INTS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.59736310
2nuclear pore organization (GO:0006999)5.52557356
3synapsis (GO:0007129)4.91832391
4piRNA metabolic process (GO:0034587)4.76060690
5mitotic sister chromatid cohesion (GO:0007064)4.72356263
6pore complex assembly (GO:0046931)4.49927630
7kinetochore organization (GO:0051383)4.40439193
8regulation of DNA methylation (GO:0044030)4.30809515
9gene silencing by RNA (GO:0031047)4.10484435
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94517336
11mitotic nuclear envelope disassembly (GO:0007077)3.92693150
12regulation of DNA endoreduplication (GO:0032875)3.87346036
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82373105
14somatic hypermutation of immunoglobulin genes (GO:0016446)3.82373105
15positive regulation of histone H3-K4 methylation (GO:0051571)3.82137725
16meiotic chromosome segregation (GO:0045132)3.80171080
17DNA methylation involved in gamete generation (GO:0043046)3.78565153
18mitotic metaphase plate congression (GO:0007080)3.76844712
19translesion synthesis (GO:0019985)3.76207555
20kinetochore assembly (GO:0051382)3.74314797
21protein localization to kinetochore (GO:0034501)3.73557658
22membrane disassembly (GO:0030397)3.65614386
23nuclear envelope disassembly (GO:0051081)3.65614386
24regulation of meiosis I (GO:0060631)3.64286135
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.62960444
26CENP-A containing nucleosome assembly (GO:0034080)3.61271884
27chromatin remodeling at centromere (GO:0031055)3.61247155
28metaphase plate congression (GO:0051310)3.60667815
29meiotic cell cycle (GO:0051321)3.59058683
30DNA replication-independent nucleosome organization (GO:0034724)3.56951079
31DNA replication-independent nucleosome assembly (GO:0006336)3.56951079
32DNA unwinding involved in DNA replication (GO:0006268)3.55544480
33centriole replication (GO:0007099)3.53153236
34mitotic chromosome condensation (GO:0007076)3.50147016
35sister chromatid segregation (GO:0000819)3.49938092
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.49206724
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49206724
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49206724
39regulation of RNA export from nucleus (GO:0046831)3.47595950
40DNA synthesis involved in DNA repair (GO:0000731)3.44947330
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40608815
42regulation of mitotic spindle checkpoint (GO:1903504)3.40608815
43paraxial mesoderm development (GO:0048339)3.39676259
44protein localization to chromosome, centromeric region (GO:0071459)3.36545492
45DNA replication initiation (GO:0006270)3.35019164
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.33530861
47regulation of centriole replication (GO:0046599)3.29603185
48DNA replication-dependent nucleosome organization (GO:0034723)3.26106917
49DNA replication-dependent nucleosome assembly (GO:0006335)3.26106917
50non-recombinational repair (GO:0000726)3.23916776
51double-strand break repair via nonhomologous end joining (GO:0006303)3.23916776
52postreplication repair (GO:0006301)3.23749066
53regulation of sister chromatid cohesion (GO:0007063)3.23286721
54mitotic sister chromatid segregation (GO:0000070)3.22291343
55regulation of histone H3-K9 methylation (GO:0051570)3.21961356
56attachment of spindle microtubules to kinetochore (GO:0008608)3.19480141
57nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.19075752
58chromosome organization involved in meiosis (GO:0070192)3.18734192
59pre-miRNA processing (GO:0031054)3.17011918
60monoubiquitinated protein deubiquitination (GO:0035520)3.16627422
61DNA replication checkpoint (GO:0000076)3.15669779
62establishment of chromosome localization (GO:0051303)3.14375824
63DNA topological change (GO:0006265)3.14175700
64histone exchange (GO:0043486)3.13231597
65positive regulation of chromosome segregation (GO:0051984)3.12902199
66positive regulation of cell cycle checkpoint (GO:1901978)3.12321682
67DNA geometric change (GO:0032392)3.11171998
68replication fork processing (GO:0031297)3.10656409
69resolution of meiotic recombination intermediates (GO:0000712)3.09973633
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09713778
71DNA duplex unwinding (GO:0032508)3.09187180
72chromatin assembly or disassembly (GO:0006333)3.08552714
73regulation of centrosome cycle (GO:0046605)3.07132807
74male meiosis (GO:0007140)3.06380382
75ATP-dependent chromatin remodeling (GO:0043044)3.05796100
76negative regulation of histone methylation (GO:0031061)3.05153608
77regulation of spindle organization (GO:0090224)3.04953231
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03834135
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03445870
80reciprocal meiotic recombination (GO:0007131)3.02497241
81reciprocal DNA recombination (GO:0035825)3.02497241
82regulation of spindle checkpoint (GO:0090231)3.02100223
83DNA double-strand break processing (GO:0000729)3.01963932
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.00972440
85sister chromatid cohesion (GO:0007062)2.99872634
