IPO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.73706763
2nuclear pore organization (GO:0006999)6.64600393
3pore complex assembly (GO:0046931)4.92352962
4DNA unwinding involved in DNA replication (GO:0006268)4.90298830
5folic acid-containing compound biosynthetic process (GO:0009396)4.81722293
6protein localization to kinetochore (GO:0034501)4.72762438
7regulation of translational termination (GO:0006449)4.57853999
8regulation of RNA export from nucleus (GO:0046831)4.56685833
9IMP biosynthetic process (GO:0006188)4.48766893
10mitotic sister chromatid cohesion (GO:0007064)4.47091447
11mitotic nuclear envelope disassembly (GO:0007077)4.46698000
12nuclear envelope disassembly (GO:0051081)4.31829663
13membrane disassembly (GO:0030397)4.31829663
14pre-miRNA processing (GO:0031054)4.29581506
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.26846091
16ribosome assembly (GO:0042255)4.18894551
17DNA replication-dependent nucleosome organization (GO:0034723)4.18550146
18DNA replication-dependent nucleosome assembly (GO:0006335)4.18550146
19regulation of translational fidelity (GO:0006450)4.16670954
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.07224623
21nucleobase biosynthetic process (GO:0046112)4.05536648
22IMP metabolic process (GO:0046040)4.01879628
23regulation of spindle organization (GO:0090224)4.00400086
24cellular protein complex localization (GO:0034629)3.95717758
25sister chromatid segregation (GO:0000819)3.94839016
26heterochromatin organization (GO:0070828)3.94699895
27positive regulation of chromosome segregation (GO:0051984)3.90172065
28mitotic metaphase plate congression (GO:0007080)3.85199523
29DNA duplex unwinding (GO:0032508)3.84084561
30DNA geometric change (GO:0032392)3.82619583
31regulation of histone H3-K9 methylation (GO:0051570)3.79943090
32chromatin assembly (GO:0031497)3.79567935
33mitotic chromosome condensation (GO:0007076)3.78992119
34protein complex localization (GO:0031503)3.77637529
35regulation of mitotic spindle organization (GO:0060236)3.76052230
36NLS-bearing protein import into nucleus (GO:0006607)3.73168881
37negative regulation of histone methylation (GO:0031061)3.72700380
38purine nucleobase biosynthetic process (GO:0009113)3.69602533
39protein localization to chromosome, centromeric region (GO:0071459)3.63144998
40regulation of nucleobase-containing compound transport (GO:0032239)3.62513700
41histone H2A monoubiquitination (GO:0035518)3.59225484
42regulation of posttranscriptional gene silencing (GO:0060147)3.56032625
43regulation of gene silencing by miRNA (GO:0060964)3.56032625
44regulation of gene silencing by RNA (GO:0060966)3.56032625
45establishment of integrated proviral latency (GO:0075713)3.55770637
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.53226304
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.53226304
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.53226304
49mitotic sister chromatid segregation (GO:0000070)3.52242876
50regulation of sister chromatid cohesion (GO:0007063)3.50089048
51nuclear envelope organization (GO:0006998)3.49895835
52dosage compensation (GO:0007549)3.48772733
53COPI coating of Golgi vesicle (GO:0048205)3.47720772
54Golgi transport vesicle coating (GO:0048200)3.47720772
55chaperone-mediated protein complex assembly (GO:0051131)3.47164223
56regulation of centrosome cycle (GO:0046605)3.45650952
57regulation of centriole replication (GO:0046599)3.40233382
58paraxial mesoderm development (GO:0048339)3.35406628
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.33429982
60regulation of DNA endoreduplication (GO:0032875)3.29298480
61negative regulation of DNA repair (GO:0045738)3.28860637
62metaphase plate congression (GO:0051310)3.28505841
63DNA replication initiation (GO:0006270)3.25680061
64chromosome condensation (GO:0030261)3.24428485
65RNA stabilization (GO:0043489)3.19767118
66mRNA stabilization (GO:0048255)3.19767118
67notochord development (GO:0030903)3.18483380
68spindle assembly involved in mitosis (GO:0090307)3.15236353
69monoubiquitinated protein deubiquitination (GO:0035520)3.11411965
70chromatin assembly or disassembly (GO:0006333)3.09719224
71protein export from nucleus (GO:0006611)3.08039193
72regulation of chromosome segregation (GO:0051983)3.04802622
73regulation of centrosome duplication (GO:0010824)3.03910863
74hemidesmosome assembly (GO:0031581)3.01555086
75histone-serine phosphorylation (GO:0035404)3.01309972
76positive regulation of SMAD protein import into nucleus (GO:0060391)3.01276436
77formation of translation preinitiation complex (GO:0001731)2.99965822
78microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.99810424
79regulation of helicase activity (GO:0051095)2.99410378
80peptidyl-lysine dimethylation (GO:0018027)2.99194606
81DNA strand elongation involved in DNA replication (GO:0006271)2.96635411
82protein K6-linked ubiquitination (GO:0085020)2.96421909
83spindle checkpoint (GO:0031577)2.96316798
84mitotic G1 DNA damage checkpoint (GO:0031571)2.92943962
