IP6K3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.64965082
2plasma membrane repair (GO:0001778)9.10392967
3skeletal muscle contraction (GO:0003009)9.09475583
4sarcoplasmic reticulum calcium ion transport (GO:0070296)8.95767797
5negative regulation of cardiac muscle tissue growth (GO:0055022)8.25690181
6negative regulation of heart growth (GO:0061117)8.25690181
7negative regulation of cardiac muscle hypertrophy (GO:0010614)8.17020880
8ribonucleoprotein complex disassembly (GO:0032988)8.02132047
9negative regulation of organelle assembly (GO:1902116)8.00074814
10activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO7.82367245
11membrane raft organization (GO:0031579)7.76652384
12sarcomere organization (GO:0045214)7.76227454
13negative regulation of cell size (GO:0045792)7.74033318
14actin filament-based movement (GO:0030048)7.30265318
15positive regulation of microtubule polymerization (GO:0031116)6.85320119
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.85284086
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.76342454
18skeletal muscle adaptation (GO:0043501)6.75857659
19positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.71533799
20negative regulation of monooxygenase activity (GO:0032769)6.68236225
21myofibril assembly (GO:0030239)6.63066064
22striated muscle contraction (GO:0006941)6.53886524
23organelle disassembly (GO:1903008)6.30545517
24skeletal muscle fiber development (GO:0048741)6.29055155
25membrane assembly (GO:0071709)6.17405082
26regulation of action potential (GO:0098900)6.17063443
27negative regulation of cardiac muscle tissue development (GO:0055026)5.94361320
28negative regulation of potassium ion transmembrane transport (GO:1901380)5.78322782
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.74574766
30regulation of cardiac muscle cell differentiation (GO:2000725)5.74196263
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.55238598
32pyrimidine ribonucleoside catabolic process (GO:0046133)5.46737723
33regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.40176151
34heart trabecula formation (GO:0060347)5.39034785
35muscle contraction (GO:0006936)5.36240078
36cardiac myofibril assembly (GO:0055003)5.35536172
37myotube cell development (GO:0014904)5.35382328
38cytidine deamination (GO:0009972)5.31987557
39cytidine metabolic process (GO:0046087)5.31987557
40cytidine catabolic process (GO:0006216)5.31987557
41creatine metabolic process (GO:0006600)5.28441774
42regulation of cell communication by electrical coupling (GO:0010649)5.27870438
43actomyosin structure organization (GO:0031032)5.21794935
44cardiac muscle contraction (GO:0060048)5.05126755
45carnitine shuttle (GO:0006853)5.04899523
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.97384241
47response to inactivity (GO:0014854)4.86089089
48regulation of relaxation of muscle (GO:1901077)4.85448845
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.81982708
50muscle system process (GO:0003012)4.79663029
51positive regulation of microtubule polymerization or depolymerization (GO:0031112)4.79534255
52primary alcohol catabolic process (GO:0034310)4.76586343
53response to muscle activity (GO:0014850)4.73311184
54regulation of protein localization to cell surface (GO:2000008)4.63236122
55regulation of muscle hypertrophy (GO:0014743)4.52852733
56skeletal muscle tissue regeneration (GO:0043403)4.49912401
57regulation of alkaline phosphatase activity (GO:0010692)4.49594633
58muscle fiber development (GO:0048747)4.46996658
59glycogen catabolic process (GO:0005980)4.42663230
60cytoplasmic microtubule organization (GO:0031122)4.41563760
61regulation of acyl-CoA biosynthetic process (GO:0050812)4.36894885
62tricarboxylic acid cycle (GO:0006099)4.32398479
63striated muscle atrophy (GO:0014891)4.30832293
64cardiac muscle cell development (GO:0055013)4.27823138
65striated muscle adaptation (GO:0014888)4.27313161
66myotube differentiation (GO:0014902)4.25835226
67fatty acid transmembrane transport (GO:1902001)4.23546991
68muscle cell fate commitment (GO:0042693)4.21284555
69regulation of transforming growth factor beta2 production (GO:0032909)4.18402187
70regulation of potassium ion transmembrane transporter activity (GO:1901016)4.13062486
71glucan catabolic process (GO:0009251)4.12060750
72regulation of actin filament-based movement (GO:1903115)4.11754007
73cardiac cell development (GO:0055006)4.03440032
74positive regulation of myoblast differentiation (GO:0045663)4.01763181
75regulation of striated muscle contraction (GO:0006942)4.00734072
76regulation of cofactor metabolic process (GO:0051193)3.99506264
77regulation of coenzyme metabolic process (GO:0051196)3.99506264
78glycogen biosynthetic process (GO:0005978)3.96076156
79glucan biosynthetic process (GO:0009250)3.96076156
80striated muscle cell development (GO:0055002)3.94730469
81regulation of membrane repolarization (GO:0060306)3.93140537
82muscle cell cellular homeostasis (GO:0046716)3.90626356
83positive regulation of striated muscle cell differentiation (GO:0051155)3.89763387
84negative regulation of striated muscle cell differentiation (GO:0051154)3.87247551
85cellular polysaccharide catabolic process (GO:0044247)3.80144497
86regulation of cardiac muscle hypertrophy (GO:0010611)3.77648900
87carnitine transmembrane transport (GO:1902603)3.76929223
88regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.76169943
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.75069595