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98982383
87positive regulation of histone methylation (GO:0031062)2.97874354
88protein K6-linked ubiquitination (GO:0085020)2.97346352
89spindle checkpoint (GO:0031577)2.97340460
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97178182
91mitotic recombination (GO:0006312)2.95369575
92histone H3-K9 methylation (GO:0051567)2.92429247
93DNA strand elongation involved in DNA replication (GO:0006271)2.91534410
94regulation of helicase activity (GO:0051095)2.90261665
95negative regulation of DNA repair (GO:0045738)2.88340910
96regulation of centrosome duplication (GO:0010824)2.87208772
97spindle assembly checkpoint (GO:0071173)2.86687023
98regulation of double-strand break repair (GO:2000779)2.86474721
99protein localization to chromosome (GO:0034502)2.85128875
100regulation of mitotic sister chromatid separation (GO:0010965)2.84559176
101regulation of mitotic sister chromatid segregation (GO:0033047)2.84559176
102regulation of sister chromatid segregation (GO:0033045)2.84559176
103regulation of chromosome segregation (GO:0051983)2.84300294
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84267259
105IMP biosynthetic process (GO:0006188)2.83062346
106telomere maintenance via semi-conservative replication (GO:0032201)2.82789834
107DNA strand elongation (GO:0022616)2.82128593
108telomere maintenance via recombination (GO:0000722)2.81853517
109mitotic spindle checkpoint (GO:0071174)2.80456833
110chromosome segregation (GO:0007059)2.79983582
111negative regulation of chromosome segregation (GO:0051985)2.79931647
112regulation of mitotic spindle organization (GO:0060236)2.79710057
113mitotic spindle assembly checkpoint (GO:0007094)2.77733153
114mRNA transport (GO:0051028)2.77374344
115regulation of nucleobase-containing compound transport (GO:0032239)2.76931832
116nuclear envelope organization (GO:0006998)2.76801918
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.75749106
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75749106
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75749106
120negative regulation of sister chromatid segregation (GO:0033046)2.75749106
121intra-S DNA damage checkpoint (GO:0031573)2.73970327
122regulation of gene silencing by RNA (GO:0060966)2.69927398
123regulation of posttranscriptional gene silencing (GO:0060147)2.69927398
124regulation of gene silencing by miRNA (GO:0060964)2.69927398
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67961551
126negative regulation of RNA splicing (GO:0033119)2.67953270
127DNA conformation change (GO:0071103)2.67319694
128chromatin assembly (GO:0031497)2.66596927
129mRNA export from nucleus (GO:0006406)2.66422285
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66163831
131folic acid-containing compound biosynthetic process (GO:0009396)2.66073387
132regulation of DNA-dependent DNA replication (GO:0090329)2.66052960
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.65463052
134heterochromatin organization (GO:0070828)2.65110116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.48571520
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.75322334
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67379903
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.64793318
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.40349583
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.37096444
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.16306617
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.98077396
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80086459
10AR_21909140_ChIP-Seq_LNCAP_Human2.63961406
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.63318498
12IGF1R_20145208_ChIP-Seq_DFB_Human2.35842761
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25602536
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16141056
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07763489
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06235838
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03985433
18E2F7_22180533_ChIP-Seq_HELA_Human11.2112466
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96334833
20IRF1_19129219_ChIP-ChIP_H3396_Human1.94645534
21ELK1_19687146_ChIP-ChIP_HELA_Human1.91402134
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89503114
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81075661
24ZNF274_21170338_ChIP-Seq_K562_Hela1.76405386
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75519444
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74794588
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72413643
28* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68342451
29GATA1_22025678_ChIP-Seq_K562_Human1.67035216
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64959553
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60694772
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60214730
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55752999
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.52636043
