IPO11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP metabolic process (GO:0046040)5.04348203
2DNA unwinding involved in DNA replication (GO:0006268)4.93229001
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.83424404
4tRNA methylation (GO:0030488)4.79970170
5protein localization to kinetochore (GO:0034501)4.60545793
6IMP biosynthetic process (GO:0006188)4.56488591
7DNA replication initiation (GO:0006270)4.43506946
8establishment of integrated proviral latency (GO:0075713)4.37845724
9nuclear pore organization (GO:0006999)4.28292760
10nuclear pore complex assembly (GO:0051292)4.20089942
11nucleobase biosynthetic process (GO:0046112)4.18622543
12non-recombinational repair (GO:0000726)4.08951378
13double-strand break repair via nonhomologous end joining (GO:0006303)4.08951378
14DNA strand elongation involved in DNA replication (GO:0006271)4.05755021
15ribosomal small subunit assembly (GO:0000028)4.03511491
16peptidyl-arginine omega-N-methylation (GO:0035247)4.02679619
17formation of translation preinitiation complex (GO:0001731)3.99562751
18purine nucleobase biosynthetic process (GO:0009113)3.94115589
19mitotic nuclear envelope disassembly (GO:0007077)3.87218072
20definitive hemopoiesis (GO:0060216)3.87100397
21DNA strand elongation (GO:0022616)3.86188571
22DNA ligation (GO:0006266)3.85059151
23mitotic metaphase plate congression (GO:0007080)3.78443246
24telomere maintenance via semi-conservative replication (GO:0032201)3.76084220
25protein localization to chromosome, centromeric region (GO:0071459)3.71064455
26CENP-A containing nucleosome assembly (GO:0034080)3.69729185
27nuclear envelope disassembly (GO:0051081)3.67558578
28membrane disassembly (GO:0030397)3.67558578
29ribosome biogenesis (GO:0042254)3.67406484
30DNA replication-dependent nucleosome organization (GO:0034723)3.63282750
31DNA replication-dependent nucleosome assembly (GO:0006335)3.63282750
32maturation of SSU-rRNA (GO:0030490)3.62634287
33histone-serine phosphorylation (GO:0035404)3.62510519
34meiotic chromosome segregation (GO:0045132)3.62249019
35chromatin remodeling at centromere (GO:0031055)3.60881827
36telomere maintenance via recombination (GO:0000722)3.58804042
37metaphase plate congression (GO:0051310)3.58002129
38kinetochore organization (GO:0051383)3.56922691
39mitotic recombination (GO:0006312)3.56753483
40regulation of histone H3-K9 methylation (GO:0051570)3.55891335
41negative regulation of chromosome segregation (GO:0051985)3.55361695
42replication fork processing (GO:0031297)3.54727777
43chromosome condensation (GO:0030261)3.54028061
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.53936934
45negative regulation of sister chromatid segregation (GO:0033046)3.53936934
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.53936934
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.53936934
48mitotic sister chromatid segregation (GO:0000070)3.51367622
49sister chromatid segregation (GO:0000819)3.50943007
50DNA replication-independent nucleosome assembly (GO:0006336)3.48173542
51DNA replication-independent nucleosome organization (GO:0034724)3.48173542
52peptidyl-arginine N-methylation (GO:0035246)3.47426306
53peptidyl-arginine methylation (GO:0018216)3.47426306
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.46568788
55mitotic sister chromatid cohesion (GO:0007064)3.45630504
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.45583929
57translesion synthesis (GO:0019985)3.45315282
58pre-miRNA processing (GO:0031054)3.44161025
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.41139394
60spindle assembly checkpoint (GO:0071173)3.40177785
61mitotic chromosome condensation (GO:0007076)3.39653725
62DNA duplex unwinding (GO:0032508)3.39559008
63histone arginine methylation (GO:0034969)3.39334561
64DNA geometric change (GO:0032392)3.38657792
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36847238
66attachment of spindle microtubules to kinetochore (GO:0008608)3.35990614
67mitotic spindle assembly checkpoint (GO:0007094)3.34381993
68chromosome segregation (GO:0007059)3.32957350
69regulation of spindle organization (GO:0090224)3.32890873
70regulation of sister chromatid segregation (GO:0033045)3.30855377
71regulation of mitotic sister chromatid separation (GO:0010965)3.30855377
72regulation of mitotic sister chromatid segregation (GO:0033047)3.30855377
73DNA topological change (GO:0006265)3.29952271
74positive regulation of chromosome segregation (GO:0051984)3.29266449
75spindle checkpoint (GO:0031577)3.28523306
76regulation of chromosome segregation (GO:0051983)3.27770809
77DNA strand renaturation (GO:0000733)3.27417371
78negative regulation of histone methylation (GO:0031061)3.27207454
79establishment of viral latency (GO:0019043)3.26355140
80microtubule depolymerization (GO:0007019)3.26316182
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.26192848
82mitotic G2/M transition checkpoint (GO:0044818)3.25084640
