INTS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast apoptotic process (GO:2000270)5.91082611
2retinal rod cell development (GO:0046548)5.32197175
3DNA unwinding involved in DNA replication (GO:0006268)5.06835258
4regulation of fibroblast apoptotic process (GO:2000269)4.97945360
5nuclear pore organization (GO:0006999)4.77264786
6nucleobase biosynthetic process (GO:0046112)4.75379818
7nuclear pore complex assembly (GO:0051292)4.62336037
8positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.61846983
9proline biosynthetic process (GO:0006561)4.48712503
10proteasome assembly (GO:0043248)4.47080896
11DNA replication initiation (GO:0006270)4.41754006
12DNA strand elongation involved in DNA replication (GO:0006271)4.40863977
13IMP biosynthetic process (GO:0006188)4.40709313
14protein localization to kinetochore (GO:0034501)4.39345094
15purine nucleobase biosynthetic process (GO:0009113)4.35425408
16mitotic metaphase plate congression (GO:0007080)4.31839451
17cell wall macromolecule catabolic process (GO:0016998)4.31092885
18mitotic nuclear envelope disassembly (GO:0007077)4.29903558
19protein-cofactor linkage (GO:0018065)4.28650777
20DNA strand elongation (GO:0022616)4.17553334
21formation of translation preinitiation complex (GO:0001731)4.01507954
22melanin biosynthetic process (GO:0042438)3.98742199
23IMP metabolic process (GO:0046040)3.94468437
24membrane disassembly (GO:0030397)3.93014403
25nuclear envelope disassembly (GO:0051081)3.93014403
26telomere maintenance via semi-conservative replication (GO:0032201)3.88968133
27DNA replication checkpoint (GO:0000076)3.88875690
28folic acid-containing compound biosynthetic process (GO:0009396)3.88838319
29non-recombinational repair (GO:0000726)3.77897568
30double-strand break repair via nonhomologous end joining (GO:0006303)3.77897568
31mitochondrial RNA metabolic process (GO:0000959)3.77305554
32melanin metabolic process (GO:0006582)3.77124804
33metaphase plate congression (GO:0051310)3.75240449
34secondary metabolite biosynthetic process (GO:0044550)3.72600724
35regulation of spindle organization (GO:0090224)3.71002296
36DNA replication-dependent nucleosome organization (GO:0034723)3.64849953
37DNA replication-dependent nucleosome assembly (GO:0006335)3.64849953
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63045847
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.63045847
40attachment of spindle microtubules to kinetochore (GO:0008608)3.61850636
41ribosome assembly (GO:0042255)3.61433195
42protein localization to chromosome, centromeric region (GO:0071459)3.60215109
43replication fork processing (GO:0031297)3.60010499
44somatic diversification of immunoglobulins (GO:0016445)3.54532041
45telomere maintenance via recombination (GO:0000722)3.53946155
46pore complex assembly (GO:0046931)3.52023517
47regulation of helicase activity (GO:0051095)3.51347997
48mitotic recombination (GO:0006312)3.48915175
49DNA duplex unwinding (GO:0032508)3.47382971
50kinetochore assembly (GO:0051382)3.47256274
51DNA geometric change (GO:0032392)3.46074688
52cell wall macromolecule metabolic process (GO:0044036)3.42943186
53mitotic sister chromatid cohesion (GO:0007064)3.41594098
54mitotic chromosome condensation (GO:0007076)3.40030490
55tRNA aminoacylation for protein translation (GO:0006418)3.39899429
56tRNA aminoacylation (GO:0043039)3.34355627
57amino acid activation (GO:0043038)3.34355627
58ribosome biogenesis (GO:0042254)3.33016009
59telomere maintenance via telomere lengthening (GO:0010833)3.31669101
60establishment of chromosome localization (GO:0051303)3.30169424
61protein deneddylation (GO:0000338)3.26256531
62regulation of DNA endoreduplication (GO:0032875)3.24887101
63negative regulation of chromosome segregation (GO:0051985)3.22857952
64regulation of mitotic spindle organization (GO:0060236)3.22680962
65histone H2A acetylation (GO:0043968)3.21780218
66positive regulation of chromosome segregation (GO:0051984)3.21288119
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21133308
68negative regulation of sister chromatid segregation (GO:0033046)3.21133308
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.21133308
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21133308
71spindle assembly checkpoint (GO:0071173)3.20593200
72mitotic spindle assembly checkpoint (GO:0007094)3.20319928
73somatic diversification of immune receptors (GO:0002200)3.15559578
74chromatin remodeling at centromere (GO:0031055)3.15348519
75nuclear envelope organization (GO:0006998)3.14276967
76regulation of chromosome segregation (GO:0051983)3.12710582
77CENP-A containing nucleosome assembly (GO:0034080)3.12449412
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11312168
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10989675
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10024210
81somatic recombination of immunoglobulin gene segments (GO:0016447)3.09805642
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.09399687
83spindle checkpoint (GO:0031577)3.09249339
84regulation of transcription from RNA polymerase III promoter (GO:0006359)3.09170346
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07833529
86negative regulation of osteoblast proliferation (GO:0033689)3.07229524
87cullin deneddylation (GO:0010388)3.06147171
88response to pheromone (GO:0019236)3.05963450
89regulation of mitotic spindle checkpoint (GO:1903504)3.05373190