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51771358
36MYC_22102868_ChIP-Seq_BL_Human1.51530901
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50200440
38TAF15_26573619_Chip-Seq_HEK293_Human1.49385987
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46703851
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45877584
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45877584
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45877584
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44307260
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44050558
45* VDR_23849224_ChIP-Seq_CD4+_Human1.43818326
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43685054
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41717498
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38718434
49VDR_22108803_ChIP-Seq_LS180_Human1.37296633
50CIITA_25753668_ChIP-Seq_RAJI_Human1.33327369
51EZH2_22144423_ChIP-Seq_EOC_Human1.32834566
52KDM5A_27292631_Chip-Seq_BREAST_Human1.31859292
53XRN2_22483619_ChIP-Seq_HELA_Human1.29328491
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27923305
55FOXP3_21729870_ChIP-Seq_TREG_Human1.27056085
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26730461
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.25952752
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22905821
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21763361
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21618625
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20972049
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20658764
63TTF2_22483619_ChIP-Seq_HELA_Human1.20288502
64ER_23166858_ChIP-Seq_MCF-7_Human1.16703062
65* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16521930
66DCP1A_22483619_ChIP-Seq_HELA_Human1.14886035
67EWS_26573619_Chip-Seq_HEK293_Human1.13484177
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13006175
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11369867
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10464656
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10191163
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09600208
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09498616
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08385217
75* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07437582
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05562659
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05104145
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04903284
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.03314054
80TFEB_21752829_ChIP-Seq_HELA_Human1.02650539
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02589260
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.01773017
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01507001
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01448882
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98274060
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97205071
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95743267
88BRD4_25478319_ChIP-Seq_HGPS_Human0.95509163
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94180287
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.94039511
91GABP_19822575_ChIP-Seq_HepG2_Human0.93652934
92STAT3_23295773_ChIP-Seq_U87_Human0.93062735
93TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92390779
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92228901
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91888786
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91060368
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91012674
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91010406
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90412500
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90269642
101P300_19829295_ChIP-Seq_ESCs_Human0.89905697
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.89438037
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87677724
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.86573960
105ETS1_20019798_ChIP-Seq_JURKAT_Human0.86404680
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86280792
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86171334
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85578692
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84778340
110TCF4_23295773_ChIP-Seq_U87_Human0.84731859
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84435164
112CHD1_26751641_Chip-Seq_LNCaP_Human0.84272723
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83685993
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83447779
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82737296
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.80709504
117MYB_26560356_Chip-Seq_TH1_Human0.80515459
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80443418
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79643580
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78314524
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77785492