90regulation of skeletal muscle cell differentiation (GO:2001014)3.71889615
91intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.68892749
92polysaccharide catabolic process (GO:0000272)3.65667028
93negative regulation of striated muscle tissue development (GO:0045843)3.62828723
94muscle organ development (GO:0007517)3.61868060
95ventricular cardiac muscle cell action potential (GO:0086005)3.61122621
96positive regulation of myotube differentiation (GO:0010831)3.58779707
97muscle structure development (GO:0061061)3.57561579
98muscle atrophy (GO:0014889)3.56929325
99nucleus localization (GO:0051647)3.56256039
100negative regulation of muscle tissue development (GO:1901862)3.53825698
101regulation of calcium ion transmembrane transporter activity (GO:1901019)3.53434213
102regulation of calcium ion transmembrane transport (GO:1903169)3.53434213
103regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53355929
104myoblast fusion (GO:0007520)3.53235924
105muscle adaptation (GO:0043500)3.51368600
106positive regulation of extracellular matrix organization (GO:1903055)3.50414303
107muscle tissue morphogenesis (GO:0060415)3.48864630
108cardiac muscle tissue morphogenesis (GO:0055008)3.48824093
109striated muscle hypertrophy (GO:0014897)3.48085205
110cardiac muscle cell action potential involved in contraction (GO:0086002)3.47817382
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.47782473
112negative regulation of oxidoreductase activity (GO:0051354)3.46575752
113cardiac muscle cell action potential (GO:0086001)3.43299354
114cardiac muscle hypertrophy (GO:0003300)3.43295897
115regulation of calcium ion import (GO:0090279)3.42392582
116amino-acid betaine transport (GO:0015838)3.41899430
117carnitine transport (GO:0015879)3.41899430
118regulation of muscle adaptation (GO:0043502)3.41114687
119SMAD protein complex assembly (GO:0007183)3.37640070
120negative regulation of protein localization to cell surface (GO:2000009)3.36904702
121negative regulation of muscle organ development (GO:0048635)3.36848933
122postreplication repair (GO:0006301)3.36523531
123muscle cell development (GO:0055001)3.35817016
124heart process (GO:0003015)3.35608283
125heart contraction (GO:0060047)3.35608283
126skeletal muscle tissue development (GO:0007519)3.32664462
127negative regulation of organ growth (GO:0046621)3.32584760
128regulation of potassium ion transmembrane transport (GO:1901379)3.31663616
129regulation of p38MAPK cascade (GO:1900744)3.30660999
130regulation of sarcomere organization (GO:0060297)3.30072793
131pericardium development (GO:0060039)3.27710754
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.26813566
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.26636531
134adult heart development (GO:0007512)3.25741868
135regulation of membrane depolarization (GO:0003254)3.24342099
136lens fiber cell differentiation (GO:0070306)3.24103512
137negative regulation of potassium ion transport (GO:0043267)3.23912485
138glycogen metabolic process (GO:0005977)3.23847562
139syncytium formation by plasma membrane fusion (GO:0000768)3.20499606
140trabecula formation (GO:0060343)3.19732635
141regulation of microtubule polymerization (GO:0031113)3.18776880
142syncytium formation (GO:0006949)3.18292427
143cellular glucan metabolic process (GO:0006073)3.16679232
144glucan metabolic process (GO:0044042)3.16679232
145regulation of muscle contraction (GO:0006937)3.16356638
146negative regulation of muscle hypertrophy (GO:0014741)3.16112286
147negative regulation of ion transmembrane transporter activity (GO:0032413)3.16070268
148regulation of sulfur metabolic process (GO:0042762)3.14084509
149positive regulation of skeletal muscle tissue development (GO:0048643)3.11581223
150embryonic viscerocranium morphogenesis (GO:0048703)3.09724594
151response to activity (GO:0014823)3.09331401
152regulation of muscle system process (GO:0090257)3.08541342
153muscle filament sliding (GO:0030049)11.7639117
154actin-myosin filament sliding (GO:0033275)11.7639117
155negative regulation of nitric-oxide synthase activity (GO:0051001)10.3723632
156regulation of skeletal muscle contraction (GO:0014819)10.0745486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human7.89594930
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.15364170
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.15364170
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.15364170
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.99268643
6GATA1_22025678_ChIP-Seq_K562_Human4.14121210
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.13154804
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.22855278
9IGF1R_20145208_ChIP-Seq_DFB_Human2.96685950
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95491736
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.95342835
12* TBX20_22328084_ChIP-Seq_HEART_Mouse2.94101268
13* TBX20_22080862_ChIP-Seq_HEART_Mouse2.94101268
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89975893
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.60299053
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.44049724
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.36200060
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35446236
19ZNF263_19887448_ChIP-Seq_K562_Human2.29319979
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24376770
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07318647
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.06483106
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.05133799