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05373190
91mitotic spindle checkpoint (GO:0071174)3.05234471
92regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.03112858
93DNA replication-independent nucleosome assembly (GO:0006336)3.02473032
94DNA replication-independent nucleosome organization (GO:0034724)3.02473032
95myelin assembly (GO:0032288)3.01932083
96* snRNA processing (GO:0016180)3.01054057
97regulation of translational fidelity (GO:0006450)3.00940384
98sister chromatid segregation (GO:0000819)3.00883900
99proline metabolic process (GO:0006560)3.00347243
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00297534
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99210052
102isotype switching (GO:0045190)2.99210052
103somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99210052
104recombinational repair (GO:0000725)2.96575373
105mitotic sister chromatid segregation (GO:0000070)2.96232547
106maturation of SSU-rRNA (GO:0030490)2.95527305
107DNA ligation (GO:0006266)2.95305364
108kinetochore organization (GO:0051383)2.95187761
109regulation of histone H3-K9 methylation (GO:0051570)2.92733657
110double-strand break repair via homologous recombination (GO:0000724)2.92585838
111regulation of acyl-CoA biosynthetic process (GO:0050812)2.92566061
112mismatch repair (GO:0006298)2.91000516
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90387527
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90387527
115DNA conformation change (GO:0071103)2.89432533
116telomere organization (GO:0032200)2.88408878
117telomere maintenance (GO:0000723)2.87961673
118regulation of centriole replication (GO:0046599)2.87603384
119regulation of mitotic sister chromatid separation (GO:0010965)2.87432916
120regulation of mitotic sister chromatid segregation (GO:0033047)2.87432916
121regulation of sister chromatid segregation (GO:0033045)2.87432916
122* snRNA metabolic process (GO:0016073)2.86287433
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85980303
124termination of RNA polymerase I transcription (GO:0006363)2.85482002
125regulation of coenzyme metabolic process (GO:0051196)2.84687491
126regulation of cofactor metabolic process (GO:0051193)2.84687491
127monoubiquitinated protein deubiquitination (GO:0035520)2.83332377
128L-serine metabolic process (GO:0006563)2.82869985
129regulation of sister chromatid cohesion (GO:0007063)2.82865831
130transcription elongation from RNA polymerase I promoter (GO:0006362)2.82829660
131negative regulation of histone methylation (GO:0031061)2.82567474
132regulation of centrosome cycle (GO:0046605)2.82087462
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81038074
134somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80843682
135somatic cell DNA recombination (GO:0016444)2.80843682
136histone exchange (GO:0043486)2.79621718
137postreplication repair (GO:0006301)2.78756357
138regulation of RNA export from nucleus (GO:0046831)2.78399296
139protein localization to chromosome (GO:0034502)2.76779435
140GMP metabolic process (GO:0046037)2.76563817
141ATP-dependent chromatin remodeling (GO:0043044)2.75728035
142dosage compensation (GO:0007549)2.75503514
143protein neddylation (GO:0045116)2.75331125
144translesion synthesis (GO:0019985)2.75285730
145microtubule anchoring (GO:0034453)2.75275025
146regulation of posttranscriptional gene silencing (GO:0060147)2.74344071
147regulation of gene silencing by miRNA (GO:0060964)2.74344071
148regulation of gene silencing by RNA (GO:0060966)2.74344071
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73667654
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73359008
151meiotic chromosome segregation (GO:0045132)2.72625606
152tRNA metabolic process (GO:0006399)2.71407525
153RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71130542
154mRNA splicing, via spliceosome (GO:0000398)2.71130542
155RNA splicing, via transesterification reactions (GO:0000375)2.70709028
156DNA topological change (GO:0006265)2.69031311
157transcription-coupled nucleotide-excision repair (GO:0006283)2.68982225
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66916652
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66916652
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66916652
161ribonucleoprotein complex biogenesis (GO:0022613)2.65238792
162DNA double-strand break processing (GO:0000729)2.64997025
163synapsis (GO:0007129)2.64812524
164signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64116317
165intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64116317
166chaperone-mediated protein complex assembly (GO:0051131)2.64000466
167signal transduction involved in cell cycle checkpoint (GO:0072395)2.63859949
168DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63850651
169DNA strand renaturation (GO:0000733)2.62538812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.12104552
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.13937099
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92586635
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49083284
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33660956
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92109793
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79127793
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64940981
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.55946018
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51774241
