INO80B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.49076634
2translational termination (GO:0006415)7.06256390
3ribosomal small subunit biogenesis (GO:0042274)6.50875309
4DNA deamination (GO:0045006)6.20282884
5protein targeting to ER (GO:0045047)6.07690337
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.04933034
7ribosomal small subunit assembly (GO:0000028)6.02108802
8cotranslational protein targeting to membrane (GO:0006613)5.98919267
9translational elongation (GO:0006414)5.94338447
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.76699441
11protein localization to endoplasmic reticulum (GO:0070972)5.73348820
12viral life cycle (GO:0019058)5.60805259
13cellular protein complex disassembly (GO:0043624)5.27797533
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.23712831
15translational initiation (GO:0006413)5.01789536
16maturation of SSU-rRNA (GO:0030490)4.78945083
17protein complex disassembly (GO:0043241)4.72492831
18macromolecular complex disassembly (GO:0032984)4.35721939
19mannose metabolic process (GO:0006013)4.12211608
20protein targeting to membrane (GO:0006612)4.02170078
21nuclear-transcribed mRNA catabolic process (GO:0000956)3.83311002
22mRNA catabolic process (GO:0006402)3.63366926
23translation (GO:0006412)3.62253242
24pentose metabolic process (GO:0019321)3.58700053
25thymic T cell selection (GO:0045061)3.58382907
26modulation by virus of host process (GO:0019054)3.54362388
27tolerance induction (GO:0002507)3.53861286
28RNA catabolic process (GO:0006401)3.45047129
29positive thymic T cell selection (GO:0045059)3.44953598
30modulation by symbiont of host cellular process (GO:0044068)3.40940249
31ribosomal large subunit biogenesis (GO:0042273)3.38883963
32heme biosynthetic process (GO:0006783)3.28491906
333-UTR-mediated mRNA stabilization (GO:0070935)3.28172925
34response to muramyl dipeptide (GO:0032495)3.24306940
35ribonucleoprotein complex biogenesis (GO:0022613)3.09892312
36heme metabolic process (GO:0042168)3.08641435
37apoptotic process involved in morphogenesis (GO:0060561)3.08318162
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.07377994
39telomere maintenance via semi-conservative replication (GO:0032201)3.05365241
40response to peptidoglycan (GO:0032494)3.03522545
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00248925
42negative regulation of cell killing (GO:0031342)3.00248925
43DNA strand elongation involved in DNA replication (GO:0006271)2.99832842
44modulation by symbiont of host immune response (GO:0052553)2.91801436
45positive regulation by symbiont of host defense response (GO:0052509)2.91801436
46modulation by symbiont of host defense response (GO:0052031)2.91801436
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91801436
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91801436
49positive regulation by organism of defense response of other organism involved in symbiotic interact2.91801436
50T cell selection (GO:0045058)2.91171720
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90759178
52granulocyte differentiation (GO:0030851)2.90753565
53NIK/NF-kappaB signaling (GO:0038061)2.87248275
54regulation of histone H3-K27 methylation (GO:0061085)2.86340492
55embryonic process involved in female pregnancy (GO:0060136)2.85356025
56regulation of gamma-delta T cell activation (GO:0046643)2.85022788
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84420135
58regulation of T-helper 2 cell differentiation (GO:0045628)2.84133686
59leukocyte aggregation (GO:0070486)2.83263744
60platelet dense granule organization (GO:0060155)2.82813780
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82487491
62megakaryocyte development (GO:0035855)2.79522794
63protein localization to endosome (GO:0036010)2.78908564
64response to laminar fluid shear stress (GO:0034616)2.78689942
65axonemal dynein complex assembly (GO:0070286)2.78558020
66central nervous system myelination (GO:0022010)2.78490609
67axon ensheathment in central nervous system (GO:0032291)2.78490609
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77810359
69pseudouridine synthesis (GO:0001522)2.77713630
70establishment of protein localization to membrane (GO:0090150)2.76642863
71negative regulation of erythrocyte differentiation (GO:0045647)2.76442188
72DNA strand elongation (GO:0022616)2.75942410
73ncRNA 3-end processing (GO:0043628)2.74347302
74activation of MAPKKK activity (GO:0000185)2.73963279
75UTP biosynthetic process (GO:0006228)2.73600187
76GTP biosynthetic process (GO:0006183)2.73294320
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72669095
78histone H4 deacetylation (GO:0070933)2.72341356
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71190003
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71190003
81rRNA processing (GO:0006364)2.70328407
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69546215
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67180192
84regulation of response to osmotic stress (GO:0047484)2.66241501
85germinal center formation (GO:0002467)2.65994786
86proline metabolic process (GO:0006560)2.65863755
87proline biosynthetic process (GO:0006561)2.65336764
88negative regulation of cell size (GO:0045792)2.63522848
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63064060
90formation of translation preinitiation complex (GO:0001731)2.62884231
91pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62758052
92CTP metabolic process (GO:0046036)2.61765137
93CTP biosynthetic process (GO:0006241)2.61765137
94UTP metabolic process (GO:0046051)2.61449285
95negative thymic T cell selection (GO:0045060)2.61356403
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60257731
97cellular component biogenesis (GO:0044085)2.58503523
98DNA replication initiation (GO:0006270)2.58287578
99activation of JUN kinase activity (GO:0007257)2.57725376
100CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.57559902
101protein targeting (GO:0006605)2.57553064
102rRNA metabolic process (GO:0016072)2.57425170
103detection of bacterium (GO:0016045)2.57152180
104positive T cell selection (GO:0043368)2.55832700
