INSM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)8.33155271
2phenol-containing compound catabolic process (GO:0019336)7.70739170
3pyrimidine nucleobase catabolic process (GO:0006208)7.40922910
4behavioral response to nicotine (GO:0035095)6.97639726
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.77987995
6sympathetic nervous system development (GO:0048485)6.50947641
7nucleobase catabolic process (GO:0046113)5.78855569
8detection of temperature stimulus involved in sensory perception (GO:0050961)5.53894146
9detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.53894146
10axonal fasciculation (GO:0007413)5.42170821
11dendritic spine morphogenesis (GO:0060997)5.25276605
12olfactory bulb development (GO:0021772)5.15402566
13cell migration in hindbrain (GO:0021535)4.95731239
14membrane assembly (GO:0071709)4.85063321
15positive regulation of dendritic spine morphogenesis (GO:0061003)4.83322963
16detection of temperature stimulus (GO:0016048)4.73244463
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.68585717
18neurotransmitter-gated ion channel clustering (GO:0072578)4.51188947
19response to pain (GO:0048265)4.43143422
20neurotransmitter catabolic process (GO:0042135)4.41362799
21neuronal action potential (GO:0019228)4.31897092
22behavioral response to ethanol (GO:0048149)4.22157840
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21741876
24cerebellar Purkinje cell differentiation (GO:0021702)4.08250987
25positive regulation of mitochondrial fission (GO:0090141)4.07724769
26norepinephrine metabolic process (GO:0042415)4.04912712
27establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.98039771
28mitochondrion transport along microtubule (GO:0047497)3.98039771
29negative regulation of dendrite morphogenesis (GO:0050774)3.97804113
30peripheral nervous system neuron development (GO:0048935)3.96516969
31central nervous system projection neuron axonogenesis (GO:0021952)3.95594468
32synaptic vesicle exocytosis (GO:0016079)3.94002446
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85030696
34neuromuscular synaptic transmission (GO:0007274)3.83638805
35neuronal ion channel clustering (GO:0045161)3.83384876
36ganglion development (GO:0061548)3.82412182
37catecholamine transport (GO:0051937)3.76924565
38positive regulation of synapse assembly (GO:0051965)3.75797988
39axon extension involved in axon guidance (GO:0048846)3.73494261
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.73494261
41auditory behavior (GO:0031223)3.71186559
42proline transport (GO:0015824)3.69265956
43maternal behavior (GO:0042711)3.67455318
44synaptic transmission, cholinergic (GO:0007271)3.63189129
45cochlea development (GO:0090102)3.63188971
46negative regulation of microtubule polymerization (GO:0031115)3.62602388
47layer formation in cerebral cortex (GO:0021819)3.61590717
48heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.61402570
49cell-cell junction maintenance (GO:0045217)3.60355257
50response to water (GO:0009415)3.58951034
51dopamine metabolic process (GO:0042417)3.58347356
52RNA destabilization (GO:0050779)3.55161400
53transmission of nerve impulse (GO:0019226)3.52477819
54histone H3-K9 demethylation (GO:0033169)3.52236229
55catecholamine biosynthetic process (GO:0042423)3.49890745
56catechol-containing compound biosynthetic process (GO:0009713)3.49890745
57mechanosensory behavior (GO:0007638)3.43874781
58head development (GO:0060322)3.43384337
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42990826
60mannosylation (GO:0097502)3.41515095
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40592115
62positive regulation of gastrulation (GO:2000543)3.39759526
63spinal cord association neuron differentiation (GO:0021527)3.37240796
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35047748
65axon extension (GO:0048675)3.34647622
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33892258
67dendritic spine organization (GO:0097061)3.33000982
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31638191
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.30062719
70NADH dehydrogenase complex assembly (GO:0010257)3.30062719
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30062719
72central nervous system neuron axonogenesis (GO:0021955)3.28962174
73mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.28856151
74positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.28856151
75parental behavior (GO:0060746)3.28653673
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26317342
77histone H3-K36 demethylation (GO:0070544)3.25846703
78regulation of collateral sprouting (GO:0048670)3.25545751
79dendrite morphogenesis (GO:0048813)3.25214588
80glutamate secretion (GO:0014047)3.25188233
81negative regulation of axon guidance (GO:1902668)3.24808466
82neurofilament cytoskeleton organization (GO:0060052)3.21959212
83activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.21870828
84positive regulation of potassium ion transmembrane transport (GO:1901381)3.19196045
85cellular response to nicotine (GO:0071316)3.18990121
86synapse assembly (GO:0007416)3.18002810
87postsynaptic membrane organization (GO:0001941)3.17762625
88regulation of cell maturation (GO:1903429)3.16035938
89dendrite development (GO:0016358)3.14240114
90cell proliferation in forebrain (GO:0021846)3.13966318
91neuron cell-cell adhesion (GO:0007158)3.11202501
92enteric nervous system development (GO:0048484)3.10417530