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.47126934
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37491747
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26195157
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.24931391
15AR_21909140_ChIP-Seq_LNCAP_Human2.21756491
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19391044
17XRN2_22483619_ChIP-Seq_HELA_Human2.17396844
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.17006694
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16579305
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15034733
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08012112
22* E2F1_21310950_ChIP-Seq_MCF-7_Human2.04445537
23CIITA_25753668_ChIP-Seq_RAJI_Human2.03491452
24MYC_22102868_ChIP-Seq_BL_Human1.97000730
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92306381
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88912911
27* VDR_23849224_ChIP-Seq_CD4+_Human1.86857243
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85045368
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84998396
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84886658
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82450521
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79516345
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.78421270
34ZNF274_21170338_ChIP-Seq_K562_Hela1.73127768
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71110792
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68302298
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67544881
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67101846
39* GABP_19822575_ChIP-Seq_HepG2_Human1.65536658
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64249352
41DCP1A_22483619_ChIP-Seq_HELA_Human1.62073082
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56587385
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56038289
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50917409
45TTF2_22483619_ChIP-Seq_HELA_Human1.48198228
46KDM5A_27292631_Chip-Seq_BREAST_Human1.47086997
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46734361
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45326193
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42438266
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42226457
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42106338
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41482653
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40523592
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37258584
55ELK1_19687146_ChIP-ChIP_HELA_Human1.34687733
56VDR_22108803_ChIP-Seq_LS180_Human1.34600829
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32887949
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32294866
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28612833
60* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26810361
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26196346
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25712455
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.24150987
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.23761764
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23723917
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21289430
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20999879
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20449990
69TFEB_21752829_ChIP-Seq_HELA_Human1.20335458
70EWS_26573619_Chip-Seq_HEK293_Human1.17424544
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.17223564
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15071958
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14649735
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12759253
75MYC_18940864_ChIP-ChIP_HL60_Human1.12331145
76* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11829239
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10704680
78TAF15_26573619_Chip-Seq_HEK293_Human1.09818416
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09011920
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08405120
81IGF1R_20145208_ChIP-Seq_DFB_Human1.05411279
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03202390
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.01981976
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01232790
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01003055
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00630600
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98569774
88VDR_21846776_ChIP-Seq_THP-1_Human0.98522601
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98447476
90IRF1_19129219_ChIP-ChIP_H3396_Human0.97160722
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97022367
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96172346
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92615951
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92441850
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91702277
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90857824
97FUS_26573619_Chip-Seq_HEK293_Human0.90109004
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89833504
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89617267
100FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89331141
101* SPI1_23547873_ChIP-Seq_NB4_Human0.88242961
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87656680
