INTS4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of multicellular organism growth (GO:0040015)6.01293432
2sex differentiation (GO:0007548)5.43327064
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.40491683
4piRNA metabolic process (GO:0034587)5.40399487
5regulation of memory T cell differentiation (GO:0043380)5.39888615
6male meiosis I (GO:0007141)5.11477271
7cytoplasmic mRNA processing body assembly (GO:0033962)5.07973262
8synapsis (GO:0007129)5.00218514
9negative regulation of fibroblast apoptotic process (GO:2000270)4.80080924
10cilium or flagellum-dependent cell motility (GO:0001539)4.78399112
11regulation of MHC class I biosynthetic process (GO:0045343)4.69686999
12DNA methylation involved in gamete generation (GO:0043046)4.54413545
13meiosis I (GO:0007127)4.44649079
14regulation of meiosis I (GO:0060631)4.21133730
15male meiosis (GO:0007140)4.17466588
16meiotic chromosome segregation (GO:0045132)4.14714756
17chromosome organization involved in meiosis (GO:0070192)4.11999954
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.10129746
19nucleoside diphosphate catabolic process (GO:0009134)4.02620243
20cellular ketone body metabolic process (GO:0046950)3.92279181
21regulation of establishment of cell polarity (GO:2000114)3.85935057
22kynurenine metabolic process (GO:0070189)3.81429259
23axonemal dynein complex assembly (GO:0070286)3.80269967
24tryptophan catabolic process (GO:0006569)3.80024088
25indole-containing compound catabolic process (GO:0042436)3.80024088
26indolalkylamine catabolic process (GO:0046218)3.80024088
27gamma-aminobutyric acid transport (GO:0015812)3.79124140
28ADP metabolic process (GO:0046031)3.77057556
29negative regulation of mast cell activation (GO:0033004)3.75073000
30regulation of fibroblast apoptotic process (GO:2000269)3.74089872
31cholesterol catabolic process (GO:0006707)3.71858309
32sterol catabolic process (GO:0016127)3.71858309
33cilium movement (GO:0003341)3.71707428
34epithelial cilium movement (GO:0003351)3.57820479
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56329942
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.56329942
37neurotransmitter-gated ion channel clustering (GO:0072578)3.54317084
38synaptonemal complex assembly (GO:0007130)3.52982908
39regulation of interleukin-13 production (GO:0032656)3.51777436
40cerebellar Purkinje cell differentiation (GO:0021702)3.50989130
41positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.49897676
42ketone body metabolic process (GO:1902224)3.42696860
43photoreceptor cell maintenance (GO:0045494)3.34480100
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31753458
45axoneme assembly (GO:0035082)3.30429688
46positive regulation of meiosis (GO:0045836)3.29006736
47L-fucose catabolic process (GO:0042355)3.28800083
48fucose catabolic process (GO:0019317)3.28800083
49L-fucose metabolic process (GO:0042354)3.28800083
50microtubule polymerization or depolymerization (GO:0031109)3.27974818
51meiotic nuclear division (GO:0007126)3.27290114
52synaptonemal complex organization (GO:0070193)3.26974181
53reciprocal DNA recombination (GO:0035825)3.25963897
54reciprocal meiotic recombination (GO:0007131)3.25963897
55meiotic cell cycle process (GO:1903046)3.21367819
56bile acid biosynthetic process (GO:0006699)3.21090922
57base-excision repair, AP site formation (GO:0006285)3.20505235
58indolalkylamine metabolic process (GO:0006586)3.19015314
59synaptic transmission, cholinergic (GO:0007271)3.18221890
60sulfation (GO:0051923)3.17171377
61negative regulation of type 2 immune response (GO:0002829)3.16942268
62regulation of cilium movement (GO:0003352)3.16055754
63behavioral response to nicotine (GO:0035095)3.15170732
64lipid particle organization (GO:0034389)3.13071802
65tryptophan metabolic process (GO:0006568)3.10063940
66protein-cofactor linkage (GO:0018065)3.09428666
67positive regulation of meiotic cell cycle (GO:0051446)3.07876748
68acrosome assembly (GO:0001675)3.06733146
69regulation of action potential (GO:0098900)3.03980097
70regulation of establishment or maintenance of cell polarity (GO:0032878)2.96379065
