IPPK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)7.88748334
2establishment of skin barrier (GO:0061436)6.97999297
3regulation of water loss via skin (GO:0033561)6.86625283
4desmosome organization (GO:0002934)6.43131110
5piRNA metabolic process (GO:0034587)6.37448523
6regulation of female gonad development (GO:2000194)5.77624476
7hemidesmosome assembly (GO:0031581)5.23297801
8mitotic metaphase plate congression (GO:0007080)5.10722119
9COPI coating of Golgi vesicle (GO:0048205)5.01779003
10Golgi transport vesicle coating (GO:0048200)5.01779003
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.90139628
12regulation of exit from mitosis (GO:0007096)4.80290304
13histone H2A monoubiquitination (GO:0035518)4.79477774
14keratinocyte differentiation (GO:0030216)4.70263699
15negative regulation of meiosis (GO:0045835)4.65879240
16nuclear pore complex assembly (GO:0051292)4.51516937
17regulation of meiosis (GO:0040020)4.51248964
18protein K6-linked ubiquitination (GO:0085020)4.38264442
19DNA methylation involved in gamete generation (GO:0043046)4.27239446
20mitotic chromosome condensation (GO:0007076)4.26538663
21rRNA methylation (GO:0031167)4.18640793
22regulation of spindle organization (GO:0090224)4.17536716
23metaphase plate congression (GO:0051310)4.16931264
24nuclear pore organization (GO:0006999)4.13353464
25protein localization to kinetochore (GO:0034501)4.09119594
26female gamete generation (GO:0007292)4.06179242
27oocyte maturation (GO:0001556)4.05029870
28histone H2A ubiquitination (GO:0033522)4.02057170
29skin morphogenesis (GO:0043589)4.01525963
30rRNA modification (GO:0000154)4.00718826
31ribosome assembly (GO:0042255)3.95302230
32gene silencing by RNA (GO:0031047)3.92667626
33positive regulation of keratinocyte differentiation (GO:0045618)3.87970539
34regulation of acrosome reaction (GO:0060046)3.82710889
35epidermal cell differentiation (GO:0009913)3.81907801
36mitotic nuclear envelope disassembly (GO:0007077)3.81544817
37base-excision repair, AP site formation (GO:0006285)3.77593297
38multicellular organismal water homeostasis (GO:0050891)3.76597493
39regulation of sister chromatid cohesion (GO:0007063)3.76227990
40DNA damage induced protein phosphorylation (GO:0006975)3.74771295
41keratinocyte proliferation (GO:0043616)3.67542535
42negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.66268632
43negative regulation of DNA-templated transcription, elongation (GO:0032785)3.66268632
44positive regulation of chromosome segregation (GO:0051984)3.65728966
45histone H2B ubiquitination (GO:0033523)3.64458945
46membrane disassembly (GO:0030397)3.63978280
47nuclear envelope disassembly (GO:0051081)3.63978280
48meiotic cell cycle (GO:0051321)3.63860549
49attachment of spindle microtubules to kinetochore (GO:0008608)3.61265390
50establishment of chromosome localization (GO:0051303)3.58876500
51protein localization to chromosome, centromeric region (GO:0071459)3.57607018
52maturation of 5.8S rRNA (GO:0000460)3.57253000
53citrulline biosynthetic process (GO:0019240)3.56447563
54glycerophospholipid catabolic process (GO:0046475)3.56425650
55bundle of His cell to Purkinje myocyte communication (GO:0086069)3.55068269
56negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.53522334
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.52186542
58regulation of neuron projection regeneration (GO:0070570)3.50170044
59regulation of axon regeneration (GO:0048679)3.50170044
60folic acid-containing compound biosynthetic process (GO:0009396)3.49424880
61spindle checkpoint (GO:0031577)3.47373302
62cellular protein complex localization (GO:0034629)3.45516386
63DNA replication-dependent nucleosome assembly (GO:0006335)3.43464379
64DNA replication-dependent nucleosome organization (GO:0034723)3.43464379
65negative regulation of smooth muscle cell differentiation (GO:0051151)3.41241787
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40838463
67epithelial cell differentiation involved in prostate gland development (GO:0060742)3.40766173
68DNA replication checkpoint (GO:0000076)3.40104549
69regulation of chromosome segregation (GO:0051983)3.39858456
70regulation of meiotic cell cycle (GO:0051445)3.39324096
71positive regulation of epidermal cell differentiation (GO:0045606)3.36943488
72pore complex assembly (GO:0046931)3.36766760
73male meiosis (GO:0007140)3.36061456
74regulation of meiosis I (GO:0060631)3.34698969
75protein deneddylation (GO:0000338)3.33650405
76multicellular organism reproduction (GO:0032504)3.31059918
77mitotic spindle checkpoint (GO:0071174)3.30383394
78mitotic sister chromatid segregation (GO:0000070)3.29601143
79CENP-A containing nucleosome assembly (GO:0034080)3.29111203
80positive regulation of epidermis development (GO:0045684)3.28676991
81DNA replication initiation (GO:0006270)3.27755567
82mitochondrial fusion (GO:0008053)3.24457498
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23947682
84regulation of mitotic spindle organization (GO:0060236)3.22355768
85negative regulation of execution phase of apoptosis (GO:1900118)3.20435292
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19931562
87oocyte development (GO:0048599)3.18911003
88chromatin remodeling at centromere (GO:0031055)3.16322540
89regulation of centrosome cycle (GO:0046605)3.15110821
90nuclear envelope organization (GO:0006998)3.14197376
91cell-substrate junction assembly (GO:0007044)3.13221902
92N-terminal protein amino acid acetylation (GO:0006474)3.12680668
93protein localization to chromosome (GO:0034502)3.12577852
94histone-serine phosphorylation (GO:0035404)3.10978092
95ectoderm development (GO:0007398)3.09875170
96tRNA methylation (GO:0030488)3.09539190
97ribosome biogenesis (GO:0042254)3.09351057
98negative regulation of chromosome segregation (GO:0051985)3.09182904
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.08830382
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08830382
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08830382
102negative regulation of sister chromatid segregation (GO:0033046)3.08830382
103epidermis development (GO:0008544)3.06833641
104water homeostasis (GO:0030104)3.06449277