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77541364
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75889540
124MYC_18940864_ChIP-ChIP_HL60_Human0.75255992
125FUS_26573619_Chip-Seq_HEK293_Human0.75252821
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74647263
127MYB_26560356_Chip-Seq_TH2_Human0.74495727
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.74412523
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74189497
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73679835
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73671080
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73408818
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73310060
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73086117
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72928189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.69198005
2MP0008057_abnormal_DNA_replication3.59729605
3MP0003111_abnormal_nucleus_morphology3.22718501
4MP0003718_maternal_effect3.19290564
5MP0003693_abnormal_embryo_hatching3.05609004
6MP0003077_abnormal_cell_cycle2.86014065
7MP0004957_abnormal_blastocyst_morpholog2.58215325
8MP0008058_abnormal_DNA_repair2.56232427
9MP0008877_abnormal_DNA_methylation2.44328728
10MP0010352_gastrointestinal_tract_polyps2.31967957
11MP0008007_abnormal_cellular_replicative2.25251556
12MP0010030_abnormal_orbit_morphology2.04069050
13MP0005076_abnormal_cell_differentiation2.02767680
14MP0003121_genomic_imprinting1.96951282
15MP0003123_paternal_imprinting1.96257052
16MP0010307_abnormal_tumor_latency1.91570285
17MP0002396_abnormal_hematopoietic_system1.89242838
18MP0009053_abnormal_anal_canal1.88652548
19MP0000569_abnormal_digit_pigmentation1.85179085
20MP0009697_abnormal_copulation1.84252114
21MP0008789_abnormal_olfactory_epithelium1.83315729
22MP0000350_abnormal_cell_proliferation1.81906529
23MP0005451_abnormal_body_composition1.76042681
24MP0003890_abnormal_embryonic-extraembry1.73785576
25MP0008932_abnormal_embryonic_tissue1.72331734
26MP0001929_abnormal_gametogenesis1.65025459
27MP0005380_embryogenesis_phenotype1.61111050
28MP0001672_abnormal_embryogenesis/_devel1.61111050
29MP0004197_abnormal_fetal_growth/weight/1.59132676
30MP0008995_early_reproductive_senescence1.58684495
31MP0010678_abnormal_skin_adnexa1.56961870
32MP0002009_preneoplasia1.54966241
33MP0005394_taste/olfaction_phenotype1.53886542
34MP0005499_abnormal_olfactory_system1.53886542
35MP0003941_abnormal_skin_development1.48969522
36MP0003984_embryonic_growth_retardation1.48476517
37MP0003567_abnormal_fetal_cardiomyocyte1.48327741
38MP0001293_anophthalmia1.47948810
39MP0002088_abnormal_embryonic_growth/wei1.47267627
40MP0003937_abnormal_limbs/digits/tail_de1.46992263
41MP0001730_embryonic_growth_arrest1.46834741
42MP0000537_abnormal_urethra_morphology1.46791294
43MP0004808_abnormal_hematopoietic_stem1.46088620
44MP0003221_abnormal_cardiomyocyte_apopto1.45772042
45MP0002086_abnormal_extraembryonic_tissu1.43032002
46MP0003787_abnormal_imprinting1.42452420
47MP0000490_abnormal_crypts_of1.42327923
48MP0000566_synostosis1.41863087
49MP0002085_abnormal_embryonic_tissue1.41133221
50MP0002084_abnormal_developmental_patter1.40295543
51MP0000427_abnormal_hair_cycle1.39861941
52MP0002234_abnormal_pharynx_morphology1.38257548
53MP0001697_abnormal_embryo_size1.36064039
54MP0006292_abnormal_olfactory_placode1.33447242
55MP0003786_premature_aging1.32925072
56MP0000516_abnormal_urinary_system1.31081872
57MP0005367_renal/urinary_system_phenotyp1.31081872
58MP0006072_abnormal_retinal_apoptosis1.24690204
59MP0005248_abnormal_Harderian_gland1.24645566
60MP0009703_decreased_birth_body1.22486062
61MP0003705_abnormal_hypodermis_morpholog1.18063071
62MP0000432_abnormal_head_morphology1.13517494
63MP0003943_abnormal_hepatobiliary_system1.11755769
64MP0010234_abnormal_vibrissa_follicle1.10666226
65MP0000428_abnormal_craniofacial_morphol1.10254676
66MP0003698_abnormal_male_reproductive1.09909999
67MP0003699_abnormal_female_reproductive1.09795120
68MP0003385_abnormal_body_wall1.08929583
69MP0002080_prenatal_lethality1.08285268
70MP0009672_abnormal_birth_weight1.07975231
71MP0003755_abnormal_palate_morphology1.07261193
72MP0003119_abnormal_digestive_system1.06487381
73MP0004147_increased_porphyrin_level1.06041914
74MP0000631_abnormal_neuroendocrine_gland1.05763108
75MP0002006_tumorigenesis1.04983964
76MP0003935_abnormal_craniofacial_develop1.04272092
77MP0002210_abnormal_sex_determination1.02868043
78MP0002938_white_spotting1.02485981
79MP0002877_abnormal_melanocyte_morpholog1.00253579
80MP0005647_abnormal_sex_gland0.98979356
81MP0005395_other_phenotype0.98317522
82MP0003315_abnormal_perineum_morphology0.98164000
83MP0002111_abnormal_tail_morphology0.97785361
84MP0002092_abnormal_eye_morphology0.97746097
85MP0001286_abnormal_eye_development0.97713706
86MP0000703_abnormal_thymus_morphology0.95434614
87MP0006035_abnormal_mitochondrial_morpho0.93974351
88MP0002160_abnormal_reproductive_system0.92952319
89MP0002019_abnormal_tumor_incidence0.92392509
90MP0001915_intracranial_hemorrhage0.91026228
