IPO9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.40996998
2DNA strand elongation (GO:0022616)4.22277774
3DNA unwinding involved in DNA replication (GO:0006268)4.18225053
4DNA replication initiation (GO:0006270)3.96960886
5pre-miRNA processing (GO:0031054)3.85099647
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68123224
7glucocorticoid receptor signaling pathway (GO:0042921)3.62585417
8nuclear pore organization (GO:0006999)3.60209104
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.57724625
10peptidyl-lysine dimethylation (GO:0018027)3.56967340
11nuclear pore complex assembly (GO:0051292)3.54158659
12DNA replication checkpoint (GO:0000076)3.46981719
13synaptic vesicle maturation (GO:0016188)3.46696160
14establishment of nucleus localization (GO:0040023)3.38277751
15layer formation in cerebral cortex (GO:0021819)3.35527473
16peptidyl-arginine methylation (GO:0018216)3.34145903
17peptidyl-arginine N-methylation (GO:0035246)3.34145903
18mitotic sister chromatid cohesion (GO:0007064)3.29137316
19peptidyl-arginine omega-N-methylation (GO:0035247)3.27934060
20telomere maintenance via semi-conservative replication (GO:0032201)3.21944721
21heterochromatin organization (GO:0070828)3.16800804
22chromatin remodeling at centromere (GO:0031055)3.12419353
23regulation of centriole replication (GO:0046599)3.09932627
24sister chromatid segregation (GO:0000819)3.09045708
25positive regulation of synapse maturation (GO:0090129)3.07203546
26paraxial mesoderm development (GO:0048339)3.07153727
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06324228
28meiotic chromosome segregation (GO:0045132)3.05685982
29protein localization to chromosome, centromeric region (GO:0071459)3.04464683
30establishment of integrated proviral latency (GO:0075713)3.01259978
31protein localization to kinetochore (GO:0034501)2.96530724
32hippo signaling (GO:0035329)2.96483481
33locomotory exploration behavior (GO:0035641)2.94596790
34L-serine metabolic process (GO:0006563)2.93263624
35regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92852968
36DNA strand renaturation (GO:0000733)2.91766390
37CENP-A containing nucleosome assembly (GO:0034080)2.88414785
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.84210486
39regulation of sister chromatid cohesion (GO:0007063)2.81887983
40ganglion development (GO:0061548)2.79863325
41negative regulation of histone methylation (GO:0031061)2.79264196
42non-recombinational repair (GO:0000726)2.72033014
43double-strand break repair via nonhomologous end joining (GO:0006303)2.72033014
44ATP-dependent chromatin remodeling (GO:0043044)2.71031404
45mitotic recombination (GO:0006312)2.70516939
46kinetochore organization (GO:0051383)2.70378850
47protein localization to chromosome (GO:0034502)2.69363246
48regulation of translational fidelity (GO:0006450)2.68606991
49telomere maintenance via recombination (GO:0000722)2.68571745
50DNA duplex unwinding (GO:0032508)2.67062087
51negative regulation of organelle assembly (GO:1902116)2.66775710
52DNA geometric change (GO:0032392)2.66421432
53translesion synthesis (GO:0019985)2.65154622
54nucleotide-excision repair, DNA gap filling (GO:0006297)2.64637645
55dosage compensation (GO:0007549)2.64600190
56corticosteroid receptor signaling pathway (GO:0031958)2.64159147
57mitotic sister chromatid segregation (GO:0000070)2.63352769
58spliceosomal tri-snRNP complex assembly (GO:0000244)2.62008596
59regulation of translational termination (GO:0006449)2.60989187
60DNA replication-independent nucleosome organization (GO:0034724)2.60778803
61DNA replication-independent nucleosome assembly (GO:0006336)2.60778803
62histone arginine methylation (GO:0034969)2.60234736
63glutamate secretion (GO:0014047)2.57498853
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57193591
65mitotic metaphase plate congression (GO:0007080)2.56864858
66mitotic cytokinesis (GO:0000281)2.56023716
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.55370494
68pore complex assembly (GO:0046931)2.54642560
69positive regulation of RNA splicing (GO:0033120)2.53482442
70mitotic chromosome condensation (GO:0007076)2.53159901
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51539045
72NLS-bearing protein import into nucleus (GO:0006607)2.51358075
73DNA conformation change (GO:0071103)2.48768663
74nucleobase biosynthetic process (GO:0046112)2.48140257
75negative regulation of DNA repair (GO:0045738)2.47893854
76negative regulation of mRNA processing (GO:0050686)2.47722959
77replication fork processing (GO:0031297)2.47508208
78axonal fasciculation (GO:0007413)2.47436541
79DNA replication-dependent nucleosome assembly (GO:0006335)2.46519554
80DNA replication-dependent nucleosome organization (GO:0034723)2.46519554
81chromatin assembly or disassembly (GO:0006333)2.46450119
82positive regulation of dendrite morphogenesis (GO:0050775)2.45965336
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45355682
84cell migration in hindbrain (GO:0021535)2.44855500
85mRNA splice site selection (GO:0006376)2.44810996
86positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.44196675
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43680488
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43603908
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.43603908
90regulation of DNA endoreduplication (GO:0032875)2.42417114
91positive regulation of chromosome segregation (GO:0051984)2.42310564
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.41872612
93regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.41378907
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40695543
95axon extension involved in axon guidance (GO:0048846)2.40519001
96neuron projection extension involved in neuron projection guidance (GO:1902284)2.40519001
97positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.40332123
98positive regulation of cell cycle G2/M phase transition (GO:1902751)2.40332123
99metaphase plate congression (GO:0051310)2.40169179
100nucleus localization (GO:0051647)2.39643739
101histone exchange (GO:0043486)2.39371089
102DNA replication (GO:0006260)2.39139515
103nuclear envelope disassembly (GO:0051081)2.38701419
104membrane disassembly (GO:0030397)2.38701419
105negative regulation of RNA splicing (GO:0033119)2.38277698
106cytoskeleton-dependent cytokinesis (GO:0061640)2.37817338
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.37348097
108alternative mRNA splicing, via spliceosome (GO:0000380)2.37042625
109dendritic spine morphogenesis (GO:0060997)2.37009536
110mitotic nuclear envelope disassembly (GO:0007077)2.36860717
111regulation of RNA export from nucleus (GO:0046831)2.36833209
112glial cell proliferation (GO:0014009)2.36515103
113chromosome segregation (GO:0007059)2.35691639
114viral mRNA export from host cell nucleus (GO:0046784)2.35591772
115body morphogenesis (GO:0010171)2.34848078
116notochord development (GO:0030903)2.34026141
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.33397040
118synaptic vesicle exocytosis (GO:0016079)2.32060774
119regulation of glutamate receptor signaling pathway (GO:1900449)2.31895604
120regulation of NFAT protein import into nucleus (GO:0051532)2.31756053
121chromatin assembly (GO:0031497)2.31736653
122regulation of centrosome duplication (GO:0010824)2.30844254
123histone H3-K9 demethylation (GO:0033169)2.30045696
124outer ear morphogenesis (GO:0042473)2.29684491
125lysine metabolic process (GO:0006553)2.29300108
126lysine catabolic process (GO:0006554)2.29300108
127regulation of DNA damage checkpoint (GO:2000001)2.29209930
128cerebellar Purkinje cell layer development (GO:0021680)2.29149030
129gastrulation with mouth forming second (GO:0001702)2.28657839
130negative regulation of mRNA metabolic process (GO:1903312)2.28110706
131mitotic G1 DNA damage checkpoint (GO:0031571)2.28014770
132vocalization behavior (GO:0071625)2.27975879
133cerebral cortex development (GO:0021987)2.27749177
134regulation of centrosome cycle (GO:0046605)2.27460941
135proline transport (GO:0015824)2.27233635
136convergent extension (GO:0060026)2.25975278
137DNA synthesis involved in DNA repair (GO:0000731)2.25524365
138kinetochore assembly (GO:0051382)2.24101479
139regulation of synaptic vesicle exocytosis (GO:2000300)2.23507212
140dendrite morphogenesis (GO:0048813)2.23083931
141chromosome condensation (GO:0030261)2.21588365
142DNA ligation (GO:0006266)2.21440044
143postreplication repair (GO:0006301)2.19791837
144mitotic cell cycle (GO:0000278)2.18993324
145protein-DNA complex disassembly (GO:0032986)2.18746688
146nucleosome disassembly (GO:0006337)2.18746688
147regulation of chromosome segregation (GO:0051983)2.18479514
148DNA topological change (GO:0006265)2.17981243
149pyrimidine nucleobase catabolic process (GO:0006208)2.17060294
150activation of protein kinase A activity (GO:0034199)2.16893868
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.16801279
152negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.16680516
153spindle checkpoint (GO:0031577)2.16663998
154nuclear envelope organization (GO:0006998)2.16525560
155IMP biosynthetic process (GO:0006188)2.16200137
156regulation of histone H3-K9 methylation (GO:0051570)2.15356665
157regulation of mitotic spindle organization (GO:0060236)2.15162245
158proximal/distal pattern formation (GO:0009954)2.15113268
159telomere maintenance via telomere lengthening (GO:0010833)2.15051979
160mitotic spindle organization (GO:0007052)2.14934712
161generation of neurons (GO:0048699)2.14333743
162establishment of mitotic spindle localization (GO:0040001)2.12789775
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.11182374
164spindle assembly (GO:0051225)2.10667521
165regulation of translation, ncRNA-mediated (GO:0045974)2.10624983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30924012
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.55039499
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.13443244
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86469676
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.84526942
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.82333255
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79025849
8EZH2_22144423_ChIP-Seq_EOC_Human2.75870239
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69921752
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.63953456
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.45443752
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30339642
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29262943
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21520647
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.18651348
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.17994775
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15689442
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13146707
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12896934
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10770679
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.09868946
22* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02787637
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87267816
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.86748755
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81340014
26XRN2_22483619_ChIP-Seq_HELA_Human1.78778117
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77210290
28MYC_22102868_ChIP-Seq_BL_Human1.75419506
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74505326
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74178232
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73688978
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.69065583
33AR_21909140_ChIP-Seq_LNCAP_Human1.66841673
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64782285
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63768436
36* TTF2_22483619_ChIP-Seq_HELA_Human1.57765221
37* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57024969
38* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55995710
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47157933
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46588426
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.45766282
42* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42765880
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42567975
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40764094
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.38919739
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37964091
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37192137
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36081244
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34132229
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32365160
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31869149
52FUS_26573619_Chip-Seq_HEK293_Human1.30722571
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30284488
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29774545
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27885955
56KDM5A_27292631_Chip-Seq_BREAST_Human1.27735024
57ELK1_19687146_ChIP-ChIP_HELA_Human1.27528755
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.27289172
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26068979
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25799833
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25761721
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.24448689
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22985490
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22375530
65EWS_26573619_Chip-Seq_HEK293_Human1.21074012
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.20954967
67CIITA_25753668_ChIP-Seq_RAJI_Human1.20483013
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.20433469
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20228960
70MYC_18940864_ChIP-ChIP_HL60_Human1.19945499
71DROSHA_22980978_ChIP-Seq_HELA_Human1.19724115
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.19647330
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.18550918
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17838752
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17451922
76POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16843348
77DCP1A_22483619_ChIP-Seq_HELA_Human1.16748149
78KDM2B_26808549_Chip-Seq_K562_Human1.16440729
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15927003
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14789973
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14789973
82KDM2B_26808549_Chip-Seq_DND41_Human1.13619891
83* GABP_19822575_ChIP-Seq_HepG2_Human1.12875690
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12749669
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.12147276
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.10297196
87* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09972418
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09076181
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07852851
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.06769278
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05940453
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05829511
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05694950
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04720372
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.03610137
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02537819
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02231885
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01869191
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01673903
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99950717
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.98770070
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98689741
103JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97616650
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.96810177
105* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96567964
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95760696
107IGF1R_20145208_ChIP-Seq_DFB_Human0.95490403
108TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94658450
109* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94169259
110TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93960834
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.93856872
112ZNF274_21170338_ChIP-Seq_K562_Hela0.92973640
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92502123