105regulation of gamma-delta T cell differentiation (GO:0045586)2.55304769
106histone H3 deacetylation (GO:0070932)2.55132622
107pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.54322509
108positive regulation of extracellular matrix organization (GO:1903055)2.53632487
109DNA unwinding involved in DNA replication (GO:0006268)2.53259940
110negative regulation of interleukin-2 production (GO:0032703)2.53257196
111regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50967313
112cellular response to virus (GO:0098586)2.50406097
113endothelial cell chemotaxis (GO:0035767)2.50378193
114positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50128211
115detection of other organism (GO:0098543)2.49506089
116nuclear envelope reassembly (GO:0031468)2.49438087
117mitotic nuclear envelope reassembly (GO:0007084)2.49438087
118establishment of protein localization to organelle (GO:0072594)2.48482836
119COPI coating of Golgi vesicle (GO:0048205)2.48009954
120Golgi transport vesicle coating (GO:0048200)2.48009954
121definitive hemopoiesis (GO:0060216)2.46350766
122regulation of extracellular matrix disassembly (GO:0010715)2.45977610
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45091744
124porphyrin-containing compound biosynthetic process (GO:0006779)2.44809572
125negative regulation of RNA splicing (GO:0033119)2.44511606
126regulation of monocyte differentiation (GO:0045655)2.43617737
127pentose-phosphate shunt (GO:0006098)2.43166556
128L-serine metabolic process (GO:0006563)2.42435936
129regulation of ARF protein signal transduction (GO:0032012)2.41101293
130macrophage activation involved in immune response (GO:0002281)2.41010705
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40634852
132regulation of ARF GTPase activity (GO:0032312)2.39926073
133neutrophil activation involved in immune response (GO:0002283)2.39257512
134negative regulation of myotube differentiation (GO:0010832)2.38977974
135positive regulation of gamma-delta T cell activation (GO:0046645)2.38817374
136negative regulation of phagocytosis (GO:0050765)2.38754976
137proteasome assembly (GO:0043248)2.38353000
138negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.38071840
139signal complex assembly (GO:0007172)2.38003330
140nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36632475
141axoneme assembly (GO:0035082)2.36606291
142cilium movement (GO:0003341)2.36282608
143hypotonic response (GO:0006971)2.36233131
144negative T cell selection (GO:0043383)2.36055624
145regulation of chromatin binding (GO:0035561)2.35916121
146positive regulation of histone deacetylation (GO:0031065)2.35575104
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34621366
148endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34067595
149response to interferon-beta (GO:0035456)2.33894895
150porphyrin-containing compound metabolic process (GO:0006778)2.32833529
151heme transport (GO:0015886)2.32803498
152exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32625810
153telomere maintenance via recombination (GO:0000722)2.32285636
154regulation of interleukin-2 biosynthetic process (GO:0045076)2.32257372
155negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31707169
156intracellular estrogen receptor signaling pathway (GO:0030520)2.31115048
157viral mRNA export from host cell nucleus (GO:0046784)2.30388434
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.30361470
159positive regulation by host of viral transcription (GO:0043923)2.29352459
160retinoic acid receptor signaling pathway (GO:0048384)2.28534149
161amyloid precursor protein catabolic process (GO:0042987)2.28267616
162negative regulation of granulocyte differentiation (GO:0030853)2.27169905
163negative regulation of leukocyte mediated immunity (GO:0002704)2.25461359
164maternal placenta development (GO:0001893)2.25252429
165nucleotide-excision repair, DNA gap filling (GO:0006297)2.24959471
166energy coupled proton transport, down electrochemical gradient (GO:0015985)2.24831969
167ATP synthesis coupled proton transport (GO:0015986)2.24831969
168myeloid dendritic cell differentiation (GO:0043011)2.24584627
169regulation of superoxide anion generation (GO:0032928)2.23548471
170negative regulation of lymphocyte mediated immunity (GO:0002707)2.23502801
171motile cilium assembly (GO:0044458)2.23501741
172viral protein processing (GO:0019082)2.23251226
173regulation of glucose import in response to insulin stimulus (GO:2001273)2.23224105
174antigen processing and presentation of endogenous antigen (GO:0019883)2.23046360
175B cell receptor signaling pathway (GO:0050853)2.22872993
176regulation of NFAT protein import into nucleus (GO:0051532)2.22780904
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.22656382
178activation of Rac GTPase activity (GO:0032863)2.22124713
179positive regulation of keratinocyte differentiation (GO:0045618)2.22093951
180negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22087308
181retrograde transport, endosome to Golgi (GO:0042147)2.21157471
182negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.20007260
183metallo-sulfur cluster assembly (GO:0031163)2.19607011
184iron-sulfur cluster assembly (GO:0016226)2.19607011
185pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.19343429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.37839096
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58330528
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.17578836
4E2F7_22180533_ChIP-Seq_HELA_Human2.98977914
5VDR_21846776_ChIP-Seq_THP-1_Human2.93672028
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.77263706
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.60074285
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52854779
9SCL_19346495_ChIP-Seq_HPC-7_Human2.48068196
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28065374
11TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26561722
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22762231
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21408298
14KDM2B_26808549_Chip-Seq_DND41_Human2.21399624