105mitotic spindle assembly checkpoint (GO:0007094)3.06256872
106DNA unwinding involved in DNA replication (GO:0006268)3.03697922
107DNA replication-independent nucleosome assembly (GO:0006336)3.01901608
108DNA replication-independent nucleosome organization (GO:0034724)3.01901608
109endothelium development (GO:0003158)3.00996926
110positive regulation of DNA-dependent DNA replication (GO:2000105)3.00509141
111regulation of retinoic acid receptor signaling pathway (GO:0048385)3.00421097
112proline biosynthetic process (GO:0006561)3.00402191
113spindle assembly checkpoint (GO:0071173)2.97617222
114protein complex localization (GO:0031503)2.96073063
115intestinal epithelial cell development (GO:0060576)2.95069683
116regulation of telomere maintenance via telomerase (GO:0032210)2.94014549
117nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.93956346
118protein localization to endosome (GO:0036010)2.93580337
119dosage compensation (GO:0007549)2.92607968
120negative regulation of nuclear division (GO:0051784)2.91696898
121regulation of NFAT protein import into nucleus (GO:0051532)2.91681855
122COPII vesicle coating (GO:0048208)2.90384996
123histone monoubiquitination (GO:0010390)2.90337691
124histone exchange (GO:0043486)2.89020534
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88788138
126notochord development (GO:0030903)2.87341578
127negative regulation of cell division (GO:0051782)2.86867849
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86630366
129regulation of histone H3-K27 methylation (GO:0061085)2.86263047
130activation of Rac GTPase activity (GO:0032863)2.86250622
131chromosome segregation (GO:0007059)2.85702981
132mitotic sister chromatid cohesion (GO:0007064)2.85463225
133snRNA transcription (GO:0009301)2.81239728
134meiotic chromosome segregation (GO:0045132)2.81218751
135negative regulation of meiotic cell cycle (GO:0051447)2.80090853
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79766618
137sister chromatid segregation (GO:0000819)2.79734436
138regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79544361
139cell adhesion mediated by integrin (GO:0033627)2.78660466
140meiotic nuclear division (GO:0007126)2.77490656
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76967111
142DNA alkylation (GO:0006305)2.76419066
143DNA methylation (GO:0006306)2.76419066
144peptide cross-linking (GO:0018149)2.74476849
145pyrimidine nucleotide catabolic process (GO:0006244)2.73763622
146vesicle coating (GO:0006901)2.72238549
147regulation of translational termination (GO:0006449)2.71048375
148hair cycle (GO:0042633)2.70704970
149molting cycle (GO:0042303)2.70704970
150nucleobase-containing small molecule interconversion (GO:0015949)2.69657462
151epithelial cell-cell adhesion (GO:0090136)2.67859009
152regulation of keratinocyte differentiation (GO:0045616)2.67583679
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65869538
154protein retention in ER lumen (GO:0006621)2.65558706
155regulation of RNA export from nucleus (GO:0046831)2.63623364
156positive regulation of DNA-templated transcription, elongation (GO:0032786)2.61393408
157regulation of translational fidelity (GO:0006450)2.60286849
158focal adhesion assembly (GO:0048041)2.60241712
159cell-substrate adherens junction assembly (GO:0007045)2.60241712
160regulation of DNA damage checkpoint (GO:2000001)2.59478351
161peptidyl-lysine dimethylation (GO:0018027)2.58997004
162regulation of nucleobase-containing compound transport (GO:0032239)2.58916505
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.57574093
164eyelid development in camera-type eye (GO:0061029)2.57560247
165positive regulation of nuclease activity (GO:0032075)2.57233522
166endoplasmic reticulum unfolded protein response (GO:0030968)2.56839187
167ER-nucleus signaling pathway (GO:0006984)2.52209158
168viral mRNA export from host cell nucleus (GO:0046784)2.50799060
169embryonic process involved in female pregnancy (GO:0060136)2.47705223
170regulation of mammary gland epithelial cell proliferation (GO:0033599)2.46218236
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46173787
172glutamine family amino acid biosynthetic process (GO:0009084)2.45263266
173positive regulation of Cdc42 GTPase activity (GO:0043089)2.44266787
174peptidyl-arginine omega-N-methylation (GO:0035247)2.44262056
175adherens junction assembly (GO:0034333)2.42365867
176protein localization to microtubule (GO:0035372)2.41733654
177mitotic nuclear envelope reassembly (GO:0007084)2.41581746
178nuclear envelope reassembly (GO:0031468)2.41581746
179linoleic acid metabolic process (GO:0043651)2.40247002
180negative regulation of keratinocyte proliferation (GO:0010839)2.39670699
181regulation of epidermis development (GO:0045682)2.39107407
182trophectodermal cell differentiation (GO:0001829)2.38308398
183cellular response to unfolded protein (GO:0034620)2.36247403
184regulation of protein export from nucleus (GO:0046825)2.36013267
185mRNA export from nucleus (GO:0006406)2.35210677
186protein export from nucleus (GO:0006611)2.34920260
187formation of translation preinitiation complex (GO:0001731)2.34335494
188regulation of nuclease activity (GO:0032069)2.32874812
189cellular response to arsenic-containing substance (GO:0071243)2.31893134
190regulation of epidermal cell differentiation (GO:0045604)2.31789673
191polarized epithelial cell differentiation (GO:0030859)2.31513923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.28505717
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.00321273
3AR_21909140_ChIP-Seq_LNCAP_Human3.72324553
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.54086930
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25326664
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90779162
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.86415599
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83648802
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82851648
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75371058
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74494076
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.61976000