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92250462
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91945866
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91856190
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91805002
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91350957
119REST_21632747_ChIP-Seq_MESCs_Mouse0.91102315
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90713111
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90080036
122AR_19668381_ChIP-Seq_PC3_Human0.89895969
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89719588
124TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89582945
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.89239465
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89224716
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88896996
128SOX9_26525672_Chip-Seq_HEART_Mouse0.88827986
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88570733
130THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88088793
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88034898
132CLOCK_20551151_ChIP-Seq_293T_Human0.87916631
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87815142
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.87334101
135* CHD1_26751641_Chip-Seq_LNCaP_Human0.86201769
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85760375
137GBX2_23144817_ChIP-Seq_PC3_Human0.84222162
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84035368
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83479133
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82910793
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81398144
142NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80164729
143* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79192173
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.77756793
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.76984081
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75537687
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73046593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.21348085
2MP0003123_paternal_imprinting3.02750695
3MP0000569_abnormal_digit_pigmentation2.87691923
4MP0003122_maternal_imprinting2.81268452
5MP0003121_genomic_imprinting2.65330230
6MP0008057_abnormal_DNA_replication2.50699333
7MP0003136_yellow_coat_color2.49441126
8MP0003693_abnormal_embryo_hatching2.43551973
9MP0000537_abnormal_urethra_morphology2.38029614
10MP0010030_abnormal_orbit_morphology2.25293435
11MP0005171_absent_coat_pigmentation2.17427220
12MP0008058_abnormal_DNA_repair2.11971795
13MP0003705_abnormal_hypodermis_morpholog2.08916514
14MP0010352_gastrointestinal_tract_polyps2.05349226
15MP0003787_abnormal_imprinting2.04837904
16MP0005623_abnormal_meninges_morphology1.99045585
17MP0000566_synostosis1.97115084
18MP0010094_abnormal_chromosome_stability1.91981184
19MP0003283_abnormal_digestive_organ1.87961316
20MP0003111_abnormal_nucleus_morphology1.83355720
21MP0005076_abnormal_cell_differentiation1.82550836
22MP0004233_abnormal_muscle_weight1.82008568
23MP0003635_abnormal_synaptic_transmissio1.75424544
24MP0008438_abnormal_cutaneous_collagen1.72860637
25MP0003385_abnormal_body_wall1.71026023
26MP0001346_abnormal_lacrimal_gland1.65731796
27MP0004197_abnormal_fetal_growth/weight/1.61883448
28MP0002938_white_spotting1.60886879
29MP0006292_abnormal_olfactory_placode1.58347190
30MP0000534_abnormal_ureter_morphology1.56910256
31MP0001730_embryonic_growth_arrest1.49470311
32MP0002084_abnormal_developmental_patter1.49219182
33MP0003077_abnormal_cell_cycle1.47093784
34MP0003890_abnormal_embryonic-extraembry1.46341340
35MP0003942_abnormal_urinary_system1.44559674
36MP0005187_abnormal_penis_morphology1.41900737
37MP0009053_abnormal_anal_canal1.41007523
38MP0003119_abnormal_digestive_system1.40533730
39MP0000428_abnormal_craniofacial_morphol1.39475861
40MP0008789_abnormal_olfactory_epithelium1.38434135
41MP0003115_abnormal_respiratory_system1.37800642
42MP0002233_abnormal_nose_morphology1.37631394
43MP0003861_abnormal_nervous_system1.37531928
44MP0002063_abnormal_learning/memory/cond1.36860453
45MP0010307_abnormal_tumor_latency1.33261155
46MP0000778_abnormal_nervous_system1.31634270
47MP0002085_abnormal_embryonic_tissue1.31471082
48MP0004811_abnormal_neuron_physiology1.30724518
49MP0008007_abnormal_cellular_replicative1.30534961
50MP0001286_abnormal_eye_development1.30161043
51MP0000350_abnormal_cell_proliferation1.27743609
52MP0000733_abnormal_muscle_development1.24750075
53MP0001697_abnormal_embryo_size1.24366832
54MP0003315_abnormal_perineum_morphology1.23226651
55MP0001672_abnormal_embryogenesis/_devel1.23074390
56MP0005380_embryogenesis_phenotype1.23074390
57MP0005503_abnormal_tendon_morphology1.20858583
58MP0003937_abnormal_limbs/digits/tail_de1.18560274
59MP0001299_abnormal_eye_distance/1.17861755
60MP0003938_abnormal_ear_development1.17771114
61MP0003935_abnormal_craniofacial_develop1.17592659
62MP0004270_analgesia1.17184976
63MP0009703_decreased_birth_body1.16224930
64MP0002751_abnormal_autonomic_nervous1.16164812
65MP0004957_abnormal_blastocyst_morpholog1.14879710
66MP0003984_embryonic_growth_retardation1.11798703
67MP0002088_abnormal_embryonic_growth/wei1.11480908
68MP0001188_hyperpigmentation1.10655707
69MP0002653_abnormal_ependyma_morphology1.10636505
70MP0009672_abnormal_birth_weight1.10096943
71MP0009780_abnormal_chondrocyte_physiolo1.09704070
72MP0002152_abnormal_brain_morphology1.09207700