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99765562
25MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.96511736
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.87307755
27* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83825585
28NFIB_24661679_ChIP-Seq_LUNG_Mouse1.72248072
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70395859
30CTCF_27219007_Chip-Seq_Bcells_Human1.60985610
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57501498
32CLOCK_20551151_ChIP-Seq_293T_Human1.56973303
33RUNX1_26923725_Chip-Seq_HPCs_Mouse1.48786497
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48422806
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48207095
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.47793479
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.46876588
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45794045
39DROSHA_22980978_ChIP-Seq_HELA_Human1.45237866
40AR_21572438_ChIP-Seq_LNCaP_Human1.43194329
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42315208
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42163837
43* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42062549
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38743240
45* LXR_22292898_ChIP-Seq_THP-1_Human1.38060411
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37919594
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36011076
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35072854
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33546877
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31742938
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31517083
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30792276
53SPI1_20517297_ChIP-Seq_HL60_Human1.30263791
54LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29354310
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28235187
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27749100
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26622928
58KDM2B_26808549_Chip-Seq_DND41_Human1.24149470
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23647784
60RACK7_27058665_Chip-Seq_MCF-7_Human1.23600932
61* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23507786
62* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21955827
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20442995
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19893610
65GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18510843
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18142588
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14984073
68CJUN_26792858_Chip-Seq_BT549_Human1.14856392
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.14399581
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13344140
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12258745
72* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11608444
73RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11424147
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.10040185
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09825551
76* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09087983
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08947278
78* TP63_22573176_ChIP-Seq_HFKS_Human1.07961779
79* CTCF_21964334_Chip-Seq_Bcells_Human1.07564827
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07380591
81SA1_27219007_Chip-Seq_Bcells_Human1.06923804
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06171239
83KDM2B_26808549_Chip-Seq_K562_Human1.06049932
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.05999917
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05741680
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05535402
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05479426
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05104127
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05044797
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04448084
91FOXH1_21741376_ChIP-Seq_ESCs_Human1.03862897
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03639842
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03038935
94* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02792231
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.02561027
96ATF3_27146783_Chip-Seq_COLON_Human1.02233230
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02144124
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01841120
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.01429727
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.99680780
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98407349
102MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97803595
103TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97099113
104P68_20966046_ChIP-Seq_HELA_Human0.96899992
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96626955
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.96579792
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95604875
108FUS_26573619_Chip-Seq_HEK293_Human0.94116254
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93627129
110ZNF274_21170338_ChIP-Seq_K562_Hela0.93580841
111SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93427817
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92865065
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92755927
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92509965
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91805459