91MP0000313_abnormal_cell_death0.91022939
92MP0003136_yellow_coat_color0.90525518
93MP0004264_abnormal_extraembryonic_tissu0.89402617
94MP0001119_abnormal_female_reproductive0.88611488
95MP0002697_abnormal_eye_size0.88498506
96MP0002928_abnormal_bile_duct0.87921765
97MP0002166_altered_tumor_susceptibility0.87560030
98MP0009278_abnormal_bone_marrow0.87093167
99MP0002161_abnormal_fertility/fecundity0.87090242
100MP0005503_abnormal_tendon_morphology0.86854463
101MP0001145_abnormal_male_reproductive0.85403046
102MP0000733_abnormal_muscle_development0.85317945
103MP0000383_abnormal_hair_follicle0.84720702
104MP0000647_abnormal_sebaceous_gland0.83627957
105MP0009250_abnormal_appendicular_skeleto0.83193492
106MP0002233_abnormal_nose_morphology0.82816906
107MP0000358_abnormal_cell_content/0.82383111
108MP0003861_abnormal_nervous_system0.80797031
109MP0003763_abnormal_thymus_physiology0.80541434
110MP0000371_diluted_coat_color0.79962384
111MP0002075_abnormal_coat/hair_pigmentati0.78924030
112MP0001873_stomach_inflammation0.78211434
113MP0005389_reproductive_system_phenotype0.78147114
114MP0001186_pigmentation_phenotype0.78081283
115MP0002932_abnormal_joint_morphology0.78074643
116MP0002925_abnormal_cardiovascular_devel0.77658342
117MP0002751_abnormal_autonomic_nervous0.77360114
118MP0000653_abnormal_sex_gland0.76424839
119MP0002177_abnormal_outer_ear0.76423281
120MP0002116_abnormal_craniofacial_bone0.75890190
121MP0002109_abnormal_limb_morphology0.75373699
122MP0003942_abnormal_urinary_system0.75118287
123MP0000627_abnormal_mammary_gland0.74372632
124MP0006054_spinal_hemorrhage0.74133515
125MP0003122_maternal_imprinting0.73969586
126MP0003115_abnormal_respiratory_system0.72715352
127MP0002398_abnormal_bone_marrow0.72650704
128MP0003936_abnormal_reproductive_system0.71685368
129MP0000015_abnormal_ear_pigmentation0.69435896
130MP0005075_abnormal_melanosome_morpholog0.68777246
131MP0005391_vision/eye_phenotype0.66010489
132MP0003183_abnormal_peptide_metabolism0.65939045
133MP0002095_abnormal_skin_pigmentation0.62181732
134MP0001529_abnormal_vocalization0.61570852
135MP0005174_abnormal_tail_pigmentation0.58047244
136MP0000049_abnormal_middle_ear0.57763180
137MP0005253_abnormal_eye_physiology0.57105116

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.68306348
2Volvulus (HP:0002580)3.57798267
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49567307
4Short 4th metacarpal (HP:0010044)3.36950202
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.36950202
6Ectopic kidney (HP:0000086)3.14443562
711 pairs of ribs (HP:0000878)2.97471782
8Supernumerary spleens (HP:0009799)2.85247609
9Papillary thyroid carcinoma (HP:0002895)2.81769762
10Abnormality of chromosome stability (HP:0003220)2.76571401
11Abnormality of the fingertips (HP:0001211)2.76103848
12Birth length less than 3rd percentile (HP:0003561)2.68251698
13Meckel diverticulum (HP:0002245)2.53583203
14Colon cancer (HP:0003003)2.49545606
15Spinal cord lesions (HP:0100561)2.49185264
16Syringomyelia (HP:0003396)2.49185264
17Abnormality of the nasal septum (HP:0000419)2.43737693
18Fair hair (HP:0002286)2.43501582
19Increased nuchal translucency (HP:0010880)2.42713307
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.41989234
21Molar tooth sign on MRI (HP:0002419)2.41771212
22Abnormality of midbrain morphology (HP:0002418)2.41771212
23Abnormality of the ileum (HP:0001549)2.39041827
24Patellar aplasia (HP:0006443)2.37247975
25Medulloblastoma (HP:0002885)2.34842654
26Oligodactyly (hands) (HP:0001180)2.32596547
27Long eyelashes (HP:0000527)2.32201596
28Thyroid carcinoma (HP:0002890)2.32156329
29Abnormality of the labia minora (HP:0012880)2.31767802
30Abnormality of the 4th metacarpal (HP:0010012)2.30481518
31Deep philtrum (HP:0002002)2.29982399
32Capillary hemangiomas (HP:0005306)2.28650617
33Chronic hepatic failure (HP:0100626)2.27446736
34Pancreatic cysts (HP:0001737)2.25128748
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.24325580
36Impulsivity (HP:0100710)2.24216483
37Absent radius (HP:0003974)2.24002943
38Deviation of the thumb (HP:0009603)2.22947659
39Pancreatic fibrosis (HP:0100732)2.22272099
40Gonadotropin excess (HP:0000837)2.18386249
41Genetic anticipation (HP:0003743)2.17125489
42Aplasia/Hypoplasia of the patella (HP:0006498)2.17088047
43Abnormal number of incisors (HP:0011064)2.16095443
44Breast carcinoma (HP:0003002)2.15868055
45Trigonocephaly (HP:0000243)2.15260700
46Selective tooth agenesis (HP:0001592)2.15062542
47Abnormality of the preputium (HP:0100587)2.14370010
48Nephroblastoma (Wilms tumor) (HP:0002667)2.13805574
49Proximal placement of thumb (HP:0009623)2.12855943
50Supernumerary ribs (HP:0005815)2.12608372
51Short middle phalanx of the 5th finger (HP:0004220)2.11601711
52Rhabdomyosarcoma (HP:0002859)2.09899686
53Absent forearm bone (HP:0003953)2.08665689
54Aplasia involving forearm bones (HP:0009822)2.08665689
55Limb hypertonia (HP:0002509)2.08366959
56Astrocytoma (HP:0009592)2.06816408
57Abnormality of the astrocytes (HP:0100707)2.06816408