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87604238
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87220262
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86933879
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86792926
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86514070
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86352123
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.85585187
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85078492
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84877086
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83968421
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83520954
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.82876104
115TP53_22573176_ChIP-Seq_HFKS_Human0.82286866
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81850346
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81768450
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81575183
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80621703
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80605265
121CBP_20019798_ChIP-Seq_JUKART_Human0.80605265
122* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77858650
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73672257
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73213805
125MYB_26560356_Chip-Seq_TH2_Human0.72088477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.89175092
2MP0003693_abnormal_embryo_hatching4.71472774
3MP0010094_abnormal_chromosome_stability4.27408226
4MP0008057_abnormal_DNA_replication4.06596902
5MP0003111_abnormal_nucleus_morphology3.83803491
6MP0004957_abnormal_blastocyst_morpholog3.79697939
7MP0003077_abnormal_cell_cycle3.71975681
8MP0003136_yellow_coat_color3.28126407
9MP0008058_abnormal_DNA_repair3.15251843
10MP0005075_abnormal_melanosome_morpholog3.05647822
11MP0002102_abnormal_ear_morphology3.00760608
12MP0010352_gastrointestinal_tract_polyps2.78833753
13MP0008007_abnormal_cellular_replicative2.72260106
14MP0002396_abnormal_hematopoietic_system2.66352759
15MP0005408_hypopigmentation2.52789394
16MP0001730_embryonic_growth_arrest2.51891862
17MP0003787_abnormal_imprinting2.45749684
18MP0000015_abnormal_ear_pigmentation2.43293871
19MP0004147_increased_porphyrin_level2.37872653
20MP0006292_abnormal_olfactory_placode2.33699695
21MP0000350_abnormal_cell_proliferation2.18589389
22MP0008932_abnormal_embryonic_tissue2.10833234
23MP0003646_muscle_fatigue2.06656490
24MP0010307_abnormal_tumor_latency2.05065474
25MP0008877_abnormal_DNA_methylation1.96994480
26MP0008789_abnormal_olfactory_epithelium1.87907365
27MP0001672_abnormal_embryogenesis/_devel1.80258915
28MP0005380_embryogenesis_phenotype1.80258915
29MP0001697_abnormal_embryo_size1.75798869
30MP0000569_abnormal_digit_pigmentation1.74719634
31MP0004381_abnormal_hair_follicle1.70778057
32MP0003786_premature_aging1.68276022
33MP0003984_embryonic_growth_retardation1.68070075
34MP0002938_white_spotting1.66894305
35MP0000537_abnormal_urethra_morphology1.66865839
36MP0003123_paternal_imprinting1.66752613
37MP0002095_abnormal_skin_pigmentation1.64405064
38MP0002088_abnormal_embryonic_growth/wei1.64330293
39MP0004808_abnormal_hematopoietic_stem1.64328521
40MP0005174_abnormal_tail_pigmentation1.62549561
41MP0003567_abnormal_fetal_cardiomyocyte1.62130715
42MP0005076_abnormal_cell_differentiation1.60849678
43MP0001324_abnormal_eye_pigmentation1.59885473
44MP0003806_abnormal_nucleotide_metabolis1.56008634
45MP0002080_prenatal_lethality1.55462405
46MP0002085_abnormal_embryonic_tissue1.52412858
47MP0005171_absent_coat_pigmentation1.51798420
48MP0008995_early_reproductive_senescence1.50587643
49MP0005248_abnormal_Harderian_gland1.48690019
50MP0002084_abnormal_developmental_patter1.46769887
51MP0006035_abnormal_mitochondrial_morpho1.45643252
52MP0002086_abnormal_extraembryonic_tissu1.44868775
53MP0005499_abnormal_olfactory_system1.43996577
54MP0005394_taste/olfaction_phenotype1.43996577
55MP0004197_abnormal_fetal_growth/weight/1.38458992
56MP0000313_abnormal_cell_death1.37434876
57MP0002653_abnormal_ependyma_morphology1.36669165
58MP0002019_abnormal_tumor_incidence1.32735795
59MP0001293_anophthalmia1.29635515
60MP0009697_abnormal_copulation1.28910059
61MP0003763_abnormal_thymus_physiology1.26099442
62MP0005397_hematopoietic_system_phenotyp1.25299843
63MP0001545_abnormal_hematopoietic_system1.25299843
64MP0000490_abnormal_crypts_of1.23346636
65MP0001529_abnormal_vocalization1.22530465
66MP0003221_abnormal_cardiomyocyte_apopto1.19322634
67MP0002009_preneoplasia1.16882303
68MP0002877_abnormal_melanocyte_morpholog1.15535769
69MP0001986_abnormal_taste_sensitivity1.12788183
70MP0002210_abnormal_sex_determination1.10180568
71MP0003566_abnormal_cell_adhesion1.09563774
72MP0001849_ear_inflammation1.09375649
73MP0005551_abnormal_eye_electrophysiolog1.07539664
74MP0010030_abnormal_orbit_morphology1.06107228
75MP0004084_abnormal_cardiac_muscle1.03260134
76MP0000703_abnormal_thymus_morphology1.02821337
77MP0005253_abnormal_eye_physiology1.02211645
78MP0002398_abnormal_bone_marrow1.01148611
79MP0009333_abnormal_splenocyte_physiolog1.00000523
80MP0005310_abnormal_salivary_gland0.99928026
81MP0001145_abnormal_male_reproductive0.98128072
82MP0006054_spinal_hemorrhage0.97889940
83MP0003121_genomic_imprinting0.97658361
84MP0003718_maternal_effect0.96647966
85MP0003890_abnormal_embryonic-extraembry0.95754250