93negative regulation of axon extension involved in axon guidance (GO:0048843)3.08668428
94protein polyglutamylation (GO:0018095)3.07303316
95cranial nerve morphogenesis (GO:0021602)3.05190547
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04917537
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04692580
98positive regulation of synapse maturation (GO:0090129)3.02264243
99regulation of synapse structural plasticity (GO:0051823)3.01558385
100calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.01276934
101negative regulation of axonogenesis (GO:0050771)3.00940622
102ionotropic glutamate receptor signaling pathway (GO:0035235)3.00855068
103forebrain neuron differentiation (GO:0021879)2.99480246
104negative regulation of transcription regulatory region DNA binding (GO:2000678)2.99462557
105adult walking behavior (GO:0007628)2.98377224
106negative regulation of dendrite development (GO:2000171)2.98111688
107synaptic vesicle maturation (GO:0016188)2.97547283
108regulation of feeding behavior (GO:0060259)2.97031695
109neurotransmitter secretion (GO:0007269)2.96463744
110adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94833654
111dopamine receptor signaling pathway (GO:0007212)2.94008789
112regulation of dendrite morphogenesis (GO:0048814)2.93819102
113retinal ganglion cell axon guidance (GO:0031290)2.93027797
114cell differentiation in hindbrain (GO:0021533)2.92146413
115retinal cone cell development (GO:0046549)2.91929491
116membrane depolarization during action potential (GO:0086010)2.91887158
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91700979
118multicellular organismal response to stress (GO:0033555)2.90886599
119spinal cord development (GO:0021510)2.89199911
120action potential (GO:0001508)2.88767386
121protein insertion into membrane (GO:0051205)2.88688029
122regulation of vesicle fusion (GO:0031338)2.88545091
123negative regulation of amino acid transport (GO:0051956)2.87957425
124neuron projection extension (GO:1990138)2.87870766
125hippocampus development (GO:0021766)2.86272478
126establishment of mitochondrion localization (GO:0051654)2.86070393
127regulation of extent of cell growth (GO:0061387)2.84261566
128protein localization to synapse (GO:0035418)2.83562451
129cardiac ventricle formation (GO:0003211)2.83504997
130synaptic transmission, glutamatergic (GO:0035249)2.81333046
131clathrin coat assembly (GO:0048268)2.80710013
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.80189854
133substrate-independent telencephalic tangential migration (GO:0021826)2.80189854
134positive regulation of dendritic spine development (GO:0060999)2.79496228
135alanine transport (GO:0032328)2.78606100
136positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.77632574
137establishment of nucleus localization (GO:0040023)2.76445977
138neuron migration (GO:0001764)2.76103534
139protein complex biogenesis (GO:0070271)2.75949228
140regulation of dendritic spine morphogenesis (GO:0061001)2.75289373
141positive regulation of amino acid transport (GO:0051957)2.72400703
142cell junction maintenance (GO:0034331)2.71640665
143cardiac chamber formation (GO:0003207)2.71012583
144glycine transport (GO:0015816)2.70525873
145dopamine biosynthetic process (GO:0042416)2.69667640
146epithelial cilium movement (GO:0003351)2.68484481
147fear response (GO:0042596)2.68480513
148regulation of synapse assembly (GO:0051963)2.66171238
149cerebral cortex neuron differentiation (GO:0021895)2.65485506
150neurotransmitter transport (GO:0006836)2.65434739
151regulation of synaptic vesicle transport (GO:1902803)2.65428793
152regulation of neurotransmitter secretion (GO:0046928)2.65207272
153regulation of synaptic vesicle exocytosis (GO:2000300)2.65193170
154behavioral response to pain (GO:0048266)2.64274691
155regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63805517
156sequestering of actin monomers (GO:0042989)2.63551302
157calcium-mediated signaling using intracellular calcium source (GO:0035584)2.63378628
158regulation of postsynaptic membrane potential (GO:0060078)2.63259279
159nonmotile primary cilium assembly (GO:0035058)2.63120126
160regulation of neuronal synaptic plasticity (GO:0048168)2.63087740
161interferon-gamma production (GO:0032609)2.62942614
162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.62038045
163cranial nerve development (GO:0021545)2.61899418
164regulation of axon guidance (GO:1902667)2.60745831
165protein localization to cilium (GO:0061512)2.60582646
166cellular response to nerve growth factor stimulus (GO:1990090)2.60212994
167response to nerve growth factor (GO:1990089)2.60212994
168positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.58881820
169neuronal action potential propagation (GO:0019227)2.58529348
170neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58312240
171neuron recognition (GO:0008038)2.58050061
172regulation of microtubule polymerization (GO:0031113)2.57534794
173presynaptic membrane organization (GO:0097090)10.5879150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.72237581
2EZH2_22144423_ChIP-Seq_EOC_Human4.67614290
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.21023636
4GBX2_23144817_ChIP-Seq_PC3_Human4.19124480
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04582737
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01382118
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96813109
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75188123