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91468685
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.90707434
118RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89502686
119EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89502686
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89205616
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88868834
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88421932
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87111536
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86323865
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86077522
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86073947
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85280010
128EZH2_22144423_ChIP-Seq_EOC_Human0.85232839
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84951561
130BCL6_27268052_Chip-Seq_Bcells_Human0.84341337
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84302060
132* OCT4_20526341_ChIP-Seq_ESCs_Human0.84023950
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83706134
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83673905
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.83387720
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82955441
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82786960
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82371170
139EGR1_19032775_ChIP-ChIP_M12_Human0.82347916
140POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82319359
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.81981085
142P53_22387025_ChIP-Seq_ESCs_Mouse0.81448461
143ERG_20517297_ChIP-Seq_VCAP_Human0.81258614
144SMC4_20622854_ChIP-Seq_HELA_Human0.81219429
145BRD4_25478319_ChIP-Seq_HGPS_Human0.80874032
146CREB1_26743006_Chip-Seq_LNCaP_Human0.80048639
147CBP_20019798_ChIP-Seq_JUKART_Human0.79276869
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77831908
149LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76311367
150ER_23166858_ChIP-Seq_MCF-7_Human0.76221946
151HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75239381
152TP53_18474530_ChIP-ChIP_U2OS_Human0.74981569
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73140373
154SOX11_22085726_ChIP-Seq_ESNs_Mouse0.72080326
155* PIAS1_25552417_ChIP-Seq_VCAP_Human0.71736543
156MYC_19915707_ChIP-ChIP_AK7_Human0.68179428
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.67832695
158PU1_27457419_Chip-Seq_LIVER_Mouse0.67459750
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66669885
160OCT4_18555785_Chip-Seq_ESCs_Mouse0.65548150
161CBX2_27304074_Chip-Seq_ESCs_Mouse0.65465904
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65192798
163POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.65150254
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65150254
165TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64093624
166SMAD4_21799915_ChIP-Seq_A2780_Human0.63112203
167SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.62667184
168RUNX1_27457419_Chip-Seq_LIVER_Mouse0.62504498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy6.21110904
2MP0003646_muscle_fatigue6.18226489
3MP0000749_muscle_degeneration5.89264811
4MP0004145_abnormal_muscle_electrophysio5.55817768
5MP0002837_dystrophic_cardiac_calcinosis5.17257984
6MP0004036_abnormal_muscle_relaxation4.04009926
7MP0000747_muscle_weakness3.80151298
8MP0002106_abnormal_muscle_physiology3.78258250
9MP0004087_abnormal_muscle_fiber3.51801803
10MP0004084_abnormal_cardiac_muscle3.45134900
11MP0000750_abnormal_muscle_regeneration3.39341339
12MP0002102_abnormal_ear_morphology3.38599463
13MP0000759_abnormal_skeletal_muscle3.32540730
14MP0005369_muscle_phenotype3.13877287
15MP0002269_muscular_atrophy3.10786466
16MP0005620_abnormal_muscle_contractility2.99140230
17MP0004215_abnormal_myocardial_fiber2.88547119
18MP0005330_cardiomyopathy2.79787627
19MP0004130_abnormal_muscle_cell2.72244750
20MP0004233_abnormal_muscle_weight2.45972715
21MP0000733_abnormal_muscle_development2.11939495
22MP0002972_abnormal_cardiac_muscle2.04096460
23MP0002332_abnormal_exercise_endurance1.97870922
24MP0004484_altered_response_of1.87189983
25MP0002108_abnormal_muscle_morphology1.77591180
26MP0010630_abnormal_cardiac_muscle1.76462177
27MP0009780_abnormal_chondrocyte_physiolo1.69430284
28MP0003137_abnormal_impulse_conducting1.65529110
29MP0004185_abnormal_adipocyte_glucose1.56722788
30MP0006036_abnormal_mitochondrial_physio1.54792364
31MP0001544_abnormal_cardiovascular_syste1.54468938
32MP0005385_cardiovascular_system_phenoty1.54468938
33MP0005666_abnormal_adipose_tissue1.49792847
34MP0008789_abnormal_olfactory_epithelium1.48716825
35MP0008775_abnormal_heart_ventricle1.48619714
36MP0004510_myositis1.48579887
37MP0003950_abnormal_plasma_membrane1.39467919
38MP0005187_abnormal_penis_morphology1.36859322
39MP0000467_abnormal_esophagus_morphology1.25595213
40MP0002971_abnormal_brown_adipose1.25164146
41MP0010030_abnormal_orbit_morphology1.22524822
42MP0006138_congestive_heart_failure1.22185486
43MP0003221_abnormal_cardiomyocyte_apopto1.21916309
44MP0001873_stomach_inflammation1.19100915
45MP0001542_abnormal_bone_strength1.17577918
46MP0005375_adipose_tissue_phenotype1.14920277
47MP0003705_abnormal_hypodermis_morpholog1.14315947
48MP0002234_abnormal_pharynx_morphology1.12310670
49MP0004883_abnormal_blood_vessel1.10702233
50MP0000013_abnormal_adipose_tissue1.04220717
51MP0001293_anophthalmia1.02458029
52MP0005499_abnormal_olfactory_system0.98467451