85DNA strand elongation (GO:0022616)2.90229613
86DNA conformation change (GO:0071103)2.89888656
87tetrahydrofolate metabolic process (GO:0046653)2.87177953
88mitotic spindle checkpoint (GO:0071174)2.87080011
89protein localization to chromosome (GO:0034502)2.86928790
90folic acid metabolic process (GO:0046655)2.86927363
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86604537
92mRNA transport (GO:0051028)2.85895043
93protein localization to microtubule (GO:0035372)2.82268316
94desmosome organization (GO:0002934)2.81196602
95ribosome biogenesis (GO:0042254)2.80311965
96non-recombinational repair (GO:0000726)2.78523668
97double-strand break repair via nonhomologous end joining (GO:0006303)2.78523668
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77002546
99DNA packaging (GO:0006323)2.76714607
100mitotic cytokinesis (GO:0000281)2.76179063
101spindle assembly checkpoint (GO:0071173)2.76032561
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75908889
103translesion synthesis (GO:0019985)2.75671168
104hippo signaling (GO:0035329)2.75641972
105cell adhesion mediated by integrin (GO:0033627)2.74017252
106chromatin remodeling at centromere (GO:0031055)2.73696451
107glucocorticoid receptor signaling pathway (GO:0042921)2.72981111
108DNA replication-independent nucleosome assembly (GO:0006336)2.70174211
109DNA replication-independent nucleosome organization (GO:0034724)2.70174211
110negative regulation of chromosome segregation (GO:0051985)2.69877760
111adherens junction assembly (GO:0034333)2.69041491
112establishment of chromosome localization (GO:0051303)2.68475769
113mitotic spindle assembly checkpoint (GO:0007094)2.67890055
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67543764
115nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67423324
116glycine metabolic process (GO:0006544)2.66470645
117DNA topological change (GO:0006265)2.66357599
118regulation of mRNA stability (GO:0043488)2.66312012
119cell-substrate junction assembly (GO:0007044)2.65680212
120cell-substrate adherens junction assembly (GO:0007045)2.65266933
121focal adhesion assembly (GO:0048041)2.65266933
122establishment of RNA localization (GO:0051236)2.65070209
123histone H2B ubiquitination (GO:0033523)2.54350791
124positive regulation of cell cycle checkpoint (GO:1901978)2.49096659
125nucleobase-containing small molecule interconversion (GO:0015949)2.48860042
126cytoskeleton-dependent cytokinesis (GO:0061640)2.48852228
127regulation of glucose import in response to insulin stimulus (GO:2001273)2.47690590
128bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42248536
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42172627
130glutamine metabolic process (GO:0006541)2.39996351
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.39958336
132regulation of protein export from nucleus (GO:0046825)2.36634852
133regulation of NFAT protein import into nucleus (GO:0051532)2.35001786
134epithelial cell-cell adhesion (GO:0090136)2.34850598
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32869668
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32647365
137establishment of viral latency (GO:0019043)2.32337626
138COPII vesicle coating (GO:0048208)2.31609530
139embryonic process involved in female pregnancy (GO:0060136)2.31501806
140activation of Rac GTPase activity (GO:0032863)2.31050935
141regulation of early endosome to late endosome transport (GO:2000641)2.30628853
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30584807
143telomere maintenance via semi-conservative replication (GO:0032201)2.29887875
144establishment of apical/basal cell polarity (GO:0035089)2.29418089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.95636420
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.50911322
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.72909722
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08046159
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.67594777
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.62232037
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.35737073
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.13411108
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89460472
10AR_21909140_ChIP-Seq_LNCAP_Human2.88348361
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80080881
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54038021
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41748235
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33658785
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.30250247
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26504083
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96121324
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94914961
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92837057
20* MYC_22102868_ChIP-Seq_BL_Human1.90223075
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89267813
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82310726
