INTS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.71448397
2nuclear pore organization (GO:0006999)4.49556763
3kinetochore organization (GO:0051383)4.35511554
4DNA unwinding involved in DNA replication (GO:0006268)4.26300173
5mitotic sister chromatid cohesion (GO:0007064)4.18478508
6mitotic metaphase plate congression (GO:0007080)4.05057894
7DNA replication initiation (GO:0006270)3.89953073
8pore complex assembly (GO:0046931)3.84399768
9kinetochore assembly (GO:0051382)3.83833427
10metaphase plate congression (GO:0051310)3.80110684
11non-recombinational repair (GO:0000726)3.68465095
12double-strand break repair via nonhomologous end joining (GO:0006303)3.68465095
13CENP-A containing nucleosome assembly (GO:0034080)3.67357859
14protein localization to kinetochore (GO:0034501)3.67232567
15chromatin remodeling at centromere (GO:0031055)3.61336898
16regulation of helicase activity (GO:0051095)3.59739299
17replication fork processing (GO:0031297)3.58687215
18positive regulation of chromosome segregation (GO:0051984)3.56972460
19sister chromatid segregation (GO:0000819)3.47680352
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39866215
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36252028
22DNA topological change (GO:0006265)3.35522925
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.34805350
24regulation of DNA endoreduplication (GO:0032875)3.34661509
25regulation of centriole replication (GO:0046599)3.34564018
26regulation of histone H3-K9 methylation (GO:0051570)3.34392854
27DNA replication-independent nucleosome organization (GO:0034724)3.32469338
28DNA replication-independent nucleosome assembly (GO:0006336)3.32469338
29meiotic chromosome segregation (GO:0045132)3.27117924
30microtubule depolymerization (GO:0007019)3.26248009
31mitotic sister chromatid segregation (GO:0000070)3.25201058
32DNA ligation (GO:0006266)3.24786139
33establishment of chromosome localization (GO:0051303)3.24134844
34protein K6-linked ubiquitination (GO:0085020)3.24049487
35DNA replication-dependent nucleosome assembly (GO:0006335)3.23674013
36DNA replication-dependent nucleosome organization (GO:0034723)3.23674013
37histone exchange (GO:0043486)3.20659900
38DNA replication checkpoint (GO:0000076)3.20585503
39IMP biosynthetic process (GO:0006188)3.19054214
40DNA duplex unwinding (GO:0032508)3.18119130
41DNA geometric change (GO:0032392)3.16347013
42resolution of meiotic recombination intermediates (GO:0000712)3.16132782
43DNA strand elongation involved in DNA replication (GO:0006271)3.14820889
44mitotic nuclear envelope disassembly (GO:0007077)3.14134348
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.13382657
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.11414433
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11414433
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11414433
49mitotic recombination (GO:0006312)3.10933378
50regulation of centrosome cycle (GO:0046605)3.09883126
51DNA double-strand break processing (GO:0000729)3.09751269
52spindle checkpoint (GO:0031577)3.09487792
53protein localization to chromosome, centromeric region (GO:0071459)3.09137479
54positive regulation of histone H3-K4 methylation (GO:0051571)3.07847832
55pre-miRNA processing (GO:0031054)3.07037256
56DNA strand elongation (GO:0022616)3.04697254
57establishment of integrated proviral latency (GO:0075713)3.04034722
58histone H3-K9 methylation (GO:0051567)3.03709819
59regulation of sister chromatid cohesion (GO:0007063)2.97215943
60regulation of RNA export from nucleus (GO:0046831)2.94668383
61regulation of centrosome duplication (GO:0010824)2.93917031
62regulation of chromosome segregation (GO:0051983)2.93867268
63telomere maintenance via semi-conservative replication (GO:0032201)2.92812995
64monoubiquitinated protein deubiquitination (GO:0035520)2.91969847
65mitotic spindle checkpoint (GO:0071174)2.91812440
66regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91646806
67mitotic chromosome condensation (GO:0007076)2.89909728
68attachment of spindle microtubules to kinetochore (GO:0008608)2.89568529
69nuclear envelope disassembly (GO:0051081)2.88710899
70membrane disassembly (GO:0030397)2.88710899
71regulation of spindle organization (GO:0090224)2.87642232
72spindle assembly checkpoint (GO:0071173)2.86218134
73microtubule polymerization or depolymerization (GO:0031109)2.84998657
74cytoplasmic mRNA processing body assembly (GO:0033962)2.84305325
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84128202
76nucleobase biosynthetic process (GO:0046112)2.83404068
77regulation of sister chromatid segregation (GO:0033045)2.82775926
78regulation of mitotic sister chromatid separation (GO:0010965)2.82775926
79regulation of mitotic sister chromatid segregation (GO:0033047)2.82775926
80ATP-dependent chromatin remodeling (GO:0043044)2.82515070
81negative regulation of chromosome segregation (GO:0051985)2.82007333
82regulation of DNA damage checkpoint (GO:2000001)2.81564415