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.61546607
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58412998
15* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.36878660
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35677633
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33360871
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31777916
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23442968
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23035497
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.22080054
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20294777
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14267563
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12969289
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.07996445
26MYC_22102868_ChIP-Seq_BL_Human2.07894532
27ZNF263_19887448_ChIP-Seq_K562_Human2.07615436
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05905378
29KAP1_22055183_ChIP-Seq_ESCs_Mouse2.05746682
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04851796
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97499148
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.97484414
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94140250
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94140250
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91537167
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.85125680
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85123651
38CLOCK_20551151_ChIP-Seq_293T_Human1.81080599
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77562316
40* GABP_19822575_ChIP-Seq_HepG2_Human1.76368863
41ATF3_27146783_Chip-Seq_COLON_Human1.74491556
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74395785
43* ETS1_20019798_ChIP-Seq_JURKAT_Human1.71823108
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71719871
45RACK7_27058665_Chip-Seq_MCF-7_Human1.71329585
46* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69231177
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.68561467
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67398265
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.65532058
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62926826
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62846160
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.61687992
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59848372
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56628293
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55661333
56VDR_23849224_ChIP-Seq_CD4+_Human1.55592442
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52997400
58MYC_18940864_ChIP-ChIP_HL60_Human1.52666218
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52399380
60VDR_21846776_ChIP-Seq_THP-1_Human1.52223731
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52136577
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50720428
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49818783
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48869774
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46229600
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44843425
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44114685
68TFEB_21752829_ChIP-Seq_HELA_Human1.43671409
69KDM5A_27292631_Chip-Seq_BREAST_Human1.43539508
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.42199676
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41283642
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.39833107
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39752181
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38185181
75DCP1A_22483619_ChIP-Seq_HELA_Human1.36184134
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.35577482
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33916183
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33703952
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32601007
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31924550
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29008955
82IGF1R_20145208_ChIP-Seq_DFB_Human1.28771410
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26575334
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25556560
85ELK1_19687146_ChIP-ChIP_HELA_Human1.25132483
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23050688
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22952715
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22621273
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22110895
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21856474
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19343116
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18152591
93* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18049434
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17432396
95TCF7_22412390_ChIP-Seq_EML_Mouse1.15445140
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14650037
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14391346
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14297742
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13633285
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12529434
101* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11733532
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11403162
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10982297
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10954709
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10886758
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09303669
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08523134
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08052373
109* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06744235
110EWS_26573619_Chip-Seq_HEK293_Human1.05230499
111XRN2_22483619_ChIP-Seq_HELA_Human1.04578210
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.04436073
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02763998
114* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01463470
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.01085762