23ZNF263_19887448_ChIP-Seq_K562_Human1.77317255
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72050574
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.69017874
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68775823
27XRN2_22483619_ChIP-Seq_HELA_Human1.68693072
28CLOCK_20551151_ChIP-Seq_293T_Human1.65546460
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64797505
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61818801
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60296897
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58231552
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55129520
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52029422
35* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51271922
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48729701
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48220115
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46809481
39ELK1_19687146_ChIP-ChIP_HELA_Human1.45165933
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44917142
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44710345
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43983880
43KDM5A_27292631_Chip-Seq_BREAST_Human1.43813216
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35667451
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34960744
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34510989
47SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34141183
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.33700018
49* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33503548
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32883607
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32404502
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32399082
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31361129
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31127283
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30431337
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29735934
57CHD1_26751641_Chip-Seq_LNCaP_Human1.29329195
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29305181
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27436617
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24992144
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.24807059
62* ETS1_20019798_ChIP-Seq_JURKAT_Human1.22094354
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21291978
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20210232
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19199566
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.18228580
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.17792106
68VDR_23849224_ChIP-Seq_CD4+_Human1.15907908
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15271783
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15087580
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.14427403
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14265950
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14105238
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14105238
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14105238
76TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13751436
77* TTF2_22483619_ChIP-Seq_HELA_Human1.12757050
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12546207
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11559040
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08484737
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07674380
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06890554
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06844201
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06375373
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05672150
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05600190
87ATF3_27146783_Chip-Seq_COLON_Human1.05303415
88* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04240668
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03685029
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03488979
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02261342
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01617387
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01481965
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01451564
95CIITA_25753668_ChIP-Seq_RAJI_Human1.01396796
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01092582
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99701504
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99263523
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99102915
100FOXP3_21729870_ChIP-Seq_TREG_Human0.98812306
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98544990
102DCP1A_22483619_ChIP-Seq_HELA_Human0.98416490
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98362702
104PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98247537
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96813271