71seminiferous tubule development (GO:0072520)2.95288900
72protein polyglutamylation (GO:0018095)2.93121822
73detection of light stimulus involved in visual perception (GO:0050908)2.89449705
74detection of light stimulus involved in sensory perception (GO:0050962)2.89449705
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86074774
76regulation of heat generation (GO:0031650)2.84573326
77retinal rod cell development (GO:0046548)2.83354356
78cilium morphogenesis (GO:0060271)2.81155402
79resolution of meiotic recombination intermediates (GO:0000712)2.81087615
80reflex (GO:0060004)2.79918037
81central nervous system neuron axonogenesis (GO:0021955)2.78625738
82regulation of interleukin-5 production (GO:0032674)2.76412261
83positive regulation of vasculogenesis (GO:2001214)2.75745705
84behavioral response to ethanol (GO:0048149)2.74132382
85adaptation of signaling pathway (GO:0023058)2.74100777
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.71896007
87neuronal action potential propagation (GO:0019227)2.71114865
88estrogen biosynthetic process (GO:0006703)2.71075559
89retinal cone cell development (GO:0046549)2.70173146
90intraciliary transport (GO:0042073)2.70161369
91somite rostral/caudal axis specification (GO:0032525)2.70048100
92protein K11-linked deubiquitination (GO:0035871)2.69046398
93auditory receptor cell stereocilium organization (GO:0060088)2.68601422
94sperm motility (GO:0030317)2.67186866
95pyrimidine nucleotide catabolic process (GO:0006244)2.65781756
96detection of mechanical stimulus involved in sensory perception (GO:0050974)2.65206474
97replication fork processing (GO:0031297)2.64396389
98auditory behavior (GO:0031223)2.62555248
99mechanosensory behavior (GO:0007638)2.60108058
100cilium organization (GO:0044782)2.59145316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.77634905
2TAF15_26573619_Chip-Seq_HEK293_Human3.35952948
3EZH2_22144423_ChIP-Seq_EOC_Human3.29710641
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.26960166
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15204487
6GBX2_23144817_ChIP-Seq_PC3_Human3.06221711
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99225013
8ZNF274_21170338_ChIP-Seq_K562_Hela2.83314472
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64073573
10IGF1R_20145208_ChIP-Seq_DFB_Human2.63533456
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59742923
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55483656
13ER_23166858_ChIP-Seq_MCF-7_Human2.45461396
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30448707
15FUS_26573619_Chip-Seq_HEK293_Human2.21084661
16BCAT_22108803_ChIP-Seq_LS180_Human2.17407539
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14236068
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02854964
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.99636662
20P300_19829295_ChIP-Seq_ESCs_Human1.98386745
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97232942
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79434803
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77311040
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76773553
25CBP_20019798_ChIP-Seq_JUKART_Human1.74330803
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74330803
27STAT3_23295773_ChIP-Seq_U87_Human1.72193940
28SMAD4_21799915_ChIP-Seq_A2780_Human1.71152868
29KLF5_20875108_ChIP-Seq_MESCs_Mouse1.71143963
30EWS_26573619_Chip-Seq_HEK293_Human1.70024207
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69126941
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.64560080
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62303358
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61856459
35AR_21572438_ChIP-Seq_LNCaP_Human1.58517362
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57202055
37TCF4_23295773_ChIP-Seq_U87_Human1.56045342
38AR_25329375_ChIP-Seq_VCAP_Human1.53392568
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.47872123
40FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46183774
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45098292
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44387831
