INSL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.98993829
2labyrinthine layer development (GO:0060711)9.87795846
3plasma membrane fusion (GO:0045026)9.84746153
4multicellular organism reproduction (GO:0032504)9.27990633
5spermatid development (GO:0007286)8.93137390
6melanin biosynthetic process (GO:0042438)8.36579402
7axonemal dynein complex assembly (GO:0070286)8.32179173
8epithelial cilium movement (GO:0003351)8.21454734
9anatomical structure regression (GO:0060033)8.18316892
10motile cilium assembly (GO:0044458)7.91078700
11reproduction (GO:0000003)7.90212843
12oxygen transport (GO:0015671)7.89427413
13melanin metabolic process (GO:0006582)7.66359331
14secondary metabolite biosynthetic process (GO:0044550)7.40564396
15cilium or flagellum-dependent cell motility (GO:0001539)6.99784319
16regulation of cilium movement (GO:0003352)6.79666937
17synaptonemal complex assembly (GO:0007130)6.77355918
18synaptonemal complex organization (GO:0070193)6.68969919
19single fertilization (GO:0007338)6.64064033
20glutathione derivative metabolic process (GO:1901685)6.50127327
21glutathione derivative biosynthetic process (GO:1901687)6.50127327
22sequestering of actin monomers (GO:0042989)6.45414563
23cilium movement (GO:0003341)6.44668069
24seminiferous tubule development (GO:0072520)6.43489347
25negative regulation of kidney development (GO:0090185)6.41232667
26sperm capacitation (GO:0048240)6.37010710
27piRNA metabolic process (GO:0034587)6.29345752
28male meiosis (GO:0007140)6.24758328
29organic cation transport (GO:0015695)6.13284839
30* spermatogenesis (GO:0007283)6.09790832
31* male gamete generation (GO:0048232)6.07502240
32SMAD protein signal transduction (GO:0060395)6.04901654
33gas transport (GO:0015669)6.03975273
34mesenchymal to epithelial transition (GO:0060231)5.97557619
35fertilization (GO:0009566)5.83662817
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.81072111
37sex determination (GO:0007530)5.74250006
38cornea development in camera-type eye (GO:0061303)5.73581347
39urogenital system development (GO:0001655)5.61159303
40* gamete generation (GO:0007276)5.55494729
41androgen biosynthetic process (GO:0006702)5.52327158
42negative regulation of macrophage differentiation (GO:0045650)5.46945507
43regulation of gonadotropin secretion (GO:0032276)5.16339587
44* cellular process involved in reproduction in multicellular organism (GO:0022412)5.16130739
45nephron tubule formation (GO:0072079)5.12079302
46germ cell development (GO:0007281)5.07012140
47cerebellar Purkinje cell layer development (GO:0021680)5.02988759
48DNA packaging (GO:0006323)4.99130015
49chromosome condensation (GO:0030261)4.94427678
50negative regulation of inclusion body assembly (GO:0090084)4.89548731
51microtubule depolymerization (GO:0007019)4.74320601
52response to interleukin-6 (GO:0070741)4.73657207
53positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)4.71604413
54calcium ion-dependent exocytosis (GO:0017156)4.60499764
55chromosome organization involved in meiosis (GO:0070192)4.57779933
56male meiosis I (GO:0007141)4.54456593
57regulation of metanephros development (GO:0072215)4.50992525
58male sex determination (GO:0030238)4.44129844
59cell recognition (GO:0008037)4.41570734
60regulation of inclusion body assembly (GO:0090083)4.40721409
61melanocyte differentiation (GO:0030318)4.38364292
62* multicellular organismal reproductive process (GO:0048609)4.36792757
63ventricular system development (GO:0021591)4.34572270
64regulation of meiosis I (GO:0060631)4.19170661
65Leydig cell differentiation (GO:0033327)4.18981503
66positive regulation of odontogenesis (GO:0042482)4.18494788
67DNA methylation involved in gamete generation (GO:0043046)4.16650404
68cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.15220831
69microtubule severing (GO:0051013)4.10760483
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08480423
71gonadal mesoderm development (GO:0007506)3.98327615
72phenol-containing compound biosynthetic process (GO:0046189)3.96992115
73pigment cell differentiation (GO:0050931)3.95286695
74meiotic nuclear division (GO:0007126)3.94261355
75genitalia morphogenesis (GO:0035112)3.92346473
76positive regulation of macrophage activation (GO:0043032)3.91953775
77glycerol ether metabolic process (GO:0006662)3.85365269
78behavioral response to nicotine (GO:0035095)3.82307998
79regulation of microtubule-based movement (GO:0060632)3.81004100
80interferon-gamma secretion (GO:0072643)3.77024624
81left/right pattern formation (GO:0060972)3.76431616
82multicellular organismal development (GO:0007275)3.67970283
83regulation of protein kinase C signaling (GO:0090036)3.64873044
84meiosis I (GO:0007127)3.61069640
85positive regulation of male gonad development (GO:2000020)3.57959057
86cellular response to gonadotropin stimulus (GO:0071371)3.56760934
87positive regulation of prostaglandin secretion (GO:0032308)3.54109914
88ether metabolic process (GO:0018904)3.52771315
89negative regulation of dendrite development (GO:2000171)3.51293140
90response to nitrosative stress (GO:0051409)3.50266702
91placenta development (GO:0001890)3.49463969
92male genitalia development (GO:0030539)3.47548293
93neuroepithelial cell differentiation (GO:0060563)3.47180133
94ketone biosynthetic process (GO:0042181)3.46196552
95spermatid nucleus differentiation (GO:0007289)3.45373798
96branching involved in ureteric bud morphogenesis (GO:0001658)3.44516424
97monoubiquitinated protein deubiquitination (GO:0035520)3.43862125
98metanephros development (GO:0001656)3.42941911
99hemoglobin metabolic process (GO:0020027)3.38069015
100RNA localization (GO:0006403)3.36616598
101RNA destabilization (GO:0050779)3.33324115
102regulation of male gonad development (GO:2000018)3.32066220
103adhesion of symbiont to host cell (GO:0044650)3.31680528
104virion attachment to host cell (GO:0019062)3.31680528
105meiotic cell cycle (GO:0051321)3.25751452
106protein localization to cilium (GO:0061512)3.25276583
107chaperone-mediated protein complex assembly (GO:0051131)3.20868527
108carnitine transport (GO:0015879)3.18366086
109amino-acid betaine transport (GO:0015838)3.18366086
110lactate metabolic process (GO:0006089)3.17519113
111protein polyglutamylation (GO:0018095)3.15717825
112glutathione metabolic process (GO:0006749)3.14195030
113regulation of spindle checkpoint (GO:0090231)3.13605274