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95733746
107TFEB_21752829_ChIP-Seq_HELA_Human0.95254031
108GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93688001
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93605145
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.92749359
111BRD4_25478319_ChIP-Seq_HGPS_Human0.92256444
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89604741
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88535450
114* GABP_19822575_ChIP-Seq_HepG2_Human0.88339501
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88001994
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.87359479
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87314892
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84630132
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84527362
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84035665
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83463894
122SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83426520
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83223663
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82719064
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82520927
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82460120
127GATA6_25053715_ChIP-Seq_YYC3_Human0.82245425
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82203368
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81677085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.75808695
2MP0003705_abnormal_hypodermis_morpholog3.70296412
3MP0003111_abnormal_nucleus_morphology3.37334280
4MP0003693_abnormal_embryo_hatching3.33961273
5MP0010094_abnormal_chromosome_stability3.22859431
6MP0004957_abnormal_blastocyst_morpholog3.18138098
7MP0010234_abnormal_vibrissa_follicle2.84015088
8MP0003077_abnormal_cell_cycle2.81674946
9MP0003123_paternal_imprinting2.74853835
10MP0010307_abnormal_tumor_latency2.74504472
11MP0005076_abnormal_cell_differentiation2.68435651
12MP0001730_embryonic_growth_arrest2.55171087
13MP0008057_abnormal_DNA_replication2.45467493
14MP0000537_abnormal_urethra_morphology2.39853906
15MP0004197_abnormal_fetal_growth/weight/2.19842430
16MP0000350_abnormal_cell_proliferation2.18224573
17MP0005380_embryogenesis_phenotype2.11015575
18MP0001672_abnormal_embryogenesis/_devel2.11015575
19MP0002084_abnormal_developmental_patter1.99035880
20MP0003984_embryonic_growth_retardation1.96667677
21MP0002088_abnormal_embryonic_growth/wei1.95798906
22MP0009053_abnormal_anal_canal1.94818525
23MP0002009_preneoplasia1.93265543
24MP0002086_abnormal_extraembryonic_tissu1.92290891
25MP0001697_abnormal_embryo_size1.85942687
26MP0003566_abnormal_cell_adhesion1.80668616
27MP0003890_abnormal_embryonic-extraembry1.75875683
28MP0002085_abnormal_embryonic_tissue1.75553224
29MP0003567_abnormal_fetal_cardiomyocyte1.74052209
30MP0008007_abnormal_cellular_replicative1.72243772
31MP0008932_abnormal_embryonic_tissue1.72145504
32MP0005623_abnormal_meninges_morphology1.67527323
33MP0002080_prenatal_lethality1.62570406
34MP0000733_abnormal_muscle_development1.61956690
35MP0003121_genomic_imprinting1.54201742
36MP0009697_abnormal_copulation1.54117593
37MP0000579_abnormal_nail_morphology1.52008481
38MP0003950_abnormal_plasma_membrane1.50312534
39MP0005409_darkened_coat_color1.49500896
40MP0005257_abnormal_intraocular_pressure1.46824120
41MP0009672_abnormal_birth_weight1.45185524
42MP0002877_abnormal_melanocyte_morpholog1.44652846
43MP0008058_abnormal_DNA_repair1.43968191
44MP0003937_abnormal_limbs/digits/tail_de1.42578974
45MP0000569_abnormal_digit_pigmentation1.41401977
46MP0001661_extended_life_span1.40298412
47MP0004185_abnormal_adipocyte_glucose1.35914174
48MP0000762_abnormal_tongue_morphology1.34992109
49MP0009703_decreased_birth_body1.31531410
50MP0004233_abnormal_muscle_weight1.31102087
51MP0000428_abnormal_craniofacial_morphol1.30601410
52MP0010030_abnormal_orbit_morphology1.29302473
53MP0010678_abnormal_skin_adnexa1.29268085
54MP0002060_abnormal_skin_morphology1.27344120
55MP0005451_abnormal_body_composition1.26591394
56MP0004264_abnormal_extraembryonic_tissu1.25763764
57MP0003385_abnormal_body_wall1.23962314
58MP0001293_anophthalmia1.23569578
59MP0000751_myopathy1.23389910
60MP0002396_abnormal_hematopoietic_system1.20396712
61MP0002796_impaired_skin_barrier1.19555516
62MP0003119_abnormal_digestive_system1.18948551
63MP0004084_abnormal_cardiac_muscle1.16532503
64MP0001849_ear_inflammation1.15432853
65MP0002697_abnormal_eye_size1.14914935
66MP0005023_abnormal_wound_healing1.14727120
67MP0005187_abnormal_penis_morphology1.14699561
68MP0008438_abnormal_cutaneous_collagen1.14000190
69MP0003300_gastrointestinal_ulcer1.13818415
70MP0002092_abnormal_eye_morphology1.11654532
71MP0002111_abnormal_tail_morphology1.07297250
72MP0001915_intracranial_hemorrhage1.07264543
73MP0003941_abnormal_skin_development1.05015129
74MP0000750_abnormal_muscle_regeneration1.02605929
75MP0000759_abnormal_skeletal_muscle1.00704024