15RACK7_27058665_Chip-Seq_MCF-7_Human2.17125314
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16268322
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14938065
18MYC_22102868_ChIP-Seq_BL_Human2.11029550
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07926758
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06444368
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05980399
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05090788
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02126546
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00715453
25* ETS1_20019798_ChIP-Seq_JURKAT_Human1.98482662
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94850055
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94258141
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.90275736
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81989717
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.80898932
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79464108
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78741406
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77894803
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76735423
35VDR_24763502_ChIP-Seq_THP-1_Human1.75819196
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75306358
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73703380
38XRN2_22483619_ChIP-Seq_HELA_Human1.71690410
39P68_20966046_ChIP-Seq_HELA_Human1.70965170
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.67251622
41MAF_26560356_Chip-Seq_TH1_Human1.66582968
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.65380817
43* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65164585
44ZNF263_19887448_ChIP-Seq_K562_Human1.64303384
45KDM2B_26808549_Chip-Seq_K562_Human1.63051389
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61980304
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.61241664
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59447109
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.59327018
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.56396328
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52010427
52* VDR_23849224_ChIP-Seq_CD4+_Human1.51297681
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.49539619
54SMC4_20622854_ChIP-Seq_HELA_Human1.49249980
55UTX_26944678_Chip-Seq_JUKART_Human1.48650395
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46967785
57LXR_22292898_ChIP-Seq_THP-1_Human1.45375238
58MAF_26560356_Chip-Seq_TH2_Human1.44685090
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44596802
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43331190
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.40685692
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38023134
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37992014
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37588394
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36719076
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.35870368
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34707872
68CREB1_26743006_Chip-Seq_LNCaP_Human1.34517120
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34464276
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34453596
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34353520
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33918972
73* YY1_21170310_ChIP-Seq_MESCs_Mouse1.32948910
74TCF7_22412390_ChIP-Seq_EML_Mouse1.32870375
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30713005
76SPI1_23547873_ChIP-Seq_NB4_Human1.30564525
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.30365258
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28727801
79STAT1_20625510_ChIP-Seq_HELA_Human1.28554197
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27254134
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27224956
82NCOR1_26117541_ChIP-Seq_K562_Human1.26987596
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26485029
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.25930318
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25774007
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25668880
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25489622
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25245805
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24744832
90CIITA_25753668_ChIP-Seq_RAJI_Human1.24728047
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24047787
92BCL6_27268052_Chip-Seq_Bcells_Human1.23957371
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23808895
94DCP1A_22483619_ChIP-Seq_HELA_Human1.23737410
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23235823
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22868016
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22301255
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21932583
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20917310
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.20264317
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20181175
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20142751
103* GABP_19822575_ChIP-Seq_HepG2_Human1.19771589
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18303539
105FOXP3_21729870_ChIP-Seq_TREG_Human1.17930022
106TTF2_22483619_ChIP-Seq_HELA_Human1.17789725
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17200843
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16827893
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16670104
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16440398
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16307273
112* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15557555
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.15541703
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15487284
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15367449
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15049840
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14830876
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.14587835