83nucleotide-excision repair, DNA gap filling (GO:0006297)2.81507842
84negative regulation of mitotic sister chromatid separation (GO:2000816)2.81413647
85negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81413647
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81413647
87negative regulation of sister chromatid segregation (GO:0033046)2.81413647
88telomere maintenance via recombination (GO:0000722)2.80992857
89negative regulation of mRNA processing (GO:0050686)2.80585395
90chromatin assembly or disassembly (GO:0006333)2.80500054
91mRNA splice site selection (GO:0006376)2.80251663
92negative regulation of mRNA metabolic process (GO:1903312)2.80024228
93mitotic G2/M transition checkpoint (GO:0044818)2.79788371
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.78876191
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78876191
96mitotic spindle assembly checkpoint (GO:0007094)2.77784945
97double-strand break repair via homologous recombination (GO:0000724)2.76181094
98response to UV-C (GO:0010225)2.75206487
99mRNA cleavage (GO:0006379)2.75008728
100chromosome segregation (GO:0007059)2.73303675
101recombinational repair (GO:0000725)2.73101523
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72183692
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71984664
104sister chromatid cohesion (GO:0007062)2.71812813
105regulation of establishment of cell polarity (GO:2000114)2.71777063
106tRNA methylation (GO:0030488)2.71776064
107mitotic spindle organization (GO:0007052)2.71729542
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71221501
109positive regulation of histone methylation (GO:0031062)2.70630005
110protein localization to chromosome (GO:0034502)2.69491555
111regulation of sarcomere organization (GO:0060297)2.69140648
112mismatch repair (GO:0006298)2.68086360
113centriole replication (GO:0007099)2.68049718
114chromatin assembly (GO:0031497)2.67835366
115RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67044953
116negative regulation of DNA repair (GO:0045738)2.65469049
117spindle assembly involved in mitosis (GO:0090307)2.65102451
118peptidyl-threonine dephosphorylation (GO:0035970)2.65010467
119telomere maintenance via telomere lengthening (GO:0010833)2.62451507
120ribosome assembly (GO:0042255)2.62435222
121DNA conformation change (GO:0071103)2.60838882
122negative regulation of histone methylation (GO:0031061)2.59476470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.56752544
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.55907284
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42698730
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46531099
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.20442418
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17662962
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05433937
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.03041500
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79028901
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75845567
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47809731
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.46433295
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.26415497
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26153318
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20327864
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15685589
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.14556355
18ELK1_19687146_ChIP-ChIP_HELA_Human2.10653435
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07442802
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07116020
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06227400
22* FUS_26573619_Chip-Seq_HEK293_Human2.01062862
23AR_21909140_ChIP-Seq_LNCAP_Human1.94467808
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91180828
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.84383400
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83488097
27TAF15_26573619_Chip-Seq_HEK293_Human1.83325911
28IGF1R_20145208_ChIP-Seq_DFB_Human1.81906831
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80317764
30EWS_26573619_Chip-Seq_HEK293_Human1.78906563
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78445691
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75059870
33ZNF274_21170338_ChIP-Seq_K562_Hela1.70607866
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69759911
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65379482
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57714793
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56482891
38VDR_23849224_ChIP-Seq_CD4+_Human1.55274342
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54903005
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.53294450
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.52108177
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51087150
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47938079