9IGF1R_20145208_ChIP-Seq_DFB_Human2.74096006
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.59947881
11TAF15_26573619_Chip-Seq_HEK293_Human2.58957814
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56377563
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55243602
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55109454
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52466155
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52466155
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45838481
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43744306
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36452798
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36356099
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33676767
22REST_21632747_ChIP-Seq_MESCs_Mouse2.33167856
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.31813997
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20775280
25NR3C1_23031785_ChIP-Seq_PC12_Mouse2.19834422
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.14324942
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.09871730
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91225683
29SMAD4_21799915_ChIP-Seq_A2780_Human1.90665811
30ZNF274_21170338_ChIP-Seq_K562_Hela1.89930328
31IRF1_19129219_ChIP-ChIP_H3396_Human1.85822286
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.85367239
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.84031208
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83686818
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.73882607
36CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.67799728
37* P300_19829295_ChIP-Seq_ESCs_Human1.65033783
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64636686
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64470039
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59865424
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59729841
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59521109
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56356148
44VDR_22108803_ChIP-Seq_LS180_Human1.54975918
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53899039
46DROSHA_22980978_ChIP-Seq_HELA_Human1.49853797
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47274466
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.47191281
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46178853
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44007507
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42492100
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41063415
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36482902
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35694433
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31408007
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.31349842
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31120413
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29473045
59RNF2_27304074_Chip-Seq_NSC_Mouse1.27248155
60AR_25329375_ChIP-Seq_VCAP_Human1.26407004
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26363495
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23733388
63FUS_26573619_Chip-Seq_HEK293_Human1.23051122
64BCAT_22108803_ChIP-Seq_LS180_Human1.20875099
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20466462
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.19217334
67AR_21572438_ChIP-Seq_LNCaP_Human1.18706361
68HTT_18923047_ChIP-ChIP_STHdh_Human1.18157454
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17559177
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.17374423
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15688501
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14557128
73* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14284516
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13408448
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.12833955
76CTCF_27219007_Chip-Seq_Bcells_Human1.11012966
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10590917
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10571455
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09473335
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09007925
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07088826
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06903777
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06185718
84KDM2B_26808549_Chip-Seq_REH_Human1.04597941
85JUN_21703547_ChIP-Seq_K562_Human1.04022753
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.03791091
87* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03468032
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.03124360
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02813490
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.02415849
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02392700
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02290092
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00051091
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99697233
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99577968
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99340898
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99340898
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.99195092
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.99034318
100RUNX2_22187159_ChIP-Seq_PCA_Human0.98087378