53MP0005394_taste/olfaction_phenotype0.98467451
54MP0003828_pulmonary_edema0.97917401
55MP0001485_abnormal_pinna_reflex0.97486754
56MP0005670_abnormal_white_adipose0.95460259
57MP0002249_abnormal_larynx_morphology0.89748158
58MP0004085_abnormal_heartbeat0.88930298
59MP0000343_altered_response_to0.87931870
60MP0004270_analgesia0.87599112
61MP0000569_abnormal_digit_pigmentation0.86338442
62MP0005266_abnormal_metabolism0.83029013
63MP0002254_reproductive_system_inflammat0.79974854
64MP0005275_abnormal_skin_tensile0.79583487
65MP0002127_abnormal_cardiovascular_syste0.78401936
66MP0008438_abnormal_cutaneous_collagen0.77602131
67MP0000003_abnormal_adipose_tissue0.77411138
68MP0000266_abnormal_heart_morphology0.70247270
69MP0003453_abnormal_keratinocyte_physiol0.67695011
70MP0008961_abnormal_basal_metabolism0.64597516
71MP0001299_abnormal_eye_distance/0.63170822
72MP0006035_abnormal_mitochondrial_morpho0.62654709
73MP0003045_fibrosis0.61360027
74MP0004134_abnormal_chest_morphology0.60226586
75MP0000762_abnormal_tongue_morphology0.58083142
76MP0008872_abnormal_physiological_respon0.56057468
77MP0000678_abnormal_parathyroid_gland0.55801046
78MP0003385_abnormal_body_wall0.53648174
79MP0004043_abnormal_pH_regulation0.53205938
80MP0005165_increased_susceptibility_to0.52467502
81MP0009250_abnormal_appendicular_skeleto0.52374954
82MP0002877_abnormal_melanocyte_morpholog0.52161516
83MP0002139_abnormal_hepatobiliary_system0.51577627
84MP0001958_emphysema0.50525421
85MP0003566_abnormal_cell_adhesion0.50209647
86MP0000579_abnormal_nail_morphology0.49199572
87MP0003763_abnormal_thymus_physiology0.48538625
88MP0005023_abnormal_wound_healing0.48024815
89MP0003252_abnormal_bile_duct0.47953612
90MP0002734_abnormal_mechanical_nocicepti0.47666356
91MP0001486_abnormal_startle_reflex0.46859254
92MP0000230_abnormal_systemic_arterial0.46479258
93MP0002128_abnormal_blood_circulation0.45476339
94MP0008569_lethality_at_weaning0.45227487
95MP0002896_abnormal_bone_mineralization0.44918580
96MP0005623_abnormal_meninges_morphology0.44606252
97MP0002078_abnormal_glucose_homeostasis0.43717634
98MP0003656_abnormal_erythrocyte_physiolo0.43547777
99MP0002909_abnormal_adrenal_gland0.43390958
100MP0001270_distended_abdomen0.43039121
101MP0003279_aneurysm0.42967607
102MP0005503_abnormal_tendon_morphology0.42959043
103MP0000767_abnormal_smooth_muscle0.42874230
104MP0000372_irregular_coat_pigmentation0.41402580
105MP0005388_respiratory_system_phenotype0.38737897
106MP0002133_abnormal_respiratory_system0.38737897
107MP0005166_decreased_susceptibility_to0.38691092
108MP0003567_abnormal_fetal_cardiomyocyte0.38356029
109MP0002092_abnormal_eye_morphology0.38330633
110MP0003806_abnormal_nucleotide_metabolis0.37843749
111MP0005334_abnormal_fat_pad0.37467414
112MP0009384_cardiac_valve_regurgitation0.35964686
113MP0003283_abnormal_digestive_organ0.33423301
114MP0005360_urolithiasis0.33395093
115MP0008770_decreased_survivor_rate0.32697185
116MP0003948_abnormal_gas_homeostasis0.31420287
117MP0002114_abnormal_axial_skeleton0.30739481
118MP0005319_abnormal_enzyme/_coenzyme0.30522437
119MP0001346_abnormal_lacrimal_gland0.28485890
120MP0005164_abnormal_response_to0.27919832
121MP0009115_abnormal_fat_cell0.27904062
122MP0005452_abnormal_adipose_tissue0.27749691
123MP0002933_joint_inflammation0.27709043
124MP0001853_heart_inflammation0.25065031
125MP0003959_abnormal_lean_body0.25017492
126MP0001879_abnormal_lymphatic_vessel0.24803984
127MP0002060_abnormal_skin_morphology0.24318934
128MP0005535_abnormal_body_temperature0.23979062
129MP0002796_impaired_skin_barrier0.23382497
130MP0003011_delayed_dark_adaptation0.23349847
131MP0000685_abnormal_immune_system0.23119945
132MP0002095_abnormal_skin_pigmentation0.23038847
133MP0010368_abnormal_lymphatic_system0.22879318
134MP0004272_abnormal_basement_membrane0.20741817
135MP0005584_abnormal_enzyme/coenzyme_acti0.20144205
136MP0005451_abnormal_body_composition0.20140805
137MP0002089_abnormal_postnatal_growth/wei0.19127014
138MP0001614_abnormal_blood_vessel0.19018063
139MP0002925_abnormal_cardiovascular_devel0.18764068
140MP0009672_abnormal_birth_weight0.18674576

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.60565505
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.17807350
3Nemaline bodies (HP:0003798)8.74053362
4Type 1 muscle fiber predominance (HP:0003803)7.84847267
5Exercise-induced myalgia (HP:0003738)7.57707500
6Exercise-induced muscle cramps (HP:0003710)6.81742235
7Distal arthrogryposis (HP:0005684)6.26593006
8Muscle hypertrophy of the lower extremities (HP:0008968)6.18886084
9Calf muscle hypertrophy (HP:0008981)5.96649907
10Myopathic facies (HP:0002058)5.84795742
11Muscle fiber splitting (HP:0003555)5.70882368
12Hyporeflexia of lower limbs (HP:0002600)5.26573424
13Round ear (HP:0100830)5.25759709
14Ulnar deviation of the wrist (HP:0003049)4.98319779
15EMG: myopathic abnormalities (HP:0003458)4.85650273
16Difficulty running (HP:0009046)4.82354107
17Abnormality of the calf musculature (HP:0001430)4.72249598
18Myoglobinuria (HP:0002913)4.55544086
19Increased connective tissue (HP:0009025)4.55159336
20Arterial tortuosity (HP:0005116)4.23574612
21Abnormality of skeletal muscle fiber size (HP:0012084)4.23456964
22Renal cortical cysts (HP:0000803)4.18906224
23Calcaneovalgus deformity (HP:0001848)4.18697336
24Hypoplasia of the thymus (HP:0000778)4.16099280
25Sudden death (HP:0001699)4.12580090
26Deformed tarsal bones (HP:0008119)3.82040391
27Absent phalangeal crease (HP:0006109)3.80910268