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47938079
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47938079
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45708960
47VDR_22108803_ChIP-Seq_LS180_Human1.44078760
48FOXP3_21729870_ChIP-Seq_TREG_Human1.42403790
49ER_23166858_ChIP-Seq_MCF-7_Human1.41694753
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40766453
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37366613
52GBX2_23144817_ChIP-Seq_PC3_Human1.33070928
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31393966
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31090295
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.28977237
56TTF2_22483619_ChIP-Seq_HELA_Human1.28912716
57* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28086589
58XRN2_22483619_ChIP-Seq_HELA_Human1.26960809
59* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25308772
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23887520
61P300_19829295_ChIP-Seq_ESCs_Human1.23289604
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22074071
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21551949
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20876827
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19068662
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.18623818
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15760805
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15266744
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15221228
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14660885
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14433163
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14229541
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13869513
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13725800
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13674602
76* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12977760
77* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12966622
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10098812
79MYC_18940864_ChIP-ChIP_HL60_Human1.09637272
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08477088
81* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07575659
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07091755
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04772958
84* DCP1A_22483619_ChIP-Seq_HELA_Human1.02078593
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01216367
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00973594
87STAT3_23295773_ChIP-Seq_U87_Human1.00597822
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.97556337
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96546565
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94650314
91KDM5A_27292631_Chip-Seq_BREAST_Human0.93903098
92SMAD4_21799915_ChIP-Seq_A2780_Human0.93378997
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93336466
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93274910
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.93220770
96CIITA_25753668_ChIP-Seq_RAJI_Human0.93030187
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.91186538
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91120608
99TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90440121
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.88887329
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88794464
102KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87864003
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87113637
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87066037
105CBP_20019798_ChIP-Seq_JUKART_Human0.87066037
106* IRF1_19129219_ChIP-ChIP_H3396_Human0.86631267
107TCF4_23295773_ChIP-Seq_U87_Human0.85947292
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.85823574
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85016416
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84256761
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83700344
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83067682
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82438645
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82356320
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.82033249
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81496351
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81086981
118EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80973729
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79607702
120* GABP_19822575_ChIP-Seq_HepG2_Human0.77726156
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77343836
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.76347197
123SOX9_26525672_Chip-Seq_HEART_Mouse0.75353104
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.75280872
125* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74993520
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74557148