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01023081
117* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00442559
118CDX2_22108803_ChIP-Seq_LS180_Human1.00061663
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98619646
120* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98510707
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97153363
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.97085698
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96907742
124KDM2B_26808549_Chip-Seq_DND41_Human0.96643619
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96516892
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96072573
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.95896605
128* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95711527
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95447437
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92672795
131FOXP3_21729870_ChIP-Seq_TREG_Human0.90537801
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90226347
133EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89958382
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.89430216
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.87997335
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86362334
137STAT3_23295773_ChIP-Seq_U87_Human0.86193951
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85807148
139TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85537166
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85326804
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84126943
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84072453
143TTF2_22483619_ChIP-Seq_HELA_Human0.84052247
144FUS_26573619_Chip-Seq_HEK293_Human0.82145496
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81383863
146CHD1_26751641_Chip-Seq_LNCaP_Human0.80708062
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80301463
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79605106
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79461028
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.79247717
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.77632507
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76483595
153TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75947242
154NFYA_21822215_ChIP-Seq_K562_Human0.74761929
155PHF8_20622853_ChIP-Seq_HELA_Human0.73514906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.80972410
2MP0003693_abnormal_embryo_hatching5.11457625
3MP0008877_abnormal_DNA_methylation3.90795522
4MP0010094_abnormal_chromosome_stability3.88234733
5MP0003111_abnormal_nucleus_morphology3.71300029
6MP0004957_abnormal_blastocyst_morpholog3.54097733
7MP0003123_paternal_imprinting3.41297892
8MP0003705_abnormal_hypodermis_morpholog3.37694970
9MP0003077_abnormal_cell_cycle3.19551166
10MP0005451_abnormal_body_composition2.82254935
11MP0004264_abnormal_extraembryonic_tissu2.77337888
12MP0003941_abnormal_skin_development2.61614845
13MP0004782_abnormal_surfactant_physiolog2.59017474
14MP0001216_abnormal_epidermal_layer2.55249564
15MP0003566_abnormal_cell_adhesion2.46805915
16MP0008932_abnormal_embryonic_tissue2.45004012
17MP0005275_abnormal_skin_tensile2.35866270
18MP0005395_other_phenotype2.28478064
19MP0005646_abnormal_pituitary_gland2.27498077
20MP0002098_abnormal_vibrissa_morphology2.23226650
21MP0001730_embryonic_growth_arrest2.21299463
22MP0003699_abnormal_female_reproductive2.18511001
23MP0001929_abnormal_gametogenesis2.15432480
24MP0002877_abnormal_melanocyte_morpholog2.15122735
25MP0002060_abnormal_skin_morphology2.06304630
26MP0002102_abnormal_ear_morphology2.02728441
27MP0000467_abnormal_esophagus_morphology2.00307228
28MP0010771_integument_phenotype1.97836543
29MP0003806_abnormal_nucleotide_metabolis1.96503614
30MP0003121_genomic_imprinting1.95818146
31MP0000653_abnormal_sex_gland1.90832601
32MP0000377_abnormal_hair_follicle1.79167720
33MP0005408_hypopigmentation1.78887917
34MP0002210_abnormal_sex_determination1.76042604
35MP0008057_abnormal_DNA_replication1.75304085
36MP0005076_abnormal_cell_differentiation1.74566887
37MP0001119_abnormal_female_reproductive1.69413054
38MP0003646_muscle_fatigue1.69400868
39MP0003191_abnormal_cellular_cholesterol1.69298301
40MP0008007_abnormal_cellular_replicative1.67501074
41MP0004233_abnormal_muscle_weight1.67290900
42MP0003183_abnormal_peptide_metabolism1.66157177
43MP0006292_abnormal_olfactory_placode1.60996710
44MP0000762_abnormal_tongue_morphology1.59288791
45MP0010678_abnormal_skin_adnexa1.53967937
46MP0002085_abnormal_embryonic_tissue1.52264786
47MP0000350_abnormal_cell_proliferation1.51183673
48MP0004947_skin_inflammation1.46410442
49MP0001145_abnormal_male_reproductive1.45266173
50MP0001672_abnormal_embryogenesis/_devel1.45138014
51MP0005380_embryogenesis_phenotype1.45138014
52MP0002084_abnormal_developmental_patter1.44320202
53MP0010234_abnormal_vibrissa_follicle1.43966979
54MP0001697_abnormal_embryo_size1.42638068
55MP0003937_abnormal_limbs/digits/tail_de1.42209599
56MP0000462_abnormal_digestive_system1.41521307
57MP0010307_abnormal_tumor_latency1.41437768
58MP0003786_premature_aging1.32578994
59MP0009931_abnormal_skin_appearance1.32311919
60MP0001529_abnormal_vocalization1.31280872
61MP0002161_abnormal_fertility/fecundity1.28346478
62MP0000383_abnormal_hair_follicle1.24601050
63MP0004185_abnormal_adipocyte_glucose1.23883633
64MP0003890_abnormal_embryonic-extraembry1.23624472
65MP0003315_abnormal_perineum_morphology1.20508189
66MP0003787_abnormal_imprinting1.18236400
67MP0005409_darkened_coat_color1.16982600
68* MP0002080_prenatal_lethality1.16137225
69MP0008058_abnormal_DNA_repair1.15909388
70MP0005187_abnormal_penis_morphology1.15194065
71MP0003453_abnormal_keratinocyte_physiol1.15029721
72MP0001905_abnormal_dopamine_level1.14542695
73MP0004381_abnormal_hair_follicle1.14539890
74MP0001188_hyperpigmentation1.14482254
75MP0003656_abnormal_erythrocyte_physiolo1.13235715
76MP0008260_abnormal_autophagy1.12605877
77MP0002086_abnormal_extraembryonic_tissu1.12249512
78MP0003984_embryonic_growth_retardation1.11158706
79MP0002019_abnormal_tumor_incidence1.10598464
80MP0002295_abnormal_pulmonary_circulatio1.09280839