73MP0001529_abnormal_vocalization1.08839072
74MP0002092_abnormal_eye_morphology1.07962152
75MP0000049_abnormal_middle_ear1.07024141
76MP0002086_abnormal_extraembryonic_tissu1.06814529
77MP0003755_abnormal_palate_morphology1.05363515
78MP0005423_abnormal_somatic_nervous1.04568017
79MP0008877_abnormal_DNA_methylation1.03981513
80MP0002249_abnormal_larynx_morphology1.03662134
81MP0005391_vision/eye_phenotype1.02724615
82MP0002081_perinatal_lethality1.02059604
83MP0002877_abnormal_melanocyte_morpholog1.01835984
84MP0002638_abnormal_pupillary_reflex1.01557559
85MP0002080_prenatal_lethality1.00707288
86MP0002184_abnormal_innervation0.99148501
87MP0001849_ear_inflammation0.98262415
88MP0004858_abnormal_nervous_system0.97508490
89MP0000579_abnormal_nail_morphology0.97352619
90MP0002116_abnormal_craniofacial_bone0.96740882
91MP0009697_abnormal_copulation0.95859403
92MP0000647_abnormal_sebaceous_gland0.95540074
93MP0001293_anophthalmia0.95474730
94MP0000955_abnormal_spinal_cord0.95438593
95MP0009745_abnormal_behavioral_response0.94704583
96MP0005499_abnormal_olfactory_system0.94416653
97MP0005394_taste/olfaction_phenotype0.94416653
98MP0010234_abnormal_vibrissa_follicle0.93874627
99MP0004133_heterotaxia0.93870341
100MP0008932_abnormal_embryonic_tissue0.93124132
101MP0009046_muscle_twitch0.92457328
102MP0000516_abnormal_urinary_system0.91904181
103MP0005367_renal/urinary_system_phenotyp0.91904181
104MP0005253_abnormal_eye_physiology0.91728445
105MP0005174_abnormal_tail_pigmentation0.90159464
106MP0002234_abnormal_pharynx_morphology0.89477798
107MP0002572_abnormal_emotion/affect_behav0.89213235
108MP0002102_abnormal_ear_morphology0.88984946
109MP0002064_seizures0.88590860
110MP0002089_abnormal_postnatal_growth/wei0.88466929
111MP0002932_abnormal_joint_morphology0.88252490
112MP0002114_abnormal_axial_skeleton0.87510551
113MP0009250_abnormal_appendicular_skeleto0.87112320
114MP0002925_abnormal_cardiovascular_devel0.86107607
115MP0003880_abnormal_central_pattern0.85511802
116MP0002697_abnormal_eye_size0.85491832
117MP0000013_abnormal_adipose_tissue0.85265045
118MP0003943_abnormal_hepatobiliary_system0.85209363
119MP0000003_abnormal_adipose_tissue0.84623010
120MP0000631_abnormal_neuroendocrine_gland0.84513473
121MP0000432_abnormal_head_morphology0.83538804
122MP0004272_abnormal_basement_membrane0.82693460
123MP0002111_abnormal_tail_morphology0.82646556
124MP0002882_abnormal_neuron_morphology0.82381768
125MP0001348_abnormal_lacrimal_gland0.81945416
126MP0003567_abnormal_fetal_cardiomyocyte0.81777619
127MP0003718_maternal_effect0.81362571
128MP0005409_darkened_coat_color0.80806364
129MP0008770_decreased_survivor_rate0.79934197
130MP0006054_spinal_hemorrhage0.79931734
131MP0005257_abnormal_intraocular_pressure0.79524706
132MP0004885_abnormal_endolymph0.79025505
133MP0001177_atelectasis0.78879258
134MP0006072_abnormal_retinal_apoptosis0.78574501
135MP0002752_abnormal_somatic_nervous0.76466057
136MP0005197_abnormal_uvea_morphology0.75962499

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.88223769
2Chromsome breakage (HP:0040012)3.62005407
3Short 4th metacarpal (HP:0010044)3.56613786
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56613786
5Shallow orbits (HP:0000586)3.07109397
6Abnormality of the astrocytes (HP:0100707)3.06880253
7Astrocytoma (HP:0009592)3.06880253
8Birth length less than 3rd percentile (HP:0003561)2.96659156
9Renal duplication (HP:0000075)2.95466087
10Patellar aplasia (HP:0006443)2.93641626
11Abnormality of cochlea (HP:0000375)2.87227317
12Ependymoma (HP:0002888)2.86459221
13Hyperacusis (HP:0010780)2.83495391
14Abnormality of the 4th metacarpal (HP:0010012)2.79171474
15Cortical dysplasia (HP:0002539)2.76927544
16Pointed chin (HP:0000307)2.70478306
17Aplasia/Hypoplasia of the patella (HP:0006498)2.66463755
18Bowel diverticulosis (HP:0005222)2.66199134
19Meckel diverticulum (HP:0002245)2.59706554
20Morphological abnormality of the inner ear (HP:0011390)2.56686896
21Abnormality of the lower motor neuron (HP:0002366)2.51161199
22High anterior hairline (HP:0009890)2.48999750
23Abnormality of the ileum (HP:0001549)2.48475274
24Ectopic kidney (HP:0000086)2.46897548
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.45778593
26Increased nuchal translucency (HP:0010880)2.39116524
27Glioma (HP:0009733)2.38408088
28Protrusio acetabuli (HP:0003179)2.34433592
29Renovascular hypertension (HP:0100817)2.33959805
30Absent radius (HP:0003974)2.32387577
31Macroorchidism (HP:0000053)2.30395191
32Elfin facies (HP:0004428)2.30377584
33Abnormality of the labia minora (HP:0012880)2.29771793
34Insomnia (HP:0100785)2.26736591
35Rib fusion (HP:0000902)2.26482810
36Abnormality of the carotid arteries (HP:0005344)2.25487068
37Facial cleft (HP:0002006)2.24243386
38Absent forearm bone (HP:0003953)2.21815590
39Aplasia involving forearm bones (HP:0009822)2.21815590
40Volvulus (HP:0002580)2.20721579
41Medulloblastoma (HP:0002885)2.13397978
42Cerebral aneurysm (HP:0004944)2.11188901
43Broad distal phalanx of finger (HP:0009836)2.07871386
44Coronal craniosynostosis (HP:0004440)2.06561844
45Esophageal atresia (HP:0002032)2.06092784
46Bladder diverticulum (HP:0000015)2.05885969
47Overriding aorta (HP:0002623)2.04685563
48Abnormality of chromosome stability (HP:0003220)2.04405227
49Obsessive-compulsive behavior (HP:0000722)2.04017134
50Breast hypoplasia (HP:0003187)2.01913584
51Facial hemangioma (HP:0000329)2.01870191
52Ankle contracture (HP:0006466)2.01231982
53Ankyloglossia (HP:0010296)2.00930811
54Flat cornea (HP:0007720)1.99948733