28Muscle stiffness (HP:0003552)3.80021150
29Myotonia (HP:0002486)3.79281939
30Turricephaly (HP:0000262)3.76448050
31Increased variability in muscle fiber diameter (HP:0003557)3.76224879
32Neck muscle weakness (HP:0000467)3.76006315
33Vascular tortuosity (HP:0004948)3.74082222
34Rhabdomyolysis (HP:0003201)3.66427984
35Abnormality of the left ventricular outflow tract (HP:0011103)3.58778058
36Subaortic stenosis (HP:0001682)3.58778058
37Difficulty climbing stairs (HP:0003551)3.50448731
38Malignant hyperthermia (HP:0002047)3.41877096
39Asymmetric septal hypertrophy (HP:0001670)3.35388484
40Frequent falls (HP:0002359)3.27324467
41Ventricular tachycardia (HP:0004756)3.16395758
42Abnormal finger flexion creases (HP:0006143)3.11843582
43Increased serum pyruvate (HP:0003542)3.08362116
44Rimmed vacuoles (HP:0003805)3.05533934
45Poor suck (HP:0002033)3.04549063
46Mildly elevated creatine phosphokinase (HP:0008180)3.01169437
47Muscle fiber atrophy (HP:0100295)2.97949698
48Areflexia of lower limbs (HP:0002522)2.97906610
49Fetal akinesia sequence (HP:0001989)2.90183821
50Fatigable weakness (HP:0003473)2.90156647
51Abnormality of the neuromuscular junction (HP:0003398)2.90156647
52Distal lower limb muscle weakness (HP:0009053)2.77996877
53Skin nodule (HP:0200036)2.77788468
54Slender build (HP:0001533)2.76102914
55Abnormality of glycolysis (HP:0004366)2.69227033
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.66584237
57Gowers sign (HP:0003391)2.65879643
58Aortic aneurysm (HP:0004942)2.64805541
59Weak cry (HP:0001612)2.62992717
60Protrusio acetabuli (HP:0003179)2.60899546
61Generalized muscle weakness (HP:0003324)2.60841482
62Bulbar palsy (HP:0001283)2.60069378
63Abnormality of the calcaneus (HP:0008364)2.59171974
64Abnormal cartilage morphology (HP:0002763)2.58868626
65Metatarsus adductus (HP:0001840)2.57575358
66Spinal rigidity (HP:0003306)2.57330771
67Hypoplastic ischia (HP:0003175)2.56570548
68Scapular winging (HP:0003691)2.55357707
69Limb-girdle muscle atrophy (HP:0003797)2.55155600
70Lipoatrophy (HP:0100578)2.54400251
71Right ventricular cardiomyopathy (HP:0011663)2.53886835
72EMG: neuropathic changes (HP:0003445)2.52067042
73Brushfield spots (HP:0001088)2.47871100
74Distal lower limb amyotrophy (HP:0008944)2.47196294
75Palpebral edema (HP:0100540)2.45054806
76Facial diplegia (HP:0001349)2.44520145
77Hip contracture (HP:0003273)2.39482741
78Dilated cardiomyopathy (HP:0001644)2.37615537
79Muscular dystrophy (HP:0003560)2.35277287
80Pelvic girdle muscle weakness (HP:0003749)2.33337053
81Shoulder girdle muscle weakness (HP:0003547)2.33287983
82Spondylolisthesis (HP:0003302)2.31742275
83Abnormality of the musculature of the pelvis (HP:0001469)2.30073248
84Abnormality of the hip-girdle musculature (HP:0001445)2.30073248
85Abnormal EKG (HP:0003115)2.29035099
86Atrial fibrillation (HP:0005110)2.25352252
87Abnormality of the ischium (HP:0003174)2.22067353
88Abnormality of the renal cortex (HP:0011035)2.19543351
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.18963544
90Proximal amyotrophy (HP:0007126)2.17821093
91Progressive muscle weakness (HP:0003323)2.15898854
92Waddling gait (HP:0002515)2.13877505
93Hyperkalemia (HP:0002153)2.11693808
94Abnormality of placental membranes (HP:0011409)2.11263423
95Amniotic constriction ring (HP:0009775)2.11263423
96Primary atrial arrhythmia (HP:0001692)2.08833199
97Bundle branch block (HP:0011710)2.08202401
98Limb-girdle muscle weakness (HP:0003325)2.07023715
99Abnormality of the shoulder girdle musculature (HP:0001435)2.07017910
100Supraventricular tachycardia (HP:0004755)2.00676918
101Prolonged QT interval (HP:0001657)1.97649383
102Aortic dissection (HP:0002647)1.97468119
103Supraventricular arrhythmia (HP:0005115)1.96503195
104Aortic regurgitation (HP:0001659)1.96020801
105Lower limb amyotrophy (HP:0007210)1.90579036
106Ventricular arrhythmia (HP:0004308)1.89779710
107Increased serum ferritin (HP:0003281)1.87461561
108Palpitations (HP:0001962)1.86400541
109Respiratory insufficiency due to muscle weakness (HP:0002747)1.82172816
110Popliteal pterygium (HP:0009756)1.78522778
111Left ventricular hypertrophy (HP:0001712)1.78174159
112Lower limb muscle weakness (HP:0007340)1.78061492
113Limited hip movement (HP:0008800)1.74942154
114Foot dorsiflexor weakness (HP:0009027)1.74905228
115Heart block (HP:0012722)1.73531411
116Abnormal atrioventricular conduction (HP:0005150)1.73527464
117Cubitus valgus (HP:0002967)1.73066417
118Type 2 muscle fiber atrophy (HP:0003554)1.72435744
119Abnormality of the foot musculature (HP:0001436)1.72159126
120Death in childhood (HP:0003819)1.71124171
121Nonprogressive disorder (HP:0003680)1.70895053
122Childhood onset (HP:0011463)1.69824916
123Ulnar deviation of finger (HP:0009465)1.69241455
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.65603553
125Paralysis (HP:0003470)1.64115080
126Syncope (HP:0001279)1.62634818
127Easy fatigability (HP:0003388)1.62161023
128Steppage gait (HP:0003376)1.61728612
129Increased corneal curvature (HP:0100692)1.61504836
130Keratoconus (HP:0000563)1.61504836
131Testicular atrophy (HP:0000029)1.60750098
132Abnormality of iron homeostasis (HP:0011031)1.60680210
133Long clavicles (HP:0000890)1.59457357
134Achilles tendon contracture (HP:0001771)1.59180576
135Rocker bottom foot (HP:0001838)1.56746624
136Hepatosplenomegaly (HP:0001433)1.52640683
137Difficulty walking (HP:0002355)1.50307456
138Clitoromegaly (HP:0000057)1.49841436
139Ankle clonus (HP:0011448)1.46025519
