits0.43534277
65MP0000534_abnormal_ureter_morphology0.42966948
66MP0002088_abnormal_embryonic_growth/wei0.40803680
67MP0000358_abnormal_cell_content/0.40437743
68MP0001293_anophthalmia0.39933545
69MP0001849_ear_inflammation0.39917439
70MP0001764_abnormal_homeostasis0.38534120
71MP0005646_abnormal_pituitary_gland0.38155854
72MP0000313_abnormal_cell_death0.38071929
73MP0004084_abnormal_cardiac_muscle0.36973326
74MP0005666_abnormal_adipose_tissue0.36458527
75MP0001919_abnormal_reproductive_system0.36103393
76MP0002080_prenatal_lethality0.35357157
77MP0006036_abnormal_mitochondrial_physio0.35231526
78MP0005397_hematopoietic_system_phenotyp0.35186321
79MP0001545_abnormal_hematopoietic_system0.35186321
80MP0003937_abnormal_limbs/digits/tail_de0.34964269
81MP0000350_abnormal_cell_proliferation0.34683709
82MP0002277_abnormal_respiratory_mucosa0.33299123
83MP0001324_abnormal_eye_pigmentation0.32468228
84MP0000432_abnormal_head_morphology0.31958296
85MP0003011_delayed_dark_adaptation0.31480497
86MP0002169_no_abnormal_phenotype0.29643966
87MP0002873_normal_phenotype0.29382978
88MP0009250_abnormal_appendicular_skeleto0.28198256
89MP0003950_abnormal_plasma_membrane0.25831802
90MP0000579_abnormal_nail_morphology0.23911871
91MP0006072_abnormal_retinal_apoptosis0.23325182
92MP0001727_abnormal_embryo_implantation0.23073699
93MP0002152_abnormal_brain_morphology0.22316673
94MP0002249_abnormal_larynx_morphology0.21542995
95MP0003942_abnormal_urinary_system0.21497429
96MP0005551_abnormal_eye_electrophysiolog0.21018528
97MP0000001_mammalian_phenotype0.20388724
98MP0003121_genomic_imprinting0.20270398
99MP0002837_dystrophic_cardiac_calcinosis0.19596614
100MP0005187_abnormal_penis_morphology0.19051587

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34445832
2Abnormal respiratory motile cilium morphology (HP:0005938)8.50083043
3Abnormal respiratory epithelium morphology (HP:0012253)8.50083043
4Chronic bronchitis (HP:0004469)7.68672092
5Rhinitis (HP:0012384)7.37122684
6Abnormal ciliary motility (HP:0012262)7.33862287
7Infertility (HP:0000789)6.93758610
8Male infertility (HP:0003251)6.25740472
9Nasal polyposis (HP:0100582)5.87456129
10Abnormality of the nasal mucosa (HP:0000433)4.74223873
11Bronchiectasis (HP:0002110)4.43724186
12Bronchitis (HP:0012387)4.40587286
13Abnormal spermatogenesis (HP:0008669)4.09973674
14Nephronophthisis (HP:0000090)3.85069758
15Recurrent otitis media (HP:0000403)3.21574095
16Recurrent sinusitis (HP:0011108)3.12678525
17Molar tooth sign on MRI (HP:0002419)2.93148302
18Abnormality of midbrain morphology (HP:0002418)2.93148302
19Medial flaring of the eyebrow (HP:0010747)2.89779733
20Abnormality of the renal medulla (HP:0100957)2.87168298
21Azoospermia (HP:0000027)2.81151887
22Impulsivity (HP:0100710)2.52801013
23Tubular atrophy (HP:0000092)2.29164581
24Recurrent bronchitis (HP:0002837)2.21864082
25Cholecystitis (HP:0001082)2.20524753
26Abnormal gallbladder physiology (HP:0012438)2.20524753
27Tubulointerstitial nephritis (HP:0001970)2.18673135
28Dyschromatopsia (HP:0007641)2.14699799
29Pancreatic fibrosis (HP:0100732)2.05051996
30Tubulointerstitial abnormality (HP:0001969)2.03847887
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3436961
32Dynein arm defect of respiratory motile cilia (HP:0012255)12.3669431
33Absent/shortened dynein arms (HP:0200106)12.3669431
34Congenital primary aphakia (HP:0007707)1.98889087
35Decreased central vision (HP:0007663)1.98139337
36Gait imbalance (HP:0002141)1.97809109
37Congenital hepatic fibrosis (HP:0002612)1.82519412
38Papillary thyroid carcinoma (HP:0002895)1.78371429