83DNA packaging (GO:0006323)3.23755552
84regulation of mitotic spindle organization (GO:0060236)3.23342746
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.23132433
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23132433
87N-terminal protein amino acid acetylation (GO:0006474)3.23122814
88regulation of sister chromatid cohesion (GO:0007063)3.22771459
89regulation of DNA endoreduplication (GO:0032875)3.21966612
90spliceosomal snRNP assembly (GO:0000387)3.18076050
91histone exchange (GO:0043486)3.17929089
92mitotic spindle checkpoint (GO:0071174)3.17321478
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17163945
94negative regulation of DNA recombination (GO:0045910)3.14850332
95ribonucleoprotein complex biogenesis (GO:0022613)3.13343129
96protein complex localization (GO:0031503)3.12325110
97regulation of translational fidelity (GO:0006450)3.11731084
98protein localization to chromosome (GO:0034502)3.10488528
99establishment of chromosome localization (GO:0051303)3.10317893
100pore complex assembly (GO:0046931)3.08511518
101telomere maintenance via telomere lengthening (GO:0010833)3.08439785
102regulation of centrosome cycle (GO:0046605)3.07836304
103regulation of centriole replication (GO:0046599)3.07422769
104epithelial cell differentiation involved in prostate gland development (GO:0060742)3.07281160
105regulation of translation in response to stress (GO:0043555)3.06890205
106regulation of centrosome duplication (GO:0010824)3.05964553
107postreplication repair (GO:0006301)3.04686949
108DNA double-strand break processing (GO:0000729)3.03821585
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02705759
110folic acid-containing compound biosynthetic process (GO:0009396)3.01711806
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.00546866
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00546866
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00546866
114synapsis (GO:0007129)3.00513200
115ribosome assembly (GO:0042255)3.00203488
116kinetochore assembly (GO:0051382)2.98759934
117tRNA aminoacylation for protein translation (GO:0006418)2.98520010
118ATP-dependent chromatin remodeling (GO:0043044)2.98378829
119negative regulation of DNA repair (GO:0045738)2.97828565
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.95067456
121DNA conformation change (GO:0071103)2.94261719
122regulation of DNA methylation (GO:0044030)2.92719370
123chromatin assembly or disassembly (GO:0006333)2.91065814
124DNA replication checkpoint (GO:0000076)2.90598689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50104676
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.47527358
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.45350746
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37131229
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27362876
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02783026
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93610137
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71888424
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61521844
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54464681
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.53702923
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51310449
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32490208
14AR_21909140_ChIP-Seq_LNCAP_Human2.27552291
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22279396
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.21306542
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.19184553
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17611845
19XRN2_22483619_ChIP-Seq_HELA_Human2.13064998
20VDR_23849224_ChIP-Seq_CD4+_Human2.12738743
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.10822888
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10233018
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10059772
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04706131
25E2F7_22180533_ChIP-Seq_HELA_Human10.1251590
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99235705
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93812911
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93504529
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89929003
30* ELK1_19687146_ChIP-ChIP_HELA_Human1.88494937
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87844963
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.87003726
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82344253
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80397712
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79943317
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77318349
37SCL_19346495_ChIP-Seq_HPC-7_Human1.74696505
38FOXP3_21729870_ChIP-Seq_TREG_Human1.73339108
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72814219
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72522777