43RUNX2_22187159_ChIP-Seq_PCA_Human1.40031261
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.39284276
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.38798405
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38798405
47TCF4_22108803_ChIP-Seq_LS180_Human1.38141123
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36481535
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35718351
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35077446
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.32534450
52TP53_22573176_ChIP-Seq_HFKS_Human1.31391314
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28653164
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28411335
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.27213410
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25424569
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25424569
58CDX2_22108803_ChIP-Seq_LS180_Human1.24814134
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24464136
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.23947655
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.23232054
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23027994
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.22385926
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.21735732
65NANOG_19829295_ChIP-Seq_ESCs_Human1.19111063
66SOX2_19829295_ChIP-Seq_ESCs_Human1.19111063
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18910488
68RXR_22108803_ChIP-Seq_LS180_Human1.17869954
69REST_21632747_ChIP-Seq_MESCs_Mouse1.16866943
70KDM2B_26808549_Chip-Seq_REH_Human1.14501438
71RNF2_27304074_Chip-Seq_NSC_Mouse1.12690623
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12028877
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11626388
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11444212
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11068282
76NCOR_22424771_ChIP-Seq_293T_Human1.11061503
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10392511
78IRF1_19129219_ChIP-ChIP_H3396_Human1.10376975
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.08569187
80TBL1_22424771_ChIP-Seq_293T_Human1.08470622
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07057475
82P53_22387025_ChIP-Seq_ESCs_Mouse1.06128959
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05642228
84PHF8_20622853_ChIP-Seq_HELA_Human1.05331713
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.04312602
86AR_20517297_ChIP-Seq_VCAP_Human1.03252478
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03153672
88NFYB_21822215_ChIP-Seq_K562_Human1.01934129
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00814259
90NFYA_21822215_ChIP-Seq_K562_Human1.00736112
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00614471
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.00137342
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99499436
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.98523036
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.95166404
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.93522343
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93450235
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93131869
99ETV1_20927104_ChIP-Seq_GIST48_Human0.92810684
100SOX2_18555785_Chip-Seq_ESCs_Mouse0.92207290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.34276816
2MP0002736_abnormal_nociception_after3.83619078
3MP0008877_abnormal_DNA_methylation3.58789291
4MP0001968_abnormal_touch/_nociception3.55536954
5MP0003136_yellow_coat_color3.33577573
6MP0003252_abnormal_bile_duct2.89135577
7MP0003646_muscle_fatigue2.48203672
8MP0002102_abnormal_ear_morphology2.43780991
9MP0003195_calcinosis2.41904164
10MP0001986_abnormal_taste_sensitivity2.38086388
11MP0005551_abnormal_eye_electrophysiolog2.27887169
12MP0001501_abnormal_sleep_pattern2.26475489
13MP0009745_abnormal_behavioral_response2.23493732
14MP0009046_muscle_twitch2.20532919
15MP0005410_abnormal_fertilization2.00064755
16MP0000427_abnormal_hair_cycle1.89905854
17MP0005253_abnormal_eye_physiology1.88405542
18MP0005646_abnormal_pituitary_gland1.83268398