114carnitine transmembrane transport (GO:1902603)3.08492085
115sexual reproduction (GO:0019953)3.07990577
116regulation of prostaglandin secretion (GO:0032306)3.06248844
117negative regulation of appetite (GO:0032099)3.05252344
118negative regulation of response to food (GO:0032096)3.05252344
119protein-DNA complex disassembly (GO:0032986)3.04340688
120nucleosome disassembly (GO:0006337)3.04340688
121response to interleukin-4 (GO:0070670)3.01337584
122mitotic sister chromatid cohesion (GO:0007064)2.99587248
123reproductive system development (GO:0061458)2.98613043
124respiratory electron transport chain (GO:0022904)2.98291677
125embryonic axis specification (GO:0000578)2.98098555
126C4-dicarboxylate transport (GO:0015740)2.97915251
127estrogen biosynthetic process (GO:0006703)2.97114955
128electron transport chain (GO:0022900)2.96689530
129response to follicle-stimulating hormone (GO:0032354)2.95424370
130protein K11-linked deubiquitination (GO:0035871)2.90114998
131protein refolding (GO:0042026)2.89599314
132sex differentiation (GO:0007548)2.89594581
133protein-cofactor linkage (GO:0018065)2.88893398
134adhesion of symbiont to host (GO:0044406)2.88471820
135regulation of interferon-gamma biosynthetic process (GO:0045072)2.88371680
136nucleus organization (GO:0006997)2.87824194
137antigen processing and presentation via MHC class Ib (GO:0002475)2.83045030
138positive regulation of icosanoid secretion (GO:0032305)2.78942118
139negative regulation of cAMP-mediated signaling (GO:0043951)2.76851945
140positive regulation of fatty acid transport (GO:2000193)2.73359083
141benzene-containing compound metabolic process (GO:0042537)2.72818231
142DNA deamination (GO:0045006)2.72054816
143xenobiotic catabolic process (GO:0042178)2.69528823
144columnar/cuboidal epithelial cell differentiation (GO:0002065)2.68614242
145replication fork processing (GO:0031297)2.67555487
146lipid translocation (GO:0034204)2.66985145
147phospholipid translocation (GO:0045332)2.66985145
148response to acidic pH (GO:0010447)2.65016358
149negative regulation of organelle assembly (GO:1902116)2.64625701
150serotonin metabolic process (GO:0042428)2.63539851
151response to gonadotropin (GO:0034698)2.58403517
152synapsis (GO:0007129)2.57424375
153meiotic cell cycle process (GO:1903046)2.57223988
154ribosomal small subunit assembly (GO:0000028)2.56904108
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.56825897
156negative regulation of epithelial cell differentiation (GO:0030857)2.55882261
157adaptation of signaling pathway (GO:0023058)2.55189883
158activated T cell proliferation (GO:0050798)2.54774456
159mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.54749576
160androgen metabolic process (GO:0008209)2.52590740
161nuclear pore complex assembly (GO:0051292)2.51533114
162polyamine biosynthetic process (GO:0006596)2.49204931
163protein complex biogenesis (GO:0070271)2.48097814
164negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.46722367
165regulation of cilium assembly (GO:1902017)2.43431139
166mitochondrial fission (GO:0000266)2.42669781
167epithelial cell morphogenesis (GO:0003382)2.41840693
168positive regulation of fatty acid oxidation (GO:0046321)2.41792740
169axoneme assembly (GO:0035082)2.40724320
170positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.39658220
171positive regulation of ERBB signaling pathway (GO:1901186)2.39603573
172single strand break repair (GO:0000012)2.38761453
173otic vesicle formation (GO:0030916)2.35993959
174GTP biosynthetic process (GO:0006183)2.34324906
175centriole assembly (GO:0098534)2.31916585
176mitochondrion degradation (GO:0000422)2.30202078
177gene silencing by RNA (GO:0031047)2.29875699
178glucocorticoid biosynthetic process (GO:0006704)2.29203916
179cell wall macromolecule catabolic process (GO:0016998)13.3155713
180cell wall macromolecule metabolic process (GO:0044036)13.3155713
181regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:000333912.9992211
182fusion of sperm to egg plasma membrane (GO:0007342)12.9214102
183response to parathyroid hormone (GO:0071107)12.2528303
184sperm motility (GO:0030317)11.8973915
185negative regulation of metanephros development (GO:0072217)11.8914826
186acrosome assembly (GO:0001675)11.6536082
187acrosome reaction (GO:0007340)11.2234882
188sperm-egg recognition (GO:0035036)11.0878623
189binding of sperm to zona pellucida (GO:0007339)10.2561117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.67330721
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.52390981
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.18676165
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.17275807
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91526138
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82982653
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.79199647
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74333364
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63951975
10VDR_23849224_ChIP-Seq_CD4+_Human2.52516982
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44305076
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41107343
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.36163739
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.34357070
15TP53_22573176_ChIP-Seq_HFKS_Human2.24101955
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20826395
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19462707
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15196135
19EZH2_22144423_ChIP-Seq_EOC_Human2.14159942
20IGF1R_20145208_ChIP-Seq_DFB_Human2.09576481
21VDR_22108803_ChIP-Seq_LS180_Human2.01125976
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1538183
23EWS_26573619_Chip-Seq_HEK293_Human1.97841469
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97085039
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.95983726
26SCL_19346495_ChIP-Seq_HPC-7_Human1.95750108
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89177592
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76742571
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76192757
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74604416
31IRF1_19129219_ChIP-ChIP_H3396_Human1.74383080
32FOXP3_21729870_ChIP-Seq_TREG_Human1.72817817
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72462590