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.73168799
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.72494530
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72452167
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71548515
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71115225
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.69856120
133TFEB_21752829_ChIP-Seq_HELA_Human0.69731814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.35512048
2MP0010094_abnormal_chromosome_stability3.68797188
3MP0003693_abnormal_embryo_hatching3.32252379
4MP0003111_abnormal_nucleus_morphology3.32012553
5MP0003077_abnormal_cell_cycle2.92482408
6MP0008058_abnormal_DNA_repair2.85387961
7MP0004957_abnormal_blastocyst_morpholog2.81995473
8MP0003121_genomic_imprinting2.49390607
9MP0008877_abnormal_DNA_methylation2.41075477
10MP0008932_abnormal_embryonic_tissue2.22021693
11MP0008007_abnormal_cellular_replicative2.20516939
12MP0003123_paternal_imprinting2.10346300
13MP0006292_abnormal_olfactory_placode2.04860034
14MP0003787_abnormal_imprinting2.03492090
15MP0003937_abnormal_limbs/digits/tail_de1.95960095
16MP0010234_abnormal_vibrissa_follicle1.92067421
17MP0003136_yellow_coat_color1.91107035
18MP0009697_abnormal_copulation1.90597277
19MP0005171_absent_coat_pigmentation1.88173028
20MP0000566_synostosis1.84914375
21MP0003890_abnormal_embryonic-extraembry1.80433904
22MP0002102_abnormal_ear_morphology1.78739568
23MP0001293_anophthalmia1.75424752
24MP0003221_abnormal_cardiomyocyte_apopto1.70234538
25MP0003786_premature_aging1.63610729
26MP0010307_abnormal_tumor_latency1.60260809
27MP0000350_abnormal_cell_proliferation1.59533995
28MP0001188_hyperpigmentation1.58419022
29MP0002938_white_spotting1.55770699
30MP0001730_embryonic_growth_arrest1.46406222
31MP0002396_abnormal_hematopoietic_system1.43581149
32MP0002085_abnormal_embryonic_tissue1.43398268
33MP0000569_abnormal_digit_pigmentation1.43301424
34MP0002084_abnormal_developmental_patter1.42292078
35MP0004264_abnormal_extraembryonic_tissu1.39912277
36MP0001672_abnormal_embryogenesis/_devel1.35062517
37MP0005380_embryogenesis_phenotype1.35062517
38MP0006072_abnormal_retinal_apoptosis1.33804996
39MP0000427_abnormal_hair_cycle1.30173324
40MP0009672_abnormal_birth_weight1.29831612
41MP0004197_abnormal_fetal_growth/weight/1.29724544
42MP0002234_abnormal_pharynx_morphology1.28551475
43MP0003943_abnormal_hepatobiliary_system1.27224934
44MP0000383_abnormal_hair_follicle1.26698779
45MP0003755_abnormal_palate_morphology1.26472324
46MP0005187_abnormal_penis_morphology1.25088109
47MP0001697_abnormal_embryo_size1.22531973
48MP0000647_abnormal_sebaceous_gland1.19985183
49MP0000516_abnormal_urinary_system1.19637734
50MP0005367_renal/urinary_system_phenotyp1.19637734
51MP0003938_abnormal_ear_development1.19177747
52MP0005408_hypopigmentation1.18471972
53MP0005409_darkened_coat_color1.17402676
54MP0001485_abnormal_pinna_reflex1.15858989
55MP0002009_preneoplasia1.15649112
56MP0001286_abnormal_eye_development1.14582847
57MP0003941_abnormal_skin_development1.12912455
58MP0000049_abnormal_middle_ear1.12572697
59MP0000537_abnormal_urethra_morphology1.12361723
60MP0000432_abnormal_head_morphology1.11817420
61MP0004233_abnormal_muscle_weight1.11745475
62MP0002233_abnormal_nose_morphology1.11631969
63MP0003122_maternal_imprinting1.10826017
64MP0003935_abnormal_craniofacial_develop1.10557972
65MP0000372_irregular_coat_pigmentation1.09398933
66MP0003984_embryonic_growth_retardation1.08961555
67MP0002751_abnormal_autonomic_nervous1.08748324
68MP0002210_abnormal_sex_determination1.08111550
69MP0003861_abnormal_nervous_system1.07470655
70MP0004133_heterotaxia1.06179864
71MP0002088_abnormal_embryonic_growth/wei1.05909907
72MP0005174_abnormal_tail_pigmentation1.04721819
73MP0003950_abnormal_plasma_membrane1.02959382
74MP0009703_decreased_birth_body1.02956220
75MP0002080_prenatal_lethality1.01150597
76MP0008789_abnormal_olfactory_epithelium1.00921412
77MP0002086_abnormal_extraembryonic_tissu1.00580472
78MP0003315_abnormal_perineum_morphology0.99353671
79MP0005076_abnormal_cell_differentiation0.99172574
80MP0000015_abnormal_ear_pigmentation0.98925942
81MP0010678_abnormal_skin_adnexa0.98724545
82MP0005075_abnormal_melanosome_morpholog0.98112758
83MP0002697_abnormal_eye_size0.96823384
84MP0003567_abnormal_fetal_cardiomyocyte0.96611315
85MP0002177_abnormal_outer_ear0.96194730
86MP0001145_abnormal_male_reproductive0.94510866
87MP0003718_maternal_effect0.94502636
88MP0001299_abnormal_eye_distance/0.94296100
89MP0002111_abnormal_tail_morphology0.93006525
90MP0003119_abnormal_digestive_system0.92652052
91MP0000358_abnormal_cell_content/0.92430225
92MP0002116_abnormal_craniofacial_bone0.92393131
93MP0006035_abnormal_mitochondrial_morpho0.91979847
94MP0002114_abnormal_axial_skeleton0.91468403
95MP0005248_abnormal_Harderian_gland0.91375794
96MP0002098_abnormal_vibrissa_morphology0.90763967
97MP0009250_abnormal_appendicular_skeleto0.89257462