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14487406
120MYB_26560356_Chip-Seq_TH1_Human1.13809910
121SA1_27219007_Chip-Seq_ERYTHROID_Human1.13324575
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13084035
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12618150
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12503926
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12338791
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11943181
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11819435
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11500120
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11412651
130TP53_22127205_ChIP-Seq_IMR90_Human1.11330766
131THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10937464
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10543754
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10284901
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10125676
135ATF3_27146783_Chip-Seq_COLON_Human1.09630144
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.08680095
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07433311
138E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07428802
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07249981
140P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06726818
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06454893
142BCOR_27268052_Chip-Seq_Bcells_Human1.05932624
143CTCF_21964334_Chip-Seq_Bcells_Human1.05550409
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05033389
145MYB_26560356_Chip-Seq_TH2_Human1.05007172
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04785758
147NOTCH1_21737748_ChIP-Seq_TLL_Human1.04603349
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04421046
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03648333
150KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03402637
151SPI1_23127762_ChIP-Seq_K562_Human1.03288497
152RXR_22158963_ChIP-Seq_LIVER_Mouse1.02637490
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01717789
154PHF8_20622854_ChIP-Seq_HELA_Human1.01310844
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01003214
156MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00857366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy3.30608938
2MP0000685_abnormal_immune_system2.82782494
3MP0003705_abnormal_hypodermis_morpholog2.71767097
4MP0003172_abnormal_lysosome_physiology2.68324588
5MP0002132_abnormal_respiratory_system2.54137304
6MP0004381_abnormal_hair_follicle2.43741863
7MP0003656_abnormal_erythrocyte_physiolo2.38509572
8MP0005076_abnormal_cell_differentiation2.35524190
9MP0001545_abnormal_hematopoietic_system2.31858226
10MP0005397_hematopoietic_system_phenotyp2.31858226
11MP0003763_abnormal_thymus_physiology2.23971477
12MP0009379_abnormal_foot_pigmentation2.23571164
13MP0002396_abnormal_hematopoietic_system2.14338386
14MP0005075_abnormal_melanosome_morpholog2.06202444
15MP0001835_abnormal_antigen_presentation2.03237162
16MP0009278_abnormal_bone_marrow1.95958680
17MP0002398_abnormal_bone_marrow1.95924091
18MP0001800_abnormal_humoral_immune1.92868543
19MP0003136_yellow_coat_color1.89128531
20MP0005671_abnormal_response_to1.89039536
21MP0005451_abnormal_body_composition1.88877384
22MP0005025_abnormal_response_to1.88069134
23MP0003436_decreased_susceptibility_to1.87362273
24MP0000689_abnormal_spleen_morphology1.80712134
25MP0002139_abnormal_hepatobiliary_system1.80090884
26MP0009785_altered_susceptibility_to1.79648233
27MP0003806_abnormal_nucleotide_metabolis1.79256081
28MP0002405_respiratory_system_inflammati1.78160492
29MP0000678_abnormal_parathyroid_gland1.77341991
30MP0002723_abnormal_immune_serum1.77049216
31MP0009333_abnormal_splenocyte_physiolog1.75593755
32MP0000490_abnormal_crypts_of1.73175392
33MP0002420_abnormal_adaptive_immunity1.71706392
34MP0001873_stomach_inflammation1.71430738
35MP0009840_abnormal_foam_cell1.71239366
36MP0005083_abnormal_biliary_tract1.70908116
37MP0002722_abnormal_immune_system1.70408621
38MP0005000_abnormal_immune_tolerance1.67674286
39MP0001849_ear_inflammation1.67413137
40MP0003191_abnormal_cellular_cholesterol1.66903704
41MP0001819_abnormal_immune_cell1.66206079
42MP0005464_abnormal_platelet_physiology1.65689704
43MP0002452_abnormal_antigen_presenting1.65327706
44MP0000858_altered_metastatic_potential1.64833465
45MP0000716_abnormal_immune_system1.64724202
46MP0005387_immune_system_phenotype1.63557018
47MP0001790_abnormal_immune_system1.63557018
48MP0003300_gastrointestinal_ulcer1.62335665
49MP0002877_abnormal_melanocyte_morpholog1.59885557
50MP0004185_abnormal_adipocyte_glucose1.57628025
51MP0006082_CNS_inflammation1.55792995
52MP0002429_abnormal_blood_cell1.55305383
53MP0002796_impaired_skin_barrier1.50412935
54MP0000465_gastrointestinal_hemorrhage1.48781733
55MP0002166_altered_tumor_susceptibility1.45368424
56MP0003724_increased_susceptibility_to1.41328832
57MP0000703_abnormal_thymus_morphology1.41153231
58MP0003693_abnormal_embryo_hatching1.38679133
59MP0003866_abnormal_defecation1.38388561
60MP0005174_abnormal_tail_pigmentation1.37134164
61MP0005085_abnormal_gallbladder_physiolo1.34244626
62MP0008057_abnormal_DNA_replication1.33624574
63MP0008875_abnormal_xenobiotic_pharmacok1.32666333
64MP0002148_abnormal_hypersensitivity_rea1.32469645
65MP0010155_abnormal_intestine_physiology1.31256238
66MP0003091_abnormal_cell_migration1.30798593
67MP0001533_abnormal_skeleton_physiology1.30491120
68MP0001348_abnormal_lacrimal_gland1.29521942
69MP0002653_abnormal_ependyma_morphology1.28288503
70MP0005409_darkened_coat_color1.27235231
71MP0005666_abnormal_adipose_tissue1.27057041
72MP0002419_abnormal_innate_immunity1.25206355
73MP0003186_abnormal_redox_activity1.24879328
74MP0005310_abnormal_salivary_gland1.24499941
75MP0000733_abnormal_muscle_development1.22748545
76MP0003566_abnormal_cell_adhesion1.21530405
77MP0004808_abnormal_hematopoietic_stem1.19015807
78MP0005365_abnormal_bile_salt1.18843221
79MP0001853_heart_inflammation1.18747694
80MP0004510_myositis1.17343193
81MP0005360_urolithiasis1.15919394
82MP0005410_abnormal_fertilization1.14949934