19MP0008058_abnormal_DNA_repair1.81051377
20MP0006072_abnormal_retinal_apoptosis1.75357172
21MP0005174_abnormal_tail_pigmentation1.74077458
22MP0002210_abnormal_sex_determination1.74018482
23MP0003698_abnormal_male_reproductive1.66182428
24MP0003011_delayed_dark_adaptation1.64875588
25MP0001929_abnormal_gametogenesis1.62811059
26MP0005670_abnormal_white_adipose1.60528251
27MP0002272_abnormal_nervous_system1.58786813
28MP0000383_abnormal_hair_follicle1.56427639
29MP0002653_abnormal_ependyma_morphology1.54678878
30MP0006276_abnormal_autonomic_nervous1.49999067
31MP0001486_abnormal_startle_reflex1.47956501
32MP0000653_abnormal_sex_gland1.47450592
33MP0001145_abnormal_male_reproductive1.47330395
34MP0005171_absent_coat_pigmentation1.45652701
35MP0003950_abnormal_plasma_membrane1.44986554
36MP0010386_abnormal_urinary_bladder1.44378064
37MP0002234_abnormal_pharynx_morphology1.42193664
38MP0002733_abnormal_thermal_nociception1.41697721
39MP0004147_increased_porphyrin_level1.35227287
40MP0002064_seizures1.34470987
41MP0008995_early_reproductive_senescence1.34091923
42MP0002572_abnormal_emotion/affect_behav1.33481664
43MP0010368_abnormal_lymphatic_system1.32333230
44MP0004742_abnormal_vestibular_system1.28034815
45MP0002735_abnormal_chemical_nociception1.26041434
46MP0005310_abnormal_salivary_gland1.25439991
47MP0002638_abnormal_pupillary_reflex1.23249912
48MP0003119_abnormal_digestive_system1.23166616
49MP0001970_abnormal_pain_threshold1.22532474
50MP0002928_abnormal_bile_duct1.20343138
51MP0005085_abnormal_gallbladder_physiolo1.17602596
52MP0002160_abnormal_reproductive_system1.17397576
53MP0008872_abnormal_physiological_respon1.13172879
54MP0001485_abnormal_pinna_reflex1.11416350
55MP0010094_abnormal_chromosome_stability1.09342337
56MP0005084_abnormal_gallbladder_morpholo1.08051978
57MP0002067_abnormal_sensory_capabilities1.07985830
58MP0001529_abnormal_vocalization1.07203320
59MP0000631_abnormal_neuroendocrine_gland1.06109578
60MP0003635_abnormal_synaptic_transmissio1.03380204
61MP0003137_abnormal_impulse_conducting1.03003487
62MP0002229_neurodegeneration1.02925025
63MP0002557_abnormal_social/conspecific_i1.02291937
64MP0006292_abnormal_olfactory_placode0.98907225
65MP0003787_abnormal_imprinting0.98064266
66MP0004924_abnormal_behavior0.97181681
67MP0005386_behavior/neurological_phenoty0.97181681
68MP0005647_abnormal_sex_gland0.96623416
69MP0000026_abnormal_inner_ear0.96401225
70MP0000371_diluted_coat_color0.95798801
71MP0001346_abnormal_lacrimal_gland0.94434362
72MP0002734_abnormal_mechanical_nocicepti0.93639463
73MP0003890_abnormal_embryonic-extraembry0.92278174
74MP0003718_maternal_effect0.91980985
75MP0002751_abnormal_autonomic_nervous0.90670615
76MP0001502_abnormal_circadian_rhythm0.90523038
77MP0001963_abnormal_hearing_physiology0.90004623
78MP0002063_abnormal_learning/memory/cond0.89310459
79MP0002693_abnormal_pancreas_physiology0.88611049
80MP0001119_abnormal_female_reproductive0.87266686
81MP0005389_reproductive_system_phenotype0.87031341
82MP0002161_abnormal_fertility/fecundity0.84342299
83MP0000516_abnormal_urinary_system0.83509359
84MP0005367_renal/urinary_system_phenotyp0.83509359
85MP0004885_abnormal_endolymph0.82766893
86MP0001879_abnormal_lymphatic_vessel0.79789860
87MP0005645_abnormal_hypothalamus_physiol0.79642658
88MP0005365_abnormal_bile_salt0.79412533
89MP0003633_abnormal_nervous_system0.77867515
90MP0000778_abnormal_nervous_system0.76160486
91MP0008961_abnormal_basal_metabolism0.75437659
92MP0004130_abnormal_muscle_cell0.74585775
93MP0003045_fibrosis0.73770938
94MP0005195_abnormal_posterior_eye0.73269261
95MP0002163_abnormal_gland_morphology0.72443586
96MP0002882_abnormal_neuron_morphology0.71371183
97MP0004215_abnormal_myocardial_fiber0.71074253
98MP0003936_abnormal_reproductive_system0.69455657
99MP0001984_abnormal_olfaction0.68818412
100MP0004142_abnormal_muscle_tone0.68336128

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.52820340
2Progressive cerebellar ataxia (HP:0002073)5.47377506
3Hyperventilation (HP:0002883)4.99786903
4Gaze-evoked nystagmus (HP:0000640)4.56625190