86MP0001873_stomach_inflammation0.95416231
87MP0003656_abnormal_erythrocyte_physiolo0.92658096
88MP0003122_maternal_imprinting0.92468182
89MP0009278_abnormal_bone_marrow0.90145149
90MP0001929_abnormal_gametogenesis0.89868160
91MP0005023_abnormal_wound_healing0.89502125
92MP0002722_abnormal_immune_system0.88571588
93MP0000689_abnormal_spleen_morphology0.88118233
94MP0003705_abnormal_hypodermis_morpholog0.88098861
95MP0001661_extended_life_span0.87258758
96MP0001346_abnormal_lacrimal_gland0.87082610
97MP0001915_intracranial_hemorrhage0.86711177
98MP0001853_heart_inflammation0.86706879
99MP0001764_abnormal_homeostasis0.86543658
100MP0000427_abnormal_hair_cycle0.86327646
101MP0005621_abnormal_cell_physiology0.85910392
102MP0000733_abnormal_muscle_development0.84872314
103MP0005671_abnormal_response_to0.84684309
104MP0001835_abnormal_antigen_presentation0.83851912
105MP0000653_abnormal_sex_gland0.83399562
106MP0005257_abnormal_intraocular_pressure0.83392130
107MP0005384_cellular_phenotype0.82852116
108MP0004142_abnormal_muscle_tone0.82463031
109MP0003878_abnormal_ear_physiology0.81848014
110MP0005377_hearing/vestibular/ear_phenot0.81848014
111MP0004264_abnormal_extraembryonic_tissu0.81800777
112MP0004233_abnormal_muscle_weight0.81409447
113MP0003943_abnormal_hepatobiliary_system0.81305303
114MP0009672_abnormal_birth_weight0.81100408
115MP0005670_abnormal_white_adipose0.80864997
116MP0002429_abnormal_blood_cell0.79859156
117MP0003119_abnormal_digestive_system0.78624950
118MP0002269_muscular_atrophy0.78194179
119MP0001119_abnormal_female_reproductive0.77441352
120MP0002075_abnormal_coat/hair_pigmentati0.77382486
121MP0001800_abnormal_humoral_immune0.72654087
122MP0008875_abnormal_xenobiotic_pharmacok0.70954646
123MP0000358_abnormal_cell_content/0.70725495
124MP0003186_abnormal_redox_activity0.70417847
125MP0000371_diluted_coat_color0.70217750
126MP0002177_abnormal_outer_ear0.69808485
127MP0010630_abnormal_cardiac_muscle0.69802999
128MP0002751_abnormal_autonomic_nervous0.69473499
129MP0000716_abnormal_immune_system0.68838431
130MP0009703_decreased_birth_body0.67922529
131MP0002092_abnormal_eye_morphology0.67840923
132MP0002166_altered_tumor_susceptibility0.67677523
133MP0000465_gastrointestinal_hemorrhage0.67410523
134MP0003195_calcinosis0.66992850
135MP0003698_abnormal_male_reproductive0.66045201
136MP0000428_abnormal_craniofacial_morphol0.65589065
137MP0002928_abnormal_bile_duct0.65437024
138MP0000858_altered_metastatic_potential0.65425749
139MP0003937_abnormal_limbs/digits/tail_de0.64415634
140MP0000685_abnormal_immune_system0.64348395
141MP0005391_vision/eye_phenotype0.64060519
142MP0009053_abnormal_anal_canal0.63468798
143MP0009840_abnormal_foam_cell0.61980524
144MP0000613_abnormal_salivary_gland0.61672756
145MP0005266_abnormal_metabolism0.61666222
146MP0004133_heterotaxia0.61504032
147MP0002111_abnormal_tail_morphology0.60960867
148MP0000266_abnormal_heart_morphology0.60172564
149MP0002233_abnormal_nose_morphology0.60099416
150MP0002925_abnormal_cardiovascular_devel0.60068244
151MP0000477_abnormal_intestine_morphology0.59993586
152MP0005367_renal/urinary_system_phenotyp0.59900551
153MP0000516_abnormal_urinary_system0.59900551

Predicted human phenotypes

RankGene SetZ-score
1Toxemia of pregnancy (HP:0100603)4.62784288
2Birth length less than 3rd percentile (HP:0003561)4.39484345
3Colon cancer (HP:0003003)4.19100165
4Ependymoma (HP:0002888)3.77588646
5Selective tooth agenesis (HP:0001592)3.69875170
6Retinal dysplasia (HP:0007973)3.66608637
7Degeneration of anterior horn cells (HP:0002398)3.63907070
8Abnormality of the anterior horn cell (HP:0006802)3.63907070
9Medulloblastoma (HP:0002885)3.33570606
10Limb hypertonia (HP:0002509)3.30311558
11Patellar aplasia (HP:0006443)3.18726561
12Breast hypoplasia (HP:0003187)3.16433791
13Impulsivity (HP:0100710)3.09725035
14Aplasia/Hypoplasia of the patella (HP:0006498)2.99339263
15Chromsome breakage (HP:0040012)2.95681006
16Abnormality of the labia minora (HP:0012880)2.89334342
17Short 4th metacarpal (HP:0010044)2.88330500
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88330500
19Oral leukoplakia (HP:0002745)2.87532011
20Ectopic kidney (HP:0000086)2.81952355
21Medial flaring of the eyebrow (HP:0010747)2.78965332
22Congenital primary aphakia (HP:0007707)2.70542612
23Neoplasm of the oral cavity (HP:0100649)2.70419123
24Proximal placement of thumb (HP:0009623)2.70129493
25Abnormality of chromosome stability (HP:0003220)2.70024077
26Pancreatic cysts (HP:0001737)2.69819638
27Agnosia (HP:0010524)2.68357536
28Carpal bone hypoplasia (HP:0001498)2.68144753
29Upper limb muscle weakness (HP:0003484)2.63969629
30Nephrogenic diabetes insipidus (HP:0009806)2.63446836
31Deviation of the thumb (HP:0009603)2.62677351
32Neoplasm of the pancreas (HP:0002894)2.62510870
33Entropion (HP:0000621)2.62206439
34Abnormality of DNA repair (HP:0003254)2.59752714
35Pancreatic fibrosis (HP:0100732)2.55503514
36Rhabdomyosarcoma (HP:0002859)2.54585092
37Gait imbalance (HP:0002141)2.50505006
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48999696
39Adrenal hypoplasia (HP:0000835)2.48018728
40Absent radius (HP:0003974)2.46909095
41Ocular albinism (HP:0001107)2.46677416
42Basal cell carcinoma (HP:0002671)2.46430242
43Aplasia/Hypoplasia of the macula (HP:0008059)2.45146106
44Hypoplasia of the fovea (HP:0007750)2.44316435
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.44316435