83MP0002019_abnormal_tumor_incidence1.14219817
84MP0008469_abnormal_protein_level1.14169040
85MP0004957_abnormal_blastocyst_morpholog1.14093807
86MP0004858_abnormal_nervous_system1.13980945
87MP0003329_amyloid_beta_deposits1.13624389
88MP0005375_adipose_tissue_phenotype1.13108679
89MP0002998_abnormal_bone_remodeling1.11869051
90MP0003303_peritoneal_inflammation1.08504905
91MP0001845_abnormal_inflammatory_respons1.07715846
92MP0003075_altered_response_to1.06895093
93MP0005377_hearing/vestibular/ear_phenot1.06653814
94MP0003878_abnormal_ear_physiology1.06653814
95MP0003111_abnormal_nucleus_morphology1.06567047
96MP0004947_skin_inflammation1.04308724
97MP0000920_abnormal_myelination1.02946201
98MP0008995_early_reproductive_senescence1.02916046
99MP0003279_aneurysm1.02609038
100MP0001851_eye_inflammation1.02126139
101MP0002060_abnormal_skin_morphology1.00898427
102MP0000003_abnormal_adipose_tissue0.99709739
103MP0009931_abnormal_skin_appearance0.99388852
104MP0003077_abnormal_cell_cycle0.98572773
105MP0003828_pulmonary_edema0.98016836
106MP0001216_abnormal_epidermal_layer0.96364612
107MP0008961_abnormal_basal_metabolism0.94270028
108MP0001958_emphysema0.94050827
109MP0003453_abnormal_keratinocyte_physiol0.93678003
110MP0006036_abnormal_mitochondrial_physio0.91803585
111MP0005058_abnormal_lysosome_morphology0.91445823
112MP0000313_abnormal_cell_death0.90122059
113MP0001727_abnormal_embryo_implantation0.89614018
114MP0004147_increased_porphyrin_level0.86399089
115MP0003283_abnormal_digestive_organ0.85288274
116MP0005621_abnormal_cell_physiology0.84941556
117MP0002249_abnormal_larynx_morphology0.84739605
118MP0005390_skeleton_phenotype0.83787615
119MP0005023_abnormal_wound_healing0.83208463
120MP0010094_abnormal_chromosome_stability0.83066965
121MP0010352_gastrointestinal_tract_polyps0.82881113
122MP0008932_abnormal_embryonic_tissue0.81342595
123MP0001663_abnormal_digestive_system0.81120748
124MP0003786_premature_aging0.79741474
125MP0000477_abnormal_intestine_morphology0.79416719
126MP0000604_amyloidosis0.78849604
127MP0003011_delayed_dark_adaptation0.77469357
128MP0005636_abnormal_mineral_homeostasis0.77443331
129MP0000609_abnormal_liver_physiology0.76463589
130MP0000681_abnormal_thyroid_gland0.76456026
131MP0005501_abnormal_skin_physiology0.75517118
132MP0005319_abnormal_enzyme/_coenzyme0.73108103
133MP0002933_joint_inflammation0.72657573
134MP0001666_abnormal_nutrient_absorption0.72257212
135MP0005381_digestive/alimentary_phenotyp0.70767698
136MP0000598_abnormal_liver_morphology0.70587285
137MP0000613_abnormal_salivary_gland0.70435784
138MP0000750_abnormal_muscle_regeneration0.69565795
139MP0002089_abnormal_postnatal_growth/wei0.68694406
140MP0002098_abnormal_vibrissa_morphology0.67845619
141MP0002006_tumorigenesis0.67794197

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.32411117
2Abnormal number of erythroid precursors (HP:0012131)6.12439345
3Reticulocytopenia (HP:0001896)4.40725548
4Nasal polyposis (HP:0100582)4.14032127
5Abnormality of the nasal mucosa (HP:0000433)3.77464476
6Abnormal ciliary motility (HP:0012262)3.67261371
7Obstructive sleep apnea (HP:0002870)3.66382642
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65704160
9Macrocytic anemia (HP:0001972)3.62471717
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.61705805
11Petechiae (HP:0000967)3.57931443
12Abnormal respiratory motile cilium morphology (HP:0005938)3.54776454
13Abnormal respiratory epithelium morphology (HP:0012253)3.54776454
14Pallor (HP:0000980)3.54258390
15Abnormal respiratory motile cilium physiology (HP:0012261)3.42371108
16Exertional dyspnea (HP:0002875)3.40918277
17Increased intramyocellular lipid droplets (HP:0012240)3.25314799
18Increased hepatocellular lipid droplets (HP:0006565)3.21159899
19Pustule (HP:0200039)3.15910229
20Eczematoid dermatitis (HP:0000976)3.14747684
21Broad face (HP:0000283)3.03180049
22Lipid accumulation in hepatocytes (HP:0006561)3.02489903
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.01164119
24Hyperacusis (HP:0010780)2.99067295
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98811410
26Thrombocytosis (HP:0001894)2.96611020
27Increased muscle lipid content (HP:0009058)2.95929501
28Renal Fanconi syndrome (HP:0001994)2.93331088
29Recurrent bacterial skin infections (HP:0005406)2.92355807
30Colitis (HP:0002583)2.87801360
31Prolonged bleeding time (HP:0003010)2.83727447
32Elevated erythrocyte sedimentation rate (HP:0003565)2.81932503
33IgM deficiency (HP:0002850)2.80751989
34Recurrent sinusitis (HP:0011108)2.80724741
35Rhinitis (HP:0012384)2.79912917
36Recurrent bronchitis (HP:0002837)2.74980479
37Chronic otitis media (HP:0000389)2.70398922
38Increased serum ferritin (HP:0003281)2.69323426
39Abnormality of reticulocytes (HP:0004312)2.63132826
40Asplenia (HP:0001746)2.61362713
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59965087
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59965087
43Chronic sinusitis (HP:0011109)2.59111744
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57789849
45Bronchiectasis (HP:0002110)2.56462332
46Distal lower limb muscle weakness (HP:0009053)2.55992301
47Hypochromic anemia (HP:0001931)2.55771264
48Achilles tendon contracture (HP:0001771)2.55725262
49Vertebral compression fractures (HP:0002953)2.54376495
50Mitochondrial inheritance (HP:0001427)2.51875072
51Increased IgE level (HP:0003212)2.50593708
52Microcytic anemia (HP:0001935)2.49913997
53Abnormality of the fingertips (HP:0001211)2.49112869
54Epistaxis (HP:0000421)2.48382966
55Stridor (HP:0010307)2.43893476
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.43076566
57Hepatocellular necrosis (HP:0001404)2.40745240
58Distal lower limb amyotrophy (HP:0008944)2.40486903
59Atelectasis (HP:0100750)2.39448456
60Distal upper limb amyotrophy (HP:0007149)2.39416490
61Upper limb amyotrophy (HP:0009129)2.39416490
62Thin bony cortex (HP:0002753)2.39305875
63Poikiloderma (HP:0001029)2.38197178
64Interstitial pulmonary disease (HP:0006530)2.34237496
65Abnormality of iron homeostasis (HP:0011031)2.34098899
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.32348751