41* TTF2_22483619_ChIP-Seq_HELA_Human1.69693749
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.67013538
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65020765
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64985921
45* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61858452
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60868058
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60463876
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60373706
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57619316
50CIITA_25753668_ChIP-Seq_RAJI_Human1.55355512
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55155804
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53139804
53MYC_22102868_ChIP-Seq_BL_Human1.52395027
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.52166160
55GABP_19822575_ChIP-Seq_HepG2_Human1.51607902
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50621673
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45574943
58GATA1_22025678_ChIP-Seq_K562_Human1.38175943
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34557819
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33798591
61* KDM5A_27292631_Chip-Seq_BREAST_Human1.32561853
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30078914
63* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29462083
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27672295
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27582647
66DCP1A_22483619_ChIP-Seq_HELA_Human1.27513984
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26121431
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23851999
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21222557
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19293254
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17072045
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17021111
73FUS_26573619_Chip-Seq_HEK293_Human1.15806082
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13138654
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12415610
76ZNF263_19887448_ChIP-Seq_K562_Human1.11637598
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11285697
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10835526
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10059385
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.08643638
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08293505
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05643837
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05424640
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05424640
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05424640
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02297765
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.99312496
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98594302
89* SRF_21415370_ChIP-Seq_HL-1_Mouse0.96991480
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96049071
91MYC_18940864_ChIP-ChIP_HL60_Human0.94832280
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94086166
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93881671
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.93182014
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92968821
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92758354
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92672532
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92102503
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91954120
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90805979
101EWS_26573619_Chip-Seq_HEK293_Human0.90688146
102* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90581933
103IGF1R_20145208_ChIP-Seq_DFB_Human0.89465348
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88896773
105IRF1_19129219_ChIP-ChIP_H3396_Human0.87231703
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.85867631
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85483346
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84781916
109* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84349482
110TFEB_21752829_ChIP-Seq_HELA_Human0.84007992
111SPI1_23547873_ChIP-Seq_NB4_Human0.83577265
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.82321407
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.81539235
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81406381
115VDR_22108803_ChIP-Seq_LS180_Human0.81061191
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.79386311
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78354025
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75227674
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75144742
120CHD1_26751641_Chip-Seq_LNCaP_Human0.73686093
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72894666
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72143146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.73510943
2MP0003123_paternal_imprinting4.31163608