81MP0000427_abnormal_hair_cycle1.07946756
82MP0004147_increased_porphyrin_level1.05457950
83MP0002088_abnormal_embryonic_growth/wei1.05019929
84MP0000579_abnormal_nail_morphology1.03919810
85MP0010030_abnormal_orbit_morphology1.03863486
86MP0005389_reproductive_system_phenotype1.02538116
87MP0001849_ear_inflammation1.00564351
88MP0005220_abnormal_exocrine_pancreas0.99367351
89MP0000733_abnormal_muscle_development0.97059141
90MP0001191_abnormal_skin_condition0.96779372
91MP0001243_abnormal_dermal_layer0.95189360
92MP0001919_abnormal_reproductive_system0.91624907
93MP0009053_abnormal_anal_canal0.91037089
94MP0000678_abnormal_parathyroid_gland0.90019946
95MP0000627_abnormal_mammary_gland0.89585830
96MP0000750_abnormal_muscle_regeneration0.89240851
97MP0005621_abnormal_cell_physiology0.89129750
98MP0005023_abnormal_wound_healing0.88134243
99MP0000537_abnormal_urethra_morphology0.87632317
100MP0000490_abnormal_crypts_of0.87457679
101MP0005384_cellular_phenotype0.84518014
102MP0009384_cardiac_valve_regurgitation0.84110581
103MP0003698_abnormal_male_reproductive0.83221961
104MP0003950_abnormal_plasma_membrane0.83133132
105MP0000613_abnormal_salivary_gland0.82142331
106MP0002653_abnormal_ependyma_morphology0.81231829
107MP0001915_intracranial_hemorrhage0.79922144
108MP0002254_reproductive_system_inflammat0.78856849
109MP0001340_abnormal_eyelid_morphology0.76728846
110MP0004270_analgesia0.76171596
111MP0005666_abnormal_adipose_tissue0.76020392
112MP0000313_abnormal_cell_death0.74470751
113MP0009697_abnormal_copulation0.74297737
114MP0005058_abnormal_lysosome_morphology0.74249659
115MP0010352_gastrointestinal_tract_polyps0.74060801
116MP0000367_abnormal_coat/_hair0.73799181
117MP0004808_abnormal_hematopoietic_stem0.73586498
118MP0008004_abnormal_stomach_pH0.73501353
119MP0006054_spinal_hemorrhage0.72134535
120MP0002160_abnormal_reproductive_system0.69815845
121MP0005375_adipose_tissue_phenotype0.69268583
122MP0003861_abnormal_nervous_system0.68149737
123MP0002092_abnormal_eye_morphology0.67497331
124MP0003632_abnormal_nervous_system0.67262585
125MP0000858_altered_metastatic_potential0.67013865
126MP0003385_abnormal_body_wall0.66566989
127MP0001348_abnormal_lacrimal_gland0.66518448
128MP0003091_abnormal_cell_migration0.65660449
129MP0000003_abnormal_adipose_tissue0.64882930
130MP0002177_abnormal_outer_ear0.64562153
131MP0009840_abnormal_foam_cell0.64546271
132MP0003115_abnormal_respiratory_system0.64499879
133MP0000465_gastrointestinal_hemorrhage0.63638020
134MP0001485_abnormal_pinna_reflex0.63215023
135MP0002234_abnormal_pharynx_morphology0.63162183
136MP0003186_abnormal_redox_activity0.63070583
137MP0001346_abnormal_lacrimal_gland0.62935749
138MP0003221_abnormal_cardiomyocyte_apopto0.60951355
139MP0002269_muscular_atrophy0.59479834
140MP0003119_abnormal_digestive_system0.56682243
141MP0000566_synostosis0.56098355
142MP0009672_abnormal_birth_weight0.54489304
143MP0000759_abnormal_skeletal_muscle0.53848717
144MP0005501_abnormal_skin_physiology0.53439558
145MP0004197_abnormal_fetal_growth/weight/0.52390573
146MP0002796_impaired_skin_barrier0.50944453
147MP0000647_abnormal_sebaceous_gland0.49392083
148MP0003329_amyloid_beta_deposits0.48787789
149MP0002111_abnormal_tail_morphology0.48313373
150MP0000358_abnormal_cell_content/0.48299623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.42335472
2Birth length less than 3rd percentile (HP:0003561)5.24873196
3Breast hypoplasia (HP:0003187)4.75024699
4Premature ovarian failure (HP:0008209)4.73736163
5Thick nail (HP:0001805)4.67272050
6Palmoplantar hyperkeratosis (HP:0000972)4.66954969
7Onycholysis (HP:0001806)4.58183922
8Plantar hyperkeratosis (HP:0007556)4.54117548
9Flat capital femoral epiphysis (HP:0003370)4.43737419
10Palmar hyperkeratosis (HP:0010765)4.41896694
11Congenital ichthyosiform erythroderma (HP:0007431)4.15432261
12Secondary amenorrhea (HP:0000869)4.11409796
13Cerebral hypomyelination (HP:0006808)3.92868398
14Adrenal hypoplasia (HP:0000835)3.90001933
15Fragile nails (HP:0001808)3.84487673
16Chromsome breakage (HP:0040012)3.76152653
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.66090200
18Natal tooth (HP:0000695)3.52678734
19Alopecia of scalp (HP:0002293)3.51750120
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51189754
21Nail dystrophy (HP:0008404)3.50138746
22Hypergonadotropic hypogonadism (HP:0000815)3.45942208
23Erythroderma (HP:0001019)3.45475608
24Erythema (HP:0010783)3.41582272
25Abnormality of the labia minora (HP:0012880)3.41013264
26Male infertility (HP:0003251)3.37793015
27Papillary thyroid carcinoma (HP:0002895)3.37454386
28Carpal bone hypoplasia (HP:0001498)3.37255507
29Hypotrichosis (HP:0001006)3.32485167
30Abnormality of chromosome segregation (HP:0002916)3.21974617
31Milia (HP:0001056)3.20140304
32Right ventricular cardiomyopathy (HP:0011663)3.15955837
33Increased IgE level (HP:0003212)3.13142639
34CNS hypomyelination (HP:0003429)3.03907900
35Irregular epiphyses (HP:0010582)3.00129946
36Ridged nail (HP:0001807)3.00085348
37Pili torti (HP:0003777)2.99483662
38Abnormality of chromosome stability (HP:0003220)2.96891564
39Rhabdomyosarcoma (HP:0002859)2.93944651
40Hyperglycemia (HP:0003074)2.89142463
41Facial hemangioma (HP:0000329)2.87324266
42Corneal erosion (HP:0200020)2.79230715
43Selective tooth agenesis (HP:0001592)2.78939528
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.74997212
45Supernumerary spleens (HP:0009799)2.68831149
46Autoamputation (HP:0001218)2.68674406
47Sparse eyelashes (HP:0000653)2.67285699
48Patellar aplasia (HP:0006443)2.65785195
49Capillary hemangiomas (HP:0005306)2.65314007
50Advanced eruption of teeth (HP:0006288)2.62849183
51Breast aplasia (HP:0100783)2.59829497
52Entropion (HP:0000621)2.59012407
53Insomnia (HP:0100785)2.58307463
54Absent radius (HP:0003974)2.58015803
55Progressive muscle weakness (HP:0003323)2.57747125
56Abnormality of the salivary glands (HP:0010286)2.55788830
57Postnatal microcephaly (HP:0005484)2.52748537
58Abnormality of the fovea (HP:0000493)2.52129687
59Rough bone trabeculation (HP:0100670)2.50533413
60Ectropion (HP:0000656)2.50283506
61Aplasia/Hypoplasia of the breasts (HP:0010311)2.49484907