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.98086349
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.97512118
103EWS_26573619_Chip-Seq_HEK293_Human0.96132158
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95372936
105* TAL1_26923725_Chip-Seq_HPCs_Mouse0.95041930
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.93991729
107* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93734437
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.93577746
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91750603
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91692489
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90792711
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90185067
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89820158
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88464434
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.87554192
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87310738
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.87252703
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86773213
119* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85894601
120NCOR_22424771_ChIP-Seq_293T_Human0.85795065
121* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85638903
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85495027
123TCF4_23295773_ChIP-Seq_U87_Human0.85488235
124* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85152044
125STAT3_23295773_ChIP-Seq_U87_Human0.84918985
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84324489
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84159919
128AR_19668381_ChIP-Seq_PC3_Human0.82915910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.93774042
2MP0002735_abnormal_chemical_nociception4.77958742
3MP0001968_abnormal_touch/_nociception4.34019522
4MP0002736_abnormal_nociception_after4.10456007
5MP0006276_abnormal_autonomic_nervous3.72039634
6MP0004270_analgesia3.52871638
7MP0003787_abnormal_imprinting3.50099101
8MP0005171_absent_coat_pigmentation3.15182836
9MP0002733_abnormal_thermal_nociception3.09965631
10MP0002734_abnormal_mechanical_nocicepti3.01950811
11MP0010386_abnormal_urinary_bladder2.98623776
12MP0001970_abnormal_pain_threshold2.93777207
13MP0009379_abnormal_foot_pigmentation2.83640280
14MP0004858_abnormal_nervous_system2.80807861
15MP0004859_abnormal_synaptic_plasticity2.70798690
16MP0003121_genomic_imprinting2.68814410
17MP0001905_abnormal_dopamine_level2.60382445
18MP0009745_abnormal_behavioral_response2.57069765
19MP0002638_abnormal_pupillary_reflex2.44463453
20MP0002751_abnormal_autonomic_nervous2.42356139
21MP0000372_irregular_coat_pigmentation2.37665120
22MP0002272_abnormal_nervous_system2.36794920
23MP0003123_paternal_imprinting2.32164848
24MP0003635_abnormal_synaptic_transmissio2.30193088
25MP0001440_abnormal_grooming_behavior2.12986501
26MP0003890_abnormal_embryonic-extraembry2.06827079
27MP0002653_abnormal_ependyma_morphology2.04919453
28MP0004145_abnormal_muscle_electrophysio2.03306983
29MP0002064_seizures2.00922034
30MP0001986_abnormal_taste_sensitivity2.00478393
31MP0001188_hyperpigmentation1.95372226
32MP0002063_abnormal_learning/memory/cond1.93408661
33MP0004742_abnormal_vestibular_system1.89803896
34MP0008877_abnormal_DNA_methylation1.88322031
35MP0006292_abnormal_olfactory_placode1.86593836
36MP0003567_abnormal_fetal_cardiomyocyte1.82838669
37MP0002572_abnormal_emotion/affect_behav1.81395539
38MP0002067_abnormal_sensory_capabilities1.71362499
39MP0008995_early_reproductive_senescence1.70794040
40MP0008569_lethality_at_weaning1.70609523
41MP0008872_abnormal_physiological_respon1.67533662
42MP0005409_darkened_coat_color1.65564373
43MP0002102_abnormal_ear_morphology1.59495818
44MP0002184_abnormal_innervation1.55809134
45MP0002909_abnormal_adrenal_gland1.55129254
46MP0005386_behavior/neurological_phenoty1.43780204
47MP0004924_abnormal_behavior1.43780204
48MP0005499_abnormal_olfactory_system1.39427305
49MP0005394_taste/olfaction_phenotype1.39427305
50MP0000462_abnormal_digestive_system1.37989634
51MP0000538_abnormal_urinary_bladder1.36862991
52MP0005248_abnormal_Harderian_gland1.36849213
53MP0008789_abnormal_olfactory_epithelium1.36821402
54MP0003633_abnormal_nervous_system1.36015882
55MP0000778_abnormal_nervous_system1.33802264
56MP0001529_abnormal_vocalization1.32921195
57MP0009046_muscle_twitch1.31227266
58MP0004811_abnormal_neuron_physiology1.30400135
59MP0003303_peritoneal_inflammation1.28948935
60MP0003329_amyloid_beta_deposits1.26831606
61MP0001984_abnormal_olfaction1.25583738
62MP0002557_abnormal_social/conspecific_i1.25081049
63MP0003011_delayed_dark_adaptation1.25012421
64MP0000955_abnormal_spinal_cord1.24858645
65MP0005408_hypopigmentation1.23929695
66MP0001486_abnormal_startle_reflex1.23314203
67MP0003122_maternal_imprinting1.21730248
68MP0005646_abnormal_pituitary_gland1.15886845
69MP0001501_abnormal_sleep_pattern1.15854121
70MP0003861_abnormal_nervous_system1.14480376
71MP0001727_abnormal_embryo_implantation1.12911357
72MP0001502_abnormal_circadian_rhythm1.10318371
73MP0002882_abnormal_neuron_morphology1.09614498
74MP0004142_abnormal_muscle_tone1.09430372
75MP0001485_abnormal_pinna_reflex1.08627624
76MP0003880_abnormal_central_pattern1.08030497
77MP0006072_abnormal_retinal_apoptosis1.03653180
78MP0003631_nervous_system_phenotype1.03452712
79MP0005391_vision/eye_phenotype1.01520619
80MP0000747_muscle_weakness0.98872668
81MP0002163_abnormal_gland_morphology0.98809329