39Postaxial foot polydactyly (HP:0001830)1.77967622
40Aplasia/Hypoplasia of the lens (HP:0008063)1.77423233
41Tubulointerstitial fibrosis (HP:0005576)1.75061853
42Type 2 muscle fiber atrophy (HP:0003554)1.73698505
43Nephrogenic diabetes insipidus (HP:0009806)1.69855699
44Congenital malformation of the right heart (HP:0011723)1.69633346
45Double outlet right ventricle (HP:0001719)1.69633346
46Supernumerary spleens (HP:0009799)1.67254358
47Poor coordination (HP:0002370)1.66797485
48Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63300979
49Microglossia (HP:0000171)1.62665957
50Cystic liver disease (HP:0006706)1.57421870
51Genital tract atresia (HP:0001827)1.57202954
52Aplasia/Hypoplasia of the tongue (HP:0010295)1.57062915
53Tongue fasciculations (HP:0001308)1.56606236
54Muscle fiber atrophy (HP:0100295)1.55854849
55Postaxial hand polydactyly (HP:0001162)1.55572316
56Bile duct proliferation (HP:0001408)1.53206707
57Abnormal biliary tract physiology (HP:0012439)1.53206707
58True hermaphroditism (HP:0010459)1.53204681
59Gonadotropin excess (HP:0000837)1.52955301
60Heterotopia (HP:0002282)1.52322288
61Pancreatic cysts (HP:0001737)1.51968722
62Easy fatigability (HP:0003388)1.51488222
63Vaginal atresia (HP:0000148)1.51214886
64Fatigable weakness (HP:0003473)1.50449517
65Abnormality of the neuromuscular junction (HP:0003398)1.50449517
66Abnormal drinking behavior (HP:0030082)1.49560242
67Polydipsia (HP:0001959)1.49560242
68Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.46265235
69Stage 5 chronic kidney disease (HP:0003774)1.45987514
70Bundle branch block (HP:0011710)1.44883421
71Oculomotor apraxia (HP:0000657)1.44510001
72Short ribs (HP:0000773)1.43746149
73Renal dysplasia (HP:0000110)1.40957950
74Facial cleft (HP:0002006)1.40457050
75Muscle fibrillation (HP:0010546)1.40072663
76Abnormality of renal excretion (HP:0011036)1.38491978
77Abnormality of the renal cortex (HP:0011035)1.36942386
78Spastic tetraparesis (HP:0001285)1.36453884
79Abnormality of the dental root (HP:0006486)1.32082614
80Taurodontia (HP:0000679)1.32082614
81Abnormality of permanent molar morphology (HP:0011071)1.32082614
82Choroideremia (HP:0001139)1.30431682
83Decreased muscle mass (HP:0003199)1.30080407
84Absent epiphyses (HP:0010577)1.24363554
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24363554
86Abnormality of lateral ventricle (HP:0030047)1.23982225
87Chronic sinusitis (HP:0011109)1.23379490
88Cleft eyelid (HP:0000625)1.23061340
89Decreased electroretinogram (ERG) amplitude (HP:0000654)1.22965433
90Abnormality of the dental pulp (HP:0006479)1.22481690
91Asymmetric septal hypertrophy (HP:0001670)1.22010198
92Abnormality of saccadic eye movements (HP:0000570)1.20789070
93Abnormality of dentin (HP:0010299)1.19487036
94Abnormality of molar (HP:0011077)1.19231369
95Abnormality of molar morphology (HP:0011070)1.19231369
96Sloping forehead (HP:0000340)1.18443947
97Constricted visual fields (HP:0001133)1.17309249
98Personality changes (HP:0000751)1.17047382
99Fibular hypoplasia (HP:0003038)1.16523884
100Cerebellar dysplasia (HP:0007033)1.15790771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.02420113
2PDK38.02420113
3PDK25.10992380
4TESK14.80391159
5PRKD34.42902317
6ICK3.60995618
7NEK21.94137653
8TYRO31.79659889
9STK381.79228318
10PTK2B1.79218544
11WNK41.68885719
12MUSK1.67552173
13STK391.65403351
14STK38L1.64770044
15PLK41.61544345
16TTK1.56988733
17EEF2K1.51136616
18CHEK21.22664756
19BRAF1.17185195
20LATS11.15372415
21PDK11.14693433
22DYRK31.10310444
23MAP3K61.06554421
24STK31.05278151
25CDC71.03148983
26PNCK1.03009751
27LATS20.96863042
28DYRK1B0.92373789