98MP0000428_abnormal_craniofacial_morphol0.89069746
99MP0003385_abnormal_body_wall0.89035337
100MP0001529_abnormal_vocalization0.88336690
101MP0000490_abnormal_crypts_of0.87642974
102MP0002095_abnormal_skin_pigmentation0.87287076
103MP0010030_abnormal_orbit_morphology0.87017226
104MP0000313_abnormal_cell_death0.86402475
105MP0004885_abnormal_endolymph0.86028222
106MP0009780_abnormal_chondrocyte_physiolo0.85294546
107MP0002092_abnormal_eye_morphology0.85256008
108MP0002160_abnormal_reproductive_system0.85238212
109MP0002163_abnormal_gland_morphology0.83548507
110MP0000778_abnormal_nervous_system0.83094435
111MP0001929_abnormal_gametogenesis0.82290699
112MP0002249_abnormal_larynx_morphology0.80595326
113MP0003936_abnormal_reproductive_system0.80507883
114MP0005391_vision/eye_phenotype0.80430989
115MP0000631_abnormal_neuroendocrine_gland0.80394520
116MP0010352_gastrointestinal_tract_polyps0.79008240
117MP0002877_abnormal_melanocyte_morpholog0.78913610
118MP0000653_abnormal_sex_gland0.78753675
119MP0005394_taste/olfaction_phenotype0.78171212
120MP0005499_abnormal_olfactory_system0.78171212
121MP0005623_abnormal_meninges_morphology0.76643407
122MP0005253_abnormal_eye_physiology0.76490419
123MP0004134_abnormal_chest_morphology0.74980749
124MP0003195_calcinosis0.74895049
125MP0003698_abnormal_male_reproductive0.73580825
126MP0000762_abnormal_tongue_morphology0.72228926
127MP0002109_abnormal_limb_morphology0.72195225
128MP0000462_abnormal_digestive_system0.72075634
129MP0001119_abnormal_female_reproductive0.71103744
130MP0001348_abnormal_lacrimal_gland0.67482082
131MP0001346_abnormal_lacrimal_gland0.66609770
132MP0002081_perinatal_lethality0.65559689
133MP0000371_diluted_coat_color0.64812713
134MP0002184_abnormal_innervation0.64572560

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29517343
2Chromsome breakage (HP:0040012)4.29104307
3Birth length less than 3rd percentile (HP:0003561)3.51108407
4Medulloblastoma (HP:0002885)3.33529191
5Volvulus (HP:0002580)3.25560771
6Ectopic kidney (HP:0000086)3.08080626
7Abnormality of the labia minora (HP:0012880)3.06566961
8Papillary thyroid carcinoma (HP:0002895)2.94511817
9Neoplasm of the adrenal cortex (HP:0100641)2.82637421
10Abnormality of chromosome stability (HP:0003220)2.78430758
11Nephroblastoma (Wilms tumor) (HP:0002667)2.77802274
12Duplicated collecting system (HP:0000081)2.73173462
13Embryonal renal neoplasm (HP:0011794)2.64954848
14Hyperventilation (HP:0002883)2.64602607
15Absent radius (HP:0003974)2.62940172
16Supernumerary spleens (HP:0009799)2.61841589
17Meckel diverticulum (HP:0002245)2.60074730
18Absent forearm bone (HP:0003953)2.56812608
19Aplasia involving forearm bones (HP:0009822)2.56812608
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53047398
21Short 4th metacarpal (HP:0010044)2.53047398
22Abnormality of the renal collecting system (HP:0004742)2.52355745
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.45331744
24Abnormality of the ileum (HP:0001549)2.44889222
25Curly hair (HP:0002212)2.40900274
26Thyroid carcinoma (HP:0002890)2.36236265
27Abnormal lung lobation (HP:0002101)2.35415701
28Abnormality of the preputium (HP:0100587)2.33177971
29Breast carcinoma (HP:0003002)2.32681641
30Patellar aplasia (HP:0006443)2.29637728
31Abnormality of cochlea (HP:0000375)2.29447150
32Breast hypoplasia (HP:0003187)2.29285415
33Neoplasm of the oral cavity (HP:0100649)2.26256472
34Ependymoma (HP:0002888)2.23985573
35Reticulocytopenia (HP:0001896)2.20769814
36Impulsivity (HP:0100710)2.19637697
37Cafe-au-lait spot (HP:0000957)2.17310341
38Small intestinal stenosis (HP:0012848)2.15520540
39Duodenal stenosis (HP:0100867)2.15520540
40Morphological abnormality of the inner ear (HP:0011390)2.14860576
41Aplasia/Hypoplasia of the patella (HP:0006498)2.13541502
42Pancreatic islet-cell hyperplasia (HP:0004510)2.13009641
43Cystic hygroma (HP:0000476)2.12454685
44Clubbing of toes (HP:0100760)2.08966360
45Transitional cell carcinoma of the bladder (HP:0006740)2.08609231
46Supernumerary bones of the axial skeleton (HP:0009144)2.08494633
47Short thumb (HP:0009778)2.06913006
48Asplenia (HP:0001746)2.05855038
49Facial hemangioma (HP:0000329)2.05258986
50Supernumerary ribs (HP:0005815)2.05101730
51Agnosia (HP:0010524)2.03893990
52Neoplasm of the adrenal gland (HP:0100631)2.03678564
53Abnormal number of incisors (HP:0011064)2.03541704
54Embryonal neoplasm (HP:0002898)2.01161566
55Intestinal atresia (HP:0011100)2.00202552
56Rhabdomyosarcoma (HP:0002859)2.00143599
57Increased nuchal translucency (HP:0010880)1.99230469
58Leiomyosarcoma (HP:0100243)1.98795536
59Uterine leiomyosarcoma (HP:0002891)1.98795536
60Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98662410
61Septo-optic dysplasia (HP:0100842)1.98393006
62Malignant gastrointestinal tract tumors (HP:0006749)1.95535556
63Gastrointestinal carcinoma (HP:0002672)1.95535556
64Lissencephaly (HP:0001339)1.93892512
65Bladder carcinoma (HP:0002862)1.93803278
66Bladder neoplasm (HP:0009725)1.93803278