140Abnormal biliary tract morphology (HP:0012440)1.40121763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.88077045
2MAPKAPK57.59005567
3TTN6.27340128
4CDK85.44127134
5CCNB14.72511352
6PHKG14.48792271
7PHKG24.48792271
8PIK3CG3.73977161
9NME13.47246082
10SCYL23.15091107
11TRIB32.40230015
12DMPK2.38898487
13MUSK2.27142192
14MELK2.25403939
15PDK32.23580338
16PDK42.23580338
17MAP2K32.14725877
18NEK12.00331096
19MAP3K71.90864280
20CDK91.84048386
21PINK11.82245621
22BCKDK1.55093240
23PIK3CA1.51493822
24MAPK121.50412107
25PDK21.48466669
26PKN21.43472498
27MAP3K31.25960873
28CDK41.19860239
29MAPKAPK31.19022811
30MARK21.16739325
31MAP2K60.99020703
32STK240.98389766
33EPHB10.93703904
34LMTK20.86970837
35SMG10.86051850
36MAP2K40.82438874
37TRPM70.81911996
38PAK20.78029296
39MAP3K100.77705461
40FLT30.77338569
41PRKAA20.76733831
42TIE10.76166531
43PRKAA10.75900046
44CSNK1D0.72880116
45RIPK10.70220596
46TNK20.66944769
47ROCK10.65505686
48TGFBR20.64631675
49ILK0.62787742
50FGFR10.61839467
51AKT20.61269826
52CAMK2B0.60062724
53PTK20.60024352
54TAOK20.59676308
55ZAK0.58242267
56MAPK110.57732999
57PTK60.55994883
58EIF2AK30.55835611
59NEK90.54838238
60PKN10.53731991
61PRKD10.52859502
62CAMK2G0.52042766
63MYLK0.50823752
64TAOK10.49916164
65FER0.49098606
66MAP3K110.47803318
67NTRK20.47626320
68CAMK2D0.45259011
69EEF2K0.45034588
70MAP3K50.44994217
71MOS0.42444568
72ERBB40.41019249
73EPHA30.40535466
74DDR20.39664444
75ROCK20.39091091
76MARK10.37286165
77SIK10.35967756
78PAK60.34836962
79GRK50.34543885
80PRKACB0.34147335
81GRK70.32967732
82ABL10.32894307
83MST1R0.32092627
84PDPK10.31966192
85PRKCG0.31715345
86PRKG10.31691062
87LIMK10.31247138
88MAP3K10.29635030
89MAP2K10.28990618
90SGK10.28758944
91ERBB30.27697839
92PRKACA0.25684320
93DAPK20.25601690
94STK40.25435639
95ICK0.24989468
96INSRR0.23259272
97PDGFRA0.23084733
98ERN10.22558226
99CLK10.22452030
100RPS6KA30.22283889
101VRK10.22138341
102STK380.21978215
103TYK20.21224937
104DAPK30.20947779
105FGFR40.20805866
106LRRK20.20420955
107PIM20.20202619
108LATS10.20018219
109STK38L0.19895491
110PDK10.19747803
111AURKA0.19653289
112JAK10.19509626
113NEK60.19142910
114BMX0.18764238
115PAK30.18623361
116STK30.17228383
117PTK2B0.16555593
118DAPK10.16477565
119ARAF0.16469582
120CAMK2A0.16215281
121TAF10.16170877
122CDK11A0.15220113
123PRKACG0.15005710
124TBK10.14781282
125MTOR0.14650069
126VRK20.14470112
127MAP3K40.14181124
128MAPK70.14039738
129MAP3K60.13731068
130MAPK40.13625666
131CDK60.12733665
132CDC42BPA0.12674955
133JAK20.12416761
134LATS20.12199808
135CSNK1G20.11917915
136KSR20.11159791
137GSK3A0.10982941
138RPS6KA10.10905692
139CSNK2A20.10857462
140PRKCA0.10736447
141IGF1R0.10637562
142MAPKAPK20.09755305
143SGK30.08568713
144CDK150.08161360
145PRKG20.08062195
146MAPK80.07404951
147PRKCE0.07230520
148MAPK140.06524518
149CDK180.04959388
150PLK20.04369240
151PRKDC0.04337182
152ZAP700.03994117
153PRKCB0.03853233
154CDK140.02477804
155CAMK40.01534089
156AURKB0.01470814
157EGFR0.01071034
158SGK20.00892599

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.58923486
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.51145044
3Dilated cardiomyopathy_Homo sapiens_hsa054144.14475358
4Cardiac muscle contraction_Homo sapiens_hsa042604.05002582
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.73594716
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051003.71548555
7Histidine metabolism_Homo sapiens_hsa003403.67974187
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35785182
9Selenocompound metabolism_Homo sapiens_hsa004503.10164516
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94544328
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94281247
12Propanoate metabolism_Homo sapiens_hsa006402.21359165
13Starch and sucrose metabolism_Homo sapiens_hsa005002.13015138
14Carbon metabolism_Homo sapiens_hsa012002.09414312
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91922131
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89001040
17ABC transporters_Homo sapiens_hsa020101.85339138
18Parkinsons disease_Homo sapiens_hsa050121.83449402
19Viral myocarditis_Homo sapiens_hsa054161.74888057
20Oxytocin signaling pathway_Homo sapiens_hsa049211.73817589
21Fatty acid degradation_Homo sapiens_hsa000711.69184910
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65712388
23Insulin signaling pathway_Homo sapiens_hsa049101.61796639
24Insulin resistance_Homo sapiens_hsa049311.61767683
25Glucagon signaling pathway_Homo sapiens_hsa049221.60462233
26Alzheimers disease_Homo sapiens_hsa050101.60396173
27Oxidative phosphorylation_Homo sapiens_hsa001901.58579446
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44784871
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40318075
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.38357757
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.36687994
32Colorectal cancer_Homo sapiens_hsa052101.36150109
33Calcium signaling pathway_Homo sapiens_hsa040201.32985793
34Glycerolipid metabolism_Homo sapiens_hsa005611.32278917
35Circadian rhythm_Homo sapiens_hsa047101.29395498
36Pyruvate metabolism_Homo sapiens_hsa006201.29141406
37Focal adhesion_Homo sapiens_hsa045101.26973826
38Galactose metabolism_Homo sapiens_hsa000521.25660944
39Biosynthesis of amino acids_Homo sapiens_hsa012301.24959488
40AMPK signaling pathway_Homo sapiens_hsa041521.21087250
41Fatty acid metabolism_Homo sapiens_hsa012121.18929956
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18193706
43Tight junction_Homo sapiens_hsa045301.14061095