29NTRK20.89242620
30ERBB40.88748881
31MELK0.86692283
32BRSK10.80554379
33WEE10.74598274
34PDPK10.71679541
35PLK10.68008338
36BRSK20.67658195
37CCNB10.67073693
38TESK20.60243982
39CHEK10.60076228
40KSR20.54986411
41PASK0.53137316
42MAP2K60.51111550
43MAPKAPK50.48245073
44AURKA0.46708955
45MAP3K50.45773745
46IRAK10.44267473
47MAP3K90.43975079
48PAK10.42754283
49PINK10.41720819
50CDK120.41045136
51STK100.39723173
52DYRK20.39675874
53TAOK10.37767895
54BUB10.37613823
55ATM0.37611811
56ARAF0.35736555
57AURKB0.35013720
58ATR0.34669809
59WNK10.33708449
60LMTK20.32465041
61FGFR20.32034198
62NEK60.31909189
63PRKAA10.29546333
64EIF2AK10.27600385
65CDK150.27452286
66CDK180.26263992
67MAPK150.26004489
68MAP2K70.24561506
69PAK60.24322525
70MAP3K40.24050284
71MAP3K80.23824152
72CDK40.21783401
73MAPKAPK30.21577938
74CDK11A0.21525301
75CDK90.21373709
76MARK20.20723372
77ACVR1B0.20354019
78RAF10.20136746
79RIPK40.20050763
80CDK30.18635382
81PRKCZ0.17274484
82PLK30.16616785
83PRKCG0.16477024
84CDK10.14968774
85MARK30.14780937
86RPS6KB10.14548811
87CDK20.13959399
88CDK140.13336089
89SRPK10.13001366
90RET0.11603910
91MTOR0.11433129
92RPS6KA10.11097424
93MOS0.09888348
94PDGFRB0.09344848
95CDK80.08538561
96CSNK2A10.08274280
97MAP3K100.08077819
98PRKCQ0.06428884
99CDK70.05418285
100TAOK30.05261302

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.85402761
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.04201122
3Basal transcription factors_Homo sapiens_hsa030224.03918359
4Fatty acid biosynthesis_Homo sapiens_hsa000613.72089263
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.33842666
6Linoleic acid metabolism_Homo sapiens_hsa005913.31016068
7Pyruvate metabolism_Homo sapiens_hsa006203.12781289
8Oocyte meiosis_Homo sapiens_hsa041142.37505111
9Glucagon signaling pathway_Homo sapiens_hsa049222.31340457
10Pentose phosphate pathway_Homo sapiens_hsa000302.21171179
11Fanconi anemia pathway_Homo sapiens_hsa034602.15931401
12Propanoate metabolism_Homo sapiens_hsa006402.14836938
13Cell cycle_Homo sapiens_hsa041101.97001791
14RNA transport_Homo sapiens_hsa030131.90296964
15Glycerophospholipid metabolism_Homo sapiens_hsa005641.78303675
16Ether lipid metabolism_Homo sapiens_hsa005651.75714229
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72112714
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.68384921
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66333793
20Dorso-ventral axis formation_Homo sapiens_hsa043201.65562011
21Selenocompound metabolism_Homo sapiens_hsa004501.62040859
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59903572
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57345130
24Purine metabolism_Homo sapiens_hsa002301.53841757
25mRNA surveillance pathway_Homo sapiens_hsa030151.53484128
26Glycerolipid metabolism_Homo sapiens_hsa005611.52497760
27RNA degradation_Homo sapiens_hsa030181.46604575
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38142736
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27737420
30PPAR signaling pathway_Homo sapiens_hsa033201.23999406
31Mineral absorption_Homo sapiens_hsa049781.18254615
32Biosynthesis of amino acids_Homo sapiens_hsa012301.17605259
33Fructose and mannose metabolism_Homo sapiens_hsa000511.16486326
34Homologous recombination_Homo sapiens_hsa034401.14626037
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13896167
36Carbon metabolism_Homo sapiens_hsa012001.12664260
37Pyrimidine metabolism_Homo sapiens_hsa002401.11946975
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11508458
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06210545