82MP0005187_abnormal_penis_morphology0.98452666
83MP0000534_abnormal_ureter_morphology0.97859738
84MP0004133_heterotaxia0.97750978
85MP0004885_abnormal_endolymph0.94583063
86MP0004130_abnormal_muscle_cell0.93495176
87MP0002066_abnormal_motor_capabilities/c0.91250889
88MP0002752_abnormal_somatic_nervous0.90590434
89MP0003656_abnormal_erythrocyte_physiolo0.89951773
90MP0005645_abnormal_hypothalamus_physiol0.89615168
91MP0003868_abnormal_feces_composition0.89560030
92MP0001919_abnormal_reproductive_system0.89426375
93MP0001348_abnormal_lacrimal_gland0.88252035
94MP0005535_abnormal_body_temperature0.88136960
95MP0001293_anophthalmia0.84649919
96MP0001299_abnormal_eye_distance/0.81760847
97MP0003119_abnormal_digestive_system0.81491652
98MP0002160_abnormal_reproductive_system0.80226310
99MP0001340_abnormal_eyelid_morphology0.80126402
100MP0005551_abnormal_eye_electrophysiolog0.80047481
101MP0005197_abnormal_uvea_morphology0.79918990
102MP0008874_decreased_physiological_sensi0.79135778
103MP0000647_abnormal_sebaceous_gland0.78960558
104MP0002229_neurodegeneration0.78563598
105MP0000920_abnormal_myelination0.78271603
106MP0004147_increased_porphyrin_level0.77732207
107MP0003879_abnormal_hair_cell0.76864759
108MP0005389_reproductive_system_phenotype0.76035081
109MP0003938_abnormal_ear_development0.75789527
110MP0003942_abnormal_urinary_system0.75097674
111MP0002152_abnormal_brain_morphology0.74599181
112MP0003634_abnormal_glial_cell0.72795400
113MP0005379_endocrine/exocrine_gland_phen0.72177835
114MP0002876_abnormal_thyroid_physiology0.71985491
115MP0000631_abnormal_neuroendocrine_gland0.71862022
116MP0001963_abnormal_hearing_physiology0.69861788
117MP0002234_abnormal_pharynx_morphology0.69722936
118MP0001286_abnormal_eye_development0.67111578
119MP0002177_abnormal_outer_ear0.67069609
120MP0003646_muscle_fatigue0.67003884
121MP0000026_abnormal_inner_ear0.63339060
122MP0005167_abnormal_blood-brain_barrier0.63127696
123MP0005253_abnormal_eye_physiology0.61728360
124MP0003385_abnormal_body_wall0.61295959
125MP0000751_myopathy0.60929231
126MP0002069_abnormal_eating/drinking_beha0.57210521
127MP0000049_abnormal_middle_ear0.56518630
128MP0000427_abnormal_hair_cycle0.54670781
129MP0005195_abnormal_posterior_eye0.52971304
130MP0005423_abnormal_somatic_nervous0.51737583
131MP0000681_abnormal_thyroid_gland0.50873996
132MP0000604_amyloidosis0.50821347
133MP0004134_abnormal_chest_morphology0.49601201

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.12852972
2Retinal dysplasia (HP:0007973)5.55129790
3Myokymia (HP:0002411)5.14198314
4Abnormal autonomic nervous system physiology (HP:0012332)5.13736356
5Retinal atrophy (HP:0001105)5.10330809
6Focal motor seizures (HP:0011153)4.77707225
7Intestinal atresia (HP:0011100)4.75764105
8Orthostatic hypotension (HP:0001278)4.45969143
9Buphthalmos (HP:0000557)4.10437720
10Anterior segment dysgenesis (HP:0007700)4.03921085
11Dysautonomia (HP:0002459)3.97075107
12Type II lissencephaly (HP:0007260)3.96206379
13Cerebellar dysplasia (HP:0007033)3.91714624
14Focal seizures (HP:0007359)3.83072688
15Thyroid carcinoma (HP:0002890)3.67817880
16Hypoventilation (HP:0002791)3.66958265
17Abnormal pancreas size (HP:0012094)3.65571524
18Annular pancreas (HP:0001734)3.61246688
19Failure to thrive in infancy (HP:0001531)3.33923590
20Abnormality of pain sensation (HP:0010832)3.32039983
21Impaired pain sensation (HP:0007328)3.32039983
22Medial flaring of the eyebrow (HP:0010747)3.31080793
23Impaired vibration sensation in the lower limbs (HP:0002166)3.29733021
24Spinal rigidity (HP:0003306)3.29363514
25Esophageal atresia (HP:0002032)3.26281892
26Polyphagia (HP:0002591)3.22632733
27Abnormality of the lower motor neuron (HP:0002366)3.21673202
28Aplasia/Hypoplasia of the spleen (HP:0010451)3.21659360
29Difficulty climbing stairs (HP:0003551)3.20608923
30Gait imbalance (HP:0002141)3.16990390
31Supernumerary spleens (HP:0009799)3.15335320
32Pheochromocytoma (HP:0002666)3.15080174
33Febrile seizures (HP:0002373)3.14621883
34Ulnar claw (HP:0001178)3.12473088
35Papillary thyroid carcinoma (HP:0002895)3.10137371
36Neoplasm of the adrenal cortex (HP:0100641)3.01858500
37Abnormality of the aortic arch (HP:0012303)3.00985644
38Neonatal hypoglycemia (HP:0001998)2.96114639
39Ankle clonus (HP:0011448)2.95215159
40Bradycardia (HP:0001662)2.93187269
41Visual hallucinations (HP:0002367)2.92781922
42Myotonia (HP:0002486)2.92013588
43Inability to walk (HP:0002540)2.91066655
44Autoamputation (HP:0001218)2.90473986
45Acute necrotizing encephalopathy (HP:0006965)2.87886274
46Congenital primary aphakia (HP:0007707)2.86083175
47Hepatoblastoma (HP:0002884)2.84595679
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82996192
49Bony spicule pigmentary retinopathy (HP:0007737)2.82231537
50Absent speech (HP:0001344)2.81001201
51Abnormality of magnesium homeostasis (HP:0004921)2.80748858
52Stomach cancer (HP:0012126)2.78513384
53Tented upper lip vermilion (HP:0010804)2.76539652
54Neuroendocrine neoplasm (HP:0100634)2.74437330
55Renal dysplasia (HP:0000110)2.73355434
56Limb dystonia (HP:0002451)2.72819592
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.71370585
58Action tremor (HP:0002345)2.70653888
59Nemaline bodies (HP:0003798)2.70258720
60Nephrogenic diabetes insipidus (HP:0009806)2.69770020
61Atonic seizures (HP:0010819)2.69106586
62Hypoplasia of the brainstem (HP:0002365)2.66307746
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.66307746