3MP0010094_abnormal_chromosome_stability3.88833232
4MP0003693_abnormal_embryo_hatching3.52435311
5MP0009697_abnormal_copulation3.46906153
6MP0004957_abnormal_blastocyst_morpholog3.37929980
7MP0004510_myositis3.34762307
8MP0000569_abnormal_digit_pigmentation3.13844056
9MP0003111_abnormal_nucleus_morphology3.08890418
10MP0003077_abnormal_cell_cycle3.05880987
11MP0004808_abnormal_hematopoietic_stem2.92185959
12MP0002396_abnormal_hematopoietic_system2.82416548
13MP0008057_abnormal_DNA_replication2.74285154
14MP0008058_abnormal_DNA_repair2.51733518
15MP0003121_genomic_imprinting2.48494415
16MP0008007_abnormal_cellular_replicative2.48199952
17MP0003890_abnormal_embryonic-extraembry2.43807396
18MP0003941_abnormal_skin_development2.42873456
19MP0001293_anophthalmia2.06390586
20MP0001730_embryonic_growth_arrest2.04440493
21MP0008877_abnormal_DNA_methylation2.01753551
22MP0003567_abnormal_fetal_cardiomyocyte1.92056305
23MP0008932_abnormal_embryonic_tissue1.89770272
24MP0002009_preneoplasia1.86775399
25MP0010307_abnormal_tumor_latency1.84533042
26MP0001697_abnormal_embryo_size1.81380770
27MP0000350_abnormal_cell_proliferation1.76767982
28MP0006054_spinal_hemorrhage1.76221003
29MP0010352_gastrointestinal_tract_polyps1.70944274
30MP0005380_embryogenesis_phenotype1.69987699
31MP0001672_abnormal_embryogenesis/_devel1.69987699
32MP0002086_abnormal_extraembryonic_tissu1.64682285
33MP0010368_abnormal_lymphatic_system1.57813744
34MP0003279_aneurysm1.57185924
35MP0005397_hematopoietic_system_phenotyp1.52932534
36MP0001545_abnormal_hematopoietic_system1.52932534
37MP0003984_embryonic_growth_retardation1.52289839
38MP0002088_abnormal_embryonic_growth/wei1.50024010
39MP0002080_prenatal_lethality1.46788310
40MP0002084_abnormal_developmental_patter1.44564746
41MP0004272_abnormal_basement_membrane1.43652598
42MP0001661_extended_life_span1.43589005
43MP0003718_maternal_effect1.39577716
44MP0000358_abnormal_cell_content/1.37187923
45MP0004147_increased_porphyrin_level1.35501511
46MP0005174_abnormal_tail_pigmentation1.35376107
47MP0005075_abnormal_melanosome_morpholog1.33100573
48MP0002095_abnormal_skin_pigmentation1.31096269
49MP0004197_abnormal_fetal_growth/weight/1.27207889
50MP0002085_abnormal_embryonic_tissue1.26245594
51MP0006035_abnormal_mitochondrial_morpho1.24156841
52MP0000749_muscle_degeneration1.20401951
53MP0004233_abnormal_muscle_weight1.18240733
54MP0003786_premature_aging1.18029346
55MP0001879_abnormal_lymphatic_vessel1.17922931
56MP0003943_abnormal_hepatobiliary_system1.17254457
57MP0002697_abnormal_eye_size1.14760864
58MP0000313_abnormal_cell_death1.13666374
59MP0009278_abnormal_bone_marrow1.13495921
60MP0005083_abnormal_biliary_tract1.09476976
61MP0002019_abnormal_tumor_incidence1.07927121
62MP0002210_abnormal_sex_determination1.06527897
63MP0002938_white_spotting1.06466408
64MP0000490_abnormal_crypts_of1.04411109
65MP0000428_abnormal_craniofacial_morphol1.04076570
66MP0003950_abnormal_plasma_membrane1.02975577
67MP0000703_abnormal_thymus_morphology1.00332454
68MP0001919_abnormal_reproductive_system0.99052742
69MP0001915_intracranial_hemorrhage0.98695456
70MP0005389_reproductive_system_phenotype0.98681891
71MP0005501_abnormal_skin_physiology0.96190062
72MP0000015_abnormal_ear_pigmentation0.96067026
73MP0003566_abnormal_cell_adhesion0.95927340
74MP0001145_abnormal_male_reproductive0.95594332
75MP0002398_abnormal_bone_marrow0.95465956
76MP0003385_abnormal_body_wall0.93766802
77MP0004084_abnormal_cardiac_muscle0.90847008
78MP0000465_gastrointestinal_hemorrhage0.88856471
79MP0002166_altered_tumor_susceptibility0.87055901
80MP0006072_abnormal_retinal_apoptosis0.85472512
81MP0003119_abnormal_digestive_system0.84538256
82MP0004215_abnormal_myocardial_fiber0.83462945
83MP0005623_abnormal_meninges_morphology0.82950006
84MP0002722_abnormal_immune_system0.82903290
85MP0009053_abnormal_anal_canal0.82135974
86MP0000689_abnormal_spleen_morphology0.81151988
87MP0002092_abnormal_eye_morphology0.80246789
88MP0005384_cellular_phenotype0.79859216
89MP0003698_abnormal_male_reproductive0.78230504
90MP0000653_abnormal_sex_gland0.76369929
91MP0002075_abnormal_coat/hair_pigmentati0.75587346
92MP0003122_maternal_imprinting0.75260331
93MP0005167_abnormal_blood-brain_barrier0.74888419
94MP0003221_abnormal_cardiomyocyte_apopto0.73918816
95MP0000537_abnormal_urethra_morphology0.73838560
96MP0003315_abnormal_perineum_morphology0.71823348
97MP0002233_abnormal_nose_morphology0.71793624
98MP0002925_abnormal_cardiovascular_devel0.70629176
99MP0002006_tumorigenesis0.70009014
100MP0001119_abnormal_female_reproductive0.69789056
101MP0002160_abnormal_reproductive_system0.69194312
102MP0003935_abnormal_craniofacial_develop0.69154152
103MP0006036_abnormal_mitochondrial_physio0.69134094
104MP0010678_abnormal_skin_adnexa0.69017997
105MP0005621_abnormal_cell_physiology0.68229512
106MP0000647_abnormal_sebaceous_gland0.67716464
107MP0010030_abnormal_orbit_morphology0.67234850