55Shoulder girdle muscle weakness (HP:0003547)1.98808346
56Neoplasm of the heart (HP:0100544)1.98600960
57Abnormal number of incisors (HP:0011064)1.97572293
5811 pairs of ribs (HP:0000878)1.96488866
59Insidious onset (HP:0003587)1.96255445
60Termporal pattern (HP:0011008)1.96255445
61Deep philtrum (HP:0002002)1.95260320
62Colon cancer (HP:0003003)1.94030260
63Aplasia/Hypoplasia of the sternum (HP:0006714)1.93673738
64Genu recurvatum (HP:0002816)1.93421280
65Trigonocephaly (HP:0000243)1.93199299
66Wrist flexion contracture (HP:0001239)1.93059339
67Sacral dimple (HP:0000960)1.92132944
68Chin dimple (HP:0010751)1.91507329
69Calcaneovalgus deformity (HP:0001848)1.90273975
70Overlapping toe (HP:0001845)1.88220649
71Resting tremor (HP:0002322)1.87650753
72Aqueductal stenosis (HP:0002410)1.87477312
73Annular pancreas (HP:0001734)1.87253796
74Abnormality of the calcaneus (HP:0008364)1.86718650
75Abnormality of oral frenula (HP:0000190)1.86472262
76Enlarged penis (HP:0000040)1.85912806
77Poikiloderma (HP:0001029)1.85611239
78Abnormality of the preputium (HP:0100587)1.84463497
79Broad metatarsal (HP:0001783)1.83457474
80Partial agenesis of the corpus callosum (HP:0001338)1.83025062
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82030318
82Focal seizures (HP:0007359)1.81909186
83Diastasis recti (HP:0001540)1.80369780
84Fibrous tissue neoplasm (HP:0012316)1.80316099
85Fibroma (HP:0010614)1.79593129
86Impaired vibration sensation in the lower limbs (HP:0002166)1.79271637
87Broad thumb (HP:0011304)1.79258435
88Spinal cord lesions (HP:0100561)1.78953205
89Syringomyelia (HP:0003396)1.78953205
90Drooling (HP:0002307)1.77413591
91Small intestinal stenosis (HP:0012848)1.77393273
92Duodenal stenosis (HP:0100867)1.77393273
93Cutaneous finger syndactyly (HP:0010554)1.77369204
94Abnormal lung lobation (HP:0002101)1.77211882
95Deviation of the hallux (HP:0010051)1.76581654
96Anophthalmia (HP:0000528)1.75265860
97Bifid tongue (HP:0010297)1.74661041
98Selective tooth agenesis (HP:0001592)1.74314126
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74043425
100Absent epiphyses (HP:0010577)1.74043425
101Tracheomalacia (HP:0002779)1.74033120
102Abnormality of the duodenum (HP:0002246)1.73697458
103Pelvic girdle muscle weakness (HP:0003749)1.73485341
104Hypoplasia of the maxilla (HP:0000327)1.72152667
105Neoplasm of striated muscle (HP:0009728)1.69876876
106Hallux valgus (HP:0001822)1.69683233
107Triphalangeal thumb (HP:0001199)1.69558282
108Preaxial hand polydactyly (HP:0001177)1.69148380
109Dilatation of the ascending aorta (HP:0005111)1.69131985
110Heterotopia (HP:0002282)1.68974699
111Missing ribs (HP:0000921)1.68406218
112Malignant neoplasm of the central nervous system (HP:0100836)1.67767901
113Absent frontal sinuses (HP:0002688)1.67083570
114Duplication of thumb phalanx (HP:0009942)1.66818084
115Turricephaly (HP:0000262)1.66597395
116Spina bifida occulta (HP:0003298)1.66435077
117Abnormality of chromosome segregation (HP:0002916)1.65686074
118Hepatoblastoma (HP:0002884)1.64629279
119Buphthalmos (HP:0000557)1.63474972
120Short thumb (HP:0009778)1.63016802
121Intestinal atresia (HP:0011100)1.62183795
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62038501
123Gastrointestinal atresia (HP:0002589)1.61954669
124Broad phalanges of the hand (HP:0009768)1.61564691
125Visual hallucinations (HP:0002367)1.61559408
126Subacute progressive viral hepatitis (HP:0006572)1.61519757
127Asymmetry of the thorax (HP:0001555)1.61475523
128Abnormality of the septum pellucidum (HP:0007375)1.60994161
129Increased density of long bones (HP:0006392)1.60631950
130Megalocornea (HP:0000485)1.60615557
131Nervous tissue neoplasm (HP:0030060)1.59920563
132Neuroectodermal neoplasm (HP:0030061)1.59920563
133Neuroepithelial neoplasm (HP:0030063)1.59920563
134Absent septum pellucidum (HP:0001331)1.59770333
135Neoplasm of the oral cavity (HP:0100649)1.59336185
136Abnormality of the diencephalon (HP:0010662)1.59117276
137Narrow palate (HP:0000189)1.58636799
138Hemivertebrae (HP:0002937)1.58416866
139Deformed tarsal bones (HP:0008119)1.58136376
140Cutaneous syndactyly (HP:0012725)1.57781297
141Lymphangioma (HP:0100764)1.57089266
142Distal upper limb amyotrophy (HP:0007149)1.56844407
143Upper limb amyotrophy (HP:0009129)1.56844407
144Dysmetric saccades (HP:0000641)1.56762943
145Atonic seizures (HP:0010819)1.56308321
146Freckling (HP:0001480)1.55499499
147Deviation of the thumb (HP:0009603)1.55231575
148Septo-optic dysplasia (HP:0100842)1.54735308
149Oligodactyly (HP:0012165)1.54037593
150Hypopigmentation of the fundus (HP:0007894)1.53821308
151Broad palm (HP:0001169)1.53758562
152Deep palmar crease (HP:0006191)1.53632159
153Abnormality of the hip-girdle musculature (HP:0001445)1.53609295
154Abnormality of the musculature of the pelvis (HP:0001469)1.53609295
155Broad finger (HP:0001500)1.53515581
156Hand muscle atrophy (HP:0009130)1.53509643
157Microtia (HP:0008551)1.52862080
158Abnormality of the intervertebral disk (HP:0005108)1.52132641
159Sloping forehead (HP:0000340)1.52043498
160Broad long bones (HP:0005622)1.51717177
161Horseshoe kidney (HP:0000085)1.51468361
162Rhabdomyosarcoma (HP:0002859)1.51103396
163Urinary bladder sphincter dysfunction (HP:0002839)1.50932190
164Choanal atresia (HP:0000453)1.50901596
165Broad phalanx (HP:0006009)1.50245333
166Shawl scrotum (HP:0000049)1.50241791
167Neuroblastic tumors (HP:0004376)1.50219701
168Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.50219701
169Neuroblastoma (HP:0003006)1.50219701