64Oligomenorrhea (HP:0000876)2.63616653
65Drooling (HP:0002307)2.62794288
66Vaginal atresia (HP:0000148)2.61585181
67Urinary bladder sphincter dysfunction (HP:0002839)2.55782390
68Progressive macrocephaly (HP:0004481)2.55516374
69Specific learning disability (HP:0001328)2.55291286
70Genital tract atresia (HP:0001827)2.51007430
71Oligodactyly (hands) (HP:0001180)2.50522362
72Insidious onset (HP:0003587)2.49075824
73Termporal pattern (HP:0011008)2.49075824
74Severe muscular hypotonia (HP:0006829)2.48538884
75Congenital glaucoma (HP:0001087)2.47488466
76Abnormal rod and cone electroretinograms (HP:0008323)2.46548641
77Neoplasm of the adrenal gland (HP:0100631)2.46514507
78Anosmia (HP:0000458)2.45727633
79Molar tooth sign on MRI (HP:0002419)2.44683926
80Abnormality of midbrain morphology (HP:0002418)2.44683926
81Fetal akinesia sequence (HP:0001989)2.43824183
82Asplenia (HP:0001746)2.43232954
83Sensory axonal neuropathy (HP:0003390)2.42681811
84Abnormal mitochondria in muscle tissue (HP:0008316)2.42076071
85Chronic hepatic failure (HP:0100626)2.39838024
86Excessive salivation (HP:0003781)2.38537999
87Nephronophthisis (HP:0000090)2.37580146
88Pendular nystagmus (HP:0012043)2.36929955
89Amyotrophic lateral sclerosis (HP:0007354)2.36905293
90Optic nerve hypoplasia (HP:0000609)2.36487132
91Pancreatic fibrosis (HP:0100732)2.36380502
92Cortical dysplasia (HP:0002539)2.33602649
93Amblyopia (HP:0000646)2.32411513
94Occipital encephalocele (HP:0002085)2.31442562
95Sclerocornea (HP:0000647)2.28196991
96Rib fusion (HP:0000902)2.27151077
97Morphological abnormality of the pyramidal tract (HP:0002062)2.26977605
98Progressive cerebellar ataxia (HP:0002073)2.26822898
99Abolished electroretinogram (ERG) (HP:0000550)2.26361851
100Intellectual disability, moderate (HP:0002342)2.26165503
101Diastasis recti (HP:0001540)2.22657343
102Poor coordination (HP:0002370)2.22060163
103Abnormality of the corticospinal tract (HP:0002492)2.21554665
104Broad-based gait (HP:0002136)2.20536290
105True hermaphroditism (HP:0010459)2.17125004
106Urinary urgency (HP:0000012)2.16800628
107Volvulus (HP:0002580)2.16538738
108Acute encephalopathy (HP:0006846)2.15607460
109Scanning speech (HP:0002168)2.15502340
110Anxiety (HP:0000739)2.13692016
111Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12950226
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12950226
113Gastrointestinal atresia (HP:0002589)2.10445037
114Anophthalmia (HP:0000528)2.10134747
115Neuroblastoma (HP:0003006)2.10061143
116Primitive neuroectodermal tumor (HP:0030065)2.10061143
117Neuroblastic tumors (HP:0004376)2.10061143
118Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.10061143
119Limb-girdle muscle weakness (HP:0003325)2.08542601
120Dialeptic seizures (HP:0011146)2.08326055
121Epidermoid cyst (HP:0200040)2.08125235
122Spastic gait (HP:0002064)2.06975300
123Genetic anticipation (HP:0003743)2.06497449
124Colon cancer (HP:0003003)2.04290892
125Non-midline cleft lip (HP:0100335)2.03940606
126Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02899641
127Pachygyria (HP:0001302)2.01583524
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01431132
129Anencephaly (HP:0002323)2.00723803
130Slender build (HP:0001533)2.00509947
131Spastic tetraplegia (HP:0002510)2.00005982
132Lissencephaly (HP:0001339)1.99984317
133Anomalous pulmonary venous return (HP:0010772)1.99269653
134Hyperthyroidism (HP:0000836)1.98526285
135Abnormality of the anterior chamber (HP:0000593)1.98395971
136Polymicrogyria (HP:0002126)1.97555374
137Narrow nasal bridge (HP:0000446)1.97437204
138Type 1 muscle fiber predominance (HP:0003803)1.97243615
139Growth hormone deficiency (HP:0000824)1.96395374
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.96077230
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96077230
142Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94882196
143Ragged-red muscle fibers (HP:0003200)1.94063172
144Double outlet right ventricle (HP:0001719)1.93637394
145Congenital malformation of the right heart (HP:0011723)1.93637394
146Optic disc pallor (HP:0000543)1.92778133
147Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.92017938
148Hyperparathyroidism (HP:0000843)1.91856214
149Abnormality of the parathyroid morphology (HP:0011766)1.91389394
150Wrist flexion contracture (HP:0001239)1.89808218
151Abnormal hair whorl (HP:0010721)1.89672368
152Agitation (HP:0000713)1.89498951
153Pancreatic cysts (HP:0001737)1.89232372
154Abnormal eating behavior (HP:0100738)1.88983106
155Exotropia (HP:0000577)1.88336498
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87205193
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86759118
158Severe visual impairment (HP:0001141)1.86710069
159Aplasia/Hypoplasia of the macula (HP:0008059)1.86462696
160Epileptic encephalopathy (HP:0200134)1.86432809
161Abnormality of the renal medulla (HP:0100957)1.85767401
162Neoplasm of the thyroid gland (HP:0100031)1.85344467
163Abnormality of the labia minora (HP:0012880)1.80861429
164Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76049007
165Oligodactyly (HP:0012165)1.75685152
166Status epilepticus (HP:0002133)1.74631342
167Aplasia/Hypoplasia of the lens (HP:0008063)1.74565127
168Abnormality of the vocal cords (HP:0008777)1.72673528
169Thyroid-stimulating hormone excess (HP:0002925)1.71380032
170Micropenis (HP:0000054)1.70353518
171Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.70037604
172Restlessness (HP:0000711)1.69540381