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70211577
35AR_20517297_ChIP-Seq_VCAP_Human1.69075845
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68856162
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.67032064
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65840891
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.65388034
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.65091402
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.64024229
42ZNF274_21170338_ChIP-Seq_K562_Hela1.63555523
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62679529
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61259603
45MYC_18940864_ChIP-ChIP_HL60_Human1.61083223
46ELK1_19687146_ChIP-ChIP_HELA_Human1.59240694
47STAT1_17558387_ChIP-Seq_HELA_Human1.58961460
48TCF7_22412390_ChIP-Seq_EML_Mouse1.57576224
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56849927
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.56683476
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.55230582
52* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52570295
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52156223
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51617479
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51020419
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.50787350
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50596052
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.49940092
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.49521660
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48058759
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47517480
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46470801
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45850204
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.45684930
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45264492
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44899575
67ER_23166858_ChIP-Seq_MCF-7_Human1.43955293
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43547064
69P53_21459846_ChIP-Seq_SAOS-2_Human1.42937627
70CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38410222
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37326082
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37107735
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35595100
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.34562619
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33726454
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31987952
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31427640
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.30563311
79MYB_26560356_Chip-Seq_TH2_Human1.29733841
80MYB_26560356_Chip-Seq_TH1_Human1.29583101
81GBX2_23144817_ChIP-Seq_PC3_Human1.28347090
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28129158
83TAF15_26573619_Chip-Seq_HEK293_Human1.28092756
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27749249
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25896536
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23695916
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23688049
88BCL6_27268052_Chip-Seq_Bcells_Human1.23534672
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22895348
90NCOR_22424771_ChIP-Seq_293T_Human1.22538346
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22000502
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20055981
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19199439
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19187708
95GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.18466459
96P300_19829295_ChIP-Seq_ESCs_Human1.15965295
97GATA3_27048872_Chip-Seq_THYMUS_Human1.15925824
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15840151
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15735416
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15538366
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14761962
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14685040
103ERG_20517297_ChIP-Seq_VCAP_Human1.14278445
104BCOR_27268052_Chip-Seq_Bcells_Human1.14208912
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.13755916
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13182077
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13178490
108RUNX_20019798_ChIP-Seq_JUKART_Human1.12846458
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.12586789
110SPI1_26923725_Chip-Seq_HPCs_Mouse1.12317503
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.12311595
112SPI1_20517297_ChIP-Seq_HL60_Human1.11950401
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11858498
114* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11319331
115HOXB7_26014856_ChIP-Seq_BT474_Human1.11024340
116CBP_20019798_ChIP-Seq_JUKART_Human1.10550601
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10550601
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.10497972
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10360031
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09604207
121GATA3_26560356_Chip-Seq_TH2_Human1.09034572
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08722278
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08490701
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.08374893
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08089855
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.07547644
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.07392004
128FUS_26573619_Chip-Seq_HEK293_Human1.07170249
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.06399583
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.06144441
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06144441
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05727089
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05638286
134RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05189826
135IRF8_21731497_ChIP-ChIP_J774_Mouse1.05177158
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04819561
137* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04166680
138PHF8_20622854_ChIP-Seq_HELA_Human1.04140399
139* WDR5_24793694_ChIP-Seq_LNCAP_Human1.04115321
140RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03944432
141RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03709902