76MP0003091_abnormal_cell_migration0.99382912
77MP0004808_abnormal_hematopoietic_stem0.98829151
78MP0005501_abnormal_skin_physiology0.97821506
79MP0003942_abnormal_urinary_system0.93823010
80MP0003935_abnormal_craniofacial_develop0.93348027
81MP0006054_spinal_hemorrhage0.92695891
82MP0001348_abnormal_lacrimal_gland0.92566042
83MP0003315_abnormal_perineum_morphology0.92540079
84MP0003221_abnormal_cardiomyocyte_apopto0.91089365
85MP0003115_abnormal_respiratory_system0.90808541
86MP0002925_abnormal_cardiovascular_devel0.89372185
87MP0000383_abnormal_hair_follicle0.89353957
88MP0000432_abnormal_head_morphology0.89101791
89MP0006138_congestive_heart_failure0.89005876
90MP0000534_abnormal_ureter_morphology0.87804730
91MP0008770_decreased_survivor_rate0.87280492
92MP0003806_abnormal_nucleotide_metabolis0.86929546
93MP0003786_premature_aging0.85995726
94MP0000003_abnormal_adipose_tissue0.85867993
95MP0010630_abnormal_cardiac_muscle0.84958619
96MP0004272_abnormal_basement_membrane0.83635000
97MP0002269_muscular_atrophy0.83548072
98MP0001299_abnormal_eye_distance/0.82982667
99MP0002896_abnormal_bone_mineralization0.82611408
100MP0000749_muscle_degeneration0.82470062
101MP0005621_abnormal_cell_physiology0.82159245
102MP0005666_abnormal_adipose_tissue0.81141250
103MP0000313_abnormal_cell_death0.80912372
104MP0002019_abnormal_tumor_incidence0.80507745
105MP0005275_abnormal_skin_tensile0.80364251
106MP0008877_abnormal_DNA_methylation0.79687781
107MP0000747_muscle_weakness0.79639608
108MP0009780_abnormal_chondrocyte_physiolo0.79248703
109MP0005384_cellular_phenotype0.78694356
110MP0001286_abnormal_eye_development0.78599144
111MP0003755_abnormal_palate_morphology0.78058780
112MP0000627_abnormal_mammary_gland0.77738913
113MP0005248_abnormal_Harderian_gland0.76938144
114MP0000467_abnormal_esophagus_morphology0.75872698
115MP0000266_abnormal_heart_morphology0.73783562
116MP0003718_maternal_effect0.73659420
117MP0004087_abnormal_muscle_fiber0.70936971
118MP0000377_abnormal_hair_follicle0.69915639
119MP0003453_abnormal_keratinocyte_physiol0.69221190
120MP0003861_abnormal_nervous_system0.69073072
121MP0000358_abnormal_cell_content/0.66672300
122MP0000490_abnormal_crypts_of0.66542792
123MP0000516_abnormal_urinary_system0.62056242
124MP0005367_renal/urinary_system_phenotyp0.62056242
125MP0003283_abnormal_digestive_organ0.60690022

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.68473040
2Abnormality of the astrocytes (HP:0100707)3.13154565
3Astrocytoma (HP:0009592)3.13154565
4Pelvic girdle muscle weakness (HP:0003749)3.02071772
5Abnormality of the labia minora (HP:0012880)3.01493344
6Biliary tract neoplasm (HP:0100574)2.91635293
7Asymmetry of the thorax (HP:0001555)2.86358911
8Colon cancer (HP:0003003)2.78796924
9Shoulder girdle muscle weakness (HP:0003547)2.75564494
10Selective tooth agenesis (HP:0001592)2.71429010
11Hyperacusis (HP:0010780)2.70076818
12Deviation of the thumb (HP:0009603)2.68837083
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62703674
14Subacute progressive viral hepatitis (HP:0006572)2.59771759
15Proximal placement of thumb (HP:0009623)2.53661416
16Glioma (HP:0009733)2.53627402
17Abnormality of the musculature of the pelvis (HP:0001469)2.53595269
18Abnormality of the hip-girdle musculature (HP:0001445)2.53595269
19Volvulus (HP:0002580)2.51148460
20Medulloblastoma (HP:0002885)2.48153855
21Insomnia (HP:0100785)2.42236093
22Spastic diplegia (HP:0001264)2.36713239
23Rhabdomyosarcoma (HP:0002859)2.34251751
24Abnormality of the calcaneus (HP:0008364)2.33070804
25Gastrointestinal carcinoma (HP:0002672)2.32867843
26Malignant gastrointestinal tract tumors (HP:0006749)2.32867843
27Pseudobulbar signs (HP:0002200)2.31737206
28Shallow orbits (HP:0000586)2.30729482
29Short 4th metacarpal (HP:0010044)2.26994597
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26994597
31Increased density of long bones (HP:0006392)2.26925199
32Ankle contracture (HP:0006466)2.26310318
33Impulsivity (HP:0100710)2.26129352
34Syringomyelia (HP:0003396)2.23857849
35Spinal cord lesions (HP:0100561)2.23857849
36Deep philtrum (HP:0002002)2.21856144
37Right ventricular cardiomyopathy (HP:0011663)2.18247091
38Increased nuchal translucency (HP:0010880)2.16205390
39Sandal gap (HP:0001852)2.14177107
40Increased connective tissue (HP:0009025)2.13194134
41Premature rupture of membranes (HP:0001788)2.13166452
42Hypopigmentation of the fundus (HP:0007894)2.10064598
43Distal lower limb amyotrophy (HP:0008944)2.09609210
44Neoplasm of the oral cavity (HP:0100649)2.09517508
45Missing ribs (HP:0000921)2.09499147
46Dysmetric saccades (HP:0000641)2.08567834
47Abnormality of the left ventricular outflow tract (HP:0011103)2.05924332
48Subaortic stenosis (HP:0001682)2.05924332
49Heterotopia (HP:0002282)2.04834012
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03236904
51Renal duplication (HP:0000075)2.02950797
52Relative macrocephaly (HP:0004482)2.02116767
53Abnormality of the lower motor neuron (HP:0002366)2.00102317