40Amphetamine addiction_Homo sapiens_hsa050311.05876368
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01362823
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01152251
43Glutathione metabolism_Homo sapiens_hsa004800.97294306
44Fat digestion and absorption_Homo sapiens_hsa049750.96930360
45Arachidonic acid metabolism_Homo sapiens_hsa005900.94988709
46Base excision repair_Homo sapiens_hsa034100.86872709
47DNA replication_Homo sapiens_hsa030300.84508300
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83119199
49Huntingtons disease_Homo sapiens_hsa050160.81266090
50Fatty acid degradation_Homo sapiens_hsa000710.78974496
51Hedgehog signaling pathway_Homo sapiens_hsa043400.76506020
52Estrogen signaling pathway_Homo sapiens_hsa049150.73071693
53Fatty acid metabolism_Homo sapiens_hsa012120.72565297
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72116200
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68468587
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68451350
57Cardiac muscle contraction_Homo sapiens_hsa042600.66166968
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62072554
59Non-homologous end-joining_Homo sapiens_hsa034500.61284458
60VEGF signaling pathway_Homo sapiens_hsa043700.59617142
61Inositol phosphate metabolism_Homo sapiens_hsa005620.59559282
62Collecting duct acid secretion_Homo sapiens_hsa049660.57646275
63Renin-angiotensin system_Homo sapiens_hsa046140.57419928
64Ovarian steroidogenesis_Homo sapiens_hsa049130.55030424
65Antigen processing and presentation_Homo sapiens_hsa046120.54609547
66Insulin secretion_Homo sapiens_hsa049110.48373012
67Chemical carcinogenesis_Homo sapiens_hsa052040.48093194
68p53 signaling pathway_Homo sapiens_hsa041150.46219550
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46175737
70Thyroid hormone synthesis_Homo sapiens_hsa049180.45202443
71Long-term potentiation_Homo sapiens_hsa047200.44715298
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.42605159
73Renin secretion_Homo sapiens_hsa049240.41900551
74AMPK signaling pathway_Homo sapiens_hsa041520.40376591
75Spliceosome_Homo sapiens_hsa030400.39581596
76Metabolic pathways_Homo sapiens_hsa011000.37845283
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37640162
78Epstein-Barr virus infection_Homo sapiens_hsa051690.36617525
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.34675532
80Nucleotide excision repair_Homo sapiens_hsa034200.34287381
81RNA polymerase_Homo sapiens_hsa030200.34028805
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.32595267
83Endocytosis_Homo sapiens_hsa041440.29955222
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23459702
85Circadian rhythm_Homo sapiens_hsa047100.22212118
86Systemic lupus erythematosus_Homo sapiens_hsa053220.22016602
87Calcium signaling pathway_Homo sapiens_hsa040200.21000793
88Bile secretion_Homo sapiens_hsa049760.20987679
89Viral carcinogenesis_Homo sapiens_hsa052030.17315893
90Pancreatic secretion_Homo sapiens_hsa049720.17294778
91Wnt signaling pathway_Homo sapiens_hsa043100.16973939
92Synaptic vesicle cycle_Homo sapiens_hsa047210.16815344
93TGF-beta signaling pathway_Homo sapiens_hsa043500.14324316
94Notch signaling pathway_Homo sapiens_hsa043300.12718529
95cAMP signaling pathway_Homo sapiens_hsa040240.11300297
96Mismatch repair_Homo sapiens_hsa034300.09792077
97HIF-1 signaling pathway_Homo sapiens_hsa040660.09041977
98Choline metabolism in cancer_Homo sapiens_hsa052310.08946119
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07539415
100Proteasome_Homo sapiens_hsa030500.07477726

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