142GF1_26923725_Chip-Seq_HPCs_Mouse1.03661135
143MAF_26560356_Chip-Seq_TH2_Human1.03438138
144ESET_19884257_ChIP-Seq_ESCs_Mouse1.03025445
145STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02840114
146CTCF_20526341_ChIP-Seq_ESCs_Human1.02594253
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02557747
148* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02295687
149TCF4_23295773_ChIP-Seq_U87_Human1.02257462
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02185592
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.02035965
152* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01469985
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01217583
154CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00973134
155SOX2_19829295_ChIP-Seq_ESCs_Human1.00402724
156NANOG_19829295_ChIP-Seq_ESCs_Human1.00402724
157GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00301194
158RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00271287
159PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99533556
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.99435719
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99158750
162JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97165217
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97103445
164RUNX2_22187159_ChIP-Seq_PCA_Human0.96370584
165NANOG_20526341_ChIP-Seq_ESCs_Human0.95956039
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.95808704
167CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94113398
168* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94044764
169ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94008051
170GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93966122
171ERA_21632823_ChIP-Seq_H3396_Human0.93267677
172STAT3_23295773_ChIP-Seq_U87_Human0.91718271
173GATA3_21878914_ChIP-Seq_MCF-7_Human0.90136059
174SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89931172
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88101446
176CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86281936
177FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84993471
178CDX2_22108803_ChIP-Seq_LS180_Human0.82876803
179CRX_20693478_ChIP-Seq_RETINA_Mouse0.82013813
180OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81014227
181SMAD4_21741376_ChIP-Seq_EPCs_Human0.80859504
182RAC3_21632823_ChIP-Seq_H3396_Human0.80313087
183SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79579950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.23910316
2* MP0001929_abnormal_gametogenesis5.00020504
3MP0003121_genomic_imprinting4.82783025
4MP0008877_abnormal_DNA_methylation3.41211760
5* MP0002210_abnormal_sex_determination3.00656109
6* MP0002161_abnormal_fertility/fecundity2.76298543
7* MP0001145_abnormal_male_reproductive2.69583086
8MP0005670_abnormal_white_adipose2.51198979
9MP0003186_abnormal_redox_activity2.42622819
10MP0001661_extended_life_span2.28357114
11* MP0000653_abnormal_sex_gland2.27241795
12MP0003011_delayed_dark_adaptation2.22628018
13MP0000639_abnormal_adrenal_gland2.13310874
14MP0005410_abnormal_fertilization14.7769293
15MP0003123_paternal_imprinting11.0444264
16MP0008995_early_reproductive_senescence1.95206385
17MP0003646_muscle_fatigue1.83549003
18MP0002837_dystrophic_cardiac_calcinosis1.80857115
19* MP0003936_abnormal_reproductive_system1.71072366
20MP0004808_abnormal_hematopoietic_stem1.63946793
21MP0002102_abnormal_ear_morphology1.62293158
22MP0001545_abnormal_hematopoietic_system1.55667828
23MP0005397_hematopoietic_system_phenotyp1.55667828
24MP0001835_abnormal_antigen_presentation1.53906001
25MP0001727_abnormal_embryo_implantation1.46412534
26MP0009278_abnormal_bone_marrow1.46403879
27MP0000685_abnormal_immune_system1.38965620
28MP0002396_abnormal_hematopoietic_system1.28416111
29MP0008961_abnormal_basal_metabolism1.22952235
30MP0003806_abnormal_nucleotide_metabolis1.22430783
31MP0008007_abnormal_cellular_replicative1.19595294
32MP0008057_abnormal_DNA_replication1.17976622
33MP0005671_abnormal_response_to1.17281462
34MP0003763_abnormal_thymus_physiology1.16712966
35MP0005360_urolithiasis1.16463103
36MP0009785_altered_susceptibility_to1.16035259
37MP0009765_abnormal_xenobiotic_induced1.12257153
38MP0003828_pulmonary_edema1.11815521
39MP0005174_abnormal_tail_pigmentation1.10180538
40MP0002398_abnormal_bone_marrow1.09736319
41MP0004233_abnormal_muscle_weight1.09187870
42MP0005367_renal/urinary_system_phenotyp1.07418860
43MP0000516_abnormal_urinary_system1.07418860
44MP0000750_abnormal_muscle_regeneration1.06361323
45MP0005025_abnormal_response_to1.05852258
46MP0005464_abnormal_platelet_physiology1.03446977
47MP0003866_abnormal_defecation1.02872865
48MP0002723_abnormal_immune_serum1.02740120
49MP0002420_abnormal_adaptive_immunity1.00227422
50MP0001800_abnormal_humoral_immune0.99635665
51MP0001819_abnormal_immune_cell0.98178661
52MP0005332_abnormal_amino_acid0.96251927
53MP0005310_abnormal_salivary_gland0.95239484
54MP0005448_abnormal_energy_balance0.95227327
55MP0001968_abnormal_touch/_nociception0.93124931
56MP0002452_abnormal_antigen_presenting0.92787107
57MP0005551_abnormal_eye_electrophysiolog0.92746223
58MP0001919_abnormal_reproductive_system0.92054457
59MP0006036_abnormal_mitochondrial_physio0.91499401
60* MP0002160_abnormal_reproductive_system0.91459960
61MP0002405_respiratory_system_inflammati0.91352781
62MP0002163_abnormal_gland_morphology0.90946906
63MP0003195_calcinosis0.89762107
64MP0000716_abnormal_immune_system0.89597151
65MP0000689_abnormal_spleen_morphology0.89328720
66MP0005075_abnormal_melanosome_morpholog0.89319974
67MP0003122_maternal_imprinting0.89163168
68MP0003787_abnormal_imprinting0.89047396
69MP0006276_abnormal_autonomic_nervous0.87664890
70MP0002909_abnormal_adrenal_gland0.87044194
71MP0003724_increased_susceptibility_to0.86976699
72MP0001873_stomach_inflammation0.86858105
73MP0003786_premature_aging0.86288057
74MP0001485_abnormal_pinna_reflex0.85925776
75MP0005623_abnormal_meninges_morphology0.84794344
76MP0010094_abnormal_chromosome_stability0.84783904
77MP0000703_abnormal_thymus_morphology0.84341028
78MP0003943_abnormal_hepatobiliary_system0.83566243
79MP0003567_abnormal_fetal_cardiomyocyte0.83513350
80MP0005084_abnormal_gallbladder_morpholo0.82736005
81MP0009672_abnormal_birth_weight0.82413683
82MP0002138_abnormal_hepatobiliary_system0.81958736