5Action tremor (HP:0002345)4.53647701
6Abnormal ciliary motility (HP:0012262)3.89826568
7Dysmetric saccades (HP:0000641)3.86558742
8Abnormal respiratory motile cilium physiology (HP:0012261)3.72320909
9Absent/shortened dynein arms (HP:0200106)3.61346723
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.61346723
11Abnormal respiratory motile cilium morphology (HP:0005938)3.49162636
12Abnormal respiratory epithelium morphology (HP:0012253)3.49162636
13Toxemia of pregnancy (HP:0100603)3.44079272
14Pendular nystagmus (HP:0012043)3.41234404
15Pancreatic cysts (HP:0001737)3.32569637
16Pancreatic fibrosis (HP:0100732)3.24961379
17Prostate neoplasm (HP:0100787)3.12477789
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.07854536
19Attenuation of retinal blood vessels (HP:0007843)2.98093715
20Bony spicule pigmentary retinopathy (HP:0007737)2.96696597
21Abolished electroretinogram (ERG) (HP:0000550)2.83621766
22Abnormality of the hepatic vasculature (HP:0006707)2.80151311
23Abnormality of the renal cortex (HP:0011035)2.71729258
24Urinary bladder sphincter dysfunction (HP:0002839)2.69511919
25Chorioretinal atrophy (HP:0000533)2.68606287
26Focal seizures (HP:0007359)2.68539845
27True hermaphroditism (HP:0010459)2.64557140
28Absence seizures (HP:0002121)2.62572797
29Abnormality of midbrain morphology (HP:0002418)2.60786357
30Molar tooth sign on MRI (HP:0002419)2.60786357
31Impaired vibratory sensation (HP:0002495)2.57118570
32Limb hypertonia (HP:0002509)2.52816719
33Chronic hepatic failure (HP:0100626)2.51052096
34Postural tremor (HP:0002174)2.48715946
35Congenital stationary night blindness (HP:0007642)2.48180349
36Dysdiadochokinesis (HP:0002075)2.47884520
37Febrile seizures (HP:0002373)2.44334120
38Dialeptic seizures (HP:0011146)2.42934341
39Retinal dysplasia (HP:0007973)2.40786003
40Focal motor seizures (HP:0011153)2.39164391
41Nephronophthisis (HP:0000090)2.37703089
42Bronchiectasis (HP:0002110)2.37571193
43Clumsiness (HP:0002312)2.34951811
44Increased corneal curvature (HP:0100692)2.34228198
45Keratoconus (HP:0000563)2.34228198
46Hemiparesis (HP:0001269)2.29169474
47Horizontal nystagmus (HP:0000666)2.27576017
48Abnormality of the renal medulla (HP:0100957)2.27153920
49Postural instability (HP:0002172)2.25958464
50Hemiplegia (HP:0002301)2.25118957
51Retinitis pigmentosa (HP:0000510)2.25008569
52Tubular atrophy (HP:0000092)2.24406456
53Decreased central vision (HP:0007663)2.22970526
54Sclerocornea (HP:0000647)2.21521888
55Rhinitis (HP:0012384)2.21337832
56Biliary tract neoplasm (HP:0100574)2.21149131
57Generalized aminoaciduria (HP:0002909)2.18185875
58Rhabdomyosarcoma (HP:0002859)2.15929698
59Thyroid-stimulating hormone excess (HP:0002925)2.12215277
60Severe visual impairment (HP:0001141)2.09924080
61Abnormal protein glycosylation (HP:0012346)2.09405074
62Abnormal glycosylation (HP:0012345)2.09405074
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09405074
64Abnormal protein N-linked glycosylation (HP:0012347)2.09405074
65Fair hair (HP:0002286)2.08410276
66Abnormality of macular pigmentation (HP:0008002)2.06838704
67Chromsome breakage (HP:0040012)2.04752673
68Supernumerary spleens (HP:0009799)2.04088002
69Impaired smooth pursuit (HP:0007772)2.02630788
70Medial flaring of the eyebrow (HP:0010747)2.01002267
71Proximal tubulopathy (HP:0000114)1.99254623
72Aplasia/Hypoplasia of the uvula (HP:0010293)1.98915767
73Chronic diarrhea (HP:0002028)1.98175765
74Absent speech (HP:0001344)1.97931731
75Abnormal rod and cone electroretinograms (HP:0008323)1.97004358
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95518740
77Inability to walk (HP:0002540)1.94590705
78Cystic liver disease (HP:0006706)1.93012727
79Broad-based gait (HP:0002136)1.92472129
80Volvulus (HP:0002580)1.92465057
81Abnormal biliary tract morphology (HP:0012440)1.91564531
82Limb ataxia (HP:0002070)1.89579338
83Protruding tongue (HP:0010808)1.89469559
84Oculomotor apraxia (HP:0000657)1.86791885
85Hyperglycinemia (HP:0002154)1.84423557
86Oligodactyly (hands) (HP:0001180)1.81946057
87Abnormal drinking behavior (HP:0030082)1.80364634
88Polydipsia (HP:0001959)1.80364634