54Nemaline bodies (HP:0003798)2.00038471
55Nephroblastoma (Wilms tumor) (HP:0002667)1.99277974
56Lower limb amyotrophy (HP:0007210)1.98970241
57Overlapping toe (HP:0001845)1.98606706
58Difficulty climbing stairs (HP:0003551)1.98401364
59Short humerus (HP:0005792)1.96783808
60Rectal prolapse (HP:0002035)1.95643781
61Birth length less than 3rd percentile (HP:0003561)1.95041999
62Hypoplastic ischia (HP:0003175)1.94999776
63Muscle fiber inclusion bodies (HP:0100299)1.94666912
64Arterial tortuosity (HP:0005116)1.92669339
65Progressive muscle weakness (HP:0003323)1.92605184
66Resting tremor (HP:0002322)1.92559257
67Facial hemangioma (HP:0000329)1.92503484
68Aplasia/hypoplasia of the humerus (HP:0006507)1.92438710
69Embryonal renal neoplasm (HP:0011794)1.90925300
70Prominent nose (HP:0000448)1.89935461
71Cutaneous melanoma (HP:0012056)1.89783730
72Wrist flexion contracture (HP:0001239)1.89565740
73Abnormality of the 4th metacarpal (HP:0010012)1.88298730
74Abnormality of chromosome stability (HP:0003220)1.87779427
75Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87461146
76Ankyloglossia (HP:0010296)1.86522801
77Overriding aorta (HP:0002623)1.86414234
78Limb-girdle muscle weakness (HP:0003325)1.85942883
79Spinal rigidity (HP:0003306)1.85902579
80Vertebral arch anomaly (HP:0008438)1.85524986
81Uterine neoplasm (HP:0010784)1.85221262
82Elfin facies (HP:0004428)1.84247445
83Calcaneovalgus deformity (HP:0001848)1.83839653
84Progressive external ophthalmoplegia (HP:0000590)1.83157871
85Neoplasm of striated muscle (HP:0009728)1.83136461
86Flat acetabular roof (HP:0003180)1.82899059
87Skull defect (HP:0001362)1.82164654
88Esophageal atresia (HP:0002032)1.82150141
89Broad thumb (HP:0011304)1.81443990
90Type 1 muscle fiber predominance (HP:0003803)1.80774834
91Fibrous tissue neoplasm (HP:0012316)1.80658985
92Absent radius (HP:0003974)1.80611085
93High pitched voice (HP:0001620)1.80379269
94Enlarged penis (HP:0000040)1.80054591
95Ulnar bowing (HP:0003031)1.80037631
96Protrusio acetabuli (HP:0003179)1.79852669
97Cortical dysplasia (HP:0002539)1.79318731
98Abnormal biliary tract morphology (HP:0012440)1.78983454
99Cerebral aneurysm (HP:0004944)1.78652162
100Multiple enchondromatosis (HP:0005701)1.78497837
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.78341506
102Cafe-au-lait spot (HP:0000957)1.77910544
103Papillary thyroid carcinoma (HP:0002895)1.77695549
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.77340610
105Microglossia (HP:0000171)1.76953557
106Advanced eruption of teeth (HP:0006288)1.76324438
107Fibroma (HP:0010614)1.76276997
108Insidious onset (HP:0003587)1.75729308
109Termporal pattern (HP:0011008)1.75729308
110Arnold-Chiari malformation (HP:0002308)1.75646122
111Disproportionate tall stature (HP:0001519)1.75193145
112Leiomyosarcoma (HP:0100243)1.74918416
113Uterine leiomyosarcoma (HP:0002891)1.74918416
114Exercise-induced muscle cramps (HP:0003710)1.74744387
115Angiofibromas (HP:0010615)1.74733079
116Adenoma sebaceum (HP:0009720)1.74733079
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74679268
118Osteolytic defects of the hand bones (HP:0009699)1.74639490
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.74639490
120Pterygium (HP:0001059)1.74451841
121Chromsome breakage (HP:0040012)1.74434053
122Bowel diverticulosis (HP:0005222)1.74039551
123Atrophic scars (HP:0001075)1.71926966
124Basal cell carcinoma (HP:0002671)1.71019252
125Fragile skin (HP:0001030)1.69895496
126Vascular tortuosity (HP:0004948)1.69801949
127Back pain (HP:0003418)1.69731095
128Atresia of the external auditory canal (HP:0000413)1.68322917
129Urethral obstruction (HP:0000796)1.68260794
130Abnormality of oral frenula (HP:0000190)1.68080133
131Short nail (HP:0001799)1.67191699
132Trismus (HP:0000211)1.67174956
133Breech presentation (HP:0001623)1.66740195
134Intestinal polyposis (HP:0200008)1.65308331
135Absent forearm bone (HP:0003953)1.64968444
136Aplasia involving forearm bones (HP:0009822)1.64968444
137Metaphyseal cupping (HP:0003021)1.64124703
138Natal tooth (HP:0000695)1.64097657
139Neoplasm of the pancreas (HP:0002894)1.63574734
140Vertebral clefting (HP:0008428)1.63288784
141Genu recurvatum (HP:0002816)1.63008886
142Abnormality of the ischium (HP:0003174)1.62988881
143Ovarian neoplasm (HP:0100615)1.62790175
144Mitral valve prolapse (HP:0001634)1.62311186
145Mildly elevated creatine phosphokinase (HP:0008180)1.61576563
146Intestinal polyp (HP:0005266)1.61116762
147Cubitus valgus (HP:0002967)1.60942396
148Agnosia (HP:0010524)1.60702986
149Bladder diverticulum (HP:0000015)1.60107188
150Achilles tendon contracture (HP:0001771)1.59891690
151Abnormality of the Achilles tendon (HP:0005109)1.59558246
152Radial bowing (HP:0002986)1.58290910
153Neoplasm of the small intestine (HP:0100833)1.57990031
154Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57846470
155Renovascular hypertension (HP:0100817)1.57771273
156Wormian bones (HP:0002645)1.57332423
157Coronal craniosynostosis (HP:0004440)1.55340157