83MP0004142_abnormal_muscle_tone0.81513723
84MP0002429_abnormal_blood_cell0.81224608
85MP0002722_abnormal_immune_system0.80311459
86MP0006072_abnormal_retinal_apoptosis0.80012137
87MP0008058_abnormal_DNA_repair0.79381727
88MP0003436_decreased_susceptibility_to0.78716654
89MP0003115_abnormal_respiratory_system0.78447762
90MP0009384_cardiac_valve_regurgitation0.78230804
91MP0001765_abnormal_ion_homeostasis0.78006821
92MP0002148_abnormal_hypersensitivity_rea0.76186882
93MP0001440_abnormal_grooming_behavior0.76087467
94MP0002733_abnormal_thermal_nociception0.75233882
95MP0001986_abnormal_taste_sensitivity0.72207013
96MP0005253_abnormal_eye_physiology0.70873396
97MP0002419_abnormal_innate_immunity0.70806839
98MP0003315_abnormal_perineum_morphology0.70760877
99MP0005000_abnormal_immune_tolerance0.70514272
100MP0005647_abnormal_sex_gland0.70081982
101MP0000627_abnormal_mammary_gland0.68773571
102MP0002332_abnormal_exercise_endurance0.68683985
103MP0002653_abnormal_ependyma_morphology0.68454353
104MP0010386_abnormal_urinary_bladder0.66695985
105MP0004134_abnormal_chest_morphology0.66258623
106MP0008872_abnormal_physiological_respon0.65761924
107MP0005387_immune_system_phenotype0.65269798
108MP0001790_abnormal_immune_system0.65269798
109MP0002282_abnormal_trachea_morphology0.63739579
110MP0002928_abnormal_bile_duct0.62660357
111MP0005266_abnormal_metabolism0.60669545
112MP0002272_abnormal_nervous_system0.60658518
113MP0000313_abnormal_cell_death0.60222447
114MP0005334_abnormal_fat_pad0.59644518
115MP0003045_fibrosis0.59573232
116MP0008875_abnormal_xenobiotic_pharmacok0.59403043
117MP0002735_abnormal_chemical_nociception0.59303265
118MP0008775_abnormal_heart_ventricle0.58161308
119MP0009333_abnormal_splenocyte_physiolog0.58074833
120MP0004215_abnormal_myocardial_fiber0.57566824
121MP0005666_abnormal_adipose_tissue0.57103316
122MP0002132_abnormal_respiratory_system0.56456721
123MP0004145_abnormal_muscle_electrophysio0.56356601
124MP0009745_abnormal_behavioral_response0.56249027
125MP0000372_irregular_coat_pigmentation0.55908000
126MP0003953_abnormal_hormone_level0.55539079
127MP0001502_abnormal_circadian_rhythm0.55386443
128MP0001853_heart_inflammation0.55211708
129MP0005408_hypopigmentation0.55085379
130* MP0005389_reproductive_system_phenotype0.55028669
131MP0009703_decreased_birth_body0.54897937
132MP0008469_abnormal_protein_level0.53155520
133MP0000490_abnormal_crypts_of0.52972990
134MP0006035_abnormal_mitochondrial_morpho0.52715877
135MP0001970_abnormal_pain_threshold0.52687504
136MP0003077_abnormal_cell_cycle0.52442592
137MP0010155_abnormal_intestine_physiology0.52236410
138MP0002277_abnormal_respiratory_mucosa0.52025179
139MP0000358_abnormal_cell_content/0.51579743
140MP0003303_peritoneal_inflammation0.51109043
141MP0001845_abnormal_inflammatory_respons0.51014843
142MP0002019_abnormal_tumor_incidence0.50614575
143MP0003300_gastrointestinal_ulcer0.49699079
144MP0000465_gastrointestinal_hemorrhage0.49238323
145MP0005636_abnormal_mineral_homeostasis0.48519319
146MP0009379_abnormal_foot_pigmentation0.47500826
147MP0000249_abnormal_blood_vessel0.42992673
148MP0003111_abnormal_nucleus_morphology0.41812330
149MP0001764_abnormal_homeostasis0.41031611
150MP0002166_altered_tumor_susceptibility0.39908866
151MP0002234_abnormal_pharynx_morphology0.39655851
152MP0001348_abnormal_lacrimal_gland0.37905739
153MP0009763_increased_sensitivity_to0.36597420
154MP0003448_altered_tumor_morphology0.35664521
155MP0000598_abnormal_liver_morphology0.34693576
156MP0002095_abnormal_skin_pigmentation0.33743459
157MP0010368_abnormal_lymphatic_system0.33276847
158MP0006054_spinal_hemorrhage0.33079306
159MP0004036_abnormal_muscle_relaxation0.32970492
160MP0001119_abnormal_female_reproductive0.32505857
161MP0003183_abnormal_peptide_metabolism0.32424275
162MP0004957_abnormal_blastocyst_morpholog0.31800754
163MP0005319_abnormal_enzyme/_coenzyme0.31689878
164MP0002127_abnormal_cardiovascular_syste0.31583236

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.92216540
2Abnormal respiratory motile cilium morphology (HP:0005938)7.91998621
3Abnormal respiratory epithelium morphology (HP:0012253)7.91998621
4Abnormal hemoglobin (HP:0011902)7.27074419
5Rhinitis (HP:0012384)7.01374040
6Nasal polyposis (HP:0100582)7.00968920
7Infertility (HP:0000789)6.94008373
8Abnormality of male internal genitalia (HP:0000022)6.74224219
9Chronic bronchitis (HP:0004469)6.54566090
10Sex reversal (HP:0012245)6.50227783
11Abnormal sex determination (HP:0012244)6.50227783
12Abnormality of the nasal mucosa (HP:0000433)6.03746207
13Abnormal ciliary motility (HP:0012262)5.87134669
14Abnormality of the heme biosynthetic pathway (HP:0010472)5.85019120
15Hypochromic microcytic anemia (HP:0004840)5.71561721
16Gonadal dysgenesis (HP:0000133)5.16128132
17Bronchitis (HP:0012387)4.81149921
18Male infertility (HP:0003251)4.79548350
19Nephronophthisis (HP:0000090)4.64120202
20Bronchiectasis (HP:0002110)4.52833074
21Papilledema (HP:0001085)4.39304317
22Abnormal spermatogenesis (HP:0008669)4.36236508
23Hypoplasia of the uterus (HP:0000013)4.05481998
24Recurrent sinusitis (HP:0011108)3.69600725
25Recurrent bronchitis (HP:0002837)3.65539141
26Azoospermia (HP:0000027)3.50117961
27Recurrent otitis media (HP:0000403)3.37877813
28Abnormality of the renal medulla (HP:0100957)3.36857259
29Gonadotropin excess (HP:0000837)3.32754936
30Aplasia/hypoplasia of the uterus (HP:0008684)3.32054315
31Toxemia of pregnancy (HP:0100603)3.31190677
32Acute necrotizing encephalopathy (HP:0006965)3.25717281
33Mitochondrial inheritance (HP:0001427)3.14357944
34Pallor (HP:0000980)3.14110920
35Stomatitis (HP:0010280)3.11041506
36True hermaphroditism (HP:0010459)3.03456561
37Molar tooth sign on MRI (HP:0002419)2.99889162
38Abnormality of midbrain morphology (HP:0002418)2.99889162
39Progressive macrocephaly (HP:0004481)2.94753808
40Tubular atrophy (HP:0000092)2.91002964
41Abnormal mitochondria in muscle tissue (HP:0008316)2.90255339
42Pancreatic cysts (HP:0001737)2.89016824
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80791020
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80791020
45Increased CSF lactate (HP:0002490)2.76541254
46Hepatocellular necrosis (HP:0001404)2.73705337
47Conjunctival hamartoma (HP:0100780)2.69941537
48Acute encephalopathy (HP:0006846)2.67597796
49Hypochromic anemia (HP:0001931)2.65673072