67Myelodysplasia (HP:0002863)1.92851609
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.92638175
69High anterior hairline (HP:0009890)1.92498323
70Glioma (HP:0009733)1.92140951
71Oligodactyly (hands) (HP:0001180)1.91777408
72Hypopigmentation of the fundus (HP:0007894)1.91694966
73Bifid tongue (HP:0010297)1.91424150
74Abnormality of the carotid arteries (HP:0005344)1.90528298
75Sloping forehead (HP:0000340)1.89854054
76Rib fusion (HP:0000902)1.89019847
77Proximal placement of thumb (HP:0009623)1.88560635
78Absent eyebrow (HP:0002223)1.86296974
79Abnormality of chromosome segregation (HP:0002916)1.84164399
80Esophageal atresia (HP:0002032)1.84059524
81Abnormality of the duodenum (HP:0002246)1.83994581
82Colon cancer (HP:0003003)1.83978722
83Abdominal situs inversus (HP:0003363)1.83974077
84Abnormality of abdominal situs (HP:0011620)1.83974077
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.82695298
86Hypoplastic pelvis (HP:0008839)1.82576275
87Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82129485
88Broad alveolar ridges (HP:0000187)1.81986987
89Abnormality of the parietal bone (HP:0002696)1.81437612
90Abnormality of the astrocytes (HP:0100707)1.80956687
91Astrocytoma (HP:0009592)1.80956687
92Gastrointestinal atresia (HP:0002589)1.80856707
93Renal cortical cysts (HP:0000803)1.80843790
9411 pairs of ribs (HP:0000878)1.80471942
95Deviation of the thumb (HP:0009603)1.80458306
96Abnormality of the antihelix (HP:0009738)1.79602217
97Neoplasm of the colon (HP:0100273)1.79376707
98Atresia of the external auditory canal (HP:0000413)1.78492316
99Preaxial hand polydactyly (HP:0001177)1.78430419
100Uterine neoplasm (HP:0010784)1.77382881
101Asymmetry of the thorax (HP:0001555)1.76654698
102Progressive inability to walk (HP:0002505)1.76240112
103Abnormality of DNA repair (HP:0003254)1.76062291
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73657319
105Pancreatic cysts (HP:0001737)1.73541187
106Oligodactyly (HP:0012165)1.73259899
107Short middle phalanx of the 5th finger (HP:0004220)1.73240727
108Abnormality of the incisor (HP:0000676)1.72681377
109Limb hypertonia (HP:0002509)1.72104208
110Premature graying of hair (HP:0002216)1.72033402
111Neoplasm of striated muscle (HP:0009728)1.71504533
112Skull defect (HP:0001362)1.71178611
113Microtia (HP:0008551)1.70298724
114Duplication of thumb phalanx (HP:0009942)1.70030870
115Triphalangeal thumb (HP:0001199)1.69523857
116Cortical dysplasia (HP:0002539)1.69344950
117Spinal muscular atrophy (HP:0007269)1.69157981
118Choanal atresia (HP:0000453)1.68749902
119Microvesicular hepatic steatosis (HP:0001414)1.68141699
120Abnormality of glycolysis (HP:0004366)1.68053996
121Long clavicles (HP:0000890)1.67916579
122Progressive external ophthalmoplegia (HP:0000590)1.67268892
123Abnormality of the anterior horn cell (HP:0006802)1.67004318
124Degeneration of anterior horn cells (HP:0002398)1.67004318
125Anal stenosis (HP:0002025)1.66994153
126Cutaneous melanoma (HP:0012056)1.66461311
127Increased serum pyruvate (HP:0003542)1.65393915
128Anophthalmia (HP:0000528)1.65359512
129Hip dysplasia (HP:0001385)1.64570286
130Arteriovenous malformation (HP:0100026)1.63712880
131Astigmatism (HP:0000483)1.63641791
132Hepatoblastoma (HP:0002884)1.63379558
133Cupped ear (HP:0000378)1.63174179
134Bone marrow hypocellularity (HP:0005528)1.62554570
135Facial cleft (HP:0002006)1.62351630
136Sandal gap (HP:0001852)1.61629004
137Abnormality of the nasal septum (HP:0000419)1.60849935
138Abnormality of the parathyroid morphology (HP:0011766)1.60721930
139Horseshoe kidney (HP:0000085)1.60011348
140Hemivertebrae (HP:0002937)1.59450004
141Overlapping toe (HP:0001845)1.58944276
142Missing ribs (HP:0000921)1.58925884
143Microglossia (HP:0000171)1.58753573
144Neoplasm of the thyroid gland (HP:0100031)1.57991066
145Biliary tract neoplasm (HP:0100574)1.57628843
146Selective tooth agenesis (HP:0001592)1.57427907
147Abnormal biliary tract morphology (HP:0012440)1.57279681
148Postnatal growth retardation (HP:0008897)1.56419511
149Abnormality of methionine metabolism (HP:0010901)1.56134102
150Deep philtrum (HP:0002002)1.55379627
151Obsessive-compulsive behavior (HP:0000722)1.55111755
152Absent thumb (HP:0009777)1.55046437
153Aplasia/hypoplasia of the humerus (HP:0006507)1.53180921
154Small hand (HP:0200055)1.53021324
155Abnormal foot bone ossification (HP:0010675)1.52290968
156Decreased lacrimation (HP:0000633)1.52189038
157White forelock (HP:0002211)1.51987909
158Abnormality of the 4th metacarpal (HP:0010012)1.51682323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.21018832
2SRPK13.60248616
3MKNK13.42962594
4MKNK23.11451549
5BUB12.80541783
6WEE12.66328008
7CDK122.50986475
8TAF12.47813343
9PNCK2.33831175
10STK38L2.24354923
11TRIM282.17754177
12SCYL22.03348758
13TTK2.02585267
14EIF2AK12.00399078
15BRD41.99088678
16PLK31.98285088
17ZAK1.91908081
18TSSK61.91441846
19STK161.88560852
20PLK41.82535871
21ATR1.81161928
22TNIK1.80536498
23NEK21.79684652