158Abnormality of the salivary glands (HP:0010286)1.54934591
159Hammertoe (HP:0001765)1.53392845
160Abnormality of pain sensation (HP:0010832)1.53189146
161Impaired pain sensation (HP:0007328)1.53189146
162High anterior hairline (HP:0009890)1.52515221
163Deformed tarsal bones (HP:0008119)1.50722390
164Metatarsus adductus (HP:0001840)1.49258622
165Transitional cell carcinoma of the bladder (HP:0006740)1.49196624
166Limited elbow extension (HP:0001377)1.48759628
167Broad face (HP:0000283)1.48149909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.54146633
2PKN23.28885524
3CDK123.24540583
4EEF2K2.99174085
5NEK12.87512425
6EPHA22.74595847
7WEE12.65891203
8LATS12.56900729
9MST1R2.40488003
10NEK22.32179784
11TTN2.27246398
12ICK2.24799746
13SCYL22.22519870
14TSSK62.20020679
15PBK2.19923718
16TTK2.10290667
17RPS6KB22.02042964
18SMG11.93532967
19ALK1.89160176
20SRPK11.85917340
21TRIB31.81309564
22PLK31.62632710
23BUB11.58393673
24CDK61.55242378
25STK31.54671764
26PNCK1.51433009
27MAP3K81.46658176
28PASK1.45858894
29BRD41.41210010
30IRAK31.40714617
31MKNK11.40168126
32CDK41.39454156
33AURKB1.35915012
34CHEK11.32325411
35PLK11.31704867
36LATS21.30200070
37MAP3K101.25357119
38EIF2AK11.23539728
39FGFR11.21906178
40MTOR1.20762097
41STK101.20524187
42FRK1.20382545
43BRSK21.18969381
44MAP3K91.18175210
45TAF11.18074742
46ATR1.17421579
47PAK21.15699644
48PLK41.15292550
49PDGFRA1.14126594
50PTK61.13422015
51NTRK11.11069155
52ZAK1.09985856
53TLK11.07398243
54CHEK21.07067383
55FGFR41.04895955
56MKNK21.02978872
57ATM1.01375407
58RIPK10.97450674
59CDK70.95413382
60PAK40.92026626
61DDR20.90678673
62RPS6KA40.90345890
63KSR20.90130135
64LRRK20.89535115
65CDK20.89528153
66ACVR1B0.89280562
67DMPK0.88373737
68TGFBR10.87013275
69PDK40.80250863
70PDK30.80250863
71CSNK1E0.79569742
72MELK0.79098575
73CSNK1D0.76639913
74PRPF4B0.75941787
75FLT30.75842315
76BRAF0.75310914
77BMX0.73431965
78STK40.73213872
79STK240.73139553
80CAMK1D0.72938013
81CDK10.70916607
82NME20.66713951
83MET0.65986930
84FGFR20.64914625
85PRKDC0.62420040
86AKT20.62144139
87EIF2AK20.61196902
88ERBB30.60226986
89CLK10.59596311
90AKT30.59437583
91EIF2AK30.59168733
92CDK80.58911632
93MOS0.57421782
94AURKA0.57417415
95STK38L0.56289537
96PDGFRB0.53568401
97DYRK30.52783293
98NEK90.52338692
99KSR10.50991979
100ERBB40.50926523
101FER0.50839250
102PDK20.50358319
103CSNK2A20.50106328
104MAP3K20.48074346
105WNK10.47585945
106PIM10.47546383
107OBSCN0.46274254
108PRKCI0.44259205
109LMTK20.43633132
110MAPK140.43070009
111NEK60.42771180
112BRSK10.39723840
113YES10.39408887
114PTK20.38728612
115RAF10.37263809
116CAMK1G0.36989350
117FGFR30.36611836
118TYRO30.36572594
119CDK150.36322579
120CDK90.34723571
121RET0.34705223
122TRPM70.34159300
123RPS6KB10.33686788
124MAPK100.32935949
125SIK10.31571136
126PAK10.31137147
127GSK3B0.30470258
128AKT10.28625802
129GSK3A0.28047817

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63296271
2One carbon pool by folate_Homo sapiens_hsa006703.45620483
3RNA transport_Homo sapiens_hsa030133.42537023
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03672509
5DNA replication_Homo sapiens_hsa030302.64911311
6Cell cycle_Homo sapiens_hsa041102.64731739
7Spliceosome_Homo sapiens_hsa030402.53644441
8Mismatch repair_Homo sapiens_hsa034302.51380244
9Systemic lupus erythematosus_Homo sapiens_hsa053222.48634434
10mRNA surveillance pathway_Homo sapiens_hsa030152.20564796
11Nucleotide excision repair_Homo sapiens_hsa034201.79909943
12MicroRNAs in cancer_Homo sapiens_hsa052061.68661731
13Viral carcinogenesis_Homo sapiens_hsa052031.66668732
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61055536
15p53 signaling pathway_Homo sapiens_hsa041151.56553779
16mTOR signaling pathway_Homo sapiens_hsa041501.55604003
17Biosynthesis of amino acids_Homo sapiens_hsa012301.54873978
18Selenocompound metabolism_Homo sapiens_hsa004501.44751838
19Small cell lung cancer_Homo sapiens_hsa052221.44242059
20RNA degradation_Homo sapiens_hsa030181.44204243
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43076684
22Adherens junction_Homo sapiens_hsa045201.38993414
23Nitrogen metabolism_Homo sapiens_hsa009101.35605268
24Fanconi anemia pathway_Homo sapiens_hsa034601.33252832
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32317004
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32291270
27Hippo signaling pathway_Homo sapiens_hsa043901.31898761
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.29931669
29Lysine degradation_Homo sapiens_hsa003101.27780263
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24629617
31Oocyte meiosis_Homo sapiens_hsa041141.20136756
32Non-homologous end-joining_Homo sapiens_hsa034501.19418860
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18196061
34Proteoglycans in cancer_Homo sapiens_hsa052051.16195634
35RNA polymerase_Homo sapiens_hsa030201.15657435
36Chronic myeloid leukemia_Homo sapiens_hsa052201.15432002
37Base excision repair_Homo sapiens_hsa034101.10667783