62Cortical dysplasia (HP:0002539)2.46757587
63Absent eyelashes (HP:0000561)2.46075107
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43716248
65Ureteral duplication (HP:0000073)2.43701295
66Abnormality of the preputium (HP:0100587)2.43649779
67Aplasia/Hypoplasia of the patella (HP:0006498)2.43252611
68Abnormal hair laboratory examination (HP:0003328)2.42444967
69Hyperacusis (HP:0010780)2.38610782
70Insulin-resistant diabetes mellitus (HP:0000831)2.37673295
71Aplasia involving forearm bones (HP:0009822)2.36890055
72Absent forearm bone (HP:0003953)2.36890055
73Hypoplasia of the uterus (HP:0000013)2.35601482
74Hypoplasia of the fovea (HP:0007750)2.35397696
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.35397696
76Sloping forehead (HP:0000340)2.34333317
77Abnormal blistering of the skin (HP:0008066)2.34327453
78Aplastic anemia (HP:0001915)2.33557678
79Distal lower limb amyotrophy (HP:0008944)2.33399211
80Trismus (HP:0000211)2.33018570
81Hypoplastic pelvis (HP:0008839)2.32999434
82Parakeratosis (HP:0001036)2.29886931
83Oral leukoplakia (HP:0002745)2.28335866
84Meckel diverticulum (HP:0002245)2.28004571
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.25881351
86Hypohidrosis (HP:0000966)2.25514958
87Long palpebral fissure (HP:0000637)2.24313055
88Multiple enchondromatosis (HP:0005701)2.24132079
89Distal lower limb muscle weakness (HP:0009053)2.22949291
90Curly hair (HP:0002212)2.20229133
91Palmoplantar keratoderma (HP:0000982)2.19746487
92Squamous cell carcinoma (HP:0002860)2.19707316
93Blepharitis (HP:0000498)2.18275816
94Short nail (HP:0001799)2.14161439
95Abnormal trabecular bone morphology (HP:0100671)2.12016166
96Duodenal stenosis (HP:0100867)2.11641420
97Small intestinal stenosis (HP:0012848)2.11641420
98Shoulder girdle muscle weakness (HP:0003547)2.11385683
99Sparse scalp hair (HP:0002209)2.10554407
100Abnormal spermatogenesis (HP:0008669)2.05870845
101Microvesicular hepatic steatosis (HP:0001414)2.05245045
102Woolly hair (HP:0002224)2.04365144
103Atrophic scars (HP:0001075)2.04135760
104Horseshoe kidney (HP:0000085)2.02112615
105Insidious onset (HP:0003587)2.01516368
106Termporal pattern (HP:0011008)2.01516368
107Pulmonary fibrosis (HP:0002206)2.00764876
108Abnormality of the ileum (HP:0001549)2.00760548
109Premature graying of hair (HP:0002216)2.00473264
110Infertility (HP:0000789)2.00212162
111Sparse lateral eyebrow (HP:0005338)1.99887548
112Deviation of the thumb (HP:0009603)1.98372421
113Abnormality of DNA repair (HP:0003254)1.96755840
114Abnormality of vitamin B metabolism (HP:0004340)1.96666205
115Cafe-au-lait spot (HP:0000957)1.96645569
116Degeneration of anterior horn cells (HP:0002398)1.95584493
117Abnormality of the anterior horn cell (HP:0006802)1.95584493
118Vascular tortuosity (HP:0004948)1.94939304
119Abnormal biliary tract morphology (HP:0012440)1.94752500
120Megaloblastic anemia (HP:0001889)1.93435827
121Abnormality of the duodenum (HP:0002246)1.92807931
122Freckling (HP:0001480)1.91718493
123Progressive external ophthalmoplegia (HP:0000590)1.91465882
124Ankyloglossia (HP:0010296)1.91058393
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88011298
126Abnormality of alanine metabolism (HP:0010916)1.88011298
127Hyperalaninemia (HP:0003348)1.88011298
128Proximal placement of thumb (HP:0009623)1.87864328
129Abnormality of the distal phalanges of the toes (HP:0010182)1.87770972
130Shawl scrotum (HP:0000049)1.87602468
131Deep philtrum (HP:0002002)1.86586405
132Myelodysplasia (HP:0002863)1.86575729
133Spastic diplegia (HP:0001264)1.86304749
134Abnormal auditory evoked potentials (HP:0006958)1.86102159
135Conjunctival hamartoma (HP:0100780)1.85928398
136Pelvic girdle muscle weakness (HP:0003749)1.85807423
137Progressive hearing impairment (HP:0001730)1.84973501
138Abnormality of the epiphysis of the femoral head (HP:0010574)1.83359926
139Abnormality of the axillary hair (HP:0100134)1.83301895
140Abnormality of secondary sexual hair (HP:0009888)1.83301895
141Slow saccadic eye movements (HP:0000514)1.82623439
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81350142
143Type 2 muscle fiber atrophy (HP:0003554)1.80377090
144Septate vagina (HP:0001153)1.80178770
145Abnormality of the umbilical cord (HP:0010881)1.79235302
146Difficulty climbing stairs (HP:0003551)1.78183749
147Abnormality of the femoral head (HP:0003368)1.78045524
148Abnormalities of placenta or umbilical cord (HP:0001194)1.77906870
149Duplicated collecting system (HP:0000081)1.76908686
150Neoplasm of striated muscle (HP:0009728)1.76907239
151Delayed puberty (HP:0000823)1.76176014
152Achilles tendon contracture (HP:0001771)1.75930863
153Vertebral compression fractures (HP:0002953)1.75525091
154Progressive sensorineural hearing impairment (HP:0000408)1.75431192
155Atelectasis (HP:0100750)1.75307146
156Unsteady gait (HP:0002317)1.75095038
157Neoplasm of the oral cavity (HP:0100649)1.73950390
158Prolonged neonatal jaundice (HP:0006579)1.72995693
159Hypogonadotrophic hypogonadism (HP:0000044)1.72741349
160Abnormality of the gastric mucosa (HP:0004295)1.72262306
161Apathy (HP:0000741)1.72115939
162Poikiloderma (HP:0001029)1.71723724
163Abnormality of the sella turcica (HP:0002679)1.71541205
164Impulsivity (HP:0100710)1.70974401
165Delusions (HP:0000746)1.70948118
166Abnormality of femoral epiphyses (HP:0006499)1.70358642
167Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.70358642
168Personality changes (HP:0000751)1.70262875
169Ragged-red muscle fibers (HP:0003200)1.69526625
170Hypoplastic toenails (HP:0001800)1.68215024
171Sandal gap (HP:0001852)1.67157315
172Abnormal umbilical cord blood vessels (HP:0011403)1.66524686
173Single umbilical artery (HP:0001195)1.66524686
174Abnormality of the fetal cardiovascular system (HP:0010948)1.66524686
175Death in infancy (HP:0001522)1.66387959
176Bone marrow hypocellularity (HP:0005528)1.66187558
177Thyroid carcinoma (HP:0002890)1.65608047
178Abnormality of the clitoris (HP:0000056)1.65555960
179Medulloblastoma (HP:0002885)1.65188940
180Lip pit (HP:0100267)1.63135809
181Agnosia (HP:0010524)1.63000159
182Pancreatic cysts (HP:0001737)1.62534035