46Chronic hepatic failure (HP:0100626)2.40840325
47Abnormality of the astrocytes (HP:0100707)2.38869426
48Astrocytoma (HP:0009592)2.38869426
49Increased nuchal translucency (HP:0010880)2.38366085
50Abnormality of the preputium (HP:0100587)2.38321980
51Freckling (HP:0001480)2.38101681
52Biliary tract neoplasm (HP:0100574)2.37569514
53Volvulus (HP:0002580)2.36433311
54Molar tooth sign on MRI (HP:0002419)2.35921117
55Abnormality of midbrain morphology (HP:0002418)2.35921117
56Iris hypopigmentation (HP:0007730)2.35798630
57Long eyelashes (HP:0000527)2.35608786
58Reticulocytopenia (HP:0001896)2.31499974
59Astigmatism (HP:0000483)2.30017354
60Amaurosis fugax (HP:0100576)2.29551977
61Abnormal lung lobation (HP:0002101)2.28810494
62Hyperglycinemia (HP:0002154)2.27351842
63Glioma (HP:0009733)2.27256905
64Rough bone trabeculation (HP:0100670)2.27223808
65Aplasia/Hypoplasia affecting the retina (HP:0008061)2.26435372
66Cerebral hypomyelination (HP:0006808)2.26298377
67Aplasia involving forearm bones (HP:0009822)2.24296247
68Absent forearm bone (HP:0003953)2.24296247
69Multiple enchondromatosis (HP:0005701)2.23232758
70Prominent nose (HP:0000448)2.22314046
71Atresia of the external auditory canal (HP:0000413)2.22253193
72Abnormality of the 4th metacarpal (HP:0010012)2.21743834
73Poor coordination (HP:0002370)2.21325693
74Ovarian neoplasm (HP:0100615)2.20280230
75Myelodysplasia (HP:0002863)2.20112976
76Small intestinal stenosis (HP:0012848)2.20063182
77Duodenal stenosis (HP:0100867)2.20063182
78Meckel diverticulum (HP:0002245)2.18398075
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.17565759
80Abnormality of the renal cortex (HP:0011035)2.17442268
81Neoplasm of the colon (HP:0100273)2.16755297
82Acute encephalopathy (HP:0006846)2.16193519
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16164884
84Long clavicles (HP:0000890)2.14871311
85Abdominal situs inversus (HP:0003363)2.13064004
86Abnormality of abdominal situs (HP:0011620)2.13064004
8711 pairs of ribs (HP:0000878)2.12424504
88Premature graying of hair (HP:0002216)2.11869278
89Congenital stationary night blindness (HP:0007642)2.08934839
90Sloping forehead (HP:0000340)2.08483681
91Abnormality of glycolysis (HP:0004366)2.07730856
92Genital tract atresia (HP:0001827)2.04817810
93IgM deficiency (HP:0002850)2.04556039
94Horseshoe kidney (HP:0000085)2.04358882
95Abnormality of the ileum (HP:0001549)2.03536141
96Renal cortical cysts (HP:0000803)2.03330339
97Absent thumb (HP:0009777)2.03252250
98Facial cleft (HP:0002006)2.02888231
99Blepharitis (HP:0000498)2.00964966
100Bone marrow hypocellularity (HP:0005528)2.00812319
101Cortical dysplasia (HP:0002539)2.00449550
102Cafe-au-lait spot (HP:0000957)1.99392289
103Poikiloderma (HP:0001029)1.98796827
104Lissencephaly (HP:0001339)1.98008920
105Neoplasm of the rectum (HP:0100743)1.96012894
106Abnormality of the fovea (HP:0000493)1.95938457
107Abnormality of the calcaneus (HP:0008364)1.94977203
108Gaze-evoked nystagmus (HP:0000640)1.94938588
109Missing ribs (HP:0000921)1.94661613
110Progressive microcephaly (HP:0000253)1.93274149
111Increased serum pyruvate (HP:0003542)1.93039998
112Long foot (HP:0001833)1.92503313
113Facial hemangioma (HP:0000329)1.91999043
114Cellular immunodeficiency (HP:0005374)1.90991535
115True hermaphroditism (HP:0010459)1.90625289
116Neoplasm of the small intestine (HP:0100833)1.90328721
117Oculomotor apraxia (HP:0000657)1.90007742
118Thyroid-stimulating hormone excess (HP:0002925)1.88837489
119Neoplasm of striated muscle (HP:0009728)1.88784003
120High pitched voice (HP:0001620)1.88650607
121Papillary thyroid carcinoma (HP:0002895)1.87302677
122Rectal prolapse (HP:0002035)1.86884577
123Tubulointerstitial nephritis (HP:0001970)1.86846350
124Sparse lateral eyebrow (HP:0005338)1.86131925
125Hypoplasia of the pons (HP:0012110)1.85834469
126Gastrointestinal carcinoma (HP:0002672)1.85591311
127Malignant gastrointestinal tract tumors (HP:0006749)1.85591311
128Abnormality of pyrimidine metabolism (HP:0004353)1.85464910
129Abnormality of the fingertips (HP:0001211)1.85203294
130Spinal muscular atrophy (HP:0007269)1.85103371
131Central scotoma (HP:0000603)1.84162109
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84096862
133Abnormal protein N-linked glycosylation (HP:0012347)1.84096862
134Abnormal protein glycosylation (HP:0012346)1.84096862
135Abnormal glycosylation (HP:0012345)1.84096862
136Postaxial foot polydactyly (HP:0001830)1.84077025
137Increased serum lactate (HP:0002151)1.83980757
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.83859342
139Cutaneous melanoma (HP:0012056)1.83780456
140Squamous cell carcinoma (HP:0002860)1.83644468
141Cutis marmorata (HP:0000965)1.83518820
142Vaginal atresia (HP:0000148)1.83085813
143Tracheoesophageal fistula (HP:0002575)1.82512856
144Overlapping toe (HP:0001845)1.82488054
145Lymphoma (HP:0002665)1.81985560
146Tongue fasciculations (HP:0001308)1.81793131
147Abnormality of the duodenum (HP:0002246)1.81631401
148Prominent metopic ridge (HP:0005487)1.80157729
149Optic nerve coloboma (HP:0000588)1.78864485
150Abnormality of the metopic suture (HP:0005556)1.78308467
151Pelvic girdle muscle weakness (HP:0003749)1.77940162
152Preauricular skin tag (HP:0000384)1.77859268
153Skin tags (HP:0010609)1.77822467
154Aplasia/Hypoplasia of the sternum (HP:0006714)1.77714993
155Abnormal hair whorl (HP:0010721)1.77483174
156Muscle fibrillation (HP:0010546)1.77154287