67Abnormality of T cell physiology (HP:0011840)2.31658631
68Abnormality of the Achilles tendon (HP:0005109)2.30375892
69Bronchitis (HP:0012387)2.30076518
70Concave nail (HP:0001598)2.28144095
71Increased connective tissue (HP:0009025)2.26708295
72Acanthocytosis (HP:0001927)2.23929360
73Purpura (HP:0000979)2.22960381
74Polygenic inheritance (HP:0010982)2.17310989
75Absent/shortened dynein arms (HP:0200106)2.15816824
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.15816824
773-Methylglutaconic aciduria (HP:0003535)2.14682036
78Short nail (HP:0001799)2.12460044
79Gastrointestinal inflammation (HP:0004386)2.11980789
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10792951
81Abnormality of the thoracic spine (HP:0100711)2.10713683
82Hepatic necrosis (HP:0002605)2.09884558
83Gastrointestinal infarctions (HP:0005244)2.09870653
84Cervical subluxation (HP:0003308)2.09396094
85Nuclear cataract (HP:0100018)2.09089327
86Cellulitis (HP:0100658)2.08648124
87Dysostosis multiplex (HP:0000943)2.07788435
88Chronic obstructive pulmonary disease (HP:0006510)2.07076896
89Obstructive lung disease (HP:0006536)2.07076896
90Abnormality of T cells (HP:0002843)2.06010721
91Abnormal platelet function (HP:0011869)2.05726126
92Impaired platelet aggregation (HP:0003540)2.05726126
93Gingivitis (HP:0000230)2.05428271
94Ragged-red muscle fibers (HP:0003200)2.05175978
95Myositis (HP:0100614)2.04911539
96Inflammation of the large intestine (HP:0002037)2.04885581
97Flat acetabular roof (HP:0003180)2.03192093
98Acute necrotizing encephalopathy (HP:0006965)2.03041601
99J-shaped sella turcica (HP:0002680)2.02391359
100Aplastic anemia (HP:0001915)2.00997349
101Cerebral aneurysm (HP:0004944)2.00468605
102Reticulocytosis (HP:0001923)2.00463411
103Recurrent skin infections (HP:0001581)2.00214159
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.99098338
105Meningitis (HP:0001287)1.98270185
106Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97035267
107Panhypogammaglobulinemia (HP:0003139)1.96857825
108Acute encephalopathy (HP:0006846)1.96679947
109Loss of speech (HP:0002371)1.96294814
110Abnormality of macrophages (HP:0004311)1.95565840
111Thoracic kyphosis (HP:0002942)1.95349675
112Abnormality of transition element cation homeostasis (HP:0011030)1.93566635
113Hypertensive crisis (HP:0100735)1.93564628
114Axonal loss (HP:0003447)1.91636728
115Emphysema (HP:0002097)1.90363063
116Protrusio acetabuli (HP:0003179)1.89591345
117Difficulty climbing stairs (HP:0003551)1.89573118
118Parakeratosis (HP:0001036)1.89213203
119Increased cerebral lipofuscin (HP:0011813)1.89089507
120Intrahepatic cholestasis (HP:0001406)1.87961649
121Abnormality of the aortic arch (HP:0012303)1.87783393
122Abnormal platelet volume (HP:0011876)1.86968779
123Abnormal mitochondria in muscle tissue (HP:0008316)1.86858775
124Mitral regurgitation (HP:0001653)1.86748066
125IgG deficiency (HP:0004315)1.86462280
126Hand muscle atrophy (HP:0009130)1.86350197
127Poikilocytosis (HP:0004447)1.85848476
128Respiratory difficulties (HP:0002880)1.85641302
129Recurrent otitis media (HP:0000403)1.85241519
130Abnormal hemoglobin (HP:0011902)1.85047250
131Increased variability in muscle fiber diameter (HP:0003557)1.84993847
132Diaphragmatic weakness (HP:0009113)1.84809438
133Broad distal phalanx of finger (HP:0009836)1.84284311
134Gastrointestinal stroma tumor (HP:0100723)1.83126481
135Muscle fiber atrophy (HP:0100295)1.83036628
136Long palpebral fissure (HP:0000637)1.82029520
137Neuronal loss in central nervous system (HP:0002529)1.81907558
138Segmental peripheral demyelination/remyelination (HP:0003481)1.81873070
139Basal cell carcinoma (HP:0002671)1.81238799
140Ulnar bowing (HP:0003031)1.81078585
141Seborrheic dermatitis (HP:0001051)1.80963356
142Prolonged partial thromboplastin time (HP:0003645)1.80723221
143Hyperbilirubinemia (HP:0002904)1.79788951
144Spontaneous hematomas (HP:0007420)1.78186906
145Recurrent abscess formation (HP:0002722)1.77385112
146Exercise intolerance (HP:0003546)1.77211025
147Biconcave vertebral bodies (HP:0004586)1.75846008
148Supranuclear gaze palsy (HP:0000605)1.75608427
149Myopathic facies (HP:0002058)1.74762050
150Recurrent fungal infections (HP:0002841)1.74448333
151Increased CSF lactate (HP:0002490)1.74312164
152Agammaglobulinemia (HP:0004432)1.73871289
153Insomnia (HP:0100785)1.72971644
154Syringomyelia (HP:0003396)1.72446397
155Spinal cord lesions (HP:0100561)1.72446397
156Mediastinal lymphadenopathy (HP:0100721)1.71524643
157Vacuolated lymphocytes (HP:0001922)1.71345853
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71180936
159Easy fatigability (HP:0003388)1.71130479
160Dislocated radial head (HP:0003083)1.70478979
161Spastic paraparesis (HP:0002313)1.70417668
162Increased serum lactate (HP:0002151)1.70328723
163Severe combined immunodeficiency (HP:0004430)1.70302856
164Recurrent viral infections (HP:0004429)1.70146574
165Esophageal neoplasm (HP:0100751)1.69663915
166Neoplasm of head and neck (HP:0012288)1.69663915
167Growth hormone excess (HP:0000845)1.69036160
168Microvesicular hepatic steatosis (HP:0001414)1.67485976
169Sparse lateral eyebrow (HP:0005338)1.65999250
170Hemorrhage of the eye (HP:0011885)1.64692483
171Foot dorsiflexor weakness (HP:0009027)1.64418096
172Abnormal gallbladder physiology (HP:0012438)1.64039905
173Cholecystitis (HP:0001082)1.64039905
174Hypercortisolism (HP:0001578)1.63760025
175Spinal cord compression (HP:0002176)1.63735106
176Recurrent cutaneous fungal infections (HP:0011370)1.63602842
177Chronic mucocutaneous candidiasis (HP:0002728)1.63602842
178Deep palmar crease (HP:0006191)1.63181346
179Premature skin wrinkling (HP:0100678)1.62726459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.45345154
2MAP4K13.36849981
3PRPF4B3.30354635
4PIM23.29964151
5MAP3K102.84908100
6BLK2.83582597
7SMG12.76177800
8MAPK152.69076960
9ICK2.58171030
10TLK12.43582339
11MAP3K112.30107358
12MAP2K32.29148421
13NME22.23532467
14EEF2K2.07947583
15TESK22.07854593
16LRRK21.95346120
17KDR1.95039909
18CDK121.93537190
19MAP2K21.90903307
20RIPK41.82775459
21GRK61.80957858