170Primitive neuroectodermal tumor (HP:0030065)1.50219701
171Short 1st metacarpal (HP:0010034)1.50024884
172Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.50024884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.20209068
2SRPK12.95167279
3STK38L2.75726759
4NEK12.52641743
5BRSK22.43462888
6CDK122.40448881
7EEF2K2.24058975
8PBK2.20833751
9BUB12.16132027
10PAK62.15162484
11LATS22.06423761
12CASK2.04819184
13PDGFRA2.04812392
14KSR11.97812114
15PKN21.95363350
16NTRK31.84985444
17TRIB31.84657174
18MAP3K41.75617559
19MARK11.71025668
20MINK11.64120841
21PRKD31.62962415
22EIF2AK11.62901079
23TSSK61.62498598
24LATS11.59758874
25TYRO31.58449153
26SCYL21.56784442
27DDR21.52670299
28KSR21.51130219
29NEK21.49502748
30MAP3K101.48774696
31ALK1.44282645
32TTN1.43046598
33TAF11.40309719
34MAP3K91.39749330
35PLK41.34367614
36DYRK21.30506805
37PASK1.26211124
38CAMKK11.23847772
39BCR1.22238946
40PLK31.21282017
41EPHA41.20904383
42PLK21.20474473
43TNIK1.20336766
44MKNK11.17699444
45FGFR21.17239955
46FGFR11.13312776
47BRD41.11975692
48DAPK11.10970539
49UHMK11.08046458
50CAMK1G1.07774818
51TTK1.05911130
52PNCK1.05755531
53BRSK11.04720016
54WNK11.03941346
55NTRK11.03897151
56NTRK21.03869111
57ZAK1.03290831
58TRIM281.02821675
59CSNK1A1L1.00782126
60ATR0.99904667
61AKT30.99499402
62DAPK20.99397729
63ERBB30.99193077
64MTOR0.98756703
65BMPR1B0.98253446
66MET0.97507618
67ICK0.97212578
68DYRK30.96944476
69RIPK10.95192432
70CSNK1G10.94929672
71CDK180.93752152
72CDK30.93658711
73TGFBR10.93376871
74CDK150.93157930
75PTK60.92967648
76PAK40.92554971
77CSNK1G30.92163526
78PAK20.91760963
79CHEK10.91675857
80WEE10.90893091
81PAK30.90408735
82STK380.88613769
83VRK20.88507409
84CAMK1D0.87387491
85BMX0.86899747
86WNK30.86146780
87CDK140.84850415
88CSNK1G20.81460416
89WNK40.79904906
90RET0.79900059
91CCNB10.78651787
92CDK11A0.78206536
93CDK20.77505437
94CDC42BPA0.76750438
95SIK20.76606867
96SGK30.75482883
97CDK60.75462730
98EPHB20.74914564
99MAP2K70.74348838
100CDK10.73269080
101PLK10.72432631
102MAP3K80.71038755
103PDGFRB0.70486508
104CDK50.69204059
105ATM0.68797541
106CDK80.67281590
107MAP2K40.67049231
108FER0.63819020
109PRKDC0.61622174
110CSNK1E0.58556969
111FLT30.58320974
112ERBB40.58197557
113RPS6KA20.58169264
114MAPK100.58167671
115CDK70.57726023
116AURKA0.57473478
117PRPF4B0.56811138
118CHEK20.56689177
119AKT20.55077424
120PRKCH0.52905992
121MKNK20.52480212
122STK30.52376250
123SGK20.51421031
124GSK3B0.51356411
125ERBB20.50587581
126CSNK1D0.50352878
127RPS6KA40.49616347
128CDK40.49063447
129AURKB0.48162228
130RAF10.48111438
131PTK20.47421562
132MAPK140.46756773
133EPHA30.46552410
134LIMK10.44802649
135STK160.44510865
136VRK10.38571740

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.88580386
2Fanconi anemia pathway_Homo sapiens_hsa034602.78701503
3Homologous recombination_Homo sapiens_hsa034402.32962673
4RNA polymerase_Homo sapiens_hsa030201.94554966
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82379612
6Long-term potentiation_Homo sapiens_hsa047201.76334137
7Oocyte meiosis_Homo sapiens_hsa041141.75911684
8Cell cycle_Homo sapiens_hsa041101.69370744
9Nicotine addiction_Homo sapiens_hsa050331.68258375
10DNA replication_Homo sapiens_hsa030301.63745362
11Glioma_Homo sapiens_hsa052141.61815178
12Synaptic vesicle cycle_Homo sapiens_hsa047211.60767904
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58296641
14mRNA surveillance pathway_Homo sapiens_hsa030151.53964486
15Circadian entrainment_Homo sapiens_hsa047131.46285515
16Mismatch repair_Homo sapiens_hsa034301.45875063
17Colorectal cancer_Homo sapiens_hsa052101.45705888
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45487910
19Endometrial cancer_Homo sapiens_hsa052131.44808289
20Hippo signaling pathway_Homo sapiens_hsa043901.43011662
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42926027
22Gap junction_Homo sapiens_hsa045401.42249014
23RNA transport_Homo sapiens_hsa030131.40315692
24Biosynthesis of amino acids_Homo sapiens_hsa012301.39265069
25Basal transcription factors_Homo sapiens_hsa030221.38505270
26mTOR signaling pathway_Homo sapiens_hsa041501.36188635
27Basal cell carcinoma_Homo sapiens_hsa052171.33330218
28Hedgehog signaling pathway_Homo sapiens_hsa043401.31800980
29Dopaminergic synapse_Homo sapiens_hsa047281.29990503
30GABAergic synapse_Homo sapiens_hsa047271.29208612
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27104316
32Selenocompound metabolism_Homo sapiens_hsa004501.26159072
33Amphetamine addiction_Homo sapiens_hsa050311.25997681
34Olfactory transduction_Homo sapiens_hsa047401.25996732
35MicroRNAs in cancer_Homo sapiens_hsa052061.25479730
36Estrogen signaling pathway_Homo sapiens_hsa049151.24856217
37Non-small cell lung cancer_Homo sapiens_hsa052231.24765623
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24302834
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23969670
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21937928
41Glutamatergic synapse_Homo sapiens_hsa047241.21823924
42Pyrimidine metabolism_Homo sapiens_hsa002401.20559328
43Axon guidance_Homo sapiens_hsa043601.19862249
44Chronic myeloid leukemia_Homo sapiens_hsa052201.19526289
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19407948
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.18530089
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.18508692
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18401068
49Proteoglycans in cancer_Homo sapiens_hsa052051.17735571
50Morphine addiction_Homo sapiens_hsa050321.17041936