24CHEK21.72183284
25PLK11.67766141
26MST41.62504979
27PASK1.56799662
28EIF2AK31.55342151
29CDK71.54934781
30VRK11.48704901
31EIF2AK21.46259278
32MAP4K21.44713813
33CHEK11.42865539
34TLK11.36202044
35AURKB1.34847441
36ERBB31.30659656
37LATS11.28826170
38ATM1.28091202
39RPS6KB21.27228487
40MAP3K91.26305679
41NEK11.20854619
42BRSK21.20731071
43NUAK11.20218025
44BCR1.19843695
45NEK61.14303492
46CLK11.14292036
47MAP3K41.13896718
48DYRK31.11357265
49STK391.06064684
50YES11.05411170
51AKT31.04435486
52CDK81.03473214
53STK41.01573042
54CSNK1A1L0.98375279
55CDK10.97430719
56BMPR1B0.97275918
57ERBB40.93752615
58CDK20.92554114
59PIK3CA0.88622933
60PBK0.87776670
61CASK0.85663646
62PKN20.83786628
63ALK0.83017860
64MELK0.82582658
65STK30.82540268
66MAP3K100.81514224
67AURKA0.79017225
68EPHA20.77999852
69EEF2K0.76401256
70PLK20.75898193
71MAPK130.75893584
72RPS6KA50.75498914
73TGFBR10.75471479
74CSNK1G30.72145772
75CDK40.72101773
76WNK40.71838352
77KSR10.71771616
78MARK10.71678497
79CDK60.71348490
80STK100.69242223
81CSNK1G10.67906172
82CSNK1D0.66997414
83PIM10.66875102
84CSNK2A20.66035111
85VRK20.66024150
86MAP3K80.65362585
87RPS6KA40.65215693
88OXSR10.62797067
89MST1R0.62666853
90CSNK1E0.62584488
91PRKDC0.60739256
92MET0.58915655
93ACVR1B0.57158872
94FRK0.56358460
95MAPK140.55798695
96CAMK1G0.54748134
97FGFR20.53206713
98CDK90.52902434
99CDK30.52712916
100RPS6KB10.50787184
101WNK10.50541137
102FER0.50279679
103ICK0.50249721
104FGR0.49828834
105GSK3B0.49450668
106CSNK2A10.48873563
107FGFR10.46478044
108PRKCI0.46172978
109WNK30.45523093
110BRSK10.44082339
111PRPF4B0.38608673
112BMPR20.35350771
113SIK30.34636883
114MTOR0.34631252
115AKT10.33873420
116IRAK40.33098762
117CSNK1G20.33073834
118MAPK100.32889846
119AKT20.32215126
120MAPKAPK50.31973700
121UHMK10.31926171
122MARK30.29762435
123PRKACB0.29649311
124NEK90.29372991
125CCNB10.29182395
126MAPK10.27842845
127DYRK1A0.27475428

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.59423963
2DNA replication_Homo sapiens_hsa030303.53241374
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37818008
4Homologous recombination_Homo sapiens_hsa034403.00473811
5Spliceosome_Homo sapiens_hsa030402.96418505
6Fanconi anemia pathway_Homo sapiens_hsa034602.92322958
7RNA transport_Homo sapiens_hsa030132.76497832
8RNA polymerase_Homo sapiens_hsa030202.72188731
9Cell cycle_Homo sapiens_hsa041102.71934218
10Non-homologous end-joining_Homo sapiens_hsa034502.71626570
11Nucleotide excision repair_Homo sapiens_hsa034202.51720312
12Basal transcription factors_Homo sapiens_hsa030222.27367766
13mRNA surveillance pathway_Homo sapiens_hsa030152.20673104
14Base excision repair_Homo sapiens_hsa034102.16825537
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16701203
16One carbon pool by folate_Homo sapiens_hsa006702.05221720
17RNA degradation_Homo sapiens_hsa030181.99154380
18Propanoate metabolism_Homo sapiens_hsa006401.99109755
19Systemic lupus erythematosus_Homo sapiens_hsa053221.80688234
20Proteasome_Homo sapiens_hsa030501.58829370
21Pyrimidine metabolism_Homo sapiens_hsa002401.58388598
22Ribosome_Homo sapiens_hsa030101.51251486
23p53 signaling pathway_Homo sapiens_hsa041151.42455993
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33429388
25Selenocompound metabolism_Homo sapiens_hsa004501.33229933
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.31848851
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25638549
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23475924
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23444296
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18985270
31MicroRNAs in cancer_Homo sapiens_hsa052061.18275515
32Basal cell carcinoma_Homo sapiens_hsa052171.17751546
33Alcoholism_Homo sapiens_hsa050341.16893940
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16705287
35Viral carcinogenesis_Homo sapiens_hsa052031.16076321
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13884184
37Oocyte meiosis_Homo sapiens_hsa041141.12348778
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12252435
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12106326
40Purine metabolism_Homo sapiens_hsa002301.07271923
41Epstein-Barr virus infection_Homo sapiens_hsa051691.02748020
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98264694
43TGF-beta signaling pathway_Homo sapiens_hsa043500.93218740
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92526499
45Protein export_Homo sapiens_hsa030600.91562273
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91359210
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91268956
48Pyruvate metabolism_Homo sapiens_hsa006200.89950750
49Hedgehog signaling pathway_Homo sapiens_hsa043400.88847597
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85773528
51Hippo signaling pathway_Homo sapiens_hsa043900.85708454
52Herpes simplex infection_Homo sapiens_hsa051680.85068528
53Phototransduction_Homo sapiens_hsa047440.81913616
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81795846