50Tubulointerstitial abnormality (HP:0001969)2.61960616
51Increased hepatocellular lipid droplets (HP:0006565)2.56118606
52Renal Fanconi syndrome (HP:0001994)2.54849742
53Short tibia (HP:0005736)2.54425878
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.52589531
55Tubulointerstitial fibrosis (HP:0005576)2.50076290
56Tubulointerstitial nephritis (HP:0001970)2.49036492
57Lipid accumulation in hepatocytes (HP:0006561)2.46992114
58Testicular neoplasm (HP:0010788)2.44729904
59Reticulocytosis (HP:0001923)2.35472376
60Hepatic necrosis (HP:0002605)2.27681194
61Polydipsia (HP:0001959)2.25231248
62Abnormal drinking behavior (HP:0030082)2.25231248
63Abnormal number of erythroid precursors (HP:0012131)2.24117176
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22840658
65Short 4th metacarpal (HP:0010044)2.22840658
66Myositis (HP:0100614)2.19398789
67Renal salt wasting (HP:0000127)2.19375091
68Abnormality of cells of the erythroid lineage (HP:0012130)2.18914500
69Microcytic anemia (HP:0001935)2.17199182
70Type II lissencephaly (HP:0007260)2.17048358
71Deformed sella turcica (HP:0002681)2.12013609
72Pancreatic fibrosis (HP:0100732)2.09833405
73IgG deficiency (HP:0004315)2.09548550
74Impulsivity (HP:0100710)2.07791962
75Mesomelia (HP:0003027)2.07546926
76Absent frontal sinuses (HP:0002688)2.07351544
77Adrenal hypoplasia (HP:0000835)2.05814580
78J-shaped sella turcica (HP:0002680)2.05442069
79Thrombocytosis (HP:0001894)2.01894469
80Abnormality of renal resorption (HP:0011038)2.00488970
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.3229863
82Dynein arm defect of respiratory motile cilia (HP:0012255)11.2250977
83Absent/shortened dynein arms (HP:0200106)11.2250977
84Increased intramyocellular lipid droplets (HP:0012240)1.99425991
85Postaxial foot polydactyly (HP:0001830)1.94699934
86Cholecystitis (HP:0001082)1.94380283
87Abnormal gallbladder physiology (HP:0012438)1.94380283
88Easy fatigability (HP:0003388)1.93668960
89Dyschromatopsia (HP:0007641)1.93516809
90Cerebellar dysplasia (HP:0007033)1.90235537
91Furrowed tongue (HP:0000221)1.90210535
92Stage 5 chronic kidney disease (HP:0003774)1.89100911
93Mesangial abnormality (HP:0001966)1.89015789
94Pustule (HP:0200039)1.87976181
95Abnormality of the renal collecting system (HP:0004742)1.87781482
96Exertional dyspnea (HP:0002875)1.87753195
97Abnormality of reticulocytes (HP:0004312)1.87429734
98Abnormality of DNA repair (HP:0003254)1.87217424
99Abnormality of the renal cortex (HP:0011035)1.86415394
100Optic disc pallor (HP:0000543)1.85711723
101Stenosis of the external auditory canal (HP:0000402)1.85068816
102Inflammation of the large intestine (HP:0002037)1.83000976
103Increased muscle lipid content (HP:0009058)1.81980091
104Hypothermia (HP:0002045)1.81798909
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81537141
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80548536
107Fatigue (HP:0012378)1.79836578
108Gynecomastia (HP:0000771)1.79519173
109Loss of speech (HP:0002371)1.79222648
110Chronic sinusitis (HP:0011109)1.79068735
111Elevated erythrocyte sedimentation rate (HP:0003565)1.78844262
112Abnormality of renal excretion (HP:0011036)1.78171787
113Respiratory failure (HP:0002878)1.77075416
114Hemorrhage of the eye (HP:0011885)1.75013606
115Cerebral edema (HP:0002181)1.74152398
116Type 2 muscle fiber atrophy (HP:0003554)1.74024250
117Gastrointestinal inflammation (HP:0004386)1.73804003
118Congenital hepatic fibrosis (HP:0002612)1.72742510
119Meningioma (HP:0002858)1.72330802
120Abnormality of the neuromuscular junction (HP:0003398)1.70590718
121Fatigable weakness (HP:0003473)1.70590718
122Medial flaring of the eyebrow (HP:0010747)1.69965243
1233-Methylglutaconic aciduria (HP:0003535)1.68407020
124Abnormal rod and cone electroretinograms (HP:0008323)1.67525710
125Bone cyst (HP:0012062)1.66749381
126Hamartoma of the eye (HP:0010568)1.66360997
127Choroideremia (HP:0001139)1.65314404
128Orchitis (HP:0100796)1.63208767
129Retinal dysplasia (HP:0007973)1.62346359
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60867680
131Erythroderma (HP:0001019)1.60676035
132Abnormality of the 4th metacarpal (HP:0010012)1.58517831
133Muscle fiber atrophy (HP:0100295)1.58306543
134Prostate neoplasm (HP:0100787)1.57241243
135Cutaneous melanoma (HP:0012056)1.57034558
136Renal dysplasia (HP:0000110)1.56002672
137Male pseudohermaphroditism (HP:0000037)1.54350268
138Oculomotor apraxia (HP:0000657)1.54176416
139Hematochezia (HP:0002573)1.53062993
140Abnormal hair whorl (HP:0010721)1.53025648
141Abnormality of the sella turcica (HP:0002679)1.53007252
142Cleft eyelid (HP:0000625)1.52272729
143Double outlet right ventricle (HP:0001719)1.52263590
144Congenital malformation of the right heart (HP:0011723)1.52263590
145Nephropathy (HP:0000112)1.52236027
146Colitis (HP:0002583)1.50291791
147Abnormal urine output (HP:0012590)1.50159764
148Abnormality of cochlea (HP:0000375)1.49662668
149Chronic otitis media (HP:0000389)1.49645413
150Gaze-evoked nystagmus (HP:0000640)1.47835479
151Aplastic anemia (HP:0001915)1.47830277
152Episodic fever (HP:0001954)1.47078888
153Cystic liver disease (HP:0006706)1.46978767
154Eosinophilia (HP:0001880)1.46662631
155Decreased central vision (HP:0007663)1.44460841
156Aplasia/Hypoplasia of the spleen (HP:0010451)1.43749289
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.41850776
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.41686635
159Asplenia (HP:0001746)1.40683005
160Lactic acidosis (HP:0003128)1.40554387
161Pancytopenia (HP:0001876)1.40427673
162Abnormality of eosinophils (HP:0001879)1.40145613
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40004470
164Panhypogammaglobulinemia (HP:0003139)1.39117313
165Respiratory difficulties (HP:0002880)1.38497548
166Neurodegeneration (HP:0002180)1.37770346
167Neoplasm of the adrenal cortex (HP:0100641)1.37388017
168Bile duct proliferation (HP:0001408)1.35805808
169Abnormal biliary tract physiology (HP:0012439)1.35805808
170Abnormality of T cell physiology (HP:0011840)1.35758773
171Optic neuritis (HP:0100653)1.35630147
172Retrobulbar optic neuritis (HP:0100654)1.35630147
173Weak cry (HP:0001612)1.35435480
174Heterotopia (HP:0002282)1.34459524
175Short ribs (HP:0000773)1.34182399
176Pulmonary fibrosis (HP:0002206)1.33760197
177Absent epiphyses (HP:0010577)1.33567796
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33567796