58Facial hemangioma (HP:0000329)2.05527560
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.04098911
60Broad distal phalanx of finger (HP:0009836)2.02153241
61Congenital primary aphakia (HP:0007707)2.01704950
62Missing ribs (HP:0000921)2.01460461
63Truncal obesity (HP:0001956)2.01335171
64Nephrogenic diabetes insipidus (HP:0009806)2.00970946
65Heterotopia (HP:0002282)2.00198179
66Median cleft lip (HP:0000161)2.00128997
67Abdominal situs inversus (HP:0003363)1.99832485
68Abnormality of abdominal situs (HP:0011620)1.99832485
69Embryonal renal neoplasm (HP:0011794)1.99514270
70Protruding tongue (HP:0010808)1.99188043
71Supernumerary bones of the axial skeleton (HP:0009144)1.98304356
72Small intestinal stenosis (HP:0012848)1.97888696
73Duodenal stenosis (HP:0100867)1.97888696
74Broad thumb (HP:0011304)1.95910106
75Abnormality of the carotid arteries (HP:0005344)1.95853945
76Biliary tract neoplasm (HP:0100574)1.95181427
77Medial flaring of the eyebrow (HP:0010747)1.95117682
78Osteomalacia (HP:0002749)1.94384929
79Acute myeloid leukemia (HP:0004808)1.93109477
80Myelodysplasia (HP:0002863)1.92189046
81Abnormality of the parietal bone (HP:0002696)1.91400088
82True hermaphroditism (HP:0010459)1.90297356
83Acute lymphatic leukemia (HP:0006721)1.89976008
84Broad alveolar ridges (HP:0000187)1.89447191
85Abnormal lung lobation (HP:0002101)1.89433613
86Gastrointestinal carcinoma (HP:0002672)1.88189596
87Malignant gastrointestinal tract tumors (HP:0006749)1.88189596
88Low anterior hairline (HP:0000294)1.87182246
89Neoplasm of the colon (HP:0100273)1.87116450
90Dysmetric saccades (HP:0000641)1.86065464
91Embryonal neoplasm (HP:0002898)1.85041908
92Abnormality of the incisor (HP:0000676)1.82868285
93Rib fusion (HP:0000902)1.82812959
94Preaxial hand polydactyly (HP:0001177)1.82724683
95Atresia of the external auditory canal (HP:0000413)1.82692246
96Ovarian neoplasm (HP:0100615)1.80374520
97Lip pit (HP:0100267)1.79348911
98Oculomotor apraxia (HP:0000657)1.79170246
99Urethral obstruction (HP:0000796)1.78363478
100Prominent nose (HP:0000448)1.78310041
101Short tibia (HP:0005736)1.78225790
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.77393180
103Poor coordination (HP:0002370)1.77275573
104Neoplasm of the oral cavity (HP:0100649)1.76586642
105Increased number of teeth (HP:0011069)1.75923887
106Sandal gap (HP:0001852)1.75896834
107Skull defect (HP:0001362)1.75284918
108Glioma (HP:0009733)1.75144621
109Breast hypoplasia (HP:0003187)1.75137622
110Mesomelia (HP:0003027)1.75135750
111Gait imbalance (HP:0002141)1.73639356
112Blepharitis (HP:0000498)1.72143123
113Renal duplication (HP:0000075)1.72031437
114Clubbing of toes (HP:0100760)1.71431570
115Abnormality of DNA repair (HP:0003254)1.71150874
116Short thumb (HP:0009778)1.70525260
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.68962274
118Brushfield spots (HP:0001088)1.68273975
119Broad phalanges of the hand (HP:0009768)1.68077261
120Hypoplastic labia majora (HP:0000059)1.67895594
121Neoplasm of the small intestine (HP:0100833)1.67617532
122Sparse lateral eyebrow (HP:0005338)1.67172689
123Ependymoma (HP:0002888)1.66945423
124Dandy-Walker malformation (HP:0001305)1.66870028
125Intestinal fistula (HP:0100819)1.65805100
126Bicuspid aortic valve (HP:0001647)1.64955933
127Hyperglycinuria (HP:0003108)1.64844289
128Abnormality of the phalanges of the hallux (HP:0010057)1.64050847
129Sloping forehead (HP:0000340)1.63606669
130Bile duct proliferation (HP:0001408)1.63155978
131Abnormal biliary tract physiology (HP:0012439)1.63155978
132Asymmetry of the thorax (HP:0001555)1.62994201
133Cystic hygroma (HP:0000476)1.62954583
134Oligodactyly (HP:0012165)1.62331588
135Hypoplasia of the maxilla (HP:0000327)1.61880830
136Abnormality of the duodenum (HP:0002246)1.60214885
137Cafe-au-lait spot (HP:0000957)1.58074690
138Broad finger (HP:0001500)1.57740416
139Cutis marmorata (HP:0000965)1.57392955
140Neoplasm of striated muscle (HP:0009728)1.57307728
141Limited elbow extension (HP:0001377)1.56624262
142Midline defect of the nose (HP:0004122)1.55960264
143Optic nerve coloboma (HP:0000588)1.55453005
144Aplasia/Hypoplasia of the earlobes (HP:0009906)1.55261592
145Anal stenosis (HP:0002025)1.54750569
146Neoplasm of the pancreas (HP:0002894)1.54733146
147Prostate neoplasm (HP:0100787)1.54695336
148Absent thumb (HP:0009777)1.54155740
149Abnormality of chromosome segregation (HP:0002916)1.54135744
150Long clavicles (HP:0000890)1.54015282
151Abnormality of the labia majora (HP:0012881)1.53843781
152Short 5th finger (HP:0009237)1.53176568
153Shawl scrotum (HP:0000049)1.52953402
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52773830
155Short 1st metacarpal (HP:0010034)1.52663772
156Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.52663772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.26236990
2CDK123.79087367
3SRPK12.93837356
4LATS12.93801620
5BRD42.90945057
6MKNK22.90538829
7MKNK12.71764618
8ZAK2.63304227
9TTK2.35214733
10PBK2.31623039
11TRIM282.29317136
12NEK22.20966315
13PLK42.18520321
14CDK192.18255187
15KSR12.00912931