22DYRK31.68932056
23CDK191.64680913
24BTK1.60733027
25RIPK11.50174530
26ERN11.48539661
27TAOK21.48025785
28STK101.47227652
29STK161.45346306
30TAOK11.44660719
31RPS6KB21.43961185
32MUSK1.41828269
33BUB11.40262900
34MAP3K31.39629529
35MARK21.38756404
36SIK21.38070114
37KIT1.33617582
38EPHA21.27644986
39SIK31.26353102
40FGFR41.23699872
41CSK1.19460239
42TBK11.19366516
43EPHB11.18874389
44DYRK1B1.16791253
45PIM11.14829087
46MATK1.14379097
47WEE11.12112205
48MAP3K141.10386832
49TNK21.09794415
50MAP3K11.09028108
51BCKDK1.08344103
52ILK1.07694315
53JAK31.07149208
54MAPK111.07147579
55IKBKE1.07031228
56MAP3K131.06309213
57PTK61.03113228
58CSF1R1.02483455
59MAP3K61.01703440
60IRAK41.01175261
61IKBKB1.00931343
62CDC42BPA0.99094631
63CDK70.98565575
64RPS6KA20.97358736
65RPS6KA60.96696874
66ZAP700.95404696
67RPS6KL10.93551302
68RPS6KC10.93551302
69LYN0.93058716
70DAPK30.91672886
71PRKD20.91387032
72UHMK10.90680048
73VRK10.89902006
74LCK0.89321028
75FLT30.88641026
76SYK0.88145979
77FGR0.87126066
78PDPK10.86745463
79CAMKK10.82957508
80MAPK40.82268980
81CLK10.81839928
82MTOR0.81090385
83MST40.79085631
84TYK20.76549377
85TTN0.76238572
86BMX0.74924951
87PRKD30.73520648
88TRIB30.73508719
89NEK20.73406332
90MAPKAPK50.72975303
91MAPK120.72668029
92ARAF0.72137304
93MAPKAPK30.71832395
94PDGFRA0.71755612
95RPS6KA50.68807023
96HIPK20.64716664
97MAP3K80.64450890
98SIK10.64363274
99PKN20.61560258
100MST1R0.61253658
101CHUK0.60888998
102ITK0.60221411
103MAP2K60.60019751
104TEC0.58624901
105STK40.57646398
106FES0.56938515
107KSR20.55682455
108PDK10.54708261
109RPS6KA10.52713036
110MKNK20.52158446
111TRPM70.52157787
112CDK40.51894373
113JAK10.50448471
114RAF10.49555847
115TGFBR20.48639006
116PAK10.48438138
117LMTK20.47602522
118RET0.46942118
119DDR20.46899535
120PAK20.46324252
121STK390.45754260
122MAPKAPK20.45694553
123AURKA0.45667472
124STK380.45314745
125CSNK2A20.44733983
126IRAK10.44693734
127SRPK10.43778569
128IRAK30.42842814
129EPHA30.41237829
130HCK0.41040669
131MAP3K70.41033040
132TNIK0.40711640
133PAK40.40074202
134TESK10.39492202
135MAPK70.39113428
136CSNK2A10.38279322
137BRAF0.37702619
138IRAK20.37224285
139TYRO30.37080057
140TXK0.36993365
141GSK3A0.36538953
142PRKCQ0.35775568
143AURKB0.35624633
144MAP3K20.33221467
145NME10.32833287

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.75039318
2Sulfur relay system_Homo sapiens_hsa041223.90480084
3DNA replication_Homo sapiens_hsa030303.39760624
4Mismatch repair_Homo sapiens_hsa034302.44688114
5Primary immunodeficiency_Homo sapiens_hsa053402.19141407
6Folate biosynthesis_Homo sapiens_hsa007902.18716719
7Spliceosome_Homo sapiens_hsa030402.13850985
8Oxidative phosphorylation_Homo sapiens_hsa001902.05624135
9VEGF signaling pathway_Homo sapiens_hsa043702.05484614
10Base excision repair_Homo sapiens_hsa034102.01726509
11Chronic myeloid leukemia_Homo sapiens_hsa052201.96833824
12RNA polymerase_Homo sapiens_hsa030201.95786462
13Osteoclast differentiation_Homo sapiens_hsa043801.93861326
14Non-small cell lung cancer_Homo sapiens_hsa052231.92370379
15Parkinsons disease_Homo sapiens_hsa050121.89547434
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87259515
17Protein export_Homo sapiens_hsa030601.80069661
18Proteasome_Homo sapiens_hsa030501.75756711
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72932483
20Nucleotide excision repair_Homo sapiens_hsa034201.68222039
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66935530
22Homologous recombination_Homo sapiens_hsa034401.66016367
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62660154
24Pyrimidine metabolism_Homo sapiens_hsa002401.61783799
25Sulfur metabolism_Homo sapiens_hsa009201.59853607
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58636910
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.49902111
28Pancreatic cancer_Homo sapiens_hsa052121.49761226
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41261179
30Huntingtons disease_Homo sapiens_hsa050161.40971418
31TNF signaling pathway_Homo sapiens_hsa046681.38469283
32Systemic lupus erythematosus_Homo sapiens_hsa053221.38153900
33Prion diseases_Homo sapiens_hsa050201.36423391
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34331485
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32983512
36Pentose phosphate pathway_Homo sapiens_hsa000301.32305390
37Toxoplasmosis_Homo sapiens_hsa051451.32296616
38Influenza A_Homo sapiens_hsa051641.31405891
39Hepatitis B_Homo sapiens_hsa051611.31387997
40mTOR signaling pathway_Homo sapiens_hsa041501.30817748
41Alzheimers disease_Homo sapiens_hsa050101.29450905
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29043350
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.28830099
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27645573
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27377815
46Tuberculosis_Homo sapiens_hsa051521.26982227
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26016149
48Endometrial cancer_Homo sapiens_hsa052131.24480605
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21259691
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.20855049
51Hepatitis C_Homo sapiens_hsa051601.20095415
52Glutathione metabolism_Homo sapiens_hsa004801.20089732
53ErbB signaling pathway_Homo sapiens_hsa040121.19319162
54Renal cell carcinoma_Homo sapiens_hsa052111.18089135
55Prolactin signaling pathway_Homo sapiens_hsa049171.14759635
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.12794237
57Choline metabolism in cancer_Homo sapiens_hsa052311.11691135
58B cell receptor signaling pathway_Homo sapiens_hsa046621.08560810
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.07287829
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.06525633
61Glioma_Homo sapiens_hsa052141.06525251
62GnRH signaling pathway_Homo sapiens_hsa049121.06017655
63Lysosome_Homo sapiens_hsa041421.04336687
64One carbon pool by folate_Homo sapiens_hsa006701.02845270
65Fatty acid elongation_Homo sapiens_hsa000621.02720777
66Antigen processing and presentation_Homo sapiens_hsa046121.01651940
67Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00637811