179Nonprogressive disorder (HP:0003680)1.33169491
180Polyuria (HP:0000103)1.32686868
181Asymmetric septal hypertrophy (HP:0001670)1.30885528
182Fibular hypoplasia (HP:0003038)1.30437660
183Bulbar palsy (HP:0001283)1.28323163
184Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27573172
185Facial cleft (HP:0002006)1.27552972
186Short thorax (HP:0010306)1.27233421
18711 pairs of ribs (HP:0000878)1.25683753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK18.34165251
2PDK35.37979819
3PDK45.37979819
4PRKD34.74543663
5ICK4.65093812
6FRK4.29379034
7NUAK14.23475442
8PDK23.46861059
9MST43.08296982
10TAOK32.90353240
11ACVR1B2.82058143
12PLK22.81127113
13VRK22.80471740
14TAF12.70862694
15PTK2B2.70362329
16STK382.62349823
17NEK22.59591132
18TNK22.48094699
19EEF2K2.38214646
20ADRBK22.33008111
21BMPR1B2.12555853
22PLK42.09016873
23MAP4K12.06091745
24MYLK2.01786822
25STK161.71862708
26WNK41.61901635
27PKN11.50145524
28CSF1R1.43917698
29STK391.42401418
30ILK1.41813498
31DAPK31.35605712
32MUSK1.34973488
33GRK61.27452834
34TRIM281.27000412
35PDK11.26550415
36WNK31.23336132
37ADRBK11.21000762
38DYRK21.20579095
39DYRK31.19651846
40PASK1.16496172
41GRK11.15945669
42PRKCE1.15703873
43INSRR1.15229884
44CDK81.14773511
45STK241.14568925
46DYRK1B1.11876796
47ITK1.10288470
48IRAK11.04859763
49ZAP701.04609649
50PAK31.04293644
51OXSR10.97547908
52MAP2K60.97501110
53ZAK0.97270168
54MARK30.96768234
55MAPK130.91661834
56PINK10.90827520
57VRK10.90659310
58RIPK10.88858567
59TXK0.86288588
60FGFR20.81754251
61KIT0.80732204
62HIPK20.79729358
63FLT30.78968296
64GRK50.77569654
65TBK10.75285281
66ERN10.74600538
67BTK0.73897497
68PNCK0.73358034
69PRKG10.67946053
70RIPK40.66739693
71JAK30.66145179
72RPS6KA50.66113457
73PDPK10.65869375
74TYRO30.65688780
75STK30.65304707
76PRKCZ0.64516662
77MAP2K30.64042104
78TNIK0.61602450
79MAP3K100.61038465
80TEC0.59352411
81ABL20.59018195
82STK40.58707386
83IRAK40.58668297
84CDK90.58643346
85DYRK1A0.58125301
86PIM10.57692458
87STK38L0.57255755
88IKBKE0.56672712
89TIE10.55158173
90PKN20.54907095
91NME20.54779434
92PRKACA0.54136198
93DAPK20.53824840
94CCNB10.53615852
95TGFBR20.52244784
96TRIB30.52025636
97CLK10.51614422
98WEE10.50591403
99CSNK1A10.50270709
100CHUK0.47406393
101ROCK20.46924172
102ATR0.46879923
103LCK0.46811759
104GRK70.45636468
105PRKD10.44227949
106PAK40.44223184
107TAOK10.44166985
108IRAK20.43935715
109MAPK150.43044750
110PRKACG0.42993385
111TGFBR10.42969674
112PRKCD0.41237264
113CDK40.40449062
114MAPKAPK50.39497554
115WNK10.38714435
116STK100.38114556
117RPS6KA60.37973737
118TESK20.37878939
119LATS10.37754314
120RPS6KB10.37494773
121PIM20.37246264
122TTK0.37155794
123CHEK20.36951184
124SYK0.35901311
125TAOK20.34972764
126PRKCI0.34912323
127FES0.33736087
128PRKCA0.33715893
129EPHB10.33367623
130PAK20.32169525
131PRKG20.30071019
132PRKCQ0.29937295
133NLK0.29844208
134CAMK2B0.29370807
135BRD40.28836658
136SMG10.28670308
137PRKD20.27901061
138CSK0.27543255
139CDK190.27095828
140ATM0.26958004
141MAPKAPK30.26083283
142MTOR0.25784967
143PAK10.24174701
144CAMKK10.23439448
145KDR0.22512925
146IKBKB0.22122935
147MAP3K60.21894947
148HCK0.21546854
149CAMK1G0.20856884
150CHEK10.20291187
151TYK20.18903489
152MAPK40.18198106
153LRRK20.17682753
154RPS6KA40.17626229
155CDK70.17216450
156MARK20.17044772
157PRKAA10.16555647
158EGFR0.15518318
159RPS6KA10.15000900
160LYN0.14831931
161CSNK2A10.14341248
162RPS6KB20.14287030
163CDK60.13848253
164YES10.13384694

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.08249220
2Parkinsons disease_Homo sapiens_hsa050123.47543864
3Fatty acid biosynthesis_Homo sapiens_hsa000613.47246663
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.15408567
5Selenocompound metabolism_Homo sapiens_hsa004502.96024963
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57680272
7Linoleic acid metabolism_Homo sapiens_hsa005912.49032930
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.43787860
9Pyruvate metabolism_Homo sapiens_hsa006202.42756521
10Alzheimers disease_Homo sapiens_hsa050102.38568538
11DNA replication_Homo sapiens_hsa030302.36897041
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34500405
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.20878314
14Glucagon signaling pathway_Homo sapiens_hsa049222.19366466
15Vitamin B6 metabolism_Homo sapiens_hsa007502.11267180
16Protein export_Homo sapiens_hsa030602.09869116
17Antigen processing and presentation_Homo sapiens_hsa046122.09064268
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.07684091
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.87124878
20Fanconi anemia pathway_Homo sapiens_hsa034601.84952681
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80355026
22Primary immunodeficiency_Homo sapiens_hsa053401.80285438
23Propanoate metabolism_Homo sapiens_hsa006401.80056199
24Basal transcription factors_Homo sapiens_hsa030221.78960597
25Nucleotide excision repair_Homo sapiens_hsa034201.78114872
26Ribosome_Homo sapiens_hsa030101.77061857
27Pentose phosphate pathway_Homo sapiens_hsa000301.72303180
28Glycerolipid metabolism_Homo sapiens_hsa005611.70721817
29Hedgehog signaling pathway_Homo sapiens_hsa043401.63956504
30Systemic lupus erythematosus_Homo sapiens_hsa053221.63017004
31B cell receptor signaling pathway_Homo sapiens_hsa046621.58932264
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58919046
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50454002
34Fructose and mannose metabolism_Homo sapiens_hsa000511.50381193
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.45034464
36mRNA surveillance pathway_Homo sapiens_hsa030151.39170999
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33450517
38PPAR signaling pathway_Homo sapiens_hsa033201.31368395
39Olfactory transduction_Homo sapiens_hsa047401.28012334
40Oocyte meiosis_Homo sapiens_hsa041141.25965317
41Purine metabolism_Homo sapiens_hsa002301.22216051
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22082421
43African trypanosomiasis_Homo sapiens_hsa051431.21005693
44Fat digestion and absorption_Homo sapiens_hsa049751.20814600
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18755727
46TGF-beta signaling pathway_Homo sapiens_hsa043501.18711791
47Glutathione metabolism_Homo sapiens_hsa004801.18243832
48Measles_Homo sapiens_hsa051621.15118369
49RNA transport_Homo sapiens_hsa030131.14926770