16WEE11.96108724
17STK31.96082631
18BCR1.94182807
19ATR1.91136884
20RAF11.86441029
21PLK31.73714883
22MAP3K41.72518047
23KSR21.70936060
24BUB11.64686869
25ACVR1B1.62603631
26PASK1.61346581
27PLK11.59994753
28AURKB1.55586792
29CHEK21.49331096
30MAP3K131.45771058
31TNIK1.45516388
32CDK61.43996625
33TSSK61.42879709
34CDK71.42360107
35NUAK11.42026546
36STK101.40172591
37CHEK11.40108607
38TAF11.37484196
39FRK1.35663096
40ATM1.33652430
41BRSK21.33318474
42CDK41.31358638
43MAP3K101.29184270
44RPS6KA41.27427330
45WNK11.25726465
46BRSK11.24962981
47STK38L1.23715510
48EIF2AK11.23011926
49MET1.22127717
50STK41.21591557
51NEK91.19666352
52MAP3K91.19183483
53RPS6KB21.18547256
54DYRK31.17656943
55PIM11.15381189
56MELK1.12794136
57CHUK1.10364180
58ERBB31.08176654
59BRAF1.07716846
60RIPK11.05035470
61NEK61.04211700
62MAP3K141.03264953
63VRK11.00878359
64EEF2K0.97896948
65MST40.97012021
66MAP3K20.94847614
67TLK10.94350719
68CDK20.93771358
69CDK90.92518611
70EIF2AK20.91498989
71PINK10.89952926
72CSNK1G10.87885736
73CSNK1A1L0.85953887
74TIE10.85766827
75FGFR30.84606530
76EPHA20.83634323
77MAP2K70.82480648
78CDK10.79292153
79MAP3K80.79215884
80ALK0.78929114
81AKT30.78064826
82CSNK1G30.75411934
83TGFBR10.75160574
84YES10.73773073
85CLK10.72532538
86MTOR0.72531886
87CDK30.72276891
88NLK0.68155214
89STK390.68042220
90SCYL20.67851519
91FGFR10.67458547
92RPS6KB10.63622740
93FLT30.63328639
94SIK30.62761301
95JAK30.61898779
96NEK10.58046285
97IRAK30.57364870
98TEC0.56048098
99PRKDC0.55893817
100CSNK1G20.54860556
101ARAF0.53943835
102MAP4K20.53678430
103AKT10.52999345
104MAPK140.52927078
105MAP3K60.52271952
106PAK40.51842928
107AURKA0.48884894
108RPS6KA50.47924384
109STK240.47761364
110TXK0.45758885
111PAK20.45677504
112IRAK40.45556125
113EPHA30.45235092
114GRK10.44734556
115CSNK2A20.44322636
116PKN20.42884193
117CSNK1D0.42737458
118PIK3CA0.42085506
119BMPR20.41683071
120CSNK2A10.40780641
121BMPR1B0.40675304
122CAMK1D0.39009631
123PTK60.37719119
124SGK30.37699022
125MAPK10.37395156
126RET0.36152451
127GSK3B0.35886483
128LATS20.35777015
129CSNK1E0.35775753
130PDGFRA0.33372102
131MARK30.32186201
132TRPM70.31770713
133DMPK0.31436230
134EIF2AK30.31272565
135PRKCI0.30488763
136MAP2K40.30465190
137PNCK0.30047286
138AKT20.29709191

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.48949691
2Mismatch repair_Homo sapiens_hsa034303.23555748
3Cell cycle_Homo sapiens_hsa041102.97248563
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81104734
5RNA transport_Homo sapiens_hsa030132.70392903
6Spliceosome_Homo sapiens_hsa030402.68958902
7Non-homologous end-joining_Homo sapiens_hsa034502.68715145
8Homologous recombination_Homo sapiens_hsa034402.60796407
9One carbon pool by folate_Homo sapiens_hsa006702.59633520
10Fanconi anemia pathway_Homo sapiens_hsa034602.55021869
11Base excision repair_Homo sapiens_hsa034102.31929865
12Nucleotide excision repair_Homo sapiens_hsa034202.20014801
13mRNA surveillance pathway_Homo sapiens_hsa030152.11670140
14p53 signaling pathway_Homo sapiens_hsa041151.94296989
15RNA degradation_Homo sapiens_hsa030181.93079344
16RNA polymerase_Homo sapiens_hsa030201.79682804
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78430756
18MicroRNAs in cancer_Homo sapiens_hsa052061.63234629
19Basal transcription factors_Homo sapiens_hsa030221.62200279
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49569822
21Herpes simplex infection_Homo sapiens_hsa051681.48396385
22Systemic lupus erythematosus_Homo sapiens_hsa053221.42772843
23Propanoate metabolism_Homo sapiens_hsa006401.41590467
24Adherens junction_Homo sapiens_hsa045201.34011081
25Small cell lung cancer_Homo sapiens_hsa052221.33800634
26Viral carcinogenesis_Homo sapiens_hsa052031.32682536
27Pyrimidine metabolism_Homo sapiens_hsa002401.30637558
28HTLV-I infection_Homo sapiens_hsa051661.28017957
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27536618
30Basal cell carcinoma_Homo sapiens_hsa052171.26321267
31TGF-beta signaling pathway_Homo sapiens_hsa043501.25589166
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.25002301
33Epstein-Barr virus infection_Homo sapiens_hsa051691.24882979
34Regulation of autophagy_Homo sapiens_hsa041401.24725928
35Antigen processing and presentation_Homo sapiens_hsa046121.21731497
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.20610278
37Hippo signaling pathway_Homo sapiens_hsa043901.16650064
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16419191
39Chronic myeloid leukemia_Homo sapiens_hsa052201.11197467
40Steroid biosynthesis_Homo sapiens_hsa001001.10383145
41Prostate cancer_Homo sapiens_hsa052151.08991495
42Measles_Homo sapiens_hsa051621.07680359
43Lysine degradation_Homo sapiens_hsa003101.07400263
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04818674
45Primary immunodeficiency_Homo sapiens_hsa053400.99220744
46Colorectal cancer_Homo sapiens_hsa052100.98756197
47Hepatitis B_Homo sapiens_hsa051610.97601392
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91434555
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90132835
50Notch signaling pathway_Homo sapiens_hsa043300.86190361