183Abnormality of the septum pellucidum (HP:0007375)1.61739672
184Tetraparesis (HP:0002273)1.61165177
185Micronodular cirrhosis (HP:0001413)1.58547254
186Deep palmar crease (HP:0006191)1.57621692
187Distal upper limb amyotrophy (HP:0007149)1.57425478
188Upper limb amyotrophy (HP:0009129)1.57425478
189Abnormality of the periventricular white matter (HP:0002518)1.56711886
190Overriding aorta (HP:0002623)1.55834771
191Supranuclear gaze palsy (HP:0000605)1.55670045
192Distal sensory impairment (HP:0002936)1.55630009
193Amniotic constriction ring (HP:0009775)1.54371152
194Abnormality of placental membranes (HP:0011409)1.54371152
195Cubitus valgus (HP:0002967)1.54332642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK3.68456337
2CDC73.49308472
3ERBB43.34740291
4IRAK33.30524514
5KSR23.27043391
6NME23.22998289
7BRAF3.10580653
8LATS13.08071892
9MAP3K63.03662396
10PBK2.99515720
11CDK122.80589144
12PLK42.77560887
13EEF2K2.70691749
14RAF12.33343331
15ACVR1B2.26912996
16MAPKAPK32.17737971
17EIF2AK12.17467157
18LATS22.17172524
19MST1R2.14356143
20BUB12.14173012
21TRIB32.11716854
22STK38L2.09484701
23MUSK2.05167009
24SMG12.03691844
25PRPF4B1.87506895
26SIK11.87398254
27MAPKAPK51.85468261
28RPS6KB21.85158800
29MELK1.83548059
30KSR11.82537216
31STK31.67222112
32CHEK21.66277635
33NEK21.62944277
34EIF2AK31.62140057
35EPHA21.59578745
36PIM21.58723617
37PLK11.57918343
38ARAF1.56634423
39WEE11.56620320
40STK101.55396643
41MAP3K91.54659549
42RIPK11.51627648
43MAP3K81.47553584
44BRSK21.42544859
45TESK11.36156412
46PRKD31.35282659
47ERN11.29750423
48TAOK31.29645183
49PKN21.24737520
50ICK1.24071358
51TAOK21.19363788
52PLK31.19317367
53MAP3K131.17260098
54PAK41.16735801
55MAP3K141.14774739
56PDGFRA1.13405303
57STK241.06927248
58TTN1.05271505
59TSSK61.05203646
60NEK11.05001749
61STK391.04537923
62AURKB1.02918642
63MOS1.01785761
64IRAK21.01455276
65TAOK11.01376523
66MAP2K71.00507677
67WNK30.98948379
68PAK60.97571294
69CDK80.97320654
70SCYL20.94786180
71SIK30.94453138
72CASK0.94389129
73MAPK130.91941856
74MTOR0.91583583
75BRD40.89113181
76AURKA0.87801026
77EPHA30.86566988
78AKT30.84721369
79BMPR1B0.81860020
80MAP3K20.81770712
81PDK20.78475560
82CHEK10.77940880
83VRK10.77222614
84CDK70.70491782
85SRPK10.70252472
86MATK0.69467655
87CDK60.68852626
88MAP2K10.68609358
89MAP2K30.67278625
90NTRK30.65859230
91MAP3K30.65787172
92BRSK10.65478996
93NEK60.64609686
94MET0.64413645
95DYRK30.63428872
96PINK10.62856478
97MAP3K50.61450526
98ATM0.56132738
99AKT20.55049129
100TESK20.50984714
101DYRK20.50510990
102ALK0.50244860
103ATR0.49389373
104EPHA40.47929117
105CDK40.45684252
106MARK20.45106851
107DMPK0.44115451
108CSNK1D0.43895496
109CDK90.43867079
110RET0.43413431
111RPS6KA50.43283812
112WNK40.42176220
113CDK30.41982711
114CDK20.41384087
115BMX0.41077081
116CSNK1E0.40955899
117MAP2K40.40294080
118EPHB10.40112110
119PRKD20.38300893
120CDK10.37924429
121MAPK110.37539390
122MAP3K110.37336995
123TRPM70.36918298
124NTRK10.36864777
125MAP3K100.36357312
126IRAK40.36203032
127PAK10.35191535
128RPS6KA40.34921376
129TYRO30.34914480
130PRKAA20.33918705
131NLK0.33515379
132PLK20.32870328
133BCR0.32367149
134CSNK1G20.32159009
135PAK30.32085331
136BMPR20.30414451
137MAP3K10.29874165
138PTK20.29848327
139EPHB20.29404139
140PRKCI0.29210857
141ZAK0.28919294
142RPS6KB10.28696705
143CSNK1G10.27966883
144TRIM280.27934336
145FGFR10.27646634
146PRKAA10.27463553
147SGK2230.26792974
148SGK4940.26792974
149CSNK1A10.26577715
150RPS6KA20.26297367
151ABL20.25321246
152FGR0.24266547

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.21872941
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61024669
3Cell cycle_Homo sapiens_hsa041103.20129743
4Basal transcription factors_Homo sapiens_hsa030223.11223408
5RNA degradation_Homo sapiens_hsa030182.73316968
6RNA transport_Homo sapiens_hsa030132.71722544
7RNA polymerase_Homo sapiens_hsa030202.69712442
8Homologous recombination_Homo sapiens_hsa034402.46714773
9DNA replication_Homo sapiens_hsa030302.44720065
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36897375
11Mismatch repair_Homo sapiens_hsa034302.33982788
12Ether lipid metabolism_Homo sapiens_hsa005652.26192061
13Fanconi anemia pathway_Homo sapiens_hsa034602.10596717
14Linoleic acid metabolism_Homo sapiens_hsa005912.08897517
15Nucleotide excision repair_Homo sapiens_hsa034202.05785213
16Ovarian steroidogenesis_Homo sapiens_hsa049131.99353008
17Steroid biosynthesis_Homo sapiens_hsa001001.97878516
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94678921
19Base excision repair_Homo sapiens_hsa034101.87897960
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85586412
21Oocyte meiosis_Homo sapiens_hsa041141.81057374
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.79348264
23Acute myeloid leukemia_Homo sapiens_hsa052211.70569363
24p53 signaling pathway_Homo sapiens_hsa041151.63452703
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57838436
26Circadian rhythm_Homo sapiens_hsa047101.55361048
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55089182
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52078813
29Protein export_Homo sapiens_hsa030601.44385078
30Vibrio cholerae infection_Homo sapiens_hsa051101.43906716
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39687676
32Pyrimidine metabolism_Homo sapiens_hsa002401.37135567
33mRNA surveillance pathway_Homo sapiens_hsa030151.34839114
34ErbB signaling pathway_Homo sapiens_hsa040121.34234032
35Fructose and mannose metabolism_Homo sapiens_hsa000511.30126326
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.27836044
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27485127
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.27300479
39Non-homologous end-joining_Homo sapiens_hsa034501.26549640
40One carbon pool by folate_Homo sapiens_hsa006701.22760550
41Non-small cell lung cancer_Homo sapiens_hsa052231.20008620
42Sphingolipid metabolism_Homo sapiens_hsa006001.18819464
43Purine metabolism_Homo sapiens_hsa002301.14000506
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12697959
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09664446
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09103784