108MP0001929_abnormal_gametogenesis0.66781752
109MP0000767_abnormal_smooth_muscle0.66532150
110MP0002429_abnormal_blood_cell0.64799996
111MP0002877_abnormal_melanocyte_morpholog0.64307758
112MP0000371_diluted_coat_color0.63957165
113MP0005391_vision/eye_phenotype0.63892568
114MP0005410_abnormal_fertilization0.62808605
115MP0008770_decreased_survivor_rate0.62806046
116MP0000579_abnormal_nail_morphology0.62642509
117MP0005395_other_phenotype0.62169215
118MP0003656_abnormal_erythrocyte_physiolo0.60843508
119MP0001529_abnormal_vocalization0.60527204
120MP0003861_abnormal_nervous_system0.60036406
121MP0002161_abnormal_fertility/fecundity0.59423495
122MP0005464_abnormal_platelet_physiology0.59294268
123MP0000383_abnormal_hair_follicle0.58962589
124MP0003828_pulmonary_edema0.58133455
125MP0000266_abnormal_heart_morphology0.57123231
126MP0009703_decreased_birth_body0.56905896
127MP0009672_abnormal_birth_weight0.56338081
128MP0003937_abnormal_limbs/digits/tail_de0.55603797
129MP0001286_abnormal_eye_development0.55250014
130MP0002932_abnormal_joint_morphology0.54813931
131MP0002269_muscular_atrophy0.54343997
132MP0003787_abnormal_imprinting0.54214258
133MP0010234_abnormal_vibrissa_follicle0.53803894
134MP0001188_hyperpigmentation0.53755177
135MP0005187_abnormal_penis_morphology0.53607291
136MP0002111_abnormal_tail_morphology0.51423710

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the musculature of the pelvis (HP:0001469)5.18752374
2Abnormality of the hip-girdle musculature (HP:0001445)5.18752374
3Limb-girdle muscle atrophy (HP:0003797)4.31280777
4Colon cancer (HP:0003003)4.27214956
5Birth length less than 3rd percentile (HP:0003561)4.10193985
6Medulloblastoma (HP:0002885)3.57714411
7Abnormality of chromosome stability (HP:0003220)3.54272582
8Ependymoma (HP:0002888)3.48138763
9Meckel diverticulum (HP:0002245)3.37217370
10Selective tooth agenesis (HP:0001592)3.34803348
11Agnosia (HP:0010524)3.34258508
12Myelodysplasia (HP:0002863)3.32837032
13Volvulus (HP:0002580)3.25833486
14Abnormality of the ileum (HP:0001549)3.17503026
15Neoplasm of the oral cavity (HP:0100649)3.11813388
16Breast hypoplasia (HP:0003187)3.10343639
17Abnormality of the preputium (HP:0100587)3.10062883
18Cortical dysplasia (HP:0002539)3.08757087
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.07194657
20Supernumerary spleens (HP:0009799)3.03753069
21Aplastic anemia (HP:0001915)3.02024520
22Small intestinal stenosis (HP:0012848)2.99141067
23Duodenal stenosis (HP:0100867)2.99141067
24Rhabdomyosarcoma (HP:0002859)2.83931408
25Basal cell carcinoma (HP:0002671)2.68538891
26Amaurosis fugax (HP:0100576)2.58409638
27Abnormality of the duodenum (HP:0002246)2.56363562
28Abnormality of the astrocytes (HP:0100707)2.54672292
29Astrocytoma (HP:0009592)2.54672292
30Glioma (HP:0009733)2.53737986
31Chromsome breakage (HP:0040012)2.53734404
32Abnormal lung lobation (HP:0002101)2.53299778
33Abnormal number of incisors (HP:0011064)2.52453914
34Limb-girdle muscle weakness (HP:0003325)2.47883307
35Short 4th metacarpal (HP:0010044)2.45682227
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45682227
37Abnormality of the carotid arteries (HP:0005344)2.45491551
38Nephroblastoma (Wilms tumor) (HP:0002667)2.44360999
39Reticulocytopenia (HP:0001896)2.42653963
40Increased nuchal translucency (HP:0010880)2.41538312
41Papillary thyroid carcinoma (HP:0002895)2.40759116
42Bone marrow hypocellularity (HP:0005528)2.37489815
43Ectopic kidney (HP:0000086)2.33210249
44Abnormality of the labia minora (HP:0012880)2.31736529
45Biliary tract neoplasm (HP:0100574)2.31574410
46Acute myeloid leukemia (HP:0004808)2.30537972
47Thrombocytosis (HP:0001894)2.30159075
48Embryonal renal neoplasm (HP:0011794)2.27285319
49IgM deficiency (HP:0002850)2.26304992
50Absent radius (HP:0003974)2.24614471
51Spastic diplegia (HP:0001264)2.24086411
52Microglossia (HP:0000171)2.23731656
53Sloping forehead (HP:0000340)2.22086465
54Fair hair (HP:0002286)2.21608061
55Supernumerary bones of the axial skeleton (HP:0009144)2.21524361
56Patellar aplasia (HP:0006443)2.17884207
57Neoplasm of striated muscle (HP:0009728)2.16425692
58Supernumerary ribs (HP:0005815)2.15786542
59Inappropriate behavior (HP:0000719)2.11236311
60Benign neoplasm of the central nervous system (HP:0100835)2.10777444
61Progressive muscle weakness (HP:0003323)2.10014533
62Pancreatic islet-cell hyperplasia (HP:0004510)2.08768756
63Type 2 muscle fiber atrophy (HP:0003554)2.08687347
64Premature graying of hair (HP:0002216)2.08314637
65Abnormality of cells of the erythroid lineage (HP:0012130)2.06851262
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06640096
67Cafe-au-lait spot (HP:0000957)2.06392426
68Proximal placement of thumb (HP:0009623)2.06283920
69Aplasia/Hypoplasia of the patella (HP:0006498)2.06200353
70Aplasia involving forearm bones (HP:0009822)2.05120764
71Absent forearm bone (HP:0003953)2.05120764