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00344822
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00116046
70HTLV-I infection_Homo sapiens_hsa051660.99597711
71Inositol phosphate metabolism_Homo sapiens_hsa005620.98926419
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.97599590
73Histidine metabolism_Homo sapiens_hsa003400.97516900
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96149373
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95566276
76Endocytosis_Homo sapiens_hsa041440.93036543
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92406168
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91287293
79Fructose and mannose metabolism_Homo sapiens_hsa000510.90136354
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89596452
81Insulin signaling pathway_Homo sapiens_hsa049100.88669711
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.88214987
83Arginine and proline metabolism_Homo sapiens_hsa003300.88082835
84Staphylococcus aureus infection_Homo sapiens_hsa051500.87125297
85Chemokine signaling pathway_Homo sapiens_hsa040620.87035460
86Salmonella infection_Homo sapiens_hsa051320.86937798
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86706938
88Amoebiasis_Homo sapiens_hsa051460.86162410
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85267370
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.83470880
91Hematopoietic cell lineage_Homo sapiens_hsa046400.83329065
92Chemical carcinogenesis_Homo sapiens_hsa052040.82549336
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82373769
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.81570495
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.81419814
96Estrogen signaling pathway_Homo sapiens_hsa049150.80694300
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80602179
98Colorectal cancer_Homo sapiens_hsa052100.79931893
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79395436
100Steroid biosynthesis_Homo sapiens_hsa001000.78528076
101HIF-1 signaling pathway_Homo sapiens_hsa040660.78065421
102Allograft rejection_Homo sapiens_hsa053300.77000486
103Small cell lung cancer_Homo sapiens_hsa052220.76716947
104Insulin resistance_Homo sapiens_hsa049310.76172664
105Acute myeloid leukemia_Homo sapiens_hsa052210.75250825
106Other glycan degradation_Homo sapiens_hsa005110.74634312
107Prostate cancer_Homo sapiens_hsa052150.74551655
108Pertussis_Homo sapiens_hsa051330.73752780
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72576719
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72310028
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68590881
112Cell cycle_Homo sapiens_hsa041100.68394113
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67817464
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.67534932
115RNA degradation_Homo sapiens_hsa030180.66670434
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65436693
117Peroxisome_Homo sapiens_hsa041460.63267336
118Fanconi anemia pathway_Homo sapiens_hsa034600.63008270
119Herpes simplex infection_Homo sapiens_hsa051680.62951619
120Biosynthesis of amino acids_Homo sapiens_hsa012300.62908877
121FoxO signaling pathway_Homo sapiens_hsa040680.62854126
122Autoimmune thyroid disease_Homo sapiens_hsa053200.62177301
123Measles_Homo sapiens_hsa051620.61977640
124Graft-versus-host disease_Homo sapiens_hsa053320.61437182
125MAPK signaling pathway_Homo sapiens_hsa040100.60031740
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59978237
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59772812
128Metabolic pathways_Homo sapiens_hsa011000.59718865
129Purine metabolism_Homo sapiens_hsa002300.59642173
130Basal transcription factors_Homo sapiens_hsa030220.59266163
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58977294
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58970023
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57962231
134p53 signaling pathway_Homo sapiens_hsa041150.57684131
135RNA transport_Homo sapiens_hsa030130.57438860
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57403930
137Pyruvate metabolism_Homo sapiens_hsa006200.57118091
138Proteoglycans in cancer_Homo sapiens_hsa052050.56380654
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.55747562
140Legionellosis_Homo sapiens_hsa051340.55543249
141Vitamin B6 metabolism_Homo sapiens_hsa007500.54998934
142Thyroid cancer_Homo sapiens_hsa052160.54275601
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53771169
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53472034
145Arachidonic acid metabolism_Homo sapiens_hsa005900.53422186
146Notch signaling pathway_Homo sapiens_hsa043300.53358795
147Caffeine metabolism_Homo sapiens_hsa002320.53192200
148Bladder cancer_Homo sapiens_hsa052190.52272489
149Linoleic acid metabolism_Homo sapiens_hsa005910.51210005
150Leishmaniasis_Homo sapiens_hsa051400.47916447
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47802882
152Viral carcinogenesis_Homo sapiens_hsa052030.47489466
153Apoptosis_Homo sapiens_hsa042100.46891541
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45700038
155Epstein-Barr virus infection_Homo sapiens_hsa051690.45639598
156Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45423035
157Complement and coagulation cascades_Homo sapiens_hsa046100.44413092
158T cell receptor signaling pathway_Homo sapiens_hsa046600.44051814
159Selenocompound metabolism_Homo sapiens_hsa004500.42587027
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40022374
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38907656
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36586698
163Non-homologous end-joining_Homo sapiens_hsa034500.35670709
164Galactose metabolism_Homo sapiens_hsa000520.35303730
165Tryptophan metabolism_Homo sapiens_hsa003800.34376738
166Malaria_Homo sapiens_hsa051440.34230957
167Retinol metabolism_Homo sapiens_hsa008300.34222681
168Shigellosis_Homo sapiens_hsa051310.34213241
169Jak-STAT signaling pathway_Homo sapiens_hsa046300.33237351
170alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32566387

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