51Thyroid cancer_Homo sapiens_hsa052160.86185771
52Inositol phosphate metabolism_Homo sapiens_hsa005620.84807004
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84230373
54Oocyte meiosis_Homo sapiens_hsa041140.83796723
55Hedgehog signaling pathway_Homo sapiens_hsa043400.79180346
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78542144
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78162731
58Phototransduction_Homo sapiens_hsa047440.77593368
59Viral myocarditis_Homo sapiens_hsa054160.75163563
60Pathways in cancer_Homo sapiens_hsa052000.75052961
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74898576
62Hematopoietic cell lineage_Homo sapiens_hsa046400.73696466
63Influenza A_Homo sapiens_hsa051640.73571394
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73407109
65Pancreatic cancer_Homo sapiens_hsa052120.73261686
66Wnt signaling pathway_Homo sapiens_hsa043100.71847934
67Proteoglycans in cancer_Homo sapiens_hsa052050.71823338
68Apoptosis_Homo sapiens_hsa042100.71359273
69Endometrial cancer_Homo sapiens_hsa052130.69263799
70ABC transporters_Homo sapiens_hsa020100.69134728
71Legionellosis_Homo sapiens_hsa051340.68774614
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65906126
73Graft-versus-host disease_Homo sapiens_hsa053320.64959070
74FoxO signaling pathway_Homo sapiens_hsa040680.64517251
75Melanoma_Homo sapiens_hsa052180.63929484
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.63922496
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63765688
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61557954
79T cell receptor signaling pathway_Homo sapiens_hsa046600.59982423
80Bladder cancer_Homo sapiens_hsa052190.59342724
81Proteasome_Homo sapiens_hsa030500.58915680
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58837166
83Purine metabolism_Homo sapiens_hsa002300.58595064
84Non-small cell lung cancer_Homo sapiens_hsa052230.58059958
85Olfactory transduction_Homo sapiens_hsa047400.58018190
86Acute myeloid leukemia_Homo sapiens_hsa052210.57850916
87Ribosome_Homo sapiens_hsa030100.57526276
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.57214019
89Allograft rejection_Homo sapiens_hsa053300.56281589
90Protein export_Homo sapiens_hsa030600.55793837
91Toxoplasmosis_Homo sapiens_hsa051450.55110811
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54132537
93TNF signaling pathway_Homo sapiens_hsa046680.53625452
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53147376
95Alcoholism_Homo sapiens_hsa050340.52866495
96Caffeine metabolism_Homo sapiens_hsa002320.51370835
97Leishmaniasis_Homo sapiens_hsa051400.51317052
98mTOR signaling pathway_Homo sapiens_hsa041500.51062102
99Dorso-ventral axis formation_Homo sapiens_hsa043200.50580525
100Folate biosynthesis_Homo sapiens_hsa007900.50471329
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50224315
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48937856
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45807276
104Focal adhesion_Homo sapiens_hsa045100.45780458
105ECM-receptor interaction_Homo sapiens_hsa045120.44992760
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44035294
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43427127
108Circadian rhythm_Homo sapiens_hsa047100.42661549
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42244796
110Tight junction_Homo sapiens_hsa045300.41417913
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41143262
112Shigellosis_Homo sapiens_hsa051310.40993156
113ErbB signaling pathway_Homo sapiens_hsa040120.40004187
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39842305
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39812490
116B cell receptor signaling pathway_Homo sapiens_hsa046620.39809840
117Selenocompound metabolism_Homo sapiens_hsa004500.39487410
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.38779527
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37958748
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37178153
121Prolactin signaling pathway_Homo sapiens_hsa049170.35133851
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34662524
123Butanoate metabolism_Homo sapiens_hsa006500.34214725
124Osteoclast differentiation_Homo sapiens_hsa043800.32070397
125Hepatitis C_Homo sapiens_hsa051600.31580915
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.29465136
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29076800
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28644700
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27618028
130Fatty acid elongation_Homo sapiens_hsa000620.26786933
131Carbon metabolism_Homo sapiens_hsa012000.26443925
132Ether lipid metabolism_Homo sapiens_hsa005650.25261054
133Peroxisome_Homo sapiens_hsa041460.24633940
134Renal cell carcinoma_Homo sapiens_hsa052110.22234426
135Choline metabolism in cancer_Homo sapiens_hsa052310.19534387
136Long-term depression_Homo sapiens_hsa047300.18629503
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17165800

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