44Fructose and mannose metabolism_Homo sapiens_hsa000511.13773435
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.03731108
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99816345
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.97774325
48Caffeine metabolism_Homo sapiens_hsa002320.96027150
49HIF-1 signaling pathway_Homo sapiens_hsa040660.94012135
50Peroxisome_Homo sapiens_hsa041460.93099549
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.90587672
52ECM-receptor interaction_Homo sapiens_hsa045120.90418947
53Endocytosis_Homo sapiens_hsa041440.88607888
54GnRH signaling pathway_Homo sapiens_hsa049120.83084662
55Huntingtons disease_Homo sapiens_hsa050160.81493166
56Renin secretion_Homo sapiens_hsa049240.79912875
57Arginine and proline metabolism_Homo sapiens_hsa003300.77303175
58Gastric acid secretion_Homo sapiens_hsa049710.75648092
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73919053
60VEGF signaling pathway_Homo sapiens_hsa043700.68688964
61Pentose phosphate pathway_Homo sapiens_hsa000300.68435914
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65447106
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64120403
64Pancreatic cancer_Homo sapiens_hsa052120.62689515
65MAPK signaling pathway_Homo sapiens_hsa040100.62575142
66Proteoglycans in cancer_Homo sapiens_hsa052050.62094451
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61975258
68Amoebiasis_Homo sapiens_hsa051460.61711466
69Insulin secretion_Homo sapiens_hsa049110.61564485
70PPAR signaling pathway_Homo sapiens_hsa033200.60259267
71Arginine biosynthesis_Homo sapiens_hsa002200.59061728
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56532661
73Type II diabetes mellitus_Homo sapiens_hsa049300.56350902
74Adherens junction_Homo sapiens_hsa045200.55122575
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54825850
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52644039
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51899716
78mTOR signaling pathway_Homo sapiens_hsa041500.51038753
79Folate biosynthesis_Homo sapiens_hsa007900.50672247
80FoxO signaling pathway_Homo sapiens_hsa040680.49792935
81Fatty acid biosynthesis_Homo sapiens_hsa000610.49165848
82Renal cell carcinoma_Homo sapiens_hsa052110.48689472
83Wnt signaling pathway_Homo sapiens_hsa043100.48669704
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.48609527
85Platelet activation_Homo sapiens_hsa046110.45703965
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44931634
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43712269
88Serotonergic synapse_Homo sapiens_hsa047260.43111524
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41666390
90TGF-beta signaling pathway_Homo sapiens_hsa043500.40817706
91Butanoate metabolism_Homo sapiens_hsa006500.40595503
92Phenylalanine metabolism_Homo sapiens_hsa003600.39252369
93cAMP signaling pathway_Homo sapiens_hsa040240.39081995
94Cholinergic synapse_Homo sapiens_hsa047250.36588756
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34708170
96Hippo signaling pathway_Homo sapiens_hsa043900.34461513
97Dorso-ventral axis formation_Homo sapiens_hsa043200.34103186
98Pertussis_Homo sapiens_hsa051330.33546547
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33048071
100Circadian entrainment_Homo sapiens_hsa047130.32251983
101Lysine degradation_Homo sapiens_hsa003100.26105045
102Regulation of autophagy_Homo sapiens_hsa041400.25706230
103Toxoplasmosis_Homo sapiens_hsa051450.25224621
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24628969
105Protein digestion and absorption_Homo sapiens_hsa049740.23332129
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22125475
107beta-Alanine metabolism_Homo sapiens_hsa004100.21603923
108Osteoclast differentiation_Homo sapiens_hsa043800.21155938
109Gap junction_Homo sapiens_hsa045400.20868177
110Fatty acid elongation_Homo sapiens_hsa000620.19358387
111Protein export_Homo sapiens_hsa030600.18762982
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16812846
113Salivary secretion_Homo sapiens_hsa049700.16696077
114Pancreatic secretion_Homo sapiens_hsa049720.16551502
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16344752
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15996541
117Complement and coagulation cascades_Homo sapiens_hsa046100.15981945
118Salmonella infection_Homo sapiens_hsa051320.15943445
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.15883637
120Acute myeloid leukemia_Homo sapiens_hsa052210.15764624
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15185708
122Tryptophan metabolism_Homo sapiens_hsa003800.14743902
123p53 signaling pathway_Homo sapiens_hsa041150.14741846
124Melanogenesis_Homo sapiens_hsa049160.14614433
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14581880
126Legionellosis_Homo sapiens_hsa051340.13858474
127Olfactory transduction_Homo sapiens_hsa047400.12700200
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12117013
129Apoptosis_Homo sapiens_hsa042100.11259648
130Prolactin signaling pathway_Homo sapiens_hsa049170.10485292
131Retinol metabolism_Homo sapiens_hsa008300.10015383
132Linoleic acid metabolism_Homo sapiens_hsa005910.09663564
133GABAergic synapse_Homo sapiens_hsa047270.09192368
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09094714
135Spliceosome_Homo sapiens_hsa030400.08512061
136Amphetamine addiction_Homo sapiens_hsa050310.07357006
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04105829

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