157Abnormal mitochondria in muscle tissue (HP:0008316)1.74346134
158Sclerocornea (HP:0000647)1.71032428
159Median cleft lip (HP:0000161)1.70299458
160Short tibia (HP:0005736)1.70015795
161Hip dysplasia (HP:0001385)1.68567213
162Acute necrotizing encephalopathy (HP:0006965)1.68279587
163Preaxial hand polydactyly (HP:0001177)1.67399740
164Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.66586311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.44389137
2BUB13.51441548
3MAP4K23.37440971
4WEE13.35825942
5TRIM283.24770826
6CDK122.99836761
7TSSK62.57088960
8EIF2AK12.43838057
9NEK12.40803385
10TTK2.37525537
11BCR2.37189375
12NEK22.33887153
13NUAK12.21506063
14EEF2K2.14063437
15TAOK32.06699725
16ERBB32.04655337
17ATR2.00244509
18ACVR1B1.89446666
19PLK11.88847312
20BRSK21.85119726
21RPS6KB21.82003753
22PASK1.79297488
23SRPK11.72393778
24CDK71.71946180
25PLK31.63397202
26MKNK11.59304642
27BRD41.58331133
28PLK41.53465188
29MARK31.51100437
30AURKB1.49224002
31STK101.48908727
32EIF2AK31.46542756
33FRK1.43258627
34CDK41.37067714
35WNK31.35414354
36MAP4K11.31713963
37LATS11.30935996
38CHEK11.30888823
39MAP3K81.30871766
40BMPR1B1.30499004
41PAK41.28878647
42NME11.28084493
43PDK41.27690165
44PDK31.27690165
45RPS6KA41.26242300
46DYRK31.25765119
47TGFBR11.23367558
48MELK1.23189891
49STK41.15692388
50BRSK11.14439153
51EPHA21.05861794
52TESK21.03361014
53SIK21.02499890
54CAMK1D1.01253779
55CHEK21.00510646
56ATM1.00059106
57FGFR40.97996416
58CDK60.94066433
59MAPK130.93852947
60TTN0.93649965
61NME20.92822846
62RAF10.92111946
63CDK20.90886288
64CHUK0.90108313
65AURKA0.89959449
66PKN20.87939997
67TEC0.87375381
68JAK30.86465979
69LRRK20.84673041
70MTOR0.84664191
71PBK0.83073200
72BCKDK0.82569646
73FER0.82032380
74MAP3K100.81741090
75SCYL20.80803375
76PIM10.80545898
77ZAK0.80438657
78NEK90.80276044
79STK30.79932878
80MST40.76885016
81TLK10.75764228
82ALK0.73110300
83CDK10.70465954
84PAK30.69995418
85VRK10.69695317
86ICK0.68411948
87INSRR0.64665730
88MAP2K70.64045184
89PTK60.63408342
90MST1R0.63128519
91PRKAA20.62981531
92PKN10.60762780
93CDK190.60601801
94STK160.60521656
95CSNK2A20.60414783
96FGFR10.59786198
97PLK20.59742041
98TNK20.55395289
99MAPK110.54430003
100ERBB20.53694366
101TAF10.53639058
102SIK10.53292311
103PDK20.53277301
104MKNK20.52641666
105ITK0.52433411
106CSNK1G10.51582293
107CDK30.50845469
108CSNK2A10.50234426
109FES0.49556204
110PAK10.48644021
111PRKD30.48625179
112EIF2AK20.47372353
113FGFR30.47212003
114CCNB10.47095033
115VRK20.47063127
116KSR10.46986354
117PIM20.46875451
118PRKCI0.46006756
119BTK0.44711234
120IRAK40.44682101
121CDK90.44048703
122MINK10.43141109
123PHKG10.42474328
124PHKG20.42474328
125YES10.41962132
126TYK20.41071270
127CSNK1A1L0.40915755
128PRKCQ0.40735422
129FLT30.39673785
130PNCK0.39377723
131PRKDC0.38735712
132FGFR20.38359449
133LMTK20.37518115
134AKT20.37393112
135CLK10.36996730
136KIT0.36709957
137PRKAA10.36360790
138CDK80.35380340
139KDR0.35124964
140TESK10.35048037
141PAK20.35006411
142FGR0.34240287
143RPS6KA50.34178778
144CAMK1G0.33740580
145SIK30.33303694
146HCK0.32899342
147CSNK1G30.31504917
148MAP3K40.29037219
149TXK0.28426755
150EGFR0.27464041
151NEK60.24430821
152CSNK1D0.21346932

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69417569
2Mismatch repair_Homo sapiens_hsa034303.94035531
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36056975
4RNA transport_Homo sapiens_hsa030133.07660710
5Base excision repair_Homo sapiens_hsa034103.01161785
6Cell cycle_Homo sapiens_hsa041102.92601801
7Spliceosome_Homo sapiens_hsa030402.92018378
8RNA polymerase_Homo sapiens_hsa030202.90306390
9One carbon pool by folate_Homo sapiens_hsa006702.83704854
10Homologous recombination_Homo sapiens_hsa034402.52687655
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46107596
12Nucleotide excision repair_Homo sapiens_hsa034202.44314655
13Proteasome_Homo sapiens_hsa030502.38828335
14Non-homologous end-joining_Homo sapiens_hsa034502.36287032
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17239560
16Pyrimidine metabolism_Homo sapiens_hsa002402.08656399
17Fanconi anemia pathway_Homo sapiens_hsa034601.85642583
18Protein export_Homo sapiens_hsa030601.83721341
19RNA degradation_Homo sapiens_hsa030181.67668761
20Ribosome_Homo sapiens_hsa030101.65351656
21mRNA surveillance pathway_Homo sapiens_hsa030151.63975740
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57069179
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57021344
24p53 signaling pathway_Homo sapiens_hsa041151.56695975
25Basal transcription factors_Homo sapiens_hsa030221.51837392
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47711578
27Antigen processing and presentation_Homo sapiens_hsa046121.32028838
28Epstein-Barr virus infection_Homo sapiens_hsa051691.29796394
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29095436
30Biosynthesis of amino acids_Homo sapiens_hsa012301.24726240
31Steroid biosynthesis_Homo sapiens_hsa001001.22426059
32Herpes simplex infection_Homo sapiens_hsa051681.21635898
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17499782
34Selenocompound metabolism_Homo sapiens_hsa004501.17443235
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.12016603
36Purine metabolism_Homo sapiens_hsa002301.11029080
37Regulation of autophagy_Homo sapiens_hsa041401.09221130
38Carbon metabolism_Homo sapiens_hsa012001.04806130
39Viral carcinogenesis_Homo sapiens_hsa052031.03844546