38Homologous recombination_Homo sapiens_hsa034401.08050995
39Vitamin B6 metabolism_Homo sapiens_hsa007501.06509456
40ErbB signaling pathway_Homo sapiens_hsa040121.01483003
41Alcoholism_Homo sapiens_hsa050341.01308704
42Pyruvate metabolism_Homo sapiens_hsa006201.00840054
43TGF-beta signaling pathway_Homo sapiens_hsa043500.99795918
44Tight junction_Homo sapiens_hsa045300.99091081
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.98637293
46Bladder cancer_Homo sapiens_hsa052190.98404308
47Carbon metabolism_Homo sapiens_hsa012000.97551111
48HTLV-I infection_Homo sapiens_hsa051660.96470900
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95108705
50Focal adhesion_Homo sapiens_hsa045100.94665735
51Colorectal cancer_Homo sapiens_hsa052100.92618226
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90566478
53Thyroid cancer_Homo sapiens_hsa052160.89954071
54Basal cell carcinoma_Homo sapiens_hsa052170.86757222
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85965961
56Dilated cardiomyopathy_Homo sapiens_hsa054140.85667215
57Epstein-Barr virus infection_Homo sapiens_hsa051690.85550500
58ECM-receptor interaction_Homo sapiens_hsa045120.84536400
59Endometrial cancer_Homo sapiens_hsa052130.84352681
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83866376
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83342544
62Fatty acid biosynthesis_Homo sapiens_hsa000610.81479138
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80550789
64Pyrimidine metabolism_Homo sapiens_hsa002400.80022538
65Prion diseases_Homo sapiens_hsa050200.79513375
66Prostate cancer_Homo sapiens_hsa052150.78598411
67HIF-1 signaling pathway_Homo sapiens_hsa040660.78401340
68Antigen processing and presentation_Homo sapiens_hsa046120.78306480
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76410898
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.74045215
71Viral myocarditis_Homo sapiens_hsa054160.72175079
72Non-small cell lung cancer_Homo sapiens_hsa052230.72164390
73Arginine biosynthesis_Homo sapiens_hsa002200.69275533
74Pentose phosphate pathway_Homo sapiens_hsa000300.68896114
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68697130
76Renal cell carcinoma_Homo sapiens_hsa052110.68557598
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68156127
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66450753
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65499497
80VEGF signaling pathway_Homo sapiens_hsa043700.62673516
81Steroid biosynthesis_Homo sapiens_hsa001000.62355354
82Basal transcription factors_Homo sapiens_hsa030220.61924859
83AMPK signaling pathway_Homo sapiens_hsa041520.61248783
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59789046
85FoxO signaling pathway_Homo sapiens_hsa040680.58136573
86Amoebiasis_Homo sapiens_hsa051460.57978463
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57929314
88Acute myeloid leukemia_Homo sapiens_hsa052210.57810677
89Glioma_Homo sapiens_hsa052140.57079645
90N-Glycan biosynthesis_Homo sapiens_hsa005100.55931184
91Melanogenesis_Homo sapiens_hsa049160.55754541
92Thyroid hormone synthesis_Homo sapiens_hsa049180.53128746
93Pathways in cancer_Homo sapiens_hsa052000.53023951
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.52842691
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.52283157
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52170788
97Inositol phosphate metabolism_Homo sapiens_hsa005620.51962180
98Melanoma_Homo sapiens_hsa052180.51316946
99Long-term potentiation_Homo sapiens_hsa047200.48295021
100Glucagon signaling pathway_Homo sapiens_hsa049220.48121863
101Insulin signaling pathway_Homo sapiens_hsa049100.47898430
102Galactose metabolism_Homo sapiens_hsa000520.47384065
103Ribosome_Homo sapiens_hsa030100.47184092
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47007990
105Pancreatic cancer_Homo sapiens_hsa052120.46846929
106Gap junction_Homo sapiens_hsa045400.46299302
107Prolactin signaling pathway_Homo sapiens_hsa049170.45979969
108Insulin resistance_Homo sapiens_hsa049310.45563054
109Fructose and mannose metabolism_Homo sapiens_hsa000510.45510786
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43359873
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43243949
112Hedgehog signaling pathway_Homo sapiens_hsa043400.42770708
113Wnt signaling pathway_Homo sapiens_hsa043100.42747269
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42024953
115Estrogen signaling pathway_Homo sapiens_hsa049150.39448839
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39184876
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38984348
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35616660
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.35080192
120Notch signaling pathway_Homo sapiens_hsa043300.34902350
121Herpes simplex infection_Homo sapiens_hsa051680.34407524
122Hepatitis B_Homo sapiens_hsa051610.33502404
123Dorso-ventral axis formation_Homo sapiens_hsa043200.33458520

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