72Central scotoma (HP:0000603)2.03402894
73Facial cleft (HP:0002006)2.02239577
74Muscle fiber atrophy (HP:0100295)2.01949143
75Clubbing of toes (HP:0100760)2.01622400
76Truncal obesity (HP:0001956)1.98986141
77Acute lymphatic leukemia (HP:0006721)1.98463759
78Hypoplasia of the pons (HP:0012110)1.96746982
79Microvesicular hepatic steatosis (HP:0001414)1.96607385
80Meningioma (HP:0002858)1.95637719
81Impulsivity (HP:0100710)1.95488322
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.95011778
83Absent/shortened dynein arms (HP:0200106)1.95011778
84Neoplasm of the rectum (HP:0100743)1.94571519
85Absent thumb (HP:0009777)1.94429020
8611 pairs of ribs (HP:0000878)1.94402811
87Deviation of the thumb (HP:0009603)1.94096139
88Deep philtrum (HP:0002002)1.93934736
89Cutaneous melanoma (HP:0012056)1.93848219
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.92404964
91Pelvic girdle muscle weakness (HP:0003749)1.90760327
92Neoplasm of the colon (HP:0100273)1.90636607
93Neurodegeneration (HP:0002180)1.90057451
94Neoplasm of the small intestine (HP:0100833)1.89894987
95Ovarian neoplasm (HP:0100615)1.89169569
96Thyroid carcinoma (HP:0002890)1.88865220
97Gastrointestinal carcinoma (HP:0002672)1.88762317
98Malignant gastrointestinal tract tumors (HP:0006749)1.88762317
99Abnormal number of erythroid precursors (HP:0012131)1.88339836
100Protruding tongue (HP:0010808)1.86490980
101Urethral obstruction (HP:0000796)1.86445852
102Horseshoe kidney (HP:0000085)1.85546285
103Proximal amyotrophy (HP:0007126)1.85233813
104Petechiae (HP:0000967)1.84554289
105Ankyloglossia (HP:0010296)1.83693644
106Shoulder girdle muscle weakness (HP:0003547)1.83064948
107Amyotrophic lateral sclerosis (HP:0007354)1.83002547
108Uterine neoplasm (HP:0010784)1.81981626
109Multiple enchondromatosis (HP:0005701)1.80614073
110Neoplasm of the pancreas (HP:0002894)1.79902593
111Oral leukoplakia (HP:0002745)1.79340286
112Aplasia/hypoplasia of the humerus (HP:0006507)1.77822458
113Hemivertebrae (HP:0002937)1.77512059
114Capillary hemangiomas (HP:0005306)1.77044921
115Short 5th finger (HP:0009237)1.77023543
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.76543029
117Carpal bone hypoplasia (HP:0001498)1.76366559
118Choanal atresia (HP:0000453)1.76106561
119Arteriovenous malformation (HP:0100026)1.76084279
120Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76011821
121Duplicated collecting system (HP:0000081)1.75725847
122Generalized hypopigmentation of hair (HP:0011358)1.75614335
123Tracheoesophageal fistula (HP:0002575)1.75442307
124Abnormality of the pons (HP:0007361)1.75332592
125Degeneration of anterior horn cells (HP:0002398)1.74666867
126Abnormality of the anterior horn cell (HP:0006802)1.74666867
127Abnormality of methionine metabolism (HP:0010901)1.72988286
128Abnormality of DNA repair (HP:0003254)1.71928510
129Embryonal neoplasm (HP:0002898)1.71607170
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71022535
131Short middle phalanx of the 5th finger (HP:0004220)1.70952554
132Chronic bronchitis (HP:0004469)1.70727675
133Missing ribs (HP:0000921)1.70550495
134Triphalangeal thumb (HP:0001199)1.70413724
135Postnatal microcephaly (HP:0005484)1.70361052
136Microretrognathia (HP:0000308)1.69783511
137Scotoma (HP:0000575)1.69065269
138High pitched voice (HP:0001620)1.68581367
139Abnormal ciliary motility (HP:0012262)1.67481383
140Progressive external ophthalmoplegia (HP:0000590)1.65710795
141Abnormal respiratory motile cilium physiology (HP:0012261)1.64959030
142Abnormal respiratory epithelium morphology (HP:0012253)1.62239181
143Abnormal respiratory motile cilium morphology (HP:0005938)1.62239181
144Leiomyosarcoma (HP:0100243)1.60703124
145Uterine leiomyosarcoma (HP:0002891)1.60703124
146Increased mean platelet volume (HP:0011877)1.60595490
147Abnormal auditory evoked potentials (HP:0006958)1.59257751
148Rimmed vacuoles (HP:0003805)1.59197736
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58508137
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57942205
151Abnormality of alanine metabolism (HP:0010916)1.57674169
152Hyperalaninemia (HP:0003348)1.57674169
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57674169
154Breast carcinoma (HP:0003002)1.57551421
155Squamous cell carcinoma (HP:0002860)1.56664210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.80123126
2WEE14.45470204
3BRSK23.64076628
4CDC73.51068559
5PBK3.08759655
6MKNK12.83003707
7TGFBR12.56793005
8TSSK62.30626570
9MKNK22.25893943
10CDK72.25176213
11TIE12.20451371
12STK162.14401512
13ACVR1B2.13622784
14NEK12.12140520
15KDR2.07987469
16TAF11.96057937
17BRSK11.83291479
18CAMKK21.78191250
19NEK21.78021532
20SRPK11.74255107
21MAP3K81.72413124
22VRK11.69761915
23RPS6KA41.67553945
24LATS11.63825802
25ATR1.63733923
26FLT31.59341269
27CCNB11.59271908
28NME21.58916823
29PLK31.58178908
30RPS6KB21.54329573
31PLK11.50641327
32TTK1.49466297
33EIF2AK11.48901768
34NUAK11.48708226
35PASK1.42959076