89Abnormality of ocular smooth pursuit (HP:0000617)1.80266992
90Hypochromic microcytic anemia (HP:0004840)1.78867718
91Progressive microcephaly (HP:0000253)1.77459359
92Renal cortical cysts (HP:0000803)1.76018359
93Widely spaced teeth (HP:0000687)1.74128669
94Atonic seizures (HP:0010819)1.73045006
95Postaxial foot polydactyly (HP:0001830)1.70276677
96Tubulointerstitial nephritis (HP:0001970)1.69772205
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.68718475
98Agnosia (HP:0010524)1.65176007
99Colon cancer (HP:0003003)1.63632786
100Infertility (HP:0000789)1.63092394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.38073750
2PNCK5.02224773
3CDK194.90281178
4OXSR13.28954247
5BMPR1B2.26440090
6CASK2.16972611
7WEE12.00312076
8MAP4K21.90123266
9INSRR1.88121478
10ZAK1.75161693
11ACVR1B1.73309180
12TAOK31.72297234
13MAPK151.70274637
14MKNK21.62140473
15TSSK61.61690275
16PLK41.61493025
17BRSK21.61040122
18GRK11.53355975
19ADRBK21.46767851
20TAF11.40257166
21STK38L1.28304236
22MET1.26138077
23WNK31.23530362
24MAPK131.21206026
25MST41.13429891
26MAP3K71.13188282
27MAP3K41.12694561
28ITK1.12030554
29PHKG21.10230466
30PHKG11.10230466
31TNK21.09684426
32EIF2AK31.08787317
33NUAK11.07888088
34PTK2B1.05910786
35PINK10.96324341
36TEC0.96141245
37MAPKAPK30.93428317
38STK30.90135140
39PLK20.88341616
40PDK20.86141379
41TTK0.85718242
42TGFBR10.85708116
43CAMKK20.84819921
44TIE10.82668170
45BCR0.79738147
46PKN10.79071583
47CCNB10.78469358
48ERBB20.78292792
49STK380.76741930
50DAPK20.74617138
51FER0.73476432
52MKNK10.70297228
53NTRK30.70097423
54MARK10.69138775
55PIK3CG0.68085530
56CSNK1G10.66724343
57FGFR20.66142608
58STK110.64216031
59EPHB20.63678826
60STK160.61955979
61PRKCE0.58688646
62CDK30.58652896
63PRKAA20.56951368
64CDK80.56234197
65PLK10.56039224
66ADRBK10.55982303
67CSF1R0.54832407
68PRKCG0.51384413
69STK390.51343439
70CSNK1G30.49969495
71CAMK1G0.49530907
72NME10.48512657
73KDR0.48195916
74NTRK20.47509140
75NEK10.47122864
76CSNK1G20.46858405
77PASK0.46056483
78BMX0.45106946
79NLK0.43695879
80CHEK20.43545397
81TXK0.39945765
82MST1R0.39889758
83ROCK10.37585527
84NEK60.37003054
85PIK3CA0.36876479
86CHEK10.36677451
87VRK10.36277380
88WNK40.35743194
89MAPKAPK50.34571966
90BRSK10.33981619
91CAMK10.33507782
92CAMK2A0.32594604
93PRKG10.31245087
94PAK30.31107681
95WNK10.30599076
96IGF1R0.30458523
97PRKCQ0.30361166
98BCKDK0.28991598
99DYRK20.27042551
100SGK10.25847759

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.95560658
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08241565
3Propanoate metabolism_Homo sapiens_hsa006402.62852300
4Butanoate metabolism_Homo sapiens_hsa006502.44300119
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41497299
6Fanconi anemia pathway_Homo sapiens_hsa034602.32390525
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30686895
8Phototransduction_Homo sapiens_hsa047442.23513903
9Homologous recombination_Homo sapiens_hsa034402.20839598
10Olfactory transduction_Homo sapiens_hsa047402.12549904
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10301810
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01118567
13RNA polymerase_Homo sapiens_hsa030202.00798015
14Dorso-ventral axis formation_Homo sapiens_hsa043201.92477080
15Caffeine metabolism_Homo sapiens_hsa002321.87152348
16Taste transduction_Homo sapiens_hsa047421.83528446
17Nicotine addiction_Homo sapiens_hsa050331.81431188
18Non-homologous end-joining_Homo sapiens_hsa034501.64197453
19Tryptophan metabolism_Homo sapiens_hsa003801.62493126
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60722677
21ABC transporters_Homo sapiens_hsa020101.59166354
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56421738
23Basal transcription factors_Homo sapiens_hsa030221.56092199
24Linoleic acid metabolism_Homo sapiens_hsa005911.55716389
25Fatty acid biosynthesis_Homo sapiens_hsa000611.55654672
26Nitrogen metabolism_Homo sapiens_hsa009101.52594979
27Retinol metabolism_Homo sapiens_hsa008301.45177571
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.43480235
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33989065
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.33426041