173Postaxial hand polydactyly (HP:0001162)1.69368200
174Retinitis pigmentosa (HP:0000510)1.69254407
175Attenuation of retinal blood vessels (HP:0007843)1.68003053
176Depressed nasal tip (HP:0000437)1.67786869
177Labial hypoplasia (HP:0000066)1.66492875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.66683530
2ADRBK23.69040451
3CASK3.31874489
4DYRK33.00946364
5CSNK1G32.96505133
6PNCK2.81144287
7LMTK22.78482038
8GRK52.78068688
9TRIM282.61967659
10CSNK1A1L2.56629469
11MATK2.42785803
12GRK72.30181521
13CSNK1G22.30017440
14EPHB22.20753051
15MARK12.13903728
16MINK12.12607477
17DYRK1B2.10748457
18CSNK1G12.04325231
19WNK31.99949666
20PRPF4B1.88848980
21SGK2231.87273731
22SGK4941.87273731
23FES1.81037726
24ADRBK11.80658811
25UHMK11.78649429
26EPHA41.76498704
27KSR21.76325712
28MAP2K11.76138937
29NTRK31.70433383
30SGK21.66540247
31PHKG21.65958600
32PHKG11.65958600
33EPHA31.62340787
34LIMK11.58542838
35MAP2K71.54952123
36ARAF1.52896382
37MAP3K21.36778667
38STK161.36752659
39DYRK1A1.34546520
40PLK21.28035469
41FER1.21467604
42RIPK41.21436106
43MAP3K41.17918726
44NTRK21.14066374
45MAPK131.12688395
46CAMKK11.11927004
47MAP3K111.09395437
48FGR1.09350970
49EPHB11.05660992
50MAP3K121.05498588
51PRKCE1.02168426
52TYRO31.00664823
53PLK41.00583771
54CDK190.97794615
55CAMK2G0.97441933
56PAK60.96105533
57MAP4K20.94901229
58DAPK20.94429575
59MARK30.93746038
60WNK10.92068837
61KSR10.91714580
62SGK30.90490162
63SIK30.88347975
64MAP3K10.85032655
65CAMK40.84183521
66AKT30.83769579
67ERBB20.83466135
68ERBB30.82418112
69CDK50.81335509
70DYRK20.79614298
71CAMK1G0.79552338
72PIK3CA0.79402000
73MAPKAPK50.79165487
74TNIK0.77947856
75CAMKK20.76524720
76SIK20.76403730
77PRKCG0.75934935
78TSSK60.74989820
79MAP3K60.74536844
80PINK10.71060715
81YES10.70441101
82MAP3K90.69996139
83ICK0.69301831
84BCR0.65753397
85CAMK2A0.63188436
86PRKCZ0.62826932
87MAPK40.61762112
88INSRR0.60045674
89BCKDK0.59774528
90PRKACA0.58458343
91CSNK1A10.56523320
92RPS6KA20.56431366
93TLK10.56167202
94PLK30.55134530
95MAPK150.54540156
96CSNK1E0.54341011
97PRKAA10.53975485
98TESK10.53546009
99MARK20.52929096
100OXSR10.52447876
101ZAK0.52200689
102RPS6KB10.51484346
103SRPK10.50959953
104STK110.50220898
105PKN10.49986417
106PRKG10.49824443
107CDK140.49449245
108RET0.49399234
109PKN20.48496805
110CAMK2D0.48246244
111STK390.48200208
112TNK20.47653078
113STK380.47196457
114CAMK2B0.46186455
115NEK20.45358231
116PRKCH0.43773871
117MAP2K40.43551526
118IRAK20.43070419
119PAK30.41933771
120NME10.41373386
121PRKACG0.39320954
122FRK0.37139963
123GRK10.36970445
124CSNK1D0.36932533
125CDK180.35855622
126MUSK0.35170581
127ROCK20.34947018
128RPS6KA50.34199997
129DMPK0.33944793
130FYN0.32161502
131MAPK80.32080705
132RAF10.30539038
133MET0.30455128
134FLT30.30264626
135FGFR30.29986996
136WNK40.29902806
137HIPK20.29901655
138CAMK10.29540999
139CDK150.29108955
140CDK11A0.26270101
141AURKA0.26147613
142ROCK10.24922511

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.60750978
2Sulfur metabolism_Homo sapiens_hsa009203.55850813
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.03845762
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.38558870
5Oxidative phosphorylation_Homo sapiens_hsa001902.17280560
6Cholinergic synapse_Homo sapiens_hsa047252.15083522
7Dopaminergic synapse_Homo sapiens_hsa047282.09516621
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07718669
9Olfactory transduction_Homo sapiens_hsa047402.00226514
10Tyrosine metabolism_Homo sapiens_hsa003501.97904859
11Circadian entrainment_Homo sapiens_hsa047131.96500338
12Nicotine addiction_Homo sapiens_hsa050331.95552696
13Serotonergic synapse_Homo sapiens_hsa047261.95538392
14Cocaine addiction_Homo sapiens_hsa050301.93047871
15Insulin secretion_Homo sapiens_hsa049111.92385498
16Amphetamine addiction_Homo sapiens_hsa050311.86228580
17Long-term depression_Homo sapiens_hsa047301.85473536
18Parkinsons disease_Homo sapiens_hsa050121.84825949
19Glutamatergic synapse_Homo sapiens_hsa047241.80815806
20Salivary secretion_Homo sapiens_hsa049701.79891733
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72079089
22Alzheimers disease_Homo sapiens_hsa050101.70966319
23Collecting duct acid secretion_Homo sapiens_hsa049661.70781365
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69021654
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68293188
26Phenylalanine metabolism_Homo sapiens_hsa003601.68211125
27Renin secretion_Homo sapiens_hsa049241.65755561
28Huntingtons disease_Homo sapiens_hsa050161.65127886
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62479997
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.57788404
31Taste transduction_Homo sapiens_hsa047421.47850111
32Long-term potentiation_Homo sapiens_hsa047201.44723720
33GABAergic synapse_Homo sapiens_hsa047271.31535095
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29905841
35Gap junction_Homo sapiens_hsa045401.29279416
36Phototransduction_Homo sapiens_hsa047441.25198949
37Morphine addiction_Homo sapiens_hsa050321.24352397
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16762753
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15935431
40African trypanosomiasis_Homo sapiens_hsa051431.09721414
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08667064
42Calcium signaling pathway_Homo sapiens_hsa040201.07885443
43Axon guidance_Homo sapiens_hsa043601.07547552
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03622267
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.00414098