36MUSK1.40702989
37STK31.35251463
38CHEK21.32456078
39SCYL21.32135807
40CDK41.30602838
41PKN21.29036227
42PLK41.28572566
43PNCK1.27471379
44AURKB1.16845646
45VRK21.16106895
46CDK81.10219584
47BTK1.08819701
48EEF2K1.07721982
49BMPR1B1.06410758
50PAK41.05644266
51CSF1R1.03786011
52MET1.00954023
53DYRK30.99860153
54BCR0.99744503
55MAP3K100.99415659
56STK38L0.97981564
57CDK60.96820211
58EIF2AK20.91254872
59ZAK0.88815912
60ALK0.87944201
61MAP4K10.87269041
62NME10.86065520
63PIM10.84759158
64CHEK10.81064532
65ERBB40.79134171
66CDK120.79017506
67RPS6KB10.78711683
68AURKA0.75388527
69ATM0.74928686
70JAK30.72163583
71BRAF0.71828791
72CDK190.71196348
73CAMK1G0.69958133
74CDK20.69461942
75CLK10.68305413
76ERBB30.68111485
77TRIM280.65507550
78CSNK1G30.65120817
79BMX0.65106555
80KIT0.64520418
81CAMKK10.63153144
82LATS20.62601022
83PDK40.62053962
84PDK30.62053962
85AKT30.62032126
86SMG10.61536094
87CDK30.60176689
88MST1R0.58478010
89STK40.58051204
90DAPK10.57165004
91CDK90.56905827
92MST40.56578559
93NEK90.56419868
94PDK10.55410713
95MAP2K30.54351166
96EIF2AK30.54115139
97CSNK1G10.52803226
98CSNK2A20.52295698
99CSNK1A1L0.51072969
100RPS6KL10.50133680
101RPS6KC10.50133680
102STK110.49693306
103MAP3K40.47919257
104MAP3K120.47196832
105AKT20.46668277
106CDK10.44623131
107CSNK2A10.43908533
108RPS6KA60.43581741
109RAF10.43236985
110BRD40.43060559
111MATK0.42886405
112FGFR10.41244155
113TLK10.39832420
114TEC0.39468342
115CSNK1G20.38625275
116PDK20.38447283
117KSR10.36966369
118PRKDC0.36242143
119MELK0.36180674
120PAK10.34523556
121TAOK20.34096778
122CSNK1E0.33932656
123MAP4K20.32646314
124PAK20.32317629
125STK100.32111066
126STK240.31842139
127RPS6KA50.31656317
128RPS6KA20.30659124
129PLK20.29972832
130MAPK40.29023221
131SYK0.28551930
132FER0.28087831
133YES10.27993527
134PIM20.27418491

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74517188
2Mismatch repair_Homo sapiens_hsa034304.24612633
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44448293
4RNA transport_Homo sapiens_hsa030133.38560010
5Spliceosome_Homo sapiens_hsa030403.24599641
6Cell cycle_Homo sapiens_hsa041103.02418628
7Homologous recombination_Homo sapiens_hsa034402.73092935
8Nucleotide excision repair_Homo sapiens_hsa034202.70323555
9Ribosome_Homo sapiens_hsa030102.70038464
10Fanconi anemia pathway_Homo sapiens_hsa034602.64540905
11Base excision repair_Homo sapiens_hsa034102.60389850
12RNA polymerase_Homo sapiens_hsa030202.48739566
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44085675
14Proteasome_Homo sapiens_hsa030502.07913871
15RNA degradation_Homo sapiens_hsa030182.01485112
16Pyrimidine metabolism_Homo sapiens_hsa002401.96358636
17mRNA surveillance pathway_Homo sapiens_hsa030151.89308022
18Non-homologous end-joining_Homo sapiens_hsa034501.89029929
19One carbon pool by folate_Homo sapiens_hsa006701.87546395
20Oocyte meiosis_Homo sapiens_hsa041141.83636274
21Basal transcription factors_Homo sapiens_hsa030221.68889520
22Systemic lupus erythematosus_Homo sapiens_hsa053221.68224880
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50176198
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48515618
25p53 signaling pathway_Homo sapiens_hsa041151.47949184
26Viral carcinogenesis_Homo sapiens_hsa052031.41444656
27Pyruvate metabolism_Homo sapiens_hsa006201.34219542
28Purine metabolism_Homo sapiens_hsa002301.27647030
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25493106
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21464964
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13294495
32Carbon metabolism_Homo sapiens_hsa012001.11735368
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10377693
34Thyroid cancer_Homo sapiens_hsa052161.09113879
35HTLV-I infection_Homo sapiens_hsa051661.07546584
36Viral myocarditis_Homo sapiens_hsa054161.06912085
37Epstein-Barr virus infection_Homo sapiens_hsa051691.06448250
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05381695
39Propanoate metabolism_Homo sapiens_hsa006401.04932984
40Protein export_Homo sapiens_hsa030601.02498872
41Alcoholism_Homo sapiens_hsa050340.97787556
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94444712
43mTOR signaling pathway_Homo sapiens_hsa041500.93211942
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93092725
45Antigen processing and presentation_Homo sapiens_hsa046120.92224573
46MicroRNAs in cancer_Homo sapiens_hsa052060.92084375
47Herpes simplex infection_Homo sapiens_hsa051680.88102748
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86721152
49Glutathione metabolism_Homo sapiens_hsa004800.83754142
50Steroid biosynthesis_Homo sapiens_hsa001000.83296286
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80299880
52Vitamin B6 metabolism_Homo sapiens_hsa007500.76299770
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76024541
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75216277
55Fatty acid elongation_Homo sapiens_hsa000620.69712701