55Wnt signaling pathway_Homo sapiens_hsa043100.77611771
56Prostate cancer_Homo sapiens_hsa052150.75959416
57Butanoate metabolism_Homo sapiens_hsa006500.75035077
58Ether lipid metabolism_Homo sapiens_hsa005650.73050502
59HTLV-I infection_Homo sapiens_hsa051660.72710323
60Small cell lung cancer_Homo sapiens_hsa052220.72132363
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70720104
62Axon guidance_Homo sapiens_hsa043600.67090602
63Fatty acid biosynthesis_Homo sapiens_hsa000610.66884103
64Biosynthesis of amino acids_Homo sapiens_hsa012300.66354418
65Adherens junction_Homo sapiens_hsa045200.63815889
66Colorectal cancer_Homo sapiens_hsa052100.63644382
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62426219
68Antigen processing and presentation_Homo sapiens_hsa046120.58047693
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55976050
70Melanoma_Homo sapiens_hsa052180.55777134
71Carbon metabolism_Homo sapiens_hsa012000.55432882
72Pathways in cancer_Homo sapiens_hsa052000.55086551
73Notch signaling pathway_Homo sapiens_hsa043300.52207829
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52127811
75Sphingolipid metabolism_Homo sapiens_hsa006000.52022246
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.51156154
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50934638
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50554075
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50294101
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49372469
81Fatty acid metabolism_Homo sapiens_hsa012120.49351245
82Autoimmune thyroid disease_Homo sapiens_hsa053200.46551398
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46413454
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46042500
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.45062268
86Lysine degradation_Homo sapiens_hsa003100.44654819
87Tight junction_Homo sapiens_hsa045300.44635879
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44089826
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43494863
90Fatty acid degradation_Homo sapiens_hsa000710.42348784
91Arachidonic acid metabolism_Homo sapiens_hsa005900.41653792
92Nitrogen metabolism_Homo sapiens_hsa009100.40476371
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40435465
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38623629
95Primary immunodeficiency_Homo sapiens_hsa053400.38564168
96Measles_Homo sapiens_hsa051620.37096735
97ECM-receptor interaction_Homo sapiens_hsa045120.36127710
98Olfactory transduction_Homo sapiens_hsa047400.35493190
99Nicotine addiction_Homo sapiens_hsa050330.35271748
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34740181
101mTOR signaling pathway_Homo sapiens_hsa041500.34639724
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33532618
103Thyroid cancer_Homo sapiens_hsa052160.31352870
104Circadian rhythm_Homo sapiens_hsa047100.31143372
105Vitamin B6 metabolism_Homo sapiens_hsa007500.30938937
106Proteoglycans in cancer_Homo sapiens_hsa052050.30030027
107Dorso-ventral axis formation_Homo sapiens_hsa043200.29956574
108Steroid biosynthesis_Homo sapiens_hsa001000.29441872
109FoxO signaling pathway_Homo sapiens_hsa040680.29234068
110Hepatitis B_Homo sapiens_hsa051610.29195085
111Viral myocarditis_Homo sapiens_hsa054160.28979426
112Endometrial cancer_Homo sapiens_hsa052130.28492895
113Tryptophan metabolism_Homo sapiens_hsa003800.27371213
114Serotonergic synapse_Homo sapiens_hsa047260.26441079
115Glioma_Homo sapiens_hsa052140.25840893
116Linoleic acid metabolism_Homo sapiens_hsa005910.25751665
117T cell receptor signaling pathway_Homo sapiens_hsa046600.25067782
118Ras signaling pathway_Homo sapiens_hsa040140.24845110
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24819906
120Hematopoietic cell lineage_Homo sapiens_hsa046400.24732880
121Apoptosis_Homo sapiens_hsa042100.23692791
122Chronic myeloid leukemia_Homo sapiens_hsa052200.23285559
123N-Glycan biosynthesis_Homo sapiens_hsa005100.23161373
124Focal adhesion_Homo sapiens_hsa045100.22968012
125Choline metabolism in cancer_Homo sapiens_hsa052310.22842102
126Metabolic pathways_Homo sapiens_hsa011000.22822348
127ABC transporters_Homo sapiens_hsa020100.22448213
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21786875
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21353016
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20963145
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20919075
132ErbB signaling pathway_Homo sapiens_hsa040120.20887350
133Renal cell carcinoma_Homo sapiens_hsa052110.20459925
134Taste transduction_Homo sapiens_hsa047420.20409028
135Inositol phosphate metabolism_Homo sapiens_hsa005620.20314282
136Melanogenesis_Homo sapiens_hsa049160.19513208
137MAPK signaling pathway_Homo sapiens_hsa040100.19131943
138Allograft rejection_Homo sapiens_hsa053300.18633440
139Non-small cell lung cancer_Homo sapiens_hsa052230.16898103

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