47Pancreatic cancer_Homo sapiens_hsa052121.08545748
48Spliceosome_Homo sapiens_hsa030401.08149047
49Glioma_Homo sapiens_hsa052141.07152664
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04027056
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03672395
52MicroRNAs in cancer_Homo sapiens_hsa052061.03156122
53Other glycan degradation_Homo sapiens_hsa005111.03090940
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.02899410
55Arginine and proline metabolism_Homo sapiens_hsa003301.01931640
56Thyroid cancer_Homo sapiens_hsa052161.01913262
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00558149
58Insulin signaling pathway_Homo sapiens_hsa049100.97707126
59Arginine biosynthesis_Homo sapiens_hsa002200.97701026
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.96952898
61Proteoglycans in cancer_Homo sapiens_hsa052050.96946180
62Hepatitis C_Homo sapiens_hsa051600.94823913
63Folate biosynthesis_Homo sapiens_hsa007900.94584882
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93559453
65Lysosome_Homo sapiens_hsa041420.92185487
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91588660
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91261987
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88714469
69Apoptosis_Homo sapiens_hsa042100.85778480
70Hepatitis B_Homo sapiens_hsa051610.83494455
71TGF-beta signaling pathway_Homo sapiens_hsa043500.83266274
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82504160
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82125967
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80795539
75TNF signaling pathway_Homo sapiens_hsa046680.80367581
76Bladder cancer_Homo sapiens_hsa052190.79316658
77* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76976208
78Salmonella infection_Homo sapiens_hsa051320.76473322
79Estrogen signaling pathway_Homo sapiens_hsa049150.76111788
80Viral carcinogenesis_Homo sapiens_hsa052030.74761572
81Galactose metabolism_Homo sapiens_hsa000520.73694322
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73148404
83VEGF signaling pathway_Homo sapiens_hsa043700.72252467
84GnRH signaling pathway_Homo sapiens_hsa049120.71778648
85Choline metabolism in cancer_Homo sapiens_hsa052310.71747914
86Dorso-ventral axis formation_Homo sapiens_hsa043200.70143570
87AMPK signaling pathway_Homo sapiens_hsa041520.70136866
88Colorectal cancer_Homo sapiens_hsa052100.69733920
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68466356
90Adherens junction_Homo sapiens_hsa045200.68436584
91Focal adhesion_Homo sapiens_hsa045100.67663436
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67049572
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.64924210
94Vitamin digestion and absorption_Homo sapiens_hsa049770.64694083
95Carbon metabolism_Homo sapiens_hsa012000.63794170
96Notch signaling pathway_Homo sapiens_hsa043300.63157687
97Amoebiasis_Homo sapiens_hsa051460.62477312
98Renal cell carcinoma_Homo sapiens_hsa052110.62361432
99Hippo signaling pathway_Homo sapiens_hsa043900.61095461
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60898340
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60747144
102Ras signaling pathway_Homo sapiens_hsa040140.59309034
103Endocytosis_Homo sapiens_hsa041440.58923667
104Sulfur relay system_Homo sapiens_hsa041220.58727472
105Legionellosis_Homo sapiens_hsa051340.57436713
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56538714
107Tight junction_Homo sapiens_hsa045300.56329915
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56256531
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56158507
110B cell receptor signaling pathway_Homo sapiens_hsa046620.54956315
111Long-term depression_Homo sapiens_hsa047300.54689387
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54531867
113Herpes simplex infection_Homo sapiens_hsa051680.53615479
114Arachidonic acid metabolism_Homo sapiens_hsa005900.53362017
115HIF-1 signaling pathway_Homo sapiens_hsa040660.53096264
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.52890343
117Proteasome_Homo sapiens_hsa030500.51712717
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51495444
119Histidine metabolism_Homo sapiens_hsa003400.50978478
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46490419
121Small cell lung cancer_Homo sapiens_hsa052220.46478842
122Shigellosis_Homo sapiens_hsa051310.46310717
123Regulation of autophagy_Homo sapiens_hsa041400.46044848
124Prostate cancer_Homo sapiens_hsa052150.45495387
125N-Glycan biosynthesis_Homo sapiens_hsa005100.44904476
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.43350401
127Epstein-Barr virus infection_Homo sapiens_hsa051690.43002782
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42371448
129Systemic lupus erythematosus_Homo sapiens_hsa053220.41933516
130FoxO signaling pathway_Homo sapiens_hsa040680.41901805
131Biosynthesis of amino acids_Homo sapiens_hsa012300.40272425
132* Inositol phosphate metabolism_Homo sapiens_hsa005620.38548507
133Selenocompound metabolism_Homo sapiens_hsa004500.37309462
134mTOR signaling pathway_Homo sapiens_hsa041500.36773268
135Endometrial cancer_Homo sapiens_hsa052130.36505090
136HTLV-I infection_Homo sapiens_hsa051660.35646880
137Glutathione metabolism_Homo sapiens_hsa004800.35074960
138Alcoholism_Homo sapiens_hsa050340.34804177
139Pancreatic secretion_Homo sapiens_hsa049720.32942987
140Pentose phosphate pathway_Homo sapiens_hsa000300.31889668
141Glycerolipid metabolism_Homo sapiens_hsa005610.31252270
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.30927338
143Serotonergic synapse_Homo sapiens_hsa047260.29998232
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28999101
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26279182
146Sulfur metabolism_Homo sapiens_hsa009200.26007798
147Prolactin signaling pathway_Homo sapiens_hsa049170.25421546
148Melanoma_Homo sapiens_hsa052180.24885320
149Fat digestion and absorption_Homo sapiens_hsa049750.24446327
150Fatty acid elongation_Homo sapiens_hsa000620.24335009
151Chronic myeloid leukemia_Homo sapiens_hsa052200.23467707
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22450124

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