56Nitrogen metabolism_Homo sapiens_hsa009100.69663631
57Long-term potentiation_Homo sapiens_hsa047200.68641620
58Small cell lung cancer_Homo sapiens_hsa052220.66607587
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65911852
60Chronic myeloid leukemia_Homo sapiens_hsa052200.64362589
61Colorectal cancer_Homo sapiens_hsa052100.64014500
62Shigellosis_Homo sapiens_hsa051310.63547276
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60673799
64Huntingtons disease_Homo sapiens_hsa050160.60374925
65HIF-1 signaling pathway_Homo sapiens_hsa040660.59815245
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.59580292
67Platelet activation_Homo sapiens_hsa046110.59440417
68Hepatitis B_Homo sapiens_hsa051610.58631749
69Lysine degradation_Homo sapiens_hsa003100.57892725
70Non-small cell lung cancer_Homo sapiens_hsa052230.57481605
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57203377
72Biosynthesis of amino acids_Homo sapiens_hsa012300.55228160
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55012706
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.54827202
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53610201
76Acute myeloid leukemia_Homo sapiens_hsa052210.53367284
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52041745
78Arginine and proline metabolism_Homo sapiens_hsa003300.51144748
79Primary immunodeficiency_Homo sapiens_hsa053400.50371005
80Folate biosynthesis_Homo sapiens_hsa007900.48824121
81B cell receptor signaling pathway_Homo sapiens_hsa046620.48068615
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.46426394
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46180610
84N-Glycan biosynthesis_Homo sapiens_hsa005100.46049324
85Pathways in cancer_Homo sapiens_hsa052000.45698250
86Legionellosis_Homo sapiens_hsa051340.45359393
87Notch signaling pathway_Homo sapiens_hsa043300.45072101
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44698104
89Hippo signaling pathway_Homo sapiens_hsa043900.42059226
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41151942
91Fatty acid biosynthesis_Homo sapiens_hsa000610.41090241
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.39328732
93Basal cell carcinoma_Homo sapiens_hsa052170.39046362
94Prostate cancer_Homo sapiens_hsa052150.38130779
95Metabolic pathways_Homo sapiens_hsa011000.37566078
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35697261
97TGF-beta signaling pathway_Homo sapiens_hsa043500.35542129
98Measles_Homo sapiens_hsa051620.35255847
99Selenocompound metabolism_Homo sapiens_hsa004500.34927104
100Fatty acid metabolism_Homo sapiens_hsa012120.34808603
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34438644
102Rap1 signaling pathway_Homo sapiens_hsa040150.34085086
103Wnt signaling pathway_Homo sapiens_hsa043100.33811512
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32503745
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31714463
106Sulfur relay system_Homo sapiens_hsa041220.31081493
107Bladder cancer_Homo sapiens_hsa052190.30661674
108Pancreatic cancer_Homo sapiens_hsa052120.29265023
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28774454
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28721483
111Proteoglycans in cancer_Homo sapiens_hsa052050.28559872
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28334857
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26549723
114Apoptosis_Homo sapiens_hsa042100.26242847
115Adherens junction_Homo sapiens_hsa045200.25477976
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25374626
117ECM-receptor interaction_Homo sapiens_hsa045120.25036601
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24205558
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24145470
120FoxO signaling pathway_Homo sapiens_hsa040680.23435006
121beta-Alanine metabolism_Homo sapiens_hsa004100.22257661
122Glioma_Homo sapiens_hsa052140.20248979
123Arginine biosynthesis_Homo sapiens_hsa002200.19932915
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.19892780
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19272323
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18039353
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17562830
128Melanoma_Homo sapiens_hsa052180.17230013
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.17170893
130Pentose phosphate pathway_Homo sapiens_hsa000300.16906843
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16679791
132African trypanosomiasis_Homo sapiens_hsa051430.16645644
133Renin-angiotensin system_Homo sapiens_hsa046140.16436965
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15085071
135Focal adhesion_Homo sapiens_hsa045100.14933165
136Hedgehog signaling pathway_Homo sapiens_hsa043400.14724568
137Tight junction_Homo sapiens_hsa045300.14268093
138Fructose and mannose metabolism_Homo sapiens_hsa000510.13133285
139ErbB signaling pathway_Homo sapiens_hsa040120.12967591

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