46Gastric acid secretion_Homo sapiens_hsa049710.97998553
47Cardiac muscle contraction_Homo sapiens_hsa042600.97087528
48Endometrial cancer_Homo sapiens_hsa052130.96132919
49Vibrio cholerae infection_Homo sapiens_hsa051100.94828782
50Pancreatic secretion_Homo sapiens_hsa049720.94328613
51Estrogen signaling pathway_Homo sapiens_hsa049150.92453841
52Wnt signaling pathway_Homo sapiens_hsa043100.92217640
53Thyroid hormone synthesis_Homo sapiens_hsa049180.91989226
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90744660
55GnRH signaling pathway_Homo sapiens_hsa049120.90135415
56Melanogenesis_Homo sapiens_hsa049160.89872250
57Butanoate metabolism_Homo sapiens_hsa006500.89707848
58Histidine metabolism_Homo sapiens_hsa003400.87540848
59Thyroid cancer_Homo sapiens_hsa052160.87023032
60Notch signaling pathway_Homo sapiens_hsa043300.86808521
61Alcoholism_Homo sapiens_hsa050340.85109275
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84865001
63Type II diabetes mellitus_Homo sapiens_hsa049300.81945387
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78947510
65Oxytocin signaling pathway_Homo sapiens_hsa049210.77309308
66Fatty acid metabolism_Homo sapiens_hsa012120.73810195
67Fatty acid elongation_Homo sapiens_hsa000620.73565779
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73056450
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72734268
70Dorso-ventral axis formation_Homo sapiens_hsa043200.71735859
71Steroid biosynthesis_Homo sapiens_hsa001000.71358167
72Regulation of autophagy_Homo sapiens_hsa041400.70797002
73Peroxisome_Homo sapiens_hsa041460.70640172
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68285957
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66475861
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65958144
77cAMP signaling pathway_Homo sapiens_hsa040240.65818305
78Bile secretion_Homo sapiens_hsa049760.65028487
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63540802
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62833718
81Colorectal cancer_Homo sapiens_hsa052100.62418964
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60904545
83Hippo signaling pathway_Homo sapiens_hsa043900.60103930
84Protein export_Homo sapiens_hsa030600.59210169
85Selenocompound metabolism_Homo sapiens_hsa004500.56635851
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56412263
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.56050352
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55009210
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53877862
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53728683
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53688618
92Pyruvate metabolism_Homo sapiens_hsa006200.52895185
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.52847095
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52753684
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52628701
96Hedgehog signaling pathway_Homo sapiens_hsa043400.51794792
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.51790212
98ErbB signaling pathway_Homo sapiens_hsa040120.51709343
99Prion diseases_Homo sapiens_hsa050200.51275523
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50924614
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50209910
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49160803
103Ether lipid metabolism_Homo sapiens_hsa005650.49148943
104Dilated cardiomyopathy_Homo sapiens_hsa054140.48758917
105Ovarian steroidogenesis_Homo sapiens_hsa049130.48078816
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47977786
107Circadian rhythm_Homo sapiens_hsa047100.47298270
108Fatty acid biosynthesis_Homo sapiens_hsa000610.46767901
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43632820
110MAPK signaling pathway_Homo sapiens_hsa040100.43209048
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42145397
112Phagosome_Homo sapiens_hsa041450.42079028
113RNA degradation_Homo sapiens_hsa030180.41878196
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40956545
115Glioma_Homo sapiens_hsa052140.38309701
116Inositol phosphate metabolism_Homo sapiens_hsa005620.36075178
117Lysine degradation_Homo sapiens_hsa003100.35277433
118Renin-angiotensin system_Homo sapiens_hsa046140.34884608
119Basal transcription factors_Homo sapiens_hsa030220.34745512
120Oocyte meiosis_Homo sapiens_hsa041140.34580154
121Glucagon signaling pathway_Homo sapiens_hsa049220.34178228
122Rap1 signaling pathway_Homo sapiens_hsa040150.33736260
123Tryptophan metabolism_Homo sapiens_hsa003800.33145017
124Propanoate metabolism_Homo sapiens_hsa006400.32161377
125Choline metabolism in cancer_Homo sapiens_hsa052310.31773915
126Fat digestion and absorption_Homo sapiens_hsa049750.31652404
127Endocytosis_Homo sapiens_hsa041440.31204048
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31026997
129Linoleic acid metabolism_Homo sapiens_hsa005910.30971814
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.30201487
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30182423
132Metabolic pathways_Homo sapiens_hsa011000.29636859
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.29180074
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29111852
135Ras signaling pathway_Homo sapiens_hsa040140.28691467
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28482809
137Arginine and proline metabolism_Homo sapiens_hsa003300.28442670

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