50RNA polymerase_Homo sapiens_hsa030201.12143242
51Base excision repair_Homo sapiens_hsa034101.12019757
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11215101
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10230329
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.08657870
55Pyrimidine metabolism_Homo sapiens_hsa002401.08578360
56Amphetamine addiction_Homo sapiens_hsa050311.04486567
57Phototransduction_Homo sapiens_hsa047441.04270920
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03036383
59One carbon pool by folate_Homo sapiens_hsa006701.02822537
60Butanoate metabolism_Homo sapiens_hsa006501.02245782
61Nitrogen metabolism_Homo sapiens_hsa009101.01057956
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.00281782
63Herpes simplex infection_Homo sapiens_hsa051680.97597008
64Arachidonic acid metabolism_Homo sapiens_hsa005900.97159768
65Ovarian steroidogenesis_Homo sapiens_hsa049130.95402336
66ABC transporters_Homo sapiens_hsa020100.95194357
67Fatty acid degradation_Homo sapiens_hsa000710.94170816
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92938939
69Collecting duct acid secretion_Homo sapiens_hsa049660.92729790
70Asthma_Homo sapiens_hsa053100.92365050
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.92257173
72Ether lipid metabolism_Homo sapiens_hsa005650.91846439
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91130946
74Legionellosis_Homo sapiens_hsa051340.90494090
75T cell receptor signaling pathway_Homo sapiens_hsa046600.84583073
76Tyrosine metabolism_Homo sapiens_hsa003500.84481266
77Malaria_Homo sapiens_hsa051440.83197403
78Cardiac muscle contraction_Homo sapiens_hsa042600.81987859
79Vitamin digestion and absorption_Homo sapiens_hsa049770.81906671
80Folate biosynthesis_Homo sapiens_hsa007900.80404587
81Osteoclast differentiation_Homo sapiens_hsa043800.79905869
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78195448
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77971339
84RNA degradation_Homo sapiens_hsa030180.77635826
85Acute myeloid leukemia_Homo sapiens_hsa052210.77481946
86Regulation of autophagy_Homo sapiens_hsa041400.75375010
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75097065
88Fatty acid metabolism_Homo sapiens_hsa012120.73892627
89Renin secretion_Homo sapiens_hsa049240.73173268
90Alcoholism_Homo sapiens_hsa050340.73093103
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72536504
92N-Glycan biosynthesis_Homo sapiens_hsa005100.72327559
93Caffeine metabolism_Homo sapiens_hsa002320.68802796
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.65586639
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65374068
96Carbon metabolism_Homo sapiens_hsa012000.65349693
97Dorso-ventral axis formation_Homo sapiens_hsa043200.65095658
98Toxoplasmosis_Homo sapiens_hsa051450.63620071
99Shigellosis_Homo sapiens_hsa051310.63269978
100Tryptophan metabolism_Homo sapiens_hsa003800.63120236
101Influenza A_Homo sapiens_hsa051640.62207363
102Viral carcinogenesis_Homo sapiens_hsa052030.60784380
103Phenylalanine metabolism_Homo sapiens_hsa003600.59100725
104VEGF signaling pathway_Homo sapiens_hsa043700.58959850
105Metabolic pathways_Homo sapiens_hsa011000.58549553
106Salmonella infection_Homo sapiens_hsa051320.58428213
107Chemical carcinogenesis_Homo sapiens_hsa052040.57632786
108Mismatch repair_Homo sapiens_hsa034300.56064821
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56004635
110Fatty acid elongation_Homo sapiens_hsa000620.55369128
111Homologous recombination_Homo sapiens_hsa034400.55363564
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55093763
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53507172
114Retinol metabolism_Homo sapiens_hsa008300.53465618
115Spliceosome_Homo sapiens_hsa030400.53241565
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53133673
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.50755510
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49662402
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49221789
120AMPK signaling pathway_Homo sapiens_hsa041520.49219161
121Huntingtons disease_Homo sapiens_hsa050160.48979905
122Other glycan degradation_Homo sapiens_hsa005110.48856679
123Peroxisome_Homo sapiens_hsa041460.48380249
124Allograft rejection_Homo sapiens_hsa053300.47692262
125Inositol phosphate metabolism_Homo sapiens_hsa005620.47240602
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.46868154
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45873990
128Basal cell carcinoma_Homo sapiens_hsa052170.45742105
129Platelet activation_Homo sapiens_hsa046110.45690870
130Autoimmune thyroid disease_Homo sapiens_hsa053200.45540084
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44371198
132Insulin resistance_Homo sapiens_hsa049310.43655680
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42999635
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42952527
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40611862
136Proteasome_Homo sapiens_hsa030500.40040617
137Hematopoietic cell lineage_Homo sapiens_hsa046400.39089896
138Steroid biosynthesis_Homo sapiens_hsa001000.38602921
139Morphine addiction_Homo sapiens_hsa050320.37989242
140Non-homologous end-joining_Homo sapiens_hsa034500.36321245
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35531551
142Serotonergic synapse_Homo sapiens_hsa047260.35251222
143HIF-1 signaling pathway_Homo sapiens_hsa040660.35133943
144Endocytosis_Homo sapiens_hsa041440.34641553
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32486358
146Sulfur metabolism_Homo sapiens_hsa009200.31541296
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31331818
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31276508
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31225551
150HTLV-I infection_Homo sapiens_hsa051660.31203011
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.30681175
152Nicotine addiction_Homo sapiens_hsa050330.29975822
153Type I diabetes mellitus_Homo sapiens_hsa049400.29687492
154cAMP signaling pathway_Homo sapiens_hsa040240.29429863
155Renin-angiotensin system_Homo sapiens_hsa046140.28660752
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28517874
157Graft-versus-host disease_Homo sapiens_hsa053320.27486534
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26986116

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