51Spliceosome_Homo sapiens_hsa030401.16890969
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12898919
53RNA degradation_Homo sapiens_hsa030181.12532256
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12261022
55Oxytocin signaling pathway_Homo sapiens_hsa049211.12173194
56Melanogenesis_Homo sapiens_hsa049161.12097736
57GnRH signaling pathway_Homo sapiens_hsa049121.11646571
58Steroid biosynthesis_Homo sapiens_hsa001001.11172939
59Cholinergic synapse_Homo sapiens_hsa047251.10123542
60ErbB signaling pathway_Homo sapiens_hsa040121.09362175
61Sulfur relay system_Homo sapiens_hsa041221.09044269
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08403715
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.07919273
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07774733
65Wnt signaling pathway_Homo sapiens_hsa043101.07636316
66Long-term depression_Homo sapiens_hsa047301.07474683
67Alcoholism_Homo sapiens_hsa050341.06703100
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05812779
69Adherens junction_Homo sapiens_hsa045201.05204831
70Insulin secretion_Homo sapiens_hsa049111.04415446
71Focal adhesion_Homo sapiens_hsa045101.03745825
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03698778
73Bladder cancer_Homo sapiens_hsa052190.99862533
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96157862
75Type II diabetes mellitus_Homo sapiens_hsa049300.96106228
76Pyruvate metabolism_Homo sapiens_hsa006200.95478636
77Gastric acid secretion_Homo sapiens_hsa049710.93604560
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91701323
79Salivary secretion_Homo sapiens_hsa049700.89634167
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89399349
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89362620
82Dilated cardiomyopathy_Homo sapiens_hsa054140.87087049
83Thyroid cancer_Homo sapiens_hsa052160.86561422
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86179960
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85804341
86Melanoma_Homo sapiens_hsa052180.84957044
87Renal cell carcinoma_Homo sapiens_hsa052110.84871639
88Rap1 signaling pathway_Homo sapiens_hsa040150.84722629
89Base excision repair_Homo sapiens_hsa034100.82361509
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81857812
91Purine metabolism_Homo sapiens_hsa002300.81591143
92Tight junction_Homo sapiens_hsa045300.81255260
93Nucleotide excision repair_Homo sapiens_hsa034200.79769723
94Renin secretion_Homo sapiens_hsa049240.79665594
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79629640
96HTLV-I infection_Homo sapiens_hsa051660.79358816
97One carbon pool by folate_Homo sapiens_hsa006700.79352369
98Dorso-ventral axis formation_Homo sapiens_hsa043200.78289183
99Viral carcinogenesis_Homo sapiens_hsa052030.77510296
100Cocaine addiction_Homo sapiens_hsa050300.77494559
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76959242
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76392612
103MAPK signaling pathway_Homo sapiens_hsa040100.75747344
104Insulin signaling pathway_Homo sapiens_hsa049100.74727377
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74274668
106TGF-beta signaling pathway_Homo sapiens_hsa043500.74151630
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.73376471
108Proteasome_Homo sapiens_hsa030500.72612019
109Protein export_Homo sapiens_hsa030600.72351708
110VEGF signaling pathway_Homo sapiens_hsa043700.72240667
111Small cell lung cancer_Homo sapiens_hsa052220.71747468
112Notch signaling pathway_Homo sapiens_hsa043300.71616398
113Pancreatic cancer_Homo sapiens_hsa052120.70969059
114Lysine degradation_Homo sapiens_hsa003100.70683565
115Glucagon signaling pathway_Homo sapiens_hsa049220.70063485
116Pathways in cancer_Homo sapiens_hsa052000.69771249
117cAMP signaling pathway_Homo sapiens_hsa040240.69535664
118Prostate cancer_Homo sapiens_hsa052150.69399507
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69084062
120Vitamin B6 metabolism_Homo sapiens_hsa007500.67895041
121Taste transduction_Homo sapiens_hsa047420.67714686
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66357598
123Circadian rhythm_Homo sapiens_hsa047100.64742177
124N-Glycan biosynthesis_Homo sapiens_hsa005100.63974909
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62943530
126Choline metabolism in cancer_Homo sapiens_hsa052310.62467253
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62410502
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61260186
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60750380
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60722700
131p53 signaling pathway_Homo sapiens_hsa041150.58466147
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.58140084
133Carbon metabolism_Homo sapiens_hsa012000.55979857
134Propanoate metabolism_Homo sapiens_hsa006400.51521367
135ECM-receptor interaction_Homo sapiens_hsa045120.46005397
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44835370
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43340136
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42474367
139Phototransduction_Homo sapiens_hsa047440.41166617
140Butanoate metabolism_Homo sapiens_hsa006500.37218293
141Arginine and proline metabolism_Homo sapiens_hsa003300.29739405
142Nitrogen metabolism_Homo sapiens_hsa009100.27907686
143Fatty acid metabolism_Homo sapiens_hsa012120.27758906
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27211118
145Metabolic pathways_Homo sapiens_hsa011000.23849352

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