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96892589
41Huntingtons disease_Homo sapiens_hsa050160.95423348
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91574572
43Notch signaling pathway_Homo sapiens_hsa043300.91185496
44Parkinsons disease_Homo sapiens_hsa050120.90426058
45Thyroid cancer_Homo sapiens_hsa052160.89149855
46HTLV-I infection_Homo sapiens_hsa051660.87565658
47Butanoate metabolism_Homo sapiens_hsa006500.84166330
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82601677
49Pentose phosphate pathway_Homo sapiens_hsa000300.80784659
50Viral myocarditis_Homo sapiens_hsa054160.79772280
51Systemic lupus erythematosus_Homo sapiens_hsa053220.77174343
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76153354
53Oxidative phosphorylation_Homo sapiens_hsa001900.75655998
54Primary immunodeficiency_Homo sapiens_hsa053400.75433430
55MicroRNAs in cancer_Homo sapiens_hsa052060.75022042
56Oocyte meiosis_Homo sapiens_hsa041140.73770419
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.70400306
58Dorso-ventral axis formation_Homo sapiens_hsa043200.69613064
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68780402
60Small cell lung cancer_Homo sapiens_hsa052220.67713595
61Fatty acid elongation_Homo sapiens_hsa000620.66663711
62Vitamin B6 metabolism_Homo sapiens_hsa007500.65565701
63Legionellosis_Homo sapiens_hsa051340.63816192
64Folate biosynthesis_Homo sapiens_hsa007900.61877626
65Pyruvate metabolism_Homo sapiens_hsa006200.61542770
66TGF-beta signaling pathway_Homo sapiens_hsa043500.59069740
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58766586
68Colorectal cancer_Homo sapiens_hsa052100.58499303
69Caffeine metabolism_Homo sapiens_hsa002320.58416804
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58387448
71Adherens junction_Homo sapiens_hsa045200.57509248
72Peroxisome_Homo sapiens_hsa041460.56771884
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55653208
74Lysine degradation_Homo sapiens_hsa003100.54885648
75Hippo signaling pathway_Homo sapiens_hsa043900.54049806
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53725238
77Measles_Homo sapiens_hsa051620.53604698
78Apoptosis_Homo sapiens_hsa042100.52653312
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.52460619
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51062094
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50979477
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50904313
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49299348
84Chronic myeloid leukemia_Homo sapiens_hsa052200.48884709
85Metabolic pathways_Homo sapiens_hsa011000.48817323
86Influenza A_Homo sapiens_hsa051640.47428282
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46633319
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45600124
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45539892
90Hepatitis B_Homo sapiens_hsa051610.45236065
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44766080
92Basal cell carcinoma_Homo sapiens_hsa052170.42823017
93Fatty acid metabolism_Homo sapiens_hsa012120.40499293
94Propanoate metabolism_Homo sapiens_hsa006400.38785682
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.37793870
96Glutathione metabolism_Homo sapiens_hsa004800.37724878
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36160200
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.35085883
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34018942
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.32495410
101HIF-1 signaling pathway_Homo sapiens_hsa040660.32091234
102Acute myeloid leukemia_Homo sapiens_hsa052210.31975507
103Glycerolipid metabolism_Homo sapiens_hsa005610.31711784
104T cell receptor signaling pathway_Homo sapiens_hsa046600.31697776
105Pathways in cancer_Homo sapiens_hsa052000.30991560
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30184530
107Fatty acid degradation_Homo sapiens_hsa000710.29980059
108Pancreatic cancer_Homo sapiens_hsa052120.29222317
109mTOR signaling pathway_Homo sapiens_hsa041500.27771523
110Inositol phosphate metabolism_Homo sapiens_hsa005620.26629950
111N-Glycan biosynthesis_Homo sapiens_hsa005100.26071364
112Fructose and mannose metabolism_Homo sapiens_hsa000510.25223634
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24829634
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23259545
115Alcoholism_Homo sapiens_hsa050340.22717973
116beta-Alanine metabolism_Homo sapiens_hsa004100.22687817
117B cell receptor signaling pathway_Homo sapiens_hsa046620.22056456
118Prostate cancer_Homo sapiens_hsa052150.21395723
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20860946
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20584820
121Shigellosis_Homo sapiens_hsa051310.20420477
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.20059893
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19498968
124Toxoplasmosis_Homo sapiens_hsa051450.19165090
125Sulfur relay system_Homo sapiens_hsa041220.18569483
126Non-small cell lung cancer_Homo sapiens_hsa052230.18557259
127Endometrial cancer_Homo sapiens_hsa052130.17610397
128Allograft rejection_Homo sapiens_hsa053300.17339091
129Collecting duct acid secretion_Homo sapiens_hsa049660.16181590
130Alzheimers disease_Homo sapiens_hsa050100.12629359
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.10083236
132Tryptophan metabolism_Homo sapiens_hsa003800.08020766

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