31Mismatch repair_Homo sapiens_hsa034301.24094879
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22213088
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18578347
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14181330
35Selenocompound metabolism_Homo sapiens_hsa004501.12295155
36Ether lipid metabolism_Homo sapiens_hsa005651.11124544
37Circadian rhythm_Homo sapiens_hsa047101.10260785
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09302025
39Glycerolipid metabolism_Homo sapiens_hsa005611.08454471
40beta-Alanine metabolism_Homo sapiens_hsa004101.01532195
41Peroxisome_Homo sapiens_hsa041461.01460735
42Salivary secretion_Homo sapiens_hsa049701.00321325
43Purine metabolism_Homo sapiens_hsa002300.96548784
44GABAergic synapse_Homo sapiens_hsa047270.96371364
45Calcium signaling pathway_Homo sapiens_hsa040200.96093796
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82305765
47Glutamatergic synapse_Homo sapiens_hsa047240.81005454
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80368823
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78555889
50Morphine addiction_Homo sapiens_hsa050320.75080414
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69821229
52Type I diabetes mellitus_Homo sapiens_hsa049400.68101475
53PPAR signaling pathway_Homo sapiens_hsa033200.67775938
54Chemical carcinogenesis_Homo sapiens_hsa052040.61707408
55Pyruvate metabolism_Homo sapiens_hsa006200.60662552
56Insulin secretion_Homo sapiens_hsa049110.60578995
57Primary immunodeficiency_Homo sapiens_hsa053400.58398271
58cAMP signaling pathway_Homo sapiens_hsa040240.58263864
59Histidine metabolism_Homo sapiens_hsa003400.55453476
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53790046
61Regulation of autophagy_Homo sapiens_hsa041400.53451989
62Allograft rejection_Homo sapiens_hsa053300.53414979
63Autoimmune thyroid disease_Homo sapiens_hsa053200.53091206
64Huntingtons disease_Homo sapiens_hsa050160.52970614
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52201649
66Steroid biosynthesis_Homo sapiens_hsa001000.52140486
67Fatty acid metabolism_Homo sapiens_hsa012120.52072437
68Pyrimidine metabolism_Homo sapiens_hsa002400.50511894
69Fatty acid degradation_Homo sapiens_hsa000710.49526974
70Graft-versus-host disease_Homo sapiens_hsa053320.49009518
71Circadian entrainment_Homo sapiens_hsa047130.47561608
72RNA degradation_Homo sapiens_hsa030180.46393282
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45907112
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45545252
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.45535266
76TGF-beta signaling pathway_Homo sapiens_hsa043500.44404309
77Sphingolipid metabolism_Homo sapiens_hsa006000.44244178
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43602690
79Mineral absorption_Homo sapiens_hsa049780.42696944
80Serotonergic synapse_Homo sapiens_hsa047260.41252103
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.40445278
82Base excision repair_Homo sapiens_hsa034100.40179407
83Axon guidance_Homo sapiens_hsa043600.39721378
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.39568612
85Renin secretion_Homo sapiens_hsa049240.38694936
86Metabolic pathways_Homo sapiens_hsa011000.38389528
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38372076
88Lysine degradation_Homo sapiens_hsa003100.37144180
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36355201
90Oxidative phosphorylation_Homo sapiens_hsa001900.36129954
91Oocyte meiosis_Homo sapiens_hsa041140.35396573
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34147408
93Nucleotide excision repair_Homo sapiens_hsa034200.33839795
94Cell cycle_Homo sapiens_hsa041100.32542074
95Parkinsons disease_Homo sapiens_hsa050120.31259824
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30528292
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.30206804
98Collecting duct acid secretion_Homo sapiens_hsa049660.28538255
99Oxytocin signaling pathway_Homo sapiens_hsa049210.28392316
100Ovarian steroidogenesis_Homo sapiens_hsa049130.27651790

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